CN105496886B - Phytosphingosine shin moisturizer - Google Patents
Phytosphingosine shin moisturizer Download PDFInfo
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- CN105496886B CN105496886B CN201511007853.9A CN201511007853A CN105496886B CN 105496886 B CN105496886 B CN 105496886B CN 201511007853 A CN201511007853 A CN 201511007853A CN 105496886 B CN105496886 B CN 105496886B
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- phytosphingosine
- ceramide
- hydrolecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of skin care item, it is intended to provide a kind of phytosphingosine shin moisturizer, its key points of the technical solution are that each component is denoted as 10 ~ 12 parts of phytosphingosine in parts by weight in the formula, 8 ~ 10 parts of ceramide, 5 ~ 7 parts of cholesterine, 8 ~ 11 parts of hydrolecithin, 14 ~ 17 parts of phosphoric acid components, 22 ~ 24 parts of nutritional ingredient, 60 ~ 80 parts of deionized water.The advantage of the invention is that obtaining the effect of repair cell and moisturizing by addition phytosphingosine and ceramide, and it is added to the phosphatide similar with skin lipid structure, improve the penetrating power of phytosphingosine and ceramide on the skin, furthermore, addition cholesterine and hydrolecithin are prepared for nano liposomes, phytosphingosine and ceramide are improved to the compatibility of oily phase, assimilation effect is more preferable.
Description
Technical field
The present invention relates to a kind of skin care item, more specifically, it relates to a kind of phytosphingosine shin moisturizer.
Background technique
Skin care has become a Men Xuewen in the modern times, and people are no longer blindly gone shopping by skin problem puzzlement and buy variousization
Cosmetic is tried, but outputs prescription by dermatologist, provides targetedly skin care suggestion.As people are to the pursuit day of health
The surging high speed development with dermatology of benefit, the medicine skin care item with greater security and validity have become irresistible
One trend.Start to focus on the quality and safety of skin care item with more women, professional is to skin and its attached
The structure of device and physiological action research and understanding deeper into, it is more specialized to the research of cosmetics, performance more targetedly, can
By property and competitiveness.Currently, dry, people's stress is big, and daily life system is irregular due to environmental pollution, it is metabolized disorderly
Disorderly；Improper to the nursing of skin, so that skin the skin problems such as many problems, such as acne, acne, blackhead is occurred just annoyings
Many people, these skin problems are all the skin injuries as caused by environmental factor and individual physiological factor.But traditional skin
Skin maintenance and maintenance product are added to hormonal components mostly, and What is more can add micro mercury in the product, and the short time uses
Skin quality and the colour of skin can actually be obviously improved these products on the surface, and skin seems that children is white and soft, but this nothing
Different from drinking poison to quench thirst, these skin-protection products are used for a long time can cause the damage of unrepairable to skin.The purpose of skin-protection product is
Skin repair is remained into its normal physiological condition to or by skin.Place is had already appeared in damage, skin care item should not be right
Cutaneous lesion only carries out the covering with paint on surface, but the Natural re generation ability of skin should be replied by deep layer, i.e., from
The skin corium of the cuticula of upper layers of skin to lining is all soaked and is protected, therefore should restore the permeability of skin barrier layer
Can, and add the update for promoting skin with nutriment needed for skin.On the basis of maintenance skin, then assist to have
Whitening, moisturizing, Firm and the functions such as anti-oxidant additive, it will be able to good beautification and repairing effect are played to skin.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of affine skin and being capable of deep layer maintenance
The shin moisturizer of skin.
To achieve the above object, the present invention provides the following technical scheme that a kind of phytosphingosine shin moisturizer, feature
Be: each component is denoted as in parts by weight in the formula
10 ~ 12 parts of phytosphingosine
8 ~ 10 parts of ceramide
5 ~ 7 parts of cholesterine
8 ~ 11 parts of hydrolecithin
14 ~ 17 parts of phosphoric acid components
22 ~ 24 parts of nutritional ingredient
60 ~ 80 parts of deionized water.
Plant sheath propylhomoserin is connect by ester bond with cell cortex protein and plays bonding cytosis, this mutual
System is referred to as " one cell of lipid, one protein " wrappage, and the reduction of plant sheath histidine content can make keratinocyte in horny layer of epidermis
It asks that adhesion strength declines, leads to dry skin, furfur, in flakey, ceramide has hydrone ability of associating by force very much, it passes through
Reticular structure is formed in cuticula and maintains moisture of skin, and therefore, ceramide, which has, keeps moisture of skin effect, using containing mind
Skin-active essence cosmetics through amide, can reinforce skin anti-aging function, and skin is enabled to keep elasticity, smooth careful, reduce face
Wrinkle is formed, and since skin has certain barrier action, phytosphingosine and ceramide are difficult to permeate wherein, therefore here
It is added to phospholipid composition, phosphatide is the most similar lipid of lipid layer structure with skin, can make phytosphingosine and nerve
Amide more honor penetrates into skin, while also added cholesterine and hydrolecithin in the component nano-lipid is made
Body, phytosphingosine and ceramide are wrapped in be in lipophilic excellent liposome be easier to be less readily available for absorption by the skin.
Preferably, the phospholipid fraction is one of olive oil and sunflower oil.
Olive oil and sunflower oil are structure and the most similar phosphatide of skin phosphatide, the phosphorus of here as affine skin
Rouge component bring osmotic effect is best.
Preferably, the nutritional ingredient is collagen component, antioxidant composition and moisturizing component.
Addition nutritional ingredient is to improve the shin moisturizer to the maintenance action of skin, and adding collagen component facilitates
Skin elasticity is improved, to promote skin more compact；Addition antioxidant composition is then the degree of aging in order to slow down skin, is risen
To the effect for freezing face beauty treatment；Addition moisturizing component is then in order to keep humidity of skin, so that skin more water profit children is sliding.
Preferably, the collagen component is the composition of Type I collagen albumen and V collagen type.
Type I collagen most significant feature in fish collagen is that thermal stability is relatively low, and presents fingerling
Specificity has good skin tightening effect；Usual V collagen type of middle finger of pericellular collagen is protected in the deep layer maintenance
V collagen type is added in skin liquid can effectively improve structural strength between Skin Cell, so as to improve skin
Compactness.
Preferably, the antioxidant composition is the composition of procyanidine and pearl powder.
Procyanidine is the general name for the major class polyphenolic substance being widely present in plant, have it is extremely strong it is anti-oxidant, disappear
Except the effect of free radical, ultra-oxygen anion free radical and hydroxyl radical free radical can be effectively eliminated, also assists in phosphoric acid, arachidonic
Metabolism and protein phosphorylation, protect lipid that peroxide injury does not occur, and cooperation α-bisabolol use can repair skin
While anti-aging protection is applied to skin, high poly- procyanidine can also be moisturized the skin effectively, improve skin elasticity and
Flatness, glucosidase procyanidins then can improve skin to the absorbability of nutriment in conjunction with many nutriments；Pearl
Powder is a kind of traditional skin care whitening product, has good antioxygenic property, can effectively remove oneself for leading to aging in skin
By base, free radical is the important priming factors of aging, and with advancing age, metabolism gradually slows down, itself is resisted freely
The phenomenon that therefore ability of base can reduce, skin and organ just will appear aging ahead of time.What pearl powder itself contained
Three kinds of microelements such as manganese, copper, zinc are that the ingredient of composition SOD can promote human skin superoxide dismutase with pearl powder coating surface
The activity of enzyme inhibits the synthesis of melanin, keeps whitening skin.
Preferably, the moisturizing group is divided into the composition of protein hydrolysate and chondroitin sulfate.
Protein hydrolysate costly, can not only play good moisture-keeping function, additionally it is possible to required egg is provided for skin
White matter, to help to improve skin vitality；Chondroitin sulfate has protective effect to cornea collagenous fibres, can promote in matrix
The growth of fiber enhances permeability, improves blood circulation, accelerates metabolism, promotes the absorption of penetrating fluid and the elimination of inflammation；
Its polyanion has strong water-retaining property, can improve the water metabolism of skin histology, have stronger affinity to skin, can be in skin
Skin surface forms one layer of ventilative water-retaining film, improves eye dryness symptom.
Compared with prior art, the invention has the benefit that plant sheath propylhomoserin and cell cortex protein pass through ester bond
Bonding cytosis is played in connection, and this mutual connection is referred to as " one cell of lipid, one protein " wrappage, epidermis angle
The reduction of plant sheath histidine content can make keratinocyte ask that adhesion strength declines in matter layer, lead to dry skin, furfur, be in flakey,
Ceramide has hydrone ability of associating by force very much, it maintains moisture of skin by forming reticular structure in cuticula, therefore,
Ceramide, which has, keeps moisture of skin effect that can reinforce skin anti-aging using the skin-active essence cosmetics containing ceramide
Function enables skin keep elasticity, smooth careful, reduces facial wrinkles and is formed, since skin has certain barrier action, plant
Sphingol and ceramide are difficult to permeate wherein, therefore are added to phospholipid composition here, and phosphatide is the lipid layer structure with skin
The most similar lipid can be such that phytosphingosine and ceramide more honor penetrates into skin, while also add in the component
Add cholesterine and hydrolecithin that nano liposomes are made, phytosphingosine and ceramide has been wrapped in lipophilic excellent
Liposome in be be easier to be less readily available for absorption by the skin.
Specific embodiment
Embodiment 1
12 parts of phytosphingosine
0 part of Cer EOS
7 parts of cholesterine
11 parts of hydrolecithin
17 parts of olive oil
4 parts of Type I collagen albumen
V 3 parts of collagen type
4 parts of procyanidine
5 parts of pearl powder
5 parts of protein hydrolysate
3 parts of chondroitin sulfate
80 parts of deionized water
Embodiment 2
10 parts of phytosphingosine
8 parts of ceramide
5 parts of cholesterine
8 parts of hydrolecithin
14 parts of sunflower oil
3 parts of Type I collagen albumen
V 3 parts of collagen type
4 parts of procyanidine
4 parts of pearl powder
4 parts of protein hydrolysate
4 parts of chondroitin sulfate
60 parts of deionized water
Embodiment 3
11 parts of phytosphingosine
8.9 parts of ceramide
6.2 parts of cholesterine
9.5 parts of hydrolecithin
16 parts of olive oil
3 parts of Type I collagen albumen
V 3 parts of collagen type
5 parts of procyanidine
4 parts of pearl powder
4 parts of protein hydrolysate
4 parts of chondroitin sulfate
69 parts of deionized water
Comparative example 1
11.2 parts of phytosphingosine
8.9 parts of ceramide
6.2 parts of cholesterine
10 parts of hydrolecithin
3 parts of Type I collagen albumen
V 3.2 parts of collagen type
5 parts of procyanidine
4 parts of pearl powder
3.5 parts of protein hydrolysate
4 parts of chondroitin sulfate
69 parts of deionized water
Comparative example 2
10.8 parts of phytosphingosine
.2 parts of Cer EOP
15.8 parts of olive oil
4 parts of Type I collagen albumen
V 3 parts of collagen type
4 parts of procyanidine
4 parts of pearl powder
4.2 parts of protein hydrolysate
4 parts of chondroitin sulfate
75 parts of deionized water
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Properties of product test
It carries out ultraviolet light simulation sun burn using hairless mouse of the ultraviolet light to identical physique and health status to handle, so
The surface of a wound of mouse is smeared respectively with according to product made from three groups of embodiments and two groups of comparative examples respectively afterwards, observes mouse
Healing time, it has been observed that healing time is ordered as 2 > comparative example of embodiment 1 > embodiment, 3 > embodiment 2 from long to short with this
> comparative example 1, it is possible thereby to clearly judge the formula maintenance effect and plant sheath propylhomoserin and ceramide concentration in just
Than, it may thus be appreciated that plant sheath propylhomoserin and ceramide are main functional component, while maintenance effect also with whether add phosphatide and
Liposome is related, and the influence by the visible phosphatide of experimental result to assimilation effect is greater than liposome.
Claims (1)
1. a kind of phytosphingosine shin moisturizer, it is characterized in that: each component is denoted as in parts by weight in the formula,
10 parts of phytosphingosine
8 parts of ceramide
5 parts of cholesterine
8 parts of hydrolecithin
14 parts of sunflower oil
3 parts of I-type collagen
3 parts of collagen type v albumen
4 parts of procyanidine
4 parts of pearl powder
4 parts of protein hydrolysate
4 parts of chondroitin sulfate
60 parts of deionized water；
Cholesterine and hydrolecithin have been added in the component nano liposomes are made, by plant sheath amine alcohol and ceramide packet
It is rolled in lipophilic excellent nano liposomes and is allowed to be easier to be absorbed by the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007853.9A CN105496886B (en) | 2015-12-29 | 2015-12-29 | Phytosphingosine shin moisturizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007853.9A CN105496886B (en) | 2015-12-29 | 2015-12-29 | Phytosphingosine shin moisturizer |
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| Publication Number | Publication Date |
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| CN105496886A CN105496886A (en) | 2016-04-20 |
| CN105496886B true CN105496886B (en) | 2019-06-25 |
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| CN201511007853.9A Active CN105496886B (en) | 2015-12-29 | 2015-12-29 | Phytosphingosine shin moisturizer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106389168B (en) * | 2016-11-14 | 2019-08-16 | 吉林大学 | With the oil-in-water nanometer creams and preparation method that whitening effect is positively charged |
| CN109875910A (en) * | 2019-04-19 | 2019-06-14 | 武汉百思凯瑞生物科技有限公司 | A kind of complex polypeptide nano vesicle and its preparation method and application with skin repair function |
| CN111603423A (en) * | 2020-07-14 | 2020-09-01 | 泉后(广州)生物科技研究院有限公司 | Anti-dandruff composition and preparation method and application thereof |
| CN112336649B (en) * | 2020-11-09 | 2021-10-22 | 江南大学 | Preparation method and product of skin co-permeation carrier of ceramide and fat-soluble active substance |
| CN112315882B (en) * | 2020-11-23 | 2021-05-28 | 山东福瑞达生物工程有限公司 | Soothing, repairing and moisturizing cream and preparation method thereof |
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| CN1112916C (en) * | 1997-12-05 | 2003-07-02 | 科斯莫弗姆有限公司 | Composition containing free kind sphingol alkali and ceramide and its usage |
| CN104546516A (en) * | 2014-12-09 | 2015-04-29 | 美嘉乐(上海)生物科技有限公司 | Preparation process and application of compound ceramide liposome |
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