CN105561184A - Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof - Google Patents
Medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicinal composition for activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The medicinal composition comprises 260-300 parts of Ligusticum wallichii, 410-450 parts of Radix Astragali, 120-160 parts of panax notoginseng, 120-160 parts of cassia twig, 40-80 parts of Radix Aucklandiae, 120-160 parts of hawthorn fruit, 200-240 parts of Salvia miltiorrhiza, 120-160 parts of Rhizoma Alismatis, 40-80 parts of sophora flower, 120-160 parts of Radix Curcumae Aromaticae and 5-8 parts of borneol. The medicinal composition has the efficacy of activating blood circulation, dissipating blood stasis, warming meridians and relaxing veins, can be used to treat spirit dullness, hemiplegia, limb numbness, body cooling, unsmooth speech and other symptoms induced by cerebral thrombus and blood fat increase, and also has good effects on body temperature decrease, limb numbness and other symptoms; and a biological enzymatic hydrolysis, supercritical extraction, decoction and solvent normal temperature leaching technology combination extraction technology is adopted to extract raw materials with different qualities, so the dissolution of effective components of the medicines is greatly improved, and improvement of the quality of the above product is facilitated.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to one and there is blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian function, is used for the treatment of cerebral thrombosis, blood fat increases that the dull mind, hemiplegia, numb limbs and tense tendons, the health that cause are sent out cool, the medicine and preparation method thereof of the speech disease such as puckery late.
Background technology
Cardiovascular and cerebrovascular disease is exactly that cardiovascular and cerebrovascular disease are referred to as, and makes a general reference because ischemic or hemorrhage occur for the heart that hyperlipemia, blood are sticky, atherosclerosis, hypertension etc. cause, brain and body tissue.There is the feature of " sickness rate is high, mortality rate is high, disability rate is high, complication is many, relapse rate high ", the minimal invasive treatment of cardiovascular and cerebrovascular disease takes care of oneself difficulty, economy and mental pressure large, patient through therapy rehabilitation is much lost work and viability, the number of cardiovascular and cerebrovascular disease is died from every year up to 1,500 ten thousand people in the whole world, on average within every six minutes, just there is a people to die from cardiovascular and cerebrovascular disease, become the number one killer threatening human health.Along with the increase of rhythm of life and pressure, the increase of unhealthy eating and lifestyle habits, cardiovascular and cerebrovascular disease more presents the trend of rejuvenation, extension, and at present, China has had suffers from cardiovascular and cerebrovascular disease more than 2.7 hundred million people.
The chemicals of current Cardiovarscular is more, but toxic side effect is large, dependency is strong, stimulate digestion and nervous system, be difficult to the shortcomings such as basic healing.Therefore the Chinese medicine of development of new blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian is the important directions of Cardiovarscular.
Summary of the invention
The invention provides a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian and preparation method thereof, be used for the treatment of cerebral thrombosis, blood fat increase that the dull mind, hemiplegia, numb limbs and tense tendons, the health that cause are sent out cool, the speech symptom such as puckery late, wherein Chinese medicine composition of the present invention (XIAOSHUAN TONGLUO PIAN) has good effect to the symptom such as temperature decline, numb limbs and tense tendons
The many relations from gas and blood of theory of Chinese medical science explain cardiovascular and cerebrovascular disease, qi depression to blood stasis, and negative and positive of qi and blood disorder imbalance is the major reason causing cardiovascular and cerebrovascular disease.Theory of Chinese medical science have " qi as the commander of blood ", saying of " blood being gas internal organs ", what the former said is the effect of gas to blood, i.e. qi promoting blood production, QI can promote blood circulation, QI can control blood three parts, the nutrient substance of human consumption or smart unit are converted to the effect all be unableing to do without gas of blood, are again the power of blood with seasonal epidemic pathogens, " gas is capable is blood flow " is recorded in " generation of Plain Questions the five internal organs ", QI movement being in harmonious way, blood could be normal, so-called " stagnation of QI is blood stasis then "; Astringency inducing effect with seasonal epidemic pathogens makes blood not overflow outside venation, as said in " treatise on blood trouble pathogenesis of Zong-Fu diseases opinion " " life of the person, in a word with gas system blood "; " blood is gas internal organs " refers to the effect of blood to gas, comprise blood energy anger, blood can carry QI, namely the generation providing gas by blood and the nutrient substance played needed for physiological function, it is the source of nutrition of gas, gas arrives whole body, and each is realized by the delivery of blood through normal pulse organ, as described in " symposium on medical topics 30 sections ": " gas sun and blood is cloudy, blood is not only, and bad gas is with life; Gas without appended, rely blood with attached it ", blood can also suppress laxing of gas not received as can be seen here.Through QI-insufficiency, hematogenous blockage, will inevitably cause venation block, and then forms thromboembolism.Although some XIAOSHUAN TONGLUO PIAN of selling on the market at present it is reported can to cardiovascular and cerebrovascular disease curative effect to some extent, but in all reports of the research about XIAOSHUAN TONGLUO PIAN, almost do not mention the symptoms such as its temperature decline caused cardiovascular and cerebrovascular disease, numb limbs and tense tendons to possess some special knowledge and effect, and temperature decline seriously can cause human chitinase vigor to change, metabolic function is disorderly, and numb limbs and tense tendons can cause patient handicapped especially, difficulty of taking care of oneself, psychological burden increases the weight of
The Chinese medicine composition that the present invention relates to reuses Radix Notoginseng, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Crataegi, get that its activating QI to alleviate the depression, method wind-dryness are wet, dissipating blood stasis hemostasis, subduing swelling and relieving pain, removing heat from blood eliminating carbuncle effect, the blood pressure lowering of Flos Sophorae removing heat from blood, Radix Curcumae promoting QI circulation for relieving depression, Radix Aucklandiae spleen invigorating intestinal stasis relieving, Borneolum Syntheticum removing heat from the heart to restore the consciousness are the ministerial drug of auxiliary monarch altogether, more be equipped with that Rhizoma Alismatis dehumidifying expels the heat-evil, Ramulus Cinnamomi complement sun, logical blood warm up spleen, Radix Astragali consolidating superficial resistance QI invigorating, altogether for Fang Zhongzuo makes, all medicines share blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.
The technical scheme that the present invention takes is: be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 260-300 part, Radix Astragali 410-450 part, Radix Notoginseng 120-160 part, Ramulus Cinnamomi 120-160 part, Radix Aucklandiae 40-80 part, Fructus Crataegi 120-160 part, Radix Salviae Miltiorrhizae 200-240 part, Rhizoma Alismatis 120-160 part, Flos Sophorae 40-80 part, Radix Curcumae 120-160 part, Borneolum Syntheticum 5-8 part.
Preferred:
Rhizoma Chuanxiong 280 parts, the Radix Astragali 430 parts, Radix Notoginseng 140 parts, Ramulus Cinnamomi 140 parts, the Radix Aucklandiae 60 parts, Fructus Crataegi 140 parts, Radix Salviae Miltiorrhizae 220 parts, Rhizoma Alismatis 140 parts, 60 parts, Flos Sophorae, Radix Curcumae 140 parts, Borneolum Syntheticum 6.5 parts
The preparation method of pharmaceutical composition effective ingredient of the present invention comprises the following steps:
(1) get Rhizoma Chuanxiong in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation to extract 1-5 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(2) get the Radix Astragali in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation to extract 1-5 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(3) get Radix Notoginseng in proportion, the ethanol adding 1-50 times of 10%-99% extracts, and each 1-5 hour extracts 1-5 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(4) get Ramulus Cinnamomi in proportion, add 1-25 soak by water doubly 1-5 time, each 1-5 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentrates to obtain extractum;
(5) get the Radix Aucklandiae in proportion, be ground into coarse powder, add 1-10 times of warm water, within vapor distillation 1-20 hour, extract volatile oil, lyophilization, for subsequent use;
(6) get Fructus Crataegi in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation extracts 1-5 time, collects volatile oil, medical filtration, and filtrate merges, and after using flash distillation instrument to concentrate, adds ethanol hold over night, uses high speed centrifuge centrifugal, filters, and reclaims filtrate and concentrates to obtain extractum;
(7) get Radix Salviae Miltiorrhizae in proportion, add 1-25 soak by water doubly 1-5 time, each 1-5 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentrates to obtain extractum;
(8) get Rhizoma Alismatis in proportion, the ethanol adding 1-50 times of 10%-99% extracts, and each 1-5 hour extracts 1-5 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(9) get Flos Sophorae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1-10%, extracting pressure 5-40MPa, temperature 10-50 DEG C, CO
2flow 1-5ml/g crude drug min, extraction time 100-180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
(10) get Radix Curcumae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1-10%, extracting pressure 5-40MPa, temperature 10-50 DEG C, CO
2flow 1-5ml/g crude drug min, extraction time 100-180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
Use closed pulverizer to be pulverized by above-mentioned substance, add Borneolum Syntheticum mixing, use rotary tablet machine to be pressed into the tablet of 0.38g/ sheet.
The ratio of step of the present invention (one) compound enzyme cellulase and pectase is 1:1.
The ratio of step of the present invention (two) compound enzyme cellulase and pectase is 1:1.
The ratio of step of the present invention (six) compound enzyme cellulase and pectase is 1:1.
The present invention has blood circulation promoting and blood stasis dispelling, effect of promoting the flow of QI in the collateral by warming the meridian, can be used for treating that cerebral thrombosis, blood fat increase that the dull mind, hemiplegia, numb limbs and tense tendons, the health that cause are sent out cool, the speech symptom such as puckery late, also have good effect to the symptom such as temperature decline, numb limbs and tense tendons; And adopt biological enzymolysis respectively, supercritical extraction according to raw material quality difference, decoct, the leach extraction method that the technological means such as solvent room temperature leaching combine, substantially increases the dissolution of effective ingredient, is conducive to the raising of product quality.
Detailed description of the invention
Embodiment 1
Be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 260 parts, the Radix Astragali 410 parts, Radix Notoginseng 120 parts, Ramulus Cinnamomi 120 parts, the Radix Aucklandiae 40 parts, Fructus Crataegi 120 parts, Radix Salviae Miltiorrhizae 200 parts, Rhizoma Alismatis 120 parts, 40 parts, Flos Sophorae, Radix Curcumae 120, Borneolum Syntheticum 5 parts;
The preparation method of pharmaceutical composition effective ingredient of the present invention comprises the following steps:
(1) get Rhizoma Chuanxiong in proportion, add the compound enzyme containing cellulase and pectase of 1%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 1 times amount, mixing, and 40 DEG C are incubated enzymolysis 1 hour; Moisturizing, use steam distillation to extract 1 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(2) get the Radix Astragali in proportion, add the compound enzyme containing cellulase and pectase of 1%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 1 times amount, mixing, and 40 DEG C are incubated enzymolysis 1 hour; Moisturizing, use steam distillation to extract 1 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(3) get Radix Notoginseng in proportion, the ethanol adding 1 times 10% extracts, each 1 hour, extracts 1 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(4) get Ramulus Cinnamomi in proportion, add the soak by water 1 time of 1 times, each 1 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(5) get the Radix Aucklandiae in proportion, be ground into coarse powder, add 1 times of warm water, vapor distillation extracts volatile oil, lyophilization in 1 hour, for subsequent use;
(6) get Fructus Crataegi in proportion, add the compound enzyme containing cellulase and pectase of 1%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 1 times amount, mixing, and 40 DEG C are incubated enzymolysis 1 hour; Moisturizing, use steam distillation to extract 1 time, collect volatile oil, medical filtration, filtrate merges, and after using flash distillation instrument to concentrate, adds ethanol hold over night, uses high speed centrifuge centrifugal, filters, and reclaims filtrate and concentrates to obtain extractum;
(7) get Radix Salviae Miltiorrhizae in proportion, add the soak by water 1 time of 1 times, each 1 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(8) get Rhizoma Alismatis in proportion, the ethanol adding 1 times 10% extracts, each 1 hour, extracts 1 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(9) get Flos Sophorae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1%, extracting pressure 5MPa, temperature 10 DEG C, CO
2flow 1ml/g crude drug min, extraction time 100min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
(10) get Radix Curcumae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1%, extracting pressure 5MPa, temperature 10 DEG C, CO
2flow 1ml/g crude drug min, extraction time 100min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
Use closed pulverizer to be pulverized by above-mentioned substance, add Borneolum Syntheticum mixing, use rotary tablet machine to be pressed into the tablet of 0.38g/ sheet.
Embodiment 2
Be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 280 parts, the Radix Astragali 430 parts, Radix Notoginseng 140 parts, Ramulus Cinnamomi 140 parts, the Radix Aucklandiae 60 parts, Fructus Crataegi 140 parts, Radix Salviae Miltiorrhizae 220 parts, Rhizoma Alismatis 140 parts, 60 parts, Flos Sophorae, Radix Curcumae 140 parts, Borneolum Syntheticum 6.5 parts.
The preparation method of pharmaceutical composition effective ingredient of the present invention comprises the following steps:
(1) get Rhizoma Chuanxiong in proportion, add the compound enzyme containing cellulase and pectase of 5.5%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 5.5 times amount, mixing, and 50 DEG C are incubated enzymolysis 3 hours; Moisturizing, use steam distillation to extract 3 times, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(2) get the Radix Astragali in proportion, add the compound enzyme containing cellulase and pectase of 5.5%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 5.5 times amount, mixing, and 50 DEG C are incubated enzymolysis 3 hours; Moisturizing, use steam distillation to extract 3 times, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(3) get Radix Notoginseng in proportion, the ethanol adding 25 times 55% extracts, each 3 hours, extracts 3 times, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(4) get Ramulus Cinnamomi in proportion, add the soak by water 3 times of 13 times, each 3 hours, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(5) get the Radix Aucklandiae in proportion, be ground into coarse powder, add 5.5 times of warm water, vapor distillation extracts volatile oil, lyophilization in 10.5 hours, for subsequent use;
(6) get Fructus Crataegi in proportion, add the compound enzyme containing cellulase and pectase of 5.5%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 5.5 times amount, mixing, and 50 DEG C are incubated enzymolysis 3 hours; Moisturizing, use steam distillation to extract 3 times, collect volatile oil, medical filtration, filtrate merges, and after using flash distillation instrument to concentrate, adds ethanol hold over night, uses high speed centrifuge centrifugal, filters, and reclaims filtrate and concentrates to obtain extractum;
(7) get Radix Salviae Miltiorrhizae in proportion, add the soak by water 3 times of 13 times, each 3 hours, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(8) get Rhizoma Alismatis in proportion, the ethanol adding 25 times 55% extracts, each 3 hours, extracts 3 times, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(9) get Flos Sophorae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5.5%, extracting pressure 22MPa, temperature 30 DEG C, CO
2flow 3ml/g crude drug min, extraction time 140min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
(10) get Radix Curcumae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5.5%, extracting pressure 22MPa, temperature 30 DEG C, CO
2flow 3ml/g crude drug min, extraction time 140min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
Use closed pulverizer to be pulverized by above-mentioned substance, add Borneolum Syntheticum mixing, use rotary tablet machine to be pressed into the tablet of 0.38g/ sheet.
Embodiment 3
Be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 300 parts, the Radix Astragali 450 parts, Radix Notoginseng 160 parts, Ramulus Cinnamomi 160 parts, the Radix Aucklandiae 80 parts, Fructus Crataegi 160 parts, Radix Salviae Miltiorrhizae 240 parts, Rhizoma Alismatis 160 parts, 80 parts, Flos Sophorae, Radix Curcumae 160 parts, Borneolum Syntheticum 8 parts;
The preparation method of pharmaceutical composition effective ingredient of the present invention comprises the following steps:
(1) get Rhizoma Chuanxiong in proportion, add the compound enzyme containing cellulase and pectase of 10%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 10 times amount, mixing, and 60 DEG C are incubated enzymolysis 5 hours; Moisturizing, use steam distillation to extract 5 times, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(2) get the Radix Astragali in proportion, add the compound enzyme containing cellulase and pectase of 10%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 10 times amount, mixing, and 60 DEG C are incubated enzymolysis 5 hours; Moisturizing, use steam distillation to extract 5 times, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(3) get Radix Notoginseng in proportion, the ethanol adding 50 times 99% extracts, each 5 hours, extracts 5 times, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(4) get Ramulus Cinnamomi in proportion, add the soak by water 5 times of 25 times, each 5 hours, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(5) get the Radix Aucklandiae in proportion, be ground into coarse powder, add 10 times of warm water, vapor distillation extracts volatile oil, lyophilization in 20 hours, for subsequent use;
(6) get Fructus Crataegi in proportion, add the compound enzyme containing cellulase and pectase of 10%, the ratio of its cellulase and pectase is 1:1, adds the warm water of 10 times amount, mixing, and 60 DEG C are incubated enzymolysis 5 hours; Moisturizing, use steam distillation to extract 5 times, collect volatile oil, medical filtration, filtrate merges, and after using flash distillation instrument to concentrate, adds ethanol hold over night, uses high speed centrifuge centrifugal, filters, and reclaims filtrate and concentrates to obtain extractum;
(7) get Radix Salviae Miltiorrhizae in proportion, add the soak by water 5 times of 25 times, each 5 hours, use high speed centrifuge centrifugal, filter, merging filtrate also concentratedly to obtain extractum;
(8) get Rhizoma Alismatis in proportion, the ethanol adding 50 times 99% extracts, each 5 hours, extracts 5 times, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(9) get Flos Sophorae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 10%, extracting pressure 40MPa, temperature 50 C, CO
2flow 5ml/g crude drug min, extraction time 180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
(10) get Radix Curcumae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 10%, extracting pressure 40MPa, temperature 50 C, CO
2flow 5ml/g crude drug min, extraction time 180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
Use closed pulverizer to be pulverized by above-mentioned substance, add Borneolum Syntheticum mixing, use rotary tablet machine to be pressed into the tablet of 0.38g/ sheet.
Effect of the present invention is further illustrated below by pharmacodynamic experiment.
1 experiment material
1.1 laboratory animal
Kun Ming mice, body weight 18-22g, male and female half and half, are provided by Jilin University's biotic experiment center.
1.2 experimental drug
Medicine of the present invention, hereinafter referred to as XIAOSHUAN TONGLUO PIAN, is provided by JiLin ZiXin Pharmacy Co., Ltd
Pentobarbital sodium, by Beijing, Pu Bosi bio tech ltd provides
Normal saline, medical alcohol, distilled water
1.3 experiment equipment
Scalpel, surgical scissors, clinical thermometer, surgeon's knot binding, injector for medical purpose, mice rotation test system (revolving excellent instrument), electronic analytical balance, mouse stomach pin, volumetric flask, Glass rod, beaker, graduated cylinder
2 test methods and result
120 Kun Ming mice are bought from Jilin University's biotic experiment center, male and female half and half, each 18-22g, physical health, action is active, room temperature 25 DEG C, raise in the Mouse feeder laboratory of relative humidity 50%-60%, use special feed and water to feed, illumination every day and interlunation half and half, ad lib drinking-water one week, to conform.Study from mouse temperature, reaction sensitivity (numb limbs and tense tendons), thrombosis length three aspects.Experimental data represents with mean ± standard deviation (x ± s), and between employing group, statistical analysis is carried out in t inspection.
2.1 XIAOSHUAN TONGLUO PIAN are on the impact of mouse temperature
Get 40 healthy mices, male and female half and half, be respectively blank group, the basic, normal, high dosage group of XIAOSHUAN TONGLUO PIAN, often organize ten, male and female half and half, press table 1 dosage gastric infusion respectively, blank group uses distilled water gavage, successive administration five days, lumbar injection 50mg/ml pentobarbital sodium is anaesthetized, surgical ligation postcava, sew up after 5 hours, test mice anus body temperature.
Table 1 XIAOSHUAN TONGLUO PIAN is on the impact of mouse temperature
| Group | Mice quantity | Drug dose (g/kg) | Body temperature |
| Matched group | 10 | - | 36.02±0.52 |
| Low dose group | 10 | 3 | 36.29±0.50 ** |
| Middle dosage group | 10 | 6 | 36.52±0.66 ** |
| High dose group | 10 | 12 | 36.80±0.86 ** |
Note: compare with negative control, * P<0.05, * * P<0.01
Known by experiment, the effect of the temperature decline that XIAOSHUAN TONGLUO PIAN has significantly treatment thrombosis to cause.
2.2 XIAOSHUAN TONGLUO PIAN are on the impact of mice reaction sensitivity
Get 40 healthy mices, male and female half and half, be respectively blank group, the basic, normal, high dosage group of XIAOSHUAN TONGLUO PIAN, often organize ten, male and female half and half, press table 2 dosage gastric infusion respectively, blank group uses distilled water gavage, successive administration five days, lumbar injection 50mg/ml pentobarbital sodium is anaesthetized, surgical ligation postcava, sew up after 5 hours, use and revolve excellent instrument test mice reaction sensitivity.
Table 2 XIAOSHUAN TONGLUO PIAN is on the impact of mice reaction sensitivity
Note: compare with negative control, * P<0.05, * * P<0.01
Known by experiment, the effect of the numb limbs and tense tendons that XIAOSHUAN TONGLUO PIAN has treatment thrombosis to cause.
2.3 XIAOSHUAN TONGLUO PIAN are on the impact of mice thrombosis length
Get 40 healthy mices, male and female half and half, be respectively blank group, the basic, normal, high dosage group of XIAOSHUAN TONGLUO PIAN, often organizes ten, male and female half and half, press table 3 dosage gastric infusion respectively, blank group uses distilled water gavage, successive administration five days, lumbar injection 50mg/ml pentobarbital sodium is anaesthetized, and surgical ligation postcava, sewed up after 10 hours, again surgical incision abdominal cavity, removal of thromboses is numbered, and weighs weight in wet base, be placed in 50 DEG C of baking ovens again to dry, after cooling, weigh dry weight.
Table 3 XIAOSHUAN TONGLUO PIAN is on the impact of mice reaction sensitivity
Note: compare with negative control, * P<0.05, * * P<0.01
Known by experiment, XIAOSHUAN TONGLUO PIAN has effect of inhibition thrombosis and expansion.
Prove by experiment, Chinese medicine composition XIAOSHUAN TONGLUO PIAN of the present invention has inhibition thrombosis and development and treats effect such as temperature decline, numb limbs and tense tendons that thrombosis causes.
Claims (6)
1. for a pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian, it is characterized in that: be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 260-300 part, Radix Astragali 410-450 part, Radix Notoginseng 120-160 part, Ramulus Cinnamomi 120-160 part, Radix Aucklandiae 40-80 part, Fructus Crataegi 120-160 part, Radix Salviae Miltiorrhizae 200-240 part, Rhizoma Alismatis 120-160 part, Flos Sophorae 40-80 part, Radix Curcumae 120-160 part, Borneolum Syntheticum 5-8 part.
2. a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian according to claim 1, is characterized in that: be made up of the raw material of following parts by weight:
Rhizoma Chuanxiong 280 parts, the Radix Astragali 430 parts, Radix Notoginseng 140 parts, Ramulus Cinnamomi 140 parts, the Radix Aucklandiae 60 parts, Fructus Crataegi 140 parts, Radix Salviae Miltiorrhizae 220 parts, Rhizoma Alismatis 140 parts, 60 parts, Flos Sophorae, Radix Curcumae 140 parts, Borneolum Syntheticum 6.5 parts.
3. the preparation method of a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian as claimed in claim 1 or 2, is characterized in that comprising the following steps:
(1) get Rhizoma Chuanxiong in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation to extract 1-5 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(2) get the Radix Astragali in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation to extract 1-5 time, collect volatile oil, medical filtration, filtrate merges, and after use flash distillation instrument is concentrated, adds a large amount of ethanol hold over night, uses high speed centrifuge centrifugal, then filters, and reclaims filtrate and concentrates to obtain extractum;
(3) get Radix Notoginseng in proportion, the ethanol adding 1-50 times of 10%-99% extracts, and each 1-5 hour extracts 1-5 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(4) get Ramulus Cinnamomi in proportion, add 1-25 soak by water doubly 1-5 time, each 1-5 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentrates to obtain extractum;
(5) get the Radix Aucklandiae in proportion, be ground into coarse powder, add 1-10 times of warm water, within vapor distillation 1-20 hour, extract volatile oil, lyophilization, for subsequent use;
(6) get Fructus Crataegi in proportion, add the compound enzyme containing cellulase and pectase of 1%-10%, add the warm water of 1-10 times amount, mixing, 40-60 DEG C of insulation enzymolysis 1-5 hour; Moisturizing, use steam distillation extracts 1-5 time, collects volatile oil, medical filtration, and filtrate merges, and after using flash distillation instrument to concentrate, adds ethanol hold over night, uses high speed centrifuge centrifugal, filters, and reclaims filtrate and concentrates to obtain extractum;
(7) get Radix Salviae Miltiorrhizae in proportion, add 1-25 soak by water doubly 1-5 time, each 1-5 hour, use high speed centrifuge centrifugal, filter, merging filtrate also concentrates to obtain extractum;
(8) get Rhizoma Alismatis in proportion, the ethanol adding 1-50 times of 10%-99% extracts, and each 1-5 hour extracts 1-5 time, and use high speed centrifuge centrifugal, filter, merging filtrate concentrates, and grinds powdered after lyophilization, for subsequent use;
(9) get Flos Sophorae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1-10%, extracting pressure 5-40MPa, temperature 10-50 DEG C, CO
2flow 1-5m1/g crude drug min, extraction time 100-180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
(10) get Radix Curcumae in proportion, join CO
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 1-10%, extracting pressure 5-40MPa, temperature 10-50 DEG C, CO
2flow 1-5m1/g crude drug min, extraction time 100-180min, obtains supercritical extract, concentrated by rotary evaporation, lyophilization;
Use closed pulverizer to be pulverized by above-mentioned substance, add Borneolum Syntheticum mixing, use rotary tablet machine to be pressed into the tablet of 0.38g/ sheet.
4. the preparation method of a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian according to claim 3, is characterized in that: the ratio of described step (one) compound enzyme cellulase and pectase is 1:1.
5. the preparation method of a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian according to claim 3, is characterized in that: the ratio of described step (two) compound enzyme cellulase and pectase is 1:1.
6. the preparation method of a kind of pharmaceutical composition for blood circulation promoting and blood stasis dispelling promoting the flow of QI in the collateral by warming the meridian according to claim 3, is characterized in that: the ratio of described step (six) compound enzyme cellulase and pectase is 1:1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066702A (en) * | 2016-11-29 | 2018-05-25 | 陕西步长制药有限公司 | A kind of Chinese medicine preparation for treating syndrome of blood stasis due to qi deficiency and preparation method thereof |
| CN108552495A (en) * | 2017-12-12 | 2018-09-21 | 常州金艺广告传媒有限公司 | A kind of preparation method of blood-circulation and removing blood stasis ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103495117A (en) * | 2013-10-09 | 2014-01-08 | 南京正亮医药科技有限公司 | Preparation method and application of thrombus removing and collaterals dredging tablets |
| CN104856968A (en) * | 2015-05-27 | 2015-08-26 | 韩志强 | Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103495117A (en) * | 2013-10-09 | 2014-01-08 | 南京正亮医药科技有限公司 | Preparation method and application of thrombus removing and collaterals dredging tablets |
| CN104856968A (en) * | 2015-05-27 | 2015-08-26 | 韩志强 | Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108066702A (en) * | 2016-11-29 | 2018-05-25 | 陕西步长制药有限公司 | A kind of Chinese medicine preparation for treating syndrome of blood stasis due to qi deficiency and preparation method thereof |
| CN108066702B (en) * | 2016-11-29 | 2020-04-14 | 陕西步长制药有限公司 | Traditional Chinese medicine preparation for treating qi deficiency and blood stasis syndrome and preparation method thereof |
| CN108552495A (en) * | 2017-12-12 | 2018-09-21 | 常州金艺广告传媒有限公司 | A kind of preparation method of blood-circulation and removing blood stasis ointment |
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