CN105495236A - Liquid composition capable of protecting gastric mucosae on basis of fermented juice of hibisus essulentus L. and preparation method - Google Patents

Liquid composition capable of protecting gastric mucosae on basis of fermented juice of hibisus essulentus L. and preparation method Download PDF

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Publication number
CN105495236A
CN105495236A CN201510936882.7A CN201510936882A CN105495236A CN 105495236 A CN105495236 A CN 105495236A CN 201510936882 A CN201510936882 A CN 201510936882A CN 105495236 A CN105495236 A CN 105495236A
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okra
fluid composition
juice
fermented juice
preparation
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严求真
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Shenzhen Wantong Green Ecological Agriculture Technology Co Ltd
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Shenzhen Wantong Green Ecological Agriculture Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A23L2/395—Dry compositions in a particular shape or form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

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  • Food Science & Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

The invention provides a liquid composition capable of protecting gastric mucosae on the basis of fermented juice of hibisus essulentus L. and a preparation method. The liquid composition is prepared from 20%-99.94% by volume of fermented sticky juice of hibisus essulentus L., 0.05%-1.5% by wight volume of seasonings, 0.01%-0.1% by weight volume of preservative and the balance water. The liquid composition is unique in mouthfeel and uniform in solute and has the health-care and curative effect of protecting the gastric mucosae.

Description

A kind of fluid composition based on okra fermented juice protection stomach lining and preparation method
Technical field
The invention belongs to Medicines and Health Product technical field, particularly a kind of fluid composition based on okra fermented juice protection stomach lining and preparation method.
Background technology
Okra (HibisusessulentusL.) has another name called swordweed, Abelmoschus esculentus, hair eggplant, for a kind of Malvaceae (Abelmoschus) Abelmoschus (Malvaceae), belong to annual herb plant, originate in Africa, also there are wild species in China.Extensively cultivate in torrid areas such as Europe Africa Middle East, India and Southeast Asia at present.The people institute heat that become okra pursues high a grade nutritive health-care vegetable, the fashionable whole world.American is called " plant gold gold autumn certain herbaceous plants with big flowers ", is the good medicine of protection stomach lining, and its edible portion is fruit pod, divides again green and red two kinds, its tender and crisp succulence, and lubricious oiliness, fragrance is unique, deeply favors by the common people.Record according to the ancient books such as Compendium of Material Medica, the root, stem, flower, seed etc. of gumbo all can be used as medicine, and its nature and flavor are sweet, cold, sliding, enter the heart, lung, kidney, stomach, liver and bladder, can control insufficiency of the spleen weak, the dry constipation of intestines and illness such as evil sore, carbuncle furuncle etc.Gumbo is the new vegetables of one occurred in recent years in the international market, and health value is very high.Often ediblely to help digest, to reduce blood fat, strengthen muscle power and the endurance of people.There are protection stomach, liver, skin and mucous membrane, strengthen the effect of skin elasticity; And it is all effective in cure to diseases such as gastritis, gastric ulcer, livers.Also has the effect strengthening physical endurance and strong kidney qi-restoratives, be described as " plant vigour " and become popular situation of selling well vegetables in Japan, Taiwan, Hong Kong and western countries, the many countries in Africa become sportsman edible first choice of vegetables, the especially health food of the elderly.Gumbo is mainly containing pectin, and glycopeptide, the nutriments such as protein, owing to wherein the absorption of carbohydrate can reach antidotal effect in control volume containing peptidoglycan is often edible.
The main component of relevant bibliographical information okra has amino acid and protein, trace element, polysaccharide, flavone compound, containing a kind of stickiness polysaccharide material be made up of pectin, cow's milk glycan and gum arabic etc. in the tender pod of gumbo.In addition, it is also containing abundant vitamin A, B, C etc.Its pharmacological action has antifatigue effect, improves immunity of organisms, reduces injury of lungs, antitumaous effect; glycoprotein containing a kind of stickiness in young fruit; often ediblely to help digest, stomach invigorating, whole intestines, protection stomach, liver and skin, mucous membrane effect, all effective in cure to diseases such as gastritis, gastric ulcer, livers.The sweet cunning of okra taste, there is invigorating spleen and reinforcing stomach, moisturize effect of sharp intestines, the diseases such as insufficiency of the spleen weak, the dry constipation of intestines can be controlled.Prior art Chinese patent CN101991620A discloses the medicament and application thereof prepared with Abelmoschus Esculentus Linn extract, is applied in the medicine for the treatment of or prevention impotence, premature ejaculation, stomach trouble, heart disease, apoplexy, skeleton bulking and Alzheimer etc.All do not relate to the effect of okra fermented juice for auxiliary protection stomach lining.
Summary of the invention
In view of the technical problem that prior art exists, an object of the present invention is to provide a kind of fluid composition based on okra fermented juice protection stomach lining.
The present invention is realized by following approach:
Based on a fluid composition for okra fermented juice protection stomach lining, the component of described fluid composition and proportioning are:
Okra fermentation mucus juice (percent by volume) 20%-99.94%;
Flavouring (percent weight in volume) 0.05%-1.5%;
Anticorrisive agent (percent weight in volume) 0.01%-0.1%;
Surplus is water.
Described flavouring is selected from one in glycine, alanine, peppermint oil, orange-seed oil or its mixture.
Described anticorrisive agent is selected from one in benzoic acid, potassium sorbate, ethyl-para-hydroxybenzoate or its mixture.
By the fluid composition that the okra acquisition fermentation mucus juice of fermentation goes out with suitable auxiliaries, its mouthfeel is unique, material is homogeneous, can protect stomach lining, has and keeps healthy and therapeutic efficiency.
The pH value of described fluid composition is 3.0 – 5.5, soluble solid content is 2.5%-12.0%.Can ensure that solution mass is homogeneous, solid content crosses that I haven't seen you for ages affects effect, and the too much solution uniformity of solid content reduces.
Further preferred described composition pH value is 3.0 – 4.5, and soluble solids content is 5.0% – 9.0%.Effect of material can be ensured, the homogeneity of solution mass can be ensured again.
Another object of the present invention is to provide described a kind of fluid composition based on okra fermented juice protection stomach lining in the application preparing health products, food or the medicine of protecting stomach lining.
Or okra fermented juice is preparing the application of the health products of protection stomach lining, food or medicine.Preferred described okra fermented juice preparation method is: the okra of maturation is placed in 23-28 DEG C of closed container and ferments 2 – 4 months, get okra fermented juice, sterilize, filter to get filtrate.
Preferably add honey to ferment, the weight ratio of honey and okra is honey: okra: water=1:3:10.
The formulation of described health products, food or medicine is preferably oral liquid.
Described soluble solid refers to all general names being dissolved in the compound of water in liquid or fluid.
Another object of the present invention is to provide a kind of method preparing the fluid composition of described okra fermented juice, comprise step:
(1) okra of maturation is placed in 23-28 DEG C of closed container to ferment 2 – 4 months, gets okra fermented juice, bus sterilization, filter to get filtrate;
(2) with adding in filtrate after water-soluble solution flavouring and anticorrisive agent;
(3) amount of preparation is settled to water.
Wherein, be preferably the nylon membrane class filter media of 10-100 μm by step (1) fermented juice filtering technique, or retain aperture 4 – 400,000 molecular weight polymeric hollow cellulose membrane with film and carry out ultrafiltration.
Filtrate after preferably step (3) being prepared is that the miillpore filter of 0.22 μ m – 0.8 μm or micropore filter element carry out micro-filtration by aperture, and preferred microporous filter membrane or micropore filter element aperture the best are 0.22 μm.
The present invention damages stomach lining rat model protective effect experimental result for foundation with okra fermented juice to absolute ethyl alcohol.After this experiment shows that okra fermented juice dilutes 30 times, 20ml/kg okra fermented juice dosage group has the effect of protection gastric mucosa, compares have significant difference with damage model group.
The present invention has good effect relative to prior art:
The present invention is okra active principle is degraded into the small-molecule substance that can be able to be absorbed by stomach and intestine by spontaneous fermentation with okra fermentation mucus juice; especially the material such as viscous polysaccharide of gained of fermenting has significantly protection stomach lining effect; compare with common extract with okra itself; the molecular weight of material of fermentation gained is less; the active ingredient obtained is more, more easily absorbs and applies.The effect of better protection stomach lining is had relative to Abelmoschus Esculentus Linn extract.
The okra fermented juice fluid composition color and luster produced by carrying out spontaneous fermentation under certain condition is faint yellow to yellow; have the soft material of refrigerant tart flavour homogeneous, without the organoleptic feature of bitter taste; unique flavor; maintain natural nutrient component and the active material of okra, especially there is the health-care efficacy of protection stomach lining.
The present invention proposes the quality standard of concrete suitability for industrialized production and production technology and product according to different auxiliary material adding proportion and kind; Again, the present invention is as health products, and its product form can be oral liquid, fruit drink or other fluid products, lozenge, cavity disintegrated tablet or other tablet.Therefore, it is domestic okra deep development, provides processing and utilization okra technological approaches, expands application, improve the economic worth of okra.
Detailed description of the invention
Below by instantiation, realization means of the present invention is described, but is not limited only to this.
(1) product of the present invention and preparation method
Embodiment 1
Be cut into fragment after being cleaned by the okra of maturation, add honey and put into airtight container and carry out fermentation 4 months at 23 DEG C-28 DEG C, middlely to be bled off by the gas of generation, soluble solid content reaches 9.0%, and pH value reaches 3.5; Get okra fermented juice 85 DEG C sterilization 20 seconds.Solution temperature is cooled to less than 26 DEG C to filter through row, and filtered fluid to ferment Normal juice as okra.
Preparation okra oral liquid 100 milliliters: get okra Normal juice 70 milliliters, wherein soluble solid content is 5%, pH value is 4.0, by glycine 1.0 grams, peppermint oil 0.1 milliliter (peppermint oil proportion is 1g/ml), Sodium Benzoate 0.05 gram, with after appropriate water-soluble solution mixing, adds in the Normal juice after okra dilution, with water constant volume to amount of preparation, record into oral liquid.
Embodiment 2
Be cut into fragment after being cleaned by the okra of maturation, add honey and put into airtight container and carry out fermentation 2 months at 23 DEG C-28 DEG C, middlely to be bled off by the gas of generation, soluble solid content reaches 7.0%, and pH value reaches 4.0; Get okra fermented juice 85 DEG C sterilization 15 seconds.Solution temperature is cooled to less than 26 DEG C to filter, and filtered fluid to ferment Normal juice as okra.
Preparation okra oral liquid 100 milliliters: get the rear Normal juice 20 milliliters of okra dilution, wherein soluble solid content is 9.0%, pH value is 3.0, by glycine or alanine 1.0 grams, peppermint oil 0.5 milliliter (peppermint oil proportion is 1g/ml), Sodium Benzoate 0.05 gram is with after appropriate water-soluble solution mixing, add in the Normal juice after okra dilution, filter with the 15 μm of nylon membranes in aperture or carry out ultrafiltration get filtrate with retaining aperture 100,000 hollow cellulose film, with water constant volume to amount of preparation, again the filtrate of preparation is carried out filtration sterilization with the miillpore filter of 0.45 μm or filter core, record into oral liquid.
Embodiment 3
Be cut into fragment after being cleaned by the okra of maturation, add honey and put into airtight container and carry out fermentation 3 months at 23 DEG C-28 DEG C, middlely to be bled off by the gas of generation, soluble solid content reaches 7.0%, and pH value reaches 3.5; Get okra fermented juice 70 DEG C sterilization 20 seconds.Solution temperature is cooled to less than 26 DEG C to filter, and filtered fluid to ferment Normal juice as okra.
Preparation okra oral liquid 100 milliliters: get the rear Normal juice 20 milliliters of okra dilution, wherein soluble solid content is 9.0%, pH value is 3.0, by glycine or alanine 0.5 gram, peppermint oil 0.5 milliliter (peppermint oil proportion is 1g/ml), Sodium Benzoate 0.05 gram is with after appropriate water-soluble solution mixing, add in the Normal juice after okra dilution, filter with the 60 μm of nylon membranes in aperture or carry out ultrafiltration get filtrate with retaining aperture 400,000 hollow cellulose film, with water constant volume to amount of preparation, record into oral liquid.
Embodiment 4
Be cut into fragment after being cleaned by the okra of maturation, add honey and put into airtight container and carry out fermentation 3 months at 23 DEG C-28 DEG C, middlely to be bled off by the gas of generation, soluble solid content reaches 8.0%, and pH value reaches 3.5; Get okra fermented juice 70 DEG C sterilization 30 seconds.Solution temperature is cooled to less than 26 DEG C to filter, and filtered fluid to ferment Normal juice as okra.
Preparation okra oral liquid 100 milliliters: get the rear Normal juice 20 milliliters of okra dilution, wherein soluble solid content is 9.0%, pH value is 3.0, by glycine or alanine 1.5 grams, peppermint oil 0.5 milliliter (peppermint oil proportion is 1g/ml), Sodium Benzoate 0.05 gram is with after appropriate water-soluble solution mixing, add in the Normal juice after okra dilution, filter with the 15 μm of nylon membranes in aperture or carry out ultrafiltration get filtrate with retaining aperture 100,000 hollow cellulose film, with water constant volume to amount of preparation, again the filtrate of preparation is carried out filtration sterilization with the miillpore filter of 0.22 μm or filter core, record into oral liquid.
Embodiment 5
Be cut into fragment after being cleaned by the okra of maturation, add honey and put into airtight container and carry out fermentation 4 months at 23 DEG C-28 DEG C, middlely to be bled off by the gas of generation, soluble solid content reaches 9.0%, and pH value reaches 3.5; Get okra fermented juice 85 DEG C sterilization 30 seconds.Solution temperature is cooled to less than 26 DEG C to filter, and filtered fluid to ferment Normal juice as okra.
Preparation okra oral liquid 100 milliliters: get the rear Normal juice 90 milliliters of okra dilution, wherein soluble solid content is 9.0%, pH value is 3.0, by glycine or alanine 1.5 grams, Sodium Benzoate 0.1 gram is with after appropriate water-soluble solution mixing, add in the Normal juice after okra dilution, filter with the 15 μm of nylon membranes in aperture or carry out ultrafiltration get filtrate with retaining aperture 200,000 hollow cellulose film, with water constant volume to amount of preparation, again the filtrate of preparation is carried out filtration sterilization with the miillpore filter of 0.22 μm or filter core, record into oral liquid.
(2) okra fermented juice is to gastric mucosa injury protection effect caused by absolute ethyl alcohol
Embodiment 6
50 rats are divided into water control group, shitosan control group and basic, normal, high (10ml/kg, 20ml/kg, 40ml/kg) 3 tested material groups at random by body weight.Animal gavage tested material 15 days, fasting 48 hours before dissecting, experiment end gavage tested material on the same day only respectively organizes gavage absolute ethyl alcohol 1ml/ again after 1 hour, animal is put to death after 1 hour, get stomach, fix 20 minutes by 2% formalin, cut off along greater curvature, clean content, measurement stomach lining is hemorrhage, ulcer area.(as table 1)
Table 1 absolute ethyl alcohol causes gastric mucosa injury protection effect experiment
Experimental result shows: model control group, positive controls, okra fermented juice three dosage groups can damage stomach lining through absolute ethyl alcohol gavage; okra three dosage gastric infusions are after 15 days; middle high dose has the effect of significantly protection stomach lining; clear superiority is possessed as functional health care product and food; and from natural materials, toxic and side effect aspect has a clear superiority in.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from Spirit Essence of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.

Claims (10)

1., based on a fluid composition for okra fermented juice protection stomach lining, it is characterized in that, the component of described fluid composition and proportioning are:
Okra fermented juice (percent by volume) 20%-99.94%;
Flavouring (percent weight in volume) 0.05%-1.5%;
Anticorrisive agent (percent weight in volume) 0.01%-0.1%;
Surplus is water.
2. fluid composition according to claim 1, is characterized in that, described flavouring is selected from one in glycine, alanine, peppermint oil, orange-seed oil or its mixture.
3. the fluid composition according to claims 1, is characterized in that, described anticorrisive agent is selected from one in benzoic acid, potassium sorbate, ethyl-para-hydroxybenzoate or its mixture.
4. the fluid composition according to the arbitrary claim of claims 1 to 3, is characterized in that the pH value of described fluid composition is 3.0 – 5.5, soluble solid content is 2.5%-12.0%.
5., according to the fluid composition that claims 4 are stated, it is characterized in that described composition pH value is 3.0 – 4.5, soluble solids content is 5.0% – 9.0%.
6. a kind of fluid composition based on okra fermented juice protection stomach lining of the arbitrary claim of claim 1 – 5 is in the application preparing health products, food or the medicine of protecting stomach lining.
7. prepare a method for the fluid composition of okra fermented juice described in the arbitrary claim of claim 1 – 6, comprise step:
(1) okra of maturation is placed in 23-28 DEG C of closed container to ferment 1 – 4 months, gets okra fermentation mucus juice, bus sterilization, filter to get filtrate;
(2) with adding in filtrate after water-soluble solution flavouring and anticorrisive agent;
(3) amount of preparation is settled to water.
8. prepare fluid composition method according to claim 7, it is characterized in that being the nylon membrane class filter media of 10-100 μm by step (1) fermentation mucus juice filtering technique, or retain aperture 4 – 400,000 molecular weight polymeric hollow cellulose membrane with film and retain.
9. prepare fluid composition method according to claim 7, it is characterized in that the material that retains after step (3) being prepared passes through pasteurization.
10. okra fermentation mucus juice is preparing the application of the health products of protection stomach lining, food or medicine.
CN201510936882.7A 2015-12-15 2015-12-15 Liquid composition capable of protecting gastric mucosae on basis of fermented juice of hibisus essulentus L. and preparation method Pending CN105495236A (en)

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Publication number Priority date Publication date Assignee Title
CN107496473A (en) * 2017-08-11 2017-12-22 广东维尼健康科技有限公司 Application of the okra water extract in digestive tract function is protected
CN112493458A (en) * 2020-11-30 2021-03-16 湖南华诚生物资源股份有限公司 Compound sweetener for improving mouthfeel of rubusoside and preparation method thereof

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CN104223271A (en) * 2014-10-13 2014-12-24 江苏省农业科学院 Okra lactobacillus fermented beverage
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CN101791139A (en) * 2010-02-01 2010-08-04 阚欢 Blood sugar level or blood pressure regulating liquid composite based on Noni fermented juice and preparation method thereof
CN104223271A (en) * 2014-10-13 2014-12-24 江苏省农业科学院 Okra lactobacillus fermented beverage
CN104305429A (en) * 2014-11-18 2015-01-28 黄秋函 Fermentation type okra tea drink

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496473A (en) * 2017-08-11 2017-12-22 广东维尼健康科技有限公司 Application of the okra water extract in digestive tract function is protected
CN112493458A (en) * 2020-11-30 2021-03-16 湖南华诚生物资源股份有限公司 Compound sweetener for improving mouthfeel of rubusoside and preparation method thereof

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