CN105466891A - Double-modulation-mode self-precision optical fiber surface plasma resonance biochemical detection sensor - Google Patents
Double-modulation-mode self-precision optical fiber surface plasma resonance biochemical detection sensor Download PDFInfo
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- CN105466891A CN105466891A CN201510818101.4A CN201510818101A CN105466891A CN 105466891 A CN105466891 A CN 105466891A CN 201510818101 A CN201510818101 A CN 201510818101A CN 105466891 A CN105466891 A CN 105466891A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
- G01N2021/5903—Transmissivity using surface plasmon resonance [SPR], e.g. extraordinary optical transmission [EOT]
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Abstract
The invention provides a double-modulation-mode self-precision optical fiber surface plasma resonance biochemical detection sensor and belongs to the technical field of optical fiber sensing. The sensor adopts a terminal reflective sensing structure. According to the invention, the end face of a fiber core of a plastic-clad multimode fiber with the core diameter being 400-600 m and numerical aperture being not less than 0.24 is polished, and the polished fiber core end-face undergoes sputtering of more than 200 nm of a silver film to form a reflecting mirror surface; and two sections of coating layers and cladding layers on the multimode fiber are stripped to form two sensing channels of 5-10 mm long. Gold nano-spheres are fixed on the surface of one sensing channel, and silver-ITO two-layered films are sputtered in the order of silver-ITO onto the surface of the other sensing channel, wherein thickness of the silver layer is 35-45 nm, and thickness of the ITO layer is 5-15 nm. By a simple sputter coating technology and a layer-by-layer self-assembly method, double-modulating signal demodulation is realized, and precision influence generated by a single modulation mode is avoided.
Description
Technical field
The invention belongs to technical field of optical fiber sensing, relate to a kind of double modulation optical fiber surface plasmon resonance body biochemistry detection sensor had from precise function.
Background technology
Binary channels biochemical sensor many employings prism coupling structure of current employing Surface Plasmon Resonance Technology, such sensor construction is complicated, volume is comparatively large, cost of manufacture is expensive, is difficult to form widespread use in the industrial production; Though have the surface plasma resonance sensor of multiple layer metal alternate films system to occur at present, but mostly be single-pass configuration, easily be subject to the impact of temperature or the factor such as the change of sample solution bulk refractive index and sample volatilization on the sensing detection of biological sample, sensor does not possess compensation ability, and the accuracy of detection is poor.And the mode of the double channel optical fiber sensor many employings plated film modulation wavelength based on Surface Plasmon Resonance Technology occurred at present, modulation system is single, detects degree of accuracy poor.
Summary of the invention
The object of this invention is to provide a kind of double modulation pattern optical fiber surface plasma resonance biochemical detecting sensor had from precise function, signal receiving for two passages is replaced without the need to carrying out complicated target to sensing surface and repeats alternate plating mode, adopts simple coating process and autonomous dress mode to realize; Adopt optical patchcord signal transmission, avoid the labyrinth of prism coupled type surface plasma resonance sensor; Independently dress method fixes nano gold spherical at a sensing passage layer by layer, the sensitivity that two passages respond sample refractive index and temperature variation is realized by the Coating Materials, the coating film thickness that regulate and control plated film sensing passage fibre core surface, wavelength and intensity debud mode occur simultaneously, thus the interference that temperature or sample body variations in refractive index cause detection in biochemistry detection can be avoided, realize sensor from precise function, improve detect degree of accuracy.
Technical scheme of the present invention:
A kind of double modulation pattern is from accurate optical fiber surface plasmon resonance body biochemical sensor, and this sensor adopts end reflection formula sensing arrangement, and adopt plastic envelope multimode optical fiber, its core diameter is 400-600 μm, numerical aperture is not less than 0.24; The core end surface sputtering thickness of the plastic envelope multimode optical fiber of end face polishing is the silverskin of more than 200nm, forms mirror surface; At close mirror surface end, peel off two sections of coats on plastic envelope multimode optical fiber and covering, form two sensing passages, the length of two sensing passages is 5mm-10mm, and two interchannels have appropriate intervals; Nano gold spherical is fixed by LBL self-assembly method in a sensing passage surface, and the diameter of nano gold spherical is 15-30nm; Another sensing passage surface uniform sputter coating, be the silver-ITO duplicature of 50nm according to the sequential sputtering gross thickness of silver-tin indium oxide (ITO), wherein silver thickness is 35-45nm, and ITO layer is 5-15nm; The spectral separation of two passages is made by the Coating Materials of regulation and control plated film channel surface, coating film thickness, two passages all have response sensitivity to temperature and sample solution refractive index, plated film passage has wavelength-modulated effect to different refractivity solution, nano gold spherical sensing passage then has intensity modulated effect, make this double modulation sensor standby to temperature and refractive index from precise function, realize more accurate sensing detection.
The multimode optical fiber wire jumper of Y type is adopted to carry out the coupled transfer of signal.The wide spectrum optical that optical fiber source is launched enters double modulation self compensation optical fiber surface plasmon resonance body biochemical sensor through of y-type optical fiber wire jumper, at sensing passage fibre core and metallic film interface excitation surface plasma body resonant vibration, transducing signal, at reflection end face generation mirror-reflection, is coupled on spectrometer CCD through wire jumper one and detects.
Effect of the present invention and benefit are: adopt comparatively simple magnetron sputtering membrane process and Chemical self-assembly method to achieve the demodulation of double modulated signal, make the spectral separation of two passages by the Coating Materials, the coating film thickness that regulate and control plated film passage fibre core surface and to temperature and sample refractive index, all there is higher response sensitivity, realize two kinds of modes of temperature and sample refractive index are modulated, thus made sensor standby from precise function.Sensor performance is stablized, technique is simple, cost is lower and have higher degree of accuracy to sensing detection.
Accompanying drawing explanation
Accompanying drawing is that double modulation is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor construction schematic diagram.
In figure: 1 nano-gold film; 2 silver medal-ITO duplicatures; 3 mirror surfaces.
Embodiment
The specific embodiment of the present invention is described in detail below in conjunction with technical scheme and accompanying drawing.
The present invention is using surface plasma body resonant vibration as sensing principle, and the generation of this effect depends on wide spectrum light source, and object is the sensing detection realizing wavelength-modulated and intensity modulated mode in a fiber.In order to strengthen signal intensity, optimize sensing capabilities, large aperture multimode optical fiber selected by the optical fiber making sensor.The optical fiber that the present invention adopts is fibre core, covering, coat diameter are respectively 400 μm, 430 μm, 730 μm, the large aperture plastic-clad optical fiber of numerical aperture 0.37.
Preparation process of the present invention is as follows:
(1) first get one section of long plastic envelope multimode optical fiber of 60mm, in the position apart from fiber end face 10mm and 20mm, use optical fiber pincers to peel off the optical fiber coating of 5mm respectively.
(2) by the sand paper polishing of fiber core end face, and be coated with the silverskin of 300nm thickness with coating machine, form mirror surface.
(3) encapsulate mirror surface after epoxy resin A, B glue 1:1 ratio being mixed, prevent from causing damage to mirror surface in use procedure.
(4) fibre cladding peelling off the sensing passage of coat is removed.Adopt acetone soln to soak sensing passage, optic fibre plastics covering is come off completely.
(5) one of them channel surface is by LBL self-assembly method, after with the process of Piranha washing lotion, alternate immersion in polymer P DDA, PSS and PAH polymer solution, often kind of polymer solution soaks 10 minutes, being immersed in diameter is afterwards in the nano gold spherical solution of 15-30nm 1 hour, completes the preparation of intensity modulated sensing passage.
(6) the plated film passage of sensor adopts 360 ° of mode plated films rotated in coating machine, makes Coating Materials uniform sputter to sensing passage all surfaces; Plated film sensing passage surface is the silver-ITO duplicature system of 50nm according to the sequential sputtering gross thickness that silver-ITO (tin indium oxide) replaces, and wherein silver thickness is 40nm, and ITO layer is 10nm, completes the preparation of wavelength-modulated sensing passage.
Claims (3)
1. double modulation pattern is from an accurate optical fiber surface plasmon resonance body biochemistry detection sensor, it is characterized in that, adopts end reflection formula sensing arrangement, adopt that core diameter is 300-600 μm, numerical aperture be not less than 0.24 optical fiber; The core end surface sputtering thickness of the optical fiber of end face polishing is the silverskin of more than 200nm, forms mirror surface; At close mirror surface end, peel off two sections of coats on plastic envelope multimode optical fiber and covering, form two sensing passages, the length of two sensing passages is 5mm-10mm, and two interchannels have appropriate intervals; A sensing passage surface is the gold goal of 15-30nm by LBL self-assembly method fixed diameter; Another sensing passage surface uniform sputter coating, be the silver-ITO duplicature of 50nm according to the sequential sputtering gross thickness of silver-tin indium oxide, wherein silver thickness is 35-45nm, and ITO layer is 5-15nm.
2. double modulation pattern according to claim 1 is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor, it is characterized in that, the surface plasma generation mechanism that this sensor adopts assemble nanometer material different from metal-coated membrane two kinds, intensity modulated and wavelength-modulated two kinds of modulating modes are simultaneously for biochemistry detection.
3. double modulation pattern according to claim 1 and 2 is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor, it is characterized in that, the diameter of described nano gold spherical is 15-30nm.
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| CN201510818101.4A CN105466891B (en) | 2015-11-23 | 2015-11-23 | Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor |
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| CN201510818101.4A CN105466891B (en) | 2015-11-23 | 2015-11-23 | Double modulation mode is from accurate optical fiber surface plasmon resonance body biochemistry detection sensor |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108535220A (en) * | 2018-07-17 | 2018-09-14 | 河南师范大学 | Wedge shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN109652752A (en) * | 2018-12-28 | 2019-04-19 | 北京信息科技大学 | The method crossed fiber end face and prepare fiber reflector is applied using ultrasonic wave melting |
| CN110044463A (en) * | 2019-04-28 | 2019-07-23 | 陕西师范大学 | A kind of sensing arrangement based on Fibre Optical Sensor |
| CN110672564A (en) * | 2019-10-22 | 2020-01-10 | 重庆理工大学 | Nano-gold shell LSPR (localized surface plasmon resonance) optode biosensor of graphene oxide fiber bragg grating |
| WO2022047847A1 (en) * | 2020-09-07 | 2022-03-10 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip and manufacturing method therefor, biosensing system including same, and use of biosensing system |
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| US20110069316A1 (en) * | 2009-09-22 | 2011-03-24 | National Chung Cheng University | Localized plasmon resonance sensing device and fiber optic structure |
| CN104020140A (en) * | 2014-06-05 | 2014-09-03 | 大连理工大学 | Dual-channel self-compensation optical fiber surface plasma resonance biochemical sensor |
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- 2015-11-23 CN CN201510818101.4A patent/CN105466891B/en active Active
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108535220A (en) * | 2018-07-17 | 2018-09-14 | 河南师范大学 | Wedge shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN108535220B (en) * | 2018-07-17 | 2024-02-27 | 河南师范大学 | Wedge-shaped tip nanostructure integrated optical fiber surface plasma resonance biochemical sensor |
| CN109652752A (en) * | 2018-12-28 | 2019-04-19 | 北京信息科技大学 | The method crossed fiber end face and prepare fiber reflector is applied using ultrasonic wave melting |
| CN109652752B (en) * | 2018-12-28 | 2021-02-19 | 北京信息科技大学 | Method for preparing optical fiber reflector by using ultrasonic fusion coating optical fiber end face |
| CN110044463A (en) * | 2019-04-28 | 2019-07-23 | 陕西师范大学 | A kind of sensing arrangement based on Fibre Optical Sensor |
| CN110672564A (en) * | 2019-10-22 | 2020-01-10 | 重庆理工大学 | Nano-gold shell LSPR (localized surface plasmon resonance) optode biosensor of graphene oxide fiber bragg grating |
| WO2022047847A1 (en) * | 2020-09-07 | 2022-03-10 | 科竟达生物科技有限公司 | Local surface plasmon resonance biochip and manufacturing method therefor, biosensing system including same, and use of biosensing system |
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