CN105435208A - Traditional Chinese medicine preparation for treating breast hyperplasia and preparation method thereof - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating breast hyperplasia. The traditional Chinese medicine preparation is prepared from semen cassia, pipewort, leonurus, pseudo-ginseng, liquorice, fructus forsythiae, coptis chinensis, golden cypress, multiflora roses, artemisia anomala, nux vomica, pinellia ternate, rhizoma cynanchi stauntonii, tuber fleeceflower stems, gastrodia elata, Chinese yam, lilies, kadsura pepper stems, tetrapanax papyriferus, chingma abutilon seeds, rhizoma zingiberis, orange peel, lychee exocarp and the like. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation , has a quite good curative effect on breast hyperplasia disease and has the advantages of being good in course of treatment, low in cost, convenient to use and not prone to relapse. The traditional Chinese medicine preparation is based on a traditional Chinese medicine theory formula, medicine selection is reasonable, the effects of tonifying qi, supplementing blood, activating blood to dispersing blood stasis, relieving hardness and dispersing stasis and relieving swelling and pain and both symptoms and roots of the disease are treated. The traditional Chinese medicine preparation has the advantages of being strict in compatibility, mild in drug property and remarkable in curative effect, and clinical large-area application and popularization are facilitated.

Description

A kind of Chinese medicine preparation for the treatment of cyclomastopathy and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine preparation for the treatment of cyclomastopathy and preparation method thereof.

Background technology

Cyclomastopathy is that cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, and its pathogenic factor is mainly due to endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.

Traditional Chinese medicine thinks that cyclomastopathy is that Chinese medicine is referred to as " nodules of the breast " because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into caused by core.Modern medicine is then thought, its generation, develops and lapses to, and is because the hormonal circadian change in human female caused completely.When the estrogen level of ovarian secretion is too high, corpus luteum progestogen are very few, or both secretion is inharmonious, just can cause the breast ductal epithelial cells in breast and proliferation of fibrous tissue, i.e. ovarian cyst etc.When under the effect of body in some stressors (as work is too nervous, emotion is too exciting, advanced age is unmarried, not suckling in puerperal and suffer from some chronic disease etc.), the breast hyperplasia tissue just likely causing breast to restore can not get restoring or meromorphosis, in the course of time, just cyclomastopathy is formed.Show as the newborn leaf and nodular particles that thicken, the three large sings and symptomses such as distending pain of the breast and nipple galactorrhea.

Because the mechanism that occurs cyclomastopathy and the cause of disease there is no definite understanding, the treatment of current cyclomastopathy is symptomatic treatment substantially.As taken Western medicine under the guidance of doctor, pain severe patient can try out methyl testosterone or tamoxifen, starts oral within menstruation the last week, in order to avoid upset the fine balance between human hormone further.In addition, still have hormonotherapy, someone adopts androgen in treating primary disease, but this treatment likely aggravates between human hormone unbalance, unsuitable conventional application, only at serious symptom, when the normal work of impact and life, just considers to adopt.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine preparation for the treatment of cyclomastopathy, to cyclomastopathy, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine preparation for the treatment of cyclomastopathy, is made up of following component:

Semen Cassiae 10 ~ 20 parts, Flos Eriocauli 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, 10 ~ 20 parts, Radix Notoginseng, 10 ~ 20 parts, Nidus Vespae, 10 ~ 20 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Rhizoma Coptidis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Flos rosae multiflorae 10 ~ 20 parts, Squama Manis 1 ~ 15 part, Herba Artemisiae Anomalae 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 20 parts, Pumex 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Scorpio 1 ~ 15 part, 10 ~ 20 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 15 parts, Rhizoma Dioscoreae 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Caulis Piperis Kadsurae 10 ~ 20 parts, SEMEN COICIS 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Flos Caryophylli 10 ~ 20 parts, Pericarpium Citri tangerinae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Exocarpium Litchi 10 ~ 20 parts, Fructus Citri 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Fructus Lycii 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 15 parts, Colla Corii Asini.

As preferably, the present invention is made up of each component of following parts by weight:

Semen Cassiae 10 ~ 15 parts, Flos Eriocauli 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, 10 ~ 15 parts, Nidus Vespae, 10 ~ 15 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Rhizoma Coptidis 10 ~ 15 parts, Cortex Phellodendri 10 ~ 15 parts, Flos rosae multiflorae 10 ~ 20 parts, Squama Manis 1 ~ 12 part, Herba Artemisiae Anomalae 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 20 parts, Pumex 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Scorpio 1 ~ 12 part, 10 ~ 15 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 12 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Bulbus Lilii 10 ~ 20 parts, Caulis Piperis Kadsurae 10 ~ 15 parts, SEMEN COICIS 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 15 parts, Semen Abutili 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 15 parts, Flos Caryophylli 10 ~ 20 parts, Pericarpium Citri tangerinae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 20 parts, Exocarpium Litchi 10 ~ 15 parts, Fructus Citri 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Fructus Lycii 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 12 parts, Colla Corii Asini.

As preferably, the present invention is made up of each component of following parts by weight:

Semen Cassiae 10 ~ 20 parts, Flos Eriocauli 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, 10 ~ 20 parts, Radix Notoginseng, 10 ~ 20 parts, Nidus Vespae, 10 ~ 20 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Rhizoma Coptidis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Flos rosae multiflorae 10 ~ 15 parts, Squama Manis 1 ~ 12 part, Herba Artemisiae Anomalae 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 12 parts, Pumex 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Scorpio 1 ~ 12 part, 10 ~ 15 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 12 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Bulbus Lilii 10 ~ 15 parts, Caulis Piperis Kadsurae 10 ~ 15 parts, SEMEN COICIS 10 ~ 15 parts, Medulla Tetrapanacis 10 ~ 15 parts, Semen Abutili 10 ~ 15 parts, Rhizoma Zingiberis 10 ~ 15 parts, Flos Caryophylli 10 ~ 15 parts, Pericarpium Citri tangerinae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Exocarpium Litchi 10 ~ 15 parts, Fructus Citri 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Fructus Lycii 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 12 parts, Colla Corii Asini.

The dosage form of Chinese medicine preparation of the present invention is: product for oral administration: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup, and externally applied product is: patch, unguentum or spray.

As preferably, present invention also offers the preparation method of the Chinese medicine composition for the treatment of cyclomastopathy, its preparation comprises the following steps:

When described dosage form for oral administration is oral solutions, preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues water extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution sterilizing, adds dextrin, and then vacuum freezing seals and get final product.

In described step a, get crude drug to add in the ethanol of 3 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating is concentrated into extractum shape, stand for standby use, becomes component 1.

In described step b, 5 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 1 time, extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating is concentrated into extractum shape, stand for standby use, becomes component 2.

In described step c, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.

As preferably, present invention also offers the preparation method of the Chinese medicine composition composition powders for the treatment of cyclomastopathy, its preparation comprises the following steps:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding, obtains the second powder;

3rd step, is mixed in proportion remaining components, adds the water relative to mixture quality 10 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the 3rd powder;

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.

As preferably, present invention also offers the another kind of preparation method of the Chinese medicine composition composition powders for the treatment of cyclomastopathy, its preparation comprises the following steps:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding, obtains the second powder;

3rd step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.10 ~ 1.14, be ground into powder, obtain the 3rd powder,

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.

Theoretical foundation of the present invention:

Semen Cassiae: bitter in the mouth, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, reducing blood pressure and blood fat.

Flos Eriocauli: nature and flavor: Xin Gan is cool.1. supplement to the Herbal: " sweet in the mouth is flat." 2. " Japan hanako materia medica ": " is cool." return through: enter liver, stomach warp." Bencao Jingshu ": " enter the sufficient bright warp of yin, yang of fainting." function cures mainly: wind and heat eliminating, improving acuity of vision and removing nebula.Control corneal nebula, night blindness, headache, toothache, sore throat, epistaxis.1. " Kaibao Bencao ": " main treatment sore throat, tooth wind pain, and all skin ulcer scabies." 2. " detailed outline ": " controls wind syndrome of head pain. blindness nebula film, raw nebula after pox, hemostasis."

Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding.Gui Jing: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Radix Notoginseng: nature and flavor: sweet, flat.1. " detailed outline ": " sweet in the mouth." 2. " Hunan medicine will ": " is pungent, flat, nontoxic." function cures mainly: invigorate blood circulation, hemostasis, removing toxic substances.Control traumatic injury, epistaxis, hemoptysis, spit blood, acute mastitis, innominate toxic swelling, insect bite.1. " BAICAO mirror ": " control acute mastitis toxic swelling, incised wound is stopped blooding, membranous pharyngitis, bilateral tonsillitis, cough." 2. " Hunan medicine will ": " promoting the circulation of blood is stopped blooding, heat-clearing and toxic substances removing."

Nidus Vespae: there is detoxicating and killing parasites, effect of wind-expelling pain-stopping.Be usually used in sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot, toothache, rheumatic arthralgia.

Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.

Radix Sophorae Flavescentis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Function cures mainly: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation

Cortex Phellodendri: nature and flavor: bitter, cold.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Flos rosae multiflorae: nature and flavor: sweet is cool.1. " medical material compilation of data ": " sweet, flat." 2. " Nanning City's medicine will ": " is sweet, cool." 3. " Chinese herbal medicine is commonly used in Shanghai ": " is pained, cold." function cures mainly: clearing away summer-heat, stomach function regulating, hemostasis.Control summer-heat to spit blood, thirsty, dysentery, malaria, knife injury is hemorrhage.

Squama Manis: nature and flavor: salty, is slightly cold.Gui Jing: return liver, stomach warp.Function cures mainly: stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.

Herba Artemisiae Anomalae: nature and flavor: bitter, temperature.1. Tang Materia Medica: " bitter in the mouth, temperature." 2. " Japan hanako materia medica ": " is nontoxic." return through: enter the heart, spleen channel.1. " Thunder God concocts property of medicine solution ": " enter the heart, lung two warp." 2. " book on Chinese herbal medicine is newly organized ": " enters the heart, spleen, urinary bladder channel." 3. " book on Chinese herbal medicine is new again ": " enters liver, kidney two warp." function cures mainly: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.

Semen Strychni: nature and flavor: bitter, temperature; Very toxic.Gui Jing: return liver, spleen channel.Function cures mainly: removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain; Poliomyelitis sequela, rheumatoid arthritis.

Fructus Cnidii: nature and flavor: pungent, bitter, temperature; Slightly poisonous.Gui Jing: return kidney channel.Function cures mainly: warming the kidney to invigorate YANG, and dampness is dispeled the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.

The Rhizoma Pinelliae: nature and flavor: pungent, temperature; Poisonous.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.

Before hundred: nature and flavor: pungent, bitter, tepor.Gui Jing: return lung meridian.Function cures mainly: sending down the abnormal ascending QI, expectorant, cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.

Pumex: softening masses by salty flavor is hard, cold relaxing the bowels with lubricant drugs, color lean type is light, and enter lung antitussive, change old expectorant, the goiter that disappears tuberculosis, foam is formed.

Caulis Polygoni Multiflori: nature and flavor: sweet is flat.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; External treatment skin pruritus.

Scorpio: nature and flavor: pungent, flat; Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Rhizoma Gastrodiae: nature and flavor: sweet is flat.Gui Jing: return Liver Channel.Function cures mainly: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.

Radix Codonopsis: nature and flavor: sweet is flat.Gui Jing: return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Rhizoma Dioscoreae: nature and flavor: sweet, flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Bulbus Lilii: nature and flavor: sweet micro-hardship, flat.1. " herbal classic): " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. herbal for Relief of Famines: " sweet in the mouth is pungent, flat." 4. " Changsha medicine solution ": " sweet and slightly bitter taste, is slightly cold." return through: enter the heart, lung meridian.1. " Thunder God process of preparing Chinese medicine property of medicine solution " > Thunder God concocts property of medicine solution ": " enter cardiopulmonary, large and small intestinal four warp.It is lunar that " 2. " book on Chinese herbal medicine converge with speech ": " enters brothers, and brothers faint the moon, brothers' Yangming Channel." 3. " medicineization justice ": " enters lung, the heart, gallbladder three warp." function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells; Beriberi edema.

Caulis Piperis Kadsurae: wind-damp dispelling; The meridian dredging; Regulate the flow of vital energy; Pain relieving.Main anemofrigid-damp arthralgia; Arthrodynia of extremities; The contracture of muscle arteries and veins; Coldness and pain in the epigastrium; Edema.Control anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.

SEMEN COICIS: main arthralgia chiefly caused by damp pathogen, sharp the intestines and stomach, consumer edema, moist skin, whitening is mended wet, except speckle, cool property clearing away heat and removing summer.Kernel is not only excellent nutriment, and has diuresis and antitumaous effect.Be applicable to beriberi edema, the carcinoma initial stage.Its root is for driving ascarid medicine.It is cold, easy imapirment of the spleen and stomach, and must tremble with fear must using warming therapy.

Medulla Tetrapanacis: supplement to the Herbal: rice-paper plant, raw versant.Leaf is like Bi fiber crops, and have flesh in the heart, gently lovely in vain, woman worker gets with jewelry." elegant " cloud takes off also from southern, alive.Cloud medicinal herbs, the raw south of the River, main parasitosis, modern custom is name Medulla Tetrapanacis also.Medulla Tetrapanacis is promoting diuresis to clear away damp pathogen Chinese medicine, cures mainly: the puckery pain of hygropyrexia dark coloured urine, gonorrhea, edema oliguria, agalactia.

Semen Abutili: nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be nontoxic." 3. " property of medicine opinion ": " is sliding, flat." 4. " book on Chinese herbal medicine is new again ": " sweet-bitter flavor, cold nature is nontoxic." return through: enter intestine and small intestine, urinary bladder channel.1. " Thunder God concocts property of medicine solution ": " enter small intestinal, bladder two warp." 2. " must join book on Chinese herbal medicine ": " enters meridian of Foot-TAI YIN edema caused by disorder of QI." 3. " book on Chinese herbal medicine is looked for the truth ": " enters stomach, intestine and small intestine." 4. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." function cures mainly: diuretic, laxation, stimulating milk secretion.Control constipation and anuresis, gonorrhea, edema, women's galactozemia, breast swell and pain.

Rhizoma Zingiberis: acrid in the mouth, warm in nature.Enter stomach of foot Yang Ming, spleen of Foot-Taiyin, liver meridian, lung meridian.Dampness warming middle-JIAO, the strongly fragrant the turbid descending of row, tonification fire soil, diet of dissolving, warming the spleen and stomach and warm brothers, regulate yin-yang and determine vomiting, the inverse and flat cough of undershoot, proposes detrapping and on-slip is let out.Zhen Wu Tang, Decoction for strengthening the Spleen-Yang is added and subtracted: lower sharp person, goes Radix Paeoniae, adds Rhizoma Zingiberis.

Flos Caryophylli: nature and flavor: pungent, temperature.1. " Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." 2. " detailed outline ": " is pungent, heat." return through: enter stomach, spleen, kidney channel.1. Materia Medica of Decoction: " start with lunar, bright, the shaoyin channel of foot sun." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach, kidney four warp." function cures mainly: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.

Pericarpium Citri tangerinae: meridian distribution of property and flavor: acrid in the mouth and micro-hardship, temperature, enters spleen, lung meridian.Function cures mainly: in reasonable controlled atmosphere, drying dampness to eliminate phlegm effect, can be used for treating stagnation of QI in spleen and stomach, distension and fullness in the abdomen, and vomiting, or uncomfortable in chest caused by turbid damp obstructing in middle-JIAO, indigestion and loss of appetite, loose stool, but YIN fluid deficiency, person is cautious use of inside to have excess-heat.

Rhizoma Cyperi: nature and flavor: pungent, micro-hardship, micro-sweet, flat.Gui Jing: return liver, spleen, tri-jiao channel.Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Exocarpium Litchi: nature and flavor: bitter; Cool.Gui Jing: heart channel.Function cures mainly: dehumidifying dysentery relieving; Hemostasis.Main dysentery; Metrorrhagia; Eczema.

Fructus Citri: nature and flavor: pungent, bitter, sour, temperature.Gui Jing: return liver, spleen, lung meridian.Function cures mainly: liver-smoothing, qi-regulating, and alleviating distention in middle-JIAO reduces phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomiting eructation, abundant expectoration is coughed.

Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.1. Materia Medica of Decoction: " start with, meridian of Foot-JUE YIN." 2. " Thunder God concocts property of medicine solution ": " enters liver, large intestine two warp." 3. " book on Chinese herbal medicine is through separating ": " enters lung meridian, heart channel of Hand-Shaoyin, spleen meridian." function cures mainly: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.

Fructus Lycii: nature and flavor: sweet is flat.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Herba Menthae: nature and flavor: pungent is cool.Gui Jing: return lung, Liver Channel.Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.

Radix Ophiopogonis: sweet in the mouth, feeble QI is trembled with fear, and fall also, in sun, micro-the moon, nontoxic.Start with lunar, few cloudy.Volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin.The reducing the asthenic fever magical effect, separate the dryness of the lung and very test, surely coughing to cough has outstanding service greatly.Very can rely on for monarch, and can the making also for minister of mat.

Radix Trichosanthis: bitter in the mouth, cold in nature.Control lung abscess, evacuation of pus, disappear excessive thirst, only lung-heat, the traumatic injury that disappears blood stasis, the with the passing of time old expectorant yellow sputum in Qinghua, and the therapeutic method to keep the adverse QI flowing downwards is separated sore, controlled carbuncle pyogenic infections from tumour or sore, the band blood and cough-relieving is coughed.

Radix Rhapontici: nature and flavor: bitter, cold.Gui Jing: return stomach warp.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, and relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.

Colla Corii Asini: feeble QI temperature, sweet in the mouth is put down, and nontoxic, fall also, sun also.Can protect lung qi, nourishing the liver blood, tonify deficiency is thin, therefore arresting bleeding and miscarriage prevention, antitussive dysentery relieving, controls expectorant and controls flaccidity, all imitate.The disease person of only chronic cough chronic dysentery expectorant of a specified duration, and viscerasthenia hemorrhagia should use.

The preparation for the treatment of cyclomastopathy provided by the invention is pure Chinese medicinal preparation, has good curative effect to hyperplasia of mammary glands, has that the course for the treatment of is good, cost is low, easy to use, the feature that not easily recurs.The present invention according to theory of Chinese medical science formula, select medicine rationally, QI invigorating, enrich blood, blood circulation promoting and blood stasis dispelling, change hard eliminating stagnation, alleviating pain and detumescence, treating both the principal and secondary aspects of a disease.The present invention finds through clinical practice, and have unique curative effect to cyclomastopathy, effect of blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain played altogether by all medicines, reaches the object for the treatment of cyclomastopathy.It is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.

Detailed description of the invention

A lot of female patients thinks that cyclomastopathy is common disease, thus is negligent for the treatment of.In fact, only some slight patient just can spontaneous recovery after being nursed by appropriateness; Most humans need by just can thoroughly cure after treatment; Fraction patient is had again to develop into breast carcinoma.

Below in conjunction with specific embodiment, the present invention is further elaborated.

A, depend on pine torch 10 parts, Flos Eriocauli 10 parts, Herba Leonuri 10 parts, 10 parts, Radix Notoginseng, 10 parts, Nidus Vespae, 10 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 10 parts, Cortex Phellodendri 10 parts, Flos rosae multiflorae 10 parts, Squama Manis 1 part, Herba Artemisiae Anomalae 10 parts, Semen Strychni 10 parts, Fructus Cnidii 10 parts, the Rhizoma Pinelliae 10 parts, hundred first 10 parts, Pumex 10 parts, Caulis Polygoni Multiflori 10 parts, Scorpio 1 part, 10 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 parts, Rhizoma Dioscoreae 10 parts, Bulbus Lilii 10 parts, Caulis Piperis Kadsurae 10 parts, SEMEN COICIS 10 parts, Medulla Tetrapanacis 10 parts, Semen Abutili 10 parts, Rhizoma Zingiberis 10 parts, Flos Caryophylli 10 parts, Pericarpium Citri tangerinae 10 parts, Rhizoma Cyperi 10 parts, Exocarpium Litchi 10 parts, Fructus Citri 10 parts, Radix Rehmanniae Preparata 10 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts, Herba Menthae 10 parts, Radix Ophiopogonis 10 parts, Radix Trichosanthis 10 parts, Radix Rhapontici 10 parts, Colla Corii Asini 10 parts of crude drug add in the ethanol of 3 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 1,

5 times of water gagings put into by b, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 1 time, extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 2;

C, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.

Embodiment 2

The present embodiment comprises following weight composition: Semen Cassiae 10 parts, Flos Eriocauli 10 parts, Herba Leonuri 10 parts, 10 parts, Radix Notoginseng, 10 parts, Nidus Vespae, 10 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 10 parts, Cortex Phellodendri 10 parts, Flos rosae multiflorae 10 parts, Squama Manis 1 part, Herba Artemisiae Anomalae 10 parts, Semen Strychni 10 parts, Fructus Cnidii 10 parts, the Rhizoma Pinelliae 10 parts, hundred first 10 parts, Pumex 10 parts, Caulis Polygoni Multiflori 10 parts, Scorpio 1 part, 10 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 parts, Rhizoma Dioscoreae 10 parts, Bulbus Lilii 10 parts, Caulis Piperis Kadsurae 10 parts, SEMEN COICIS 10 parts, Medulla Tetrapanacis 10 parts, Semen Abutili 10 parts, Rhizoma Zingiberis 10 parts, Flos Caryophylli 10 parts, Pericarpium Citri tangerinae 10 parts, Rhizoma Cyperi 10 parts, Exocarpium Litchi 10 parts, Fructus Citri 10 parts, Radix Rehmanniae Preparata 10 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts, Herba Menthae 10 parts, Radix Ophiopogonis 10 parts, Radix Trichosanthis 10 parts, Radix Rhapontici 10 parts, 10 parts, Colla Corii Asini.

Its preparation comprises the following steps:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding, obtains the second powder;

3rd step, is mixed in proportion remaining components, adds the water relative to mixture quality 10 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the 3rd powder;

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.

Embodiment 3

The present embodiment comprises following weight composition: Semen Cassiae 11 parts, Flos Eriocauli 11 parts, Herba Leonuri 15 parts, 12 parts, Radix Notoginseng, 10 parts, Nidus Vespae, 12 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 parts, Radix Sophorae Flavescentis 10 parts, Rhizoma Coptidis 10 parts, Cortex Phellodendri 10 parts, Flos rosae multiflorae 11 parts, Squama Manis 1 part, Herba Artemisiae Anomalae 10 parts, Semen Strychni 10 parts, Fructus Cnidii 10 parts, the Rhizoma Pinelliae 10 parts, hundred first 10 parts, Pumex 11 parts, Caulis Polygoni Multiflori 10 parts, Scorpio 1 part, 10 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 parts, Rhizoma Dioscoreae 10 parts, Bulbus Lilii 10 parts, Caulis Piperis Kadsurae 10 parts, SEMEN COICIS 10 parts, Medulla Tetrapanacis 10 parts, Semen Abutili 10 parts, Rhizoma Zingiberis 15 parts, Flos Caryophylli 10 parts, Pericarpium Citri tangerinae 10 parts, Rhizoma Cyperi 10 parts, Exocarpium Litchi 10 parts, Fructus Citri 10 parts, Radix Rehmanniae Preparata 10 parts, 10 parts, Semen Persicae, Fructus Lycii 10 parts, Herba Menthae 10 parts, Radix Ophiopogonis 10 parts, Radix Trichosanthis 10 parts, Radix Rhapontici 10 parts, 10 parts, Colla Corii Asini.

Its preparation comprises the following steps:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding, obtains the second powder;

3rd step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.10 ~ 1.14, be ground into powder, obtain the 3rd powder,

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.

Toxicity test:

Laboratory animal

White mice is provided by Qingdao City's laboratory animal and animal experimental center.

Mice lavage administration acute toxicity testing

Get healthy mice 32, male and female half and half, within 24 hours, divide three groups, only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.

Rat oral gavage administration long term toxicity test

Toxicity test:

Healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.

Test rat body weight, diet, emotion, movable energy.Hemogram checking red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.Biochemical analysis: serum albumin is quantitative, cholesterol, blood sugar quantitative.Pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Experimental result represents: medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

Clinical trial

Pharmaceutical preparation of the present invention is to the Therapy study of hyperplasia of mammary gland model rat

Wistar rat 48, female unpregnancy, weight (250 ± 10) g, is divided into 4 groups at random, often organizes 12.Except Normal group, all the other are respectively organized rat and process as follows: every intramuscular injection estradiol benzoate 0.2ml/kg/d, intramuscular injection progesterone injection 0.4ml/kg/d after continuous 25d, altogether 5d, thus obtain cyclomastopathy rat model.Each group of rat gives tested material with dosage as follows:

Normal group: intramuscular injection 0.9% sodium chloride solution 1ml/kg/d, gavages 0.9% sodium chloride solution, 1 time/d on the 31st day, altogether 30d.

Model control group: gavage 0.9% sodium chloride solution after modeling, 1 time/d, 30d altogether.

Positive controls: gavage tamoxifen 20mg/kg/d after modeling, 1 time/d, 30d altogether.

Chinese drug-treated group: the oral liquid sample 7mlkg gavaging following Chinese medicine embodiment 1 after modeling ^-1d ^-1, 1 time/d, 30d altogether.

After above last administration, 8h precision vernier callipers measures the 3rd pair of papilla diameter; Separation of serum after getting eyeball blood in the 2nd day, adopts the value of serum measured by radioimmunoassay estradiol, progesterone, lactotropin.

Model group compares papilla diameter and obviously increases (P<0.01) with Normal group, modeling success is described.And compared with model group, the papilla diameter of positive controls, Chinese drug-treated group reduces (P<0.01), in serum, estradiol and lactotropin content all reduce (P<0.01, or P<0.05), in serum, progesterone content raises, illustrate that tamoxifen and treatment by Chinese herbs of the present invention all can effectively to the cyclomastopathy that estrogen antagonist causes, there was no significant difference (P>0.05, in table 1) between Chinese drug-treated group and positive controls.

Table l respectively organizes rat papilla diameter and estrogen level compares

Compare with model control group, * P < 0.05, * * P < 0.01.

Clinical data

Case selection: in 129 routine patients, in age 25-59 year, the course of disease is many at 1 month to 2 years, 35 years old mean age.

" Chinese medical disease Standardization of diagnosis and curative effect " that diagnostic criteria diagnosis basis State Administration of Traditional Chinese Medicine issues: symptom is periodicity or aperiodicity mastalgia, pain present is twinge, distending pain or has a dull ache, and often betides or add and overweight before menstruation or menstrual phase.Health check-up lump is often multiple, flat or beading nodules, and tuberosity is not of uniform size, and matter is soft, and border is clear, and with surrounding tissue without adhesion, or premenstrual lump increases, and reduces after row.All be diagnosed as cyclomastopathy through mammary gland color ultrasound or breast molybdenum target inspection or pathologic finding.

Clinical treatment: the oral liquid formulations taking the embodiment of the present invention 1, three times on the one one week is a course for the treatment of, according to the state of an illness, takes the circumstances into consideration administration.

Criterion of therapeutical effect

" the disease of tcm Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine is formulated.1. fully recover: distending pain of the breast and lump disappear, take the photograph sheet inspection in conjunction with breast molybdenum target and confirm the disappearance of cyclomastopathy sign.Within after drug withdrawal 3 months, do not recur.2. effective: distending pain of the breast disappears, and lump maximum gauge reduces more than 50%, breast molybdenum target is taken the photograph sheet inspection and is confirmed that cyclomastopathy tuberosity reduces or hypertrophy gland density alleviates and conforms to clinical.3. effective: distending pain of the breast alleviates, physical palpation mass reduction, but not as good as 50%, breast molybdenum target is taken the photograph sheet inspection and is confirmed that cyclomastopathy takes a turn for the better, and substantially conforms to palpation with clinical symptoms.4. invalid: distending pain of the breast is not improved compared with before treatment with lump, and breast molybdenum target takes the photograph sheet inspection confirmation.

Result: in 129 routine patients, 82 examples of fully recovering (63.6%), effective 39 examples (30.2%), invalid 8 examples (6.2%), total effective rate is 93.8%.

Model case:

(1), Jiang, female 30 years old, on May 20th, 2014 carrys out here first visit, and right breast has the lump of Semen Viciae fabae size on inspection, after taking a course for the treatment of of oral liquid of the present invention, further consultation, takes the photograph sheet inspection through hospital's x-ray, lump thoroughly disappears, and health recovers normal completely, recovery from illness.Pay a return visit after 1 year, healthy.

(2), grandson, female, 39 years old.On October 4th, 2015 carrys out here first visit, on inspection several enclosed mass that differs in size in bilateral breast.Both sides breast can touch multiple circle or oval lump of differing in size, and matter is tough, has tenderness, and push away movable, color of the leather is normal, and nipple is without discharge.Pale tongue, tongue is white, stringy and rolling pulse.Mammary gland color ultrasound, the inspection of breast molybdenum target, pathological examination are all diagnosed as bilateral breast cyclomastopathy disease.Take medicine of the present invention, after 2 courses for the treatment of, symptom is improved, and pain obviously alleviates, and continues to take 3 courses for the treatment of, and lump in breast and pain disappear completely, and recovery from illness is followed up a case by regular visits to after 1 year without recurrence.

(3), Liu so-and-so, female, 40 years old.Within 2015, December carrys out here first visit on 18th, bilateral breast hypertrophy is as Ovum Columba livia size lump on inspection, comparatively firmly can move, have tenderness sense, x-ray is taken the photograph sheet inspection and is suffered from bilateral breast hypertrophy disease, take medicine of the present invention, after 3 courses for the treatment of, take the photograph sheet inspection through hospital's x-ray, lump thoroughly disappears, health recovers normal completely, recovery from illness.Pay a return visit after 1 year, healthy.

The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (10)

1. treat a Chinese medicine preparation for cyclomastopathy, it is characterized in that: be made up of following component:

Semen Cassiae 10 ~ 20 parts, Flos Eriocauli 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, 10 ~ 20 parts, Radix Notoginseng, 10 ~ 20 parts, Nidus Vespae, 10 ~ 20 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Rhizoma Coptidis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Flos rosae multiflorae 10 ~ 20 parts, Squama Manis 1 ~ 15 part, Herba Artemisiae Anomalae 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 20 parts, Pumex 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Scorpio 1 ~ 15 part, 10 ~ 20 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 15 parts, Rhizoma Dioscoreae 10 ~ 20 parts, Bulbus Lilii 10 ~ 20 parts, Caulis Piperis Kadsurae 10 ~ 20 parts, SEMEN COICIS 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 20 parts, Semen Abutili 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Flos Caryophylli 10 ~ 20 parts, Pericarpium Citri tangerinae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Exocarpium Litchi 10 ~ 20 parts, Fructus Citri 10 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Fructus Lycii 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Radix Ophiopogonis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 15 parts, Colla Corii Asini.

2. a kind of Chinese medicine preparation for the treatment of cyclomastopathy according to claim 1, is characterized in that: be made up of each component of following parts by weight:

Semen Cassiae 10 ~ 15 parts, Flos Eriocauli 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, 10 ~ 15 parts, Radix Notoginseng, 10 ~ 15 parts, Nidus Vespae, 10 ~ 15 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Rhizoma Coptidis 10 ~ 15 parts, Cortex Phellodendri 10 ~ 15 parts, Flos rosae multiflorae 10 ~ 20 parts, Squama Manis 1 ~ 12 part, Herba Artemisiae Anomalae 10 ~ 20 parts, Semen Strychni 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 20 parts, Pumex 10 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Scorpio 1 ~ 12 part, 10 ~ 15 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 12 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Bulbus Lilii 10 ~ 20 parts, Caulis Piperis Kadsurae 10 ~ 15 parts, SEMEN COICIS 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 15 parts, Semen Abutili 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 15 parts, Flos Caryophylli 10 ~ 20 parts, Pericarpium Citri tangerinae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 20 parts, Exocarpium Litchi 10 ~ 15 parts, Fructus Citri 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Fructus Lycii 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 12 parts, Colla Corii Asini.

3. according to a kind of Chinese medicine preparation for the treatment of cyclomastopathy described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:

Semen Cassiae 10 ~ 20 parts, Flos Eriocauli 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, 10 ~ 20 parts, Radix Notoginseng, 10 ~ 20 parts, Nidus Vespae, 10 ~ 20 parts, Radix Glycyrrhizae, Fructus Forsythiae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Rhizoma Coptidis 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Flos rosae multiflorae 10 ~ 15 parts, Squama Manis 1 ~ 12 part, Herba Artemisiae Anomalae 10 ~ 15 parts, Semen Strychni 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, the Rhizoma Pinelliae 10 ~ 20 parts, before hundred 10 ~ 12 parts, Pumex 10 ~ 15 parts, Caulis Polygoni Multiflori 10 ~ 15 parts, Scorpio 1 ~ 12 part, 10 ~ 15 parts, Rhizoma Gastrodiae, Radix Codonopsis 10 ~ 12 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Bulbus Lilii 10 ~ 15 parts, Caulis Piperis Kadsurae 10 ~ 15 parts, SEMEN COICIS 10 ~ 15 parts, Medulla Tetrapanacis 10 ~ 15 parts, Semen Abutili 10 ~ 15 parts, Rhizoma Zingiberis 10 ~ 15 parts, Flos Caryophylli 10 ~ 15 parts, Pericarpium Citri tangerinae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Exocarpium Litchi 10 ~ 15 parts, Fructus Citri 10 ~ 15 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Fructus Lycii 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Radix Ophiopogonis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Radix Rhapontici 10 ~ 20 parts, 10 ~ 12 parts, Colla Corii Asini.

4. a kind of Chinese medicine preparation for the treatment of cyclomastopathy according to claims 1 to 3, it is characterized in that: product for oral administration: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup, externally applied product is: patch, unguentum or spray.

5. a kind of Chinese medicine preparation for the treatment of cyclomastopathy according to Claims 1-4, is characterized in that: when described dosage form for oral administration is oral solutions, preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues water extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution sterilizing, adds dextrin, and then vacuum freezing seals and get final product.

6. a kind of preparation method for the treatment of the Chinese medicine preparation of cyclomastopathy according to claim 5, is characterized in that: in described step a, gets crude drug and adds in the ethanol of 3 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 1.

7. a kind of preparation method for the treatment of the Chinese medicine preparation of cyclomastopathy according to claim 5, it is characterized in that: in described step b, 5 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 1 time, and extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, heating be concentrated into extractum shape, stand for standby use, becomes component 2.

8. a kind of preparation method for the treatment of the Chinese medicine preparation of cyclomastopathy according to claim 5, it is characterized in that: in described step c, above-mentioned two kinds of component extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, add dextrin, then vacuum canning sealing and get final product, directly drink during use.

9. a kind of Chinese medicine preparation for the treatment of cyclomastopathy according to Claims 1-4, is characterized in that: when described dosage form for oral administration is powder, preparation method comprises:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding, obtains the second powder;

3rd step, is mixed in proportion remaining components, adds the water relative to mixture quality 10 times, boil 1 hour, filter, obtain the first filtrate, filtering residue adds the water relative to 5 times, mixture again, again boils 3 hours, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated, except anhydrating, dry, pulverize, obtain the 3rd powder;

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.

10. a kind of Chinese medicine preparation for the treatment of cyclomastopathy according to Claims 1-4, is characterized in that: when described dosage form for oral administration is powder, preparation method comprises:

The first step, by Semen Cassiae, Flos Eriocauli, Herba Leonuri, Radix Notoginseng, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Cortex Phellodendri, Flos rosae multiflorae, Herba Artemisiae Anomalae, Semen Strychni, the Rhizoma Pinelliae, before hundred, Caulis Polygoni Multiflori, Rhizoma Gastrodiae, Rhizoma Dioscoreae, Bulbus Lilii, Caulis Piperis Kadsurae, Medulla Tetrapanacis, Semen Abutili, Rhizoma Zingiberis, Pericarpium Citri tangerinae, Exocarpium Litchi, Fructus Citri, Semen Persicae, Radix Trichosanthis and Radix Rhapontici are ground into powder respectively, be mixed in proportion, load in percolator, adding relative to the determining alcohol of mixture quality 7 times is the ethanol of 90%, soak 12 hours at ambient temperature, open the valve of percolator, alcoholic solution slowly oozes, the speed of oozing is 1ml per minute, collect drip, till ethanol drop to be oozed is colourless, concentrated, removing alcoholic solution, dry, pulverize, obtain the first powder,

Second step, by Pumex and Colla Corii Asini grinding grinding, obtains the second powder;

3rd step, remaining components is mixed in proportion, add 95% ethanol relative to mixture quality 3 times, boil 0.5 hour, filter, obtain the first filtrate, filtering residue adds relative to 2 times, mixture 95% again, again boil 0.5 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste also drying of 1.10 ~ 1.14, be ground into powder, obtain the 3rd powder,

4th step, mixes the first powder, the second powder and the 3rd powder, adds corresponding adjuvant, obtains Chinese powder medicine.