CN105497448A - 一种用于治疗乳腺癌的中药制剂及制备方法 - Google Patents
一种用于治疗乳腺癌的中药制剂及制备方法 Download PDFInfo
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- CN105497448A CN105497448A CN201610094202.6A CN201610094202A CN105497448A CN 105497448 A CN105497448 A CN 105497448A CN 201610094202 A CN201610094202 A CN 201610094202A CN 105497448 A CN105497448 A CN 105497448A
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Abstract
本发明公开了一种用于治疗乳腺癌的中药制剂及制备方法,属中药领域;本发明中药制剂有效成分的原料组成为:抱树莲、冬凌草、石蝉草、菝葜、花生衣、了哥王、漏芦、鹿角、牡荆叶、土贝母、通光散、缬草、猕猴桃、徐长卿、拔毒散和钩吻;本发明中药制剂所选药材配伍相宜,符合中医药和现代医药理论,具有清热解毒、散结止痛、调经活血、抗癌消肿之功效,使用方便,吸收效果好,无不良及毒副作用,经临床验证,对治疗乳腺癌有极好的缓解及治疗效果,适于乳腺癌的临床治疗与护理推广应用。
Description
所属技术领域
本发明涉及中药领域,尤其涉及一种用于治疗乳腺癌的中药制剂及制备方法。
背景技术
女性乳腺是由皮肤、纤维组织、乳腺腺体和脂肪组成的,乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤。乳腺癌中99%发生在女性,男性仅占1%。
乳腺癌主要症状为:
1.乳腺肿块。80%的乳腺癌患者以乳腺肿块首诊。患者常无意中发现乳腺肿块,多为单发,质硬,边缘不规则,表面欠光滑。大多数乳腺癌为无痛性肿块,仅少数伴有不同程度的隐痛或刺痛。
2.***溢液。非妊娠期从***流出血液、浆液、乳汁、脓液,或停止哺乳半年以上仍有乳汁流出者,称为***溢液。
3.皮肤改变。乳腺癌引起皮肤改变可出现多种体征,最常见的是肿瘤侵犯了连接乳腺皮肤和深层胸肌筋膜的Cooper韧带,使其缩短并失去弹性,牵拉相应部位的皮肤,出现“酒窝征”,即乳腺皮肤出现一个小凹陷,像小酒窝一样。若癌细胞阻塞了***,则会出现“橘皮样改变”,即乳腺皮肤出现许多小点状凹陷,就像橘子皮一样。乳腺癌晚期,癌细胞沿***、腺管或纤维组织浸润到皮内并生长,在主癌灶周围的皮肤形成散在分布的质硬结节,即所谓“皮肤卫星结节”。
4.***、乳晕异常。肿瘤位于或接近***深部,可引起***回缩。肿瘤距***较远,乳腺内的大导管受到侵犯而短缩时,也可引起***回缩或抬高。
5.腋窝***肿。初期可出现同侧腋窝***肿大,肿大的***质硬、散在、可推动。随着病情发展,***逐渐融合,并与皮肤和周围组织粘连、固定。晚期可在锁骨上和对侧腋窝摸到转移的***。
虽然乳腺并不是维持人体生命活动的重要器官,原位乳腺癌并不致命,但由于乳腺癌细胞丧失了正常细胞的特性,细胞之间连接松散,容易脱落。癌细胞一旦脱落,游离的癌细胞可以随血液或淋巴液播散全身,形成转移,危及生命,严重威胁女性身心健康的常见肿瘤。目前用于治疗乳腺癌的方法有手术、放疗、化疗、内分泌治疗、生物靶向治疗,但治疗后需要药物辅助治疗。而中药学作为我国的传统医学,具有作用强、见效快、药效持久等优点,且没有依赖性、耐药性以及毒副作用,因此选择一种中药制剂用于治疗乳腺癌,对于治疗乳腺癌具有十分重要的临床意义。
发明内容
本发明提供了一种用于治疗乳腺癌的中药制剂及制备方法;本发明中药制剂所选药材配伍相宜,符合中医药和现代医药理论,具有清热解毒、散结止痛、调经活血、抗癌消肿之功效,使用方便,吸收效果好,无不良及毒副作用,经临床验证,对治疗乳腺癌有极好的缓解及治疗效果,适于乳腺癌的临床治疗与护理推广应用。
为实现上述目的,本发明的技术方案实施如下:
一种用于治疗乳腺癌的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
一种用于治疗乳腺癌的中药制剂的制备方法,包括以下工艺步骤:
(1)将抱树莲、花生衣、了哥王、牡荆叶、土贝母、猕猴桃、拔毒散和钩吻去除杂质,洗净,放入容器中,加蒸馏水浸泡3小时,后加5倍量蒸馏水,煎煮2小时,提取煎煮液;再加入3~4倍量蒸馏水,煎煮1.5小时,提取煎煮液,最后合并2次提取的煎煮液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(2)将冬凌草、石蝉草、缬草和徐长卿去除杂质,洗净,日晒干燥,置于容器内捣碎研末,得到过120目的细粉,备用;
(3)将菝葜、漏芦和通光散去除杂质,洗净,放入容器内,用盐水浸泡10个小时后蒸熟,切片晒干,置于容器内捣碎研末,得到过140目的细粉,备用;
(4)将鹿角洗净,放入容器内,后加入白蜜漫过,微火熬令小变色,暴干,置于容器内捣碎研末,得到过160目的细粉,备用。
(5)将步骤(1)所得的稠膏与步骤(2)、步骤(3)、步骤(4)所得的细粉混合后制成片剂,即为所述的用于治疗乳腺癌的中药制剂。
本发明所用中药的药性如下:
抱树莲:味甘、淡,性凉;归肝、肺经。清热解毒,止血消肿。用于黄疸,***结核,腮腺炎,肺结核咯血,血崩,乳腺癌,跌打损伤。《常用中草药手册》载:“消炎解毒,祛风止咳。治黄疸,淋巴腺结核,腮腺炎,咳嗽咳血,风湿骨痛,乳癌,大便燥结。”
冬凌草:味苦、甘,性微寒。清热解毒,活血止痛。用于咽喉肿痛,感冒头痛,气管炎,慢性肝炎,风湿关节痛,蛇虫咬伤。
石蝉草:味辛,性凉;归肺、脾、肝、肾经。清热解毒,化瘀散结,利水消肿。用于肺热咳喘,麻疹疮毒,癌肿,烧烫伤,跌打损伤,肾炎水肿。《云南中草药选》载:“祛瘀散结,抗癌。治胃癌,食道癌,肝癌,乳腺癌,肺癌。”
菝葜:味甘、酸,性平;归脾、胃、肺经。祛风利湿,解毒消肿。用于风湿关节痛,跌打损伤,胃肠炎,消化不良,糖尿病,乳糜尿,白带,癌症,痈疖疔疮,烫伤。《品汇精要》载:“散肿毒。”
花生衣:味甘、微苦,涩,性平。止血,散瘀,消肿。用于血友病、类血友病,原发性及继发性血小板减少性紫癜,肝病出血症,术后出血,癌肿出血,胃、肠、肺、子宫等出血。
了哥王:味苦、微辛,性寒。清热解毒,化痰散结,通经利水。扁桃体炎,腮腺炎,***炎,支气管炎,哮喘肺炎,跌打损伤,水肿,急性乳腺炎,蜂窝织炎。《岭南采药录》载:“叶和盐捣烂外敷。能去皮肤红黑瘀血,拔毒消肿。”
漏芦:味苦,性寒;归胃经。清热解毒,消痈下乳,舒筋通脉。用于乳痈肿痛,痈疽发背,瘰疬疮毒,乳汁不通,湿痹拘挛。《日华子本草》载:“治小儿壮热,通小肠,(治)泄精,尿血,风赤眼,乳痈,发背,瘰疬,肠风,排脓,补血,治扑损,续筋骨,敷金疮,止血长肉,通经脉。”
鹿角:味咸,性温;归肝、肾经。温肾阳,强筋骨,行血消肿。用于阳痿遗精,腰脊冷痛,阴疽疮疡,乳痈初起,瘀血肿痛。《本经》载:“主恶疮痈肿,逐邪恶气,留血在阴中。”
牡荆叶:味微苦、辛,性平;归肺经。祛风解表,除湿杀虫,止痛。用于风寒感冒,痧气腹痛吐泻,痢疾,风湿痛,脚气流火,痈肿足癣。《福建中草药》载:“祛风解表,调气和胃。”
土贝母:味苦,性微寒;归肺、脾经。散结,消肿,解毒。用于乳痈,瘰疬,乳腺炎,颈***结核,慢性***炎,肥厚性鼻炎。《陕西中草药》载:“清热解毒消肿。治淋巴腺结核,急性乳腺炎初起,痈肿。”
通光散:味苦,性寒。止咳平喘,通乳利尿,抗癌。用于上呼吸道感染,支气管炎,支气管哮喘,乳汁不通,小便不利,癌肿,痈疖疮疡。《云南中草药选》载:“消炎,止咳,平喘,抗癌。治支气管炎,支气管哮喘,各种癌症,风湿,跌打,骨折,眼底疾患,胃病。”
缬草:味辛、甘,性温;归肺、脾经。安神,理气,止痛。用于神经衰弱失眠,癔病癫痫,胃腹胀痛,腰腿痛,跌打损伤。《陕西中草药》载:“安神镇静,驱风解痉,生肌止血,止痛。治癔病,克山病,心脏病,腰腿痛,胃肠痉挛,关节炎,跌打损伤,外伤出血。”
猕猴桃:味甘、涩,性寒。清热解毒,活血消肿,祛风利湿。用于风湿性关节炎,跌打损伤,丝虫病,肝炎痢疾,***结核,痈疖肿毒,癌症。《开宝本草》载:“止暴渴,解烦热,下石淋。热壅反胃者,取汁和生姜汁服之。”
徐长卿:味辛,性温。镇痛止咳,利水消肿,活血解毒。用于胃痛牙痛,风湿疼痛,经期腹痛,慢性气管炎,腹水水肿,痢疾肠炎,跌打损伤,湿疹,荨麻疹,毒蛇咬伤。《常用中草药手册》载:“祛风止痛,解毒消肿,温经通络。治毒蛇咬伤,风湿骨痛,心胃气痛,跌打肿痛,带状疱疹,肝硬化腹水,***,痛经。”
拔毒散:味苦,性平。调经通乳,解毒消肿。用于闭经,乳汁不通,乳腺炎,肠炎,痢疾,治跌打损伤,痈肿。《云南中草药选》载:“消炎,拔毒生肌。治急性乳腺炎,急性扁桃体炎,肠炎,菌痢。”
钩吻:味辛、苦,性温,有毒。祛风攻毒,消肿止痛。用于疥癞湿疹,瘰疬痈肿,疔疮,跌打损伤,风湿痹痛,神经痛。《本经》载:“主金疮,乳痓,中恶风,咳逆上气,水肿。”
本发明与现有技术相比,具有以下有益效果:
本发明中药制剂所选药材配伍相宜,符合中医药和现代医药理论,具有清热解毒、散结止痛、调经活血、抗癌消肿之功效,使用方便,吸收效果好,无不良及毒副作用,经临床验证,对治疗乳腺癌有极好的缓解及治疗效果,适于乳腺癌的临床治疗与护理推广应用。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明中药制剂有效成分的原料组成及重量为:
本发明中药制剂制备方法的工艺步骤为:
(1)将抱树莲、花生衣、了哥王、牡荆叶、土贝母、猕猴桃、拔毒散和钩吻去除杂质,洗净,放入容器中,加蒸馏水浸泡3小时,后加5倍量蒸馏水,煎煮2小时,提取煎煮液;再加入3~4倍量蒸馏水,煎煮1.5小时,提取煎煮液,最后合并2次提取的煎煮液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(2)将冬凌草、石蝉草、缬草和徐长卿去除杂质,洗净,日晒干燥,置于容器内捣碎研末,得到过120目的细粉,备用;
(3)将菝葜、漏芦和通光散去除杂质,洗净,放入容器内,用盐水浸泡10个小时后蒸熟,切片晒干,置于容器内捣碎研末,得到过140目的细粉,备用;
(4)将鹿角洗净,放入容器内,后加入白蜜漫过,微火熬令小变色,暴干,置于容器内捣碎研末,得到过160目的细粉,备用。
(5)将步骤(1)所得的稠膏与步骤(2)、步骤(3)、步骤(4)所得的细粉混合后制成片剂,即为所述的用于治疗乳腺癌的中药制剂。
用法用量:口服,每日3次,早中晚各一次,每次2片,15天为一个疗程,通常1~3个疗程痊愈,严重者遵医嘱酌增用量。
实施例2
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
实施例3
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
实施例4
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
临床资料:
1、病例选择:
选择我院或外院确诊的乳腺癌患者480例临床观察,病人随机分成两组,治疗组240例,年龄38~62岁,平均年龄40岁,病程2个月~1年,平均6个月。对照组240例,年龄40~60岁,平均年龄42岁,病程1个月~6个月,平均3个月。两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2、药物选择:
治疗组患者服用本中药制剂,口服,每日3次,早中晚各一次,每次2片,15天为一个疗程,连续服用1~3个疗程,严重者遵医嘱酌增用量。
对照组服用醋酸甲羟孕酮片,口服,一次100mg(50片),一日3次,或口服500mg(250片),每日1-2次。
3、疗效判定:
(1)治愈:乳腺隐痛、***发炎、腋下淋巴肿大等症状消失;疼痛消失,身体痊愈。
(2)有效:上述症状有所缓解,疼痛消失,身体痊愈。
(3)无效:病症无变化。
4、结果:
服用本发明药物的治疗组中,治愈190例,有效40例,无效10例,治愈率79.2%,总有效率95.8%。
对照组中治愈100例,有效88例,无效52例,治愈率41.7%,总有效率78.3%。
以上结果显示,治疗组治愈率和总有效率明显高于对照组。
典型病例举例:
1、宁××,女,39岁,商场职工,北京朝阳区。患者一年前左乳发现一质硬无痛性肿块,轻微活动,未予以重视。后肿块渐大、渐硬,***内陷并固定。经我院检查后被确诊为乳腺癌。术后服用本发明中药制剂1个疗程后,症状明显缓解,继续服用1个疗程,临床症状全部消失。随访至今未复发。
2、杨××,女,41岁,自由职业,江西上饶人。患者患有右乳腺癌,肿瘤直径约1.8cm。术后服用本发明中药制剂1个疗程后,身体逐渐康复,症状明显缓解,继续服用2个疗程,以上症状消失。随访至今未复发。
3、左××,女,42岁,私营业主,辽宁大连人。患者有乳腺肿块,质硬,边缘不规则,表面不光滑,并伴有隐痛感。经我院检查被确诊为乳腺癌。服用本发明中药制剂2个疗程后,症状明显好转,继续服用1个疗程后,以上症状消失,身体恢复健康。随访至今未复发。
4、孙××,女,46岁,经理,福建龙岩人。患者患有乳腺癌,***回缩,乳腺皮肤出现一个小凹陷,像小酒窝一样。术后服用本发明中药制剂1个疗程症状明显缓解,继续服用1个疗程后,症状消失。随访没有复发。
5、谢××,女,51岁,农民,安徽铜陵人。患者乳腺肿块,质硬,***、乳晕异常,腋窝处***肿大。服用本发明中药制剂2个疗程后,以上症状好转,继续服用2个疗程后,以上症状消失,身体痊愈,恢复健康。随访至今未复发。
6、何××,女,55岁,农民,河北廊坊人。患者已绝经,近期左乳皮肤红、肿、热、痛,左***可挤出少量褐色液体,遂来我院检查,被诊断为乳腺癌。服用本发明中药制剂1个疗程后,症状好转,继而服用2个疗程后,身体恢复正常,***正常。随访至今未复发。
Claims (5)
1.一种用于治疗乳腺癌的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
抱树莲52~82份冬凌草49~79份石蝉草47~77份菝葜45~75份
花生衣42~72份了哥王37~67份漏芦34~64份鹿角32~62份
牡荆叶30~60份土贝母27~57份通光散25~55份缬草23~53份
猕猴桃22~52份徐长卿18~48份拔毒散17~47份钩吻12~42份。
2.一种用于治疗乳腺癌的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
抱树莲75份冬凌草72份石蝉草70份菝葜68份
花生衣65份了哥王60份漏芦58份鹿角56份
牡荆叶54份土贝母50份通光散48份缬草46份
猕猴桃45份徐长卿41份拔毒散40份钩吻35份。
3.一种用于治疗乳腺癌的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
抱树莲68份冬凌草65份石蝉草63份菝葜61份
花生衣58份了哥王53份漏芦51份鹿角48份
牡荆叶47份土贝母43份通光散41份缬草39份
猕猴桃38份徐长卿34份拔毒散33份钩吻28份。
4.一种用于治疗乳腺癌的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
抱树莲60份冬凌草56份石蝉草55份菝葜54份
花生衣50份了哥王45份漏芦42份鹿角41份
牡荆叶36份土贝母35份通光散34份缬草31份
猕猴桃30份徐长卿26份拔毒散25份钩吻20份。
5.一种如权利要求1~4任一项所述的用于治疗乳腺癌的中药制剂的制备方法,其特征在于:包括以下工艺步骤:
(1)将抱树莲、花生衣、了哥王、牡荆叶、土贝母、猕猴桃、拔毒散和钩吻去除杂质,洗净,放入容器中,加蒸馏水浸泡3小时,后加5倍量蒸馏水,煎煮2小时,提取煎煮液;再加入3~4倍量蒸馏水,煎煮1.5小时,提取煎煮液,最后合并2次提取的煎煮液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(2)将冬凌草、石蝉草、缬草和徐长卿去除杂质,洗净,日晒干燥,置于容器内捣碎研末,得到过120目的细粉,备用;
(3)将菝葜、漏芦和通光散去除杂质,洗净,放入容器内,用盐水浸泡10个小时后蒸熟,切片晒干,置于容器内捣碎研末,得到过140目的细粉,备用;
(4)将鹿角洗净,放入容器内,后加入白蜜漫过,微火熬令小变色,暴干,置于容器内捣碎研末,得到过160目的细粉,备用;
(5)将步骤(1)所得的稠膏与步骤(2)、步骤(3)、步骤(4)所得的细粉混合后制成片剂,即为所述的用于治疗乳腺癌的中药制剂。
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CN106822666A (zh) * | 2017-04-13 | 2017-06-13 | 李桂兰 | 一种用于治疗乳腺癌的药物及其制备方法和应用 |
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CN106822666A (zh) * | 2017-04-13 | 2017-06-13 | 李桂兰 | 一种用于治疗乳腺癌的药物及其制备方法和应用 |
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