CN105588872A - Quick on-line atmospheric photo ionization mass spectrum device for effective constituent in complex substrate - Google Patents
Quick on-line atmospheric photo ionization mass spectrum device for effective constituent in complex substrate Download PDFInfo
- Publication number
- CN105588872A CN105588872A CN201610116956.7A CN201610116956A CN105588872A CN 105588872 A CN105588872 A CN 105588872A CN 201610116956 A CN201610116956 A CN 201610116956A CN 105588872 A CN105588872 A CN 105588872A
- Authority
- CN
- China
- Prior art keywords
- atmospheric pressure
- mass
- supervisor
- pressure photoionization
- solvent flashing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/64—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
Abstract
The invention relates to a quick on-line atmospheric photo ionization mass spectrum device for an effective constituent in a complex substrate. The device comprises a pre-processing device, an atmospheric photo ionization source and a mass spectrometer, wherein the pre-processing device comprises an ultrasonic atomization mechanism, a volatile solvent introducing mechanism and a heating transfer mechanism. The device can be used for realizing the sensitive, quick and reliable qualitative and quantitative analysis after a to-be-detected sample containing complex substrate (such as, soil remained on explosion site, inferior milk power, food containing illegal additives, rootstocks of medicinal plants and the like) is directly put into the ultrasonic atomization mechanism and is subjected to ultrasonic atomization extraction, and then is delivered to and ionized at the front end of the atmospheric photo ionization source after being subjected to ultrasonic atomization and heating vaporization treatment and being converged with the volatile solvent. The device has wide application prospect at the aspects of discovery and identification of natural products, environment monitoring, criminal investigation, food safety, drug monitoring, etc.
Description
Technical field
The invention belongs to analysis technical field, be specially a kind of fast online atmospheric pressure photoionization mass spectrometric apparatus for complex matrices inside active ingredient.
Background technology
Compare with existing analysis means, especially spectral technique (such as infrared, ultraviolet, fluorescence etc.), mass spectral analysis is because its high sensitivity, high specific and high-throughout advantage more and more obtain people's attention in analytical chemistry field. Current discovery and qualification at natural products, environmental monitoring, criminal investigation, the aspects such as food security and drug monitoring, mass-spectrometric technique is widely used. But such as, due to common undressed sample substrate complexity (root, stem and leaf of explosion scene soil, milk powder inferior, the food that contains illegal additive and the medicinal plant left over etc.), before by mass spectral analysis, sample all needs conventionally through pretreatment process such as extraction, enrichment, chromatographic isolation, this process time and effort consuming, analysis cost is high.
Therefore, at earlier 2000s, someone has proposed can be used for the quick mass spectrometric analysis method of complex sample surface Direct Analysis, desorption electrospray MALDI-MS (DESI) and in real time Direct Analysis mass spectrum (DART). On this basis, a series of new mass spectrometric analysis methods are suggested and their unification are called to open type atmospheric pressure mass spectrum (AMS), comprise atmospheric pressure solid analysis probe mass spectrum (ASAP), low temperature plasma MALDI-MS (LTP) and ullrasonic spraying MALDI-MS (SSI) etc. In these methods, drop, thermal current or the plasma flow that compound can produce by spraying from the surface desorption of sample out, thereby detected by spectrometer analysis. But the ion or the plasma that mainly produce by electron spray ionisation, ullrasonic spraying ionization due to above-mentioned analytical method make compound ionization, low pole and nonpolar compound ionizing efficiency are lower; Secondly, as mentioned above, above-mentioned analytical method is to go out determinand by the surface desorption of the purging such as thermal current or plasma flow sample, thereby the material of matrix inside does not still desorb or desorption efficiency is very low, just be more difficult to realize for the quantitative analysis of matrix internalization compound so; On the other hand, in the process of desorb, (for example DESI) rushes at the surface of sample sometimes to need there is very strong air-flow, thereby cannot Direct Analysis for the sample (as soil, milk powder etc.) of Particle Phase, otherwise can bring serious pollution to instrument.
Summary of the invention
In order to solve the problem of above-mentioned existence, the invention provides a kind of fast online atmospheric pressure photoionization mass spectrometric apparatus for complex matrices inside active ingredient.
A kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient comprises pretreating device, atmospheric pressure photoionization source and mass spectrograph.
Described pretreating device comprises ultrasonic atomizatio mechanism, solvent flashing retraction mechanism and adds heat transport mechanism.
Described ultrasonic atomizatio mechanism comprises ultrasonic atomizer 3, in the ultrasonic atomizatio chamber 6 of ultrasonic atomizer 3, is provided with extractant 4, and a side of ultrasonic atomizatio chamber 6 is being communicated with the first carrier gas pipe 1, the first carrier gas pipe 1 and is being provided with first flow meter 2.
Described solvent flashing retraction mechanism comprises solvent flashing storage tank 10, is provided with solvent flashing 9 in solvent flashing storage tank 10; The end that one side of solvent flashing storage tank 10 is being communicated with the second carrier gas pipe 7, the second carrier gas pipes 7 stretches in solvent flashing storage tank, and extend into below the liquid level of solvent flashing 9.
The described heat transport mechanism that adds comprises the supervisor 12 who keeps steady temperature, described supervisor's 12 entrance point is being communicated with the ultrasonic atomizatio chamber 6 of ultrasonic atomizer 3, supervisor 12 port of export correspondence the front end in mass spectrograph entrance 16 and atmospheric pressure photoionization source, and the outlet of solvent flashing storage tank 10 is being communicated with the middle part of being responsible for 12; Described supervisor's 12 temperature remains 200 ~ 500 DEG C.
Determinand 5 is located in the extractant 4 of ultrasonic atomizatio chamber 6;
Under positive ion mode, on mass spectrograph entrance 16, be applied with the voltage of-1 ~-6KV, the flow velocity of the dry gas 17 of mass spectrometric sample feeding pipe 18 outsides is at 3 ~ 10L/min, and temperature is at 100 ~ 400 DEG C.
The detailing further limiting is as follows:
Described atmospheric pressure photoionization source is VUV discharge lamp 15, and the outside of VUV discharge lamp is provided with the port of export of the 3rd carrier gas pipe 14, the three carrier gas pipes 14 facing to the bright dipping end of VUV discharge lamp, and the 3rd carrier gas pipe 14 is provided with the 3rd flowmeter 13.
Described mass spectrograph is flight time mass spectrum or level Four bar mass spectrum or ion trap mass spectrometry or Fourier transform ion cyclotron resonance mass spectroscopy or track trap mass spectrum or tandem mass spectrum.
On described supervisor 12, be arranged with heater strip 11, the internal diameter of supervisor 12 the port of export is at 1 ~ 4mm.
Described supervisor's 12 the port of export is parallel to mass spectrograph entrance 16, and the spacing of horizontal direction is 15 ~ 30mm between the two, and the spacing of vertical direction is 2 ~ 6mm, and the front end in described atmospheric pressure photoionization source is perpendicular to supervisor 12 the port of export.
Described supervisor's 12 the port of export is perpendicular to mass spectrograph entrance 16, and the spacing of horizontal direction is 5 ~ 30mm between the two, and the spacing of vertical direction is 2 ~ 10mm, and the front end in described atmospheric pressure photoionization source is vertical corresponding up and down with mass spectrograph entrance.
Described extractant 4 for first alcohol and water by volume 3:1 be mixed.
Described solvent flashing 9 for toluene and methyl phenyl ethers anisole by volume 1:1 be mixed.
Useful technique effect of the present invention embodies in the following areas:
1. apparatus of the present invention can be carried out Direct Analysis to the active ingredient of complex matrices inside, the such as jelly of soil, capsule, food, plant roots cauline leaf, animal tissue and thickness etc., the mass spectrogram of the orange peel internal component being obtained by the method from Fig. 3, the Main Flavonoids of orange peel inside and flavanone composition can be by fast detecting, as hesperetin (m/z303.08), orange peel element (m/z373.13), nobiletin (m/z403.14), Didymin (m/z595.20) and aurantiamarin (m/z611.19）。
Due to mass spectrograph entrance and supervisor's the port of export not point-blank, this device is in Direct Analysis Particle Phase, thickness phase sample, mass spectrograph can't be subject to serious pollution.
3. dry gas generally has the effect of desolventizing in mass spectrograph, in this device, can also make mass spectrometric vacuum system avoid the pollution of complex matrices.
4. this device is purging in the surperficial You Yi of VUV discharge lamp road carrier gas, this carrier gas has two effects, one can directly purge VUV discharge lamp surface and near pollutant, prevents that discharge lamp from being polluted, and ensures stability in use and the service life of discharge lamp; Its two surface at VUV discharge lamp forms one deck nitrogen protection layer, reduces the loss of photon in atmosphere, extends the propagation distance of photon in atmosphere, thereby improves photon utilization ratio and photo-ionisation efficiency.
5. this device all can effectively ionize for matrix inside polarity and nonpolar compound, without discrimination.
6. apparatus of the present invention can also be analyzed the compound direct quantitative of matrix inside, are used the linear relationship of pyrene in the soil that the method obtains by Fig. 4, and this linear coefficient correlation can reach 0.99602, visible, at 3-150ngmg-1Scope in the present invention can do quantitative analysis to the pyrene in soil.
Brief description of the drawings
Fig. 1 is when to be mass spectrograph entrance parallel with supervisor's the port of export, structural representation of the present invention.
Fig. 2 is when to be mass spectrograph entrance vertical with supervisor's the port of export, structural representation of the present invention.
Fig. 3 is under positive ion mode, using toluene as solvent flashing, and the mass spectrogram of the inner active ingredient of the orange peel of acquisition.
Fig. 4 is under positive ion mode, using toluene and methyl phenyl ethers anisole by volume 1:1 mix as solvent flashing, the linear relationship chart of pyrene in the soil of acquisition.
Sequence number in Fig. 1: the first carrier gas pipe 1, first flow meter 2, ultrasonic atomizer 3, extractant 4, determinand 5, ultrasonic atomizatio chamber 6, the second carrier gas pipe 7, the second flowmeter 8, solvent flashing 9, solvent flashing storage tank 10, heater strip 11, supervisor 12, the 3rd flowmeter 13, the 3rd carrier gas pipe 14, VUV discharge lamp 15, mass spectrograph entrance 16, dry gas 17, mass spectrograph sample feeding pipe 18.
Detailed description of the invention
Below in conjunction with accompanying drawing, by embodiment, the present invention is described further.
Embodiment 1
Referring to Fig. 1, comprise pretreating device, atmospheric pressure photoionization source and mass spectrograph for the fast online atmospheric pressure photoionization mass spectrometric apparatus of complex matrices inside active ingredient. Pretreating device comprises ultrasonic atomizatio mechanism, solvent flashing retraction mechanism and adds heat transport mechanism. Atmospheric pressure photoionization source is VUV discharge lamp 15, and the outside of VUV discharge lamp 15 is provided with the port of export of the 3rd carrier gas pipe 14, the three carrier gas pipes 14 facing to the bright dipping end of VUV discharge lamp 15, and the 3rd flowmeter 13 is installed on the 3rd carrier gas pipe 14. Mass spectrograph is time of-flight mass spectrometer.
Ultrasonic atomizatio mechanism comprises ultrasonic atomizer 3, in the ultrasonic atomizatio chamber 6 of ultrasonic atomizer 3, extractant 4 is housed, extractant 4 for first alcohol and water by volume 3:1 be mixed, a side of ultrasonic atomizatio chamber 6 is being communicated with on the first carrier gas pipe 1, the first carrier gas pipe 1 first flow meter 2 is being installed.
Solvent flashing retraction mechanism comprises solvent flashing storage tank 10, and solvent flashing 9 is housed in solvent flashing storage tank 10, and solvent flashing 9 is toluene; The end that one side of solvent flashing storage tank 10 is being communicated with the second carrier gas pipe 7, the second carrier gas pipes 7 stretches in solvent flashing storage tank, and extend into below the liquid level of solvent flashing 9.
Add heat transport mechanism and comprise the supervisor 12 who keeps steady temperature, on supervisor 12, be arranged with heater strip 11, the internal diameter of supervisor 12 the port of export is 2mm. Supervisor 12 entrance point is being communicated with the ultrasonic atomizatio chamber 6 of ultrasonic atomizer 3, supervisor 12 port of export correspondence the front end in mass spectrograph entrance 16 and atmospheric pressure photoionization source, supervisor 12 the port of export is parallel to mass spectrograph entrance 16, the spacing of horizontal direction is 22mm between the two, the spacing of vertical direction is 3mm, and the bright dipping end of VUV discharge lamp 15 is perpendicular to supervisor 12 the port of export. The outlet of solvent flashing storage tank 10 is being communicated with the middle part of being responsible for 12; Supervisor 12 temperature remains 300 DEG C.
Determinand 5 is placed in the extractant 4 of ultrasonic atomizatio chamber 6.
Operation principle of the present invention is described as follows:
Determinand 5 is before mass spectral analysis, first will be responsible for 12 heating 10min, make the temperature stabilization of being responsible for 12 inwalls at 300 DEG C, then determinand 5 is placed in to the extractant 4 of ultrasonic atomizatio chamber 6, open ultrasonic atomizer 3 and regulate its input power, through ultrasonic atomizatio extraction 30 seconds, obtain vaporific extract; After having extracted, open atmospheric pressure photoionization source and mass spectrograph, open first flow meter 2, the second flowmeter 8 and the 3rd flowmeter 13 simultaneously, the nitrogen of inputting from the 3rd carrier gas pipe 14 blows to the surface of VUV discharge lamp 15, surface and near pollutant are purged totally, form one deck nitrogen protection layer on the surface of VUV discharge lamp simultaneously; The nitrogen of inputting from the first carrier gas pipe 1 is brought the vaporific extract in ultrasonic atomizatio chamber 6 into supervisor 12, the nitrogen of inputting from the second carrier gas pipe 7 is brought the solvent flashing in solvent flashing storage tank 10 9 into supervisor 12, converge with the extract of gasification, then the front end that arrives atmospheric pressure photoionization source by being responsible for 12 the port of export is ionized, the ion producing after ionization can, under the effect of electric field and pressure differential, enter the analyzed detection of mass analyzer in vacuum system by mass spectrograph entrance 16 and mass spectrograph sample feeding pipe 18. Under positive ion mode, the voltage of be applied with on mass spectrograph entrance 16-3.5KV, the flow velocity of the dry gas 17 of mass spectrometric sample feeding pipe 18 outsides is at 5L/min, and temperature is at 325 DEG C.
Embodiment 2
Referring to Fig. 2, mass spectrograph is level Four bar mass spectrograph. Extractant 4 for first alcohol and water by volume 3:1 be mixed, solvent flashing 9 for toluene and methyl phenyl ethers anisole by volume 1:1 be mixed;
Supervisor 12 the port of export is perpendicular to mass spectrograph entrance 16, and the spacing of horizontal direction is 15mm between the two, and the spacing of vertical direction is 3mm, and the bright dipping end of VUV discharge lamp 15 is vertical corresponding up and down with mass spectrograph entrance.
Under positive ion mode, the voltage of be applied with on mass spectrograph entrance 16-3.5KV, the flow velocity of the dry gas 17 of mass spectrometric sample feeding pipe 18 outsides is at 3.5L/min, and temperature is at 300 DEG C.
Other structure and operation principle are with embodiment 1.
Claims (8)
1. for a fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient, comprise pretreating device, atmospheric pressure photoionization source and mass spectrograph, it is characterized in that:
Described pretreating device comprises ultrasonic atomizatio mechanism, solvent flashing retraction mechanism and adds heat transport mechanism;
Described ultrasonic atomizatio mechanism comprises ultrasonic atomizer (3), in the ultrasonic atomizatio chamber (6) of ultrasonic atomizer (3), be provided with extractant (4), one side of ultrasonic atomizatio chamber (6) is being communicated with the first carrier gas pipe (1), and the first carrier gas pipe (1) is provided with first flow meter (2);
Described solvent flashing retraction mechanism comprises solvent flashing storage tank (10), is provided with solvent flashing (9) in solvent flashing storage tank (10); One side of solvent flashing storage tank (10) is being communicated with the second carrier gas pipe (7), and the end of the second carrier gas pipe (7) stretches in solvent flashing storage tank, and extend into below the liquid level of solvent flashing (9);
The described heat transport mechanism that adds comprises the supervisor (12) who keeps steady temperature, described supervisor's (12) entrance point is being communicated with the ultrasonic atomizatio chamber (6) of ultrasonic atomizer (3), supervisor's (12) port of export correspondence the front end in mass spectrograph entrance (16) and atmospheric pressure photoionization source, and the outlet of solvent flashing storage tank (10) is being communicated with the middle part of supervisor (12); Described supervisor's (12) temperature remains 200 ~ 500 DEG C;
Determinand (5) is located in the extractant (4) of ultrasonic atomizatio chamber (6);
Under positive ion mode, on mass spectrograph entrance (16), be applied with the voltage of-1 ~-6KV, the flow velocity of the dry gas of mass spectrograph sample feeding pipe (18) outside is at 3 ~ 10L/min, and temperature is at 100 ~ 400 DEG C.
2. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, it is characterized in that: described atmospheric pressure photoionization source is VUV discharge lamp (15), the outside of VUV discharge lamp is provided with the 3rd carrier gas pipe (14), the port of export of the 3rd carrier gas pipe (14) is facing to the bright dipping end of VUV discharge lamp, and the 3rd carrier gas pipe (14) is provided with the 3rd flowmeter (13).
3. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, is characterized in that: described mass spectrograph is flight time mass spectrum or level Four bar mass spectrum or ion trap mass spectrometry or Fourier transform ion cyclotron resonance mass spectroscopy or track trap mass spectrum or tandem mass spectrum.
4. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, it is characterized in that: on described supervisor (12), be arranged with heater strip (11), the internal diameter of supervisor's (12) the port of export is at 1 ~ 4mm.
5. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, it is characterized in that: described supervisor's (12) the port of export is parallel to mass spectrograph entrance (16), the spacing of horizontal direction is 15 ~ 30mm between the two, the spacing of vertical direction is 2 ~ 6mm, and the front end in described atmospheric pressure photoionization source is perpendicular to supervisor's (12) the port of export.
6. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, it is characterized in that: described supervisor's (12) the port of export is perpendicular to mass spectrograph entrance (16), the spacing of horizontal direction is 5 ~ 30mm between the two, the spacing of vertical direction is 2 ~ 10mm, and the front end in described atmospheric pressure photoionization source is vertical corresponding up and down with mass spectrograph entrance.
7. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, is characterized in that: described extractant (4) for first alcohol and water by volume 3:1 be mixed.
8. a kind of fast online atmospheric pressure photoionization mass spectrometer for complex matrices active ingredient according to claim 1, is characterized in that: described solvent flashing (9) for toluene and methyl phenyl ethers anisole by volume 1:1 be mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610116956.7A CN105588872B (en) | 2016-03-02 | 2016-03-02 | A kind of quick online atmospheric pressure photoionization mass spectrometric apparatus for active ingredient in complex matrices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610116956.7A CN105588872B (en) | 2016-03-02 | 2016-03-02 | A kind of quick online atmospheric pressure photoionization mass spectrometric apparatus for active ingredient in complex matrices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105588872A true CN105588872A (en) | 2016-05-18 |
| CN105588872B CN105588872B (en) | 2018-09-07 |
Family
ID=55928614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610116956.7A Active CN105588872B (en) | 2016-03-02 | 2016-03-02 | A kind of quick online atmospheric pressure photoionization mass spectrometric apparatus for active ingredient in complex matrices |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105588872B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106324074A (en) * | 2016-10-20 | 2017-01-11 | 中国科学技术大学 | Atmospheric pressure photoionization mass spectrum device for analyzing solid fuel pyrolysis on line |
| CN107643357A (en) * | 2016-07-21 | 2018-01-30 | 中国石油化工股份有限公司 | The analysis method of steroid alkyl compound in a kind of petroleum geology sample |
| CN108593756A (en) * | 2018-07-02 | 2018-09-28 | 中国科学技术大学 | The device for fast detecting of trace steroids in a kind of water body |
| CN109564190A (en) * | 2016-08-19 | 2019-04-02 | 株式会社日立高新技术 | Ion analysis device |
| JP2019060824A (en) * | 2017-09-28 | 2019-04-18 | 公立大学法人首都大学東京 | Electrospray stabilization auxiliary solvent introduction device for improved nano lc-ms |
| CN109841467A (en) * | 2017-11-28 | 2019-06-04 | 中国科学院大连化学物理研究所 | A method of slowing down vacuum UV lamp rate of decay in mass spectrometer |
| CN110208358A (en) * | 2019-05-21 | 2019-09-06 | 暨南大学 | A kind of high-frequency vibration atomization ionization probe device and method |
| CN111257098A (en) * | 2018-11-30 | 2020-06-09 | 中国科学院大连化学物理研究所 | Qualitative detection method for species structure of catalyst heavy carbon |
| CN113189458A (en) * | 2021-04-28 | 2021-07-30 | 中国烟草总公司郑州烟草研究院 | Ultrasonic atomization corona discharge mass spectrum device for researching droplet interface reaction |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6079656A (en) * | 1983-10-07 | 1985-05-07 | Hitachi Ltd | Atmospheric-pressure ionization mass spectrometer |
| CN102192950A (en) * | 2011-03-11 | 2011-09-21 | 安徽中烟工业公司 | Device for analyzing gas phase chemical components of cigarette smoke on line |
| CN102313665A (en) * | 2010-06-30 | 2012-01-11 | 浙江工商大学 | Liquid-liquid micro extraction method for ultrasonic atomized and strengthened suspension drop type ion liquid |
| CN202120862U (en) * | 2010-07-06 | 2012-01-18 | 东华理工大学 | Normal pressure chemical extraction ionization source |
| WO2012145039A1 (en) * | 2011-04-20 | 2012-10-26 | Perkinelmer Health Sciences, Inc. | Sample introduction method and system for atomic spectrometry |
| CN203275111U (en) * | 2013-04-16 | 2013-11-06 | 上海宏锐新材料科技有限公司 | Sampling device for high-purity metal organic compounds |
| CN103762150A (en) * | 2014-01-27 | 2014-04-30 | 中国科学技术大学 | Ultrasonic atomization sample introduction volatile solvent assisting ionization low-pressure photo ionization mass spectrum device |
| US20150048255A1 (en) * | 2013-08-14 | 2015-02-19 | Waters Technologies Corporation (a Delaware corp) | Ion Source for Mass Spectrometer and Method of Producing Analyte Ion Stream |
| CN104415675A (en) * | 2013-09-09 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for dynamically preparing VOCs (volatile organic compounds) online at high precision |
| US20150155148A1 (en) * | 2013-08-02 | 2015-06-04 | Canon Kabushiki Kaisha | Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system |
| CN104707816A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | On-line self-cleaning method for vacuum ultraviolet lamp |
| BR102013016329A2 (en) * | 2013-06-25 | 2015-08-18 | Associação Pró Ensino Em Santa Cruz Do Sul Apesc | Multifunctional system and process for vaporization and sample introduction in analytical instruments |
| CN205404478U (en) * | 2016-03-02 | 2016-07-27 | 中国科学技术大学 | A quick online atmospheric pressure photo ionization mass spectrum device for active ingredient among complicated matrix |
-
2016
- 2016-03-02 CN CN201610116956.7A patent/CN105588872B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6079656A (en) * | 1983-10-07 | 1985-05-07 | Hitachi Ltd | Atmospheric-pressure ionization mass spectrometer |
| CN102313665A (en) * | 2010-06-30 | 2012-01-11 | 浙江工商大学 | Liquid-liquid micro extraction method for ultrasonic atomized and strengthened suspension drop type ion liquid |
| CN202120862U (en) * | 2010-07-06 | 2012-01-18 | 东华理工大学 | Normal pressure chemical extraction ionization source |
| CN102192950A (en) * | 2011-03-11 | 2011-09-21 | 安徽中烟工业公司 | Device for analyzing gas phase chemical components of cigarette smoke on line |
| WO2012145039A1 (en) * | 2011-04-20 | 2012-10-26 | Perkinelmer Health Sciences, Inc. | Sample introduction method and system for atomic spectrometry |
| CN203275111U (en) * | 2013-04-16 | 2013-11-06 | 上海宏锐新材料科技有限公司 | Sampling device for high-purity metal organic compounds |
| BR102013016329A2 (en) * | 2013-06-25 | 2015-08-18 | Associação Pró Ensino Em Santa Cruz Do Sul Apesc | Multifunctional system and process for vaporization and sample introduction in analytical instruments |
| US20150155148A1 (en) * | 2013-08-02 | 2015-06-04 | Canon Kabushiki Kaisha | Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system |
| US20150048255A1 (en) * | 2013-08-14 | 2015-02-19 | Waters Technologies Corporation (a Delaware corp) | Ion Source for Mass Spectrometer and Method of Producing Analyte Ion Stream |
| CN104415675A (en) * | 2013-09-09 | 2015-03-18 | 中国科学院大连化学物理研究所 | Method for dynamically preparing VOCs (volatile organic compounds) online at high precision |
| CN104707816A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | On-line self-cleaning method for vacuum ultraviolet lamp |
| CN103762150A (en) * | 2014-01-27 | 2014-04-30 | 中国科学技术大学 | Ultrasonic atomization sample introduction volatile solvent assisting ionization low-pressure photo ionization mass spectrum device |
| CN205404478U (en) * | 2016-03-02 | 2016-07-27 | 中国科学技术大学 | A quick online atmospheric pressure photo ionization mass spectrum device for active ingredient among complicated matrix |
Non-Patent Citations (2)
| Title |
|---|
| IVANO MARCHI ET AL.: "Atmospheric pressure photoionization for coupling liquid-chromatography to mass spectrometry：A review", 《TALANTA》 * |
| 张晓琳等: "水体中挥发性有机物超声雾化提取法的在线监测", 《环境化学》 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107643357A (en) * | 2016-07-21 | 2018-01-30 | 中国石油化工股份有限公司 | The analysis method of steroid alkyl compound in a kind of petroleum geology sample |
| CN109564190A (en) * | 2016-08-19 | 2019-04-02 | 株式会社日立高新技术 | Ion analysis device |
| CN109564190B (en) * | 2016-08-19 | 2021-02-26 | 株式会社日立高新技术 | Ion analysis apparatus |
| CN106324074A (en) * | 2016-10-20 | 2017-01-11 | 中国科学技术大学 | Atmospheric pressure photoionization mass spectrum device for analyzing solid fuel pyrolysis on line |
| JP2019060824A (en) * | 2017-09-28 | 2019-04-18 | 公立大学法人首都大学東京 | Electrospray stabilization auxiliary solvent introduction device for improved nano lc-ms |
| CN109841467A (en) * | 2017-11-28 | 2019-06-04 | 中国科学院大连化学物理研究所 | A method of slowing down vacuum UV lamp rate of decay in mass spectrometer |
| CN108593756A (en) * | 2018-07-02 | 2018-09-28 | 中国科学技术大学 | The device for fast detecting of trace steroids in a kind of water body |
| CN108593756B (en) * | 2018-07-02 | 2023-10-20 | 中国科学技术大学 | Quick detection device of trace steroid in water |
| CN111257098A (en) * | 2018-11-30 | 2020-06-09 | 中国科学院大连化学物理研究所 | Qualitative detection method for species structure of catalyst heavy carbon |
| CN110208358A (en) * | 2019-05-21 | 2019-09-06 | 暨南大学 | A kind of high-frequency vibration atomization ionization probe device and method |
| CN113189458A (en) * | 2021-04-28 | 2021-07-30 | 中国烟草总公司郑州烟草研究院 | Ultrasonic atomization corona discharge mass spectrum device for researching droplet interface reaction |
| CN113189458B (en) * | 2021-04-28 | 2024-04-30 | 中国烟草总公司郑州烟草研究院 | Ultrasonic atomization corona discharge mass spectrum device for researching liquid drop interface reaction |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105588872B (en) | 2018-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105588872B (en) | A kind of quick online atmospheric pressure photoionization mass spectrometric apparatus for active ingredient in complex matrices | |
| CN101770924B (en) | Desorbing ionization device | |
| CN101201335B (en) | Surface desorption atmospheric chemical ionization source of mass spectrometer | |
| Alfarra et al. | The effect of photochemical ageing and initial precursor concentration on the composition and hygroscopic properties of β-caryophyllene secondary organic aerosol | |
| US8723111B2 (en) | Apparatus for chemical sampling and method of assembling the same | |
| CN105470095B (en) | A kind of thermal shock gasification electron spray ionisation source and mass spectrometry system | |
| CN205122534U (en) | Ionizationoun device | |
| CN103762150B (en) | The solvent flashing auxiliary electrical of ultrasonic atomizatio sample introduction is from low-voltage optical from mass spectrometric apparatus | |
| US20120006983A1 (en) | Method of surface ionization with solvent spray and excited-state neutrals | |
| US11187629B2 (en) | Sample probe inlet flow system | |
| CN106841367A (en) | A kind of Ion transfer spectrum detection method of time resolution Dynamic Thermal parsing | |
| US8829467B2 (en) | Analytical apparatus | |
| CN101004393A (en) | Ionization method for analyzing sample, and dedicated ionization source | |
| CN108195923A (en) | The method and mass spectrometer arrangement detected for volatile organic compounds in sample | |
| CN109900773A (en) | A method of composition of air in accurate quickly analysis submarine | |
| CN205404478U (en) | A quick online atmospheric pressure photo ionization mass spectrum device for active ingredient among complicated matrix | |
| Mahjoub et al. | Characterization of aromaticity in analogues of titan's atmospheric aerosols with two-step laser desorption ionization mass spectrometry | |
| CN201185172Y (en) | Surface desorption atmospheric chemical ionization source | |
| Hartonen et al. | Current instrumentation for aerosol mass spectrometry | |
| CN104237371B (en) | Simple device for realizing real-time direct injection analysis of mass spectrometer and application of simple device | |
| Aggarwal | Recent developments in aerosol measurement techniques and the metrological issues | |
| JP3808482B2 (en) | Ion source, mass spectrometry method and mass spectrometer | |
| US8835838B2 (en) | Method and apparatus for analysis and ion source | |
| CN102539515A (en) | High-sensitivity detection method of normal temperature normal pressure surface assisted laser desorption mass spectrometry | |
| CN206208830U (en) | A kind of atmospheric pressure photoionization mass spectrometric apparatus for on-line analysis solid fuel pyrolysis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |