CN105395676B

CN105395676B - A kind of compound medicament composition for treating animal mycotoxicosis

Info

Publication number: CN105395676B
Application number: CN201510711852.6A
Authority: CN
Inventors: 熊小伟
Original assignee: Jiangxi Liuhe Biotechnology Co Ld
Current assignee: Jiangxi Liuhe Biotechnology Co Ld
Priority date: 2015-10-28
Filing date: 2015-10-28
Publication date: 2019-11-08
Anticipated expiration: 2035-10-28
Also published as: CN105395676A

Abstract

The present invention relates to a kind of compound medicament compositions for treating animal mycotoxicosis, containing a effective amount of plant extracts and it is a effective amount of have take off the substance of mould effect, wherein the plant extracts is that liver kidney is metabolized and the plant extracts of protection liver cell effect is selected from: Schisandra chinens P.E with promoting, siberian Ginseng P.E, licorice, Astragalus Root P.E, extract of Zhuling, tuckahoe extracts, Alisma extract, Herba Plantaginis extract, Herba Lysimachiae extract, lobelia chinensis extract, it is described that there is the substance for taking off mould effect to be selected from: aluminosilicate, montmorillonite, zeolite, bentonite, it is hydrated sodium calcium aluminosilicate, active carbon, yeast cell wall, micronized fiber element, lactic acid bacteria, bioconversion agent.

Description

A kind of compound medicament composition for treating animal mycotoxicosis

Technical field

The present invention relates to a kind of for preventing and treating the compound medicament composition of animal mycotoxin, active constituent by Plant extracts and with the material composition for taking off mould effect.

Background technique

The corn sample for having 88%, 84%, 77% and 60% is shown to the investigation of the mixed feed and feedstuff of China Contain T-2 toxin, aflatoxin, fumarubicin and Ochratoxin A respectively.It is red that all corn samples all contain corn Mould ketenes and vomitoxin, 90% or more mixed fodder sample all contain main mycotoxin in above 6.

Conspicuous aspertoxin: acute conspicuous aspertoxin poisoning is characterized in nephrosis, enteritis and immunosupress, and to pig reproductive ability It can have an impact, be mainly manifested in the maturation for delaying spermatoblast, and lead to initial stage locomitivity decrease and the longevity of sperm Life shortens.Influence to poultry is to significantly inhibit the feeding, growth and feather growth of poultry, leads to egg production and feed conversion rate Decline, cause hatching rate difference and survival rate of embryo to decline.For the chick production performance hatched also below average level, sexal maturity is general All over delay.Conspicuous aspertoxin causes cell in major lymphatic organs (lymphocyte) to degenerate, reduce, and significantly affects the thin of poultry Born of the same parents' immune level.

Fumarubicin: fumarubicin poisoning can cause the spike death syndrome or food poisoning syndrome of poultry. The symptom of spike death syndrome includes paralysis, neck and four limbs outreach, instability of gait, is short of breath and decline of increasing weight.

Deoxidation melon withers chain mykol (vomitoxin): vomitoxin is one in the single-ended spore moldin of the most common Fusarium Kind.This family's toxin usually causes food refusal, vomiting and injury of gastrointestinal tract to pig.Since vomitoxin affects gastrointestinal tract, cause The absorption of nutriment declines, slow growth, and can cause inflammation and inhibit immune.The pig of vomitoxin poisoning is also embodied by Slight nephrosis, atrophy of thyroid gland, stomach lining hyperplasia and the serial of other blood parameters change.

Zearalenone: zearalenone is a kind of metabolite of Fusariumsp, has estrogenic characteristics.Boar connects Foreskin increases after touching zearalenone, mammary gland enlargement.Its young and middle-aged boar is more sensitive than adult male pig, shows as sexual desire drop Low, testis becomes smaller.Influence to sow pig, pregnant sow and lactating sow shows as red and swollen vaginal orifice and rectum and vagina is de- It hangs down, while having significantly damages effect to the reproductive performance of sow.

T-2 toxin: the mutation of T-2 toxin energy modificator gene and chromosome damage.Pig is most sensitive to the toxin.It shows to refuse Food, vomiting, depilation and tissue bleeding, brood sow then show as rate of fertilization reduction, and litter size is reduced, weak young and miscarriage.

Aflatoxin: aflatoxin has wide influence to the metabolism of poultry, it can make a variety of important digestion form sediment The enzymatic activity decline of powder, protein, fat and nucleic acid.In addition aflatoxin turns serum glutamic pyruvic transminase (SGPT), millet straw The activity index for moving enzyme (SGOT) and gamma-glutamic acid transferase (GGT) increases, and liver is prompted to be damaged.Broiler chicken aspergillus flavus poison Element is poisoned, and the content of gross protein, cholesterol and blood urea nitrogen (BUN) is reduced in blood.Aflatoxin can make poultry growth by Resistance, feed conversion rate decline, the death rate increases, egg production is reduced, leg is sick and ketoboidies pollution.To environmental stress and pathogenic microorganism Resistance decline.Generally all there is fatty liver, hepatonecrosis and gallbladder in histopathological examination discovery, poultry aflatoxicosis Pipe hyperplasia.

In conclusion mycotoxin can cause liver kidney impaired, liver kidney metabolic detoxification miopragia is caused, causes toxin in body Interior further accumulation, causes the decline of animal immunizing power；Easily bacterial infection and viral disease, such as circovirus infection, indigo plant Otopathy, swine fever, virus diarrhea etc. simultaneously and then cause such as hyperpyrexia disease secondary infection, mixed infection, cross-infection；It eventually leads to The growth retardation of animal is even dead.In addition the mycotoxin of steroids causes the breeding of animal to decline.

Influence of the mycotoxin to animal is solved at present mainly to prevent by the suction-operated in gastrointestinal tract.In the market Type used mainly have an adsorbent class: aluminosilicate, montmorillonite, zeolite, bentonite, hydration sodium calcium aluminosilicate, activity The strains classes, polymer such as charcoal, yeast cell wall, micronized fiber element, lactic acid bacteria；Bioconversion agent: bacterium, fungi, yeast, enzyme Deng.Above-mentioned to take off mould dose be essentially all the active effect in gastrointestinal tract, for feed before can absorbing after digestion and digestion The absorption of middle mycotoxin, but any one takes off the mould dose of mycotoxin that all cannot fully and completely remove all kinds, and The mycotoxin not removed will be assembled in liver kidney.If the toxin in liver kidney cannot be metabolized as early as possible, toxin buildup is arrived It will lead to the immunity degradation of animal to a certain degree, it is easy to infect various bacteriums, virus, the growth of animal is then caused to subtract Slow, part impaired mechanical is even dead, brings great economic loss to aquaculture.

Summary of the invention

Based on mechanism and reason that the above mycotoxin causes a disease, the drug component of the invention from promote the metabolism of the liver nephrotoxin, Protection liver cell and toxin adsorb coefficient principle and set out, and reduce mycotoxin residence time in animal body, mention simultaneously High animal autoimmunity reduces harm of the mycotoxin to animal to greatest extent.

The present invention provides a kind of compound medicament composition for treating animal mycotoxicosis, mentions containing a effective amount of plant Object is taken and a effective amount of with the substance for taking off mould effect, wherein the plant extracts is with the metabolism of promotion liver kidney and protection liver The plant extracts of cytosis.The plant extracts is selected from: Schisandra chinens P.E, siberian Ginseng P.E, licorice, Astragalus Root P.E, extract of Zhuling, tuckahoe extracts, Alisma extract, Herba Plantaginis extract, Herba Lysimachiae extract, lobelia chinensis Extract.

It is described that there is the substance for taking off mould effect to be selected from: aluminosilicate, montmorillonite, zeolite, bentonite, hydration sodium calcium aluminium silicon acid Salt, active carbon, yeast cell wall, micronized fiber element, lactic acid bacteria, bioconversion agent.The bioconversion agent is selected from: bacterium, Fungi, yeast, enzyme, functional polymer.

Also contain pharmaceutical carrier in described pharmaceutical composition.The pharmaceutical carrier include diluent such as: inorganic salts are selected from Calcium carbonate, calcium bicarbonate, calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, calcium dihydrogen phosphate etc. or solid acids are selected from citric acid, rich horse Acid, malic acid, tartaric acid, glycine and maize cob meal, wheat bran.

The pharmaceutical carrier includes sweetener, is selected from: stevioside, Sucralose, honey element, acesulfame potassium, saccharin sodium, sugarcane Sugar, fructose, starch sugar, sugar alcohol and Fructooligosaccharides, isomaltoketose, arrowroot glucin etc..Preferably Sucralose.

Preferably, described pharmaceutical composition forms as follows:

Schisandra chinens P.E 40-60g,

Tuckahoe extracts 70-90g,

Montmorillonite 500-700g,

Remaining is pharmaceutical carrier；

Or,

Schisandra chinens P.E 40-60g,

Tuckahoe extracts 70-90g,

Remaining is pharmaceutical carrier；

Or,

Herba Lysimachiae extract 20-40g,

Siberian Ginseng P.E 50-70g,

Bacillus subtilis 4000-6000 (hundred million),

Remaining is pharmaceutical carrier；

Or

Schisandra chinens P.E 40-60g,

Licorice 90-110g,

Brewer's yeast wall extract 40-60g,

Remaining is pharmaceutical carrier；

Or

Astragalus Root P.E 50-70g,

Lobelia chinensis extract 90-110g,

Bentonite 400-600g,

Remaining is pharmaceutical carrier；

Or

Astragalus Root P.E 50-70g,

Alisma extract 290-310g,

Lactic acid bacteria 290-310g,

Remaining is pharmaceutical carrier；

Or

Siberian Ginseng P.E 50-70g

Extract of Zhuling 110-130g

Lactic acid bacteria 290-310g

Remaining is pharmaceutical carrier；

Or

Siberian Ginseng P.E 50-70g

Licorice 90-110g

The mould solution agent 290-310g of mycotoxin

Remaining is pharmaceutical carrier；

Or

Herba Plantaginis extract 50-70g

Licorice 90-110g

It is hydrated sodium calcium aluminosilicate 440-460g

Remaining is pharmaceutical carrier；

Particularly preferred pharmaceutical composition forms as follows:

Schisandra chinens P.E 50g,

Tuckahoe extracts 80g,

Montmorillonite 600g,

Remaining is pharmaceutical carrier；

Or,

Schisandra chinens P.E 50g,

Tuckahoe extracts 80g,

Remaining is pharmaceutical carrier；

Or,

Herba Lysimachiae extract 30g,

Siberian Ginseng P.E 60g,

Bacillus subtilis 5000 (hundred million),

Remaining is pharmaceutical carrier；

Or

Schisandra chinens P.E 50g,

Licorice 100g,

Brewer's yeast wall extract 50g,

Remaining is pharmaceutical carrier；

Or

Astragalus Root P.E 60g,

Lobelia chinensis extract 100g,

Bentonite 500g,

Remaining is pharmaceutical carrier；

Or

Astragalus Root P.E 60g,

Alisma extract 300g,

Lactic acid bacteria 300g,

Remaining is pharmaceutical carrier；

Or

Siberian Ginseng P.E 60g

Extract of Zhuling 120g

Lactic acid bacteria 300g

Remaining is pharmaceutical carrier；

Or

Siberian Ginseng P.E 60g

Licorice 100g

The mould solution agent 300g of mycotoxin

Remaining is pharmaceutical carrier；

Or

Herba Plantaginis extract 60g

Licorice 100g

It is hydrated sodium calcium aluminosilicate 450g

Remaining is pharmaceutical carrier.

Most preferred pharmaceutical composition forms as follows:

Contain in 1000g:

Plant extracts of the present invention can be obtained commercially, can also be obtained according to prior art preparation, Such as vegetable drug is added water to cook, obtains medicinal extract, as extract.Extract can be 5-15:1's, preferably 10:1's, i.e., The vegetable drug of 10 parts of weight extracts to obtain the medicinal extract of 1 part of weight, and the medicinal extract is preferably dry extract.

Beneficial effects of the present invention are further illustrated below by way of experimental data:

Field trial one:

Certain pig farm of in July, 2012 Hebei China: basic sow 500, is first farrowing sow.3000 bull of growing and fattening pigs.

Incidence: being mainly manifested in weight on 70 jin or more of hog, shows vulva exception enlargement outside, rubescent, With 30% incidence of diarrhea, frequent occurrence, insemination of sows rate reduces rectal prolapse phenomenon, feed intake decline, slow growth, when morbidity Between in or so January.Disease Diagnosis of Veterinary is mycotoxicosis.Mycotoxin is carried out by corn and with the complete feed that corn is worked good Detection, zeranol and vomitoxin severely exceed in corn as the result is shown, content respectively reached 1.56mg/kg and 3.12mg/kg。

Therapeutic scheme was as follows at that time: the substantially similar sick pig of symptom is picked out 200, is divided into two groups, every group 100, Again the corn for selecting mycotoxin contamination lighter complete feed is formulated, and control group and examination will be added respectively in feed It tests group and takes off mould dose of composition component, feed per ton adds 1kg respectively.

Control group ingredient:

Contain in 1000g compound component:

High-purity montmorillonite: 600g

Sucralose: 50g

Diluent is extremely: 1000g

Test group ingredient (component in example one):

Contain in 1000g compound component:

Usage and dosage is shown in Table one.

Table one

Experimental result is shown in Table two

Conclusion: from experimental result it can be seen that after eating by the feed of mycotoxin contamination, heat-clearing is added in feed Removing toxic substances, inducing diuresis for removing edema promote the plant extracts of liver kidney metabolism, can promote the metabolism of mycotoxin, reduce toxin in animal Intracorporal aggregation promotes rehabilitation after zoosis.

Field trial two

Shandong in May, 2012 pig farm, 5000 bull growing and fattening pigs, 40 kilograms of weight average, swinery is edible by mould poison After the complete diet pellet of element pollution, there is loss of appetite, lassitude is fallen ill the later period, and swinery infects haemophilus parasuis, and appetite is close Abolish, liver renal failure, ascites are serious.60 that most serious is selected from sick pig group, are divided into two groups, every group 30, one group is Control group, one group is test group.With drinking water administration.

Therapeutic scheme is as follows:

Usage and dosage is shown in Table three.

Table three

Experimental result

Experimental result is shown in Table four

Table four

Conclusion: from experimental result as can be seen that washing in a pan swinery to the dead of the secondary infection as caused by mycotoxicosis, with Control group compares, and has significant difference and excellent added with the therapeutic and protective effects of the experimental group of Schisandra chinens P.E and tuckahoe extracts Gesture.

Specific embodiment

The present invention is further illustrated by the following examples.

The medicine components of the invention are exemplified below but are not limited to enumerate:

Contain in 1. 1000g compound component of example:

Contain in 2. 1000g compound component of example:

Contain in 3. 1000g compound component of example:

Contain in 4. 1000g compound component of example:

Contain in 5. 1000g compound component of example:

Contain in 6. 1000g compound component of example:

Contain in 7. 1000g compound component of example:

Contain in 8. 1000g compound component of example:

Contain in 9. 1000g compound component of example:

。

Claims

1. a kind of compound medicament composition for treating animal mycotoxicosis, which is characterized in that described pharmaceutical composition each group Divide weight proportion as follows:

Schisandra chinens P.E 40-60g,

Tuckahoe extracts 70-90g,

Montmorillonite 500-700g,

Remaining is pharmaceutical carrier.