CN105494418B

CN105494418B - Barrier agent for inhibiting harmful microorganism infection in air fine particles

Info

Publication number: CN105494418B
Application number: CN201410504767.8A
Authority: CN
Inventors: 叶茂强
Original assignee: Shanghai Xuanren Information Technology Co ltd
Current assignee: Shanghai Xuanren Information Technology Co ltd
Priority date: 2014-09-26
Filing date: 2014-09-26
Publication date: 2020-08-07
Anticipated expiration: 2034-09-26
Also published as: CN105494418A

Abstract

The invention provides a blocking agent for inhibiting harmful microorganism infection in air fine particles, which comprises the following components: deoxyribonucleic acid, humectant and antimicrobial agent.

Description

Barrier agent for inhibiting harmful microorganism infection in air fine particles

Technical Field

The invention relates to a blocking agent which takes natural animal and plant components as main bodies and can quickly block and inhibit harmful microorganisms in fine air particles from invading human bodies to contact with mucous membranes and induce the infection of microorganisms such as bacteria or viruses.

Background

Fine particles suspended in the air contain a large number of harmful microorganisms such as viruses and harmful bacteria. These harmful microorganisms can be carried in air by air flow or other particulate matter, enter the human body through human respiratory or skin mucosa, and cause bacterial and viral infections and diseases of the respiratory tract or immune system. With the increase and long-term growth of air pollution in living environments, the spread of these harmful microorganisms and the threat of invasion to the human body are becoming more and more normal and malignant. When the climate temperature is proper, explosive spread is more likely to occur, which causes great harm to the health and the society of people.

For a long time, people use antibiotics and antibacterial and antiviral drugs to prevent or inhibit the infection of harmful microorganisms, and how to avoid the drug resistance of the antibacterial and antiviral drugs is a big problem in the field of inhibiting the infection of the harmful microorganisms. With the continuous and large investment and use of more powerful broad-spectrum antibacterial and antiviral drugs, the drug resistance problem of harmful microorganisms is getting worse. Even the vast majority of new influenza viruses are born from resistant varieties. Experts have given warnings that humans may face the crisis of survival in the drug-free antibacterial and antiviral era before antibacterial and antiviral drugs appear. Moreover, relying solely on antimicrobial agents is little effective in effectively blocking and inhibiting harmful microorganisms from turning their way to cause infection or other pathological reactions before they begin to infect.

How to use the non-medicament separation mode, before the harmful microorganisms in the air particulate matter invade the human body to cause virus or bacterial infection, the harmful microorganisms are effectively separated and shielded, the activity and the spread infection of the harmful microorganisms can be inhibited, the self regulation of the human body and the enhancement of the immunity resistance capability are helped to improve the inherent defense capability against the invasion of the harmful microorganisms, but not the situation that a large amount of medicaments are thrown to kill after the harmful microorganisms invade the human body to cause serious drug resistance, and simultaneously, a large amount of valuable useful bacteria and microorganisms in the human body are all included, which is a key topic related to how to establish a new prevention and treatment system.

In the non-drug barrier method, masks have been widely used so far as the simplest self-defense means for filtering and preventing harmful microorganisms in air particles from invading human body. However, although the mask can block the diffusion of larger particles and saliva spitting stars, the mask cannot practically shield the invasion of harmful microorganism fine particles with tiny diameters, and has the defects of being not tightly attached to the face, inconvenient to wear, damaging beauty, increasing the breathing burden, being incapable of being used for a long time and the like.

In recent years, attempts have been made to achieve the function of blocking harmful microorganisms such as viruses by using a high molecular polymer such as polysaccharide pectin or chicle. However, the method consisting of a simple adhesive component is difficult to realize the barrier effect quickly and effectively, and the method is a fatal difficulty that the method is difficult to be widely applied because the total barrier to harmful microorganism particles cannot be ensured, and the emergency inhibition measure when the harmful microorganisms once adsorb to the mucosa and begin to cause pathological reaction to cause infection is lacked.

Another technical proposal proposes a method of inhibiting harmful microorganisms by combining a saccharide gum with an antimicrobial agent, and is expected to improve the inhibitory effect against the initial infection of the mucous membranes once they are adsorbed to the mucous membranes. Only because only the viscous component of the single sugar gum is used for blocking and shielding the invasion of harmful microorganism particles, the function is greatly limited, the blocking effect is not obvious, and the foreign body feeling of skin or mucosa is easy to feel uncomfortable after the use, so that the better mucosa affinity experience is difficult to achieve. Moreover, the antimicrobial agents to be combined are limited to only some chemically synthesized pharmaceutical ingredients that have been shown to be at a greater risk of drug resistance, while antimicrobial ingredients from natural plant extracts that have been shown to be effective with fewer or no side effects are completely ignored.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides a blocking agent which acts on a human body through non-medicines, prevents harmful microorganisms from entering the human body to cause infection, and inhibits the harmful microorganism infection in fine air particles.

In order to achieve the above object, the present invention provides a barrier agent for inhibiting infection of harmful microorganisms in fine particulate air, comprising: deoxyribonucleic acid, humectant and antimicrobial agent.

Further, the deoxyribonucleic acid is sodium deoxyribonucleic acid.

Further, the deoxyribonucleic acid, the humectant and the antimicrobial agent satisfy the following weight ratio: deoxyribonucleic acid is more than or equal to 0.2 percent and less than or equal to 3.5 percent; the humectant is more than or equal to 2.0 percent and less than or equal to 20 percent; 0.01 percent to 2 percent of antimicrobial agent.

Further, the blocking agent also comprises pectin, and the pectin meets the following weight ratio: pectin is more than or equal to 0.05 percent and less than or equal to 3.5 percent.

Furthermore, the blocking agent also comprises water-soluble chitosan, and the water-soluble chitosan meets the following weight ratio: the water-soluble chitosan is more than or equal to 0.1 percent and less than or equal to 8 percent.

Further, the blocking agent also comprises ethanol, and the ethanol satisfies the following weight ratio: ethanol is more than or equal to 2.0 percent and less than or equal to 25 percent.

Further, the blocking agent also comprises butanediol, and the butanediol meets the following weight ratio: butanediol is more than or equal to 1.2 percent and less than or equal to 20 percent.

Further, the antimicrobial agent is an antimicrobial agent extracted from a natural plant.

Further, the pH of the blocking agent is 5.5 to 7.

Still further, the barrier agent is characterized by being applied to the skin or mucosal surface.

Further, the blocking agent is characterized in that the blocking agent is sprayed on the inner wall of the oral cavity or the nostril, or is attached to a mask, a nasal plug and an air filter screen in a spraying or immersion way, or is directly sprayed in the air or the surface of an object which is possibly polluted by harmful microorganisms.

Compared with the prior art, the blocking agent provided by the invention mainly shields asphyxia and assists antibiotic killing; the medicament is characterized by supplementing the medicament, can quickly and effectively block the invasion of harmful microorganisms in air fine particles through a unique combined formula and action mode, and inhibit and relieve allergy, infection and other pathological reactions caused by the invasion of harmful microorganism fine particles, which are difficult to solve by other similar products and even medicaments.

The effect of the barrier agent provided by the invention comprises the following steps: quick-acting and powerful shielding and blocking when harmful microorganisms in the air fine particles invade, and timely resisting and killing once the harmful microorganisms invade. Firstly, an intangible barrier layer is formed on the surface of human mucosa through the interaction of deoxyribonucleic acid and a humectant, so that harmful microorganism particles in fine air particles are rapidly and effectively blocked, adsorbed and condensed, and are coagulated and inactivated, and cannot contact with the mucosa to cause various pathological reactions such as allergic infection and the like; and then the combined action of the antimicrobial components can kill harmful microorganisms which are invaded and contacted with the mucosa once the leakage net is invaded in time or obstruct and interfere the reproduction and the diffusion of the microorganisms, thereby effectively inhibiting the infection and the infection caused by the harmful microorganisms.

The barrier agent provided by the invention can quickly and effectively adsorb, capture and agglomerate fine particles by utilizing the special macromolecular double-helix structure and viscosity characteristic of deoxyribonucleic acid; meanwhile, through the combination of the humectant components, the structural characteristics of deoxyribonucleic acid are better stabilized, the state and the action environment of the deoxyribonucleic acid serving as the barrier component are maintained for a longer time, the barrier effects such as adhesion and agglomeration can be better adjusted and enhanced, and the optimal mucosa affinity state is maintained; or water-soluble chitosan or pectin is added to enhance the adsorption, capture and coagulation effects and the effect persistence; meanwhile, a trace of antimicrobial agent is added to enhance the functions of preventing and interfering the reproduction and diffusion of harmful microorganisms invading mucosa, resisting bacteria and viruses and the like to inhibit the infection of the harmful microorganisms in the subsequent blocking process.

Compared with the similar or similar products, the barrier agent provided by the invention has the characteristics of more unique and optimized action mode and quicker and more obvious barrier effect. Compared with the method of singly using deoxyribonucleic acid or sugar gum glycerin viscous components, the method has the advantages of quicker and more effective blocking effect, more stability and durability and more obvious effect of inhibiting infection diffusion. Compared with the method of killing by using the single antibacterial and antiviral medicament, the method can greatly reduce the harm and risk of medicament resistance, improve the action environment of the antimicrobial agent on the mucosa, and has the effects of blocking and shielding the invasion of harmful microorganisms and inhibiting the occurrence of infection diffusion more directly, simply and easily. Moreover, in the component combination ratio of the invention, the structural characteristics of adsorbing, capturing and condensing harmful microorganism fine particles of deoxyribonucleic acid can be exerted more fully and effectively, and the affinity of the mucosa is better and more durable; and by adding the optimized combination of trace antimicrobial agent and humectant or pectin and other viscous barrier components, compared with the method of combining the sugar gum and the antimicrobial agent, the effects of blocking the invasion of harmful microorganisms and inhibiting infection are quicker, more obvious and more effective, no foreign body sensation is uncomfortable, and the mucosa affinity is better and more durable.

The pH value of the barrier agent provided by the invention is adjusted to be between 5.5 and 7 so as to enhance the affinity of the mucosa skin and resist the invasion of harmful microorganisms in external fine particles.

The components of the barrier agent provided by the invention are all natural animal and plant extracts, are generally recognized as non-toxic materials without side effects, have stable performance and good mucosa affinity experience, and can be suitable for different people such as men, women, old, young, pregnant, infant patients and the like to use for a long time in different seasons and different occasions.

The blocking agent provided by the invention is used as a special colorless, odorless and intangible liquid blocking film cover directly acting on skin mucosa, and can replace the function of most masks. Can solve the defects of difficult face fitting, inconvenient wearing, damage to beauty, increased breathing burden, incapability of long-time use and the like caused by common wearing of the mask.

The blocking agent provided by the invention is in a colorless, odorless and invisible liquid form, and can be conveniently overlapped or combined with any intermediaries such as a mask, a nasal obstruction and a filter net cover, so as to meet different use requirements and strengthen the blocking effect of the blocking agent.

The barrier agent provided by the invention is directly sprayed on human skin and inner cavity mucosa in a spraying mode. The barrier effect can last for 2-6 hours at the sprayed part of the skin or mucosa in the state of not being cleaned.

Drawings

The advantages and spirit of the present invention can be further understood by the following detailed description of the invention and the accompanying drawings.

FIG. 1 is a different state view of particulate matter under a microscope;

FIG. 2 is a technical schematic of a blocking agent according to the present invention;

FIG. 3 is a graph showing the experimental effect of the blocking agent according to the present invention.

Detailed Description

Specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

As a result of the known invention and method of how to block the invasion of infections by harmful microorganisms, there are different drawbacks: such as a single polysaccharide viscous component, the mucosa affinity is poor, and the barrier effect is difficult to realize quickly and effectively; and can not ensure the total number of harmful microorganism particles to be blocked, and lacks emergency measures for solving the problem that once the harmful microorganisms are adsorbed on the mucosa and begin to cause pathological reaction to cause infection; the single antimicrobial component brings serious drug resistance risk while killing harmful microorganisms, and cannot effectively block and shield the harmful microorganisms at the beginning of invasion; however, although the effect of inhibiting infection is enhanced by the addition of the antimicrobial agent, the risk of drug resistance cannot be effectively avoided, and the barrier effect of a single sugar gum viscous component is not significant, but rather, the components combined by the sugar gum and the antimicrobial agent have the limitation of poor mucosal affinity and discomfort.

The purpose of the present invention is to provide a barrier agent which is mainly composed of a non-pharmaceutical composition, effectively blocks the invasion interference of harmful microbial particles, inhibits the harmful microbial particles from contacting mucosa and inducing pathological reactions such as bacterial or viral infections, and can quickly kill or inhibit the harmful microbial particles once they invade the barrier agent. The barrier agent forms an invisible barrier layer on the surface of the mucous membrane by the interaction between deoxyribonucleic acid extracted from natural food and a humectant. When harmful microorganism particles in the air invade, the harmful microorganism particles can be quickly and effectively blocked, adsorbed and agglomerated outside the surface layer of the mucosa, so that the harmful microorganism particles are coagulated and inactivated and cannot directly contact the mucosa to cause various pathological reactions such as allergic infection and the like, and the effect of inhibiting the harmful microorganism is achieved. Meanwhile, the action environment of the antimicrobial agent on the mucosa can be adjusted, and the action effect of the antimicrobial agent is enhanced. By the antimicrobial component in the barrier agent, harmful microorganisms which once invade and contact with mucosa can be killed rapidly or the propagation and diffusion of the harmful microorganisms can be prevented rapidly, so that infection and other pathological reactions caused by the harmful microorganisms can be effectively inhibited.

The barrier agent provided by the invention has good mucosa affinity experience, is safe and free of side effect, and can be used by different people for a long time in different occasions.

FIG. 1 is a schematic diagram showing the principle of adsorption of DNA macromolecules. The left picture in fig. 1 is the fine particles containing harmful microorganisms in a suspended state, which are mutually repelled and irregularly distributed; the middle figure shows that after the pectin component is sprayed, the particles can be promoted to adhere and connect to form chains and rows; the right picture shows that after the spraying of sodium deoxyribonucleate, the particles can be promoted to agglutinate and polymerize, agglomerate, harden and inactivate, and the surface activity and the contact with mucosa of the suspended particles can be effectively blocked and inhibited. As can be seen from FIG. 1, both pectin and sodium deoxyribonucleotide have the effect of adsorbing and aggregating fine particles, and the effect of adsorbing, aggregating and polymerizing deoxyribonucleic acid is more significant.

Fig. 2 shows the functional relationship of each component. The fine particles in the air are usually positively charged, and are adsorbed, condensed and coated by macromolecular deoxyribonucleic acid with negative charges and double helix structure and adhesion property to form blocks; the humectant with certain adsorption and agglomeration capacity can greatly improve and stably maintain the adsorption and agglomeration and other barrier capacities of fine particles containing harmful microorganisms through the interaction with deoxyribonucleic acid; the antimicrobial agent cooperates with the barrier process and further kills or inhibits the propagation of harmful microorganisms in the fine particulate matter and causes infection.

Fig. 3 is a test example showing the effect of spraying the blocking agent on the fine particles containing harmful microorganisms in the embodiment using the mask as the intermediary carrier. The upper segment is the test end, uses ordinary dust mask, adds water spray or this agent respectively, detects the separation effect of particulate matter under each condition. A1 is the barrier of the mask of control 1; b1 is the blocking amount of mask control 2 added with distilled water; c1 is the blocking amount of the mask added with the blocking agent. The lower section is a test end, and a professional medical dust removal and sterilization mask with the particulate blocking rate of nearly 100% is used for detecting the residual quantity (concentration scale) of particles blocked by the dust mask under each control condition. A2 is the residual quantity of the mask of control 1 after obstruction; b2 is the residual quantity of the mask of control 2 after the water is blocked by the added spray distillation; c2 is the residual quantity of the blocking agent sprayed on the mask after blocking. The method is that the amount of the particles absorbed and blocked on the surface of the mask is measured after the same tool, mode, attraction force and attraction time (30 seconds) are used for carrying out attraction in two sections from a control box body filled with the same amount of dry suspended particles. The first section filters and blocks through the different tested body cover surfaces of ABC, and after the blocking amount is measured, the second section intercepts the residual particle amount by using a special filter cover and compares the residual particle amount. According to the result of concentration scale, the blocking amount of the mask sprayed with the blocking agent on the particles is about more than 1 time of that of a common mask or the mask sprayed with distilled water, and the amount of the particles remained after the blocking of the mask sprayed with the blocking agent is less than half of that of the common mask.

Table 1 shows that in an embodiment of an oral spray containing sodium deoxyribonucleate, a humectant, an antimicrobial agent, or a mixture of sodium deoxyribonucleate, humectant, antimicrobial agent and pectin, when the oral spray is sprayed in an environment containing a large amount of harmful microorganism airborne particulates, the effects of the oral spray include inhalation blocking effect, activity inhibition and killing effect, infection inhibition effect, pharyngeal discomfort improvement, mucosal affinity (no foreign body discomfort), effect persistence, drug resistance and other side effects, and the effects of the oral spray are greatly improved compared with the effects of only using a single sodium deoxyribonucleate component or a single pectin component or a single antimicrobial component in the same ratio. Especially, the performance and the effect are improved more obviously in the aspects of extremely important effect persistence, mucosa affinity (no foreign body feeling and discomfort) and side effect when the product is used as a common harmful microorganism resistant barrier product.

TABLE 1

The deoxyribonucleic acid is extracted from fish, and especially sodium deoxyribonucleic acid (DNA-Na) is used as an optimal technical effect.

The humectant provided by the invention is a single humectant component or a humectant component formed by combining a plurality of humectant components. Including but not limited to one or more of the following humectant components: polyhydric alcohol humectants such as glycerol, polyethylene glycol, propylene glycol, hexylene glycol, polypropylene glycol, xylitol, sorbitol, and mixtures thereof; biochemical humectant components such as collagen, mucopolysaccharide, hyaluronic acid, glycoprotein and chondroitin sulfate; an amino acid humectant component; provitamin B5, ceramide and other natural moisturizing factor components.

The antimicrobial agent comprises a medicinal antimicrobial agent component and a non-medicinal antimicrobial agent component, wherein the non-medicinal antimicrobial agent component is used as a main action component, the non-medicinal antimicrobial agent component comprises one or more natural plant extract components which are combined, and the antimicrobial agent component comprises but not limited to purslane, pomegranate peel, houttuynia cordata, dyers woad leaf, climbing groundsel, coptis chinensis, scutellaria baicalensis, fibraurea stem, trollflower, picria felterrata, isatis root, radix rehmanniae, radix curcumae, rhizoma anemarrhenae, centella asiatica, pogostemon cablin, rhizoma acori graminei, liquorice, fennel, hawthorn, Chinese juniper leaf, barberry and the like.

The Pectin (Pectin) mentioned in the invention is extracted from the refined components of the fruit.

The Ethanol (Ethanol) is extracted from sugar-containing or starchy plant.

The butanediol (Butylene Glycol) mentioned in the invention is a high-efficiency performance stabilizer and bacteriostatic agent component besides the moisturizing effect.

The barrier agent provided by the invention can be prepared by the following method: adding sodium deoxyribonucleate into part of refined water to dissolve to obtain a solution A, uniformly mixing all the components of the humectant, heating to obtain a solution B, uniformly mixing the solution A and the solution B, adding the rest refined water, adjusting the pH value to 5.5-7, sterilizing and packaging to obtain the finished product. When the antimicrobial agent is added, the antimicrobial agent can be dissolved in partial refined water to obtain a solution C, then the solution A, the solution B and the solution C are uniformly stirred, the rest refined water is added, the pH value is adjusted to 5.5-7, and the antimicrobial agent is sterilized and packaged. When other components are added, pectin can be added into part of refined water and heated to obtain solution D, then the solution A, the solution B, the solution C and the solution D or the solution A, the solution B and the solution D are uniformly stirred, the rest refined water is added, the pH value is adjusted to 5.5-7, and the pectin is sterilized and packaged. Or adding part of the refined water into butanediol to dissolve to obtain a solution E, uniformly stirring the solution A, the solution B, the solution D and the solution E or the solution A, the solution B, the solution C, the solution D and the solution E, adding the rest refined water, adjusting the pH value to 5.5-7, sterilizing and packaging. Or uniformly stirring the solution A, the solution B, the solution D and the solution E or the solution A, the solution B, the solution C, the solution D and the solution E, adding ethanol, adding the rest refined water, adjusting the pH value to 5.5-7, sterilizing and packaging.

The final component ratio satisfies the following weight ratio:

deoxyribonucleic acid is more than or equal to 0.2 percent and less than or equal to 3.5 percent, humectant is more than or equal to 2.0 percent and less than or equal to 20 percent, antimicrobial agent is more than or equal to 0.00 percent and less than or equal to 2 percent, pectin is more than or equal to 0.2 percent and less than or equal to 3.5 percent, butanediol is more than or equal to 4 percent and less than or equal to 10 percent, and ethanol is more than or equal to 2.0 percent.

First embodiment

In a first embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting and eliminating infection caused by harmful microorganism invasion in fine particulate air in the form of a portable facial, oral, ear-nose-eye spray. In the method, the deoxyribonucleic acid component is sodium deoxyribonucleic acid, and a humectant and refined water are added.

In the embodiment, the content of the sodium deoxyribonucleate is more than 0.08% and less than 1.6%, the content of the humectant is more than 6.0% and less than 20%, and the balance is refined water, and the pH value is adjusted to 5.5-7.

In the embodiment, the sodium deoxyribonucleic acid is extracted from fish, has a molecular weight of more than 30kDa, has negative charges, and has strong activity and effect of adsorbing condensed molecules. In the blocking agent, sodium deoxyribonucleate is used as a main active ingredient for realizing the absorption, agglomeration and inhibition of harmful microorganisms and activity thereof in fine particles; adding humectant to stabilize and adjust the structural characteristics, action state and environment of each component, prolong the barrier action time, maintain the optimum mucosa affinity state, and enhance the effect and effect of blocking harmful microorganisms in fine particulate matters such as adhesion and coagulation; adding refined water to dilute each active ingredient to the optimal active concentration.

In the embodiment, the spraying mode is adopted to directly spray the mixture on human skin and inner cavity mucosa. The spraying amount is adjusted according to the spraying position and the environmental climate, and is generally more than 0.01ml and less than 0.5 ml. The barrier effect can last for 2-6 hours at the sprayed part of the skin or mucosa in the state of not being cleaned.

Under the action of the embodiment, the harmful microorganism invasion in the air fine particulate matters can be blocked quickly and effectively, the activity of the harmful microorganisms is inhibited and even killed, and the allergy, infection and other pathological reactions caused by the harmful microorganism inhalation invasion in the air fine particulate matters, which are difficult to solve by a plurality of other similar products and even medicaments, are inhibited and relieved. Forming a colorless, odorless and invisible liquid barrier film cover. Is safe and has no side effect. Can replace most masks. The mask used as the medium and the test result show that when the blocking agent is sprayed, the blocking amount of the particles is about more than 1 time of that of a common mask or a mask added with distilled water, and the amount of the residual particles after one-time blocking is less than half of that of the common mask.

Second embodiment

In a second embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting and eliminating infection caused by harmful microorganism in fine particulate matter in the air in the form of a portable facial, oral, ear-nose-eye spray. In the method, deoxyribonucleic acid is taken as a component, sodium deoxyribonucleic acid is added with water-soluble chitosan or pectin or a mixture of chitosan and pectin, and a humectant and refined water are added.

In the embodiment, the content of the sodium deoxyribonucleate is more than 0.08% and less than 1.0%, the content of the water-soluble chitosan is more than 0.1% and less than 6%, or the content of the pectin is more than 0.05% and less than 2.5%, or the content of the mixture of the chitosan and the pectin is more than 0.1% and less than 7%, the content of the humectant is more than 2.0% and less than 18%, and the balance is prepared with purified water, and the pH value is adjusted to be 5.5-7.

In the embodiment, the sodium deoxyribonucleic acid is extracted from fish, has a molecular weight of more than 30kDa, has negative charges, and has strong activity and effect of adsorbing condensed molecules. The pectin is extracted from natural fruit and has molecular weight of above 30 kDa. The chitosan is water soluble chitosan component. Sodium deoxyribonucleate is used as a main active ingredient for realizing the absorption, agglomeration and inhibition of harmful microorganisms and the activity thereof in the fine particulate matters; adding pectin or water-soluble chitosan or the mixed components of pectin and water-soluble chitosan to enhance and stabilize the performance of adhering harmful microorganisms in the fine particles; adding humectant to stabilize and adjust the structural characteristics, action state and environment of each component, prolong the barrier action time, maintain the optimum mucosa affinity state, and enhance the effect and effect of blocking harmful microorganisms in fine particulate matters such as adhesion and coagulation; adding refined water to dilute each active ingredient to the optimal active concentration.

Under the action of the embodiment, the invasion of harmful microorganisms in fine particles in the air can be blocked quickly and effectively, and the allergy, infection and other pathological reactions caused by the invasion of the harmful microorganisms in the fine particles in the air, which are difficult to solve by a plurality of other similar products and even medicaments, can be inhibited and relieved. Forming a colorless, odorless and invisible liquid barrier film cover. Is safe and has no side effect. Can replace most masks. The mask used as the medium and the test result show that when the blocking agent is sprayed, the blocking amount of the particles is about more than 1 time of that of a common mask or a mask added with distilled water, and the amount of the residual particles after one-time blocking is less than half of that of the common mask.

Third embodiment

In a third embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting and eliminating infection caused by harmful microorganism invasion in fine particulate air in the form of a portable facial, oral, ear-nose-eye spray. In the method, the deoxyribonucleic acid component is sodium deoxyribonucleic acid, and the sodium deoxyribonucleic acid component is added with a humectant, an antimicrobial agent and refined water.

In the embodiment, the content of the sodium deoxyribonucleate is more than 0.18% and less than 3.5%, the content of the humectant is more than 6.0% and less than 20%, the content of the antimicrobial agent is more than 0.01% and less than 1.0%, and the balance is refined water, and the pH value is adjusted to be 5.5-7.

In the embodiment, the sodium deoxyribonucleic acid is extracted from fish, has a molecular weight of more than 30kDa, has negative charges, and has strong activity and effect of adsorbing condensed molecules. Sodium deoxyribonucleate is used as a main active ingredient for realizing the absorption, agglomeration and inhibition of harmful microorganisms and the activity thereof in the fine particulate matters; the added antimicrobial agent component is extracted from natural animals and plants, and can kill harmful microorganisms once invading and contacting mucosa or quickly obstruct and interfere the propagation and the spread of the harmful microorganisms, thereby effectively inhibiting the infection and the infection of the harmful microorganisms; adding humectant to stabilize and adjust the structural characteristics, action state and environment of each component, prolong the barrier action time, maintain the optimum mucosa affinity state, and enhance the effect and effect of blocking harmful microorganisms in fine particulate matters such as adhesion and coagulation; adding refined water to dilute each active ingredient to the optimal active concentration.

Under the action of the embodiment, the invasion of harmful microorganisms in the air fine particles can be blocked quickly and effectively, and the allergy, infection and other pathological reactions caused by the invasion of the harmful microorganisms in the air fine particles, which are difficult to solve by a plurality of other similar products and even medicaments, can be inhibited and relieved. Forming a colorless, odorless and invisible liquid barrier film cover. Is safe and has no side effect. Can replace most masks. The mask used as the medium and the test result show that when the blocking agent is sprayed, the blocking amount of the particles is about more than 1 time of that of a common mask or a mask added with distilled water, and the amount of the residual particles after one-time blocking is less than half of that of the common mask.

Fourth embodiment

In a fourth embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting, and eliminating infection from fine airborne particles by harmful microorganisms in the form of a portable facial, oral, otonasal, and ophthalmic spray. In the method, deoxyribonucleic acid (DNA) is selected from sodium DNA, a humectant, an antimicrobial agent, water-soluble chitosan or pectin or a mixture of chitosan and pectin and refined water are added.

In the embodiment, the content of the sodium deoxyribonucleate is more than 0.18% and less than 3.5%, the content of the humectant is more than 6.0% and less than 20%, the content of the antimicrobial agent is more than 0.01% and less than 2.0%, or the content of the water-soluble chitosan is more than 0.1% and less than 5%, or the content of the compounded pectin is more than 0.0% and less than 1.0%, or the content of the mixture of the compounded chitosan and the pectin is more than 0.1% and less than 6%, and the balance of the refined water is added, and the pH value is adjusted to be 5.5-7.

Fifth embodiment

In a fifth embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting, and eliminating infection from fine airborne particulate matter that is contaminated by unwanted microorganisms in the form of a portable oral spray. In the method, deoxyribonucleic acid (DNA) is selected from sodium DNA, a humectant, an antimicrobial agent and ethanol are added, or water-soluble chitosan is added, or pectin is replaced, or a mixture of chitosan and pectin and refined water are added.

In the embodiment, the content of the sodium deoxyribonucleate is more than 0.08% and less than 2.0%, the content of the antimicrobial agent is more than 0.01% and less than 2.0%, the content of the humectant is more than 6.0% and less than 20%, the content of the ethanol is more than 2% and less than 25%, or the content of the water-soluble chitosan is more than 0.1% and less than 5%, or the content of the pectin is more than 0.0% and less than 1.0%, or the content of the mixture of the chitosan and the pectin is more than 0.1% and less than 6%, and the balance is prepared with refined water, and the pH value is adjusted to be 5.5-7.

In the embodiment, the sodium deoxyribonucleic acid is extracted from fish, has a molecular weight of more than 30kDa, has negative charges, and has strong activity and effect of adsorbing condensed molecules. Sodium deoxyribonucleate is used as a main active ingredient for realizing the absorption, agglomeration and inhibition of harmful microorganisms and the activity thereof in the fine particulate matters; the added antimicrobial agent component is extracted from natural animals and plants, and can kill harmful microorganisms once invading and contacting mucosa or quickly obstruct and interfere the propagation and the diffusion of the harmful microorganisms, thereby effectively inhibiting the harmful microorganism infection; or water-soluble chitosan or pectin or a mixed component of the water-soluble chitosan and the pectin is added to enhance and stabilize the performance of harmful microorganisms in the adhered particles; adding ethanol to enhance antibacterial effect and regulate preparation; adding humectant to stabilize and adjust the structural characteristics, action state and environment of each component, prolong the barrier action time, maintain the optimum mucosa affinity state, and enhance the effect and effect of blocking harmful microorganisms in fine particulate matters such as adhesion and coagulation; adding refined water to dilute each active ingredient to the optimal active concentration.

In the embodiment, the spraying mode is adopted to directly spray the spraying agent on the mucous membranes of the throats and the mouths of human bodies. The spraying amount is adjusted according to the spraying position and the environmental climate, and is generally more than 0.01ml and less than 0.5 ml. The barrier effect can last for 2-6 hours at the sprayed part of the mucosa in an unwashed state.

Under the action of the embodiment, the oral cavity inhalation device can quickly and effectively prevent harmful microorganisms in fine particulate matters in the air from invading and interfering, inhibit and relieve allergy, infection and other pathological reactions caused by harmful microorganism inhalation invasion in the fine particulate matters in the air, which are difficult to solve by other similar products and even medicaments, and has good effects of preventing virus bacteria and smoke and inhibiting the stimulation of virus bacteria and smoke to the throat. The colorless, odorless and invisible liquid barrier film cover can be formed. Is safe and has no side effect. Can replace most masks. The mask used as the medium and the test result show that when the blocking agent is sprayed, the blocking amount of the particles is about more than 1 time of that of a common mask or a mask added with distilled water, and the amount of the residual particles after one-time blocking is less than half of that of the common mask.

Sixth embodiment

In a sixth embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting and eliminating infection caused by harmful microorganism invasion in fine particulate air in the form of mouthwash. In the method, deoxyribonucleic acid (DNA) is selected from sodium DNA, a humectant, an antimicrobial agent and ethanol are added, or water-soluble chitosan is added, or pectin is replaced, or a mixture of chitosan and pectin is replaced; and refined water.

In the embodiment, the gargling mode is adopted to act on the mucous membrane of the throat in the oral cavity of the human body. The dosage can be adjusted according to gargle requirement. The barrier effect can last for 2-6 hours at the mucous membrane adhesion site in an unwashed state. Or can be rinsed to directly remove fine particulate matter in oral cavity and throat.

Seventh embodiment

In a seventh embodiment, a method is provided for rapidly and effectively blocking, stopping, inhibiting, and eliminating infection caused by infestation of fine airborne particles by harmful microorganisms in the form of small-particle throat drops with edible candy as a carrier. In the method, deoxyribonucleic acid (DNA) is sodium DNA, an antimicrobial agent is added, an edible humectant additive component is added, fructose and pectin are added, and an edible saccharification and forming component is added.

In the described embodiment, the sodium deoxyribonucleate is present in an amount greater than 0.08% and less than 3.5%, the antimicrobial is present in an amount greater than 0.01% and less than 2.0%, the edible humectant ingredients are present in an amount greater than 2.0% and less than 10.0%, and the balance is fructose and pectin and edible saccharifying and forming ingredients.

In the embodiment, the sodium deoxyribonucleic acid is extracted from refined components of fish, has a molecular weight of more than 30kDa, has negative charges, has strong activity and effect of adsorbing condensed molecules, and is a main active component for realizing the adsorption, condensation and inhibition of fine particles and the activity thereof; the added antimicrobial agent component is extracted from natural animals and plants, and can kill harmful microorganisms once invading and contacting mucosa or quickly obstruct and interfere the propagation and the diffusion of the harmful microorganisms, thereby effectively inhibiting the harmful microorganism infection; the additive is added with the edible humectant to stabilize and adjust the structural characteristics, action state and environment of each component, prolong the barrier action time, maintain the optimal mucosa affinity state, and strengthen the action and effect of blocking fine particles such as adhesion and agglomeration. The fructose pectin is obtained from natural fruit, and can enhance and stabilize the performance of adhering particulate matter and regulate sweet taste. The addition of edible saccharification and molding components can adjust the action state and taste of each component.

In the embodiment, the buccal way of the lozenge is adopted to improve the action environment of the blocking agent and greatly prolong the release time and action effect of the action components. Is particularly suitable for pregnant women and old and young patients who are inconvenient to use the spray mode.

Under the action of the embodiment, the oral cavity throat allergy, infection and other pathological reactions caused by inhalation and invasion of harmful microorganism particles in air fine particles, which are difficult to solve by other similar products and even medicaments, can be quickly and effectively blocked, and the oral cavity throat allergy, infection and other pathological reactions are inhibited and relieved, so that the oral cavity throat allergy, infection and other pathological reactions have good effects of blocking virus bacteria and smoke and inhibiting the stimulation of virus bacteria and smoke to the throat.

Eighth embodiment

In an eighth embodiment, a method for rapidly and effectively blocking, stopping, inhibiting and eliminating infection caused by invasion of fine particulate matters in the air in the form of a care product with the artificial nose hair nasal plug as a carrier and the performance of the care product are combined into a whole is provided. In the method, deoxyribonucleic acid (DNA) is selected from sodium DNA, a humectant, an antimicrobial agent, ethanol, water-soluble chitosan, pectin or a mixture of chitosan and pectin and refined water are added. The proportion of the components is in accordance with the proportion of various embodiments already described.

In the embodiment, on the premise of not hindering the normal breathing of the nasal cavity, the effect of the blocking agent on blocking, inhibiting and killing harmful microorganism particles in fine particles in the air through the nose can be further improved by overlapping the air filtering device in the nasal cavity, such as the artificial vibrissa nasal obstruction applied with the blocking agent, on the breathing channel.

The embodiments described in the specification are only preferred embodiments of the present invention, and the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit the present invention. Those skilled in the art can obtain technical solutions through logical analysis, reasoning or limited experiments according to the concepts of the present invention, and all such technical solutions are within the scope of the present invention.

Claims

1. A barrier agent for inhibiting infection by harmful microorganisms in fine particulate matter in the air, comprising: deoxyribonucleic acid, a humectant and an antimicrobial agent, wherein the barrier agent is directly applied to the skin, a mucosal surface or a carrier attached to the skin in a spraying or immersion mode, and the deoxyribonucleic acid meets the following weight ratio: deoxyribonucleic acid is more than or equal to 0.2 percent and less than or equal to 3.5 percent.

2. A barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein said deoxyribonucleic acid is sodium deoxyribonucleic acid.

3. The barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein said humectant and said antimicrobial agent satisfy the following weight ratio: the humectant is more than or equal to 2.0 percent and less than or equal to 20 percent; 0.01 percent to 2 percent of antimicrobial agent.

4. The barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein the barrier agent further comprises pectin satisfying the following weight ratios: pectin is more than or equal to 0.05 percent and less than or equal to 3.5 percent.

5. The barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein the barrier agent further comprises water-soluble chitosan, and the water-soluble chitosan satisfies the following weight ratio: the water-soluble chitosan is more than or equal to 0.1 percent and less than or equal to 8 percent.

6. The barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein the barrier agent further comprises ethanol, and the ethanol satisfies the following weight ratio: ethanol is more than or equal to 2.0 percent and less than or equal to 25 percent.

7. The barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein the barrier agent further comprises butanediol, the butanediol satisfying the following weight ratio: butanediol is more than or equal to 1.2 percent and less than or equal to 20 percent.

8. A barrier agent for inhibiting infection by harmful microorganisms in fine air particles according to claim 1, wherein said antimicrobial agent is an antimicrobial agent extracted from a natural plant.

9. A barrier agent for inhibiting the infection of harmful microorganisms in fine air particles according to any one of claims 1 to 8, wherein the barrier agent is sprayed on the inner wall of the oral cavity or nostrils, or is attached to a mask or a nasal plug by means of a spray or an immersion liquid, or is directly sprayed on the air or the surface of an object which may be contaminated by harmful microorganisms.