CN105434793A

CN105434793A - Composition for treating psoriasis pustulose and preparation method for composition

Info

Publication number: CN105434793A
Application number: CN201610023124.0A
Authority: CN
Inventors: 王宗山
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-14
Filing date: 2016-01-14
Publication date: 2016-03-30

Abstract

The invention relates to a composition for treating psoriasis pustulose. The composition is prepared from the following main raw materials in weight proportion: 4.5 to 9 parts of golden larch bark, 4.5 to 9 parts of chinaberry bark and root-bark, 3 to 6 parts of honeysuckle, 3 to 6 parts of cassia twig, 3 to 6 parts of natural indigo, 4.5 to 9 parts of Mongolian dandelion herb, 0.9 to 1.5 parts of talcum powder, 9 to 30 parts of indigowoad leaf (preferably 9.5 to 29.5 parts of indigowoad leaf), 9 to 12 parts of herba rhodiolae, 6 to 12 parts of spreading hedyotis herb, 6 to 12 parts of caulis spatholobi, 6 to 12 parts of poria and 6 to 15 parts of bunge corydalis herb. The composition for treating psoriasis pustulose disclosed by the invention is capable of effectively relieving rash symptoms caused by psoriasis pustulose, has the effects of relieving itching and stopping pain, has a very good therapeutic action on psoriasis pustulose, is safe and effective and has no side effects.

Description

A kind of composition and method of making the same for the treatment of psoriasis pustulosa

Technical field

The invention discloses a kind of compositions, especially treat the composition and method of making the same of psoriasis pustulosa.Belong to traditional Chinese medicine field.

Background technology

Pustule (pustule) is a limitation epidermis cavity protuberance, includes muddy pus.System is primary in skin and is formed by papulovesicle differentiation.The pustule size depth not etc., can not have inflammatory blush around, become after shallow pustule is dry pus crusts more after do not stay cicatrix, pustule more deeply can be formed ulcer more after can stay cicatrix.

The cause of disease: the reason occurred as psoriasis pustulosa, still unclear at present, pathogenesis is comparatively complicated, and risk factor is also more, but generally stimulates relevant with medication.Especially in recent years, cause the case of generalized pustular psoriasis to have due to irregular application corticosteroid treatment psoriasis vulgaris and increase trend.As life-time service external glucocorticoid, Salicylates, sun exposure etc.Also after it was observed that primary disease betides upper respiratory tract streptococcal infection, thus think again may with infection relevant.But be not direct infection skin, but the extraordinary reaction of the one of health.In addition, the pustule of this pustule and real bacteriological infection is different.The pustule of bacteriological infection is comparatively large, and isolate, be dispersed in distribution, comparison sheet is shallow, and easily rotten to the corn, there is pus crusts on surface, the clinical impetigo being common in child.The aseptic pustule of psoriasis pustulosa is then less, dense distribution, more deeply, not easily forms rotten to the corn face, has desquamation after pustule is withered.Therefore, psoriasis pustulosa is not bacteriological infection, but a kind of aseptic pustule, and the traditional Chinese medical science thinks the deficiecny of liver-YIN of its basic pathogenic factor or patient.The course of disease of psoriasis pustulosa is longer, and treatment lacks the single dose medicine of determined curative effect, although drug combination can symptom management, some west side effects of pharmaceutical drugs also should not be underestimated, and are easy to recurrence, especially palmar and plantar pustula psoriasis after drug withdrawal.Therefore, Traditional Chinese Medicine experts reminds patient, should comprehensively analyze the state, patient's condition to the treatment of psoriasis pustulosa, removes possible risk factor, avoids pursuing short term effect merely and ignore Western medicine side effect and late result, note locally with the complementarity etc. of systematic treating.

Clinical manifestation: the 1. type that generalized pustular psoriasis is the heaviest clinically, more rare, etiology unknown, in external dripping of irritant drugs, infection, application glucocorticoid or immunosuppressant process, drug withdrawal etc. is precipitating factor suddenly.Fall ill hurried, the high heat of sustainable a few days tension and relaxation, companion's general malaise, weak and arthroncus, erythema occurs suddenly general send out shallow the aseptic pimple of yellow-white, syringe needle, to foxtail millet grain size, is just small pieces, is fused in " pus lake " later, in several weeks can diffusivity distribution whole body, often there is intertrigo, incrustation in pleat portion, the erythema around pustule is often expanded and is fused into the change of erythroderma sample, the visible pimple of mucosa, lingual surface often has comparatively zanjon stricture of vagina, claims fluted tongue.Comparatively can occur together the course of disease finger tip atrophy, myasthenia, total white blood cells increase, hypocalcemia, erythrocyte sedimentation rate speed by elder, even can occur serious systemic lesion and secondary infection.Short-term heating, pustule are often in cyclic recurrence, and spontaneous remission after last for days to several weeks, the general rubescent speckle desquamation of whole body, become Folium Styracis Suberifoliae glass recurrent exerbation like this, cause patient's hypoproteinemia, systemic conditions is poor, prognosis mala.Generalized pustular psoriasis is the system damage such as concurrent liver, kidney usually, also can because of secondary infection, electrolyte disturbance or exhaustion threat to life.2. limitation psoriasis pustulosa erythra is limited to palm and the sufficient sole of the foot, symmetrical.Metacarpus skin lesion onset is in large hypothenar, and later skin lesion gradually expands to the centre of the palm, the back of the hand and finger, and sufficient sole of the foot portion is apt to occur in the middle part of the sole of the foot and inner side, and erythra is that in symmetry erythema, faint yellow syringe needle, to the large pimple of foxtail millet grain, not easily breaks in groups.After about 1-2 weeks, there is new bleb in groups in dry, the incrustation of pustule and desquamation repeatedly under squama, therefore the different times infringement such as visible pustule, incrustation, desquamation on same skin lesion, recurrent exerbation like this, time light time weigh, prolongedly not heal.The pathological changes of patient Chang Banjia, first has pitting, traverse furrow, vertical ridge, first are muddy, an empyema under onycholysis and first.

In the method for existing Chinese medicine psoriasis pustulosa, application publication number CN104435914A(application number 201410659017.8) patent discloses a kind of Chinese medicine for the treatment of psoriasis pustulosa, it is characterized in that the Chinese medicine preparation be made up of the medical material of following weight proportion: Rhizoma Smilacis Glabrae 50-100 part, Rhizoma Smilacis Scobinicaulis 20-30 part, Radix Polygoni Multiflori 20-30 part, Radix Rehmanniae 10-15 part, Herba Plantaginis 10-15 parts, Rhizoma Acori Graminei 10-15 part, Sinomenium acutum 10-15 part, Herba Spirodelae 10-15 part, Radix Glycyrrhizae 6-9 part, Authorization Notice No. CN102716198B(application number 201210052153.1) disclose one and treat psoriatic medicine, it is characterized in that crude drug is: Cortex Meliae, Radix Sophorae Flavescentis, Herba Ranunculi Japonici, salicylic acid, boric acid, benzoic acid, Herba polygoni hydropiperis, the consumption of each crude drug is: Cortex Meliae 15 ~ 25 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Herba Ranunculi Japonici 40 ~ 60 parts, salicylic acid 10 ~ 20 parts, boric acid 15 ~ 25 parts, 3 ~ 8 parts, benzoic acid, Herba polygoni hydropiperis 7 ~ 13 parts, also containing ethanol or rice wine or Chinese liquor, preparation method is: heat to 80 ~ 90 DEG C by ethanol or rice wine or Chinese liquor, soaks crude drug more than 1 hour, and batching is expensive and be not easy to obtain, and preparation method is complicated, and it is external-applied ointment, cures the symptoms, not the disease, and cannot reach the object of radical cure.

Summary of the invention

For the present situation of existing treatment psoriasis pustulosa deficiency, an object of the present invention is to provide a kind of compositions for the treatment of psoriasis pustulosa, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.

Another object of the present invention is just to provide the preparation method of above-mentioned treatment psoriasis pustulosa.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

A kind of compositions for the treatment of psoriasis pustulosa, take off the primary raw material stating weight proportion to be prepared from: Cortex Pseudolaricis 4.5-9 part, Cortex Meliae 4.5-9 part, Flos Lonicerae 3-6 part, Ramulus Cinnamomi 3-6 part, Indigo Naturalis 3-6 part, Herba Taraxaci 4.5-9 part, Pulvis Talci 0.9-1.5 part, Folium Isatidis 9-30 part is (preferred, Folium Isatidis 9.5-29.5 part), Radix Rhodiolae 9-12 part, Herba Hedyotidis Diffusae 6-12 part, Caulis Spatholobi 6-12 part, Poria 6-12 part, Herba Violae 6-15 part, Fructus Toosendan 9-15 part, Herba Menthae 9-15 part, Radix Sophorae Tonkinensis 4-9 part, Radix et Rhizoma Dysosmatis 3-12 part, Herba Agerati Conyzoidis 9-15 part, Aloe juice 20-40 part.

Treat a compositions for psoriasis pustulosa, preferred proportioning, take off the primary raw material stating weight proportion and be prepared from: Cortex Pseudolaricis 5-8 part, Cortex Meliae 5-8 part, Flos Lonicerae 3.5-5 part, Ramulus Cinnamomi 3.5-5 part, Indigo Naturalis 3.5-5 part, Herba Taraxaci 5-8 part, Pulvis Talci 1.0-1.4 part, Folium Isatidis 12-25 part, Radix Rhodiolae 9.5-11 part, Herba Hedyotidis Diffusae 7-11 part, Caulis Spatholobi 7-11 part, Poria 7-11 part, Herba Violae 8-12 part, Fructus Toosendan 10-13 part, Herba Menthae 10-14 part, Radix Sophorae Tonkinensis 5-8 part, Radix et Rhizoma Dysosmatis 4-10 part, Herba Agerati Conyzoidis 10-14 part, Aloe juice 25-35 part.

Treat a compositions for psoriasis pustulosa, more preferably proportioning, take off the primary raw material stating weight proportion and be prepared from: Cortex Pseudolaricis 7 parts, Cortex Meliae 7 parts, Flos Lonicerae 4 parts, Ramulus Cinnamomi 4 parts, Indigo Naturalis 4 parts, Herba Taraxaci 6 parts, Pulvis Talci 1.2 parts, Folium Isatidis 20 parts, Radix Rhodiolae 10 parts, Herba Hedyotidis Diffusae 9 parts, Caulis Spatholobi 8 parts, 9 parts, Poria, Herba Violae 10 parts, Fructus Toosendan 12 parts, Herba Menthae 12 parts, Radix Sophorae Tonkinensis 6 parts, Radix et Rhizoma Dysosmatis 6 parts, Herba Agerati Conyzoidis 12 parts, Aloe juice 30 parts.

Treat a preparation method of composition for psoriasis pustulosa, preparation process is as follows:

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 14-26 minute is soaked with light salt brine, filter, the hot water of soaked crude drug 90-100 DEG C scalds twice, is placed in preheated container, stir-fry 2-6 minute repeatedly, cease fire, put into crude drug weight 0.2-0.4 vinegar doubly, mixing, continue the 5-12 minute that stir-fries, drying in the air coolly grinds to form smalls to cross 80-120 mesh sieve stand-by;

2. by step 1. gained smalls and Indigo Naturalis and Pulvis Talci mix and add Aloe juice, mix thoroughly clockwise, bottle and obtain medicine for external use;

3. with the warm water soaking 33-44 minute of 30-40 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 10-20 minute at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add raw material weight 2-4 rice wine doubly, brewed 2-4 hour, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

Above-mentioned preparation method, 1. step soaks 18-22 minute with light salt brine, filters, and the hot water of soaked crude drug 93-98 DEG C scalds twice (preferably soak 20 minutes with light salt brine, filter, the soaked crude drug hot water of 95 DEG C scalds twice).

Above-mentioned preparation method, 1. step stir-fries 3-5 minute repeatedly, ceases fire, and puts into crude drug weight 0.25-0.35 vinegar doubly (preferably repeatedly stir-fry 4 minutes, cease fire, put into the vinegar of crude drug weight 0.3 times).

Above-mentioned preparation method, is characterized in that, 1. step continues the 7-10 minute that stir-fries, and the cool smalls that grinds to form that dries in the air crosses 90-110 mesh sieve stand-by (preferably continue to stir-fry 8 minutes, dry in the air cool grind to form smalls to cross 100 mesh sieves stand-by).

Above-mentioned preparation method, is characterized in that, with 33-38 DEG C warm water soaking 38-40 minute (being preferably placed in the interior warm water soaking with 35 DEG C of the container of non iron 39 minutes) in the container that 3. step is placed in non iron.

Above-mentioned preparation method, is characterized in that, 3. step is all first be fried open with high heat at every turn, is turning 13-18 at a simmer minute (be all preferably first be fried open with high heat at every turn, turning 15 minutes at a simmer).

Above-mentioned preparation method, is characterized in that, 4. step adds raw material weight 2.5-3.5 rice wine doubly, brewed 2.5-3.5 hour (preferably adding the rice wine of raw material weight 3 times, brewed 3 hours).

Said composition, to the Be very effective of psoriasis pustulosa, not only has antipruritic, that peeling rash etc. controls table disease effect, fundamentally thoroughly can also treat psoriasis pustulosa, and can for the different reason determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of psoriasis pustulosa.The local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.

Treat a compositions for psoriasis pustulosa, the pharmacological effect of each crude drug is respectively:

Cortex Pseudolaricis: have another name called arhat Cortex Pini Massonianae, wattle skin, pseudolaricis,cortex is root bark and the near root bark of Pinaceae Pseudolarix plant golden larch.The property of medicine: root bark is irregular strip, distortion and slightly rolling up, not of uniform size, matter is tough, feeble QI, acrid in the mouth, hardship, warm in nature.Composition: root bark contains pseudolaric acid B, betulic acid, myricetin, amaron alcohol A and B etc.Find according to modern pharmacological research, this medical instrument has effect of antifungal, anticancer, expelling wind and removing dampness, killing parasites for relieving itching, for eczema, and neurodermatitis.

Cortex Meliae: have another name called chinaberry veneer, Ramulus meliae skin is bark and the root bark of Meliaceae melia plant chinaberry and Fructus Toosendan.The property of medicine: dried bark is irregular block lamellar, channel-shaped or half drum, and matter is tough, not frangibility, odorless, and bitter in the mouth is cold in nature.Composition: containing Toosendanin, Melia azedarach L. terpene alcoholic lactone, Melia azedarach L. ketone, isochuanliansu etc.Find according to modern pharmacological research, this medical instrument has effect of anthelmintic, heat clearing away, dampness, for ascariasis, and rubella pruritus, the diseases such as eczema scabies.

Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.

Ramulus Cinnamomi: its nature and flavor are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.

Herba Taraxaci: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Pulvis Talci: sweet, light, cold.Return bladder, lung, stomach warp.Function cures mainly: inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.

Folium Isatidis: bitter in the mouth, cold in nature.Gui Jing: return liver, the heart, stomach, spleen channel.Effect: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Cure mainly: for the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps.

Radix Rhodiolae: nature and flavor: cold, sweet, puckery.Gui Jing: lung meridian.Function cures mainly: have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.

Herba Hedyotidis Diffusae: its patent medicine bitter in the mouth, light, cold in nature.Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if find, Herba Hedyotidis Diffusae compatibility is proper, can treat various diseases.Another name: Herba Hedyotidis Diffusae, tang Huang, Serpentis needle grass, Radix Picriae felterrae, two leaf humulus, spend that cross grass, sharp knife grass, JIAMENGCAO, Herba Otteliae Alismoidis, Serpentis Lei are careless, crane SHECAO in vain.

Caulis Spatholobi: chicken sedan-chair rattan bitter but slightly sweet taste, warm in nature, returns liver, the heart, kidney channel; Caulis Spatholobi red complexion enters blood, and matter profit row is loose; There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation; Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.The waist gonalgia, rheumatic arthralgia, the numb limbs and tense tendons for the treatment of caused by rheumatism, the compatibilities such as normal and Flos Carthami Semen Persicae, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, dysmenorrhea, normal and Rhizoma Cyperi, Herba Leonuri are used together.

Poria: sweet in the mouth, light, property is put down.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.

Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Herba Violae: heat-clearing and toxic substances removing.Control the high heat of epidemic febrile disease irritated, influenza, infectious hepatitis, nephritis, scrofula, parotitis, furuncle and other pyogenic infection.

Fructus Toosendan: return liver, small intestinal, urinary bladder channel.Effect: soothing the liverly to expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing.Cure mainly: for pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.

Herba Menthae: Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.

Radix Sophorae Tonkinensis: be the dry root welding technology of leguminous plant Sophora tonkinensis Gagnep..It is bitter, cold; Poisonous.Have heat-clearing and toxic substances removing, effect of detumescence sore-throat relieving, is usually used in fire-toxin and pents up, tonsillitis sore throat, laryngopharynx swelling and pain, gingivitis, aphtha of the mouth and tongue.

Radix et Rhizoma Dysosmatis: be the root and rhizome of Berberidaceae Dysosma plant Radix et Rhizoma Dysosmatis, Dysosma Pleiantha and dysosma veitchii Fu.Composition: 1. Radix et Rhizoma Dysosmatis rhizome is containing lignanoid: podophyllotoxin, picropodophyllin; Flavonoid: diphyllin kaempferol, Quercetin etc.2. Dysosma Pleiantha rhizome is containing lignanoid: podophyllotoxin, dehydropodophyllotoxin, podophyllotoxone etc.3. dysosma veitchii Fu root is containing deoxypodophyllotoxin ,-peltain, podophyllotoxin, kaempferol-3--D-Glucose glycosides, glucose, sucrose and-sitosterol.The property of medicine: bitter, pungent, temperature.Poisonous.Return lung, Liver Channel.Function cures mainly: removing toxic substances of reducing phlegm, eliminating stasis and resolving masses.Cure mainly cough, laryngopharynx swelling and pain, scrofula, goiter, nameless gall, herpes zoster, venom, traumatic injury, rheumatic arthralgia.

Herba Agerati Conyzoidis: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb is containing flavonoid: Herba Agerati Conyzoidis flavone A, B, C, Nobiletin, senensetin, lindera pyrite B, etc.Alkaloid: Lycopodium clavatum amine, Echinatin.Triterpenoid compound: freidelin.Sterols: stigmasterol etc.Volatile oil: Herba Agerati Conyzoidis chromene, coumarin etc.Aerial parts contains chromene class: 7-methoxyl group-2,2-dimethyl chromogen alkene, 7,8-dimethoxy-2 etc.The property of medicine: micro-hardship, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, hemostasis, pain relieving.Cure mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, spitting of blood, epistaxis, metrorrhagia, epigastric pain, rheumatic arthralgia, traumatic injury, traumatic hemorrhage, thrush, carbuncle furuncle, eczema pruritus.

Aloe juice: moisturizing: be rich in native physiological water, mineral and lignin, permeability is extremely strong, as skin bottommost layer through as sponge sucks in water, directly moisture needed for supplementary skin, is the skin moisturizing product that can not be substituted.Brighten moisturizing: be rich in several amino acids and natural whiting Moisture factor, can be directly absorbed by the skin, decompose and conversion pigmentation, reach nature moisturizing whitening.Defying age: be rich in monosaccharide and polysaccharide, vitamin and mineral, have obvious therapeutic effect to the aging of cell, reduces the generation of wrinkle.Antiinflammatory, sterilization, mosquito proof are bitten, pain relieving, toxin expelling element: be rich in aloe-emodin and Anthraquinone Complex, external application, extremely strong to promotion wound-healing abilities, do not stay bar trace after extensive wound healing; Repair damaged skin, the irritating acne for the treatment of teenager and acne, and the impression that acne and acne stay, evident in efficacy.

The present composition is based on the principle of traditional Chinese medical herbal treatment psoriasis pustulosa.The Chinese medicinal material selected has toxin expelling, removing heat from blood, the effect of heat of dispelling, and cheap, and life-time service also can not cause the financial burden of patient, is treat the ideal medicine of psoriasis pustulosa.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1: a kind of compositions for the treatment of psoriasis pustulosa, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Cortex Pseudolaricis 4.5 grams, Cortex Meliae 4.5 grams, Flos Lonicerae 3 grams, Ramulus Cinnamomi 3 grams, Indigo Naturalis 3 grams, Herba Taraxaci 4.5 grams, Pulvis Talci 0.9 gram, Folium Isatidis 9 grams, Radix Rhodiolae 9 grams, Herba Hedyotidis Diffusae 6 grams, Caulis Spatholobi 6 grams, 6 grams, Poria, Herba Violae 6 grams, Fructus Toosendan 9 grams, Herba Menthae 9 grams, Radix Sophorae Tonkinensis 4 grams, Radix et Rhizoma Dysosmatis 3 grams, Herba Agerati Conyzoidis 9 grams, Aloe juice 20 parts.

The preparation method of the compositions of above-mentioned treatment psoriasis pustulosa, step is as follows:

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 14 minutes are soaked with light salt brine, filter, the soaked crude drug hot water of 90 DEG C scalds twice, is placed in preheated container, repeatedly stir-fry 2 minutes, cease fire, put into the vinegar of crude drug weight 0.2 times, mixing, continue to stir-fry 5 minutes, drying in the air coolly grinds to form smalls to cross 80 mesh sieves stand-by;

3. with the warm water soaking 33 minutes of 30 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 10 minutes at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add the rice wine of raw material weight 2 times, brewed 2 hours, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

model case one:gold XX, female, 40 years old, people from Linyi.Symptom: head has point erythema, scurf, also there is erythema, the scurf of size as copper coin afterwards with it, symptom develops into whole body very soon subsequently at property aseptic pimple for yellow-white shallow, and the erythema of extremity, scurf are ined succession picture map, and pruritus is hard to bear, scratching and grab rear bloodstained, painful very much, is psoriasis pustulosa through hospital diagnosis, the money flower very much for the treatment of, but Relapse rate difficulty is more.

Use embodiment 1 resulting composition, orally add external, use same day pruritis to alleviate; Use 10 days scurfs obviously to reduce, pruritis disappears, and pimple alleviates the disappearance had; Two weeks scurf is used to disappear more than half; Use again the present composition to consolidate 10 days, drug withdrawal is so far without recurrence.

embodiment 2:treat a compositions for psoriasis pustulosa, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Cortex Pseudolaricis 5 grams, Cortex Meliae 5 grams, Flos Lonicerae 3.5 grams, Ramulus Cinnamomi 3.5 grams, Indigo Naturalis 3.5 grams, Herba Taraxaci 5 grams, Pulvis Talci 1.0 grams, Folium Isatidis 12 grams, Radix Rhodiolae 9.5 grams, Herba Hedyotidis Diffusae 7 grams, Caulis Spatholobi 7 grams, 7 grams, Poria, Herba Violae 8 grams, Fructus Toosendan 10 grams, Herba Menthae 10 grams, Radix Sophorae Tonkinensis 5 grams, Radix et Rhizoma Dysosmatis 4 grams, Herba Agerati Conyzoidis 10 grams, Aloe juice 40 parts.

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 26 minutes are soaked with light salt brine, filter, the soaked crude drug hot water of 100 DEG C scalds twice, is placed in preheated container, repeatedly stir-fry 6 minutes, cease fire, put into the vinegar of crude drug weight 0.4 times, mixing, continue to stir-fry 12 minutes, drying in the air coolly grinds to form smalls to cross 120 mesh sieves stand-by;

3. with the warm water soaking 44 minutes of 40 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 20 minutes at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add the rice wine of raw material weight 4 times, brewed 4 hours, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

embodiment 3:treat a compositions for psoriasis pustulosa, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Cortex Pseudolaricis 8 grams, Cortex Meliae 8 grams, Flos Lonicerae 5 grams, Ramulus Cinnamomi 5 grams, Indigo Naturalis 5 grams, Herba Taraxaci 8 grams, Pulvis Talci 1.4 grams, Folium Isatidis 25 grams, Radix Rhodiolae 11 grams, Herba Hedyotidis Diffusae 11 grams, Caulis Spatholobi 11 grams, 11 grams, Poria, Herba Violae 12 grams, Fructus Toosendan 13 grams, Herba Menthae 14 grams, Radix Sophorae Tonkinensis 8 grams, Radix et Rhizoma Dysosmatis 10 grams, Herba Agerati Conyzoidis 14 grams, Aloe juice 25 parts.

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 18 minutes are soaked with light salt brine, filter, the soaked crude drug hot water of 93 DEG C scalds twice, is placed in preheated container, repeatedly stir-fry 3 minutes, cease fire, put into the vinegar of crude drug weight 0.25 times, mixing, continue to stir-fry 7 minutes, drying in the air coolly grinds to form smalls to cross 90 mesh sieves stand-by;

3. with the warm water soaking 38 minutes of 33 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 13 minutes at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add the rice wine of raw material weight 2.5 times, brewed 2.5 hours, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

embodiment 4: a kind of compositions for the treatment of psoriasis pustulosa, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Cortex Pseudolaricis 9 grams, Cortex Meliae 9 grams, Flos Lonicerae 6 grams, Ramulus Cinnamomi 6 grams, Indigo Naturalis 6 grams, Herba Taraxaci 9 grams, Pulvis Talci 1.5 grams, Folium Isatidis 30 grams, Radix Rhodiolae 12 grams, Herba Hedyotidis Diffusae 12 grams, Caulis Spatholobi 12 grams, 12 grams, Poria, Herba Violae 15 grams, Fructus Toosendan 15 grams, Herba Menthae 15 grams, Radix Sophorae Tonkinensis 9 grams, Radix et Rhizoma Dysosmatis 12 grams, Herba Agerati Conyzoidis 15 grams, Aloe juice 35 parts.

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 22 minutes are soaked with light salt brine, filter, the soaked crude drug hot water of 98 DEG C scalds twice, is placed in preheated container, repeatedly stir-fry 5 minutes, cease fire, put into the vinegar of crude drug weight 0.35 times, mixing, continue to stir-fry 10 minutes, drying in the air coolly grinds to form smalls to cross 110 mesh sieves stand-by;

3. with the warm water soaking 40 minutes of 38 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 18 minutes at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add the rice wine of raw material weight 3.5 times, brewed 3.5 hours, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

model case two:liu XX, female, 25 years old, people from Linyi, originally the pimple just having some slight on ancon and arm, afterwards due to malpractice, caused that sb.'s illness took a turn for the worse in a short period of time, present whole body is all red pimple, surface has multilamellar silvery white flakey scurf, pruritus, pain from head to foot, whole body desquamation, local, with skin lesion (festering) phenomenon, goes examination in hospital to be diagnosed as psoriasis pustulosa.

Use embodiment 4 resulting composition, orally add external, use the same day, the itch symptom of pain of skin focus place is obviously improved; Use 3 days skin lesion (festering) positions to be clearly better, dermatitis, pimple etc. are controlled; Use 7 days skin lesion (festering) positions to heal completely, dermatitis, pimple disappear most; Use 15 days, dermatitis, pimple disappear completely, recover; Rear suggestion its singly take medicine and consolidate 5 days, drug withdrawal so far without recurrence, appearance without any side effects between the operating period.

embodiment 5:treat a compositions for psoriasis pustulosa, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Cortex Pseudolaricis 7 parts, Cortex Meliae 7 parts, Flos Lonicerae 4 parts, Ramulus Cinnamomi 4 parts, Indigo Naturalis 4 parts, Herba Taraxaci 6 parts, Pulvis Talci 1.2 parts, Folium Isatidis 20 parts, Radix Rhodiolae 10 parts, Herba Hedyotidis Diffusae 9 parts, Caulis Spatholobi 8 parts, 9 parts, Poria, Herba Violae 10 parts, Fructus Toosendan 12 parts, Herba Menthae 12 parts, Radix Sophorae Tonkinensis 6 parts, Radix et Rhizoma Dysosmatis 6 parts, Herba Agerati Conyzoidis 12 parts, Aloe juice 30 parts.

1. Cortex Pseudolaricis, Cortex Meliae, Flos Lonicerae, Ramulus Cinnamomi, Herba Taraxaci, Folium Isatidis and Herba Menthae are together shredded, 20 minutes are soaked with light salt brine, filter, the soaked crude drug hot water of 95 DEG C scalds twice, is placed in preheated container, repeatedly stir-fry 4 minutes, cease fire, put into the vinegar of crude drug weight 0.3 times, mixing, continue to stir-fry 8 minutes, drying in the air coolly grinds to form smalls to cross 100 mesh sieves stand-by;

3. with the warm water soaking 39 minutes of 35 DEG C in container Radix Rhodiolae, Herba Hedyotidis Diffusae, Caulis Spatholobi, Poria, Herba Violae, Fructus Toosendan, Radix Sophorae Tonkinensis, Radix et Rhizoma Dysosmatis and Herba Agerati Conyzoidis being placed in non iron, decoct twice, each is all first be fried open with high heat, turning 15 minutes at a simmer, filter, twice filtrate mixing, filtering residue is stand-by;

4. by step 3. gained filtering residue be placed in transparent vessel, add the rice wine of raw material weight 3 times, brewed 3 hours, filter, filtering residue is fried to crisp, grind to form smalls and step 3. gained filtrate mix, decoct and stir into thick paste and put into Mel and stir evenly, repeatedly rub, be twisted into medicated strip, cutting in bulk, is kneaded into grain, is prepared into capsule namely obtains oral medicine according to the processing technique subpackage of capsule.

Using method: for making the present invention reach optimum therapeuticing effect, the present composition, external used medicine gets 3g at every turn, mixes thoroughly with the hot water of 10g, accounts for wiping affected part by swab stick, each 2 of oral capsule, three times on the one, warm water delivery service.

experimental example 1:the clinical practice of the drop of embodiment 5 gained treatment psoriasis pustulosa: screen 300 routine patients in 4 hospitals, before test 2 days, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group uses embodiment 5 products obtained therefrom, and matched group uses other medicine.

Curative effect situation criterion: effectively: after taking this product, malaise symptoms disappears; Invalid: after taking this product, health is unchanged.Result is as shown in table 1.

Table 1:

Prove through clinical trial, the present composition is on treatment psoriasis pustulosa, effective percentage is 98%, cure rate is 95%, uses the present composition, can effectively alleviate the pruritis caused by psoriasis pustulosa, alleviate safely the misery of patient fast, and relapse rate is low, not occurring a routine side effect case in clinical, is a kind of compositions of safer effective treatment psoriasis pustulosa.

Claims

1. treat the compositions of psoriasis pustulosa for one kind, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Pseudolaricis 4.5-9 part, Cortex Meliae 4.5-9 part, Flos Lonicerae 3-6 part, Ramulus Cinnamomi 3-6 part, Indigo Naturalis 3-6 part, Herba Taraxaci 4.5-9 part, Pulvis Talci 0.9-1.5 part, Folium Isatidis 9-30 part is (preferred, Folium Isatidis 9.5-29.5 part), Radix Rhodiolae 9-12 part, Herba Hedyotidis Diffusae 6-12 part, Caulis Spatholobi 6-12 part, Poria 6-12 part, Herba Violae 6-15 part, Fructus Toosendan 9-15 part, Herba Menthae 9-15 part, Radix Sophorae Tonkinensis 4-9 part, Radix et Rhizoma Dysosmatis 3-12 part, Herba Agerati Conyzoidis 9-15 part, Aloe juice 20-40 part.

2. the compositions for the treatment of psoriasis pustulosa according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Pseudolaricis 5-8 part, Cortex Meliae 5-8 part, Flos Lonicerae 3.5-5 part, Ramulus Cinnamomi 3.5-5 part, Indigo Naturalis 3.5-5 part, Herba Taraxaci 5-8 part, Pulvis Talci 1.0-1.4 part, Folium Isatidis 12-25 part, Radix Rhodiolae 9.5-11 part, Herba Hedyotidis Diffusae 7-11 part, Caulis Spatholobi 7-11 part, Poria 7-11 part, Herba Violae 8-12 part, Fructus Toosendan 10-13 part, Herba Menthae 10-14 part, Radix Sophorae Tonkinensis 5-8 part, Radix et Rhizoma Dysosmatis 4-10 part, Herba Agerati Conyzoidis 10-14 part, Aloe juice 25-35 part.

3. the compositions for the treatment of psoriasis pustulosa according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Pseudolaricis 7 parts, Cortex Meliae 7 parts, Flos Lonicerae 4 parts, Ramulus Cinnamomi 4 parts, Indigo Naturalis 4 parts, Herba Taraxaci 6 parts, Pulvis Talci 1.2 parts, Folium Isatidis 20 parts, Radix Rhodiolae 10 parts, Herba Hedyotidis Diffusae 9 parts, Caulis Spatholobi 8 parts, 9 parts, Poria, Herba Violae 10 parts, Fructus Toosendan 12 parts, Herba Menthae 12 parts, Radix Sophorae Tonkinensis 6 parts, Radix et Rhizoma Dysosmatis 6 parts, Herba Agerati Conyzoidis 12 parts, Aloe juice 30 parts.

4. the preparation method of composition of the treatment psoriasis pustulosa according to any one of claim 1-3, is characterized in that: step is as follows:

5. preparation method according to claim 4, it is characterized in that: 1. step soaks 18-22 minute with light salt brine, filter, the hot water of soaked crude drug 93-98 DEG C scalds and (preferably soaks 20 minutes with light salt brine twice, filter, the soaked crude drug hot water of 95 DEG C scalds twice).

6. preparation method according to claim 4, is characterized in that: 1. step stir-fries 3-5 minute repeatedly, ceases fire, and puts into crude drug weight 0.25-0.35 vinegar doubly (preferably repeatedly stir-fry 4 minutes, cease fire, put into the vinegar of crude drug weight 0.3 times).

7. preparation method according to claim 4, it is characterized in that: it is characterized in that, 1. step continues the 7-10 minute that stir-fries, and the cool smalls that grinds to form that dries in the air crosses 90-110 mesh sieve stand-by (preferably continue to stir-fry 8 minutes, dry in the air cool grind to form smalls to cross 100 mesh sieves stand-by).

8. preparation method according to claim 4, is characterized in that: it is characterized in that, with 33-38 DEG C warm water soaking 38-40 minute (being preferably placed in the interior warm water soaking with 35 DEG C of the container of non iron 39 minutes) in the container that 3. step is placed in non iron.

9. preparation method according to claim 4, is characterized in that: it is characterized in that, 3. step is all first be fried open with high heat at every turn, is turning 13-18 at a simmer minute (be all preferably first be fried open with high heat at every turn, turning 15 minutes at a simmer).

10. preparation method according to claim 4, is characterized in that: it is characterized in that, 4. step adds raw material weight 2.5-3.5 rice wine doubly, brewed 2.5-3.5 hour (preferably adding the rice wine of raw material weight 3 times, brewed 3 hours).