CN105582280A - Traditional Chinese medicine preparation for treating angina pectoris of coronary heart disease - Google Patents

Traditional Chinese medicine preparation for treating angina pectoris of coronary heart disease Download PDF

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CN105582280A
CN105582280A CN201610040202.8A CN201610040202A CN105582280A CN 105582280 A CN105582280 A CN 105582280A CN 201610040202 A CN201610040202 A CN 201610040202A CN 105582280 A CN105582280 A CN 105582280A
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李宪秋
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating angina pectoris of the coronary heart disease. A medicine for oral use comprises fructus trichosanthis, pinellia tubers, immature bitter orange, cassia twigs, platycodon roots, danshen roots, prepared common monkshood daughter roots, dried rehmannia roots, unibract fritillary bulb, peach kernels, safflower, szechuan lovage rhizomes, pearl powder, pseudo-ginseng powder and sea-ear shell; an externally-applied medicine comprises alum, rhubarb, frankincense, myrrh, rhizoma corydalis, largetrifoliolious bugbane rhizomes, borneol, musk and turmeric root-tuber. The traditional Chinese medicine is excellently compatible and adopts a reasonable formula; the medicine for oral use and the externally-applied medicine are jointly used and perform the efficacy of warming yang, benefiting qi and promoting blood circulation to remove blood stasis; blood activating and qi replenishment and qi circulation promotion are matched, stasis removal and blood nourishment and production are realized simultaneously, ascending and descending are considered, the heart-qi is sufficient through qi benefiting and blood activation, force for pushing blood to circulate is increased, the blood circulates smoothly, qi and blood are harmonious, the blood supply function of the coronary artery is balanced on a new basis, cardiac microcirculation is improved, myocardial ischemia is relieved, and accordingly, angina pectoris is relieved or even eliminated.

Description

A kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris.
Background technology
Coronary heart disease is one of important diseases threatening now healthy elder, and middle-aged and old lives has been causedVery large impact, therefore effectively prevents and treatment coronary heart disease, reduces its incidence of disease and has been subject to more and more doctorsTreatment worker's concern.
Along with the development in epoch, modern medicine thinks that this disease is due to coronary insufficiency, causes cardiac muscleSharply or the temporary transient caused clinical syndrome of hypoxic-ischemic, Western medicine is demonstrating more aspect treatment coronary heart diseaseCarry out more important effect, but most Western medicine can cause lesions of liver and kidney to patient, use for a long time not only side effectGreatly, also can produce drug resistance. And the traditional Chinese medical science has had deep understanding for a long time to coronary heart disease, and long-pending aspect treatmentTired out rich experience, and do not found any side effect, therefore traditional Chinese medicine should become medical worker and controlsTreat anginal first-selection.
Summary of the invention
The invention solves the defect of existence aspect treatment coronary disease and angina pectoris at present, provide one to take effectHurry up, short treating period, have no side effect, Chinese drugs agentia that cure rate is higher, adopt the mode of Orally taken and externally, can inRule together outward, treat both principal and secondary aspect of disease, greatly improved the rehabilitation rate of patient with angina pectoris.
The technical solution adopted in the present invention is:
A Chinese medicine preparation for the treatment of coronary disease and angina pectoris, is characterized in that: described Chinese medicine preparation comprises for oral administrationMedicine and medicine for external application, wherein:
Medicine for oral administration comprises: 10-20 gram of Chinese juniper beach wormwood, tuber of pinellia 5-15 gram, dried immature fruit of citron orange 10-20 gram, cassia twig 10-20 gram,Balloonflower root 10-20 gram, red sage root 10-20 gram, monkshood 10-20 gram, dried rhizome of rehmannia 10-20 gram, tendril-leaved fritillary bulb 10-20 gram,Peach kernel 10-20 gram, safflower 5-8 gram, Ligusticum wallichii 5-8 gram, pearl powder 3-5 gram, Radix Notoginseng powder 5-8 gram, stoneCassia tora 10-15 gram;
Medicine for external application comprises: alumen 5-8 gram, rheum officinale 5-8 gram, frankincense 5-8 gram, myrrh 5-8 gram, corydalis tuber5-8 gram, rattletop 5-8 gram, borneol 5-8 gram, Moschus 5-8 gram, root tuber of aromatic turmeric 5-8 gram.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 10 grams of Chinese juniper beach wormwoods, 5 grams of the tuber of pinellia, 10 grams of the dried immature fruit of citron oranges, 10 grams of cassia twig, 10 grams of balloonflower roots,10 grams of the reds sage root, 10 grams of monkshoods, 10 grams, the dried rhizome of rehmannia, 10 grams of tendril-leaved fritillary bulb, 10 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii5 grams, 3 grams of pearl powders, 5 grams of Radix Notoginseng powder, 10 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 5 grams of rheum officinales, 5 grams of frankincenses, 5 grams of myrrhs, 5 grams of corydalis tubers, liter5 grams of fiber crops, 5 grams of borneols, 5 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 12 grams of Chinese juniper beach wormwoods, 7 grams of the tuber of pinellia, 12 grams of the dried immature fruit of citron oranges, 12 grams of cassia twig, 12 grams of balloonflower roots,12 grams of the reds sage root, 12 grams of monkshoods, 12 grams, the dried rhizome of rehmannia, 12 grams of tendril-leaved fritillary bulb, 12 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii6 grams, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 11 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 6 grams of rheum officinales, 5 grams of frankincenses, 6 grams of myrrhs, 5 grams of corydalis tubers, liter6 grams of fiber crops, 5 grams of borneols, 6 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 14 grams of Chinese juniper beach wormwoods, 9 grams of the tuber of pinellia, 14 grams of the dried immature fruit of citron oranges, 14 grams of cassia twig, 14 grams of balloonflower roots,14 grams of the reds sage root, 14 grams of monkshoods, 14 grams, the dried rhizome of rehmannia, 14 grams of tendril-leaved fritillary bulb, 14 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii6 grams, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 12 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 6 grams of rheum officinales, 6 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter6 grams of fiber crops, 6 grams of borneols, 6 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 16 grams of Chinese juniper beach wormwoods, 11 grams of the tuber of pinellia, 16 grams of the dried immature fruit of citron oranges, 16 grams of cassia twig, 16 grams of balloonflower roots,16 grams of the reds sage root, 16 grams of monkshoods, 16 grams, the dried rhizome of rehmannia, 16 grams of tendril-leaved fritillary bulb, 16 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii7 grams, 4 grams of pearl powders, 6 grams of Radix Notoginseng powder, 13 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter7 grams of fiber crops, 6 grams of borneols, 7 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 18 grams of Chinese juniper beach wormwoods, 13 grams of the tuber of pinellia, 18 grams of the dried immature fruit of citron oranges, 18 grams of cassia twig, 18 grams of balloonflower roots,18 grams of the reds sage root, 18 grams of monkshoods, 18 grams, the dried rhizome of rehmannia, 18 grams of tendril-leaved fritillary bulb, 18 grams, peach kernel, 7 grams, safflower, Ligusticum wallichii7 grams, 4 grams of pearl powders, 7 grams of Radix Notoginseng powder, 14 grams of the shells of seaear;
Medicine for external application comprises: 7 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 7 grams of myrrhs, 7 grams of corydalis tubers, liter7 grams of fiber crops, 7 grams of borneols, 7 grams, Moschus, 7 grams of root tubers of aromatic turmeric.
As a kind of prioritization scheme, described Chinese medicine preparation comprises medicine for oral administration and medicine for external application:
Medicine for oral administration comprises: 20 grams of Chinese juniper beach wormwoods, 15 grams of the tuber of pinellia, 20 grams of the dried immature fruit of citron oranges, 20 grams of cassia twig, 20 grams of balloonflower roots,20 grams of the reds sage root, 20 grams of monkshoods, 20 grams, the dried rhizome of rehmannia, 20 grams of tendril-leaved fritillary bulb, 20 grams, peach kernel, 8 grams, safflower, Ligusticum wallichii8 grams, 5 grams of pearl powders, 8 grams of Radix Notoginseng powder, 15 grams of the shells of seaear;
Medicine for external application comprises: 8 grams of alumens, 8 grams of rheum officinales, 8 grams of frankincenses, 8 grams of myrrhs, 8 grams of corydalis tubers, liter8 grams of fiber crops, 8 grams of borneols, 8 grams, Moschus, 8 grams of root tubers of aromatic turmeric.
The instructions of taking of said medicine is: by Chinese juniper beach wormwood, the tuber of pinellia, the dried immature fruit of citron orange, cassia twig, balloonflower root, the red sage root, monkshood,The dried rhizome of rehmannia, tendril-leaved fritillary bulb, peach kernel, safflower, Ligusticum wallichii, pearl powder, Radix Notoginseng powder, the shell of seaear, join according to constant weightAfter mixing than (with disease plus-minus), according to the method decocting system of the fried Chinese medicine of tradition, every day, potion, divided 2 timesWarmly taking, 7 days is a course for the treatment of. Simultaneously by alumen, rheum officinale, frankincense, myrrh, corydalis tuber, rattletop, borneol, musk deerFragrant, root tuber of aromatic turmeric is dried and is crushed into powder according to constant weight proportioning (with disease plus-minus), then is in harmonious proportion even with vaselineAfter be applied in affected part, topical application of drug every day 2 times.
The raw material Chinese medicine of said medicine:
Chinese juniper beach wormwood, bitter, cold in nature; Return lung, stomach two warps. Have clearing away heat and eliminating phlegm, relieving chest stiffness to dissipate mass, moisturizes laxationEffect, can descend gas to wash dirty, the strongly fragrant appetizing that especially disappears, the sthenia cold fullness of chest that can cure the wound, eliminates the phlegm, quench one's thirst and promote the production of body fluid again, underBreast.
The tuber of pinellia, taste is pungent, warm in nature; Return spleen, stomach, lung channel. Have eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the ruffian that disappears is looseEffect of knot.
The dried immature fruit of citron orange, bitter, pungent, cold nature; Return spleen, stomach, large intestine channel. There is relieving stagnant Qi and disappear long-pendingly, reduce phlegm except ruffianEffect.
Cassia twig, taste is pungent, sweet, warm in nature; The thoughts of returning home, spleen, urinary bladder channel. There is expelling pathogenic factors from muscles by diaphoresis, warming meridian to activate yang,The effect of dispelling rheumatism.
Balloonflower root, bitter, pungent, slightly warm in nature; Return lung channel. There is expelling phlegm and arresting coughing, effect of a surname's lung apocenosis.
The red sage root, bitter, cold nature; The thoughts of returning home, pericardium, Liver Channel. Have promoting blood circulation, the cool blood carbuncle that disappears, supportsEffect of blood and tranquilizing mind.
Monkshood, taste is pungent, sweet, extremely hot in nature; The thoughts of returning home, kidney, the spleen channel. There is recuperating depleted yang, mend fire supporing yang,Effect of eliminating cold to stop pain.
The dried rhizome of rehmannia, taste is sweet, bitter, cold in nature; The thoughts of returning home, liver, kidney channel. There is clearing heat and cooling blood, the merit of nourishing Yin and promoting production of body fluidEffect.
Tendril-leaved fritillary bulb, taste is sweet, flat, cool in nature; Return lung channel, stomach warp. Have and moisten the lung and relieve the cough, resolving sputum and relieving asthma, heat-clearingClears phlegm.
Peach kernel, taste is sweet, bitter, and property is flat; Return lung, liver, large intestine channel. There is promoting blood circulation, moisturize laxation itEffect.
Safflower, taste is pungent, warm in nature; The thoughts of returning home, Liver Channel. There is activating blood to promote menstruation, effect of blood stasis removing analgesic.
Ligusticum wallichii, taste is pungent, warm in nature; Return liver, courage, pericardium channel. There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.
Pearl powder, taste is sweet, salty, cold in nature; The thoughts of returning home, Liver Channel. There is the arresting convulsion of calming the nerves, the improving eyesight screen that disappears, removing toxic substancesEffect of myogenic.
Radix Notoginseng powder, sweet, the micro-hardship of taste, temperature; The thoughts of returning home, liver, the spleen channel. There is removing blood stasis and hemostasis, swelling and pain relieving itEffect.
The shell of seaear, bitter, sweet, salty, cold nature; Return liver, kidney, large intestine channel. Have and relax bowel, fallEffect of fat improving eyesight, the key medicine of Wei Lianggan town liver.
Alumen, puckery, cold in nature; Return lung, Liver Channel. There is dissolving phlegm, eliminating dampness, antidiarrheal, hemostasis, removing toxic substances,The effects such as desinsection.
Rheum officinale, bitter, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel. There is heat and toxic materials clearing away, heat-clearingPurging intense heat, removing pattogenic heat from the blood and toxic material from the body, effect of promoting blood circulation.
Frankincense, taste is pungent, bitter, warm in nature; The thoughts of returning home, liver, the spleen channel. There is promoting blood circulation and stopping pain, the merit of detumescence and promoting granulationEffect.
Myrrh, bitter, pungent, property is flat; The thoughts of returning home, liver,spleen,kidney warp. There is promoting blood circulation, detumescence ding-tongEffect.
Corydalis tuber, taste is pungent, bitter, warm in nature; Return liver, the spleen channel. There is regulating qi-flowing for relieving pain, effect of promoting blood circulation to remove blood stasis.
Rattletop, taste is sweet, pungent, cold nature; Return spleen, stomach, lung, large intestine channel. There is the promoting eruption of delivering, heat-clearingRemoving toxic substances, effect of elevate a turnable ladder yang-energy.
Borneol, taste is pungent, bitter, cold nature; The thoughts of returning home, spleen, lung channel. There is the inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain itEffect.
Moschus, taste is pungent, warm in nature. The thoughts of returning home, the spleen channel. There is the inducing resuscitation of having one's ideas straightened out, activating blood to promote menstruation, swelling and pain relieving itEffect.
Root tuber of aromatic turmeric, taste is pungent, bitter, cold in nature; The thoughts of returning home, liver, gallbladder channel. There is promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clearThe cool blood of heat, waking up the patient from unconsciousness by clearing away heart fire, effect of dampness removing removing jaundice. Root tuber of aromatic turmeric is the gas medicine of blood system, both regulated the flow of vital energy, and stagnation resolvation again,Dialectical is the conventional this product of qi depression to blood stasis person.
Vaseline is a kind of mineral wax, and it can not be absorbed by the skin, and can form diaphragm one in skin surface,The difficult evaporation of moisture of skin is scattered and disappeared, and therefore it is extremely water insoluble, can be attached to for a long time on skin,There is good moistening effect. Vaseline of the present invention, as matrix, mainly utilizes its mediation medicinal powder external application to use.
Coronary disease and angina pectoris is clinical common with ictal suffocating pain over the chest or acupuncture sample, squeezing sample pain, with gasShort, weak is feature, belongs to motherland's medical science " obstruction of qi in the chest " category. Its pathological change belongs to asthenia in origin and asthenia in superficiality more. This voidCommon with the deficiency of yang, the deficiency of vital energy, mark is real turbid as main taking hemostasis phlegm. Inward invasion of pathogenic cold, deficiency of heart-QI, phlegm is turbid illegally occupies,The resistance of mechanism of qi numbness, the blood stasis of blood is stagnant, and heart arteries and veins is obstructed is this interpretation of the cause, onset and process of an illness key. Therefore, treatment should be for this void, whenBy reinforcing method; Mark is real, when by logical method, leads to two methods of benefit for controlling the big method of the obstruction of qi in the chest.
In the present invention, Chinese juniper beach wormwood, the tuber of pinellia, tendril-leaved fritillary bulb, the dried immature fruit of citron orange, balloonflower root energy clearing away heat and eliminating phlegm, relieving chest stiffness to dissipate mass, eliminate the phlegmCough-relieving, plays the effect of regulating the flow of vital energy, slitting phlegm, relievining asthma; The red sage root, pearl powder, dried rhizome of rehmannia nourishing Yin and promoting production of body fluid, peace nourishes bloodGod, plays the effect of qi and activate blood circulation; Peach kernel, safflower, Ligusticum wallichii, Radix Notoginseng powder, frankincense, myrrh, corydalis tuber,Moschus, root tuber of aromatic turmeric all can promoting blood circulations, swelling and pain relieving, promoting qi circulation and removing obstruction in the collateral, be significantly increased coronary flow,Improve the effect of myocardial contractive power; Cassia twig, monkshood energy warming meridian to activate yang and priming is up, Wen Yang in reinforcement sideThe effect of the stasis of blood of dispelling promoting qi circulation and relieving pain; Alumen, rheum officinale, rattletop, borneol can clearing heat and detoxicating, the inducing resuscitation of having one's ideas straightened out, and dispel bodyThe damp and hot evil poison of interior diseases caused by external factors; The shell of seaear has and relaxes bowel, effect of lipopenicillinase improving eyesight, the key medicine of Wei Lianggan town liver.Full side's compatibility is superior, and reasonable recipe for oral administration is ruled together with external application, plays altogether warming yang and benefiting qi, merit promoting blood circulation and removing blood stasis,Invigorate blood circulation and tonifying Qi promoting the circulation of qi phase 5, the stasis of blood of dispelling and blood-nourishing blood-generating are with executing, and lifting takes into account, and by qi and activate blood circulation, makes the heartGas abundance, the power that promotes blood operation strengthens, blood circulation smoothness, qi and blood and tune, coronary artery blood supply meritCan on new basis, restore balance, microcirculation of the heart is improved, and myocardial ischemia-anoxemia is corrected, fromAnd angina and even elimination.
For further investigating the clinical efficacy of medicine of the present invention, we have selected 100 routine outpatient service and inpatients,All with uncomfortable in chest, feel suffocated, the general symptom such as palpitaition. Man's 63 examples, female's 37 examples; 37～68 years old age, flatEqual 61 years old; The course of disease 4 months～15 years; Western medicine diagnose is unstable angina pectoris 52 examples, stable type heart strandPain 48 examples. All patients are divided into treatment group and control group at random, every group of 50 examples, two groups of patients sex,The aspect such as age, illness, learns relatively there was no significant difference (P > 0.05) by statistics, has comparativity.
Clinical symptoms: (1) obstruction of qi in the chest diagnostic criteria: compressing suffocates, the heavy vexed swollen property pain of chest; The lighter slightlySense is felt suffocated, uncomfortable in chest and unsmooth breath; Electrocardioscopy coronary insufficiency; (2) heart arteries and veins stasis blocking diagnosisStandard: stabbing pain over the chest or angina, invariant position, evening, pain increased the weight of, or sense palpitaition, and tongue nature is dark violet, arteries and veinsResemble heavy string.
Methods for the treatment of:
Treatment group: get 14 grams of Chinese scholartree Chinese juniper beach wormwoods, 9 grams of the tuber of pinellia, 14 grams of the dried immature fruit of citron oranges, 14 grams of cassia twig, 14 grams of balloonflower roots,14 grams of the reds sage root, 14 grams of monkshoods, 14 grams, the dried rhizome of rehmannia, 14 grams of tendril-leaved fritillary bulb, 14 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii6 grams, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 12 grams of the shells of seaear, take after decocting, every day potion, points 2Inferior warmly taking. Simultaneously by 6 grams of alumens, 6 grams of rheum officinales, 6 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, rattletop 6Gram, 6 grams of borneols, 6 grams, Moschus, 6 grams of root tubers of aromatic turmeric, after drying and being crushed into powder, be in harmonious proportion all with 24 grams, vaselineEven outer spread on injury, topical application of drug every day 2 times. 7 days courses for the treatment of.
Control group: adopt simple medicine conventional therapy: each 10 balls of oral administered compound Danshen Root dropping ball, 3 times on the oneSublingual administration or warm water take. If angina pectoris attacks can be processed for interim containing taking nitroglycerine tablets.
Criterion of therapeutical effect:
1. general criterion of therapeutical effect:
Effective: angina pectoris, uncomfortable in chest, the symptom such as feel suffocated all disappear, and can carry out normal live and work;
Take a turn for the better: angina pectoris attacks number of times reduces, pain relief, chest distress symptom obviously alleviates;
Invalid: angina pectoris is not improved, chest distress is still serious, can not reply daily life and work.
Wherein effective and improvement is regarded as effectively.
2. ECG curative effect evaluation criteria:
Effective: electrocardiogram recovers normal, and arrhythmia cordis disappears, it is normal that ST-T recovers;
Take a turn for the better: after treatment, more than ECG ST section rise 0.05mV, but be normal, in the inversion of mainly leadingT ripple shoals (reaching more than 50%), or T ripple is transferred to uprightly by smooth;
Invalid: before and after treatment, electrocardiogram does not have significant change.
Efficacy result:
1. Clinical efficacy comparison:
After treatment, the attack times of angina pectoris, pain degree have improvement in various degree, and treatment group is aobviousImitate 21 examples, 27 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 42.0%, efficiently reaches 96.0%; Control group is aobviousImitate 9 examples, 25 examples that take a turn for the better, invalid 16 examples, obvious effective rate is 18.0%, efficient is 68.0%; Treatment group is controlledMore rate and the efficient control group that is all obviously better than, two groups of results are compared P < 0.01, and difference has statistical significance.Detailed results is in table 1.
Table 1: the general curative effect comparision result table after two groups of case treatments
Group Number of cases Effective n (%) Improvement n (%) Invalid n (%) Total effective rate (%)
Treatment group 50 21(42.0) 27(54.0) 2(4.0) 96.0
Control group 50 9(18.0) 25(50.0) 16(32.0) 68.0
2. ECG curative effect comparison:
After treatment, the performance of electrocardiogram myocardial ischemia has improvement in various degree, wherein effective 17 examples for the treatment of group,20 examples that take a turn for the better, invalid 3 examples, efficient 94.0%; Effective 10 examples of control group, 26 examples that take a turn for the better, invalid 14Example, efficient is 72.0%; Treatment group cure rate and the efficient control group that is all obviously better than, two groups of results are comparedP < 0.01, difference has statistical significance. Detailed results is in table 2.
Table 2: the ECG curative effect results of comparison table after two groups of case treatments
Group Number of cases Effective n (%) Improvement n (%) Invalid n (%) Total effective rate (%)
Treatment group 50 17(34.0) 20(40.0) 3(6.0) 94.0
Control group 50 10(36.0) 26(52.0) 14(28.0) 72.0
3. side effect comparison
Observe patient clinical side effect, treatment group only has 8 examples to occur dry at the treatment initial stage, swallow the discomforts such as dryBut after continuing medication and suitably increasing amount of drinking water, can die away, not affect treatment. Liver, kidney and hemopoietic systemBe showed no bad reaction. Control group has no obvious adverse reaction.
Result shows, the Chinese medicine of the present invention coronary disease and angina pectoris interpretation of the cause, onset and process of an illness that hits adopts the methods for the treatment of of Orally taken and externally,Can inside and outside rule together, effectively improve and alleviate the symptoms such as uncomfortable in chest, pained, promote the recovery of ischemic ST-T, alsoCan improve human immunity and resistivity, improve cardiac function, evident in efficacy and have no side effect, clinicPromotion and application.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 10 grams of Chinese juniper beach wormwoods, 5 grams of the tuber of pinellia, 10 grams of the dried immature fruit of citron oranges, 10 grams of cassia twig, 10 grams of balloonflower roots, pelletJoin 10 grams, 10 grams of monkshoods, 10 grams, the dried rhizome of rehmannia, 10 grams of tendril-leaved fritillary bulb, 10 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii 5Gram, 3 grams of pearl powders, 5 grams of Radix Notoginseng powder, 10 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 5 grams of rheum officinales, 5 grams of frankincenses, 5 grams of myrrhs, 5 grams of corydalis tubers, liter5 grams of fiber crops, 5 grams of borneols, 5 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 12 grams of Chinese juniper beach wormwoods, 7 grams of the tuber of pinellia, 12 grams of the dried immature fruit of citron oranges, 12 grams of cassia twig, 12 grams of balloonflower roots, pelletJoin 12 grams, 12 grams of monkshoods, 12 grams, the dried rhizome of rehmannia, 12 grams of tendril-leaved fritillary bulb, 12 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii 6Gram, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 11 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 6 grams of rheum officinales, 5 grams of frankincenses, 6 grams of myrrhs, 5 grams of corydalis tubers, liter6 grams of fiber crops, 5 grams of borneols, 6 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 14 grams of Chinese juniper beach wormwoods, 9 grams of the tuber of pinellia, 14 grams of the dried immature fruit of citron oranges, 14 grams of cassia twig, 14 grams of balloonflower roots, pelletJoin 14 grams, 14 grams of monkshoods, 14 grams, the dried rhizome of rehmannia, 14 grams of tendril-leaved fritillary bulb, 14 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii 6Gram, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 12 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 6 grams of rheum officinales, 6 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter6 grams of fiber crops, 6 grams of borneols, 6 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
Embodiment 4: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 16 grams of Chinese juniper beach wormwoods, 11 grams of the tuber of pinellia, 16 grams of the dried immature fruit of citron oranges, 16 grams of cassia twig, 16 grams of balloonflower roots, pelletJoin 16 grams, 16 grams of monkshoods, 16 grams, the dried rhizome of rehmannia, 16 grams of tendril-leaved fritillary bulb, 16 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii 7Gram, 4 grams of pearl powders, 6 grams of Radix Notoginseng powder, 13 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter7 grams of fiber crops, 6 grams of borneols, 7 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
Embodiment 5: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 18 grams of Chinese juniper beach wormwoods, 13 grams of the tuber of pinellia, 18 grams of the dried immature fruit of citron oranges, 18 grams of cassia twig, 18 grams of balloonflower roots, pelletJoin 18 grams, 18 grams of monkshoods, 18 grams, the dried rhizome of rehmannia, 18 grams of tendril-leaved fritillary bulb, 18 grams, peach kernel, 7 grams, safflower, Ligusticum wallichii 7Gram, 4 grams of pearl powders, 7 grams of Radix Notoginseng powder, 14 grams of the shells of seaear;
Medicine for external application comprises: 7 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 7 grams of myrrhs, 7 grams of corydalis tubers, liter7 grams of fiber crops, 7 grams of borneols, 7 grams, Moschus, 7 grams of root tubers of aromatic turmeric.
Embodiment 6: a kind of Chinese medicine preparation for the treatment of coronary disease and angina pectoris, choose medicine for oral administration and medicine for external application, wherein:Medicine for oral administration comprises: 20 grams of Chinese juniper beach wormwoods, 15 grams of the tuber of pinellia, 20 grams of the dried immature fruit of citron oranges, 20 grams of cassia twig, 20 grams of balloonflower roots, pelletJoin 20 grams, 20 grams of monkshoods, 20 grams, the dried rhizome of rehmannia, 20 grams of tendril-leaved fritillary bulb, 20 grams, peach kernel, 8 grams, safflower, Ligusticum wallichii 8Gram, 5 grams of pearl powders, 8 grams of Radix Notoginseng powder, 15 grams of the shells of seaear;
Medicine for external application comprises: 8 grams of alumens, 8 grams of rheum officinales, 8 grams of frankincenses, 8 grams of myrrhs, 8 grams of corydalis tubers, liter8 grams of fiber crops, 8 grams of borneols, 8 grams, Moschus, 8 grams of root tubers of aromatic turmeric.
Below by concrete case, curative effect of medication of the present invention is further verified:
Case 1
Fourth, man, 55 years old. Patient has felt uncomfortable in chest breathing hard the year before always, and pareordia sense of depression is livedMoving postemphasis, sleep is unstable, and palpitation and being susceptible to fright is dizzy once in a while, and two lower limb are sometimes swollen, and two is just normal. OnceGo to see a doctor, the inspection such as have an electro-cardiogram, is diagnosed as coronary heart diseases and angina pectoris. So take under friend recommendationWith we's treatment, observation patient complexion is slightly dim, and tongue is slightly purple, the white root of tongue is slightly yellow thick, and arteries and veins omits number. Be diagnosed asThe obstruction of qi in the chest. Get 10 grams of Chinese juniper beach wormwoods, 5 grams of the tuber of pinellia, 10 grams of the dried immature fruit of citron oranges, 10 grams of cassia twig, 10 grams of balloonflower roots, the red sage root 10Gram, 10 grams of monkshoods, 10 grams, the dried rhizome of rehmannia, 10 grams of tendril-leaved fritillary bulb, 10 grams, peach kernel, 5 grams, safflower, 5 grams of Ligusticum wallichiis,3 grams of pearl powders, 5 grams of Radix Notoginseng powder, 10 grams of the shells of seaear, oral after decocting, separately get 5 grams of alumens, rheum officinale 5Gram, 5 grams of frankincenses, 5 grams of myrrhs, 5 grams of corydalis tubers, 5 grams of rattletops, 5 grams of borneols, 5 grams, Moschus, root tuber of aromatic turmeric 5Gram, make external application after ointment, treat three days short alleviating of metathorax sulks, sleep is slightly improved. Continue with after 7 days,The transference cure of breathing hard uncomfortable in chest, sleep take a turn for the better, and normal activity is unconsciously felt bad, no longer dizzy, and check electrocardiogram is aobviousShow and recover normal, clinical cure, Effect of follow-up visit by telephone has no recurrence half a year.
Case 2
Lee, female, 60 years old. Patient started conscious uncomfortable in chest without obvious inducement before 3 years, have an electro-cardiogram, cardiac muscleThe inspections such as zymogram, coronary artery CT, are diagnosed as hat venereal disease angina pectoris, and patient once takes Western medicine and controls under hospital instructsDeGrain after treating, and engender that back is ached, movable rear symptom increases the weight of. So attempt with weTreatment by Chinese herbs. Observe patient's white and greasy fur, tongue nature is partially purple, and tongue is slightly fat large, has a little indentation, and deep wiry pulse is sliding.Ginseng is closed in diagnosis by feeling the pulse, debates as hypofunction of YANG QI in chest, stagnation of liver qi, the resistance of train of thought numbness. Get 14 grams of Chinese juniper beach wormwoods, 9 grams of the tuber of pinellia, trifoliate orange14 grams of realities, 14 grams of cassia twig, 14 grams of balloonflower roots, 14 grams of the reds sage root, 14 grams of monkshoods, 14 grams, the dried rhizome of rehmannia, tendril-leaved fritillary bulb14 grams, 14 grams, peach kernel, 6 grams, safflower, 6 grams of Ligusticum wallichiis, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, the shell of seaear12 grams, oral after decocting, separately get 6 grams of alumens, 6 grams of rheum officinales, 6 grams of frankincenses, 6 grams of myrrhs, corydalis tuber 6Gram, 6 grams of rattletops, 6 grams of borneols, 6 grams, Moschus, 6 grams of root tubers of aromatic turmeric, make external application after ointment, treat 1After the course for the treatment of, readme scope uncomfortable in chest is obviously dwindled, and the symptom such as breathe hard uncomfortable in chest is improved, and back pain alleviates, soAfter will be with after treatment with 2 courses for the treatment of, all diseases all disappear, and hospital's check electrocardiogram recovers normal, follows up a case by regular visits to halfYear has no recurrence.
Case 3
Record certain, man, 64 years old. Patient suffers from coronary disease and angina pectoris and has a surplus for 10 years, and hospitalize is always difficult to rootControl, disease relapse, while outbreak at every turn, always there will be serious feel suffocated, the symptom such as uncomfortable in chest, pulse is uneven;And often have pale complexion, expiratory dyspnea, mood fear, the disease such as be in a cold sweat, and long-term taking Western medicine is not onlyDisease thoroughly could not be effected a radical cure, the side effect such as also often occur feeling sick, vomit, have a stomach-ache. Pushed away through friend afterwardsRecommend, start to take we's treatment. Get 20 grams of Chinese juniper beach wormwoods, 15 grams of the tuber of pinellia, 20 grams of the dried immature fruit of citron oranges, 20 grams of cassia twig,20 grams of balloonflower roots, 20 grams of the reds sage root, 20 grams of monkshoods, 20 grams, the dried rhizome of rehmannia, 20 grams of tendril-leaved fritillary bulb, 20 grams, peach kernel, redSpend 8 grams, 8 grams of Ligusticum wallichiis, 5 grams of pearl powders, 8 grams of Radix Notoginseng powder, 15 grams of the shells of seaear, after decocting, take, everyDay 2 times, separately get 8 grams of alumens, 8 grams of rheum officinales, 8 grams of frankincenses, 8 grams of myrrhs, 8 grams of corydalis tubers, rattletop 8Gram, 8 grams of borneols, 8 grams, Moschus, 8 grams of root tubers of aromatic turmeric, make external application after ointment, after 1 course for the treatment of, patient's readmeSymptom makes moderate progress, and chest distress etc. alleviate, after 2 courses for the treatment of, and the short obvious improvement of patient chest sulks, complexion is openedBegin ruddy, breathe smooth and easy, patient's exultation. Continue with 2 courses for the treatment of in addition after after treatment, symptom is significantly improved,Can live normally and move, follow up a case by regular visits to life so far and well, do not recur again.

Claims (7)

1. a Chinese medicine preparation for the treatment of coronary disease and angina pectoris, is characterized in that: in described Chinese medicine preparation comprisesTake medicine and medicine for external application, wherein:
Medicine for oral administration comprises: 10-20 gram of Chinese juniper beach wormwood, tuber of pinellia 5-15 gram, dried immature fruit of citron orange 10-20 gram, cassia twig 10-20 gram,Balloonflower root 10-20 gram, red sage root 10-20 gram, monkshood 10-20 gram, dried rhizome of rehmannia 10-20 gram, tendril-leaved fritillary bulb 10-20 gram,Peach kernel 10-20 gram, safflower 5-8 gram, Ligusticum wallichii 5-8 gram, pearl powder 3-5 gram, Radix Notoginseng powder 5-8 gram, stoneCassia tora 10-15 gram;
Medicine for external application comprises: alumen 5-8 gram, rheum officinale 5-8 gram, frankincense 5-8 gram, myrrh 5-8 gram, corydalis tuber5-8 gram, rattletop 5-8 gram, borneol 5-8 gram, Moschus 5-8 gram, root tuber of aromatic turmeric 5-8 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 10 grams of Chinese juniper beach wormwoods, 5 grams of the tuber of pinellia, 10 grams of the dried immature fruit of citron oranges, 10 grams of cassia twig, 10 grams of balloonflower roots,10 grams of the reds sage root, 10 grams of monkshoods, 10 grams, the dried rhizome of rehmannia, 10 grams of tendril-leaved fritillary bulb, 10 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii5 grams, 3 grams of pearl powders, 5 grams of Radix Notoginseng powder, 10 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 5 grams of rheum officinales, 5 grams of frankincenses, 5 grams of myrrhs, 5 grams of corydalis tubers, liter5 grams of fiber crops, 5 grams of borneols, 5 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
3. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 12 grams of Chinese juniper beach wormwoods, 7 grams of the tuber of pinellia, 12 grams of the dried immature fruit of citron oranges, 12 grams of cassia twig, 12 grams of balloonflower roots,12 grams of the reds sage root, 12 grams of monkshoods, 12 grams, the dried rhizome of rehmannia, 12 grams of tendril-leaved fritillary bulb, 12 grams, peach kernel, 5 grams, safflower, Ligusticum wallichii6 grams, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 11 grams of the shells of seaear;
Medicine for external application comprises: 5 grams of alumens, 6 grams of rheum officinales, 5 grams of frankincenses, 6 grams of myrrhs, 5 grams of corydalis tubers, liter6 grams of fiber crops, 5 grams of borneols, 6 grams, Moschus, 5 grams of root tubers of aromatic turmeric.
4. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 14 grams of Chinese juniper beach wormwoods, 9 grams of the tuber of pinellia, 14 grams of the dried immature fruit of citron oranges, 14 grams of cassia twig, 14 grams of balloonflower roots,14 grams of the reds sage root, 14 grams of monkshoods, 14 grams, the dried rhizome of rehmannia, 14 grams of tendril-leaved fritillary bulb, 14 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii6 grams, 3 grams of pearl powders, 6 grams of Radix Notoginseng powder, 12 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 6 grams of rheum officinales, 6 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter6 grams of fiber crops, 6 grams of borneols, 6 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
5. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 16 grams of Chinese juniper beach wormwoods, 11 grams of the tuber of pinellia, 16 grams of the dried immature fruit of citron oranges, 16 grams of cassia twig, 16 grams of balloonflower roots,16 grams of the reds sage root, 16 grams of monkshoods, 16 grams, the dried rhizome of rehmannia, 16 grams of tendril-leaved fritillary bulb, 16 grams, peach kernel, 6 grams, safflower, Ligusticum wallichii7 grams, 4 grams of pearl powders, 6 grams of Radix Notoginseng powder, 13 grams of the shells of seaear;
Medicine for external application comprises: 6 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 6 grams of myrrhs, 6 grams of corydalis tubers, liter7 grams of fiber crops, 6 grams of borneols, 7 grams, Moschus, 6 grams of root tubers of aromatic turmeric.
6. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 18 grams of Chinese juniper beach wormwoods, 13 grams of the tuber of pinellia, 18 grams of the dried immature fruit of citron oranges, 18 grams of cassia twig, 18 grams of balloonflower roots,18 grams of the reds sage root, 18 grams of monkshoods, 18 grams, the dried rhizome of rehmannia, 18 grams of tendril-leaved fritillary bulb, 18 grams, peach kernel, 7 grams, safflower, Ligusticum wallichii7 grams, 4 grams of pearl powders, 7 grams of Radix Notoginseng powder, 14 grams of the shells of seaear;
Medicine for external application comprises: 7 grams of alumens, 7 grams of rheum officinales, 7 grams of frankincenses, 7 grams of myrrhs, 7 grams of corydalis tubers, liter7 grams of fiber crops, 7 grams of borneols, 7 grams, Moschus, 7 grams of root tubers of aromatic turmeric.
7. Chinese medicine preparation according to claim 1, is characterized in that, this Chinese medicine preparation comprises medicine for oral administrationAnd medicine for external application, wherein:
Medicine for oral administration comprises: 20 grams of Chinese juniper beach wormwoods, 15 grams of the tuber of pinellia, 20 grams of the dried immature fruit of citron oranges, 20 grams of cassia twig, 20 grams of balloonflower roots,20 grams of the reds sage root, 20 grams of monkshoods, 20 grams, the dried rhizome of rehmannia, 20 grams of tendril-leaved fritillary bulb, 20 grams, peach kernel, 8 grams, safflower, Ligusticum wallichii8 grams, 5 grams of pearl powders, 8 grams of Radix Notoginseng powder, 15 grams of the shells of seaear;
Medicine for external application comprises: 8 grams of alumens, 8 grams of rheum officinales, 8 grams of frankincenses, 8 grams of myrrhs, 8 grams of corydalis tubers, liter8 grams of fiber crops, 8 grams of borneols, 8 grams, Moschus, 8 grams of root tubers of aromatic turmeric.
CN201610040202.8A 2016-01-21 2016-01-21 Traditional Chinese medicine preparation for treating angina pectoris of coronary heart disease Pending CN105582280A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114177229A (en) * 2021-12-14 2022-03-15 湖南农业大学 Medicine for influencing myocardial cell contraction or relaxation and determination method thereof

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CN1491683A (en) * 2002-10-21 2004-04-28 马德林 Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method
CN101062373A (en) * 2007-05-30 2007-10-31 张宪传 Chinese traditional medicinal preparation for treating coronary heart disease and angina pectoris
CN103041336A (en) * 2012-12-21 2013-04-17 孙红梅 Traditional Chinese medicine composition for treating coronary heart disease
CN104147335A (en) * 2014-08-17 2014-11-19 *** Traditional Chinese medicine preparation for treating thoracic obstruction

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Publication number Priority date Publication date Assignee Title
CN1030183A (en) * 1987-06-30 1989-01-11 马德林 A kind of manufacture method of preventing and treating the coronary heart disease medicine for external use
CN1491683A (en) * 2002-10-21 2004-04-28 马德林 Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method
CN101062373A (en) * 2007-05-30 2007-10-31 张宪传 Chinese traditional medicinal preparation for treating coronary heart disease and angina pectoris
CN103041336A (en) * 2012-12-21 2013-04-17 孙红梅 Traditional Chinese medicine composition for treating coronary heart disease
CN104147335A (en) * 2014-08-17 2014-11-19 *** Traditional Chinese medicine preparation for treating thoracic obstruction

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114177229A (en) * 2021-12-14 2022-03-15 湖南农业大学 Medicine for influencing myocardial cell contraction or relaxation and determination method thereof

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