CN105457086B - Utilize the method for rhodium complex processing titania nanotube - Google Patents
Utilize the method for rhodium complex processing titania nanotube Download PDFInfo
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- CN105457086B CN105457086B CN201510793528.3A CN201510793528A CN105457086B CN 105457086 B CN105457086 B CN 105457086B CN 201510793528 A CN201510793528 A CN 201510793528A CN 105457086 B CN105457086 B CN 105457086B
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- rhodium complex
- titania nanotube
- rhodium
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 title claims abstract description 91
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 title claims abstract description 74
- 229910052703 rhodium Inorganic materials 0.000 title claims abstract description 68
- 239000010948 rhodium Substances 0.000 title claims abstract description 68
- 239000002071 nanotube Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000012545 processing Methods 0.000 title claims abstract description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000007787 solid Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000006228 supernatant Substances 0.000 claims abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 8
- 238000005119 centrifugation Methods 0.000 claims abstract description 7
- KKIGUVBJOHCXSP-UHFFFAOYSA-N 4-phenylthiosemicarbazide Chemical class NNC(=S)NC1=CC=CC=C1 KKIGUVBJOHCXSP-UHFFFAOYSA-N 0.000 claims description 19
- JDCLCNYVTXYZRH-UHFFFAOYSA-N C(C1=CC=CC=C1)=O.S1C=NC=C1 Chemical compound C(C1=CC=CC=C1)=O.S1C=NC=C1 JDCLCNYVTXYZRH-UHFFFAOYSA-N 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 235000019441 ethanol Nutrition 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 7
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 6
- 125000003963 dichloro group Chemical group Cl* 0.000 claims description 6
- 125000005909 ethyl alcohol group Chemical group 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene chloride Substances ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- WQIQNKQYEUMPBM-UHFFFAOYSA-N pentamethylcyclopentadiene Chemical compound CC1C(C)=C(C)C(C)=C1C WQIQNKQYEUMPBM-UHFFFAOYSA-N 0.000 claims description 6
- PZSJYEAHAINDJI-UHFFFAOYSA-N rhodium(3+) Chemical class [Rh+3] PZSJYEAHAINDJI-UHFFFAOYSA-N 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- -1 methyl cyclopentadienyl Chemical group 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 12
- 230000001093 anti-cancer Effects 0.000 abstract description 8
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 35
- 210000004027 cell Anatomy 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 6
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000004053 dental implant Substances 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- BKBWCGMJBPYPSD-SNAWJCMRSA-N C=C(/C=C/c(cc1)ccc1-c1ncc[s]1)C(C([N]1(P=C)[IH]C1)=S)=C Chemical compound C=C(/C=C/c(cc1)ccc1-c1ncc[s]1)C(C([N]1(P=C)[IH]C1)=S)=C BKBWCGMJBPYPSD-SNAWJCMRSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N deuterated chloroform Substances [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 150000003349 semicarbazides Chemical class 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/224—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials containing metals, e.g. porphyrins, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Cell strain | U2-OS | CNE-1 |
Embodiment 1 | 11.6 | 15.8 |
Embodiment 2 | 11.5 | 15.5 |
Embodiment 3 | 11.3 | 15.1 |
Embodiment 4 | 11.2 | 15.3 |
It is conventional | > 100 | > 100 |
4 days | 7 days | 10 days | |
Embodiment 1 | 0.21 | 0.51 | 1.58 |
Embodiment 2 | 0.20 | 0.52 | 1.55 |
Embodiment 3 | 0.19 | 0.57 | 1.59 |
Embodiment 4 | 0.19 | 0.52 | 1.55 |
It is conventional | 1.21 | 3.12 | 8.10 |
4 days | 7 days | 10 days | |
Embodiment 1 | 0.14 | 0.39 | 1.29 |
Embodiment 2 | 0.14 | 0.38 | 1.29 |
Embodiment 3 | 0.15 | 0.38 | 1.35 |
Embodiment 4 | 0.15 | 0.38 | 1.42 |
It is conventional | 0.06 | 0.18 | 0.54 |
Claims (5)
- A kind of 1. method using rhodium complex processing titania nanotube, which is characterized in that as follows including step:1) 3-6g4- (2- thiazolyls)-benzaldehyde is dissolved in 8-13ml absolute ethyl alcohols, and adds in 4- phenyl -3- thiosemicarbazides 1-2g, 60-70 DEG C are refluxed, and reaction 4-6h obtains micro- purple solution, are spin-dried for 1-2ml, add in 5-6ml ethyl alcohol and 5-6ml Normal hexane, it is to thiazole benzaldehyde contracting 4- phenyl -3- thiosemicarbazides with formula (1) that white crystal, which is precipitated,;2) it weighs to thiazole benzaldehyde contracting 4- phenyl -3- thiosemicarbazides 20-30mg and dichloro (pentamethylcyclopentadiene base) It closes rhodium (III) dimer 31-38mg and adds in CH2Cl26-7ml, stirring at normal temperature 6-7 hours, solution decompression is distilled to 1-2ml, quiet It puts and red solid is precipitated as the rhodium complex with formula (2), i.e. chlorine a pair of thiazole benzaldehyde contracting 4- phenyl -3- sulfo-aminos Urea First Five-Year Plan methyl cyclopentadienyl closes rhodium (III);3) it is the rhodium complex is soluble in water, stir evenly to obtain rhodium complex solution;4) titania nanotube is soaked in the rhodium complex solution, and it is molten that nitrogen is constantly filled with to the rhodium complex Liquid bottom 5-10 minutes, then microwave heating 20-30 seconds, the temperature of the microwave heating was 80-95 DEG C;5) it stands and is cooled to room temperature, be pressurized to 20-25Mpa, normal pressure is dropped to, then centrifuge 30-60 minutes after being kept for 2-3 minutes;6) supernatant after centrifugation is removed, layer solution is removed and solid is placed in 100-120 DEG C, be pressurized to 20-25Mpa, is kept 2-3 minutes, then drop to normal pressure, dry 20-26 hour.
- 2. the method for rhodium complex processing titania nanotube is utilized according to claim 1, which is characterized in that the step It is rapid 3) in the mass volume ratio of rhodium complex and water be 2-13g: 100ml.
- 3. the method for rhodium complex processing titania nanotube is utilized according to claim 1, which is characterized in that the step It is rapid 4) in titania nanotube caliber for 20-50nm, pipe range 150-500nm, addition is 1-5 parts by weight.
- 4. the method for rhodium complex processing titania nanotube is utilized according to claim 3, which is characterized in that the step It is rapid 5) in centrifugal speed be 3500-4500rpm.
- 5. the method for rhodium complex processing titania nanotube is utilized according to claim 4, which is characterized in that the step It is rapid 6) in remove the amount of supernatant be 0.6-0.8 times of total solution.
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CN201510793528.3A CN105457086B (en) | 2015-11-17 | 2015-11-17 | Utilize the method for rhodium complex processing titania nanotube |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104402940A (en) * | 2014-11-18 | 2015-03-11 | 广西中医药大学 | Rhodium complex as well as preparation method and application thereof |
CN104826159A (en) * | 2015-04-24 | 2015-08-12 | 湖北大学 | Medical titanium metal implant material and preparation method thereof |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104402940A (en) * | 2014-11-18 | 2015-03-11 | 广西中医药大学 | Rhodium complex as well as preparation method and application thereof |
CN104826159A (en) * | 2015-04-24 | 2015-08-12 | 湖北大学 | Medical titanium metal implant material and preparation method thereof |
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Effective date of registration: 20221227 Address after: 257091 Room 101, Building 5, Science and Technology Enterprise Accelerator, No. 17, Xinghuahe Road, Dongying Development Zone, Shandong Province Patentee after: Dongying Dongkai New Material Technology Research and Development Co.,Ltd. Address before: 257091 room 419, building a, Dongying Economic and Technological Development Zone Management Committee, No. 59, Fuqian street, Dongying District, Dongying City, Shandong Province Patentee before: Dongying dongkai New Material Industrial Park Co.,Ltd. |
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