CN105434563A - Preparation method of oral liquid for treating hyperplasia of mammary glands - Google Patents

Preparation method of oral liquid for treating hyperplasia of mammary glands Download PDF

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Publication number
CN105434563A
CN105434563A CN201510953526.6A CN201510953526A CN105434563A CN 105434563 A CN105434563 A CN 105434563A CN 201510953526 A CN201510953526 A CN 201510953526A CN 105434563 A CN105434563 A CN 105434563A
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parts
oral liquid
lixiviate
preparation
extraction
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韦盛盟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
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  • Mycology (AREA)
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  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a preparation method of an oral liquid for treating hyperplasia of mammary glands. The preparation method comprises the following steps: step one, carrying out extraction, and drying and grinding a traditional Chinese medicine composition to obtain raw material powder, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18 to 22 parts of white peony root, 13 to 18 parts of deep-fried bighead atractylodes rhizome, 8 to 12 parts of deep fried medicated leaven, 5 to 8 parts of rhizoma bolbostemmae, 8 to 12 parts of tetrapanax papyriferus, 8 to 12 parts of cowherb seed, 4 to 6 parts of trichosanthes kirilowii, 8 to 12 parts of turtle shell, 8 to 12 parts of red peony root, 8 to 12 parts of root of kudzu vine, and 8 to 12 parts of dahurian angelica root; step two, mixing the raw material powder with an ethanol solution (60-70%) according to a volume ratio of 1:10-30, carrying out extraction, after extraction, and heating the solution to evaporate ethanol to obtain extract; step three, adding distilled water to dilute the extract to obtain the oral liquid, wherein the weight ratio of the extract to the distilled water is 1:5-8.

Description

A kind of preparation method for the treatment of the oral liquid of cyclomastopathy
Technical field
The present invention relates to tcm field, particularly relate to a kind of preparation method for the treatment of the oral liquid of cyclomastopathy.
Background technology
Breast nodule is mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, and its pathogenic factor is mainly due to endocrine hormone imbalance.Mainly with breast, periodically pain is for feature, and patient often has lump in breast, and only touches the corpus mamma thickened during clinical examination, also has nipple discharge individually.Originally breast nodule disease is often the unrestrained property distending pain of trip, and touch a tender spot for the outer upside of breast and middle and upper part are obvious, monthly premenstrual pain aggravation, after passing through, pain goes down or disappears.Severe patient premenstrual through after all in rest pain.Sometimes pain is to armpit, the radiation of the shoulder place such as back, upper limb.
Modern medicine is thought: the external environment of marriage and childbirth, meals, people living and inherited genetic factors are the main causes of mammary gland morbidity.
At present, for breast nodule disease, generally take dietetic therapy, massage, acupuncture or the treatment of the method such as chemistry or oral antibiotic medicine, but general chemistry or antibiotic medicine only can reach the order ground controlling symptom, can not effect a radical cure, and side effect are large.At present, the pure Chinese medicine ingredients oral liquid effectively can treating cyclomastopathy is not also had.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and/or defect, and the advantage will illustrated at least is below provided.
Another object of the present invention is to provide a kind of preparation method for the treatment of the oral liquid of cyclomastopathy, can be effectively treated cyclomastopathy oral liquid.
Other objects with some for achieving the above object, the present invention adopts following technical scheme
Treat a preparation method for the oral liquid of cyclomastopathy, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Radix Paeoniae Alba 18-22, Rhizoma Atractylodis Macrocephalae preparata 13-18, Massa Medicata Fermentata (parched to brown) 8-12, Rhizoma Bolbostematis 5-8, Medulla Tetrapanacis 8-12, Semen Vaccariae 8-12, Chinese juniper beach wormwood 4-6, Carapax Trionycis 8-12, Radix Paeoniae Rubra 8-12, Radix Puerariae 8-12 and Radix Angelicae Dahuricae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 5-8 doubly, obtain described treatment cyclomastopathy oral liquid.
Preferably, in the preparation method of the oral liquid of described treatment cyclomastopathy, in step 3 to treatment cyclomastopathy oral liquid in add the maltose alcohol of 5-8%.
Preferably, in the preparation method of the oral liquid of described treatment cyclomastopathy, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
The present invention at least comprises following beneficial effect: first, and the present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of breast nodule is: stagnation of liver-QI violates stomach against gas, dysfunction of the spleen in transportation, the turbid interior life of expectorant, blocks stomach network, pents up in breast, gather as tuberosity.In Chinese medicine composition of the present invention, the Radix Paeoniae Alba, soothing the liverly nourishes blood; Rhizoma Atractylodis Macrocephalae preparata, strengthening the spleen and stomach, dehumidifying reduce phlegm; Massa Medicata Fermentata (parched to brown), invigorating the spleen and regulating the stomach; Rhizoma Bolbostematis, removing toxic substances, eliminating stagnation, detumescence; Medulla Tetrapanacis, Semen Vaccariae, activating collaterals and eliminating stagnation; Chinese juniper beach wormwood, reduces phlegm; Carapax Trionycis, hard masses softening and resolving; Radix Paeoniae Rubra, eliminating stasis to stop pain; Radix Puerariae, priming enter Yangming Channel double lightly float disperse, eliminating stagnation; The Radix Angelicae Dahuricae, reducing swelling and alleviating pain.The present invention, by adjusting liver reason stomach, resolving phlegm and softening hard masses, activating collaterals and eliminating stagnation, makes breast nodule be cured.
Secondly, by can effectively treat cyclomastopathy Chinese medicine composition carry out substep alcohol steep, make the oral liquid not only taking convenience of prepared treatment cyclomastopathy, and be conducive to the absorption of effective ingredient, effectively treat cyclomastopathy.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below the present invention is elaborated, can implement according to this after consulting this description to make those of ordinary skill in the art.
Treat a preparation method for the oral liquid of cyclomastopathy, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Radix Paeoniae Alba 18-22, Rhizoma Atractylodis Macrocephalae preparata 13-18, Massa Medicata Fermentata (parched to brown) 8-12, Rhizoma Bolbostematis 5-8, Medulla Tetrapanacis 8-12, Semen Vaccariae 8-12, Chinese juniper beach wormwood 4-6, Carapax Trionycis 8-12, Radix Paeoniae Rubra 8-12, Radix Puerariae 8-12 and Radix Angelicae Dahuricae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 5-8 doubly, obtain described treatment cyclomastopathy oral liquid.
The present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of breast nodule is: stagnation of liver-QI violates stomach against gas, dysfunction of the spleen in transportation, the turbid interior life of expectorant, blocks stomach network, pents up in breast, gather as tuberosity.In Chinese medicine composition of the present invention, the Radix Paeoniae Alba, soothing the liverly nourishes blood; Rhizoma Atractylodis Macrocephalae preparata, strengthening the spleen and stomach, dehumidifying reduce phlegm; Massa Medicata Fermentata (parched to brown), invigorating the spleen and regulating the stomach; Rhizoma Bolbostematis, removing toxic substances, eliminating stagnation, detumescence; Medulla Tetrapanacis, Semen Vaccariae, activating collaterals and eliminating stagnation; Chinese juniper beach wormwood, reduces phlegm; Carapax Trionycis, hard masses softening and resolving; Radix Paeoniae Rubra, eliminating stasis to stop pain; Radix Puerariae, priming enter Yangming Channel double lightly float disperse, eliminating stagnation; The Radix Angelicae Dahuricae, reducing swelling and alleviating pain.The present invention, by adjusting liver reason stomach, resolving phlegm and softening hard masses, activating collaterals and eliminating stagnation, makes breast nodule be cured.
The present invention by can effectively treat cyclomastopathy Chinese medicine composition carry out substep alcohol steep, make the oral liquid not only taking convenience of prepared treatment cyclomastopathy, and be conducive to the absorption of effective ingredient, effectively treat cyclomastopathy.
In described Chinese medicine composition, also comprise the component of following weight portion: Pumex 4-8, Bombyx Batryticatus 8-10, Caulis Lonicerae 8-12 and Herba Taraxaci 8-12.Pumex, salty-cold, removing heat from the lung and dissipating phlegm, hard masses softening and resolving; Bombyx Batryticatus, detoxicating and resolving stagnation of pathogens, resolving phlegm and softening hard masses; Caulis Lonicerae, removing toxic substances, dispelling wind dredging collateral; Herba Taraxaci, removing toxic substances, detumescence core.
In the preparation method of the oral liquid of described treatment cyclomastopathy, in step 3 to treatment cyclomastopathy oral liquid in add the maltose alcohol of 5-8%.
In the preparation method of the oral liquid of described treatment cyclomastopathy, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
Substep lixiviate can make effective ingredient more fully discharge, and improves curative effect of medication.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.

Claims (3)

1. treat a preparation method for the oral liquid of cyclomastopathy, it is characterized in that, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Radix Paeoniae Alba 18-22, Rhizoma Atractylodis Macrocephalae preparata 13-18, Massa Medicata Fermentata (parched to brown) 8-12, Rhizoma Bolbostematis 5-8, Medulla Tetrapanacis 8-12, Semen Vaccariae 8-12, Chinese juniper beach wormwood 4-6, Carapax Trionycis 8-12, Radix Paeoniae Rubra 8-12, Radix Puerariae 8-12 and Radix Angelicae Dahuricae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 5-8 doubly, obtain the oral liquid of described treatment cyclomastopathy.
2. the preparation method of the oral liquid for the treatment of cyclomastopathy as claimed in claim 1, is characterized in that, in step 3 to treatment cyclomastopathy oral liquid in add the maltose alcohol of 5-8%.
3. the preparation method of the oral liquid for the treatment of cyclomastopathy as claimed in claim 1, is characterized in that, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
CN201510953526.6A 2015-12-19 2015-12-19 Preparation method of oral liquid for treating hyperplasia of mammary glands Pending CN105434563A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523865A (en) * 2014-12-17 2015-04-22 蒋树侠 Medicine for treating breast diseases
CN104784660A (en) * 2015-04-16 2015-07-22 文道芬 Stasis removing soup for lobular hyperplasia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523865A (en) * 2014-12-17 2015-04-22 蒋树侠 Medicine for treating breast diseases
CN104784660A (en) * 2015-04-16 2015-07-22 文道芬 Stasis removing soup for lobular hyperplasia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
孙杨: "乳腺增生病中药用药规律分析", 《山东中医杂志》 *

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Application publication date: 20160330