CN105486888A - Transcranial direct current stimulation and laser Doppler velocity measurement integrated device - Google Patents
Transcranial direct current stimulation and laser Doppler velocity measurement integrated device Download PDFInfo
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- CN105486888A CN105486888A CN201510860331.7A CN201510860331A CN105486888A CN 105486888 A CN105486888 A CN 105486888A CN 201510860331 A CN201510860331 A CN 201510860331A CN 105486888 A CN105486888 A CN 105486888A
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- condenser lens
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- optical splitter
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
- G01P5/26—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the direct influence of the streaming fluid on the properties of a detecting optical wave
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S17/00—Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
- G01S17/02—Systems using the reflection of electromagnetic waves other than radio waves
- G01S17/50—Systems of measurement based on relative movement of target
- G01S17/58—Velocity or trajectory determination systems; Sense-of-movement determination systems
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Abstract
The invention provides a transcranial direct current stimulation and laser Doppler velocity measurement integrated device. The device comprises a stimulation signal system and a velocity measurement system. The stimulation signal system is formed by a direct current stimulator, a stimulation isolator, an anode electrode slice and a cathode electrode slice. The velocity measurement system is formed by a laser, an optical splitter, a focusing lens A, a focusing lens B, a reflective mirror, a photoelectric detector, a preamplifier and a computer. The stimulation signal system is used for carrying out direct current stimulation on the head of an animal; and the velocity measurement system is used for measuring the cerebral blood flow velocity of the head of the animal. The integrated device has the advantages of safe and simple operation and reasonable design and the like.
Description
Technical field
The present invention relates to stimulation and testing equipment, especially a kind ofly galvanic current stimulation is carried out to animal brain and detects the device of velocity of blood flow.
Background technology
Electro photoluminescence all obtains applying more and more widely in the cerebral disorders therapeutic processes such as nervous system research and epilepsy, Parkinson, alzheimer's disease.Be a kind of Noninvasive through cranium galvanic current stimulation (transcranialdirectcurrentstimulation, tDCS), utilize low intensity direct current to regulate the technology of Cortical Neurons electrical activity.TDCS is made up of anode and negative electrode two surface electrodes, acts on cerebral cortex with faint polarization direct current.Research shows that anode excitation can strengthen the neuronic excitability of stimulation location usually, and negative electrode stimulates and then reduces the neuronic excitability of stimulation location.Laser Doppler vibration refers to and utilizes laser doppler to measure fluid movement velocity, the advantages such as spatial resolution is high, dynamic response is fast, measurement range is wide, non-cpntact measurement that it has.
The blood flow situation of change of cerebral vessels under researching DC electro photoluminescence effect, for analysis neural blood vessel coupling important in inhibiting.As follows in correlation technique, the patent No. is the patent document of 200880105399.2, describes a kind of stimulating apparatus, although this device can stimulate the motor area of cerebral cortex accurately, can not realize the measurement to the change of stimulation location blood flow.And number of patent application is the patent document of CN200410009261.6, describe a kind of self-mixed interference Doppler anemometer based on two-frequency laser, although this device is that a kind of compact conformation is simple, cost performance is high, and be easy to the speed measuring device realizing velocity reversal identification, but this device can not carry out through cranium galvanic current stimulation while carrying out measuring blood flow velocity.
In sum, for overcoming deficiency and the defect of prior art, the present invention proposes a kind of device that can carry out CBFV measurement real-time when galvanic current stimulation can realize again stimulating.
Summary of the invention
The object of the invention is to provide a kind of and manipulates conveniently, rational in infrastructure, the laser Doppler speed measuring device through cranium galvanic current stimulation that simultaneously can carry out galvanic current stimulation and brain blood flow measurement.
For achieving the above object, have employed following technical scheme: device of the present invention comprises stimulus signal system and velocity-measuring system; Stimulus signal system is made up of direct current stimulator, stimulation isolator, anode electrode film, cathode electrode sheet, the output terminal of direct current stimulator is connected with the signal input part of stimulation isolator by data line, the anode output end of stimulation isolator is connected with anode electrode film by wire, and the cathode end of stimulation isolator is connected with cathode electrode sheet by wire; Velocity-measuring system is made up of laser instrument, optical splitter, condenser lens A, condenser lens B, reflective mirror, photodetector, prime amplifier and computing machine, laser instrument is connected with optical splitter by optical fiber, the laser induced breakdown that laser instrument sends by optical splitter is the aplanatic parallel beam of two bundles, and two parallel beams form focus point by condenser lens A; One piece of reflective mirror is installed in position between optical splitter and condenser lens A, two light beams that the minute surface of this reflective mirror and optical splitter decomposite are non-parallel contactless state, the reflected light path of reflective mirror is installed condenser lens B, in the below of condenser lens B, photodetector is installed, the receiving transducer of described photodetector overlaps with the focus point of condenser lens B, the output terminal of photodetector is connected with the input end of prime amplifier by data line, and the output terminal of prime amplifier is connected with computing machine by data line.
The course of work is roughly as follows:
Anode electrode film in stimulus signal system is attached on the skull of toy, and cathode electrode sheet is affixed on skin on rear side of toy neck, or also can by the two reversing of position.The signal that direct current stimulator produces is delivered to anode electrode film and cathode electrode sheet through stimulation isolator; Electric current directly through cranium galvanism flows into from cathode electrode sheet outflow from anode electrode film, and electric current flows through the cerebral cortex of toy, causes brain neuroblastoma physiological change, reaches stimulation object.In velocity-measuring system, laser instrument, optical splitter, condenser lens A, condenser lens B, reflective mirror, photodetector, prime amplifier and computing machine composition Laser Doppler Velocimeter, collected by photodetector by the Doppler signal of the haemocyte of laser probe, through prime amplifier, signal is amplified again, Signal transmissions after amplification processes to computing machine, and the relation according to speed and Doppler frequency obtains CBFV.
Compared with prior art, tool of the present invention has the following advantages: manipulate safe and simple, reasonable in design, can carry out the measurement through cranium galvanic current stimulation and CBFV simultaneously.
Accompanying drawing explanation
Fig. 1 is structured flowchart of the present invention.
Drawing reference numeral: 1-computing machine, 2-prime amplifier, 3-photodetector, 4-condenser lens B, 5-laser instrument, 6-optical splitter, 7-reflective mirror, 8-condenser lens A, 9-direct current stimulator, 10-stimulation isolator, 11-anode electrode film, 12-cathode electrode sheet, 13-rat head.
Embodiment
Below in conjunction with accompanying drawing, the present invention will be further described:
In structured flowchart of the present invention as shown in Figure 1, for rat head 13, the present invention will be described, and device of the present invention comprises stimulus signal system and velocity-measuring system; Stimulus signal system is made up of direct current stimulator 9, stimulation isolator 10, anode electrode film 11, cathode electrode sheet 12, the output terminal of direct current stimulator is connected with the signal input part of stimulation isolator by data line, the anode output end of stimulation isolator is connected with anode electrode film by wire, and the cathode end of stimulation isolator is connected with cathode electrode sheet by wire; Velocity-measuring system is made up of laser instrument 5, optical splitter 6, condenser lens A8, condenser lens B4, reflective mirror 7, photodetector 3, prime amplifier 2 and computing machine 1, laser instrument is connected with optical splitter by optical fiber, the laser induced breakdown that laser instrument sends by optical splitter is the aplanatic parallel beam of two bundles, and two parallel beams form focus point by condenser lens A; One piece of reflective mirror is installed in position between optical splitter and condenser lens A, two light beams that the minute surface of this reflective mirror and optical splitter decomposite are non-parallel contactless state, the reflected light path of reflective mirror is installed condenser lens B, in the below of condenser lens B, photodetector is installed, the receiving transducer of described photodetector overlaps with the focus point of condenser lens B, the output terminal of photodetector is connected with the input end of prime amplifier by data line, and the output terminal of prime amplifier is connected with computing machine by data line.
Wherein, described laser instrument is He-Ni laser instrument.
Described photodetector is the S8703 type photodetector of Japanese Hamamatsu company.
Described prime amplifier is the C11184 type prime amplifier of Japanese Hamamatsu company.
Described direct current stimulator is the JL-B type direct current stimulator of Shanghai Jia Longjiao instrument factory.
Described stimulation isolator is the JL-E type stimulation isolator of Shanghai Jia Longjiao instrument factory.
Described optical splitter, condenser lens, condenser lens, reflective mirror all adopt Beijing to stand upright the relevant device of Han Guang instrument company.
Specific implementation method step is as follows:
(1) rat is placed on stereotaxic apparatus, fix rat head, the part skull of rat head is removed by operation of opening cranium, remove dura mater, retain complete blood vessel, anode electrode film is pasted onto the position near blood vessel, cathode electrode sheet is pasted onto the position away from blood vessel, the distance between two electrode slices is 5cm;
(2) stereotaxic apparatus fixing rat is placed on immediately below condenser lens A, the position of adjustment stereotaxic instrument and condenser lens A, so that the focus of condenser lens A can focus on head vessel position, the angle of adjustment stereotaxic instrument and condenser lens A, so that condenser lens and head vascularization pitch angle;
(3) configuring direct current egersimeter produces the signal parameter needed for galvanic current stimulation;
(4) signal that direct current stimulator produces is delivered to anode electrode film and cathode electrode sheet through stimulation isolator;
(5) electric current of tDCS flows into from anode electrode film and flows out from cathode electrode sheet, and electric current flows through cerebral cortex, causes brain neuroblastoma physiological change;
(6) while galvanic current stimulation, open laser switch, configuration laser parameter, light source is decomposed into aplanatic two bundle sources of parallel light through optical splitter by the laser that laser instrument sends, two bundle sources of parallel light is focused in its point of intersection by condenser lens A, its focus just in time head tissue blood vessel and with vascularization angle;
(7) light source irradiation is after head blood vessel, and after the scattering process of blood flow, scattered light is irradiated on a mirror by condenser lens A again, and scattered light reflects and focuses on photodetector place by condenser lens B by reflective mirror;
(8), after photoelectric detector to scattered light signal, scattered light signal is converted to corresponding electric signal;
(9) photodetector is by electrical signal transfer to prime amplifier, after the amplification of prime amplifier, passes to computing machine;
(10), after computing machine receives electric signal, the host computer in computing machine is to Electric signal processing thus obtain the CBFV at galvanic current stimulation position.
Above-described embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determines.
Claims (1)
1. through cranium galvanic current stimulation and a laser Dppler veloicty measurement integrated apparatus, it is characterized in that: described device comprises stimulus signal system and velocity-measuring system; Stimulus signal system is made up of direct current stimulator, stimulation isolator, anode electrode film, cathode electrode sheet, the output terminal of direct current stimulator is connected with the signal input part of stimulation isolator by data line, the anode output end of stimulation isolator is connected with anode electrode film by wire, and the cathode end of stimulation isolator is connected with cathode electrode sheet by wire; Velocity-measuring system is made up of laser instrument, optical splitter, condenser lens A, condenser lens B, reflective mirror, photodetector, prime amplifier and computing machine, laser instrument is connected with optical splitter by optical fiber, the laser induced breakdown that laser instrument sends by optical splitter is the aplanatic parallel beam of two bundles, and two parallel beams form focus point by condenser lens A; One piece of reflective mirror is installed in position between optical splitter and condenser lens A, two light beams that the minute surface of this reflective mirror and optical splitter decomposite are non-parallel contactless state, the reflected light path of reflective mirror is installed condenser lens B, in the below of condenser lens B, photodetector is installed, the receiving transducer of described photodetector overlaps with the focus point of condenser lens B, the output terminal of photodetector is connected with the input end of prime amplifier by data line, and the output terminal of prime amplifier is connected with computing machine by data line.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510860331.7A CN105486888A (en) | 2015-11-30 | 2015-11-30 | Transcranial direct current stimulation and laser Doppler velocity measurement integrated device |
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| CN201510860331.7A CN105486888A (en) | 2015-11-30 | 2015-11-30 | Transcranial direct current stimulation and laser Doppler velocity measurement integrated device |
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2015
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Patent Citations (15)
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|---|---|---|---|---|
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| CN2716850Y (en) * | 2004-05-27 | 2005-08-10 | 中国科学院长春光学精密机械与物理研究所 | A passive dual light-path laser Doppler velocimeter |
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Application publication date: 20160413 |