CN105435200A - Pharmaceutical composition for preventing and treating fowl plague of white pheasants and preparation method thereof - Google Patents
Pharmaceutical composition for preventing and treating fowl plague of white pheasants and preparation method thereof Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a pharmaceutical composition for preventing and treating fowl plague of white pheasants. The total weight of the pharmaceutical composition is 100g, and the pharmaceutical composition is prepared from the following raw materials measured by weight: 3 to 6 g of folium artemisiae argyi, 0.5 to 3.0 g of ficus microcarpa, 0.25 to 0.35 g of eight-leaved schefflera leaf, 0.2 to 0.3 g of lily, 0.5 to 0.6 g of radix isatidis, 0.2 to 0.4 g of radix glehniae, 0.5 to 0.6 g of peach juvenile branchlet, 0.2 to 0.4 g of atractylodes lancea, 0.25 to 0.35 g of radix liriopes, 0.2 to 0.3 g of radix aconiti kusnezoffii, 0.25 to 0.35 g of radix bupleuri, 0.25 to 0.35 g of probiotics powder, 0.2 to 0.3 g of rhizoma zingiberis, 0.5 to 3.0 g of glycyrrhiza, 0.25 to 0.35 g of radix ilicis asprellae, 0.2 to 0.3 g of rhododendron pulchrum, 0.5 to 0.6 g of radix puerariae, 0.25 to 0.35 g of rhiaoma iridis tectori, 0.5 to 0.6 g of rhizoma cibotii, 0.5 to 0.6 g of garlic extract and the balance of water. The pharmaceutical composition disclosed by the invention has a good effect of preventing and treating fowl plague of the white pheasants, can be easily promoted and applied and has a larger market prospect.
Description
Technical field
the present invention relates to a kind of white Gallus jabouillei medicament composing prescription, particularly relating to a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague and preparation method thereof.
Background technology
white Gallus jabouillei, also known as white Yushan Mountain chicken, white pheasant, belonging to Aves, Phasianidae, is the rare bird that the world has long enjoyed a good reputation.Be distributed in the Himalayas and western part of China, be difficult to the area procreation on close, many mountains people.The white Gallus jabouillei raised all over the world is formed through the raising domestication in more than 60 years, selection-breeding by mountain wild white Gallus jabouillei.Supertition in ancient times is with white Phasiana for auspicious sign, and " during all Chengwangs, more white Phasiana offered by skirt." " king's moral stream four is shown, then white Phasiana is shown in." pheasant mostly is red copper or bottle green, white pheasant is very rare.
the existing veterinary medicine prescription poor effect for white Gallus jabouillei fowl plague prevention, this problems demand solves.
Summary of the invention
for the deficiencies in the prior art, according to the principle of integration of edible and medicinal herbs, object of the present invention is intended to: provide a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague.
for achieving the above object, the present invention adopts following technical scheme: a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague, and measure by weight, total amount is 100 grams, it is characterized in that, comprising:
folium Artemisiae Argyi 3 ~ 6 grams; Ficus microcarpa Linn. f palpus 0.5 ~ 3.0 gram;
folium schefflerae octophyllae 0.25 ~ 0.35 gram; Bulbus Lilii 0.2 ~ 0.3 gram;
radix Isatidis 0.5 ~ 0.6 gram; Radix Glehniae 0.2 ~ 0.4 gram;
ramulus Persicae 0.5 ~ 0.6 gram; Rhizoma Atractylodis 0.2 ~ 0.4 gram;
radix Liriopes 0.25 ~ 0.35 gram; Radix Aconiti Kusnezoffii 0.2 ~ 0.3 gram;
radix Bupleuri 0.25 ~ 0.35 gram; 0.25 ~ 0.35 gram, probiotic bacteria powder;
rhizoma Zingiberis 0.2 ~ 0.3 gram; 0.5 ~ 3.0 gram, Radix Glycyrrhizae;
radix Ilicis Asprellae 0.25 ~ 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.2 ~ 0.3 gram;
radix Puerariae 0.5 ~ 0.6 gram; Rhizoma Belamcandae 0.25 ~ 0.35 gram;
rhizoma Cibotii 0.5 ~ 0.6 gram; Bulbus Allii extract 0.5 ~ 0.6 gram;
surplus is water.
preferably, measure by weight, total amount is 100 grams, comprising:
folium Artemisiae Argyi 4 grams; Ficus microcarpa Linn. f palpus 2.5 grams;
folium schefflerae octophyllae 0.25 gram; Bulbus Lilii 0.2 gram;
radix Isatidis 0.5 gram; Radix Glehniae 0.2 gram;
ramulus Persicae 0.5 gram; Rhizoma Atractylodis 0.2 gram;
radix Liriopes 0.25 gram; Radix Aconiti Kusnezoffii 0.2 gram;
radix Bupleuri 0.25 gram; 0.25 gram, probiotic bacteria powder;
rhizoma Zingiberis 0.2 gram; 0.5 gram, Radix Glycyrrhizae;
radix Ilicis Asprellae 0.25 gram; Folium et Cacumen Rhododendri Mariae 0.2 gram;
radix Puerariae 0.5 gram; Rhizoma Belamcandae 0.25 gram;
rhizoma Cibotii 0.5 gram; Bulbus Allii extract 0.5 gram;
surplus is water.
preferably, measure by weight, total amount is 100 grams, comprising:
folium Artemisiae Argyi 4.5 grams; Ficus microcarpa Linn. f palpus 3.0 grams;
folium schefflerae octophyllae 0.35 gram; Bulbus Lilii 0.3 gram;
radix Isatidis 0.6 gram; Radix Glehniae 0.4 gram;
ramulus Persicae 0.6 gram; Rhizoma Atractylodis 0.4 gram;
radix Liriopes 0.35 gram; Radix Aconiti Kusnezoffii 0.3 gram;
radix Bupleuri 0.35 gram; 0.35 gram, probiotic bacteria powder;
rhizoma Zingiberis 0.3 gram; 3.0 grams, Radix Glycyrrhizae;
radix Ilicis Asprellae 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.3 gram;
radix Puerariae 0.6 gram; Rhizoma Belamcandae 0.35 gram;
rhizoma Cibotii 0.6 gram; Bulbus Allii extract 0.6 gram;
surplus is water.
the present invention also provides a kind of preparation method, comprises the steps:
steps A: carry out selection according to the formula as described in any one of claims 1 to 3;
step B: raw material pulverizer steps A obtained is crushed to 50 order to 100 orders, makes powder;
step C: the powder obtained by step B adds in agitator, and injects mixture of ice and water in agitator, carries out stirring 3.5 hours with the rotating speed of 45 rpms;
step D: the intermediate products obtained by step C inject in reactor, pass into the high steam of 121 DEG C, 10 minutes in reactor;
step e: filter cleaner, obtains mother solution.
preferably, after step e, also have step F 1, in order to configure 5 times of diluents, measure by volume,
step F 1: get 1 part, mother solution, drinking water 4 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
preferably, after step e, also have step F 2, in order to configure 10 times of diluents, measure by volume,
step F 2: get 1 part, mother solution, drinking water 9 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
preferably, described water is distilled water.
preferably, also G in steps after described step e,
step G: mother solution is flow through the glass tubing being contained with active carbon, removing pigment, leaves clear liquid for subsequent use.
compared to existing technology, the beneficial effect of a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague of the present invention is:
1, the present invention is good for the preventive effect of white Gallus jabouillei fowl plague, can effectively contain spreading of white Gallus jabouillei fowl plague, of far-reaching significance for control and prevention of disease.By the prescription of science, particularly orthogonal test, drawn above-mentioned formula, proportioning, the formula of optimization is very efficient for the prevention of fowl plague, improves the immunity of white Gallus jabouillei.Safety has no side effect, and zest is little, and safety is high, does not have drug residue, and pure natural is nuisanceless, meets the demand of livestock-raising.By giving white Gallus jabouillei feeding preparation of the present invention, can prevent spreading of fowl plague in white Gallus jabouillei population, preventive effect is good.
, in feeding process, 10 times of diluents can be used to be used as white Gallus jabouillei feed additive, effectively can to prevent fowl plague, can reduce in the fowl plague outbreak period and improve the dilution ratio of medicine, and then obtain better preventive effect.
, through statistical proof, formula of the present invention has significant effect for the prevention of white Gallus jabouillei fowl plague.
, adopt compositions of the present invention to carry out preventing white Gallus jabouillei fowl plague, white Gallus jabouillei can be improved and infect the probability of fowl plague, and then improve the economic benefit of plant on the whole.
Detailed description of the invention
the specific embodiment of the present invention is as follows:
embodiment one
the invention provides a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague, measure by weight, total amount is 100 grams, comprising: Folium Artemisiae Argyi 3 ~ 6 grams; Ficus microcarpa Linn. f palpus 0.5 ~ 3.0 gram; Folium schefflerae octophyllae 0.25 ~ 0.35 gram; Bulbus Lilii 0.2 ~ 0.3 gram; Radix Isatidis 0.5 ~ 0.6 gram; Radix Glehniae 0.2 ~ 0.4 gram; Ramulus Persicae 0.5 ~ 0.6 gram; Rhizoma Atractylodis 0.2 ~ 0.4 gram; Radix Liriopes 0.25 ~ 0.35 gram; Radix Aconiti Kusnezoffii 0.2 ~ 0.3 gram; Radix Bupleuri 0.25 ~ 0.35 gram; 0.25 ~ 0.35 gram, probiotic bacteria powder; Rhizoma Zingiberis 0.2 ~ 0.3 gram; 0.5 ~ 3.0 gram, Radix Glycyrrhizae; Radix Ilicis Asprellae 0.25 ~ 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.2 ~ 0.3 gram; Radix Puerariae 0.5 ~ 0.6 gram; Rhizoma Belamcandae 0.25 ~ 0.35 gram; Rhizoma Cibotii 0.5 ~ 0.6 gram; Bulbus Allii extract 0.5 ~ 0.6 gram; Surplus is water.
when selection, counter balance or electronic balance can be adopted to weigh.Specifically, water can adopt tap water or adopt distilled water.
embodiment two
the invention provides a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague, measure by weight, total amount is 100 grams, comprising: Folium Artemisiae Argyi 4 grams; Ficus microcarpa Linn. f palpus 2.5 grams; Folium schefflerae octophyllae 0.25 gram; Bulbus Lilii 0.2 gram; Radix Isatidis 0.5 gram; Radix Glehniae 0.2 gram; Ramulus Persicae 0.5 gram; Rhizoma Atractylodis 0.2 gram; Radix Liriopes 0.25 gram; Radix Aconiti Kusnezoffii 0.2 gram; Radix Bupleuri 0.25 gram; 0.25 gram, probiotic bacteria powder; Rhizoma Zingiberis 0.2 gram; 0.5 gram, Radix Glycyrrhizae; Radix Ilicis Asprellae 0.25 gram; Folium et Cacumen Rhododendri Mariae 0.2 gram; Radix Puerariae 0.5 gram; Rhizoma Belamcandae 0.25 gram; Rhizoma Cibotii 0.5 gram; Bulbus Allii extract 0.5 gram; Surplus is water.
when selection, counter balance or electronic balance can be adopted to weigh.Specifically, water can adopt tap water or adopt distilled water.
embodiment three
the invention provides a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague, measure by weight, total amount is 100 grams, comprising: Folium Artemisiae Argyi 4.5 grams; Ficus microcarpa Linn. f palpus 3.0 grams; Folium schefflerae octophyllae 0.35 gram; Bulbus Lilii 0.3 gram; Radix Isatidis 0.6 gram; Radix Glehniae 0.4 gram; Ramulus Persicae 0.6 gram; Rhizoma Atractylodis 0.4 gram; Radix Liriopes 0.35 gram; Radix Aconiti Kusnezoffii 0.3 gram; Radix Bupleuri 0.35 gram; 0.35 gram, probiotic bacteria powder; Rhizoma Zingiberis 0.3 gram; 3.0 grams, Radix Glycyrrhizae; Radix Ilicis Asprellae 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.3 gram; Radix Puerariae 0.6 gram; Rhizoma Belamcandae 0.35 gram; Rhizoma Cibotii 0.6 gram; Bulbus Allii extract 0.6 gram; Surplus is water.
when selection, counter balance or electronic balance can be adopted to weigh.Specifically, water can adopt tap water or adopt distilled water.
embodiment four
the invention provides a kind of a kind of preparation method for the preparation of the compositions described in embodiment one to three, comprise the steps: steps A: carry out selection according to the formula as described in any one of claims 1 to 3; Step B: raw material pulverizer steps A obtained is crushed to 50 order to 100 orders, makes powder; Step C: the powder obtained by step B adds in agitator, and injects mixture of ice and water in agitator, carries out stirring 3.5 hours with the rotating speed of 45 rpms; Step D: the intermediate products obtained by step C inject in reactor, pass into the high steam of 121 DEG C, 10 minutes in reactor; Step e: filter cleaner, obtains mother solution.Here need to ensure that the powder that step B obtains adds that mixture of ice and water should meet the proportioning of the present embodiment.
embodiment five
on the basis of embodiment four, after step e, also have step F 1, in order to configure 5 times of diluents, measure by volume, step F 1: get 1 part, mother solution, drinking water 4 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
embodiment six
after step e, also have step F 2, in order to configure 10 times of diluents, measure by volume, step F 2: get 1 part, mother solution, drinking water 9 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
embodiment seven
also G, step G in steps after described step e: mother solution is flow through the glass tubing being contained with active carbon, removing pigment, leaves clear liquid for subsequent use.
test method:
randomly draw white Gallus jabouillei 120 in plant, wherein, 30 as a control group, 30 as mother solution test group, 5 times of diluent test group, 10 times of diluent test group.The sample number of each group is all 30, the requirement of coincidence statistics.
to common anti-fowl plague medicine 1 weight portion of matched group feeding every day, to mother solution test group feeding every day mother solution 1 weight portion, to 5 times of diluent test group feedings every day, 5 times of diluent 1 weight portions, 10 times of diluent test group feedings every day, 10 times of diluent 1 weight portions.Test 7 days by a definite date.Attention: 1 weight portion here with reference to the input standard of common prevention fowl plague medicine, as 1 gram.
Within 1st day, suffer from the quantity of fowl plague | Within 2nd day, suffer from the quantity of fowl plague | Within 4th day, suffer from the quantity of fowl plague | Within 7th day, suffer from the quantity of fowl plague | |
Matched group | 6 | 10 | 15 | 20 |
Mother solution test group | 1 | 1 | 3 | 3 |
5 times of diluent test group | 2 | 3 | 4 | 5 |
10 times of diluent test group | 3 | 4 | 5 | 7 |
statistical analysis is carried out to above-mentioned result of the test and draws the following conclusion with statistical significance:
1, matched group and mother solution test group are carried out t inspection, obtain P=0.018005<0.05, that is, mother solution test group and matched group have the probability of more than 95% to have the difference of significance, and namely mother solution is significantly better than common drug for the preventive effect of fowl plague.
, matched group and 5 times of diluent test group are carried out t inspection, obtain P=0.026315<0.05, that is, 5 times of diluent test group and matched group have the probability of more than 95% to have the difference of significance, and namely 5 times of diluents are significantly better than common drug for the preventive effect of fowl plague.
, matched group and 10 times of diluent test group are carried out t inspection, obtain P=0.036867<0.05, namely, 10 times of diluent test group and matched group have the probability of more than 95% to have the difference of significance, and namely 10 times of diluents are significantly better than common drug for the preventive effect of fowl plague.
in sum, in feeding process, 10 times of diluents can be used to be used as white Gallus jabouillei feed additive, effectively can to prevent fowl plague, the dilution ratio improving medicine can be reduced in the fowl plague outbreak period, and then obtain better preventive effect.The concentrated solution of mother solution of the present invention also has preventive effect.
it is to be noted: adopt mother solution prepared by formula of the present invention, can dilute between 10 times at 1 times, user can dilute according to practical situation.Dilute the effect that more than 10 times then do not have significant prevention fowl plague.Also it is pointed out that the increase along with extension rate, the effect of prevention fowl plague can be deteriorated.
compared to existing technology, the beneficial effect of a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague of the present invention is: the present invention is good for the preventive effect of white Gallus jabouillei fowl plague, can effectively contain spreading of white Gallus jabouillei fowl plague, of far-reaching significance for control and prevention of disease.By the prescription of science, particularly orthogonal test, drawn above-mentioned formula, proportioning, the formula of optimization is very efficient for the prevention of fowl plague, improves the immunity of white Gallus jabouillei.Safety has no side effect, and zest is little, and safety is high, does not have drug residue, and pure natural is nuisanceless, meets the demand of livestock-raising.By giving white Gallus jabouillei feeding preparation of the present invention, can prevent spreading of fowl plague in white Gallus jabouillei population, preventive effect is good.
to one skilled in the art, according to technical scheme described above and design, other various corresponding change and deformation can be made, and all these change and deformation all should belong within the protection domain of the claims in the present invention.
Claims (8)
1. for preventing and treating a pharmaceutical composition for white Gallus jabouillei fowl plague, measure by weight, total amount is 100 grams, it is characterized in that, comprising:
Folium Artemisiae Argyi 3 ~ 6 grams; Ficus microcarpa Linn. f palpus 0.5 ~ 3.0 gram;
Folium schefflerae octophyllae 0.25 ~ 0.35 gram; Bulbus Lilii 0.2 ~ 0.3 gram;
Radix Isatidis 0.5 ~ 0.6 gram; Radix Glehniae 0.2 ~ 0.4 gram;
Ramulus Persicae 0.5 ~ 0.6 gram; Rhizoma Atractylodis 0.2 ~ 0.4 gram;
Radix Liriopes 0.25 ~ 0.35 gram; Radix Aconiti Kusnezoffii 0.2 ~ 0.3 gram;
Radix Bupleuri 0.25 ~ 0.35 gram; 0.25 ~ 0.35 gram, probiotic bacteria powder;
Rhizoma Zingiberis 0.2 ~ 0.3 gram; 0.5 ~ 3.0 gram, Radix Glycyrrhizae;
Radix Ilicis Asprellae 0.25 ~ 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.2 ~ 0.3 gram;
Radix Puerariae 0.5 ~ 0.6 gram; Rhizoma Belamcandae 0.25 ~ 0.35 gram;
Rhizoma Cibotii 0.5 ~ 0.6 gram; Bulbus Allii extract 0.5 ~ 0.6 gram;
Surplus is water.
2. a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague according to claim 1, it is characterized in that, measure by weight, total amount is 100 grams, comprising:
Folium Artemisiae Argyi 4 grams; Ficus microcarpa Linn. f palpus 2.5 grams;
Folium schefflerae octophyllae 0.25 gram; Bulbus Lilii 0.2 gram;
Radix Isatidis 0.5 gram; Radix Glehniae 0.2 gram;
Ramulus Persicae 0.5 gram; Rhizoma Atractylodis 0.2 gram;
Radix Liriopes 0.25 gram; Radix Aconiti Kusnezoffii 0.2 gram;
Radix Bupleuri 0.25 gram; 0.25 gram, probiotic bacteria powder;
Rhizoma Zingiberis 0.2 gram; 0.5 gram, Radix Glycyrrhizae;
Radix Ilicis Asprellae 0.25 gram; Folium et Cacumen Rhododendri Mariae 0.2 gram;
Radix Puerariae 0.5 gram; Rhizoma Belamcandae 0.25 gram;
Rhizoma Cibotii 0.5 gram; Bulbus Allii extract 0.5 gram;
Surplus is water.
3. a kind of pharmaceutical composition for preventing and treating white Gallus jabouillei fowl plague according to claim 1, it is characterized in that, measure by weight, total amount is 100 grams, comprising:
Folium Artemisiae Argyi 4.5 grams; Ficus microcarpa Linn. f palpus 3.0 grams;
Folium schefflerae octophyllae 0.35 gram; Bulbus Lilii 0.3 gram;
Radix Isatidis 0.6 gram; Radix Glehniae 0.4 gram;
Ramulus Persicae 0.6 gram; Rhizoma Atractylodis 0.4 gram;
Radix Liriopes 0.35 gram; Radix Aconiti Kusnezoffii 0.3 gram;
Radix Bupleuri 0.35 gram; 0.35 gram, probiotic bacteria powder;
Rhizoma Zingiberis 0.3 gram; 3.0 grams, Radix Glycyrrhizae;
Radix Ilicis Asprellae 0.35 gram; Folium et Cacumen Rhododendri Mariae 0.3 gram;
Radix Puerariae 0.6 gram; Rhizoma Belamcandae 0.35 gram;
Rhizoma Cibotii 0.6 gram; Bulbus Allii extract 0.6 gram;
Surplus is water.
4. a preparation method, is characterized in that, comprises the steps:
Steps A: carry out selection according to the formula as described in any one of claims 1 to 3;
Step B: raw material pulverizer steps A obtained is crushed to 50 order to 100 orders, makes powder;
Step C: the powder obtained by step B adds in agitator, and injects mixture of ice and water in agitator, carries out stirring 3.5 hours with the rotating speed of 45 rpms;
Step D: the intermediate products obtained by step C inject in reactor, pass into the high steam of 121 DEG C, 10 minutes in reactor;
Step e: filter cleaner, obtains mother solution.
5. preparation method according to claim 4, is characterized in that, also has step F 1, in order to configure 5 times of diluents, measure by volume after step e,
Step F 1: get 1 part, mother solution, drinking water 4 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
6. preparation method according to claim 4, is characterized in that, also has step F 2, in order to configure 10 times of diluents, measure by volume after step e,
Step F 2: get 1 part, mother solution, drinking water 9 parts that step e obtains, stirring and evenly mixing in ceramic bucket.
7. preparation method according to claim 4, is characterized in that, described water is distilled water.
8. preparation method according to claim 4, is characterized in that, also G in steps after described step e,
Step G: mother solution is flow through the glass tubing being contained with active carbon, removing pigment, leaves clear liquid for subsequent use.
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CN105561262A (en) * | 2016-01-05 | 2016-05-11 | 陈小媚 | Formula for preventing chicken plague of Ross 308 broiler and preparation method thereof |
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CN102451459A (en) * | 2010-10-28 | 2012-05-16 | 陈呈礼 | Chinese medicine for treating fowl plague |
CN103550752A (en) * | 2013-11-19 | 2014-02-05 | 青岛农业大学 | Traditional Chinese medicine composition for treating fowl plague |
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CN102379920A (en) * | 2010-09-06 | 2012-03-21 | 北京大北农动物保健科技有限责任公司 | Veterinary antiviral and antifebrile drug composition |
CN102451459A (en) * | 2010-10-28 | 2012-05-16 | 陈呈礼 | Chinese medicine for treating fowl plague |
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