CN105535270A - Medicine composition for treating scapulohumeral periarthritis - Google Patents

Medicine composition for treating scapulohumeral periarthritis Download PDF

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CN105535270A
CN105535270A CN201610047000.6A CN201610047000A CN105535270A CN 105535270 A CN105535270 A CN 105535270A CN 201610047000 A CN201610047000 A CN 201610047000A CN 105535270 A CN105535270 A CN 105535270A
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pharmaceutical composition
scapulohumeral periarthritis
crude drug
cure scapulohumeral
ethanol
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不公告发明人
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Jinan Xingyi Medical Technology Co Ltd
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Abstract

The invention discloses a medicine composition for treating scapulohumeral periarthritis and a preparation method thereof. The medicine composition is prepared from gynostemma pentaphylla, marmor serpentinatum, amur lilac seeds, fruits of indian stringbush, saussurea involucrate and native copper in a matching mode. Various dosage forms can be prepared according to a normal formulation technology, and the medicine composition has the remarkable effect on treating the scapulohumeral periarthritis.

Description

The pharmaceutical composition of cure scapulohumeral periarthritis
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to pharmaceutical composition of a kind of cure scapulohumeral periarthritis and preparation method thereof.
Background technology
Scapulohumeral periarthritis is the chronic aseptic inflammation of the soft tissues such as shoulder joint Surrounding muscles, tendon, synovial bursa and joint capsule.Inflammation causes the outer adhesion of intraarticular, thus affects the activity of shoulder joint.Its lesion characteristic is extensive, and namely pain is extensive, function limitation is extensive, tenderness is extensive.The full name of scapulohumeral periarthritis is scapulohumeral periarthritis, and primary disease is apt to occur in the people of about 50 years old, therefore also known as bursitis of shoulder.After ill, shoulder joint can not be moved, frozen or solidify seemingly, therefore claims congealed shoulder; Scapulohumeral periarthritis.
The sickness rate of scapulohumeral periarthritis accounts for the 2%-5% of total population.The sickness rate of women is a little more than male.It is higher that the sickness rate in left side seems compared with right side, and the scapulohumeral periarthritis betiding bilateral accounts for 12% of total incidence.Also can there is the scapulohumeral periarthritis of offside in the side scapulohumeral periarthritis patient of about 40% in 5-7.Therefore, scapulohumeral periarthritis is also a kind of commonly encountered diseases and frequently-occurring disease of having a strong impact on middle-aged and elderly people daily life.Scapulohumeral periarthritis Therapeutic Method common at present has following several: massage treatment, treatment by Chinese herbs, cupping for treatment, acupuncture and moxibustion therapy, physical therapy etc.Though these methods have certain curative effect, but unsatisfactory.
Herb Gynostemmae Pentaphylli: be cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemmapentaphyllum(Thunb.) herb of Mak..Autumn gathers, and dries.[original shape state] is perennial climbs up by holding on to draft.Stem is elongated, hairiness or without hair, tendril normal 2 splits or do not divide on joint.Leaf bird foot shape, be often made up of 5 ~ 7 lobules, lobule length of a film ellipticity lanceolar is to avette, and have petiolule, middle lobule length of a film 3 ~ 9cm, wide 1.5 ~ 3cm, there is sawtooth at edge, the back side or have short bristle or near without hair along two sides vein.Panicle; Spend little, diameter is about 3mm; Calyx lobes triangle, is about 0.5mm; Corolla lobe lanceolar, is about 2mm.Fruit is spherical, black time ripe.7 ~ August of florescence, really 9 ~ October of phase.[nature and flavor] are cold in nature, bitter in the mouth.[function cures mainly] eliminating inflammation and expelling toxin, eliminating phlegm and stopping cough.Existing multiplexly make strengthening by means of tonics medicine.[extracts] " * dictionary ".
Ophicalcitum: this product is metamorphic rock rocks ophicalcite.After excavating, except roguing stone and silt.[character] this product is granular and aggregation that is compact massive.In irregular bulk.Tool corner angle, and not sharp.White or light gray-white, wherein accompany the serpentine of point-like or strip, in light green color or faint yellow, practises and claim " halo of many colours ", and observing light has flash star shape gloss.Body weight, matter is hard, not easily broken.Odorless, lightly seasoned.[nature and flavor] are sour, puckery, flat.[return through] returns Liver Channel.[function cures mainly] removing stasis to stop bleeding.For spitting of blood, spit blood, traumatic hemorrhage, falls and flutters the pain of injury.[extracts] " Chinese Pharmacopoeia ".
Cortex Syringae: Oleaceae genus syringa syringa reticulata var mandshurica Syringareticulata(Blume) Haravar.mandshurica(Maxim.) Hara, is used as medicine with trunk and branch.The whole year can adopt, and fells as well, is cut into segment, using fresh herb or dry with March in October to next year.[nature and flavor] are bitter, are slightly cold.[function cures mainly] lung heat clearing away, sputum eliminating, relieving cough and asthma.For cough, bronchitis, bronchial asthma.[extracts] " national Chinese herbal medicine compilation ".
Fructus Wikstroemae: medical material Ji Yuan: be the fruit of Isolated From Thymelaeaceae Species wikstroemia indica Wikstroemiaindica (L.) C.A.Mey..Latin plant animal mineral name: Wikstroemiaindica (L.) C.A.Mey. [DaphneindicaL.].Pluck during fruit maturation in autumn, dry.[original shape state] wikstroemia indica half evergreen dwarf shrub, up to 1m.Herb is level and smooth without hair.Stem is upright, multi-branched, sprout bronzing.Root bark and peel of stem are rich in continuous shape fiber, not frangibility.Leaf to life, a few stockless; Blade obovate is to oblong, and long 2-5cm, wide 0.8-1.5cm, the blunt or short point of tip, Quan Yuan, base portion wedge shape, lateral vein is most, extremely very thin, brown time dry.Brightly yellowish green, number flowers are born in Zhi Ding, line up cymose umbel or the head inflorescence in nearly stockless; Flower both sexes, without bract, perianth tubulose, tip 4 splits, without hair; Stamen 8, become upper and lower two-wheeled in raw perianth tube, filigree is short, and flower pesticide is oval; Ovary obovate or oblong, tool round end capitate stigma.Drupe is avette or oval, cerise time ripe.Flowering fruit bearing stage summer, autumn.[chemical analysis] seed contains Saponin, flavonoid, and containing volume oils and fats.[nature and flavor] are pungent; Cold nature; Poisonous.[return through] heart channel.[function cures mainly] detoxicating and resolving stagnation of pathogens.Main carbuncle; Scrofula; Wart wart.[extracts] " China's book on Chinese herbal medicine ".
Herba Saussureae Involueratae: medical material Ji Yuan: be the wounded in the battle Herb of feverfew snow lotus of big bud flower.Latin plant animal mineral name: gather when the SaussureainuolucrataKar.EtKir.6-7 month blooms, removing silt, dries.[original shape state] snow lotus of big bud flower perennial herb, high 15-35cm.Root is sturdy, and base portion is had the residual phyllopodium of most fibrous sepias.Stem is sturdy, and diameter is strengthened, and diameter 2-3cm, without hair.Leafage is raw, intensive, without petiole; Blade mostly is down lanceolar, Long Circle or ovum shape Long Circle, reaches 14cm, wide 2-3.5cm, and tip is blunt or slightly sharp, and base portion is downward, edge pointed tooth, and there is pointed tooth at edge, and two sides is without hair, and between cog has capitate trichomes; Topmost has 13-17 to line up the film quality bract of two layers, wide 5-7cm, and top is gradually sharp, edge pointed tooth, often exceeds 2 times of inflorescence.Head inflorescence, top is raw, and 10-20 is individual at the intensive glomeration of stem end, without stalk; Involucre hemispherical, phyllary 3-4 layer, lanceolar, tip point, edge or all black, is become mildewed to dredge in vain; Corolla purple, is about 14mm; Hua Quan is tubulose, brown purple.Achene, Long Circle, is about 5mm, tool rib, tool 2 layers of pappus, and outer short, internal layer is long, the dirty white of pappus, outer rough hair shape, internal layer featheriness.The florescence 6-7 month.How broken [character] character identification medical material is.Root sepia, lignifying, outside cork is often in grating flaking, and fracture is coarse, inner yellow-white.Micro-hardship, micro-fragrance.Rhizome tubbiness, cervical region is remaining numerous phyllopodium fiber.Stem is sturdy, and tool indulges rib rib, hollow.Leaf comes off more, leaves residue, dense arrangement; In long avette or lanceolar after intact leaves flattens, there are sawtooth and echinid in edge, yellow green, nearly keratin.Bract is long avette or avette, yellow-white, film quality.Head inflorescence 10-30 intensive glomeration, obstructs extremely short; Involucre is hemispherical; Phyllary 3-4 arranges, lanceolar, much more outer in brown, outer surface by numerous pubescence, internal layer brown color or yellow-white, tip is by pubescence; Be all tubular flower, corolla is purplish red, flower pesticide purple, and pistil stigma 2 splits, and is slightly longer than stamen.Achene is long avette, and tool indulges rib, canescence.Mildly bitter flavor, the special fragrance of tool.[pharmacological action] 1. antitumaous effect: by In vitro culture [3H] TdR incorporation methods, cultivate 12,24,36 and 48 hours, observe Herba Saussureae Involueratae flavone compound 4 ', 5,7-trihydroxy 3 ', 6-dimethoxy flavone and dinatin, all can obviously suppress the DNA of ascitic type liver cancer and euphorbia egg decoctum cancerous cell to synthesize.The two ID50 synthesized ascites hepatoma cells DNA is 70.8 μ g/ml and 116 μ g/ml, higher than the suppression to euphorbia egg decoctum.4 ', 5,7-trihydroxy-3 ', 6-dimethoxy flavone may be DNA profiling damage type to the suppression mechanism that cancerous cell DNA synthesizes.The ID50 that Herba Saussureae Involueratae alkaloid synthesizes L7712 cancerous cell DNA is 5l.7g/ml.Total alkaloids 80g/ml has the inhibitory action shown to DNA, RNA and protein.The suppression ratio of effect in 24 hours is all more than 80%.The suppressor mode synthesized RNA may be template damage type.2. the effect of pair cardiovascular system: 2.1. Herba Saussureae Involueratae total alkali and Herba Saussureae Involueratae ethanol abstract all can reduce the dermovascular permeability of rabbit, act on stronger.2.2. Herba Saussureae Involueratae total alkali can make in vitro rabbit ear vasoconstriction, and ethanol abstract presents dilating effect to blood vessel.2.3. Herba Saussureae Involueratae total alkali and total flavones all can reduce the blood pressure of Anaesthetic Rabbits and anesthetized dog.2.4. Herba Saussureae Involueratae total alkali has inhibitory action to extrasomatic rabbit heart, its shrinkage amplitude can be made to diminish, decreased heart rate, even stops to fight.2.5. Herba Saussureae Involueratae total alkali to rabbit Electrocardiogram Feature be decreased heart rate, T ripple become convex, sustainable 10 minutes.3. the effect of pair smooth muscle: the isolated rabbit smooth muscle spasm that Herba Saussureae Involueratae total alkali causes histamine, pilocarpine and acetylcholine, has the spasmolysis shown; Herba Saussureae Involueratae total alkali can partly to the isolated tracheal narrowing of the ring effect that antihistamine causes.4. antiinflammatory action: 5% Herba Saussureae Involueratae total alkali 2ml/kg and Herba Saussureae Involueratae ethanol extraction 10g(crude drug) ankle joint acute inflammation has the antagonism shown after the rat that all causes egg white solution of/kg lumbar injection, but the strongest with total alkali effect, its action intensity is similar to sodium salicylate.In addition, total alkali has the effect reducing rabbit vascular permeability.5. free radical resisting and antifatigue effect.[nature and flavor] bitter in the mouth; Pungent; Hot in nature; Poisonous.[function cures mainly] warming the kidney to activate YANG; Expelling wind and dampness; Promoting blood circulation to restore menstrual flow.Main sexual impotence; Waist knee joint is weak; Rheumatic arthralgia; Menoxenia; Amenorrhea; Cold womb is suffered from abdominal pain; Cold fluid-retention is coughed.[extracts] " China's book on Chinese herbal medicine ".
Pyritum: this product is sulfide-based mineral yellow iron mine race pyrite.Main containing ferrous disulfide (FeS2).After excavating, removing impurity.[character] this product crystal form mostly is cube, and aggregation is compact massive.Surface is bright faint yellow, has metallic luster; Some yellowish-brown or sepia, without metallic luster.Tool striped, the green black of streak or brownish red.Body weight, matter is hard or slightly crisp, easily smashes, and section yellow-white, has metallic luster; Or section sepia, visible silvery white bright star.[nature and flavor] are pungent, flat.[return through] returns Liver Channel.[function cures mainly] dissipating blood stasis, synthetism, pain relieving.For tumbling and swelling, injured bone.[extracts] " Chinese Pharmacopoeia ".
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective cure scapulohumeral periarthritis and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this cure scapulohumeral periarthritis are:
Herb Gynostemmae Pentaphylli 80-100g, Ophicalcitum 130-150g, Cortex Syringae 50-70g, Fructus Wikstroemae 200-220g, Herba Saussureae Involueratae 180-200g, Pyritum 10-15g.
Preferably be used for the treatment of the pharmaceutical composition of scapulohumeral periarthritis, be made up of the crude drug of following weight portion:
Herb Gynostemmae Pentaphylli 90g, Ophicalcitum 140g, Cortex Syringae 60g, Fructus Wikstroemae 210g, Herba Saussureae Involueratae 190g, Pyritum 12g.
A pharmaceutical composition for cure scapulohumeral periarthritis, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
A pharmaceutical composition for cure scapulohumeral periarthritis, is characterized in that the cure scapulohumeral periarthritis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
A preparation method for the pharmaceutical composition of cure scapulohumeral periarthritis, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herb Gynostemmae Pentaphylli 80-100g, Ophicalcitum 130-150g, Cortex Syringae 50-70g, Fructus Wikstroemae 200-220g, Herba Saussureae Involueratae 180-200g, Pyritum 10-15g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
The preparation method of the pharmaceutical composition of preferred a kind of cure scapulohumeral periarthritis, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herb Gynostemmae Pentaphylli 90g, Ophicalcitum 140g, Cortex Syringae 60g, Fructus Wikstroemae 210g, Herba Saussureae Involueratae 190g, Pyritum 12g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
A preparation method for the pharmaceutical composition of cure scapulohumeral periarthritis, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
A preparation method for the pharmaceutical composition of cure scapulohumeral periarthritis, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form cure scapulohumeral periarthritis medicine.
Detailed description of the invention
Embodiment 1: pharmaceutical composition of cure scapulohumeral periarthritis and preparation method thereof
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are: Herb Gynostemmae Pentaphylli 90g, Ophicalcitum 140g, Cortex Syringae 60g, Fructus Wikstroemae 210g, Herba Saussureae Involueratae 190g, Pyritum 12g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 2: pharmaceutical composition of cure scapulohumeral periarthritis and preparation method thereof
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are: Herb Gynostemmae Pentaphylli 80g, Ophicalcitum 150g, Cortex Syringae 50g, Fructus Wikstroemae 220g, Herba Saussureae Involueratae 180g, Pyritum 15g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 3: pharmaceutical composition of cure scapulohumeral periarthritis and preparation method thereof
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are: Herb Gynostemmae Pentaphylli 100g, Ophicalcitum 130g, Cortex Syringae 70g, Fructus Wikstroemae 200g, Herba Saussureae Involueratae 200g, Pyritum 10g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 82g, adds starch 58g, mixing, granulates, dry, adds microcrystalline Cellulose 10g, magnesium stearate 1g, and mixing, is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 85g, adds starch 65g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains medicament composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 180g water-bath (80 DEG C) heating boils molten, add embodiment 3 pharmaceutical composition 30g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 8 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 1.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: the pharmaceutical composition of cure scapulohumeral periarthritis
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are:
Fructus Wikstroemae 280g, Herba Saussureae Involueratae 300g, Pyritum 8g.
Embodiment 8: the pharmaceutical composition of cure scapulohumeral periarthritis
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are:
Fructus Wikstroemae 260g, Herba Saussureae Involueratae 320g, Pyritum 6g.
Embodiment 9: the pharmaceutical composition of cure scapulohumeral periarthritis
The composition of the crude drug of the pharmaceutical composition of cure scapulohumeral periarthritis and weight portion are:
Fructus Wikstroemae 300g, Herba Saussureae Involueratae 280g, Pyritum 10g.
Experimental example 1: the experimental study of cure scapulohumeral periarthritis
1, clinical data
Choose institute of traditional Chinese medicine of Shandong Province Pain Management scapulohumeral periarthritis patient 100 example in May ,-2013 in May, 2012 (wherein outpatient 80 example. inpatient 20 example). man 40 example, female 60 example, the oldest 71 years old, minimum 40 years old, average 52 years old, the longest l1 of the course of disease is the shortest 2 months, average 4.1 years, this group case diagnosis all met " Chinese medical disease Standardization of diagnosis and curative effect ".
2, Therapeutic Method
This pharmaceutical composition oral (embodiment 1 pharmaceutical composition lot number 20111016), each 1.5g, every day 3 times, 1 week is the course for the treatment of, serve on 3 weeks observe the curative effect.
3, criterion of therapeutical effect
Cure: shoulder pain disappears, and shoulder joint function recovers substantially; Take a turn for the better: shoulder pain alleviates, shoulder joint function improves; Invalid: symptom is without improvement.
4, therapeutic outcome
This group 100 example. cure 59 examples (accounting for 59.0%), take a turn for the better 37 examples. invalid 4 examples. total effective rate is 96.0%.
Experimental example 2: model case
Poplar XX, man, 45 years old, start right hand pain in January, 2011, then left hand pain, treated by acupuncture and moxibustion at local hospital, takes a turn for the better at that time.During in February, 2013, left hand recurrent pain, weighs day by day, left hand pain, left hand can not lifted, unable, numb, need just can lift with right hand help, needing when walking just can not be bitterly by left hand clamping, also with shake pain, can live also very inconvenient during cough, his Qu Liaoduojia hospital, do many treatments, still cannot remove pain.Start on July 11st, 2013 to take this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20111016), each 1.5g, every day 3 times, a lot of with regard to feeling relaxed after serveing on 3 weeks, left hand has been dared, and continues again to take and has cured completely for 3 weeks.
Lee XX, female, 52 years old, on May 18th, 2013, left finesse can feel very pain firmly time, and after particularly getting up, pain is more serious, and wrist portion is swollen with, left hand limitation of activity.By checking, her left hand of diagnosis has suffered from carpal joint synovitis, and shoulder also suffers from scapulohumeral periarthritis.Start on August 10th, 2013 to take this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20111016), each 1.5g, every day 3 times, after serveing on 3 weeks, shoulder pain is mild, and hands also can have been lifted, and continues again to take and has cured completely for 4 weeks.

Claims (8)

1. a pharmaceutical composition for cure scapulohumeral periarthritis, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Herb Gynostemmae Pentaphylli 80-100g, Ophicalcitum 130-150g, Cortex Syringae 50-70g, Fructus Wikstroemae 200-220g, Herba Saussureae Involueratae 180-200g, Pyritum 10-15g.
2. the pharmaceutical composition of a kind of cure scapulohumeral periarthritis according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Herb Gynostemmae Pentaphylli 90g, Ophicalcitum 140g, Cortex Syringae 60g, Fructus Wikstroemae 210g, Herba Saussureae Involueratae 190g, Pyritum 12g.
3. the pharmaceutical composition of a kind of cure scapulohumeral periarthritis according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
4. the pharmaceutical composition of a kind of cure scapulohumeral periarthritis according to claim 1, is characterized in that the cure scapulohumeral periarthritis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. a preparation method for the pharmaceutical composition of cure scapulohumeral periarthritis, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herb Gynostemmae Pentaphylli 80-100g, Ophicalcitum 130-150g, Cortex Syringae 50-70g, Fructus Wikstroemae 200-220g, Herba Saussureae Involueratae 180-200g, Pyritum 10-15g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
6. the preparation method of a kind of pharmaceutical composition of cure scapulohumeral periarthritis according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Herb Gynostemmae Pentaphylli 90g, Ophicalcitum 140g, Cortex Syringae 60g, Fructus Wikstroemae 210g, Herba Saussureae Involueratae 190g, Pyritum 12g;
Preparation method: get Herb Gynostemmae Pentaphylli by crude drug proportioning, Ophicalcitum, Cortex Syringae, Fructus Wikstroemae, Herba Saussureae Involueratae, Pyritum, mixing, with weight percent concentration 55% ethanol as solvent, extract at 55 DEG C of warm macerating, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 16 times of crude drug gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, be concentrated into relative density 1.13, filter, medicinal liquid is by HP50 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting HP50 macroporous adsorptive resins of weight percent concentration 75% again, collect weight percent concentration 75% ethanol elution, reclaim ethanol, concentrate drying, obtain pharmaceutical composition.
7. the preparation method of a kind of pharmaceutical composition of cure scapulohumeral periarthritis according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet or capsule or drop pill.
8. the preparation method of a kind of pharmaceutical composition of cure scapulohumeral periarthritis according to claim 5, is characterized in that pharmaceutical composition and chemical drugs or Chinese medicine form cure scapulohumeral periarthritis medicine.
CN201610047000.6A 2016-01-25 2016-01-25 Medicine composition for treating scapulohumeral periarthritis Withdrawn CN105535270A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668438A (en) * 2016-12-10 2017-05-17 济南昊雨青田医药技术有限公司 Medical composition for treating scapulohumeral periarthritis and preparation method of medical composition
CN106728445A (en) * 2016-12-10 2017-05-31 济南昊雨青田医药技术有限公司 Pharmaceutical composition of cure scapulohumeral periarthritis and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106668438A (en) * 2016-12-10 2017-05-17 济南昊雨青田医药技术有限公司 Medical composition for treating scapulohumeral periarthritis and preparation method of medical composition
CN106728445A (en) * 2016-12-10 2017-05-31 济南昊雨青田医药技术有限公司 Pharmaceutical composition of cure scapulohumeral periarthritis and preparation method thereof

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