CN105497672A - 一种治疗风湿性关节炎的沐浴粉及其制备方法 - Google Patents
一种治疗风湿性关节炎的沐浴粉及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗风湿性关节炎的沐浴粉及其制备方法,其主要是由三七、石斛、鹿衔草、蜂房、豨莶草、木瓜、乌梢蛇按一定重量配比制备而成,本发明具有散瘀消肿、活络定痛、祛风除湿、活血调经的功能,用于治疗风湿性关节炎疗效好,无副作用。
Description
技术领域
本发明涉及一种治疗风湿性关节炎的沐浴粉及其制备方法,属中药领域。
背景技术
风湿性关节炎属***反应性疾病,多以急性发热及关节疼痛起病,典型表现是轻度或中度发热,游走性多关节炎,受累关节多为膝,踝、肩、肘,腕等大关节,常见由一个关节转移至另一个关节,病变局部呈现红,肿、灼热、剧痛,部分病人也有几个关节同时发病,不典型的病人仅有关节疼痛而无其他炎症表现,若风湿活动影响心脏,则可发生心肌炎,甚至遗留心脏瓣膜病变。由于目前西药无法快速有效的治疗风湿性关节炎,因此人们对治疗风湿性关节炎的中药制品存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和试验的反复验证,终于研制出了治疗风湿性关节炎的沐浴粉,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗风湿性关节炎的沐浴粉。
本发明的另一目的就是提供了该沐浴粉的制备方法。
本发明是选择三七、石斛、鹿衔草、蜂房、豨莶草、木瓜、乌梢蛇、薏苡仁、秦艽、紫河车、木通、狗脊、细辛、鸡血藤、大枣、僵蚕、萆薢、海桐皮、虎杖、淫羊藿、紫草、蓖麻子、千年健、茄根、花椒、丝瓜络、水菖蒲、巴戟天、桑叶、麦饭石、桑寄生、高粱酒进行组合的,将这些原料组合使得各药物功效产生协同作用,从而起到治疗风湿性关节炎的功效。其中选用三七是因为其性味甘微苦,温,入肝、胃、大肠经,有止血,散瘀,消肿,定痛的功能,治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用鹿衔草是因为其性味甘苦,温,入肝、肾二经,有补虚,益肾,祛风除湿,活血调经的功能,治虚弱咳嗽,劳伤吐血,风湿性关节炎关节痛,崩漏,白带,外伤出血。选用蜂房是因为其性味甘,平,归胃经,有祛风,攻毒,杀虫,止痛的功能,用于龋齿牙痛,疮疡肿毒,乳痈,瘰疬,皮肤顽癣,鹅掌风。选用豨莶草是因为其性味苦,寒,入肝、脾、肾经,有祛风湿性关节炎,利筋骨,降血压的功能,治四肢麻痹,筋骨疼痛,腰膝无力,疟疾,急性肝炎,高血压病,疔疮肿毒,外伤出血。选用木瓜是因为其性味酸,温,入肝、脾经,有平肝和胃,去湿舒筋的功能,治吐泻转筋,湿痹,脚气,水肿,痢疾。选用乌梢蛇是因为其性味甘,平,归肝经,有祛风活络,镇痉,治风湿性关节炎痹痛,四肢麻木,抽搐痉挛,皮肤瘙痒,麻风。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿性关节炎痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用紫河车是因为其性味甘咸,温,入肺、肝、肾经,有补气,养血,益精的功能,治虚损,羸瘦,劳热骨蒸,咳喘,咯血,盗汗,遗精,阳痿,妇女血气不足,***或乳少。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用狗脊是因为其性味苦甘,温,入肝、肾经,有补肝肾,除风湿性关节炎,健腰脚,利关节的功能,治腰背酸疼,膝痛脚弱,寒湿周痹,失溺,尿频,遗精,白带。选用细辛是因为其性味辛,温,入肺、肾经,有祛风,散寒,行水,开窃的功能,治风冷头痛,鼻渊,止痛,痰饮咳逆,风湿性关节炎痹痛。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,***。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用萆薢是因为其性味苦,平,入肝、胃、膀胱经,有祛风,利湿的功能,治风湿性关节炎顽痹,腰膝疼痛,小便不利,淋浊,遗精,湿热疮毒。选用海桐皮是因为其性味苦辛,平,入肝、脾经,有祛风湿性关节炎,通经络,杀虫的功能,治风湿性关节炎痹痛,痢疾,牙痛,疥癣。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿性关节炎筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿性关节炎痹痛,四脚不仁。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便秘,烧伤,湿疹,丹毒,痈疡。选用蓖麻子是因为其性味甘辛,平,有毒,入大肠、肺经,有消肿拔毒,泻下通滞的功能,治痈疽肿毒,瘰疬,喉痹,疥癫癣疮,水肿腹满,大便燥结。选用千年健是因为其性味苦、辛,温,归肝、肾经,有祛风湿性关节炎,健筋骨的功能,治风寒湿痹,腰膝冷痛,下肢拘挛麻木。选用茄根是因为其性味甘辛,寒,治久痢便血,脚气,齿痛,冻疮。选用花椒是因为其性味辛,温,有毒,入脾、肺、肾经,有温中散寒,除湿,止痛,杀虫,解鱼腥毒,治积食停饮,心腹冷痛,呕吐,噫呃,咳嗽气逆,风寒湿痹,泄泻,痢疾,疝痛,齿痛,蛔虫病,蛲虫病,阴痒,疮疥。选用丝瓜络是因为其性味甘,平,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经闭,乳汁不通,痈肿,痔漏。选用水菖蒲是因为其性味苦、辛,微温,入心、肺、胃经,有开窍化痰,辟秽杀虫的功能,治痰涎壅闭,神志不清,慢性气管炎,腹胀腹痛,食欲不振,肠炎,痢疾,风湿性关节炎痹痛,外伤疥疮。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿性关节炎的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用桑叶是因为其性味苦甘,寒,入肺、肝经,有祛风清热,凉血明目的功能,治风湿性关节炎发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾疹,下肢象皮肿。选用麦饭石是因为其性味甘,温,归肝、肾、胃经,有解毒散结,去腐生肌,除寒去湿,益肝健胃,活血化瘀,利尿化石,延年益寿的功能,治痈疽发背,痤疮,湿疹,脚气,牙痛,口腔溃疡,风湿性关节炎痹证,腰背痛,慢性肝硬化炎,胃炎,糖尿病,神经衰弱,外伤红肿,高血压,肿瘤,***。选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿性关节炎,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用高粱酒是因为其性味甘,苦辛,温,入心、肺、肝、胃经,有通血脉,御寒气,行药势的功能,治风寒脾痛,筋脉挛急,胸痹,心腹冷痛。
具体实施方式
本发明组合的药物用量也是发明人经过大量摸索总结得出的,各分组的用量在下述重量范围内都具有较好疗效:
三七4-10g、石斛5-12g、鹿衔草4-10g、蜂房5-15g、
豨莶草5-15g、木瓜10-20g、乌梢蛇4-10g、薏苡仁10-20g、
秦艽5-15g、紫河车5-15g、木通10-20g、狗脊5-15g、
细辛6-18g、鸡血藤10-20g、大枣10-20g、僵蚕4-10g、
萆薢4-10g、海桐皮5-15g、虎杖4-12g、淫羊藿10-20g、
紫草5-15g、蓖麻子4-10g、千年健15-25g、茄根15-25g、
花椒5-12g、丝瓜络4-12g、水菖蒲5-15g、巴戟天4-12g、
桑叶5-15g、麦饭石4-10g、桑寄生4-12g、高粱酒1500-2000g。
优选为:
三七8g、石斛9g、鹿衔草8g、蜂房10g、
豨莶草10g、木瓜15g、乌梢蛇6g、薏苡仁15g、
秦艽10g、紫河车10g、木通15g、狗脊10g、
细辛12g、鸡血藤15g、大枣16g、僵蚕7g、
萆薢8g、海桐皮10g、虎杖8g、淫羊藿20g、
紫草10g、蓖麻子7g、千年健20g、茄根20g、
花椒8g、丝瓜络8g、水菖蒲10g、巴戟天8g、
桑叶10g、麦饭石6g、桑寄生8g、高粱酒1600g。
本发明的制备方法如下
一、备料
1、三七:拣尽杂质,捣碎,润透切片晒干;
2、石斛:取干燥的石斛,用水泡至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
3、鹿衔草:拣去杂质,筛去泥沙,洗净,稍润,切细,晒干;
4、蜂房:取原药材,除去杂质,切块,筛去碎屑;
5、豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
6、木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,乘热切片,日晒夜露,以由红转紫黑色为止;
7、乌梢蛇:取原药材,刷去灰屑,用时去头、鳞,切段;
8、薏苡仁:取原药材,除去残留皮壳、杂质;
9、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
10、紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
11、木通:用水稍浸泡,闷润至透,切片,晒干;
12、狗脊:取沙子置锅内炒热,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛除沙子,风晾后,刮净黄绒毛;
13、细辛:除净杂质,用水喷润,及时切段,晒干;
14、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
15、大枣:拣净杂质,晒干;
16、僵蚕:取原药材,除去残丝,杂质;
17、萆薢:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎屑;
18、海桐皮:用清水浸泡,洗净泥屑,切成小块,晒干;
19、虎杖:春秋采挖,切段,晒干;
20、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
21、紫草:洗净,润透,切片,晒干;
22、蓖麻子:敲碎种子外壳,拣取种仁用;
23、千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
24、茄根:全植物枯萎时连根拔起,除去干叶,洗净切片,晒干;
25、花椒:除去果柄及种子椒目,置锅内炒至发响、油出,取出,放凉;
26、丝瓜络:洗净晒干,切段;
27、水菖蒲:取原药材,除去芦衣、杂质,洗净,润透,切厚片,低温干燥;
28、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
29、桑叶:拣去杂质,搓碎,簸去梗,筛去泥屑;
30、麦饭石:除去杂质,洗净,干燥,打成碎块;
31、桑寄生:用水洗净,润透,切段,晒干;
32、高粱酒:选用优质高粱酒;
二、制备
1、将所述的三七、石斛、鹿衔草、蜂房、豨莶草、木瓜、乌梢蛇、薏苡仁、秦艽、紫河车、木通、狗脊、细辛、鸡血藤、大枣、僵蚕、萆薢、海桐皮、虎杖、淫羊藿、紫草、蓖麻子、千年健、茄根、花椒、丝瓜络、水菖蒲、巴戟天、桑叶、麦饭石、桑寄生加水煎煮两次,第一次加水8倍量,煎煮1.5小时,第二次加水6倍量,煎煮1小时,合并两次煎煮液,过滤得滤液;
2、将过滤的滤液浓缩成比重为1.35的浸膏,加90%-95%乙醇进行醇沉,回收乙醇并浓缩,在45-50℃下干燥,制得干浸膏;
3、将干浸膏粉碎成细粉过筛即得沐浴粉。
本发明具有散瘀消肿、活络定痛、祛风除湿、活血调经的功能,用于治疗风湿性关节炎疗效好,无副作用。
具体实施方式:
以下通过试验例来进一步阐述本发明的有益效果,这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。
[试验例1]本发明的动物毒性试验
取西德兔30只,雌雄兼用,体重2.0-2.5kg,先将腹部兔毛拔净露出皮肤,将配置好的药粉调成糊状涂抹在家兔腹部裸露皮肤处,然后用纱布缠缚,每天涂药2次,连续涂药5天,每天观察给药反应,结果表明家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明的试验疗效观察
1、一般资料
收治患者共37例。
2、诊断标准
风湿性关节炎起病较急,受累关节以大关节为主,开始侵及下肢关节者占85%,膝和踝关节最为常见,其次为肩,肘和腕,手和足的小关节少见,关节病变呈多发性和游走性,关节局部炎症明显,表现有晨僵,功能障碍,关节肿胀,压痛及活动受限。
3、治疗方法
(1)把浴缸或浴桶中注入热水,将水温调至40摄氏度左右;
(2)将配制好的沐浴粉加入高粱酒中混合搅拌成药液;
(3)将混合药业按重量比1:100加入浴缸或浴桶水中搅拌均匀;
(4)将患者身体没入浴缸或浴桶中浸泡30-50分钟,每晚一次,连续用药30天。
4、疗效评定标准
显效:风湿性关节炎症状得到控制,治愈;
好转:风湿性关节炎病变症状减轻,关节肿胀消除患者体征得到改善,病情逐步好转;
无效:达不到好转标准者。
5、疗效结果(见下表):
在上述治疗中,用本发明药物治疗风湿性关节炎患者共37例,结果显效33例,显效率为89.2%,好转2例,好转率为5.4%,无效2例,总有效率为94.6%。
Claims (3)
1.一种治疗风湿性关节炎的沐浴粉,其特征在于:它是由下列重量范围内的原料制成:
三七4-10g、石斛5-12g、鹿衔草4-10g、蜂房5-15g、
豨莶草5-15g、木瓜10-20g、乌梢蛇4-10g、薏苡仁10-20g、
秦艽5-15g、紫河车5-15g、木通10-20g、狗脊5-15g、
细辛6-18g、鸡血藤10-20g、大枣10-20g、僵蚕4-10g、
萆薢4-10g、海桐皮5-15g、虎杖4-12g、淫羊藿10-20g、
紫草5-15g、蓖麻子4-10g、千年健15-25g、茄根15-25g、
花椒5-12g、丝瓜络4-12g、水菖蒲5-15g、巴戟天4-12g、
桑叶5-15g、麦饭石4-10g、桑寄生4-12g、高粱酒1500-2000g。
2.根据权利要求1所述的沐浴粉,其中各原料的用量为:
三七8g、石斛9g、鹿衔草8g、蜂房10g、
豨莶草10g、木瓜15g、乌梢蛇6g、薏苡仁15g、
秦艽10g、紫河车10g、木通15g、狗脊10g、
细辛12g、鸡血藤15g、大枣16g、僵蚕7g、
萆薢8g、海桐皮10g、虎杖8g、淫羊藿20g、
紫草10g、蓖麻子7g、千年健20g、茄根20g、
花椒8g、丝瓜络8g、水菖蒲10g、巴戟天8g、
桑叶10g、麦饭石6g、桑寄生8g、高粱酒1600g。
3.根据权利要求1或2所述沐浴粉的制备方法,它包括下列步骤:
(一)备料
(1)三七:拣尽杂质,捣碎,润透切片晒干;
(2)石斛:取干燥的石斛,用水泡至至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
(3)鹿衔草:拣去杂质,筛去泥沙,洗净,稍润,切细,晒干;
(4)蜂房:取原药材,除去杂质,切块,筛去碎屑;
(5)豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
(6)木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,乘热切片,日晒夜露,以由红转紫黑色为止;
(7)乌梢蛇:取原药材,刷去灰屑,用时去头、鳞,切段;
(8)薏苡仁:取原药材,除去残留皮壳、杂质;
(9)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(10)紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
(11)木通:用水稍浸泡,闷润至透,切片,晒干;
(12)狗脊:取沙子置锅内炒热,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛(13)除沙子,风晾后,刮净黄绒毛;
(14)细辛:除净杂质,用水喷润,及时切段,晒干;
(15)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(16)大枣:拣净杂质,晒干;
(17)僵蚕:取原药材,除去残丝,杂质;
(18)萆薢:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎屑;
(19)海桐皮:用清水浸泡,洗净泥屑,切成小块,晒干;
(20)虎杖:春秋采挖,切段,晒干;
(21)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(22)紫草:洗净,润透,切片,晒干;
(23)蓖麻子:敲碎种子外壳,拣取种仁用;
(24)千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
(25)茄根:全植物枯萎时连根拔起,除去干叶,洗净切片,晒干;
(26)花椒:除去果柄及种子椒目,置锅内炒至发响、油出,取出,放凉;
(27)丝瓜络:洗净晒干,切段;
(28)水菖蒲:取原药材,除去芦衣、杂质,洗净,润透,切厚片,低温干燥;
(29)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(30)桑叶:拣去杂质,搓碎,簸去梗,筛去泥屑;
(31)麦饭石:除去杂质,洗净,干燥,打成碎块;
(32)桑寄生:用水洗净,润透,切段,晒干;
(33)高粱酒:选用优质高粱酒;
(二)制备
(1)将所述的合欢皮、神曲、珍珠母、远志、牡丹皮、小麦、太子参、百合、玉竹、龟版、天麻、桔梗加水煎煮两次,第一次加水8倍量,煎煮1.5小时,第二次加水6倍量,煎煮1小时,合并两次煎煮液,过滤得滤液;
(2)将过滤的滤液浓缩成比重为1.35的浸膏,加90%-95%乙醇进行醇沉,回收乙醇并浓缩,在45-50℃下干燥,制得干浸膏;
(3)将干浸膏粉碎成细粉,然后过筛即得。
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