CN105498869B - A kind of micro-nano drop preparation method - Google Patents
A kind of micro-nano drop preparation method Download PDFInfo
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- CN105498869B CN105498869B CN201510848204.5A CN201510848204A CN105498869B CN 105498869 B CN105498869 B CN 105498869B CN 201510848204 A CN201510848204 A CN 201510848204A CN 105498869 B CN105498869 B CN 105498869B
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- Prior art keywords
- shower nozzle
- mother liquor
- drop
- working solution
- micro
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
Abstract
The present invention relates to a kind of micro-nano drop preparation method, belong to microfluid and technical field of micro-nano manufacture.The micro-nano drop preparation method invented is first by the fine shower nozzle insertion working environment liquid medium mutually insoluble with working solution in shower nozzle；Then working solution is slowly extruded from spray orifice, and one is formed in shower nozzle end and be connected with working solution in shower nozzle and spray orifice and the mother liquor drop bigger than injection diameter, mother liquor drop is surrounded by working environment liquid medium；Dripped by the quick resorption mother liquor of spray orifice afterwards, the size for causing mother liquor to drip reduces rapidly, become small mother liquor drop, finally cause that the small mother liquor drop formed in shower nozzle end departs from the working solution in shower nozzle and spray orifice using Rayleigh instability effect, so as to prepare micro-nano drop of the size less than injection diameter.
Description
Technical field
The invention belongs to microfluid and technical field of micro-nano manufacture, it is related to a kind of micro-nano drop preparation method.
Technical background
Micro-nano drop is in inkjet printing, cell printing, medical equipment spraying, integrated circuit printing, depositing nano-materials
There is important application effect Deng field.At present, it is main using thermal bubble type shower nozzle, piezoelectric type shower nozzle, micro-syringe formula both at home and abroad
The methods such as shower nozzle, electrohydrodynamic formula shower nozzle, magnetic valve controlled property shower nozzle and pneumatic atomizing type spray head generate micro-nano drop.Its
Middle thermal bubble type shower nozzle and piezoelectric type showerhead approach are the most ripe.
Thermal bubble type showerhead approach with the thin film resistor in shower nozzle as heating element heater, when an electric pulse puts on shower nozzle
When, electric current flows through this resistor generation heat makes the liquid evaporation being in contact with it, and bubble is formed outside resistance, and bubble is at shower nozzle
Expand and make liquid to be sprayed from shower nozzle in droplets.
The flex effect that piezoelectric type showerhead approach is produced using the piezo-electric crystal in shower nozzle under pulse voltage effect, makes spray
Liquid storage box volume in head changes, and the change of volume causes the moment that pressure or speed occur in shower nozzle internal liquid to become
Change, these change so that liquid sprays from shower nozzle in droplets in shower nozzle.
Liquid viscosity is the maximum factor of the micro-nano drop jeting effect of influence.When drop sprays, injection can be converted into liquid
The kinetic energy of drop, at the same with liquid viscous dissipation and overcome the energy consumption of surface tension of liquid, the viscosity for spraying drop can not
Too high, existing commercialized displacement type shower nozzle can only spray liquid of the viscosity less than 20cps.Conventional dilution and heating means can
To reduce viscosity, but would generally also change liquid property or extension course of injection.The binding agent that thermal bubble type shower nozzle can spray
It is limited, particularly it is difficult to spray viscosity larger binding agent and nonaqueous binders.Another difficult point is, in injection liquid
Usually there are little particle, such as polymer, medicine even cell, this easily causes spray orifice blocking.Can be compared with using large aperture spray orifice
This problem is solved well, but the particle diameter of injection drop can be made to become big.
The content of the invention
It is an object of the invention to provide a kind of micro-nano drop preparation method, sprayed for cell printing, medical equipment,
The fields such as integrated circuit printing, depositing nano-materials.
Principle of the invention is：The micro-nano drop preparation method invented is first by the insertion of fine shower nozzle and work in shower nozzle
Make liquid mutually in insoluble working environment liquid medium；Then it is slow from spray orifice to extrude working solution, and form one in shower nozzle end
Individual to be connected with working solution in shower nozzle and spray orifice and the mother liquor drop bigger than injection diameter, the mother liquor is dripped by working environment liquid medium bag
Round；Dripped by the quick resorption mother liquor of spray orifice afterwards, the size for causing mother liquor to drip reduces rapidly, become small mother liquor drop, most
Cause that the small mother liquor drop formed in shower nozzle end takes off with the working solution in shower nozzle and spray orifice using Rayleigh instability effect afterwards
From so as to prepare micro-nano drop of the size less than injection diameter.
Advantages of the present invention is as follows：
1. micro-nano drop of the particle diameter less than injection diameter can be prepared using the shower nozzle of larger injection diameter.
2. can prepare and contain suspended particulate and high-viscosity micro-nano drop.
3. simple to operate.
4. the requirement of pair equipment is low.
Brief description of the drawings
Fig. 1 is micro-nano drop preparation principle schematic diagram.
Fig. 2 is that fine shower nozzle extrusion liquid body prepares the principle schematic that mother liquor drips process.
Fig. 3 is principle schematic of the fine shower nozzle resorption mother liquor dripping for micro-nano drop process.
Specific embodiment
Referring to Fig. 1.The method that the present invention prepares micro-nano drop is that fine shower nozzle first is inserted into mutual with working solution in shower nozzle
In insoluble working environment liquid medium；Then it is slow from spray orifice to extrude working solution, and one is formed with spray in shower nozzle end
Working solution is connected and the mother liquor drop bigger than injection diameter in head and spray orifice, and mother liquor drop is surrounded by working environment liquid medium,
The specific forming process of mother liquor drop is referring to Fig. 2；Dripped by the quick resorption mother liquor of spray orifice afterwards, the size for causing mother liquor to drip subtracts rapidly
It is small, become small mother liquor drop, finally caused using Rayleigh instability effect the small mother liquor drop that is formed in shower nozzle end with
Working solution in shower nozzle and spray orifice departs from, so as to prepare micro-nano drop of the size less than injection diameter, micro-nano drop
Specific forming process is referring to Fig. 3.
Referring to Fig. 2.Situation when Fig. 2 (a) is shower nozzle end dripless, does not now apply extruding and makees to the liquid in spray orifice
Firmly；Fig. 2 (b) is the situation that shower nozzle end has just initially formed mother liquor drop, has now just started to apply extruding to the liquid in spray orifice
Active force, the slow speed of working solution extrusion process is carried out, with keep be extruded working solution mother liquor drop not with shower nozzle and spray orifice in
Working solution departs from；It is the slow process for expanding of mother liquor drop of shower nozzle end from Fig. 2 (c) to Fig. 2 (g)；When squeezing action to Fig. 2
Stop when (g), now form one in shower nozzle end is connected and the mother liquor bigger than injection diameter with working solution in shower nozzle and spray orifice
Drop.
Referring to Fig. 3.Fig. 3 (h) is just to have started situation when quick resorption mother liquor drips；It is nozzle end from Fig. 3 (i) to Fig. 3 (l)
The mother liquor drop in portion reduces the process of change, and it is rapid that it reduces change procedure；Due to Rayleigh instability effect when reaching Fig. 3 (m)
So that depart from the working solution in shower nozzle and spray orifice in the small mother liquor drop that shower nozzle end is formed, so as to prepare size less than spray
The micro-nano drop of head bore diameter, is shown in Fig. 3 (n).
Claims (2)
1. a kind of micro-nano drop preparation method, it is characterised in that：Fine shower nozzle is first inserted mutually insoluble with working solution in shower nozzle
Working environment liquid medium in；Then the slow extrusion working solution from spray orifice, and shower nozzle end formed one with shower nozzle and
Working solution is connected and the mother liquor drop bigger than injection diameter in spray orifice, and mother liquor drop is surrounded by working environment liquid medium；Afterwards
Dripped by the quick resorption mother liquor of spray orifice, the size for causing mother liquor to drip reduces rapidly, become small mother liquor drop, finally using Rayleigh
Instability effect causes that the small mother liquor drop formed in shower nozzle end departs from the working solution in shower nozzle and spray orifice, so as to prepare
Go out micro-nano drop of the size less than injection diameter.
2. micro-nano drop preparation method according to claim 1, it is characterized in that, the slow speed of working solution extrusion process is entered
OK, do not departed from the working solution in shower nozzle and spray orifice with keeping the working solution mother liquor being extruded to drip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510848204.5A CN105498869B (en) | 2015-11-27 | 2015-11-27 | A kind of micro-nano drop preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510848204.5A CN105498869B (en) | 2015-11-27 | 2015-11-27 | A kind of micro-nano drop preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105498869A CN105498869A (en) | 2016-04-20 |
| CN105498869B true CN105498869B (en) | 2017-06-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510848204.5A Active CN105498869B (en) | 2015-11-27 | 2015-11-27 | A kind of micro-nano drop preparation method |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105420763B (en) * | 2015-12-03 | 2017-08-11 | 中国石油大学(华东) | Micro-nano electrochemical deposition processing method based on drop taylor cone |
| JP7220366B2 (en) | 2018-01-24 | 2023-02-10 | 思納福（蘇州）生命科技有限公司 | MOTION CONTROL MECHANISM, LIQUID EJECTING PIPETTIP, MICRO-DROPLET GENERATING DEVICE AND METHOD, FLUID DRIVING MECHANISM AND FLUID DRIVING METHOD, MICRO-DROPLET GENERATING METHOD, AND SURFACE-TREATING METHOD OF LIQUID-JETTING PIPETTIP |
| EP3739323A4 (en) | 2018-01-24 | 2021-03-17 | Sniper (Beijing) Medical Technologies Co., Ltd | Microdroplet container, method for preparing microdroplet container, microdroplet spreading method, microdroplet formation kit, temperature control device, oil phase composition for microdroplet formation and treatment method therefor |
| CN110064452B (en) * | 2018-01-24 | 2022-02-01 | 思纳福(北京)医疗科技有限公司 | Method for producing micro-droplets |
| CN109865904B (en) * | 2019-02-01 | 2020-11-03 | 清华大学 | Method and device for operating micro-droplets by using micro-hydrophilic probe in electric spark machining |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070054119A1 (en) * | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
| GB0712863D0 (en) * | 2007-07-03 | 2007-08-08 | Eastman Kodak Co | Monodisperse droplet generation |
| DE102010019612A1 (en) * | 2010-05-06 | 2011-11-10 | Dürr Systems GmbH | Coating device, in particular with an application device, and associated coating method that emits a droplets of coating agent droplet |
| CN104324769B (en) * | 2014-11-17 | 2016-06-22 | 中国科学院微生物研究所 | Generation method based on the drop of microchannel |
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