CN105536156A - Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof - Google Patents
Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof Download PDFInfo
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Abstract
The invention discloses an ultrasonic brain stimulation or regulation and control method based on a large scale area array element and an apparatus thereof. The method comprises the following steps of step1, establishing a head-portion three-dimensional digital model; step2, arranging a virtual sound source at a brain position which needs to be stimulated or regulated and controlled and using the a virtual sound source to emit ultrasonic waves to peripheries; step3, based on the head-portion three-dimensional digital model, carrying out sound field simulation, simulating acoustic parameters of the ultrasonic waves which arrive at an array element position after passing through brain tissues, a skull and an ultrasonic coupling device and are emitted by the virtual sound source, and carrying out emulation to acquire a voltage signal of an ultrasonic transducer after piezoelectric conversion; step4, according to the acquired acoustic parameters and the voltage signal, carrying out time reversal, exerting a voltage corresponding to the voltage signal on the array element, emitting the ultrasonic wave, realizing focusing of the ultrasonic wave which passes through the skull and is at the virtual sound source position in the brain, and carrying out ultrasonic brain stimulation or regulation and control.
Description
Technical field
The invention belongs to medical field, espespecially a kind of ultrasonic brain stimulation based on extensive face array element or regulate and control method and device.
Background technology
Functional brain disease (parkinson disease, Alzheimer, epilepsy, depression etc.) has become global significant medical problem and heavy burden on society.Still unclear to the exact mechanism of functional brain disease at present, and lack effective remedy measures, remain the significant medical challenge that the whole world faces.The cerebral cortex reporting dog under electricity irritation continue Germany scientist in 1870 can cause specific Tenseness after more than 100 year in, the technology such as electricity, magnetic, light combine with neuroscience nerve stimulation and control techniques such as creating deep brain stimulation, Neural stem cell, photogene regulation and control.The appearance of these neuromodulation technology greatly facilitates the fast development of neurosciences such as also opening emotion, memory, cognition and brain science research and disease of brain intervention and treatment technology and instrument application.Then, the neuromodulation instruments such as electrode stimulating and light hereditism owing to there being wound to brain, limit its disease of brain research in application.Neural stem cell to shallow cortex effect, and can only lack spatial accuracy.Hyperacoustic unique mechanical ripple physical attribute and mechanics effect thereof control the new discovery of neurocyte electrical activity, become the new tool realizing a kind of great potential that noinvasive nerve stimulation and disease of brain are studied and treated.
The technology that nerve stimulation and loop regulate and control and instrument promote the important motivity that neuroscience develops.The current goal of nervous system stimulating technology regulates neuron activity by sending exogenous energy to complete loop, thus regulate neurological function.The technology such as electricity, magnetic, light combine with neuroscience nerve stimulation and control techniques such as creating deep brain stimulation, Neural stem cell, photogene regulation and control.
Electrode deep brain stimulation (DeepBrainStimulation, DBS) be feature nerve nucleus target spot in the brain implanted by electrode, stimulated the abnormal neuron function suppressing target cell by controlled high frequency electric, reach the object of effective prevention and disease therapy.Since being used to the control of trembling first from 1987, the whole world has more than 10 ten thousand patients and implants DBS device, for numerous intractable disease of brain as Parkinson's disease, depression, intractable epilepsy, muscular tension imbalance, intractable pain, obsession etc. provide the effective interference method of one.But, the application of DBS also also exists important limitation: 1 ~ 2 electrode being implanted dark cerebral tissue carries out stimulating for core group clinically by operation of opening cranium is the stimulation causing permanent wound, target spot to change to cerebral tissue and neural circuitry, be difficult to realize more multiple location core group, and whole power supply supply equipment also will be surgically implanted in health.The stimulating electrode applied at the brain of individuality can affect the normal function of body, after DBS electrode uses a period of time, glial cell sheath can be formed at surrounding them, not only affect the efficiency of electrode, also can affect the normal function of body, and, when applying electricity irritation, the electricity irritation applied always causes irritability to react, only when stimulating inhibition core group, just can cause inhibitory reaction, these shortcomings also limit the application of electrical stimulation technology in regulation and control neural circuitry.
Transcranial magnetic stimulation (TranscranialMagneticStimulation, TMS) technology is noninvasive treatment technology, instantaneous, the high volt pulses generation one that it is produced by the magnetic coil be positioned on scalp is perpendicular to the territory, magnetic field of coil plane, act on cerebral tissue and produce faradic current, make neuronal depolarization and produce Evoked ptential.This technology may be used for evaluating Electrophysiology pathway, attempts the neurological rehabilitation treatment being used for the diseases such as depression, epilepsy, apoplexy, schizophrenia, infantile autism.But, TMS technology exist the degree of depth that stimulates not, cannot focus on, stimulate the low and stimulated zone of resolution to be difficult to bottlenecks such as determining.
The nearly emerging light genetics technology (Optogenetics) grown up during the last ten years, achieve at a certain microcircuit of cellular level selective regulation, namely by giving the laser realization of different wave length to the irritability of a certain loop or inhibition regulation and control, the development of neuroscience has effectively been promoted.But, light genetics technology be by give carry out exciting light sensitive pathway with the laser of different wave length, because biological tissue seriously to limit the propagation distance (only having some millimeters) of light for the strong absorption of light, therefore need to insert optical fiber and fibre-optic catheter in the corresponding brain district of patient or tested animal, this is inevitably damaged portion brain district when operating, thus causes some physiological function neural to be lost.
Neururgic method is regulated to comprise intrusion and non-intruding technology.But the multiple such as DBS in these technology and light genetics technology need the surgical graft of stimulating electrode, it is intrusion, expensive and even dangerous process.Such as, the surgical graft of stimulating electrode adds secondary medical-risk and such as infects.And although TMS is non-intrusion type, exist stimulate the degree of depth not, cannot focus on, stimulate the low and stimulated zone of resolution to be difficult to bottlenecks such as determining, dark brain stimulation cannot be applied to.
Ultrasonic as a kind of mechanical wave, be vibrated by object (sound source) to produce, and cause it to propagate by compression and expansion medium, medical ultrasonic typically refers to the sound wave of frequency in 20kHz to 10MHz interval.The ultrasonic general property except having ripple, also has an important feature, and its decay in the tissue such as water, muscle is very little, can arrive at darker tissue.Medical ultrasound and tissue interact, mainly apply the Basic Physical Properties of sound wave and matter interaction, have the three large acoustic effects such as fluctuation effect, mechanics effect and heat effect, these effects have important application or great potentiality in biomedicine.Traditional is ultrasonic based on fluctuation effect and heat effect, has developed into and has had image-forming diagnose and the large basic function of thermal ablation therapy two.Fluctuation effect can be used for B ultrasonic, color ultrasound, radiography etc. in the clinical ultra sonic imaging diagnostic techniques with very extensive use; Heat effect can be used for heating ablation and the nerve nucleus damage treatment of tumor, such as high intensity focused ultrasound (HIFU).
The advantage of ultrasonic nerve stimulation and regulation and control is its non-intruding character.The ultrasonic up-to-date scientific evidence of neuromodulation in molecule, cell, animal and human's brain level demonstrate effectively ultrasonic can through people skull noinvasive, effectively regulate synaptic plasticity, neuron regulate and control and brain district, deep nerve nucleus.
Be called that TCD,transcranial Doppler stimulates in the patent application of the device and method (application number CN201210576849.4) repairing cranial nerve function in name, it discloses a kind of TCD,transcranial Doppler and stimulate the device and method repairing cranial nerve function, this device comprises function signal generator, power amplifier and ultrasonic transducer, wherein, after this function signal generator produces the stimulus signal needed for stimulating, the high-voltage pulse signal needed for this ultrasonic transducer is amplified to by this power amplifier, then obtain ultrasound stimulation signal by this ultrasonic transducer, to stimulate cerebral tissue, pass through the present invention, low-power can be realized, high-resolution, noninvasive CO2 laser weld therapeutic purposes.
Being called that use is ultrasonic for regulating in the patent application of method and apparatus (application number CN201510378861.8) of cytoactive in name, it discloses the method and apparatus of one or more activities for regulating living cells (such as finding in people, animal, plant, insecticide, microorganism and other organisms or derivative cell).Method of the present invention comprises ultrasound application (such as low-intensity low frequency ultrasound) to living cells to affect the application of cell and adjustment cytoactive.The inventive system comprises and produce one or more assemblies hyperacoustic, such as ultrasonic transmitter, transducer or piezoelectric transducer, composite transducer, CMUT and the assembly that can be set to list or multi-transducer or be arranged in array structure.Ultrasound wave can be any shape, and can be focusing or unfocused.
Be called in name and regulate in the equipment of cerebral activity and the patent application of method (application number: CN201080056295.4), which provide the equipment and method that regulate for brain.This equipment comprises main body and the parts for activating brain.Such parts comprise ultrasonic transducer.This equipment is used for ultrasound wave being supplied to the brain structure had in the object of this equipment, so as to perform the traumatic cerebral lesion for the treatment of, affect ability of posture control, affect Vigilance, attention and vigilance, the method that Memory control, change cerebral blood vessel hemodynamics is provided, makes the minimum and strengthening behavior action of pressure.
In above-mentioned three sections of published patent formula, have the following disadvantages:
The scheme of first section of patent employs the ultrasonic transducer of single array element.Although, the ultrasonic transducer this ultrasonic transducer being equipped with different-diameter collimator or adopting self-focusing is proposed in its claims.But due to skull heterogeneity with to ultrasonic strong scattering, no matter be adopt collimator, or self-focusing ultrasonic transducer, ultrasound wave is difficult to control by the propagation path after skull, is therefore difficult to realize precise positioning.
There is following shortcoming in second section of patent: although propose ultrasonic module in 1 claims can comprise 1 to 1000 array element, the arrangement for array element does not provide the arrangement mode of optimization; Although propose described ultrasound transducer element in 2 claims to use analog or digital drive waveform, stimulus waveform is made to contain single or many supersonic frequencies, but do not have to propose to take personalized driving parameter (as voltage, time delay) to the element in ultrasound transducer array, to overcome because skull heterogeneity is to ultrasonic strong scattering, thus precisely focus on through producing at dark brain after skull; Although 3 propose ultrasonic module in its claims can comprise as many as 1000 array elements, but in some application scenario, may need to use more massive array arrangement (>1000), to produce more accurate space-focusing.
The equipment of the 3rd section of patent proposition comprises main body and the parts for activating brain, ultrasound wave is supplied to the brain structure had in the object of this equipment, to regulate cerebral activity.When adjustment cerebral activity, need to stimulate different position multiple in brain, and the program does not illustrate by supersonic array and the accurate control to supersonic array, realizes at the accurate multiple spot stimulating method of the three-dimensional of dark brain.
Summary of the invention
For the deficiency that prior art exists, the present invention proposes a kind of ultrasonic brain stimulation based on extensive face array element and regulation device and method.This device comprises extensive face array ultrasonic wave transducer, ultrasonic wave controller, ultrasonic coupling device etc.The method controls ultrasound transducer array by ultrasonic wave controller to launch ultrasound wave, through acoustical coupling device and skull, precisely focuses on, carry out Sound stimulat or regulation and control in one or more positions in brain district, deep.
For achieving the above object, the present invention proposes a kind of ultrasonic brain stimulation based on extensive face array element or regulate and control method, the method comprises: step 1, sets up head three-dimensional digital model; Step 2, needs the position stimulating or regulate and control to arrange virtual sound source at brain, and utilizes this virtual sound source to launch ultrasound wave to surrounding; Step 3, sound field emulation is carried out based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion; Step 4, according to the described parameters,acoustic obtained and voltage signal, by time reversal, applies the voltage of corresponding described voltage signal, launches ultrasound wave to array element, realize ultrasound wave and focus on through the virtual sound source place of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
Further, in step 1, the method comprises: obtain the head construction information and the physical message that comprise skull and brain tissue, set up head three-dimensional digital model according to head construction information and physical message.
Further, in step 1, the method comprises: utilize computed tomography or nuclear magnetic resonance to carry out 3-D scanning to head, obtains the head construction information and the physical message that comprise skull and brain tissue.
Further, the physical message of described head comprises: density, acoustic attenuation.
Further, described parameters,acoustic comprises: the sound intensity, acoustic pressure, ultrasound wave time to go.
For achieving the above object, the invention allows for a kind of ultrasonic brain stimulation based on extensive face array element or regulation device, this device comprises: ultrasonic generator, ultrasonic control device, ultrasonic coupling apparatus; Wherein, ultrasonic generator, comprises transducer array element, for transmitting and receiving ultrasound wave; Ultrasonic coupling apparatus, for the ultrasonic delivery head launched by described ultrasonic generator; Ultrasonic control device, comprising: model building module, for setting up head three-dimensional digital model; Emulation module, for needing the position stimulating or regulate and control to arrange virtual sound source at brain, and utilize this virtual sound source to launch ultrasound wave to surrounding, and carry out sound field emulation based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during transducer element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion; Control module, for according to obtain described parameters,acoustic and voltage signal, by time reversal, control the voltage described transducer array element being applied to corresponding described voltage signal, described ultrasonic generator is made to launch ultrasound wave, realize ultrasound wave to focus on through the virtual sound source place of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
Further, this device comprises: water of radiation device for cooling, for dispelling the heat to described ultrasonic generator.
Further, described model building module, also for obtaining the head construction information and physical message that comprise skull and brain tissue, sets up head three-dimensional digital model according to head construction information and physical message.
Further, described model building module, also for utilizing computed tomography or nuclear magnetic resonance to carry out 3-D scanning to head, obtains the head construction information and the physical message that comprise skull and brain tissue.
Further, the physical message of described head comprises: density, acoustic attenuation.
Further, described parameters,acoustic comprises: the sound intensity, acoustic pressure, ultrasound wave time to go.
The ultrasonic brain stimulation based on extensive face array element that the present invention proposes or regulate and control method and device can realize precisely focusing on by multiple spot in brain, realize single-point or multiple spot dynamic ultrasound stimulates or regulation and control.
Accompanying drawing explanation
Accompanying drawing described herein is used to provide a further understanding of the present invention, forms a application's part, does not form limitation of the invention.In the accompanying drawings:
Fig. 1 is the ultrasonic brain stimulation based on extensive face array element or the regulate and control method flow chart of one embodiment of the invention.
Fig. 2 is the ultrasonic brain stimulation based on extensive face array element or the regulation device structural representation of one embodiment of the invention.
Fig. 3 is the structural representation of the ultrasonic control device of one embodiment of the invention.
Fig. 4 A is 1024 array element two-dimensional surface array arrangement situation schematic diagrams of the present invention one specific embodiment.
Fig. 4 B is the sound field focusing situation schematic diagram that the two-dimensional array of the present invention one specific embodiment is listed in different depth.
Fig. 5 A is the simulation result of single focal pressure field in the acoustic radiation field of force of the four sides array ultrasound transducer of the present invention one specific embodiment.
Fig. 5 B is the simulation result of the four focal pressure fields in the acoustic radiation field of force of the four sides array ultrasound transducer of the present invention one specific embodiment.
Fig. 6 A is that the arcuate array ultrasonic transducer of the present invention one specific embodiment is across the direct focusing results schematic diagram of cranium.
Fig. 6 B is that the arcuate array ultrasonic transducer time reversal of the present invention one specific embodiment is across cranium focusing results schematic diagram.
Fig. 7 A is the phase-control focusing result schematic diagram of four sides battle array across cranium Multi-point focusing of the present invention one specific embodiment.
Fig. 7 B is the time reversal focusing results schematic diagram of four sides battle array across cranium Multi-point focusing of the present invention one specific embodiment.
Detailed description of the invention
Below coordinating diagram and preferred embodiment of the present invention, setting forth the technological means that the present invention takes for reaching predetermined goal of the invention further.
Fig. 1 is the ultrasonic brain stimulation based on extensive face array element or the regulate and control method flow chart of one embodiment of the invention.As shown in Figure 1, the method comprises:
Step 1, sets up head three-dimensional digital model.
Step 2, needs the one or more positions stimulating or regulate and control to arrange virtual sound source at brain, and utilizes this virtual sound source to launch ultrasound wave to surrounding; This step is that the virtual sound source of this one or more position of hypothesis launches ultrasound wave to surrounding.
Step 3, sound field emulation is carried out based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion; Wherein, the parameters,acoustic of head can comprise: the sound intensity, acoustic pressure, ultrasound wave time to go.
Step 4, according to the described parameters,acoustic obtained and voltage signal, by time reversal, array element is applied to the voltage of corresponding described voltage signal, launch ultrasound wave, realize ultrasound wave and focus on through one or more virtual sound source places of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
Further, in step 1, the method comprises: obtain the head construction information and the physical message that comprise skull and brain tissue, set up head three-dimensional digital model according to head construction information and physical message.Wherein, the physical message of head can comprise: density, acoustic attenuation etc.
Further, in step 1, computed tomography (CT) or nuclear magnetic resonance (MRI) or other three-D imaging method can be utilized to carry out 3-D scanning to head, obtain the head construction information and the physical message that comprise skull and brain tissue.
Further, in step 3, sound field emulation refers to based on head three-dimensional digital model, utilize ultrasound wave that numerical simulation software simulation virtual sound source is launched after brain tissue, skull, ultrasonic coupling apparatus, arrive the element position parameters,acoustic that is, and and then simulate the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion.Numerical simulation software package draws together such as Finite Difference-Time Domain component software (FDTD), COMSOL, PZFlex or other software.
Based on foregoing invention design, additionally provide a kind of ultrasonic brain stimulation based on extensive face array element or regulation device in the embodiment of the present invention, as described in the following examples.The principle of dealing with problems due to this device is similar to the above-mentioned ultrasonic brain stimulation based on extensive face array element or regulate and control method, and therefore the enforcement of this device see the enforcement of said method, can repeat part and repeat no more.Following used, term " unit " or " module " can realize the software of predetermined function and/or the combination of hardware.Although the device described by following examples preferably realizes with software, hardware, or the realization of the combination of software and hardware also may and conceived.
Fig. 2 is the ultrasonic brain stimulation based on extensive face array element or the regulation device structural representation of one embodiment of the invention.As shown in Figure 2, this device comprises: ultrasonic generator 1, ultrasonic coupling apparatus 2, ultrasonic control device 3; In addition, this device can also comprise water of radiation device for cooling 4.
Wherein, ultrasonic generator 1, comprises transducer array element, for transmitting and receiving ultrasound wave.
Ultrasonic coupling apparatus 2, for the ultrasonic delivery head launched by described ultrasonic generator.
Fig. 3 is the structural representation of the ultrasonic control device of one embodiment of the invention.As shown in Figure 3, ultrasonic control device 3 comprises:
Model building module 31, for setting up head three-dimensional digital model;
Emulation module 32, for needing the position stimulating or regulate and control to arrange virtual sound source at brain, and utilize this virtual sound source to launch ultrasound wave to surrounding, and carry out sound field emulation based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during transducer element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion;
Control module 33, for according to obtain described parameters,acoustic and voltage signal, by time reversal, control the voltage described transducer array element being applied to corresponding described voltage signal, described ultrasonic generator is made to launch ultrasound wave, realize ultrasound wave to focus on through the virtual sound source place of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
Further, water of radiation device for cooling 4, for dispelling the heat to described ultrasonic generator.
In the present embodiment, control instruction can be transferred to ultrasonic control device 3 by computer by user, and ultrasonic control device 3 receives instruction, controls ultrasonic generator 1.Because have space between ultrasonic generator 1 (ultrasonic probe) and head, air will be had, and the aerial decay of ultrasound wave is very large, so need to arrange ultrasonic coupling apparatus 3, reduce decay, the ultrasonic energy that ultrasonic generator 1 sends is coupled to head.Due to a large amount of heat can be produced time ultrasonic generator 1 works, water of radiation device for cooling 4 is therefore needed to dispel the heat.
In the present embodiment, model building module 31, also for obtaining the head construction information and physical message that comprise skull and brain tissue, sets up head three-dimensional digital model according to head construction information and physical message.
In the present embodiment, model building module 31, also for utilizing computed tomography or nuclear magnetic resonance to carry out 3-D scanning to head, obtains the head construction information and the physical message that comprise skull and brain tissue.
In the present embodiment, ultrasonic generator 1 can comprise for generating hyperacoustic one or more parts, can be such as ultrasonic transmitter, transducer, piezoelectric transducer, piezoelectric polymer transducer, composite transducer, gaseous substrate piezoelectric transducer, CMUT (capacitance type micromachined ultrasonic transducer), PMUT (piezoelectric micromachined ultrasonic transducer).
Transducer array element in ultrasonic generator 1 is arranged with the form of array, can be planar array, sphere, cambered surface or other are applicable to other structures of head or form is arranged.
The parts transmitted and receive data for controlling ultrasound wave array element can also be comprised in ultrasonic control device 3, ultrasound wave array element transmit block, control waveform that one or more array element sends, power and time delay, control multiple array element collaborative work and launch ultrasound wave, described ultrasound wave array element receiving-member, controls array element and receives echo.
The ultrasonic brain stimulation based on extensive face array element that the present invention proposes or regulate and control method and device, compared with first section of patent formula in background technology.First section of patent formula uses the ultrasonic transducer of single array element, and due to skull heterogeneity with to ultrasonic strong scattering, ultrasound wave is difficult to control by the propagation path after skull, is therefore difficult to realize precise positioning.The present invention is based on time reversal method, utilizes ultrasonic controller to control extensive face array ultrasound transducer, can realize precisely focusing on by multiple spot in brain, realize single-point or multiple spot, dynamic ultrasound stimulation and regulation and control.
Compared with second section of patent formula in background technology, second section of patent formula proposes the ultrasonic transducer of employing 1 to 1000 array element, concrete array element arrangement mode is not proposed, do not propose concrete transducer array element type of drive, 1000 array elements also not necessarily enough produce across the accurate focusing in cranium brain.The present invention adopts extensive face array ultrasound transducer (to one ten thousand), based on time reversal method, the each array element of ultrasonic controller to extensive face array ultrasound transducer is utilized to adopt personalized driving parameter (as voltage, time delay), overcome because skull heterogeneity is to ultrasonic strong scattering, implement the accurate focusing of single-point or multiple spot in brain, realize multiple spot, dynamic ultrasound stimulation and regulation and control.
Compared with the 3rd section of patent formula in background technology, the 3rd section of patent formula does not illustrate by supersonic array and the accurate control to supersonic array, realizes at the accurate multiple spot stimulating method of the three-dimensional of dark brain.The present invention controls ultrasound transducer array by ultrasonic control device and launches ultrasound wave, through acoustical coupling device and skull, precisely focuses on, carry out Sound stimulat or regulation and control in one or more positions in brain district, deep.
In order to more clearly explain the above-mentioned ultrasonic brain stimulation based on extensive face array element or regulate and control method and device, be described below in conjunction with several specific embodiment, but it should be noted that this embodiment is only to better the present invention is described, do not form and the present invention is limited improperly.
Embodiment 1: the single point focus of emulation two-dimensional array probe in space, two-dimensional array as shown in Figure 4 A has the square formation of 32 × 32 of 1024 array element compositions.The mid frequency of piezoelectricity array element is 1.5MHz, and array element diameter is 5.0mm, and array element distance is 0.15mm.Fig. 4 B is depicted as the sound field focusing situation that two-dimensional array is listed in different depth.
Embodiment 2: the acoustic radiation force field distribution of emulation four sides array ultrasound transducer, mid frequency is 0.5MHz, and the depth of focus is 100-150mm.The simulation result of single focal pressure field shown in Fig. 5 A, Fig. 5 B is the simulation result of four focal pressure fields.
Embodiment 3: emulation arcuate array ultrasonic transducer carries out the result focused at dark brain through crinial bone.Utilize skull image, treatedly obtain two-dimentional Skull research model, the external diameter of skull is about 300mm, temporarily do not consider layering and the heterogeneity of skull itself, also do not consider shear wave effect in skull, only skull is regarded as even sound wave medium, parameters,acoustic is density 1658kg/m
3, velocity of sound 3360m/s; Temporarily do not consider the cerebral tissue heterogeneity of intracranial, the part except skull is all set to water, and parameters,acoustic is density 1000kg/m
3, velocity of sound 1500m/s.
Fig. 6 A is depicted as arcuate array ultrasonic transducer across the direct focusing results schematic diagram of cranium, and Fig. 6 B is depicted as the time reversal of arcuate array ultrasonic transducer across cranium focusing results schematic diagram, and the cranium of wearing that two figure simulation results show the cambered surface battle array of 512 array elements focuses on.The frequency of piezoelectricity array element is 1MHz, Fig. 6 A is the result that semicircle transducer array directly focuses to geometric center, and Fig. 6 B is that time reversal is across cranium focusing results.Peak sound pressure distribute, all with intracranial maximum sound pressure value for standard has made normalized.The focus that the inverting of contrast SEE time focuses on is less, and energy is more concentrated.
Embodiment 4: the result that emulation four sides array ultrasound transducer focuses on across cranium.Throw in energy from 4 directions, when comparatively throwing in energy from single direction, focus point shape is more regular, and focal spot size is less, energy centralization degree higher (strong gradient fields).Fig. 7 A is depicted as the phase-control focusing result schematic diagram of four sides battle array across cranium Multi-point focusing of the present invention one specific embodiment, Fig. 7 B is depicted as the time reversal focusing results schematic diagram of four sides battle array across cranium Multi-point focusing of the present invention one specific embodiment, and has carried out quantitative contrast.Because the amplitude of each array element transmitted waveform of time reversal is different, get the emission maximum energy of time reversal identical with the emitted energy of phase-control focusing time, normalization is done to the acoustic pressure amplitude at each focus place, and contrasts.The sound pressure amplitude of time reversal method 4 focuses is respectively: 1.00,1.00,0.95,0.83; The sound pressure amplitude of phase-control focusing method 4 focuses is respectively: 0.70,0.18,0.41,0.43.From result, four sides battle array can realize the accurate focusing of multiple spot across cranium time reversal.
The ultrasonic brain stimulation based on extensive face array element that the present invention proposes or regulate and control method and device can realize precisely focusing on by multiple spot in brain, realize single-point or multiple spot dynamic ultrasound stimulates or regulation and control.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; be understood that; the foregoing is only specific embodiments of the invention; the protection domain be not intended to limit the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1., based on ultrasonic brain stimulation or the regulate and control method of extensive face array element, it is characterized in that, the method comprises:
Step 1, sets up head three-dimensional digital model;
Step 2, needs the position stimulating or regulate and control to arrange virtual sound source at brain, and utilizes this virtual sound source to launch ultrasound wave to surrounding;
Step 3, sound field emulation is carried out based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion;
Step 4, according to the described parameters,acoustic obtained and voltage signal, by time reversal, applies the voltage of corresponding described voltage signal, launches ultrasound wave to array element, realize ultrasound wave and focus on through the virtual sound source place of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
2. method according to claim 1, is characterized in that, in step 1, the method comprises:
Obtain the head construction information and the physical message that comprise skull and brain tissue, set up head three-dimensional digital model according to head construction information and physical message.
3. method according to claim 2, is characterized in that, in step 1, the method comprises:
Utilize computed tomography or nuclear magnetic resonance to carry out 3-D scanning to head, obtain the head construction information and the physical message that comprise skull and brain tissue.
4. according to the method in claim 2 or 3, it is characterized in that, the physical message of described head comprises: density, acoustic attenuation.
5. method according to claim 1, is characterized in that, described parameters,acoustic comprises: the sound intensity, acoustic pressure, ultrasound wave time to go.
6. based on ultrasonic brain stimulation or the regulation device of extensive face array element, it is characterized in that, this device comprises: ultrasonic generator, ultrasonic control device, ultrasonic coupling apparatus; Wherein,
Ultrasonic generator, comprises transducer array element, for transmitting and receiving ultrasound wave;
Ultrasonic coupling apparatus, for the ultrasonic delivery head launched by described ultrasonic generator;
Ultrasonic control device, comprising:
Model building module, for setting up head three-dimensional digital model;
Emulation module, for needing the position stimulating or regulate and control to arrange virtual sound source at brain, and utilize this virtual sound source to launch ultrasound wave to surrounding, and carry out sound field emulation based on described head three-dimensional digital model, simulate the ultrasound wave of described virtual sound source transmitting after brain tissue, skull, ultrasonic coupling apparatus, arrive parameters,acoustic during transducer element position, and emulation obtains the voltage signal that ultrasonic transducer obtains after piezoelectricity conversion;
Control module, for according to obtain described parameters,acoustic and voltage signal, by time reversal, control the voltage described transducer array element being applied to corresponding described voltage signal, described ultrasonic generator is made to launch ultrasound wave, realize ultrasound wave to focus on through the virtual sound source place of skull in brain, carry out ultrasonic brain stimulation or regulation and control.
7. device according to claim 6, is characterized in that, this device comprises: water of radiation device for cooling, for dispelling the heat to described ultrasonic generator.
8. device according to claim 6, is characterized in that, described model building module, also for obtaining the head construction information and physical message that comprise skull and brain tissue, sets up head three-dimensional digital model according to head construction information and physical message.
9. device according to claim 6, it is characterized in that, described model building module, also for utilizing computed tomography or nuclear magnetic resonance to carry out 3-D scanning to head, obtains the head construction information and the physical message that comprise skull and brain tissue.
10. device according to claim 8 or claim 9, it is characterized in that, the physical message of described head comprises: density, acoustic attenuation.
11. devices according to claim 6, is characterized in that, described parameters,acoustic comprises: the sound intensity, acoustic pressure, ultrasound wave time to go.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510990909.0A CN105536156A (en) | 2015-12-25 | 2015-12-25 | Ultrasonic brain stimulation or regulation and control method based on large scale area array element and apparatus thereof |
| PCT/CN2015/099509 WO2017107230A1 (en) | 2015-12-25 | 2015-12-29 | Ultrasonic brain stimulation or regulation and control method and apparatus based on large-scale area array element |
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| CN105943031A (en) * | 2016-05-17 | 2016-09-21 | 西安交通大学 | Wearable transcranial ultrasound nerve stimulation and electrophysiological recording combined system and method |
| CN110160517A (en) * | 2019-05-22 | 2019-08-23 | 上海交通大学 | A kind of real-time navigation method and system of ultrasonic transducer |
| WO2019191863A1 (en) * | 2018-04-02 | 2019-10-10 | 中国科学院深圳先进技术研究院 | Ultrasonic imaging system, method, and apparatus |
| CN111938628A (en) * | 2020-09-01 | 2020-11-17 | 天津大学 | Electroencephalogram source signal detection device based on transcranial focused ultrasound stimulation |
| CN112349446A (en) * | 2020-11-03 | 2021-02-09 | 深圳先进技术研究院 | Control method and acoustic tweezers device |
| CN112604191A (en) * | 2020-12-14 | 2021-04-06 | 中国科学院深圳先进技术研究院 | Multi-focus ultrasonic wave generation device and method |
| CN113195052A (en) * | 2018-10-22 | 2021-07-30 | 瓦伦西亚理工大学 | Method for producing lens and ultrasonic device containing lens |
| CN113613708A (en) * | 2019-01-23 | 2021-11-05 | 香港理工大学 | Method of targeted energy delivery on an implantable device using one or more ultrasound transducers |
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| CN112349446A (en) * | 2020-11-03 | 2021-02-09 | 深圳先进技术研究院 | Control method and acoustic tweezers device |
| CN112604191A (en) * | 2020-12-14 | 2021-04-06 | 中国科学院深圳先进技术研究院 | Multi-focus ultrasonic wave generation device and method |
| CN114768126A (en) * | 2022-04-29 | 2022-07-22 | 重庆大学 | Ultrasonic frequency determination method, ultrasonic output method and device and electronic equipment |
| CN114768126B (en) * | 2022-04-29 | 2024-05-03 | 重庆大学 | Ultrasonic frequency determining method, ultrasonic output method and device and electronic equipment |
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