CN105412704A - Method for preparing Chinese herbal preparation for treating erysipelas - Google Patents

Method for preparing Chinese herbal preparation for treating erysipelas Download PDF

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CN105412704A
CN105412704A CN201510981926.8A CN201510981926A CN105412704A CN 105412704 A CN105412704 A CN 105412704A CN 201510981926 A CN201510981926 A CN 201510981926A CN 105412704 A CN105412704 A CN 105412704A
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parts
radix
raw material
material powder
chinese medicine
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刘学键
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Qingdao Huazhicao Medical Technology Co Ltd
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Qingdao Huazhicao Medical Technology Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a method for preparing a Chinese herbal preparation for treating erysipelas and belongs to the technical field of traditional Chinese medicine. The method comprises the steps of conducting alcohol extraction on fructus forsythia, golden cypress, philippine violet herb and radix sophorae flavescentis to obtain thick paste; distilling honeysuckle, common peony roots, radix rehmanniae preparata, scrophularia ningpoensis, moutan bark and liquidambar formosana hance to obtain volatile oil, then adding beta-cyclodextrin, and conducting treatment to obtain raw material powder a; conducting microwave extraction on cinnamon, semen brassicae, bidentate achyranthes roots, rhizoma alismatis, radix bupleuri, gentian, coix seeds, wild chrysanthemum flower, flos carthami and liquorice to obtain a concentrated solution, making the concentrated solution into thick paste to be mixed with the thick paste obtained through alcohol extraction of fructus forsythia, golden cypress, philippine violet herb and radix sophorae flavescentis, and conducting treatment to obtain raw material powder b; smashing cornu cervi degelatinatum, conducting grinding and mesh sieving to obtain raw material powder c; evenly mixing the raw material powder a, the raw material powder b and the raw material powder c, and adding auxiliary materials to obtain the finished preparation. Compared with the prior art, the Chinese herbal preparation can be carried and taken conveniently, the process is simple and easy to conduct, and wide-range application and popularization are facilitated; besides, the Chinese herbal preparation has a good curative effect on erysipelas, and the cure rate is high.

Description

A kind of method preparing the Chinese medicine preparation for the treatment of erysipelas
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of method preparing the Chinese medicine preparation for the treatment of erysipelas.
Background technology
Doctor trained in Western medicine is thought, erysipelas (erysipelas) is that one involves the vasculolymphatic infection of high dermis, and Main Pathogenic Bacteria is A group β Hemolytic streptococcus.Risk factor is below surgical wound or nostril, external auditory meatus, ear-lobe, anus, crack between penis and toe.Any inflammation of skin, especially has and to chap or the inflammation of ulcer is the approach that pathogenic bacterium provide intrusion.Minor abrasions or scratch, damage beyond head, uncleanly ligature of the cord, prophylactic immunization and chronic calf ulcer all may cause this sick.Pathogenic bacterium can hide in intralymphatic, cause recurrence.
The traditional Chinese medical science is thought, erysipelas is because ferritic blood system has heat, and outward by fire-toxin, pyretic toxicity pents up, strongly fragrant resistance skin and sending out; Or due to mucocutaneous broken wound (tinea pedis is rotten to the corn, insect-bite, ecthyma etc. for wound as broken in nasal membrane, ear channel skin or scalp, skin abrasion), the intrusion of taking advantage of a loophole of malicious heresy forms.In Head And Face person, hold wind heat under the arm for all; Send out in Xiong Fu waist crotch person, held liver-fire under the arm; Send out in lower limb person, held under the arm damp and hot; Send out in neonate person, how caused by fetal heat in pregnancy fire-toxin.Main differentiation of symptoms and signs for classification of syndrome is as follows:
1, wind heat fire-toxin type
Card is shown in: erythra betides Head And Face, with aversion to cold or shiver with cold, and high heat, headache, general malaise, nausea and vomiting, indigestion and loss of appetite, thirsty, dry pharynx, yellowish or reddish urine, constipation with dry stool.Red tongue, yellow and thin fur, floating and rapid pulse or big vast number.
Method for the treatment of: clearing away heat,cooling blood and removing toxin, helps to dispel the wind.
2, liver and gall fire Sheng type
Card is shown in: erythra betides Xie Xia waist crotch, becomes large lamellar.With heating, aversion to cold, bitter taste, dry pharynx, conjunctival congestion, breast side of body portion pain, oliguria with reddish urine, constipation.Red tongue, yellow fur or yellow greasy, wiry and frequent pulse or stringy and rolling pulse number.
Method for the treatment of: removing fire from the liver, dampness removing heat.
3, fire-toxin wetness type
Card is shown in: erythra betides shank, dorsal portion, or and water breakthrough bleb, bulla.With aversion to cold, heating, lassitude and weak, headache, indigestion and loss of appetite.Red tongue, yellow and greasy fur, soft and rapid pulse.
Method for the treatment of: clearing away heat-damp and promoting diuresis detoxifies.
4, swaged in pyretic toxicity
Card is shown in: patient's condition is hurried, the performance apart from erythra outer (in Head And Face person, evil malicious inside fire attack more easily occurring to send out), and sees shiver with cold, high heat, irritated, coma, delirium.Deep red tongue, yellow fur or yellow rough, full and rapid pulse or stringy and rolling pulse number or heavy and count.
Method for the treatment of: eliminating fire and detoxication, clearing away heat and cooling blood.
5, damp and hot folder stasis of blood type
Card is shown in: erythra recurrent exerbation, or forms elephatiasis person, and have heating during companion, lassitude and weak, limbs are heavy, indigestion and loss of appetite.Body of the tongue is dim red, or has ecchymosis, yellowish fur, soft and rapid pulse or puckery.
Method for the treatment of: clearing away heat-damp and promoting diuresis, disperse blood stasis and dredge collateral.
Summary of the invention
The technical problem to be solved in the present invention is that exploitation a kind ofly treats Chinese medicine preparation of erysipelas Be very effective and preparation method thereof, for solving this technical problem, the technical scheme that inventor takes is, in tcm clinical practice experience for many years and the basis to the research of erysipelas, meticulous compatibility prescription, by the inspection of clinical practice prescription groped repeatedly and adjust, the Chinese prescription that final acquisition one is brand-new and preparation technology supporting with it, thus obtained Chinese medicine preparation shows very significant therapeutic effect to erysipelas.
Technical scheme of the present invention is, treat a Chinese medicine preparation for erysipelas, its Chinese prescription is expressed as with weight portion: Flos Lonicerae 11-40 part, Radix Paeoniae Rubra 7-27 part, Fructus Forsythiae 7-28 part, Radix Sophorae Flavescentis 10-32 part, Radix Rehmanniae Preparata 12-39 part, Cornu Cervi Degelatinatum 10-32 part, Cortex Cinnamomi 8-21 part, Semen Sinapis Albae 6-19 part, Radix Scrophulariae 9-33 part, Cortex Moutan 8-25 part, Fructus Liquidambaris 6-19 part, Herba Violae 11-33 part, Radix Achyranthis Bidentatae 6-18 part, Rhizoma Alismatis 5-17 part, Cortex Phellodendri 5-19 part, Radix Bupleuri 7-20 part, Radix Gentianae 6-19 part, Semen Coicis 8-21 part, Flos Chrysanthemi Indici 9-23 part, Flos Carthami 4-12 part, Radix Glycyrrhizae 6-13 part.
The prescription proportioning with outstanding representation summing up out in the R&D process of Chinese medicine preparation is (with parts by weight):
Proportioning 1: Flos Lonicerae 25 parts, Radix Paeoniae Rubra 17 parts, Fructus Forsythiae 17 parts, Radix Sophorae Flavescentis 20 parts, 24 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 21 parts, Cortex Cinnamomi 14 parts, Semen Sinapis Albae 12 parts, Radix Scrophulariae 20 parts, Cortex Moutan 16 parts, Fructus Liquidambaris 12 parts, Herba Violae 22 parts, Radix Achyranthis Bidentatae 12 parts, Rhizoma Alismatis 11 parts, Cortex Phellodendri 12 parts, Radix Bupleuri 13 parts, Radix Gentianae 12 parts, Semen Coicis 14 parts, Flos Chrysanthemi Indici 15 parts, 8 parts, Flos Carthami, 9 parts, Radix Glycyrrhizae.
Proportioning 2: Flos Lonicerae 20 parts, Radix Paeoniae Rubra 15 parts, Fructus Forsythiae 15 parts, Radix Sophorae Flavescentis 25 parts, 25 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 25 parts, Cortex Cinnamomi 18 parts, Semen Sinapis Albae 14 parts, Radix Scrophulariae 22 parts, Cortex Moutan 20 parts, Fructus Liquidambaris 14 parts, Herba Violae 20 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Alismatis 10 parts, Cortex Phellodendri 10 parts, Radix Bupleuri 12 parts, Radix Gentianae 12 parts, Semen Coicis 10 parts, Flos Chrysanthemi Indici 13 parts, 6 parts, Flos Carthami, 10 parts, Radix Glycyrrhizae.
The preparation method above-mentioned Chinese prescription being made preparation is following steps:
Step 1, accurately take ingredients respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of the 3-6 of 55-85 DEG C times weight, at 80-85 DEG C of backflow defat 1-4h, medicinal residues are with the alcohol reflux 3 times of the 90-96% of 3-8 times of weight, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 4-12 times of volatile oil weight, add the aqueous solution after the distillation of 1-5 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 50-70 minute, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 60-100 mesh sieve, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 4-16 times weight, be 320-380W at power, temperature is microwave extraction twice under 60-75 DEG C of condition, each 20-50 minute, the aqueous solution after microwave is filtered, and it is the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 65-75 DEG C of condition, obtains dry extract, pulverize, cross 70-100 mesh sieve, be raw material powder b, for subsequent use;
Step 6, Cornu Cervi Degelatinatum to be pulverized, porphyrize, cross 70-100 mesh sieve, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, by raw material of Chinese medicine powder add adjuvant, utilize modern general Chinese medicine preparation technology, make the finished dosage forms required for modern clinic, as dosage forms such as decoction, pill (honeyed pill, the watered pill, paste pill, wax pill, concentrated pill), powder, sublimed preparation, medicated wine, syrup, extractum, lozenge, distillate medicinal water, colloid, medicinal tea, nail agent, stick, paste, cake agent, oil preparation, tablet, electuary, bagged steeping drug, capsule, drop pill, granule, mixture, tinctures.
The source of Chinese medicine preparation raw materials of the present invention, character Characteristic:
Flos Lonicerae: the flower that this product is caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis or band are just opened.Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, wind-heat dissipating.
Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Fructus Forsythiae: this product is the dry fruit of Oleaceae plants Fructus Forsythiae.Bitter in the mouth, cold nature; Return lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis.Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae.Sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fills out marrow.
Cornu Cervi Degelatinatum: this product is that Cornu Cervi removes photoresist the hornblock (boil Colla cornus cervi remaining bone slag) of matter.Salty in the mouth, warm in nature; Return liver, kidney channel; Warming the kidney to activate YANG, astringing to arrest bleeding.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi.Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Semen Sinapis Albae: be the seed of crucifer Caulis et Folium Sinapis albee.Acrid in the mouth, warm in nature; Enter lung, stomach warp; Promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel; Removing heat from blood YIN nourishing, eliminating fire and detoxication.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony.Bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Fructus Liquidambaris: this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum.Bitter in the mouth, property is put down; Return liver, kidney channel; Dispelling, collateral-activating, diuretic stimulates the menstrual flow.
Herba Violae: this product is the dry herb of Violaceae Chinese violet.Bitter in the mouth, pungent, cold in nature; GUIXIN, Liver Channel; Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Bitter in the mouth, acid, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; Diuresis, clearing away damp-heat.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.
Radix Bupleuri: this product is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature; Return liver, gallbladder meridian; Reconciling superficies and interior, soothing the liver, yang invigorating.
Radix Gentianae: this product is the dry root and rhizome of gentianaceae plant Gentiana manshurica, Radix Gentianae, G. triflora or Gentiana rigescens Franch.Bitter in the mouth, cold in nature; Return liver, gallbladder meridian; Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.
Semen Coicis: this product is the dry mature kernal of grass Semen Coicis.Sweet in the mouth, light, cool in nature; Return spleen, stomach, lung meridian; Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.
Flos Chrysanthemi Indici: this product is the dry capitulum of feverfew Herba Dendranthematis indici.Bitter in the mouth, pungent, cold nature; Return liver, heart channel; Heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.
Flos Carthami: call red indigo plant flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium.Acrid in the mouth, warm in nature; Enter the heart, Liver Channel; Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of the Chinese prescription of Chinese medicine preparation of the present invention separates:
This Chinese prescription is with Flos Lonicerae, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum, Herba Violae, Radix Scrophulariae, Radix Sophorae Flavescentis for monarch drug, the detumescence of heat-clearing and toxic substances removing, nourishing YIN and supplementing blood, astringing to arrest bleeding, removing heat from blood, eliminating fire and detoxication; With Radix Paeoniae Rubra, Fructus Forsythiae, Cortex Moutan, Flos Chrysanthemi Indici, Cortex Cinnamomi, Semen Coicis for ministerial drug, eliminating stasis to stop pain, dispersing swelling and dissipating binds, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, clearing away heat and discharging pus; With Semen Sinapis Albae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Radix Bupleuri, Radix Gentianae for adjuvant drug, soothing the liver yang invigorating, heat clearing and damp drying; With Fructus Liquidambaris, Rhizoma Alismatis, Flos Carthami for making medicine, diuretic stimulates the menstrual flow, promoting blood circulation to restore menstrual flow; With all property of medicine matter of Radix Glycyrrhizae mediation monarch, make that all medicines cooperatively interact, synergism thus reach heat-clearing and toxic substances removing, removing heat from blood detumescence, heat clearing and damp drying, promoting blood circulation to restore menstrual flow, clearing away heat and discharging pus, removing obstruction in the collateral to relieve pain, pathogenic fire purging except effects such as steaming, eliminating blood stasis and inducing menstruation, have very significant curative effect to erysipelas, its therapeutical effect will be proved in test hereafter.
Compared with prior art, Chinese medicine preparation of the present invention has following technical advantage in treatment erysipelas:
1, good effect, cure rate high, more after do not recur, have no side effect;
2, Chinese medicine preparation be convenient for carrying take, efficacy stability, simple process be easy, therefore, be suitable for large application scope, social value is huge.
Therefore, the present invention's also application of claimed above-mentioned Chinese medicine preparation in the medicine of preparation treatment erysipelas.
Detailed description of the invention
In order to prove the feasibility of Chinese prescription scope of the present invention and preparation method; and provide medicine for follow-up test; inventor have chosen 5 groups of representational prescription proportionings especially and utilizes the optimal parameter of preparation method of the present invention to carry out the production of electuary; these 5 groups representational prescription proportionings are respectively arbitrary value and optimum ratio in the boundary value of prescription scope, scope, and protection scope of the present invention includes but are not limited to this few assembly ratio.
Embodiment 1
Step 1, accurately take Flos Lonicerae 1100g, Radix Paeoniae Rubra 700g, Fructus Forsythiae 700g, Radix Sophorae Flavescentis 1000g, Radix Rehmanniae Preparata 1200g, Cornu Cervi Degelatinatum 1000g, Cortex Cinnamomi 800g, Semen Sinapis Albae 600g, Radix Scrophulariae 900g, Cortex Moutan 800g, Fructus Liquidambaris 600g, Herba Violae 1100g, Radix Achyranthis Bidentatae 600g, Rhizoma Alismatis 500g, Cortex Phellodendri 500g, Radix Bupleuri 700g, Radix Gentianae 600g, Semen Coicis 800g, Flos Chrysanthemi Indici 900g, Flos Carthami 400g, Radix Glycyrrhizae 600g respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of 5 times of weight of 70 DEG C, at 80 DEG C of backflow defat 2h, medicinal residues with 90% of 4 times of weight alcohol reflux 3 times, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 8 times of volatile oil weight, add the aqueous solution after the distillation of 3 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 60 minutes, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 80 mesh sieves, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 12 times of weight, be 340W at power, temperature is microwave extraction twice under 65 DEG C of conditions, each 40 minutes, the aqueous solution after microwave is filtered, and it was the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 75 DEG C of conditions, obtains dry extract, pulverize, cross 100 mesh sieves, be raw material powder b, for subsequent use;
Step 6, by Cornu Cervi Degelatinatum pulverize, porphyrize, cross 100 mesh sieves, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make electuary, 0.507g crude drug/g electuary.
Embodiment 2
Step 1, accurately take Flos Lonicerae 4000g, Radix Paeoniae Rubra 2700g, Fructus Forsythiae 2800g, Radix Sophorae Flavescentis 3200g, Radix Rehmanniae Preparata 3900g, Cornu Cervi Degelatinatum 3200g, Cortex Cinnamomi 2100g, Semen Sinapis Albae 1900g, Radix Scrophulariae 3300g, Cortex Moutan 2500g, Fructus Liquidambaris 1900g, Herba Violae 3300g, Radix Achyranthis Bidentatae 1800g, Rhizoma Alismatis 1700g, Cortex Phellodendri 1900g, Radix Bupleuri 2000g, Radix Gentianae 1900g, Semen Coicis 2100g, Flos Chrysanthemi Indici 2300g, Flos Carthami 1200g, Radix Glycyrrhizae 1300g respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of 5 times of weight of 70 DEG C, at 80 DEG C of backflow defat 2h, medicinal residues with 90% of 4 times of weight alcohol reflux 3 times, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 8 times of volatile oil weight, add the aqueous solution after the distillation of 3 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 60 minutes, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 80 mesh sieves, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 12 times of weight, be 340W at power, temperature is microwave extraction twice under 65 DEG C of conditions, each 40 minutes, the aqueous solution after microwave is filtered, and it was the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 75 DEG C of conditions, obtains dry extract, pulverize, cross 100 mesh sieves, be raw material powder b, for subsequent use;
Step 6, by Cornu Cervi Degelatinatum pulverize, porphyrize, cross 100 mesh sieves, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make electuary, 0.507g crude drug/g electuary.
Embodiment 3
Step 1, accurately take Flos Lonicerae 3800g, Radix Paeoniae Rubra 900g, Fructus Forsythiae 1000g, Radix Sophorae Flavescentis 3000g, Radix Rehmanniae Preparata 1300g, Cornu Cervi Degelatinatum 3100g, Cortex Cinnamomi 1900g, Semen Sinapis Albae 1500g, Radix Scrophulariae 3200g, Cortex Moutan 900g, Fructus Liquidambaris 1800g, Herba Violae 1200g, Radix Achyranthis Bidentatae 1700g, Rhizoma Alismatis 600g, Cortex Phellodendri 1800g, Radix Bupleuri 800g, Radix Gentianae 1800g, Semen Coicis 900g, Flos Chrysanthemi Indici 2200g, Flos Carthami 500g, Radix Glycyrrhizae 1200g respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of 5 times of weight of 70 DEG C, at 80 DEG C of backflow defat 2h, medicinal residues with 90% of 4 times of weight alcohol reflux 3 times, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 8 times of volatile oil weight, add the aqueous solution after the distillation of 3 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 60 minutes, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 80 mesh sieves, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 12 times of weight, be 340W at power, temperature is microwave extraction twice under 65 DEG C of conditions, each 40 minutes, the aqueous solution after microwave is filtered, and it was the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 75 DEG C of conditions, obtains dry extract, pulverize, cross 100 mesh sieves, be raw material powder b, for subsequent use;
Step 6, by Cornu Cervi Degelatinatum pulverize, porphyrize, cross 100 mesh sieves, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make electuary, 0.507g crude drug/g electuary.
Embodiment 4
Step 1, accurately take Flos Lonicerae 2500g, Radix Paeoniae Rubra 1700g, Fructus Forsythiae 1700g, Radix Sophorae Flavescentis 2000g, Radix Rehmanniae Preparata 2400g, Cornu Cervi Degelatinatum 2100g, Cortex Cinnamomi 1400g, Semen Sinapis Albae 1200g, Radix Scrophulariae 2000g, Cortex Moutan 1600g, Fructus Liquidambaris 1200g, Herba Violae 2200g, Radix Achyranthis Bidentatae 1200g, Rhizoma Alismatis 1100g, Cortex Phellodendri 1200g, Radix Bupleuri 1300g, Radix Gentianae 1200g, Semen Coicis 1400g, Flos Chrysanthemi Indici 1500g, Flos Carthami 800g, Radix Glycyrrhizae 900g respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of 5 times of weight of 70 DEG C, at 80 DEG C of backflow defat 2h, medicinal residues with 90% of 4 times of weight alcohol reflux 3 times, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 8 times of volatile oil weight, add the aqueous solution after the distillation of 3 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 60 minutes, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 80 mesh sieves, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 12 times of weight, be 340W at power, temperature is microwave extraction twice under 65 DEG C of conditions, each 40 minutes, the aqueous solution after microwave is filtered, and it was the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 75 DEG C of conditions, obtains dry extract, pulverize, cross 100 mesh sieves, be raw material powder b, for subsequent use;
Step 6, by Cornu Cervi Degelatinatum pulverize, porphyrize, cross 100 mesh sieves, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make electuary, 0.507g crude drug/g electuary.
Embodiment 5
Step 1, accurately take Flos Lonicerae 2000g, Radix Paeoniae Rubra 1500g, Fructus Forsythiae 1500g, Radix Sophorae Flavescentis 2500g, Radix Rehmanniae Preparata 2500g, Cornu Cervi Degelatinatum 2500g, Cortex Cinnamomi 1800g, Semen Sinapis Albae 1400g, Radix Scrophulariae 2200g, Cortex Moutan 2000g, Fructus Liquidambaris 1400g, Herba Violae 2000g, Radix Achyranthis Bidentatae 1000g, Rhizoma Alismatis 1000g, Cortex Phellodendri 1000g, Radix Bupleuri 1200g, Radix Gentianae 1200g, Semen Coicis 1000g, Flos Chrysanthemi Indici 1300g, Flos Carthami 600g, Radix Glycyrrhizae 1000g respectively by Chinese prescription proportioning of the present invention;
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of 5 times of weight of 70 DEG C, at 80 DEG C of backflow defat 2h, medicinal residues with 90% of 4 times of weight alcohol reflux 3 times, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 8 times of volatile oil weight, add the aqueous solution after the distillation of 3 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 60 minutes, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 80 mesh sieves, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 12 times of weight, be 340W at power, temperature is microwave extraction twice under 65 DEG C of conditions, each 40 minutes, the aqueous solution after microwave is filtered, and it was the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 75 DEG C of conditions, obtains dry extract, pulverize, cross 100 mesh sieves, be raw material powder b, for subsequent use;
Step 6, by Cornu Cervi Degelatinatum pulverize, porphyrize, cross 100 mesh sieves, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make electuary, 0.507g crude drug/g electuary.
In order to prove the safety of Chinese medicine preparation of the present invention, and for follow-up clinical experiment prepare, inventor has carried out toxicity test to the electuary that embodiment of the present invention 1-5 produces:
The animal toxicity test of Chinese medicine preparation of the present invention
1, acute toxicity test
(1), test medicine: the electuary manufactured by embodiment of the present invention 1-5, adds purified water, is modulated into the magma of desired concn, for subsequent use.
(2), experimental animal: common Kunming mouse, body weight 24g ± 4g, male and female half and half, female mice is all without pregnant.
(3), the magma of mouse stomach instant particles as Chinese medicine preparation of the present invention, when given low reaches 716.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1.5 hours recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
(4), result of the test shows: the maximum dosage-feeding of the electuary manufactured by mouse stomach embodiment 1-5 is 716.5g crude drug/kg/d(LD 50> 716.5g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.38g crude drug/kg/d; By weighing machine, the dosis tolerata of the electuary manufactured by mouse stomach embodiment 1-5 is 1885.5 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
2, long-term toxicity test for animals
(1), test medicine: embodiment of the present invention 1-5 gained instant particles as Chinese medicine, adds purified water, is modulated into the magma of desired concn, for subsequent use.
(2), experimental animal: regular grade SD rat, body weight 226g ± 13g, male and female half and half, female rats is all without pregnant.
(3), method and result:
5 kinds of instant particles as Chinese medicines: be divided into high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose; Experimental mouse is divided into 16 groups at random, and wherein the electuary solution of 15 groups of difference gavages, 5 kinds of three dosage, remains one group of gavage normal saline (20 times of patient's dose); All 16 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
Through long-term feeding, all there is not toxic reaction in 16 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 5 kinds of instant particles as Chinese medicines show without chronic toxicity animal.
By above two toxicity tests, prove that the instant particles as Chinese medicine that embodiment of the present invention 1-5 makes is safe, have no side effect, can be taken by patient.
The pharmacodynamic experiment of Chinese medicine preparation of the present invention
1, to the inhibitory action of PGE2 synthesis in rat inflammation tissue:
Get 218 ± 12g rat 80, male and female are regardless of and are divided into 8 groups at random, the high, medium and low dosage of instant particles as Chinese medicine (40,20,10 times for clinical consumption per day) of the embodiment of the present invention 4, embodiment 5 preparation, amoxicillin and clavulanate potassium (abbreviation Acker) matched group and blank group, often organize 10.Dosage: this product is high, normal, basic is respectively 15.2,7.6,3.8g crude drug/kg; Acker group is 0.00625g/kg; Successive administration 3 days, after last medicine 1 hour, right back sufficient subcutaneous injection 1% carrageenin 0.1ml, cause scorching latter 4 hours, put to death rat, on ankle joint, 0.5cm place cuts swelling foot, peeling, shred, normal saline 5ml soaks 1 hour, soak centrifugal (1500rpm) 10 minutes, Aspirate supernatant 0.1ml, add the KOH-MeOH solution 2.0ml of 0.5mol/L, 50 DEG C of constant temperature isomeries 20 minutes, with methanol dilution to 20.0ml, at wavelength 278nm place, measure its absorbance (A) value with UV-2100 ultraviolet spectrophotometer, result with ± SD represents, t inspection between statistical procedures method employing group, result is as shown in table 1.
Table 1 instant particles as Chinese medicine of the present invention on the impact of PGE2 content in inflammatory tissue ( ± SD, n=10)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group;
Table 1 result shows, and the high, medium and low dosage of instant particles as Chinese medicine of the present invention can suppress the synthesis of PGE2 in rat inflammation tissue respectively to some extent, and high, medium and low dosage has pole significance, very significant and significant difference more respectively with blank group; Point out through statistical procedures: its effect of high dosage intensity is suitable with Acker.
2,0.6%HAC is caused to the analgesic activity of mice pain reaction:
Get 23 ± 3g male and healthy mice 80, be divided into 8 groups at random, the embodiment of the present invention 4, the high, medium and low dosage of embodiment 5 instant particles as Chinese medicine, Acker group and blank group, dosage is the same, all by the volume gastric infusion of 0.25ml/10g body weight, blank group gives isopyknic water gastric infusion, for three days on end, 1 hour lumbar injection 0.6%HAC after mensuration last medicine respectively, 0.1ml/10g Mus is heavy, and the writhing number of times in the incubation period and 15 minutes of writhing response appears in record, by formulae discovery pain suppression ratio (%), result with ± SD represents, t inspection between statistical procedures method employing group, result is as shown in table 2.
Table 2 instant particles as Chinese medicine of the present invention to 0.6%HAC cause mice pain reaction effect ( ± SD, n=10)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with Acker group △p < 0.05.
From table 2 result, the high, medium and low dosage of instant particles as Chinese medicine of the present invention all obviously can suppress the writhing incubation period of mice.The significant difference had in various degree is compared with water matched group; The high, medium and low dosage of instant particles as Chinese medicine of the present invention all obviously can reduce the writhing number of times of mice, compares with blank group the significant difference had in various degree, points out Chinese medicine preparation of the present invention to have good analgesic activity.From pain suppression ratio result: Chinese medicine preparation high dose of the present invention is significantly better than Acker.
3, on the impact of histamine phosphate's itch-threshold value:
Cavia porcellus 40, is divided into 4 groups at random, is the embodiment of the present invention 4 groups, the embodiment of the present invention 5 groups, blank group and metronidazole medicine group.1d before experiment, each group Cavia porcellus right back instep depilation gastric infusion 1 time.Experiment is worked as daily coarse sandpaper and is abraded right back instep depilation place epidermis 1cm 2, then gastric infusion 1 time, after 20min, in scratch depilation, 0.01% histamine phosphate 0.05ml/ Mus is dripped in district, after this, every 3min successively with 0.02,0.03,0.04,0.05% ... the concentration increased progressively drop to Cavia porcellus later lick right back sufficient time histamine's total amount be itch-threshold value, the results are shown in Table 3.
Table 3 instant particles as Chinese medicine of the present invention on Cavia porcellus caused by histamine phosphate itch threshold value impact ( ± SD, n=10)
Note: compare with saline control group, * * P < 0.01, * * * P < 0.001; Compare with metronidazole medicine group, △p < 0.05.
No matter as shown in Table 3, compare with normal saline group, be embodiment of the present invention group, or metronidazole medicine group, and the Cavia porcellus itch-threshold value all caused histamine phosphate reaches extremely significant diversity effect, shows that the two all has good itching-relieving action; Compare with metronidazole medicine group, medicine group of the present invention obviously has raising Cavia porcellus itch-threshold value and also reaches significant diversity effect, and point out medicine of the present invention to have good antipruritic ability, this is very effective therapeutical effect for erysipelas.
4, conclusion: to sum up test known, Chinese medicine preparation of the present invention has good antiinflammatory, analgesia and antipruritic effect, points out Chinese medicine preparation of the present invention can show good therapeutical effect to erysipelas.
The clinical effectiveness test of Chinese medicine preparation of the present invention
Erysipelas patient 272 example participating in voluntarily test is collected in this clinical trial altogether, age 18-57 year, man 122 example, female 150 example.All patients are divided into two groups at random, treat 1 group, treat 2 groups of electuaries (0.507g crude drug/g electuary) of producing of the oral embodiment of the present invention 4, embodiment 5 respectively, every day 3 times, each 15g, 4 hours, interval; Within 1 week, be a course for the treatment of, treat 3 courses for the treatment of continuously.By as follows for therapeutic outcome statistics after treatment terminates:
Treat 1 group: cure 84 examples, account for 61.7%; Effective 49 examples, invalid 3 examples, total effective rate is 97.8%; Treat 2 groups: cure 80 examples, account for 58.8%; Effective 51 examples, invalid 5 examples, total effective rate is 96.3%.
Therapeutic outcome shows, and Chinese medicine preparation treatment erysipelas effect prepared by the present invention is very remarkable, and cure rate is up to 61.7%, and total effective rate is up to 97.8%; Therefore, Chinese medicine preparation prepared by preparation method of the present invention achieves huge technological progress and scientific achievement, and its creativeness should be not out in the cold.

Claims (3)

1. prepare a method for the Chinese medicine preparation for the treatment of erysipelas, it is characterized in that, described preparation method comprises the following steps:
Step 1, weight portion ingredients is taken respectively: Flos Lonicerae 11-40 part by Chinese prescription proportioning, Radix Paeoniae Rubra 7-27 part, Fructus Forsythiae 7-28 part, Radix Sophorae Flavescentis 10-32 part, Radix Rehmanniae Preparata 12-39 part, Cornu Cervi Degelatinatum 10-32 part, Cortex Cinnamomi 8-21 part, Semen Sinapis Albae 6-19 part, Radix Scrophulariae 9-33 part, Cortex Moutan 8-25 part, Fructus Liquidambaris 6-19 part, Herba Violae 11-33 part, Radix Achyranthis Bidentatae 6-18 part, Rhizoma Alismatis 5-17 part, Cortex Phellodendri 5-19 part, Radix Bupleuri 7-20 part, Radix Gentianae 6-19 part, Semen Coicis 8-21 part, Flos Chrysanthemi Indici 9-23 part, Flos Carthami 4-12 part, Radix Glycyrrhizae 6-13 part,
Step 2, Fructus Forsythiae, Cortex Phellodendri, Herba Violae, Radix Sophorae Flavescentis to be pulverized respectively, cross 40 mesh sieves, with the petroleum ether of the 3-6 of 55-85 DEG C times weight, at 80-85 DEG C of backflow defat 1-4h, medicinal residues are with the alcohol reflux 3 times of the 90-96% of 3-8 times of weight, it is the thick paste of 1.55-1.65 that extracting solution is condensed into relative density at 60 DEG C, for subsequent use;
Step 3, Flos Lonicerae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Radix Scrophulariae, Cortex Moutan, Fructus Liquidambaris are used steam distillation respectively, the volatile oil distilled is merged, takes the beta-schardinger dextrin-of 4-12 times of volatile oil weight, add the aqueous solution after the distillation of 1-5 times of beta-schardinger dextrin-weight, grind well, add volatile oil, fully grinding 50-70 minute, become pastel, reduced pressure at room temperature obtains light brown inclusion complex, grinds, and crosses 60-100 mesh sieve, be raw material powder a, for subsequent use;
Step 4, Cortex Cinnamomi, Semen Sinapis Albae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Bupleuri, Radix Gentianae, Semen Coicis, Flos Chrysanthemi Indici, Flos Carthami, Radix Glycyrrhizae to be pulverized respectively, mixing, add the purified water of medical material 4-16 times weight, be 320-380W at power, temperature is microwave extraction twice under 60-75 DEG C of condition, each 20-50 minute, the aqueous solution after microwave is filtered, and it is the concentrated solution of 1.15-1.20 that concentrated filtrate obtains relative density at 60 DEG C;
Step 5, the concentrated solution of step 4 is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 60 DEG C be the thick paste of 1.55-1.65, merges with the thick paste of step 1 gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 65-75 DEG C of condition, obtains dry extract, pulverize, cross 70-100 mesh sieve, be raw material powder b, for subsequent use;
Step 6, Cornu Cervi Degelatinatum to be pulverized, porphyrize, cross 70-100 mesh sieve, be raw material powder c, for subsequent use;
Step 7, by raw material powder a, raw material powder b and raw material powder c mix homogeneously, be raw material of Chinese medicine powder;
Step 8, raw material of Chinese medicine powder is added adjuvant, utilize modern general Chinese medicine preparation technology, make the finished dosage forms required for modern clinic.
2. the method for the Chinese medicine preparation of preparation treatment erysipelas according to claim 1, it is characterized in that, with parts by weight, the prescription of described Chinese medicine composition is: Flos Lonicerae 25 parts, Radix Paeoniae Rubra 17 parts, Fructus Forsythiae 17 parts, Radix Sophorae Flavescentis 20 parts, 24 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 21 parts, Cortex Cinnamomi 14 parts, Semen Sinapis Albae 12 parts, Radix Scrophulariae 20 parts, Cortex Moutan 16 parts, Fructus Liquidambaris 12 parts, Herba Violae 22 parts, Radix Achyranthis Bidentatae 12 parts, Rhizoma Alismatis 11 parts, Cortex Phellodendri 12 parts, Radix Bupleuri 13 parts, Radix Gentianae 12 parts, Semen Coicis 14 parts, Flos Chrysanthemi Indici 15 parts, 8 parts, Flos Carthami, 9 parts, Radix Glycyrrhizae.
3. the method for the Chinese medicine preparation of preparation treatment erysipelas according to claim 1, it is characterized in that, described Chinese medicine preparation is prepared from by the Chinese crude drug of following weight portion: Flos Lonicerae 20 parts, Radix Paeoniae Rubra 15 parts, Fructus Forsythiae 15 parts, Radix Sophorae Flavescentis 25 parts, 25 parts, Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum 25 parts, Cortex Cinnamomi 18 parts, Semen Sinapis Albae 14 parts, Radix Scrophulariae 22 parts, Cortex Moutan 20 parts, Fructus Liquidambaris 14 parts, Herba Violae 20 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Alismatis 10 parts, Cortex Phellodendri 10 parts, Radix Bupleuri 12 parts, Radix Gentianae 12 parts, Semen Coicis 10 parts, Flos Chrysanthemi Indici 13 parts, 6 parts, Flos Carthami, 10 parts, Radix Glycyrrhizae.
CN201510981926.8A 2015-12-24 2015-12-24 Method for preparing Chinese herbal preparation for treating erysipelas Withdrawn CN105412704A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101095779A (en) * 2007-07-05 2008-01-02 北京艺信堂医药研究所 Chinese patent drug for treating diabetes erysipelas
CN103251758B (en) * 2013-06-06 2014-11-19 刘建飞 Traditional Chinese medicine preparation for treating erysipelas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101095779A (en) * 2007-07-05 2008-01-02 北京艺信堂医药研究所 Chinese patent drug for treating diabetes erysipelas
CN103251758B (en) * 2013-06-06 2014-11-19 刘建飞 Traditional Chinese medicine preparation for treating erysipelas

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