CN105435133A - Method for preparing traditional Chinese medicine preparation for treating bedsore - Google Patents

Method for preparing traditional Chinese medicine preparation for treating bedsore Download PDF

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CN105435133A
CN105435133A CN201610042694.4A CN201610042694A CN105435133A CN 105435133 A CN105435133 A CN 105435133A CN 201610042694 A CN201610042694 A CN 201610042694A CN 105435133 A CN105435133 A CN 105435133A
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chinese medicine
parts
traditional chinese
radix angelicae
preparation
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刘学键
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Qingdao Huazhicao Medical Technology Co Ltd
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Qingdao Huazhicao Medical Technology Co Ltd
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Abstract

The invention discloses a method for preparing a traditional Chinese medicine preparation for treating bedsore and belongs to the technical field of traditional Chinese medicine. The preparation method includes the steps that lumbricus, white sugar and borneol are made into fine powder, and olibanum and myrrh are prepared into fine powder; radix sngelica sinensis, roots of rehmannia, oldenlandia diffusa, rhizoma coptidis from Sichuan of China, turmeric, daemonorops draco, Chinese gall and radix angelicae are extracted to obtain a concentrated solution; the fine powder and the concentrated solution are mixed, a proper auxiliary material is added, and a traditional Chinese medicine finished product preparation which is clinically needed is obtained through a traditional Chinese medicine preparation technology which is currently used in the modern time. The traditional Chinese medicine preparation prepared through the method has the technical advantages of being quick in curative effect , good in curative effect, not prone to relapse and the like on the aspect of treatment of bedsore; the traditional Chinese medicine preparation is stable in medicinal effect, low in manufacturing cost and huge in social benefits.

Description

A kind of method preparing the Chinese medicine preparation for the treatment of decubital ulcer
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of method preparing the Chinese medicine preparation for the treatment of decubital ulcer.
Background technology
Decubital ulcer, also known as pressure ulcer, is due to the long-term pressurized of local organization, and continuous ischemia, anoxia, malnutrition and cause tissue fester's necrosis occur.Pressure ulcer is the problem of a universality in rehabilitation, nursing.According to related documents, 60,000 people are about had to die from pressure ulcer concomitant symptoms every year.Doctor trained in Western medicine thinks that the pathogenic factor of decubital ulcer is:
1, pressure factor
(1) pressure at right angle causes the topmost reason of pressure ulcer to be that local organization suffers persistence pressure at right angle, especially at health bone tuberosity protrusion place.If long-term bed or wheelchair, that clamping plate inner liner is placed is improper, in Gypsum Fibrosum out-of-flatness or have slag to consider to be worth doing, local bears the compressing exceeding normal terminal vessels for a long time, (pressure that the blood vessel generally speaking under skin layer can bear is about about 32mmHg all can to cause pressure ulcer, if exceed above pressure, local vascular just may distortion, distortion and have influence on passing through of blood flow, then have the phenomenon of ischemia).
(2) frictional force acts on skin, easily the horny layer of infringement skin.When patient in bed movable or wheelchair time, skin can be subject to the retrograde resistance friction on sheet and wheelchair cushion surface, as skin be scratched after be subject to the dipping of antiperspirant, urine, stool etc. time, easily there is pressure ulcer.
(3) the so-called shearing of shearing is that an active force imposes on after on object and causes the parallel reciprocal planar slide of generation one, is to be added with pressure at right angle by frictional force to form.It and position are in close relations, such as flat sleeping when raising the head of a bed health glide, there is parallel frictional force in skin and bed, adds the gravity of skin vertical direction, thus cause the generation of shearing, causes local skin disturbance of blood circulation and pressure ulcer occurs.
2, nutriture
Nutrition of whole body lacks, amyotrophy, and pressurized place lacks protection, as long-term fever and cachexia etc.
Nutrition of whole body obstacle; nutrition intake is not enough; there is protein synthesis minimizing, negative nitrogen balance, subcutaneous fat minimizing, amyotrophy; once pressurized; bone knuckle place skin will bear ambient pressure and bone knuckle place to the extruding force of skin; pressurized place lacks the protection of muscle and fatty tissue, causes disturbance of blood circulation to occur pressure ulcer.
3, skin resistance reduces
Skin often stimulates (as plaster bandage and clamping plate improper use, gatism, sheet gauffer injustice, bed have chip etc.) by the physical property such as humidity, friction, and skin resistance is reduced.
The therapies such as doctor trained in Western medicine many employings antibiotic, weak effect, easy recurrent exerbation, causes serious consequence.
The traditional Chinese medical science thinks that decubital ulcer is many because of deficient qi and blood, and caused by qi depression to blood stasis, prolonged illness is liied in bed, pressurized position stagnation of QI-blood, and blood vessels are obstructed, meridians obstruct, and deficiency of both QI and blood, invades in malicious heresy, and the mistake of muscle muscles and bones supports rotten one-tenth skin ulcer of then bursting, and touching difficulty more.Control with dredging the meridian, blood circulation promoting and blood stasis dispelling as principle.
1, deficient qi and blood
Syndrome: this type is equivalent to the initial stage, palor, greyish white or green lake, boundary is clear, and center color is comparatively dark, and asthenia universalis is unable, poor appetite, pale tongue, and tongue is white, deep-thready pulse.
(1) dialectical: primary disease is more common in the initial stage, skin lesion is pale, red red, and burst bad, deep-thready pulse is dialectical main points.
(2) pathogenesis: deficient qi and blood, venation is obstructed, and failure of skin and muscle to be nourished then skin lesion is pale or red red, and color is dark, diabrosis.Deep-thready pulse is resembling of deficient qi and blood.
Method for the treatment of: benefiting vital QI and blood, dredging collateral skin moistening.
2, qi depression to blood stasis
Syndrome: this type is equivalent to the later stage; Vesicle is played on skin lesion surface, ulcer after broken, and muscle, bone surface form necrosis, and touching difficulty more.Dark tongue quality, thin fur, hesitant pulse string.
(1) dialectical: this type is equivalent to the later stage, skin lesion is got blister, and forms ulcer after broken, does not touchingly heal, and dark tongue quality, thin fur, stringy pulse is dialectical main points.
(2) pathogenesis: deficiency of qi and blood, stagnation of QI-blood, blood vessels are obstructed, and meridians intercept, and the mistake of muscle muscles and bones is supported then vesicle and festered, and the random skeleton of flesh forms necrosis, pain.Hesitant pulse string is resembling of stagnation of QI-blood.
Method for the treatment of: benefiting qi and removing blood stasis, saturating pus and pain.
Summary of the invention
The technical problem to be solved in the present invention has two, and one is to provide a kind of Chinese medicine preparation for the treatment of decubital ulcer, and another is the preparation technology of this Chinese medicine preparation of invention, makes this Chinese medicine preparation have good curative effect to decubital ulcer, and preparation efficacy stability, be applicable to amplifying and produce.
For solving the problems of the technologies described above, the technical scheme that inventor adopts is, on the basis of front human therapy decubital ulcer experience and self tcm clinical practice experience for many years, according to the ill feature of modern, again compatibility medical material, and composition proved recipe; Then the use principle of modern Chinese medicine preparation technique and Chinese medicine is fully studied, under the prerequisite of Clinical Laboratory, carry out improving and adjusting to proved recipe, the Chinese prescription that final invention one is brand-new and a set of preparation method, thus obtained Chinese medicine preparation is very remarkable to the therapeutic effect of decubital ulcer.The Chinese prescription of this Chinese medicine preparation is made up of the Chinese crude drug of following weight portion:
Pheretima 12-49 part, white sugar 12-38 part, Radix Angelicae Sinensis 8-28 part, Radix Rehmanniae 7-34 part, Herba Hedyotidis Diffusae 5-19 part, Rhizoma Coptidis 6-21 part, Rhizoma Curcumae Longae 7-24 part, Sanguis Draxonis 8-25 part, Galla Chinensis 11-34 part, Olibanum 3-10 part, Radix Angelicae Dahuricae 5-21 part, Myrrha 7-27 part, Borneolum Syntheticum 4-12 part.
In invention process, preferred two prescription proportionings are out expressed as follows with weight portion respectively:
1, Pheretima 30 parts, white sugar 25 parts, Radix Angelicae Sinensis 18 parts, 20 parts, the Radix Rehmanniae, Herba Hedyotidis Diffusae 12 parts, Rhizoma Coptidis 13 parts, 15 parts, Rhizoma Curcumae Longae, Sanguis Draxonis 16 parts, Galla Chinensis 22 parts, Olibanum 6 parts, the Radix Angelicae Dahuricae 13 parts, Myrrha 17 parts, Borneolum Syntheticum 8 parts.
2, Pheretima 33 parts, white sugar 22 parts, Radix Angelicae Sinensis 14 parts, 22 parts, the Radix Rehmanniae, Herba Hedyotidis Diffusae 13 parts, Rhizoma Coptidis 12 parts, 13 parts, Rhizoma Curcumae Longae, Sanguis Draxonis 15 parts, Galla Chinensis 20 parts, Olibanum 7 parts, the Radix Angelicae Dahuricae 15 parts, Myrrha 15 parts, Borneolum Syntheticum 6 parts.
The preparation method of Chinese medicine preparation of the present invention is following steps:
(1), each taste raw materials such as Pheretima, white sugar, Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, Olibanum, the Radix Angelicae Dahuricae, Myrrha, Borneolum Syntheticum are taken respectively by Chinese prescription of the present invention;
(2), by Pheretima, white sugar, Borneolum Syntheticum pulverize respectively, Pheretima is ground together with white sugar, and Borneolum Syntheticum grinds separately, crosses 60-100 mesh sieve, is mixed to get fine powder, for subsequent use;
(3), by Olibanum, Myrrha pulverize respectively, parch is levigate, crosses 60-100 mesh sieve, is mixed to get fine powder, for subsequent use;
(4), Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, the Radix Angelicae Dahuricae are pulverized and mixed respectively, add the purified water of initial medical material 4-15 times weight, soak 4-24 hour, backflow decocts 1-6 hour, filters, then adds the purified water of initial weight 3-12 times weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.23 is for subsequent use;
(5), the filtering residue of step (4) is added the ethanol of the concentration 60-85% of 5-13 times of weight, reflux, extract, 2 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.23 is for subsequent use;
(6), by the concentrated solution of step (4) and (5) gained merge, add step (2) and step (3) gained fine powder, mix homogeneously, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.45-1.50, for subsequent use;
(7), step (6) gained traditional Chinese medicine thick paste is added suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs, as the dosage form such as unguentum (containing soft extract, ointment, plaster), patch, tincture, powder, oil preparation, medicated wine, membrane, colloid, suppository, spray.
Character effect of the present invention's Chinese crude drug used:
Pheretima: this product is the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb.Salty in the mouth, cold in nature; Return liver, spleen, urinary bladder channel; Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.
White sugar: be the stem juice of grass Caulis Sacchari sinensis, through refining creamy white crystals body.Sweet in the mouth, property is put down; Return spleen, lung meridian; With middle emergency, promote the production of body fluid and moisturize.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
The Radix Rehmanniae: this product is the fresh of scrophulariaceae rehmannia glutinosa plant or dried root.Sweet in the mouth, cold in nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.
Herba Hedyotidis Diffusae: this product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Sweet in the mouth, light, cool in nature; Enter stomach, large intestine, small intestine meridian; Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
Rhizoma Curcumae Longae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae.Acrid in the mouth, hardship, warm in nature; Return spleen, Liver Channel; Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.
Sanguis Draxonis: this product is that the resin that oozes out of babassu Sanguis Draxonis fruit is through being processed into.Sweet in the mouth, salty, property is put down; GUIXIN, Liver Channel; Removing blood stasis and relieving pain, hemostasia and promoting granulation.
Galla Chinensis: this product is the insect gall on Anacardiaceae plant Fructus rhois chinensis, potanin sumac or Radix Rhois Sinicae leaf, is formed primarily of melaphis chinensis Baker parasitism.Sour in the mouth, puckery, cold in nature; Return lung, large intestine, kidney channel; Astringe the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stops blooding, removing dampness sore.
Olibanum: Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii etc., is used as medicine with the oleo-gum-resin that its trunk skin zone wound oozes out.Acrid in the mouth is bitter, warm in nature; Enter the heart, liver, spleen channel; Regulating qi and activating blood, analgesic therapy, chases after poison.
The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae.Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Myrrha: the oleo-gum-resin that Burseraceae bdellium plant myrrh and the trunk skin zone belonging to his kind of plant together ooze out.Bitter in the mouth, property is put down; Enter Liver Channel; Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Borneolum Syntheticum: point BORNEOLUM SYNTHETICUM and Blumeae preparatum Tabellae two class.BORNEOLUM SYNTHETICUM is the Borneolum Syntheticum that raw material synthesizes through chemical method with Oleum Terebinthinae, Camphora etc.; Blumeae preparatum Tabellae is the crystallization of fresh leaf through steam distillation, cooling gained of Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb, also known as " Chinese mugwort powder " or " sheeting ".Acrid in the mouth, hardship, cold nature; GUIXIN, spleen, lung meridian; To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.
The side of the prescription of Chinese medicine preparation of the present invention separates:
This Chinese prescription is with Pheretima, white sugar, the Radix Rehmanniae, Galla Chinensis for monarch drug, heat clearing away dredging collateral, promote the production of body fluid moisturize, clearing away heat and cooling blood, removing dampness sore; With Radix Angelicae Sinensis, Myrrha, Sanguis Draxonis, Herba Hedyotidis Diffusae for ministerial drug, menstruction regulating and pain relieving, detumescence and promoting granulation, removing blood stasis and relieving pain, promoting blood circulation and detoxication; With Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae, Olibanum for adjuvant drug, removing blood stasis circulation of qi promoting, detumescence and apocenosis, analgesic therapy chase after poison; With Rhizoma Coptidis, Borneolum Syntheticum for making medicine, eliminating fire and detoxication, clearing away heat to alleviate pain; The all medicines of monarch coordinate, mutual coordination, negative and positive each other, jointly reach heat clearing away dredging collateral, promote the production of body fluid moisturize, clearing away heat and cooling blood, removing dampness sore, detumescence and promoting granulation, removing blood stasis and relieving pain, removing blood stasis circulation of qi promoting, detumescence and apocenosis, analgesic therapy chase after the effects such as poison, shows excellent curative effect to the treatment of decubital ulcer.
Compared with prior art, Chinese medicine preparation of the present invention is treating in decubital ulcer significant technical advantages such as having instant effect, good effect, do not recur; And this Chinese medicine preparation efficacy stability, low cost of manufacture, social benefit is huge.
Therefore, the present invention's also application of claimed above-mentioned Chinese medicine preparation in the medicine of preparation treatment decubital ulcer.
Detailed description of the invention
Inventors performed a series of practice production, safety and efficiency assay, in order to prove technical advantage of the present invention further.
Embodiment 1
Inventor with several groups of representational prescription proportionings and preferably technological parameter produce ointment, the proportioning of each group is as shown in table 1.
Table 1 is group proportioning raw materials table respectively
(1), each taste raw materials such as Pheretima, white sugar, Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, Olibanum, the Radix Angelicae Dahuricae, Myrrha, Borneolum Syntheticum are taken respectively by proportioning shown in table 1;
(2), by Pheretima, white sugar, Borneolum Syntheticum pulverize respectively, Pheretima is ground together with white sugar, and Borneolum Syntheticum grinds separately, crosses 70 mesh sieves, is mixed to get fine powder, for subsequent use;
(3), by Olibanum, Myrrha pulverize respectively, parch is levigate, crosses 70 mesh sieves, is mixed to get fine powder, for subsequent use;
(4), Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, the Radix Angelicae Dahuricae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 14 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 9 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.23 is for subsequent use;
(5), the filtering residue of step (4) is added the ethanol of the concentration 75% of 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.23 is for subsequent use;
(6), by the concentrated solution of step (4) and (5) gained merge, add step (2) and step (3) gained fine powder, mix homogeneously, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.45-1.50, for subsequent use;
(7), by step (6) gained traditional Chinese medicine thick paste add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make ointment, specification is 0.18g crude drug/g ointment.
Embodiment 2
The irritation test of Chinese medicine preparation of the present invention
1, trial drug: the ointment of what the embodiment of the present invention 1 was produced be numbered A-E, specification is: 0.18g crude drug/g ointment.
2, experimental technique:
Get healthy guinea pig 60, be divided into 6 groups at random, often organize 10, depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, 5 groups of Cavia porcelluss are coated with traditional Chinese herb medicine 2g, 4g and 8g of the present invention respectively, respectively containing crude drug 0.36g, 0.72g and 1.44g, matched group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, put to death by Cavia porcellus, the heart, liver, kidney and depilation skin do pathological examination.
3, result
Above-mentioned 5 groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.Result is pointed out, and Chinese medicine preparation of the present invention, without local irritant effect, also has no general toxicity and Transdermal absorption toxic manifestations.Show Chinese medicine for external application use safety of the present invention.
Embodiment 3
The pharmacodynamic experiment of Chinese medicine preparation of the present invention
(1), test prepares
1, experimental animal: common undercoat Cavia porcellus, male and female half and half, body weight 391 ± 24g; ICR mice, male and female half and half, body weight 24 ± 3g; Be purchased from Beijing HFK Bio-Technology Co., Ltd..
2, trial drug:
Control drug: Xiangpishengji paste, accurate word Z12020345, the packing specification 30g/ box of traditional Chinese medicines, Tianjin Darentang Wanhong Pharmaceutical Co., Ltd.Aspirin enteric-coated slow releasing tablet, the accurate word H20030396 of traditional Chinese medicines, Shandong XinHua Pharmacy stock Co., Ltd.
Investigational agent: the ointment of what the embodiment of the present invention 1 was produced be numbered D and E, specification is 0.18g crude drug/g ointment.
(2), 0.6%HAC is caused to the analgesic activity of mice pain reaction:
Get male and healthy mice 80, be divided into 8 groups at random, with the Effective Component of Chinese Medicine thick paste being numbered D and E obtained by the embodiment of the present invention 1, be modulated into low, in, high dose group (1.8g/kg, 3.6g/kg, 7.2g/kg, be respectively 5 times of quantity, 10 times, 20 times), Xiangpishengji paste group and blank group, Xiangpishengji paste group dosage is 3.6g crude drug/kg/d, blank group gives isopyknic water gastric infusion, 5 groups are all by the volume gastric infusion of 0.25ml/10g body weight, for three days on end, 1 hour lumbar injection 0.6%HAC after mensuration last medicine respectively, 0.1ml/10g Mus is heavy, there is the writhing number of times in the incubation period and 15 minutes of writhing response in record, by formulae discovery pain suppression ratio (%), result with ± SD represents, t inspection between statistical procedures method employing group, result is as shown in table 2.
Suppression ratio (%)=(blank group twisting number of times-administration group twisting number of times) /blank group twisting number of times × 100%
Table 2 Effective Component of Chinese Medicine thick paste of the present invention to 0.6%HAC cause mice pain reaction effect ( ± SD, n=10)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with Xiangpishengji paste group △p < 0.05, △ △p < 0.01.
From table 2 result, the high, medium and low dosage of Effective Component of Chinese Medicine thick paste of the present invention all obviously can suppress the writhing incubation period of mice.The significant difference had in various degree is compared with blank group; The high, medium and low dosage of Effective Component of Chinese Medicine thick paste of the present invention all significantly can reduce the writhing number of times of mice, compares with blank group the significant difference had in various degree, points out Effective Component of Chinese Medicine thick paste of the present invention to have good analgesic activity.From pain suppression ratio result: Chinese medicine system of the present invention three dosage groups are all significantly better than Xiangpishengji paste group.
(3), the antiinflammatory action of Chinese medicine preparation of the present invention
1, the foundation of setting up ACD model of ACD model and medication:
Laboratory animal is in testing abdominal part unhairing the previous day, area 3 × 3cm.The experiment same day and second day are coated with 0.5%DNFB25ul sensitization in unhairing portion, and once a day, within 6th, bring out dermatitis in the left hard of hearing painting 0.2%DNFB20ul of mice, the auris dextra back of the body is coated with substrate 20ul contrast.Bring out administration in latter 6 hours, be applied to left hard of hearing portion, slightly massage, every day 2 times, auris dextra is in kind coated with equivalent Matrix controls.
150 mices are divided into 5 groups at random, often organize 30.Be respectively D ointment group of the present invention, E ointment group, Xiangpishengji paste group, model group and blank group (normal saline group).
2, observation index and method:
Each group of mice will often organize phase point when mice is divided into again 24h, 48h, 72h tri-at random in exciting latter 6 hours for the last time, and time each, phase point is often organized and got 10 at random.Respectively after exciting medication 24h, 48h, 72h break marrow put to death.
(1), ear swelling degree: the thickness in the middle part of vernier caliper measurement mice ears, calculates and bring out rear left auris dextra thickness difference and mice ear degree.
(2), HE dyes observation: get the section of Mus ear tissue routine paraffin wax, HE dyes.There is zero difference with in om observation HE stained with or without between pathological change and each tissue, and observe change and the difference of cell type in stained.
(3), mice left ear skin lesion place tissue adopts the method for SABC, observes the expression of IL-2, IFN-r: the conventional dewaxing embedding of section, dehydration, 3%H 2o 2solution eliminates endogenous peroxidase activity, and the multiple antigen of hot repair, drips 5%BSA confining liquid, then add primary antibodie successively, and biotinylation two resists, and after SABC, DAB develops the color, and haematoxylin is slightly redyed, and dehydration is transparent, mounting, microscopic examination.
(4), serum IL-2 is detected, IFN-r concentration: adopt eyeball excise method to get blood during each phase sacrifice and be about 1.5ml, after leaving standstill 15min, the centrifugal 20min of 3000r/min, separation of serum, be placed in-20 DEG C of refrigerators to be measured, adopt enzyme linked immunosorbent assay (ELISA) to measure Cytokine of Serum IL-2, IFN-γ expression.Strictly press test kit description operation, measure each specimen 450nm place each hole OD value by microplate reader.With OD value for vertical coordinate, standard concentration is abscissa, obtains the content of IL-2, IFN-γ in each sample serum with " CurveExert1.3 " Software on Drawing standard curve.
3, statistical method analysis
This experimental data all adopts SPSS16.0 statistical software to carry out statistical analysis to each sample, detect data results with ± SD represents, compares and adopts LSD method, arrange inspection level α=0.05 between two groups, and P < 0.05 has significance for difference.
4, experimental result
(1), the impact of each process factor on Mus ear thickness is as shown in table 3:
Table 3 respectively group mice different time points ear swelling degree (left ear-auris dextra, unit: um) comparison ( ± SD, n=10)
Note: #P < 0.01 compared with blank group; * P < 0.05, * * P < 0.01 compared with model group; Compared with Xiangpishengji paste group △p < 0.05.
From table 3, the different phase model group of ear swelling degree difference is P < ear swelling degree after 0.05,24 hours, 48 hours, 72 hours compared with blank group, this product D and E ointment group P < 0.01 compared with model group; And each time period this product D ointment group, E ointment group P < 0.05 compared with Xiangpishengji paste group.Traditional Chinese herb medicine of the present invention is significantly better than Xiangpishengji paste ,particularly D ointment group effect is best.
(2), each process factor is to histopathology of skin's impact analysis:
Different time sections naive mice histopathology is without significant change, model group HE stained is visible: between epidermis showed cell and intracellular edema, epidermal cell proliferation, dermal connective tissue edema, can find the infiltration of more Streptococcus and minority polymorphonuclear cell.Vasodilation is congested, and around visible mild inflammatory cell infiltrates.In each processed group mice serum of different time sections, the impact of IL-2, IFN-r content is as shown in table 4, table 5:
In the different phase mice serum of table 4 different pharmaceutical IL-2 concentration (pg/m1) comparison ( ± SD, n=10)
Note: * P < 0.05, * * P < 0.01 compared with model group; Compared with Xiangpishengji paste group △p < 0.05.
In the different phase mice serum of table 5 different pharmaceutical IFN-γ concentration (pg/m1) comparison ( ± SD, n=10)
Note: * P < 0.05, * * P < 0.01 compared with model group; Compared with Xiangpishengji paste group △p < 0.05.
From table 4,5, in the ACD mice serum that this product D ointment group, E ointment group, Xiangpishengji paste group are induced DNFB, IL-2, IFN-γ level all has inhibitory action, and within 48 hours, 72 hours, Xiangpishengji paste group has significant difference (P < 0.05) compared with model group; Each time period this product D ointment group, E ointment group all have pole significant difference (P < 0.01) compared with model group, and have significant difference (P < 0.05) compared with Xiangpishengji paste group.Traditional Chinese herb medicine of the present invention is significantly better than Xiangpishengji paste ,particularly D ointment group effect is best.
5, conclusion
The ointment of what the embodiment of the present invention 1 was produced be numbered D and E obviously can alleviate the swelling of mouse ear, all has downward effect to cytokine in different time sections mice serum, the differentiation of this medicine scalable T cell is described and Be very effective; Ointment of the present invention is significantly better than Xiangpishengji paste in drug effect ,particularly D ointment group effect is best.
(4), on the impact of histamine phosphate's itch-threshold value:
Cavia porcellus 40, is divided into 4 groups at random, is blank group, medicine D group of the present invention, medicine E group and Xiangpishengji paste group.1d before experiment, each group Cavia porcellus right back instep depilation coating 1 time.Experiment is worked as daily coarse sandpaper and is abraded right back instep depilation place epidermis 1cm 2, repaste medicine 1 time, after 20min, in scratch depilation, 0.01% histamine phosphate 0.05ml/ Mus is dripped in district, after this, every 3min successively with 0.02,0.03,0.04,0.05% ... the concentration increased progressively drop to Cavia porcellus later lick right back sufficient time histamine's total amount be itch-threshold value, the results are shown in Table 6.
Table 6 on Cavia porcellus caused by histamine phosphate itch threshold value impact ( ± SD, n=10)
Note: compare with saline control group, * P < 0.05, * * P < 0.01; Compare with Xiangpishengji paste group, △p < 0.01.
No matter as shown in Table 6, compare with normal saline group, be this product D ointment group, E ointment group, or Xiangpishengji paste group, all reaches significant diversity effect to the Cavia porcellus itch-threshold value that histamine phosphate causes, show that three all has good itching-relieving action; Compare with Xiangpishengji paste group, medicine group of the present invention obviously has raising Cavia porcellus itch-threshold value and also reaches extremely significant diversity effect (P < 0.01), point out medicine of the present invention to have good antipruritic ability, this is very effective therapeutical effect for decubital ulcer ,particularly D ointment group effect is best.
Embodiment 4
This clinical trial collect altogether patients with bedsore 158 example, age 24-63 year, wherein man 64 example, female 94 example.All patients are divided into two groups at random, treat 1 group and treatment 2 groups; Treat 1 group of ointment being numbered D using the embodiment of the present invention 1 to produce, every day 2 times, be as the criterion to cover affected part, more than 8 hours, interval; Treat 2 groups of ointments being numbered E using the embodiment of the present invention 1 to produce, every day 2 times, be as the criterion to cover affected part, more than 8 hours, interval.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously.After treatment all terminates, statistics therapeutic outcome is as follows:
Treat 1 group: cure 68 examples, account for 86.1%; Effective 10 examples, account for 12.7%; Invalid 1 example, accounts for 1.3%; Total effective rate is 98.7%;
Treat 2 groups: cure 63 examples, account for 79.8%; Effective 14 examples, account for 17.7%; Invalid 2 examples, account for 2.5%; Total effective rate is 97.5%.
Therapeutic outcome shows, and Chinese medicine preparation prepared by the present invention has very significant curative effect to decubital ulcer, and the total effective rate of two groups is all more than 97.5%, and the cure rate for the treatment of 1 group is up to 86.1%.Therefore, Chinese medicine preparation prepared by the present invention achieves breakthrough technological progress and huge scientific achievement in its field, and it is creative apparent.

Claims (3)

1. prepare a method for the Chinese medicine preparation for the treatment of decubital ulcer, it is characterized in that, described preparation method comprises the following steps:
(1) Pheretima, white sugar, Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, Olibanum, the Radix Angelicae Dahuricae, Myrrha, each taste raw material of Borneolum Syntheticum, is taken;
(2), by Pheretima, white sugar, Borneolum Syntheticum pulverize respectively, Pheretima is ground together with white sugar, and Borneolum Syntheticum grinds separately, crosses 60-100 mesh sieve, is mixed to get fine powder, for subsequent use;
(3), by Olibanum, Myrrha pulverize respectively, parch is levigate, crosses 60-100 mesh sieve, is mixed to get fine powder, for subsequent use;
(4), Radix Angelicae Sinensis, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Rhizoma Coptidis, Rhizoma Curcumae Longae, Sanguis Draxonis, Galla Chinensis, the Radix Angelicae Dahuricae are pulverized and mixed respectively, add the purified water of initial medical material 4-15 times weight, soak 4-24 hour, backflow decocts 1-6 hour, filters, then adds the purified water of initial weight 3-12 times weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.18-1.23 is for subsequent use;
(5), the filtering residue of step (4) is added the ethanol of the concentration 60-85% of 5-13 times of weight, reflux, extract, 2 times, each 1-6 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.18-1.23 is for subsequent use;
(6), by the concentrated solution of step (4) and (5) gained merge, add step (2) and step (3) gained fine powder, mix homogeneously, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.45-1.50, for subsequent use;
(7), by step (6) gained traditional Chinese medicine thick paste add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs.
2. the method for the Chinese medicine preparation of preparation treatment decubital ulcer as claimed in claim 1, it is characterized in that, the weight portion of described each taste raw material is: Pheretima 12-49 part, white sugar 12-38 part, Radix Angelicae Sinensis 8-28 part, Radix Rehmanniae 7-34 part, Herba Hedyotidis Diffusae 5-19 part, Rhizoma Coptidis 6-21 part, Rhizoma Curcumae Longae 7-24 part, Sanguis Draxonis 8-25 part, Galla Chinensis 11-34 part, Olibanum 3-10 part, Radix Angelicae Dahuricae 5-21 part, Myrrha 7-27 part, Borneolum Syntheticum 4-12 part.
3. the method for the Chinese medicine preparation of preparation treatment decubital ulcer as claimed in claim 2, it is characterized in that, the weight portion of described each taste raw material is: Pheretima 30 parts, white sugar 25 parts, Radix Angelicae Sinensis 18 parts, 20 parts, the Radix Rehmanniae, Herba Hedyotidis Diffusae 12 parts, Rhizoma Coptidis 13 parts, 15 parts, Rhizoma Curcumae Longae, Sanguis Draxonis 16 parts, Galla Chinensis 22 parts, Olibanum 6 parts, the Radix Angelicae Dahuricae 13 parts, Myrrha 17 parts, Borneolum Syntheticum 8 parts.
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Publication number Priority date Publication date Assignee Title
CN106943510A (en) * 2017-04-07 2017-07-14 买莹莹 A kind of Chinese medicine composition of pre- counteracting bedsores and preparation method thereof

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CN103272053A (en) * 2013-06-05 2013-09-04 刘建飞 Topical ointment for treating bedsores and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272053A (en) * 2013-06-05 2013-09-04 刘建飞 Topical ointment for treating bedsores and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106943510A (en) * 2017-04-07 2017-07-14 买莹莹 A kind of Chinese medicine composition of pre- counteracting bedsores and preparation method thereof

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