CN105561393A - Amniotic membrane sclera lens support - Google Patents
Amniotic membrane sclera lens support Download PDFInfo
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- CN105561393A CN105561393A CN201610104878.9A CN201610104878A CN105561393A CN 105561393 A CN105561393 A CN 105561393A CN 201610104878 A CN201610104878 A CN 201610104878A CN 105561393 A CN105561393 A CN 105561393A
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- amniotic membrane
- scleroscope
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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Abstract
The invention relates to the field of bio-medical apparatus and instruments, in particular to an amniotic membrane sclera lens support. The amniotic membrane sclera lens support is of an elliptical and cyclic structure and made of a high- oxygen-permeation hard lens material with the oxygen permeation coefficient DK greater than 50. The amniotic membrane sclera lens support is fixedly covered with an amniotic membrane piece, so that an amniotic membrane sclera lens is obtained. The amniotic membrane sclera lens support can target at the characteristics of the eye structure of Asian people, the elliptical and cyclic structure is adopted, no pain is caused in the wearing process, generation of conjunctiva inflammation and scars is avoided, the treatment area is enlarged, the material of the support is moderate in hardness and good in oxygen permeation, wearing comfort and safety are greatly improved, and the practice that in a clinical operation, the amniotic membrane piece is sewed for treating ocular surface disease is substituted.
Description
Technical field
The present invention relates to biomedical devices field, particularly a kind of ophthalmology amniotic membrane scleroscope support.
Background technology
Amniotic membrane contains T suppression cell factor expression and regulates the composition of Apoptosis in cornea, the formation of the keratocyte brought out containing the T suppression cell factor and the hyperplasia of collagen fiber and new vessels; In ophthalmic applications, amnionic basement membrane can promote conjunctival stem cells to be divided into conjunctival epithelial cell, promote that conjunctival epithelium transforms to corneal epithelium, promotes limbal stem cell propagation and provides a microenvironment contributing to its growth, promoting that corneal epithelial cell is divided a word with a hyphen at the end of a line; Amniotic membrane has suppression fibrosis, lessen scar formation formed function, to the symblepharon caused by severe ocular surface disease and conjunctival cul-de-sac constriction very favourable.Amnion cell can secrete Multiple Antibodies, multiple lysozyme, and cracking body and complement have antiviral and bactericidal action; Compared with transplanting with Mucosa of lip, nasal mucosa, the risk occurring after transplanting to infect is less, and therefore amnion transplantation can be used for the reparation of multiple wound surface, as the graft flap coverage as skin burn, the substitute of artificial sheath, amniotic membrane contains the neural pain relieving factor, has the effect of pain relieving.Amniotic membrane is drawn materials easily, easy to use, can preserve for a long time at low temperatures, also can lyophilizing preserve.Because HLA-A, B or DR antigen or β2-microglobulin are not expressed in human amnion membrane surface; And express IB antigen, restriction IA antigen, the feature in these immunologys demonstrates amniotic membrane non-immunogenicity, hardly immunological rejection occurs after transplanting.
Amniotic membrane was just applied to surgery as a kind of dressing before more than 100 years, is applied in surgical skin transplant operation treats skin burn at the beginning of last century as a kind of donor material.Kim and Tseng to apply to the amniotic membrane preserved in rabbit corneal Reconstruction and after obtaining success in nineteen ninety-five, people start there has been brand-new, a deep understanding to the biological characteristics of amniotic membrane, amniotic membrane is more and more subject to the favor of ophthalmology worker, also more and more extensive, ripe in the clinical practice of ophthalmology.
Disclose the selection of amniotic membrane in patent US6152142, Making and banking, but only mention the application at ophthalmology general, without concrete technical scheme.Disclose the selection of amniotic membrane in patent US6326019B1, Making and banking, be referred to some embody rule at ophthalmology, but also without concrete technical scheme.The shape size of human eye has different, especially Asians and westerner eye shape and vary in size: westerner's eyelid is classified as 10.3
+1.2mm, Chinese's eyelid is classified as 9.7
+0.8mm; Westerner's corneal diameter average out to 11.79
+0.04mm, Chinese people is 11.4
+0.6mm.Amniotic membrane sclerotic ring material affects comfortable wearing degree, must be neither too hard, nor too soft, high oxygen flow degree; This patent does not mention the importance of these aspects of amniotic membrane sclerotic ring material, is that sheet is blank at present at Chinese amniotic membrane scleroscope.
Summary of the invention
The invention provides a kind of amniotic membrane scleroscope support, design for Asian's eyes feature, be applicable to very much Asian and wear, and feel more comfortable when wearing.
In order to realize above-mentioned technical purpose, a kind of amniotic membrane scleroscope of the present invention support, have employed following technical scheme:
A kind of amniotic membrane scleroscope support, this support is elliptical annular structure, and amniotic membrane scleroscope support adopts the hard mirror material of high oxygen flow to make, and the oxygen permeability coefficient DK value of the hard mirror material of described high oxygen flow is greater than 50.
Further improvement is: the major axis A of described amniotic membrane scleroscope support is 21-22mm, and minor axis B is 16-18mm, and height H is 2.5-3mm, and thickness T is 0.5mm.
Further improvement is: the major axis A of described amniotic membrane scleroscope support is 21-22mm, and minor axis B is 16-18mm, and height H is 2.5-3mm, and thickness T is 0.5mm, and radius of curvature R is 12-14mm, and horizontal plane minute surface width C is 0.26-0.33mm.
Further improvement is: the oxygen permeability coefficient DK value of the hard mirror material of described high oxygen flow is 50, and yang type modulus is less than 4MPa.
Further improvement is: the hard mirror material of described high oxygen flow is polymethyl acrylate or silicone-hydrogel.
Further improvement is: outer middle side part or the bottom of described amniotic membrane scleroscope support are provided with annular groove.
Further improvement is: also comprise membrane film, membrane film by and the closely sealed snap ring of described amniotic membrane scleroscope support or nontoxic and have the glue of bio-compatibility to cover to be fixed on described amniotic membrane scleroscope support.
Further improvement is: also comprise membrane film, and membrane film to cover on described amniotic membrane scleroscope support and extends to annular groove place, is fastened in annular groove is fixed on by membrane film on described amniotic membrane scleroscope support by rubber band.
Further improvement is: described rubber band adopts USP the 6th class material C lassVImaterials or meets FDA, and the material of 21CFR177.2600 is made.
A kind of amniotic membrane scleroscope support of the present invention, there is following technique effect: 1) amniotic membrane scleroscope support of the present invention, can for the feature of Asian's eye structure, by amniotic membrane scleroscope support Design ovalisation structure, can not pain be caused when wearing, there is wider clinical practice.2) amniotic membrane scleroscope support of the present invention have employed ellipsoidal structure, eye conjunctiva horizontal direction covers wider, avoids the generation of conjunctiva inflammation and cicatrix.3) high oxygen permeability hard mirror material polypropylene vinegar copolymer selected by its support of amniotic membrane scleroscope of the present invention, this material is by propylene vinegar and siliceous propylene vinegar, cross-linking agent and UV absorbent and a small amount of hydrophilic acrylic monomer, under inhaling at free radical the initiation sending out agent, high temperature copolymerization forms.Due to containing fluorine element and silica gel unit, make it such propylene vinegar material and there is good oxygen permeability (DK>50).Owing to adding a small amount of hydrophilic monomer in material, make the contact angle of material surface less (being less than 50 degree), thus this material anxiety cornea there is the good compatibility.(index of refraction: 1.42; Proportion: 1.25, yang type modulus is less than 4MPa), material is neither too hard, nor too soft in a word, greatly strengthen the comfortableness and safety worn.
Accompanying drawing explanation
Fig. 1 is the axonometric chart of amniotic membrane scleroscope support of the present invention;
Fig. 2 is the sectional view of the embodiment of the present invention one amniotic membrane scleroscope support;
Fig. 3 is the top view of the embodiment of the present invention one amniotic membrane scleroscope support;
Fig. 4 is the front view of the embodiment of the present invention two, three amniotic membrane scleroscope support;
Fig. 5 is the top view of the embodiment of the present invention two, three amniotic membrane scleroscope support;
Fig. 6 is the sectional view of the embodiment of the present invention two, three amniotic membrane scleroscope support;
Fig. 7 is the axonometric chart of the embodiment of the present invention four amniotic membrane scleroscope support;
Fig. 8 is the front view of the embodiment of the present invention four amniotic membrane scleroscope support
Fig. 9 is the front view of the embodiment of the present invention five amniotic membrane scleroscope support;
Figure 10 is the front view of the embodiment of the present invention six amniotic membrane scleroscope support;
Figure 11 is the front view of the embodiment of the present invention seven amniotic membrane scleroscope support;
Figure 12 is the embodiment of the present invention seven amniotic membrane scleroscope support annular groove place amplification view.
In figure: 1, annular groove; 2, membrane film; 3, snap ring; 4, rubber band.
Detailed description of the invention
Below in conjunction with accompanying drawing and detailed description of the invention, the present invention is described in further detail.
Embodiment one: as Figure 1-3, a kind of amniotic membrane scleroscope support, this support is elliptical annular structure, its major axis A is 21mm, and minor axis B is 16mm, and height H is 2.5mm, thickness T is 0.5mm, and amniotic membrane scleroscope support adopts high oxygen flow hard mirror material polymethyl acrylate to make.
Embodiment two: as Figure 4-Figure 6, a kind of amniotic membrane scleroscope support, this support is elliptical annular structure, its major axis A is 21mm, and minor axis B is 16mm, and height H is 2.5mm, thickness T is 0.5mm, horizontal plane minute surface broadband C is 0.26mm, and radius of curvature R is 12mm, and amniotic membrane scleroscope support adopts high oxygen flow hard mirror material polymethyl acrylate to make.
Embodiment three: as Figure 4-Figure 6, a kind of amniotic membrane scleroscope support, this support is elliptical annular structure, its major axis A is 22mm, and minor axis B is 18mm, and height H is 3mm, thickness T is 0.5mm, horizontal plane minute surface broadband C is 0.33mm, and radius of curvature R is 14mm, and amniotic membrane scleroscope support adopts high oxygen flow hard mirror material silicon hydrogel to make.
Embodiment four: as shown in Figure 7,8, a kind of amniotic membrane scleroscope support, this support is elliptical annular structure, its major axis A is 21.5mm, minor axis B is 17mm, height H is 2.8mm, thickness T is 0.5mm, horizontal plane minute surface broadband C is 0.3mm, radius of curvature R is that 13mm(sizing is see Fig. 5,6), amniotic membrane scleroscope support adopts high oxygen flow hard mirror material polymethyl acrylate to make, and be provided with annular groove 1 at the outer middle side part of amniotic membrane scleroscope support, annular groove 1 is 1.2mm from frame bottom distance D
Embodiment five: as shown in Figure 9, a kind of amniotic membrane scleroscope support, also comprise membrane film 2, amniotic membrane scleroscope support is elliptical annular structure, and its major axis A is 21mm, minor axis B is 16mm, height H is 2.5mm, and thickness T is 0.5mm, and horizontal plane minute surface broadband C is 0.26mm, radius of curvature R is that 12mm(sizing is see Fig. 5,6), amniotic membrane scleroscope support adopts high oxygen flow hard mirror material polymethyl acrylate to make.Membrane film 2 adopts lyophilizing amniotic membrane (also can adopt the membrane films such as artificial amniotic membrane), coat nontoxic in the side, outer ring of amniotic membrane scleroscope support elliptical ring and have bio-compatibility glue, surrounding corner is attached on the elliptical ring of amniotic membrane scleroscope support after lyophilizing amniotic membrane being covered amniotic membrane scleroscope support, finally by heat cure mode, lyophilizing amniotic membrane is fixed on amniotic membrane scleroscope support again.
Embodiment six: as shown in Figure 10, a kind of amniotic membrane scleroscope support, also comprise membrane film 2, amniotic membrane scleroscope support is elliptical annular structure, and its major axis A is 22mm, minor axis B is 18mm, height H is 3mm, and thickness T is 0.5mm, and horizontal plane minute surface broadband C is 0.33mm, radius of curvature R is that 14mm(sizing is see Fig. 5,6), amniotic membrane scleroscope support adopts high oxygen flow hard mirror material silicon hydrogel to make.Membrane film 2 can adopt lyophilizing amniotic membrane (also can adopt new living body amniotic membrane, or the bionic sheets such as artificial cornea), surrounding corner is wrapping on the elliptical ring of amniotic membrane scleroscope support after lyophilizing amniotic membrane being covered amniotic membrane scleroscope support, be enclosed within after snap ring 3 is added thermal expansion on the lyophilizing amniotic membrane being wrapping to amniotic membrane scleroscope support outer ring, just lyophilizing amniotic membrane be fixed on amniotic membrane scleroscope support after snap ring 3 cooling meat.
Embodiment seven: as shown in figure 11, a kind of amniotic membrane scleroscope support, also comprise membrane film 2, amniotic membrane scleroscope support is elliptical annular structure, its major axis A is 21.5mm, minor axis B is 17mm, height H is 2.8mm, thickness T is 0.5mm, horizontal plane minute surface broadband C is 0.3mm, radius of curvature R is that 13mm(sizing is see Fig. 5, 6), amniotic membrane scleroscope support adopts high oxygen flow hard mirror material polymethyl acrylate to make, annular groove 1 is provided with in the outside of amniotic membrane scleroscope support, annular groove 1 is that 1.2mm(sizing is see Fig. 8 from frame bottom distance D), membrane film 2 adopts bionical amniotic membrane or cornea (also can adopt the membrane films such as lyophilizing amniotic membrane), amniotic membrane scleroscope support annular groove 1 place is wrapping to after artificial amniotic membrane being covered amniotic membrane scleroscope support and by surrounding corner, be fastened in annular groove 1 li with a silicone rubber rubber band 4 thus bionical amniotic membrane be fixed on amniotic membrane scleroscope support, the amplification view at annular groove 1 place as shown in figure 12.
It is to be noted; above-mentioned embodiment is only the preferred embodiment of the invention, for those skilled in the art, under the prerequisite meeting operation principle of the present invention; do not limit concrete shape, any equivalent or similar replacement all falls within the scope of protection of the present invention.
Claims (9)
1. an amniotic membrane scleroscope support, is characterized in that: described amniotic membrane scleroscope support is elliptical annular structure, and amniotic membrane scleroscope support adopts the hard mirror material of high oxygen flow to make, and the oxygen permeability coefficient DK value of the hard mirror material of described high oxygen flow is greater than 50.
2. amniotic membrane scleroscope support according to claim 1, is characterized in that: the major axis A of described amniotic membrane scleroscope support is 21-22mm, and minor axis B is 16-18mm, and height H is 2.5-3mm, and thickness T is 0.5mm.
3. amniotic membrane scleroscope support according to claim 1, is characterized in that: the major axis A of described amniotic membrane scleroscope support is 21-22mm, and minor axis B is 16-18mm, height H is 2.5-3mm, thickness T is 0.5mm, and radius of curvature R is 12-14mm, and horizontal plane minute surface width C is 0.26-0.33mm.
4. amniotic membrane scleroscope support according to claim 1, is characterized in that: the oxygen permeability coefficient DK value of the hard mirror material of described high oxygen flow is 50, and yang type modulus is less than 4MPa.
5. amniotic membrane scleroscope support according to claim 4, is characterized in that: the hard mirror material of described high oxygen flow is polymethyl acrylate or silicone-hydrogel.
6. the amniotic membrane scleroscope support according to any one of claim 1-5, is characterized in that: outer middle side part or the bottom of described amniotic membrane scleroscope support are provided with annular groove (1).
7. the amniotic membrane scleroscope support according to any one of claim 1-5, it is characterized in that: also comprise membrane film (2), membrane film (2) by and the closely sealed snap ring (3) of described amniotic membrane scleroscope support or nontoxic and have the glue of bio-compatibility to cover to be fixed on described amniotic membrane scleroscope support.
8. amniotic membrane scleroscope support according to claim 6, it is characterized in that: also comprise membrane film (2), membrane film (2) to cover on described amniotic membrane scleroscope support and extends to annular groove (1) place, is fastened in that annular groove (1) is inner to be fixed on membrane film (2) on described amniotic membrane scleroscope support by rubber band (4).
9. amniotic membrane scleroscope support according to claim 8, is characterized in that: described rubber band (4) adopts USP the 6th class material C lassVImaterials or meets FDA, and the material of 21CFR177.2600 is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610104878.9A CN105561393A (en) | 2016-02-25 | 2016-02-25 | Amniotic membrane sclera lens support |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610104878.9A CN105561393A (en) | 2016-02-25 | 2016-02-25 | Amniotic membrane sclera lens support |
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| CN105561393A true CN105561393A (en) | 2016-05-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610104878.9A Pending CN105561393A (en) | 2016-02-25 | 2016-02-25 | Amniotic membrane sclera lens support |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021523811A (en) * | 2018-05-17 | 2021-09-09 | キョンブク ナショナル ユニバーシティ インダストリー−アカデミック コーオペレーション ファウンデーション | Partially cured contact lens type amniotic dressing and its manufacturing method |
| CN117679209A (en) * | 2023-12-25 | 2024-03-12 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Sewing-free biological amniotic membrane for eyes |
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| US6152142A (en) * | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| CN1652686A (en) * | 2002-03-14 | 2005-08-10 | 组织技术公司 | Amniotic membrane covering for a tissue surface and devices facilitating fastening of membranes |
| CN1927141A (en) * | 2006-08-31 | 2007-03-14 | 中山大学中山眼科中心 | Fixed device for eye surface biological film |
| CN201759734U (en) * | 2010-08-06 | 2011-03-16 | 沈素民 | Cornea protector |
| CN204192856U (en) * | 2014-11-06 | 2015-03-11 | 江西瑞济生物工程技术有限公司 | A kind of degradable eye maintenance device |
| CN204581690U (en) * | 2015-03-04 | 2015-08-26 | 范军华 | Bioamnion lamel |
| CN205698632U (en) * | 2016-02-25 | 2016-11-23 | 岳邦超 | A kind of amniotic membrane scleroscope support |
-
2016
- 2016-02-25 CN CN201610104878.9A patent/CN105561393A/en active Pending
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| US6152142A (en) * | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| CN1652686A (en) * | 2002-03-14 | 2005-08-10 | 组织技术公司 | Amniotic membrane covering for a tissue surface and devices facilitating fastening of membranes |
| CN1927141A (en) * | 2006-08-31 | 2007-03-14 | 中山大学中山眼科中心 | Fixed device for eye surface biological film |
| CN201759734U (en) * | 2010-08-06 | 2011-03-16 | 沈素民 | Cornea protector |
| CN204192856U (en) * | 2014-11-06 | 2015-03-11 | 江西瑞济生物工程技术有限公司 | A kind of degradable eye maintenance device |
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| CN205698632U (en) * | 2016-02-25 | 2016-11-23 | 岳邦超 | A kind of amniotic membrane scleroscope support |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021523811A (en) * | 2018-05-17 | 2021-09-09 | キョンブク ナショナル ユニバーシティ インダストリー−アカデミック コーオペレーション ファウンデーション | Partially cured contact lens type amniotic dressing and its manufacturing method |
| JP7141666B2 (en) | 2018-05-17 | 2022-09-26 | キョンブク ナショナル ユニバーシティ インダストリー－アカデミック コーオペレーション ファウンデーション | Partially cured contact lens type amniotic dressing and manufacturing method thereof |
| CN117679209A (en) * | 2023-12-25 | 2024-03-12 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Sewing-free biological amniotic membrane for eyes |
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