CN105481872B - A kind of method of constant temperature gradient series connection extraction active components of plants - Google Patents
A kind of method of constant temperature gradient series connection extraction active components of plants Download PDFInfo
- Publication number
- CN105481872B CN105481872B CN201510858904.2A CN201510858904A CN105481872B CN 105481872 B CN105481872 B CN 105481872B CN 201510858904 A CN201510858904 A CN 201510858904A CN 105481872 B CN105481872 B CN 105481872B
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- CN
- China
- Prior art keywords
- extraction
- extractor
- series connection
- extract solution
- temperature
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- 238000000605 extraction Methods 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 23
- 238000009413 insulation Methods 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 241000196324 Embryophyta Species 0.000 claims description 14
- 240000005819 Magnolia denudata Species 0.000 claims description 14
- 235000016094 Magnolia denudata Nutrition 0.000 claims description 14
- DEDOPGXGGQYYMW-UHFFFAOYSA-N molinate Chemical compound CCSC(=O)N1CCCCCC1 DEDOPGXGGQYYMW-UHFFFAOYSA-N 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000002002 slurry Substances 0.000 claims description 9
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000005360 mashing Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 8
- 238000011084 recovery Methods 0.000 abstract description 6
- 238000000638 solvent extraction Methods 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 244000269722 Thea sinensis Species 0.000 description 10
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 235000009569 green tea Nutrition 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 description 5
- 235000013824 polyphenols Nutrition 0.000 description 5
- 239000003643 water by type Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 238000003809 water extraction Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- HATRDXDCPOXQJX-UHFFFAOYSA-N Thapsigargin Natural products CCCCCCCC(=O)OC1C(OC(O)C(=C/C)C)C(=C2C3OC(=O)C(C)(O)C3(O)C(CC(C)(OC(=O)C)C12)OC(=O)CCC)C HATRDXDCPOXQJX-UHFFFAOYSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229930009674 sesquiterpene lactone Natural products 0.000 description 1
- 150000002107 sesquiterpene lactone derivatives Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
Description
Claims (4)
- A kind of 1. method of constant temperature gradient series connection extraction active components of plants, it is characterised in that this method is to take 3-5 extractor Series connection, the plant material for being intended to be extracted are respectively implanted in each extractor by tank number decile;Added in the first extractor Extractant, heating and thermal insulation extraction, then the extract solution of the first extractor is drawn into the second extractor as Extraction solvent, heating To previous extraction temperature, insulation extraction same time, the rest may be inferred, until last extractor is protected under foregoing extraction temperature Temperature extraction same time, obtained extract solution centrifugal filtration;Then extractant is added in the material residue of the first extractor by foregoing Method repeats series connection extraction 1-2 times, obtained extract solution centrifugal filtration, the filtrate that merging is each time under foregoing extraction temperature;Wherein, above-mentioned plant material is wide yulan fresh leaf, and active component is parithenolide, the extraction added in the first extractor Agent is methanol, ethanol or the amylalcohol of 80%-95% volumetric concentrations, and extractant adds 8ml extractants by the wide yulan fresh leaf slurry/material residues of 1g Ratio add, Extracting temperature be 65-70 DEG C, extraction time 20-30min.
- 2. the method for a kind of constant temperature gradient series connection extraction active components of plants as claimed in claim 1, it is characterised in that described Wide yulan fresh leaf is inserted in extractor again after being handled as follows:The mashing of wide yulan fresh leaf is broken, by 1g leaves slurry plus 2mL volumes Concentration is the ratio of 80%-95% polarity organic reagent, and polarity organic reagent is added in leaf slurry, and cold soaking steeps 12- under normal temperature 24h。
- 3. the method for a kind of constant temperature gradient series connection extraction active components of plants as claimed in claim 2, it is characterised in that described Polarity organic reagent is methanol, ethanol or amylalcohol.
- 4. the method for a kind of constant temperature gradient series connection extraction active components of plants as claimed in claim 1, it is characterised in that described Filtering is using tripodia centrifugation cloth bag 200 mesh filtering.
Priority Applications (1)
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CN201510858904.2A CN105481872B (en) | 2015-12-01 | 2015-12-01 | A kind of method of constant temperature gradient series connection extraction active components of plants |
Applications Claiming Priority (1)
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CN201510858904.2A CN105481872B (en) | 2015-12-01 | 2015-12-01 | A kind of method of constant temperature gradient series connection extraction active components of plants |
Publications (2)
Publication Number | Publication Date |
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CN105481872A CN105481872A (en) | 2016-04-13 |
CN105481872B true CN105481872B (en) | 2018-01-09 |
Family
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Family Applications (1)
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CN201510858904.2A Active CN105481872B (en) | 2015-12-01 | 2015-12-01 | A kind of method of constant temperature gradient series connection extraction active components of plants |
Country Status (1)
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CN (1) | CN105481872B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109609277A (en) * | 2019-01-24 | 2019-04-12 | 河北省农林科学院经济作物研究所 | A kind of continuous extracting device and technique |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1472932B1 (en) * | 2002-02-05 | 2008-04-23 | Kao Corporation | Process for producing green tea polyphenol |
US20060222722A1 (en) * | 2005-03-30 | 2006-10-05 | Roberts Stephen C | Sublingual methods of treatment to alleviate or prevent arthritis |
US20110117070A1 (en) * | 2005-04-19 | 2011-05-19 | Aurora Sheena K | Compositions and methods for treating headache |
CN101190258A (en) * | 2007-05-30 | 2008-06-04 | 北京星昊医药股份有限公司 | Total sesquiterpene lactone extract containing rich parthenolide and preparation method and application thereof |
CN102863452B (en) * | 2011-07-06 | 2015-05-20 | 天津尚德药缘科技有限公司 | Method for preparing parthenolide originated from magnolia delavayi, magnolia liliiflora and magnolia denudate |
CN103170157A (en) * | 2013-03-07 | 2013-06-26 | 康宝莱蕾硕(湖南)天然产物有限公司 | Continuous countercurrent extraction technology, and extraction tanks and extraction system thereof |
CN103920305B (en) * | 2014-04-23 | 2015-12-02 | 柳秦桥 | A kind of method of pot group type counter-flow extraction Chinese caterpillar fungus |
CN103999975A (en) * | 2014-05-22 | 2014-08-27 | 青海阿如拉藏医药研究开发有限公司 | Preparation method for instant Tibetan tea |
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2015
- 2015-12-01 CN CN201510858904.2A patent/CN105481872B/en active Active
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CN105481872A (en) | 2016-04-13 |
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TR01 | Transfer of patent right |
Effective date of registration: 20180411 Address after: 415500 No. 1 Middle School Road, Lixian County, Hunan province. Patentee after: Hunan GuanYuan Biotechnology Co., Ltd. Address before: 410001 No. 1, international enterprise center, 188 environmental protection road, Yuhua District, Hunan, Changsha A301 Patentee before: Liu Hanyi |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210514 Address after: Room 505, 5th floor, building B, Hunan Jindan science and technology venture building, 1 XIONGTIAN Road, Longping hi tech park, Furong district, Changsha City, Hunan Province, 410000 Patentee after: Changsha Huirui Bio-technology Co.,Ltd. Address before: 415500 No.1, Zhongxue Road, Guanyuan wharf neighborhood committee, Guanyuan Township, Li County, Hunan Province Patentee before: HUNAN GUANYUAN BIOTECHNOLOGY Co.,Ltd. |