CN105497634B - Zhuang medicine composition for treating rheumatoid arthritis - Google Patents

Zhuang medicine composition for treating rheumatoid arthritis Download PDF

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CN105497634B
CN105497634B CN201511027466.1A CN201511027466A CN105497634B CN 105497634 B CN105497634 B CN 105497634B CN 201511027466 A CN201511027466 A CN 201511027466A CN 105497634 B CN105497634 B CN 105497634B
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rheumatoid arthritis
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庞宇舟
赵自垒
汤倩倩
徐晶
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Guangxi University of Chinese Medicine
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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Abstract

The invention belongs to the field of Zhuang medicine, and discloses a Zhuang medicine composition for treating rheumatoid arthritis; the raw materials comprise, by weight, 20-50 parts of polygonum multiflorum, 20-50 parts of Chinese fevervine herb, 20-40 parts of tinospora sinensis, 20-40 parts of Chinese stephania root, 10-40 parts of leprosy, 10-50 parts of divaricate saposhnikovia root, 10-40 parts of solanum lyratum, 10-30 parts of drynaria rhizome, 10-30 parts of lemongrass herb and 10-30 parts of whiteflower lead. The dosage form is decoction. The preparation method comprises the following steps: cleaning the raw material composition decoction pieces according to the parts by weight respectively, adding water, decocting with slow fire to 200ml, re-decocting the residues, and mixing the decoctions obtained in the two times to obtain decoction. Clinical tests show that the Zhuang medicine composition has the effects of dispelling wind, dredging collaterals, dispelling cold, removing dampness and the like, has obvious effects of dredging collaterals and relieving pain, can obviously improve clinical symptoms such as joint swelling and pain and even deformation and the like, and is a good medicine for treating rheumatoid arthritis.

Description

Zhuang medicine composition for treating rheumatoid arthritis
Technical Field
The invention belongs to the field of national medicine Zhuang medicine, and particularly relates to a Zhuang medicine composition for treating rheumatoid arthritis.
Background
Rheumatoid arthritis is an autoimmune inflammatory disease which is mainly clinically manifested by chronic and symmetrical multiple synovial arthritis and extraarticular diseases, has unknown etiology and does not have a special diagnosis index at present. The clinical manifestations include joint pain, swelling, movement disorder, morning stiffness, long-term joint deformity, anemia, increased RF in laboratory examinations, increased ESR, initial X-ray showing only soft tissue swelling and osteoporosis, and narrowing or difference in joint space in middle and late stages.
The treatment of rheumatoid arthritis aims at controlling the progression of the disease, relieving pain, preventing irreversible bone destruction, protecting the function of joints and muscles, and improving the quality of life of the patient. In recent years, western medicine has made remarkable progress in the research of pathogenesis and pathological changes of rheumatoid arthritis, however, no medicine for treatment and medicine can slow down or prevent the bone invasion and joint destruction of rheumatoid arthritis. There is a lack of effective drugs that really control the progress of the disease.
Nowadays, doctors generally consider rheumatoid arthritis to belong to the category of arthralgia syndrome in traditional Chinese medicine. According to its clinical manifestations, it is similar to the arthralgia syndrome in bone addiction, almanac, white tiger almanac, crane-knee wind, obstinate addiction and Xupu. Physicians in all generations have discussed their pathogenesis. For the research of the etiology of arthralgia syndrome, the "Nei Jing" recognizes that the three qi and blood of wind-cold-dampness are mixed to form the pulse ", the" Wen & febrile disease "indicates that the wind-rain-cold-heat cannot damage the human body alone, and indicates that the wind-rain-cold-heat cannot be mixed with the wind-cold-dampness to form the arthralgia syndrome, so that the pathogenic invasion is the external condition of the disease, and the healthy qi deficiency is the fundamental factor of the disease evolution, and the direct or indirect reasons of the three, namely the cause of the arthralgia syndrome, are caused by the three aspects of the healthy qi deficiency, the pathogenic invasion and the phlegm-tired blood. Zhuang medicine calls the arthralgia syndrome as "exuberant", and considers that the arthralgia syndrome occurs because of invasion of wind-toxin, damp-toxin, measles-toxin, heat-toxin, cold-toxin and the like, strong and weak toxin, failure of body resistance to prevail pathogen, blockage of three channels by pathogenic toxin, failure of three qi in synchronization of heaven and earth people to cause diseases, and joint swelling and pain and even deformation are the main manifestations. Zhuang nationality medicine has been developed for many years for treating rheumatoid arthritis, has the effects of dispelling wind and dredging collaterals, dispelling cold and removing dampness, and has reliable clinical curative effect.
Disclosure of Invention
The invention provides a Zhuang medicine composition for treating rheumatoid arthritis. The pharmaceutical composition is prepared from Zhuang nationality medicines with the effects of dispelling wind, dredging collaterals, dispelling cold, removing dampness and the like, has obvious effects of dredging collaterals and relieving pain, can obviously improve clinical symptoms such as joint swelling and pain and even deformation and the like, and is a good medicine for treating rheumatoid arthritis.
The invention is realized by the following technical scheme:
the Zhuang medicine composition for treating rheumatoid arthritis comprises, by weight, 20-50 parts of polygonum multiflorum, 20-50 parts of paederia scandens, 20-40 parts of tinospora sinensis, 20-40 parts of Chinese stephania root, 10-40 parts of leprosum, 10-50 parts of divaricate saposhnikovia root, 10-40 parts of solanum lyratum, 10-30 parts of rhizoma drynariae, 10-30 parts of lemongrass and 10-30 parts of whiteflower leadword root.
The dosage form is decoction.
The Zhuang medicine composition comprises the following raw materials in part by weight:
and (3) Polygonum flaccidum: the strong name is: nyacijrip. The medicine is as follows: is herba Polygoni Hydropiperis of PolygonaceaeHomalocladium platycladum(f. muell. ex Hook.) whole grass of l.h.bailey. Nature and taste: sweet, bland and mild.The efficacy is as follows: clear heat and toxic materials and dredge Longlu. The main treatment is as follows: carbuncle, sore, rheumatalgia, traumatic injury, snake and insect bite, and Scolopendra bite.
Chinese fevervine herb: the strong name is: gaeuroetma. The medicine is as follows: is herba Paederiae of RubiaceaePaederia scandens(Lour.) stems and leaves of Merr. Nature and taste: sweet, sour and neutral. The efficacy is as follows: dispelling pathogenic wind and removing dampness, promoting digestion and resolving food stagnation, removing toxic substance and detumescence, promoting blood circulation and relieving pain. The main treatment is as follows: rheumatalgia, food stagnation, abdominal distention, infantile malnutrition, diarrhea, dysentery, heatstroke, jaundice, hepatitis, hepatosplenomegaly, cough, scrofula, intestinal carbuncle, innominate toxic swelling, foot dampness swelling, scald, burn, eczema, dermatitis, traumatic injury, and snake flood and scorpion sting.
And (3) widening tendon rattan: the medicine is as follows: for preventing the Chinese TinosporaTinospora sinensis(Lour.) Merr. Nature and taste: slightly bitter taste and cool nature. The efficacy is as follows: dispelling pathogenic wind and relieving pain; relaxing tendons and activating collaterals. The main treatment is as follows: rheumatic arthralgia; lumbar muscle strain; traumatic injury.
Carrying out shoulder pole vine: the medicine is as follows: is a plant of Vitaceae, including radix Alstoniae YunnanensisTetrastigma planicaule(hook.f.) roots or rattans of gagnep. Nature and taste: octyl, sour, ping. The efficacy is as follows: dispelling wind and eliminating dampness; relaxing tendons and activating collaterals. The main treatment is as follows: rheumatic arthralgia; lumbar muscle strain; stroke hemiplegia; traumatic injury.
Numbness and bone wind: the strong name is: gaegugo. The medicine is as follows: is Gnetaceae plant Gnetum lobus GnetumGnetum parvifolium(Warb.) C.Y. Cheng ex Chum stems and leaves. Nature and taste: bitter and warm. The efficacy is as follows: dispel wind and dampness, dissipate blood stasis, resolve phlegm and stop cough. The main treatment is as follows: rheumatalgia, lumbago, arthralgia syndrome, apoplexy, hemiplegia, arthroncus of knee, traumatic injury, hemorrhage due to ulcer, and chronic tracheitis.
And (3) white cowberry stems: the strong name is: gaeumoxgauj. The medicine is as follows: is caulis et folium fici Pumilae of RubiaceaeHedyotis hedyotideaStem and leaf of dc. Nature and taste: sweet, bland and cool. The efficacy is as follows: dispel wind, activate collaterals, relieve swelling and stop bleeding. The main treatment is as follows: rheumatic arthralgia, haemorrhoids, hemorrhage, furuncle, carbuncle and traumatic injury.
Rhizoma drynariae: the strong name is: hingbwn. The medicine is as follows: is prepared from Dryopteris Crassirhizoma of DryopteridaceaeDrynaria fortune(Kunze) j. rhizomes of smith. Nature and taste: sweet, bitter and warm in nature. The efficacy is as follows: tonifying kidney and strengthening bone; promoting blood circulation to arrest pain. The main treatment is as follows: lumbago due to kidney deficiency,Flaccidity of foot and knee, deafness, toothache, rheumatic arthralgia, chronic diarrhea, enuresis, traumatic injury, fracture and alopecia areata.
Divaricate saposhnikovia root: the strong name is: gofangzsingh. The medicine is as follows: is prepared from plants of LabiataeEpimeredi indica(L.) Rothm's whole grass. Nature and taste: pungent, bitter and mild. The efficacy is as follows: dispel wind, remove dampness, remove toxicity, and eliminate carbuncle. The main treatment is as follows: rheumatic arthralgia, hypertension, acute cutaneous syndrome, common cold, fever, emesis, abdominal pain, arthralgia and myalgia, pyocutaneous disease, eczema, and hemorrhoid.
Herba Cymbopogonis Citrari: the medicine is as follows: is herba Cymbopogonis Citrari of GramineaeCymbopogon distans (Nees ex Steud.) W.Wats. Nature and taste: pungent, bitter and warm in nature. The efficacy is as follows: relieve exterior syndrome, remove dampness, relieve cough and relieve dyspnea. The main treatment is as follows: wind-cold type common cold, sunstroke, vomiting and diarrhea, abdominal pain, stranguria with urine, rheumatalgia, cough and asthma.
White lead: the strong name is: godanhhau. The medicine is as follows: is a white flower pill of plumbaginaceaePlumbago zeylanicaL. whole grass. Nature and taste: pungent, bitter, astringent, warm and toxic. The efficacy is as follows: dispel wind, dissipate blood stasis, remove toxicity and kill parasites. The main treatment is as follows: rheumatic arthralgia, stomach ache, toxic by poison, hepatosplenomegaly, liver cirrhosis, fire eyes, skin pruritus, amenorrhea due to blood stasis, traumatic injury, toxic swelling, malignant boil and scabies.
The invention has the beneficial effects that:
in the formula, the polygonum japonicum is mainly used for clearing heat and toxic materials, dredging dragon road, Chinese fevervine herb, tinospora sinensis, leprosy and solanum lyratum are used as monarch drugs for dispelling wind and removing dampness, relaxing tendons and activating collaterals; rhizoma drynariae tonifies the kidney and strengthens the bone, and the divaricate saposhnikovia root and the lemongrass herb regulate qi to relieve pain and expel wind are used as ministerial drugs; the plumbum root, radix Plumbaginis Zeylanicae, has effects of removing blood stasis and relieving swelling, and can be used as adjuvant drug. The whole formula has the functions of expelling wind and removing obstruction in channels, dispelling cold and removing dampness, has obvious effects of removing obstruction in channels and relieving pain, can obviously improve the clinical symptoms of joint swelling and pain and even deformation, and is an effective medicament for treating rheumatoid arthritis.
Detailed Description
The invention is further illustrated by the following examples, which should not be construed as in any way limiting its scope.
Example 1:
a Zhuang medicine composition for treating rheumatoid arthritis comprises the following raw material components: 45g of bunchy knotweed, 45g of Chinese fevervine herb, 40g of tinospora sinensis, 40g of Chinese wingless twig and leaf, 40g of lephanous clematis root, 45g of divaricate saposhnikovia root, 35g of cowherb, 30g of rhizoma drynariae, 30g of lemongrass herb and 30g of whiteflower leadword root. Weighing the raw materials according to weight, respectively selecting the raw materials, pouring the raw materials into a medicine pot, and adding water to soak for 1 hour; decocting for the first time: decocting with strong fire until the decoction is boiling, decocting with slow fire for 25 min, and filtering to obtain filtrate; decocting for the second time: adding water at normal temperature into the pot until the water is 0.5 cm higher than the medicinal material plane, decocting with strong fire until boiling, decocting with slow fire for 20 min, and filtering to obtain medicinal liquid; mixing the first decoction and the second decoction.
The administration mode is as follows: orally administered 1 dose per day, mixing the two decoctions, and warm-taking 200ml each time in the morning and evening for 15 days as a treatment course.
Clinical examples:
a certain amount of Wei, male, 41 years old, prevent urban city people, rheumatoid arthritis for 5 years, joint swelling and pain symptom get better after continuously taking for 3 courses of treatment.
After taking certain yellow wine for 3 courses of treatment continuously, female, 49 years old, Wen' an county and 2 years old rheumatoid arthritis, the symptoms of the joint swelling and pain can be cured.
Example 2:
a Zhuang medicine composition for treating rheumatoid arthritis comprises the following raw material components: 35g of rhizoma polygoni multiflori, 35g of paederia scandens, 30g of tinospora sinensis, 20g of radix stephaniae tetrandrae, 25g of leprosum, 30g of divaricate saposhnikovia root, 25g of caulis sinomenii, 20g of rhizoma drynariae, 20g of lemongrass and 20g of whiteflower leadword root. Weighing the raw materials according to weight, respectively selecting the raw materials, pouring the raw materials into a medicine pot, and adding water to soak for 1 hour; decocting for the first time: decocting with strong fire until the decoction is boiling, decocting with slow fire for 25 min, and filtering to obtain filtrate; decocting for the second time: adding water at normal temperature into the pot until the water is 0.5 cm higher than the medicinal material plane, decocting with strong fire until boiling, decocting with slow fire for 20 min, and filtering to obtain medicinal liquid; mixing the first decoction and the second decoction.
The administration mode is as follows: the same as in example 1.
Clinical examples:
after taking certain other people, male, 46 years old, Pinnan county and 6 years old, the symptoms of the joint stiffness are improved after continuously taking the medicine for 6 treatment courses.
After taking a certain tooth, a woman in 50 years old, Xingan county and rheumatoid arthritis for 2 years, the joint stiffness symptom disappears after 4 treatment courses of continuous taking.
Example 3:
a Zhuang medicine composition for treating rheumatoid arthritis comprises the following raw material components: 30g of bunchy knotweed, 30g of Chinese fevervine herb, 30g of tinospora sinensis, 40g of Chinese wingless twig and leaf, 30g of lephanous rheumatism, 25g of divaricate saposhnikovia root, 15g of cowherb, 20g of rhizoma drynariae, 15g of lemongrass herb and 10g of whiteflower leadword root. Weighing the raw materials according to weight, respectively selecting the raw materials, pouring the raw materials into a medicine pot, and adding water to soak for 1 hour; decocting for the first time: decocting with strong fire until the decoction is boiling, decocting with slow fire for 25 min, and filtering to obtain filtrate; decocting for the second time: adding water at normal temperature into the pot until the water is 0.5 cm higher than the medicinal material plane, decocting with strong fire until boiling, decocting with slow fire for 20 min, and filtering to obtain medicinal liquid; mixing the first decoction and the second decoction.
The administration mode is as follows: the same as in example 1.
Clinical examples:
after taking Mongolian medicine, male, 48 years old, Shanglin county and 4 years old for 6 continuous courses of treatment, the symptoms of swelling and pain of joints and stiffness are obviously improved.
Xue Yi (a certain Chinese schroer) for women, 52 years old, apple county, and 4 years old, after continuously taking for 6 courses, the symptoms of joint swelling and stiffness are basically relieved.
The following are clinical statistics of patients using the inventive drugs:
1 basic data
The patients to be treated in hospitals were collected and were diagnosed with rheumatoid arthritis according to the revised standard for rheumatoid arthritis proposed by the American College for Rheumatology (ACR) in 1987. The bed shows that: 1. morning stiffness lasted at least 1 hour. 2. There is soft tissue swelling (arthritis) in 3 or more joint sites. 3. The metacarpophalangeal, proximal interphalangeal or wrist joints swell for more than 6 or 12 weeks. 4. Symmetric swelling (arthritis), i.e., the onset of the same joint on both sides of the body, either simultaneously or sequentially. 5. The X-ray film shows that the cartilage surface of the hand and/or the wrist joint is erosive and the bone around the joint is sparse and changed. 6. The patients with positive rheumatoid factor are grouped into 240 cases, wherein 125 cases of men and 115 cases of women are in the group, the age is 35-70 years, and the illness state is 3-10 years.
2 experimental grouping
Patients were randomized into 3 groups, including treatment group 1, treatment group 2, control group, 80 per group.
3 treatment regimen
The treatment group 1 adopts the medicine and the treatment method of the embodiment 1, one dose is taken every day for 2 times, and 1 treatment course comprises 15 days; the treatment group 2 adopts the medicine and the treatment method of the embodiment 2, one dose is taken every day for 2 times, and 1 treatment course is taken for 15 days; control group: the Chinese patent medicine Xiaohuoluo pills are taken orally 1 pill each time and twice a day with warm boiled water. A treatment course is 15 days. 4 courses of treatment were observed for both the treatment group and the control group.
4 determination of therapeutic Effect
The evaluation standard of the curative effect of the rheumatoid arthritis is drawn up as the cure: the joint stiffness, swelling and pain and clinical signs disappear, and the joint stiffness, swelling and pain and clinical signs disappear and do not attack for more than two years; the method has the following advantages: joint stiffness and swelling and pain are reduced; the disease is not cured: no obvious change in symptoms.
5 statistical treatment
SPSS20.0 statistical software is adopted for analysis, chi-square test is adopted for counting data, and t test is adopted for metering data. Differences of P <0.05 were statistically significant.
6 results of the experiment
The treatment group 1 has 63 cured cases, 10 effective cases and 7 ineffective cases, and the total effective rate is 91.25%; the treatment group 2 has 53 cured cases, 21 effective cases and 6 ineffective cases, and the total effective rate is 92.5 percent; the control group has 50 cured cases, 14 effective cases and 16 ineffective cases, and the total effective rate is 80 percent. The differences were statistically significant in the treated groups compared to the control group. The clinical curative effect of the treatment group is better than that of the control group.
TABLE 1 comparison of clinical efficacy of control and treatment groups
Group of Number of cases (n) Cure of disease Is effective Invalidation Total effective rate (%)
Control group 80 50 14 16 80
Treatment group 1 80 63 10 7 91.25*
Treatment group 2 80 53 21 6 92.5*
Note: p <0.05 compared to control.

Claims (1)

1. The Zhuang medicine composition for treating rheumatoid arthritis is characterized by being prepared from the following raw materials in parts by weight: 30g of bunchy knotweed, 30g of Chinese fevervine herb, 30g of tinospora sinensis, 40g of Chinese wingless twig and leaf, 30g of lephanous rheumatism, 25g of divaricate saposhnikovia root, 15g of cowherb, 20g of rhizoma drynariae, 15g of lemongrass herb and 10g of whiteflower leadword root.
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CN103272064A (en) * 2013-06-17 2013-09-04 贵州鸿德中药开发有限公司 Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine
CN104096142A (en) * 2014-07-16 2014-10-15 刘斌 Medicine for treating arthritis and arthralgia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272064A (en) * 2013-06-17 2013-09-04 贵州鸿德中药开发有限公司 Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine
CN104096142A (en) * 2014-07-16 2014-10-15 刘斌 Medicine for treating arthritis and arthralgia

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