CN105561004A - Traditional Chinese medicine composition for preventing and treating chronic nephritis - Google Patents
Traditional Chinese medicine composition for preventing and treating chronic nephritis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and treating chronic nephritis. The traditional Chinese medicine composition is prepared from, by weight, 15-35 parts of lalang grass rhizomes, 10-30 parts of poria cocos, 10-25 parts of panax notoginseng, 10-25 parts of rhizoma cyperi, 10-30 parts of herba clerodendranthi spicati, 10-25 parts of peach seeds, 5-20 parts of hyperici perforati herba, 5-25 parts of rhizoma alismatis, 10-20 parts of prepared rhizome of adhesive rehmannia, 10-35 parts of fructus ligustri lucidi, 5-25 parts of Chinese arborvitae twigs and 5-20 parts of radix codonopsis. The traditional Chinese medicine composition has the effects of inducing diuresis, promoting qi circulation, promoting blood circulation to remove blood stasis, clearing heat, removing toxicity, dispelling wind and eliminating dampness and is used for preventing and treating the chronic nephritis, no toxic and side effect exists, and the effect is significant.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, in particular to a kind of Chinese medicine composition of prevention and therapy chronic nephritis.
Background technology
Chronic nephritis clinical characters is that the course of disease is long, slower development, symptom can gently can weigh, and has asymptomatic urine examination anomalistic period more, then occurs edema in various degree, albuminuria, microscopic hematuria, can accompanied with hypertension and (or) azotemia, and the renal function injury that Progressive symmetric erythrokeratodermia increases the weight of.Chronic kidney disease in the world sickness rate raises year by year, high with its case fatality rate, treatment cost, the feature serious harm human healths such as awareness, cure rate are low, poor prognosis, the sickness rate of chronic nephritis is more and more higher in recent years, more and more rejuvenation, bring huge financial burden to country and individual, property nephritis is clinical department of internal medicine refractory disease, finally can develop into renal failure, patient has to accept renal replacement therapies.
Albuminuria is one of the modal clinical manifestation of CGN and the index that can detect the earliest; a large amount of Clinical and experimental studies finds; urine protein itself has nephrotoxicity; be carry out renal failure one lastingly, independently degradation factors; it is a kind of important symbol of CGN prognosis mala; so reduce and eliminate albuminuria, be one of important measures of protection renal function.Treatment chronic nephritis does not mainly recur, and its traditional treatment measure adopts general treatment and hormone, immunosuppressant treatment etc. usually.Due to repeatability and strong side effect, increasing people repels hormone, immunosuppressant class Chinese medicine composition, needs new chronic nephritis Therapeutic Method.
Chronic nephritis belongs to the category such as the traditional Chinese medical science " edema ", " asthenia ", " lumbago ", " hematuria " according to clinical manifestation.Ancient Chinese medicine doctor all think the cause of disease of edema and hematuria and diseases caused by exogenous pathogenic factor six because of in " ailment said due to cold or exposure ", " water wets " is relevant." edema due to wind pathogen " that "Nei Jing" proposes is similar with the kidney disease caused by external ailment said due to cold or exposure, " Plain Questions hydro-thermal cave opinion " points out that the reason causing edema due to wind pathogen is: " brave and labor very; then kidney sweating, exposure to the wind after sweating involving in the kidney, interiorly must not enter internal organs; outward must not more in skin; visitor is in Xuan Fu, and row, in flesh side, passes as carbuncle; basis in kidney, name says edema due to wind pathogen "." General Treatise on the Cause and Symptoms of Diseases " is said: " ailment said due to cold or exposure enters few the moon then hematuria ".Visible ailment said due to cold or exposure, water wet the importance in morbidity.Wet the lying hidden and undeveloped of water is not changed, with the passing of time heat-transformation, and heat is closed with wet, just becomes damp and hot card, and thus, water is wet is wet thermogenetic basis.Blood stasis is also lead edematigenous key factor, as said in " Medical Treasures of the Golden Chamber ": " menstruation disorder is then water ", and " treatise on blood trouble " is pointed out: " blood and water not from ", " multiple abscess due to blood stasis also flood swollen person, be the card that blood becomes water ".Chronic nephritis is once occur thus, and namely create damp and hot and blood stasis, namely both be pathological product, and be again paathogenic factor, and influence each other, blood stasis increases the weight of damp and hot, and damp and hot obstruction blood, causes state of an illness sustainable development, and delay is difficult.
Summary of the invention
The invention provides a kind of Chinese medicine composition of prevention and therapy chronic nephritis, this Chinese medicine composition has effect of diuretic circulation of qi promoting, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, expelling wind and removing dampness, for prevention and therapy chronic nephritis, has no side effect, Be very effective.
Concrete, one aspect of the present invention provides a kind of Chinese medicine composition of prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 15-35 part, Poria 10-30 part, Radix Notoginseng 10-25 part, Rhizoma Cyperi 10-25 part, kidney tea 10-30 part, Semen Persicae 10-25 part, Herba Hyperici Monogyni 5-20 part, Rhizoma Alismatis 5-25 part, Radix Rehmanniae Preparata 10-20 part, Fructus Ligustri Lucidi 10-35 part, Cacumen Platycladi 5-25 part, Radix Codonopsis 5-20 part.
In the embodiment that the present invention one is concrete, the Chinese medicine composition of described a kind of prevention and therapy chronic nephritis is made up of the crude drug of following weight portion: Rhizoma Imperatae 20-35 part, Poria 10-25 part, Radix Notoginseng 15-25 part, Rhizoma Cyperi 10-20 part, kidney tea 10-25 part, Semen Persicae 15-25 part, Herba Hyperici Monogyni 15-20 part, Rhizoma Alismatis 10-25 part, Radix Rehmanniae Preparata 10-15 part, Fructus Ligustri Lucidi 10-20 part, Cacumen Platycladi 5-20 part, Radix Codonopsis 15-20 part.
In the embodiment that the present invention one is concrete, the Chinese medicine composition of described a kind of prevention and therapy chronic nephritis is made up of the crude drug of following weight portion: Rhizoma Imperatae 15-25 part, Poria 20-30 part, Radix Notoginseng 15-25 part, Rhizoma Cyperi 10-20 part, kidney tea 20-30 part, Semen Persicae 15-25 part, Herba Hyperici Monogyni 5-15 part, Rhizoma Alismatis 10-25 part, Radix Rehmanniae Preparata 15-20 part, Fructus Ligustri Lucidi 20-35 part, Cacumen Platycladi 15-25 part, Radix Codonopsis 5-15 part.
In the embodiment that the present invention one is concrete, the Chinese medicine composition of described a kind of prevention and therapy chronic nephritis is made up of the crude drug of following weight portion: Rhizoma Imperatae 27 parts, 23 parts, Poria, Radix Notoginseng 16 parts, Rhizoma Cyperi 19 parts, kidney tea 28 parts, 14 parts, Semen Persicae, Herba Hyperici Monogyni 14 parts, Rhizoma Alismatis 20 parts, 17 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 32 parts, Cacumen Platycladi 21 parts, Radix Codonopsis 15 parts.
In the embodiment that the present invention one is concrete, the Chinese medicine composition of described a kind of prevention and therapy chronic nephritis is made up of the crude drug of following weight portion: Rhizoma Imperatae 30 parts, 25 parts, Poria, Radix Notoginseng 15 parts, Rhizoma Cyperi 20 parts, kidney tea 15 parts, 20 parts, Semen Persicae, Herba Hyperici Monogyni 10 parts, Rhizoma Alismatis 20 parts, 15 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 30 parts, Cacumen Platycladi 20 parts, Radix Codonopsis 15 parts.
In the embodiment that the present invention one is concrete, the Chinese medicine composition of described a kind of prevention and therapy chronic nephritis is made up of the crude drug of following weight portion: Rhizoma Imperatae 20 parts, 15 parts, Poria, Radix Notoginseng 20 parts, Rhizoma Cyperi 15 parts, kidney tea 25 parts, 15 parts, Semen Persicae, Herba Hyperici Monogyni 18 parts, Rhizoma Alismatis 23 parts, 12 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 26 parts, Cacumen Platycladi 17 parts, Radix Codonopsis 13 parts.
The present invention provides a kind of preparation method of Chinese medicine composition of prevention and therapy chronic nephritis on the other hand, and it is characterized in that, the preparation method of this traditional Chinese medicine composition comprises the following steps:
(1) Poria, Radix Notoginseng, kidney tea, Herba Hyperici Monogyni, Fructus Ligustri Lucidi, Cacumen Platycladi add soak by water 2-3 time accounting for gross weight 8-15 times amount, each 1.5-2 hour, collecting decoction, add the aqueous solution that step (1) obtains again, filter, relative density when filtrate is concentrated into 80 DEG C is the extractum (I) of 1.15-1.25;
(2) Rhizoma Imperatae, Rhizoma Cyperi, Semen Persicae, Rhizoma Alismatis, Radix Rehmanniae Preparata, Radix Codonopsis are added account for gross weight 8-15 times amount 85% alcoholic solution in extract 2-3 time, each 2-3 hour, filter, merging filtrate, placement is spent the night, reclaim ethanol, relative density when filtrate being concentrated into 60 DEG C is the extractum (II) of 1.15-1.25;
(3) in step (1), the mixing of (2) gained extractum, dry, stir, to obtain final product.
In a concrete embodiment of the present invention, wherein add the soak by water 3 times accounting for gross weight 10 times amount in step (1), each 1.5 hours; Account in step (2) in the alcoholic solution of 85% of gross weight 10 times amount and extract 2 times, each 3 hours.
The Chinese medicine composition of prevention and therapy chronic nephritis of the present invention, also can prepare according to the conventional method of the field of Chinese medicines, comprises soak by water, by each crude drug pulverize etc.The conventional method of Chinese medicine preparation can be adopted to be prepared into any traditional oral preparation.Described oral formulations is capsule, pill, powder, tablet, granule, decoction, soft capsule.
Chinese medicine composition of the present invention, based on the dialectical prescription of tcm theory, this Chinese medicine composition has effect of diuretic circulation of qi promoting, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, expelling wind and removing dampness, for prevention and therapy chronic nephritis, has no side effect, Be very effective.
Detailed description of the invention
Embodiment 1:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 27g, Poria 23g, Radix Notoginseng 16g, Rhizoma Cyperi 19g, kidney tea 28g, Semen Persicae 14g, Herba Hyperici Monogyni 14g, Rhizoma Alismatis 20g, Radix Rehmanniae Preparata 17g, Fructus Ligustri Lucidi 32g, Cacumen Platycladi 21g, Radix Codonopsis 15g;
Each crude drug is dry at 45 DEG C, be cooled to room temperature, pulverize state, and mix homogeneously, load snap fit capsule, to obtain final product.
Embodiment 2:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 27g, Poria 23g, Radix Notoginseng 16g, Rhizoma Cyperi 19g, kidney tea 28g, Semen Persicae 14g, Herba Hyperici Monogyni 14g, Rhizoma Alismatis 20g, Radix Rehmanniae Preparata 17g, Fructus Ligustri Lucidi 32g, Cacumen Platycladi 21g, Radix Codonopsis 15g;
Take above-mentioned Chinese medicine composition by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 3:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 27g, Poria 23g, Radix Notoginseng 16g, Rhizoma Cyperi 19g, kidney tea 28g, Semen Persicae 14g, Herba Hyperici Monogyni 14g, Rhizoma Alismatis 20g, Radix Rehmanniae Preparata 17g, Fructus Ligustri Lucidi 32g, Cacumen Platycladi 21g, Radix Codonopsis 15g;
Preparation method comprises the following steps:
(1) Poria, Radix Notoginseng, kidney tea, Herba Hyperici Monogyni, Fructus Ligustri Lucidi, Cacumen Platycladi add the soak by water 3 times accounting for gross weight 10 times amount, each 2 hours, collecting decoction, add the aqueous solution that step (1) obtains again, filter, relative density when filtrate is concentrated into 80 DEG C is the extractum (I) of 1.15-1.25;
(2) Rhizoma Imperatae, Rhizoma Cyperi, Semen Persicae, Rhizoma Alismatis, Radix Rehmanniae Preparata, Radix Codonopsis are added account for gross weight 10 times amount 85% alcoholic solution in extract 3 times, each 2 hours, filter, merging filtrate, placement is spent the night, reclaim ethanol, relative density when filtrate being concentrated into 60 DEG C is the extractum (II) of 1.15-1.25;
(3) in step (1), the mixing of (2) gained extractum, dry, stir, incapsulate and get final product.
Embodiment 4:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 30g, Poria 25g, Radix Notoginseng 15g, Rhizoma Cyperi 20g, kidney tea 15g, Semen Persicae 20g, Herba Hyperici Monogyni 10g, Rhizoma Alismatis 20g, Radix Rehmanniae Preparata 15g, Fructus Ligustri Lucidi 30g, Cacumen Platycladi 20g, Radix Codonopsis 15g;
Take above-mentioned Chinese medicine composition by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Embodiment 5:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 20g, Poria 15g, Radix Notoginseng 20g, Rhizoma Cyperi 15g, kidney tea 25g, Semen Persicae 15g, Herba Hyperici Monogyni 18g, Rhizoma Alismatis 23g, Radix Rehmanniae Preparata 12g, Fructus Ligustri Lucidi 26g, Cacumen Platycladi 17g, Radix Codonopsis 13g;
Take above-mentioned Chinese medicine composition by formula ratio, be added to the water, boil, slow fire boiling 30 minutes, filter, filtering residue adds water again, slow fire boiling 30 minutes, merge twice medicinal liquid, to obtain final product.
Comparative example 1:
A Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 27g, Poria 23g, Radix Notoginseng 16g, Rhizoma Cyperi 19g, kidney tea 28g, Semen Persicae 14g, Herba Hyperici Monogyni 14g, Rhizoma Alismatis 20g, Radix Rehmanniae Preparata 17g, Fructus Ligustri Lucidi 32g;
Each crude drug is dry at 45 DEG C, be cooled to room temperature, pulverize state, and mix homogeneously, load snap fit capsule, to obtain final product.
Embodiment 6: Chinese medicine composition of the present invention is to the preventive and therapeutic effect to rat Passive-Heymann Nephritis model
Passive-type Heymarm nephritis is the classical model of research mankind membranous nephropathy, take High-grade Proteinuria as marked feature [Chinese Journal of Nephrology .1999.15 (3): 158].Therefore, the present invention Heymann Nephritis Model studies the preventive and therapeutic effect of Chinese medicine composition of the present invention to nephritis.
1, experimental animal
Wistar rat, male, body weight: 175 ~ 200 grams
2, test method
The anti-FX1A serum of 2.1 preparation
1) FX1A antigen is prepared
Normal male Wistar rat, to sterilize after etherization skin, cut off splanchnocoel, with aseptic cold saline lavation kidney, then be separated renal cortex to weigh, appropriate normal saline is added after cortex is fully ground to form homogenate, filter with 80 orders, 100 orders and 220 eye mesh screens successively, collect last filtrate, filtrate is centrifugal with 1600r/min20min, get supernatant, repeated centrifugation once, gets supernatant, more centrifugal with 10000r/min30min after abandon supernatant, precipitate distilled water is washed 3 times, and gained precipitate is FXA1A antigen.
2) anti-FX1A serum is prepared
By the FXA1A antigen of above-mentioned preparation and equal-volume Freund's complete adjuvant fully emulsified after, serum, through subcutaneous inoculation large ear rabbit, is got after immunity 6 times altogether in interval 2 weeks.Measure by immune directional diffusion and indirect immunofluorescence and tire, reach 1: 32 and 1: 2000 respectively for qualified.Carotid artery gets blood, separation of serum, and it is anti-FX1A serum, and-20 DEG C for subsequent use, uses front deactivation.
2.2, the foundation of Passive-Heymann Nephritis model model and animal grouping
Extracting male Wistar rat 75, their 24h urine protein is all less than 10mg.Stochastic averagina is divided into 5 groups: positive controls, Chinese medicine composition group of the present invention, comparative example 1 Chinese medicine composition group, model control group and blank group.The disposable tail vein injection saline 5ml/kg of blank group; All the other are respectively organized the disposable tail vein injection of rat anti-FX1A serum 5ml/kg and carry out modeling, per os gastric infusion every day (dosage calculates with every kg body weight respectively) was played the same day in modeling, totally 4 weeks, dosage is respectively positive controls (dexamethasone, 0.1mg/kg/d); Chinese medicine composition group (30g/kg/d) of the present invention; Comparative example 1 Chinese medicine composition group (30mg/kg/d); Sodium carboxymethyl cellulose (CMCNa) the suspension 5mg/kg/d of model group contrast and every the rat oral perfusion 0.5% every day of blank group.(capsule 's content prepared by the embodiment of the present invention 1, the capsule 's content of comparative example 1 preparation and dexamethasone use the sodium carboxymethyl cellulose of 0.5% (CMCNa) mixture to make respective concentration respectively)
2.3, observation index
Urine protein quantitation adopts BCA (bicinchoninincacid) method, and 5 groups all start to put into metabolic cage respectively in modeling the 2nd and the 4th week weekend, collects 24h urine.Measurement data represents with mean ± standard deviation (x ± SD), and each group compares with model group respectively, adopts bilateral two sample t-test to carry out statistical analysis.
Table 1 Chinese medicine composition of the present invention is on the impact of rat urine protein content
| Group | 14th day urine albumen amount (mg/24h) | 28th day urine albumen amount (mg/24h) |
| Blank group | 4.7±1.5** | 4.8±1.3 ** |
| Model control group | 42.3±24.5 | 46.8±24.3 |
| Positive controls | 13.2±3.7** | 15.3±4.5 ** |
| Chinese medicine composition group of the present invention | 13.6±4.8** | 16.9±4.2 ** |
| Comparative example 1 Chinese medicine composition group | 18.8±5.2** | 20.6±4.6 ** |
Compare with model group:
*p < 0.01
From table 1, Chinese medicine composition group urine albumen amount of the present invention is starkly lower than model group (P < 0.05), close to positive controls, illustrate that Chinese medicine composition of the present invention has significant curative effect to Passive-Heymann Nephritis model, and each component of Chinese medicine of the present invention is worked in coordination with mutually, omitting wherein two kinds of component effects can decline.
Embodiment 7 clinical trial
For the curative effect of proved invention traditional Chinese medicine composition for treating chronic nephritis, the Chinese medicine adopting embodiment 2 to prepare has carried out following clinical and experimental study
1, physical data:
100 examples are met this patient of diagnostic criteria, be divided into treatment group 50 example and matched group 50 example according to randomization, two groups of physical data, through statistical procedures no significant difference (P > 0.05), have comparability.The primary glomerulopathy diagnostic criteria that chronic nephritis diagnostic criteria is formulated with reference to the nephropathy special interest group discussion of in June, 1992 " CHINESE JOURNAL OF INTERNAL MEDICINE " editorial board.Allly meet chronic nephritis diagnostic criteria, the age, normal renal function person all included the object of observation in 15-65 year.Get rid of pregnant and lactating women, merge disease and the allergic constitution persons such as severe cardiac, brain, liver and hemopoietic system.
2, Therapeutic Method
Matched group: adopt prednisone 1mg/kgd, every day is once oral, is used in conjunction 8 weeks, gradually decrement, weekly decrement 10% to maintenance dose.There is the infected, infection control, but avoid using renal damage Chinese medicine composition; There is hypertension patient, select ACEI preparation or calcium antagonist and high quality protein diet etc.
Treatment group: the Chinese medicine adding the embodiment of the present invention 2 on matched group basis, potion, divided and took for three times every day.
Two groups was all a course for the treatment of with two months.Twenty-four-hour urine protein quantification, renal function and main clinic symptoms situation of change before and after main detection two groups treatment.
3, curative effect judging standard
The curative effect determinate standard that criterion of therapeutical effect is formulated with reference to the nephropathy special interest group discussion of " CHINESE JOURNAL OF INTERNAL MEDICINE " editorial board.
Complete incidence graph: clinical symptom disappearance, urine protein is turned out cloudy, urine protein quantitation < 0.28g/d, normal renal function;
Remarkable alleviation: clinical symptom disappearance or alleviate, urine protein quantitation 0.2-1.0g/d, or quantitatively reduce >=50%, stable renal function;
Partial rcsponse: clinical symptom relief, urine protein < 3g/d or > 3g/d, but quantitatively reduce >=50%, stable renal function;
Invalid: symptom is without improvement or increase the weight of, and urine protein does not reduce, serum creatinine increases >=1 times.
4, result
Treat after two months:
Treatment group: complete incidence graph 25 example, significantly alleviates 15 examples, partial rcsponse 7 example, invalid 3 examples;
Matched group: complete incidence graph 13 example, significantly alleviates 10 examples, partial rcsponse 17 example, invalid 10 examples.
5, before and after two groups of treatments, twenty-four-hour urine protein quantification compares (see table 2)
Table 2 Chinese medicine composition of the present invention is on the impact of urine albumen amount
With this group before treatment
*p < 0.05
Shown by the data of table 2, Chinese medicine composition of the present invention can significantly reduce Urinary protein content.
Claims (8)
1. a Chinese medicine composition for prevention and therapy chronic nephritis, is made up of the crude drug of following weight portion: Rhizoma Imperatae 15-35 part, Poria 10-30 part, Radix Notoginseng 10-25 part, Rhizoma Cyperi 10-25 part, kidney tea 10-30 part, Semen Persicae 10-25 part, Herba Hyperici Monogyni 5-20 part, Rhizoma Alismatis 5-25 part, Radix Rehmanniae Preparata 10-20 part, Fructus Ligustri Lucidi 10-35 part, Cacumen Platycladi 5-25 part, Radix Codonopsis 5-20 part.
2. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 1, is made up of the crude drug of following weight portion: Rhizoma Imperatae 20-35 part, Poria 10-25 part, Radix Notoginseng 15-25 part, Rhizoma Cyperi 10-20 part, kidney tea 10-25 part, Semen Persicae 15-25 part, Herba Hyperici Monogyni 15-20 part, Rhizoma Alismatis 10-25 part, Radix Rehmanniae Preparata 10-15 part, Fructus Ligustri Lucidi 10-20 part, Cacumen Platycladi 5-20 part, Radix Codonopsis 15-20 part.
3. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 1, is made up of the crude drug of following weight portion: Rhizoma Imperatae 15-25 part, Poria 20-30 part, Radix Notoginseng 15-25 part, Rhizoma Cyperi 10-20 part, kidney tea 20-30 part, Semen Persicae 15-25 part, Herba Hyperici Monogyni 5-15 part, Rhizoma Alismatis 10-25 part, Radix Rehmanniae Preparata 15-20 part, Fructus Ligustri Lucidi 20-35 part, Cacumen Platycladi 15-25 part, Radix Codonopsis 5-15 part.
4. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 1, is made up of the crude drug of following weight portion: Rhizoma Imperatae 27 parts, 23 parts, Poria, Radix Notoginseng 16 parts, Rhizoma Cyperi 19 parts, kidney tea 28 parts, 14 parts, Semen Persicae, Herba Hyperici Monogyni 14 parts, Rhizoma Alismatis 20 parts, 17 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 32 parts, Cacumen Platycladi 21 parts, Radix Codonopsis 15 parts.
5. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 1, is made up of the crude drug of following weight portion: Rhizoma Imperatae 30 parts, 25 parts, Poria, Radix Notoginseng 15 parts, Rhizoma Cyperi 20 parts, kidney tea 15 parts, 20 parts, Semen Persicae, Herba Hyperici Monogyni 10 parts, Rhizoma Alismatis 20 parts, 15 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 30 parts, Cacumen Platycladi 20 parts, Radix Codonopsis 15 parts.
6. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 1, is made up of the crude drug of following weight portion: Rhizoma Imperatae 20 parts, 15 parts, Poria, Radix Notoginseng 20 parts, Rhizoma Cyperi 15 parts, kidney tea 25 parts, 15 parts, Semen Persicae, Herba Hyperici Monogyni 18 parts, Rhizoma Alismatis 23 parts, 12 parts, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi 26 parts, Cacumen Platycladi 17 parts, Radix Codonopsis 13 parts.
7. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis described in claim 1-6, is characterized in that, adopts the conventional method of Chinese medicine preparation to be prepared into any traditional oral preparation.
8. the Chinese medicine composition of a kind of prevention and therapy chronic nephritis according to claim 7, is characterized in that, described oral formulations is capsule, pill, powder, tablet, granule, decoction, soft capsule.
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| CN107115477A (en) * | 2017-06-13 | 2017-09-01 | 青岛市中心医院 | A kind of Chinese medicine composition for preventing and treating chronic nephritis |
| CN107213262A (en) * | 2017-06-13 | 2017-09-29 | 青岛市中心医院 | A kind of medicine for preventing and treating CGN |
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| CN104435828A (en) * | 2014-11-19 | 2015-03-25 | 商秋伟 | Traditional Chinese medicine composition for treating chronic nephritis |
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|---|---|---|---|---|
| CN107115477A (en) * | 2017-06-13 | 2017-09-01 | 青岛市中心医院 | A kind of Chinese medicine composition for preventing and treating chronic nephritis |
| CN107213262A (en) * | 2017-06-13 | 2017-09-29 | 青岛市中心医院 | A kind of medicine for preventing and treating CGN |
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Application publication date: 20160511 |