CN105385056A - Biological bactericidal plastic - Google Patents
Biological bactericidal plastic Download PDFInfo
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- CN105385056A CN105385056A CN201511008566.XA CN201511008566A CN105385056A CN 105385056 A CN105385056 A CN 105385056A CN 201511008566 A CN201511008566 A CN 201511008566A CN 105385056 A CN105385056 A CN 105385056A
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- antibiotic plastics
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- 229920003023 plastic Polymers 0.000 title claims abstract description 51
- 239000004033 plastic Substances 0.000 title claims abstract description 51
- 230000000844 anti-bacterial effect Effects 0.000 title abstract description 17
- 229920000642 polymer Polymers 0.000 claims abstract description 26
- 239000002105 nanoparticle Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000011259 mixed solution Substances 0.000 claims abstract description 8
- 230000003115 biocidal effect Effects 0.000 claims description 28
- 230000004071 biological effect Effects 0.000 claims description 21
- 230000000845 anti-microbial effect Effects 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims description 4
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 4
- 238000001764 infiltration Methods 0.000 claims description 4
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims description 4
- 102000004317 Lyases Human genes 0.000 claims description 3
- 108090000856 Lyases Proteins 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 16
- 230000006378 damage Effects 0.000 abstract description 4
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 description 25
- 239000002131 composite material Substances 0.000 description 15
- 230000000855 fungicidal effect Effects 0.000 description 14
- 239000007788 liquid Substances 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- 239000000725 suspension Substances 0.000 description 11
- 230000000975 bioactive effect Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 239000004800 polyvinyl chloride Substances 0.000 description 10
- 229920000915 polyvinyl chloride Polymers 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 239000004793 Polystyrene Substances 0.000 description 8
- 229920002223 polystyrene Polymers 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 108010064696 N,O-diacetylmuramidase Proteins 0.000 description 6
- 239000002102 nanobead Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 229960000935 dehydrated alcohol Drugs 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 238000001291 vacuum drying Methods 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 102000005936 beta-Galactosidase Human genes 0.000 description 4
- 108010005774 beta-Galactosidase Proteins 0.000 description 4
- 239000003139 biocide Substances 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 238000009533 lab test Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 229920001169 thermoplastic Polymers 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000007720 emulsion polymerization reaction Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- 229960002203 tilactase Drugs 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940089256 fungistat Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 239000012716 precipitator Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
- C08L25/02—Homopolymers or copolymers of hydrocarbons
- C08L25/04—Homopolymers or copolymers of styrene
- C08L25/06—Polystyrene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
- C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L27/04—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C08L27/06—Homopolymers or copolymers of vinyl chloride
Abstract
The invention discloses a biological bactericidal plastic. A preparation method of the biological bactericidal plastic includes the following steps that biologically-active antibacterial molecules are dissolved in water to be prepared into a mixed solution system, polymer nano-particles are added in the system and evenly mixed, then the mixture is subjected to swab-off and placed in a mould to be pressed at room temperature, and the biological bactericidal plastic is obtained. The biological bactericidal plastic has the advantages that the polymer nano-particles serve as a carrier, the natural biologically-active antibacterial molecules are compounded at the room temperature (0-40 DEG C), and then the biological bactericidal plastic is obtained; the plastic is good in bactericidal activity and slow release property and not likely to cause environmental pollution, and does no harm to human health; meanwhile, the preparation method of the biological bactericidal plastic is simple, environmentally friendly and capable of being widely applied to various biological antibacterial molecule systems and various macromolecule systems.
Description
Technical field
The invention belongs to plastic applications, particularly relate to a kind of biological antibiotic plastics.
Background technology
Antibiotic plastic a kind ofly possesses special plastic that is antibacterial or bactericidal property, and plastic matrix and the blended granulation of a certain amount of antiseptic-germicide normally obtain by it, can obtain various mechanicals through the technique such as injection moulding or blowing.In existing antibiotic plastic, conventional fungistat is mainly divided into two large classes at present, and a class is inorganic antiseptic, and another kind of is organic antibacterial agent.But these chemical antiseptic-germicides often easily cause environmental pollution or have certain harm to the health of human body.
Natural bio-antimicrobial agents possesses the advantages such as efficient, harmless and environmental friendliness, and the enhancing along with people's environmental consciousness and the raising to health requirements, natural bio-antimicrobial agents will become the first-selection of following antibiotic plastic.Natural bio-antimicrobial agents is mainly divided into animal class antiseptic-germicide and plant antiseptic-germicide, and animal class antiseptic-germicide mainly comprises chitin, chitosan and some antimicrobial proteins, enzyme; Plant antiseptic-germicide mainly contains the extract of the plants such as juniper, argy wormwood and aloe.But, the antibiotic plastic that at present commercially seldom to see with natural bioactive molecule be effective constituent, this is because the machine-shaping of conventional thermoplastic's plastics is carried out under high temperature (usually more than 100 DEG C), also just require that these antiseptic-germicides can withstand high temperatures and do not decompose sex change, but due to bioactive molecules volatility inactivation in hot environment, be therefore difficult to find a kind of method of universality to produce this antibiotic plastic.
Summary of the invention
Goal of the invention: the object of this invention is to provide one and be compounded with biological activity antimicrobial molecule, and there are the biological antibiotic plastics of good fungicidal activity.
Technical scheme: biological antibiotic plastics of the present invention are obtained by following steps: by soluble in water for biological activity antimicrobial molecule, be mixed with the mixed solution system of 0.1 ~ 10wt%, polymer nano-particle is added in this system, drain after mixing, and put it in mould, suppress 1 ~ 20min under pressure is 100 ~ 250MPa, room temperature condition after, pressure release, the demoulding, i.e. these biological antibiotic plastics obtained, wherein, the mass ratio of polymer nano-particle and biological activity antimicrobial molecule is 5 ~ 1000:1.
Furtherly, biological activity antimicrobial molecule of the present invention preferably can be lyase bacterium, chitosan, antimicrobial peptide or sterilization-infiltration and strengthens albumen, the mixed solution system of preparation preferably can be 0.1 ~ 17wt%, the mass ratio of polymer nano-particle and biological activity antimicrobial molecule is 5 ~ 500:1, the particle diameter of polymer nano-particle is 40 ~ 1500nm, preferably can be 40 ~ 1000nm, preferably can be 40 ~ 500nm further.
According to " going congested " principle, polymer nano-particle is when withstanding pressure, and its macromolecular chain flows, thus can wrapping biological active antimicrobial molecule further, form a kind of relatively uniform appearance structure, preferably, institute's applied pressure is 120 ~ 230MPa, and room temperature is 0 ~ 40 DEG C.
Beneficial effect: compared with prior art, remarkable advantage of the present invention is by taking polymer nano-particle as carrier, (0 ~ 40 DEG C) composite natral biological activity antimicrobial molecule at ambient temperature, thus obtained a kind of novel biological antibiotic plastics, these plastics have good fungicidal activity, slow release characteristic and not easily cause environmental pollution and the advantage such as to be harmful to human health; Meanwhile, its preparation method is simple, environmental protection, can be widely used in various biological antibiotic molecular system and various Polymer Systems.
Accompanying drawing explanation
Fig. 1 is that the polystyrene that preparation method of the present invention and traditional thermoplastic working method obtain contrasts figure with the biological activity of beta-galactosidase enzymes composite plastic;
Fig. 2 is polystyrene-N,O-Diacetylmuramidase composite plastic fungicidal activity graphic representation;
The slow release characteristic graphic representation of Fig. 3 measured by the polystyrene-filtrate of N,O-Diacetylmuramidase composite plastic after a large amount of sterilized water repeatedly washs.
Embodiment
Below in conjunction with accompanying drawing, technical scheme of the present invention is further described.
New bio bactericidal plastic of the present invention is obtained by following steps: by soluble in water for biological activity antimicrobial molecule, be mixed with the mixed solution system of 0.1 ~ 10wt%, polymer nano-particle is added in this system, drain after mixing, and put it in mould, and suppress 1 ~ 20min under pressure is 100 ~ 250MPa, room temperature condition after, pressure release, the demoulding, namely wherein, the mass ratio of polymer nano-particle and biological activity antimicrobial molecule is 5 ~ 1000:1 to these biological antibiotic plastics obtained.
Generally when processing biomolecules, through the water of aseptically process, and try not containing too many inorganic salt particle in the inside, in order to avoid destruction biological activity, preferably, the water of employing can be sterile distilled water.Biological activity antimicrobial molecule of the present invention preferably can be lyase bacterium, chitosan, antimicrobial peptide or sterilization-infiltration and strengthens albumen, the mixed solution system of preparation preferably can be 0.1 ~ 7wt%, wherein, the mass ratio of polymer nano-particle and biological activity antimicrobial molecule is 5 ~ 500:1, the particle diameter of polymer nano-particle is 40 ~ 1500nm, preferably can be 40 ~ 1000nm, preferably can be 40 ~ 500nm further, institute's applied pressure is 120 ~ 230MPa, and room temperature is 0 ~ 40 DEG C.
Embodiment 1
Prepared by polystyrene and beta-galactosidase enzymes composite plastic: utilize emulsion polymerization to prepare pipe/polyhenylethylene nano bead 10 grams that particle diameter is 150nm, and after washing 5 times respectively with dehydrated alcohol, distilled water successively, vacuum-drying is for subsequent use.10 milligrams of beta-galactosidase enzymess are dissolved in 10ml sterile distilled water, fully stir, be dissolved to homogeneous system.10 grams of polystyrene spheres are added in system, rapid stirring makes it form uniform suspension liquid, and put into mould after being drained by this suspension liquid and pave, pressing machine is put into through mould, the pressure of 250MPa is applied under 40 DEG C of conditions, and after pressure is kept 20min, pressure release, the demoulding, can obtain polystyrene and beta-galactosidase enzymes composite plastic.
Embodiment 2
Comparison of design is tested, the preparation method under traditional thermoplastic working method and room temperature of the present invention is adopted to prepare polystyrene and β respectively--tilactase matrix material, utilizing β--tilactase can catalytic hydrolysis β-D galactopyranoside (RBG) and generate and have the character of red fluorescence product, whether be maintained in the activity of checking enzyme, test-results as shown in Figure 1, wherein, ordinate zou is the fluorescence intensity of enzymic catalytic reaction product, and X-coordinate is the reaction times.
As shown in Figure 1, when matrix material catalytic hydrolysis β-D galactopyranoside (RBG) adopting traditional thermoplastic working method obtained, because the activity of enzyme disappears, reaction cannot be carried out, therefore to remain on a lower numerical value constant always for its fluorescence intensity, and when adopting matrix material catalytic hydrolysis β-D galactopyranoside (RBG) obtained under room temperature condition of the present invention, β--tilactase maintains good activity in the composite, its constantly catalytic hydrolysis β-D galactopyranoside (RBG) generate the product of hyperfluorescenceZeng Yongminggaoyingguang, manifestation is in the drawings that the fluorescence intensity of product increases with the reaction times and constantly raises, finally be tending towards a stationary value.
Embodiment 3
The preparation of polyvinyl chloride and bovine serum albumin (BSA) composite plastic: the polyvinyl chloride nano bead 5 grams utilizing nanoparticle settling process to prepare particle diameter to be about 40nm, after washing 5 times respectively with dehydrated alcohol, distilled water successively, vacuum-drying is for subsequent use.1 gram of bovine serum albumin is dissolved in 10ml sterile distilled water, abundant stirring, be dissolved to homogeneous system, 5 grams of polyvinyl chloride nano beads are added in this system, rapid stirring makes it form uniform suspension liquid, and puts into mould after being drained by this suspension liquid and pave, and puts into pressing machine through mould, the pressure of 100MPa is applied under 0 DEG C of condition, and after pressure is kept 1min, pressure release, the demoulding, can obtain the composite plastic of polyvinyl chloride and bovine serum albumin.
Embodiment 4
The preparation of polystyrene-N,O-Diacetylmuramidase composite plastic: adopt emulsion polymerization to prepare the pipe/polyhenylethylene nano bead 350g that particle diameter is 600nm, successively after dehydrated alcohol and sterile distilled water wash 5 times respectively, vacuum-drying is for subsequent use.0.7g chitosan is dissolved in 10ml sterile distilled water, be mixed with the mixing solutions of 7wt%, abundant stirring, be dissolved to homogeneous system, 350g polyvinyl chloride bead is added in system, rapid stirring makes it form uniform suspension liquid, and put into mould after being drained by this suspension liquid and pave, pressing machine is put into through mould, the pressure of 220MPa is applied under 30 DEG C of conditions, and after pressure is kept 20min, pressure release, the demoulding, the sterilization polystyrene plastic being compounded with biological activity antimicrobial molecule N,O-Diacetylmuramidase can be obtained, its fungicidal activity curve as shown in Figure 2, from the curve of Fig. 2, when micrococcus lysodeikticus suspension liquid put into by composite plastic, bacterium is killed fast, system clarity raises fast, the absorbancy that correspond in figure reduces fast.
By polystyrene-N,O-Diacetylmuramidase matrix material in a large amount of aseptic deionized water after vigorous stirring 10min, 1ml filtrate is gone to carry out the mensuration of sterilization effect, repetitive scrubbing like this 15 times, the slow release characteristic graphic representation recorded as shown in Figure 3, as shown in Figure 3, in the process of a large amount of water washings, in filtrate, lysozyme content progressively reduces, but to this stage of 10 ~ 15 times, content is but substantially constant, can illustrate thus, composite plastic prepared by present method has slow release characteristic, and in certain scope, maintain comparatively uniform rate of release.
Embodiment 5
The preparation of polyvinyl chloride and N,O-Diacetylmuramidase composite plastic: adopt the nanoparticle precipitator method to prepare polyvinyl chloride nano bead 5g that particle diameter is 40nm, successively after dehydrated alcohol and sterile distilled water wash 5 times respectively, vacuum-drying is for subsequent use.1g N,O-Diacetylmuramidase is dissolved in 10ml water, be mixed with the mixing solutions of 10wt%, abundant stirring, be dissolved to homogeneous system, add in system by 5g polyvinyl chloride bead, rapid stirring makes it form uniform suspension liquid, and put into mould after being drained by this suspension liquid and pave, put into pressing machine through mould, under 0 DEG C of condition, apply the pressure of 100MPa, and after pressure is kept 1min, pressure release, the demoulding, can obtain the sterilization igelite being compounded with biological activity antimicrobial molecule N,O-Diacetylmuramidase.
Embodiment 6
The preparation of polystyrene and Chitosan Composites: adopt emulsion polymerization to prepare pipe/polyhenylethylene nano bead 10g that particle diameter is 1500nm, successively after dehydrated alcohol and sterile distilled water wash 5 times respectively, vacuum-drying is for subsequent use.10mg chitosan is dissolved in 10ml water, be mixed with the mixing solutions of 0.1wt%, abundant stirring, be dissolved to homogeneous system, add in system by 5g polyvinyl chloride bead, rapid stirring makes it form uniform suspension liquid, and put into mould after being drained by this suspension liquid and pave, put into pressing machine through mould, under 40 DEG C of conditions, apply the pressure of 250MPa, and after pressure is kept 20min, pressure release, the demoulding, can obtain the sterilization igelite being compounded with bioactive molecules N,O-Diacetylmuramidase.
Polymer nano-particle, except the polyvinyl chloride adopted in above-described embodiment and polystyrene, adopts other polymer nano-particle can prepare the bactericidal plastic of composite bio-active antimicrobial molecule equally.
Embodiment 7
Design 7 groups of parallel laboratory tests, the mass ratio of polymer and bioactive molecules is respectively 1:1,5:1,10:1,100:1,500:1,1000:1,1100:1, bioactive molecules is bioactive molecules antimicrobial peptide, all the other steps are identical with embodiment 6, and the performance of obtained matrix material is as shown in table 1.
The performance synopsis of the matrix material that the different polymer add-on of table 1 obtains
As shown in Table 1, the fungicidal activity of 2nd ~ 6 groups of matrix materials obtained and slow release characteristic are due to the 1st and the experiment of 7 groups, wherein, be that 10 ~ 500:1 is best with the add-on of polymer and biological activity biocide molecule, this be due to biological activity biocide molecule and high molecular ratio larger time, fungicidal activity is stronger, and when the ratio of the two is excessive, biocide molecule will discharge fast, and cannot slowly-releasing; And when the two ratio more hour, although the activity of the biomolecules kept is strong, obtained matrix material is unstable, and biocide molecule will closely be fettered, and cannot discharge.
Embodiment 8
Design 6 groups of parallel laboratory tests, the mass percent of the mixed solution system of preparation is respectively 0.05wt%, 0.1wt%, 3wt%, 7wt%, 10wt%, 11wt%, biological activity antimicrobial molecule adopts sterilization-infiltration to strengthen albumen, all the other steps are identical with embodiment 6, and the performance of obtained bactericidal plastic is as shown in table 2.
The performance synopsis of the bactericidal plastic that different mass volumetric concentration obtains prepared by table 2
As shown in Table 2, the fungicidal activity of the matrix material that the experiment that the fungicidal activity of 2nd ~ 6 groups of matrix materials obtained is better than the 1st group obtains, slow release characteristic is better than the slow release characteristic of the matrix material that the 6th group of experiment obtains, this be due to the massfraction of mixed system of preparation too little time, the inactivation ratio of bioactive molecules can be caused to increase, and preparation massfraction excessive time, bioactive molecules cannot be adsorbed on polymer equably, thus making the matrix material that obtains uneven, slow release characteristic is poor.
Embodiment 9
Design 6 groups of parallel laboratory tests, the particle diameter of the polymer nano-particle of preparation is respectively 40nm, 100nm, 500nm, 1000nm, 1500nm, 1600nm, and all the other steps are identical with embodiment 6, and the performance of obtained matrix material is as shown in table 3.
The performance synopsis of the matrix material that the high molecular different-grain diameter of table 3 obtains
| Group number | 1 | 2 | 3 | 4 | 5 | 6 |
| Particle diameter/nm | 40 | 100 | 500 | 1000 | 1500 | 1600 |
| Fungicidal activity | By force | By force | Stronger | Medium | Better | Poor |
| Slow release characteristic | Good | Good | Medium | Medium | Better | Poor |
As shown in Table 3, the fungicidal activity of 1st ~ 5 groups of matrix materials obtained and slow release characteristic are better than fungicidal activity and the slow release characteristic of the matrix material that the 6th group of experiment obtains, this is because high molecular particle diameter is larger, the matrix material of preparation is more uneven, and bioactive molecules is wrapped, the poor activity of matrix material, meanwhile, slow release speed also cannot be even.
Embodiment 10
Design 6 groups of parallel laboratory tests, the pressure of setting is respectively 50MPa, 100MPa, 120MPa, 230MPa, 250MPa, 300MPa, and all the other steps are identical with embodiment 6, and the performance of obtained matrix material is as shown in table 4.
The performance synopsis of matrix material obtained under the pressure condition that table 4 is different
| Group number | 1 | 2 | 3 | 4 | 5 | 6 |
| Pressure/MPa | 50 | 100 | 120 | 230 | 250 | 300 |
| Fungicidal activity | Stronger | Stronger | Stronger | Medium | Medium | Poor |
| Slow release characteristic | Poor | Better | Better | Better | Better | Better |
As shown in Table 4, the fungicidal activity of 2nd ~ 5 groups of matrix materials obtained is better than the fungicidal activity of the obtained matrix material of the 6th experiment, slow release characteristic is better than the slow release characteristic of the 1st group of matrix material obtained, this is due to when pressure is excessive, the activity of easy destruction biomolecules, and when pressure is too small, obtained matrix material is unstable, its slow release speed is also unstable.
Claims (9)
1. biological antibiotic plastics, it is characterized in that: these biological antibiotic plastics are obtained by following steps: by soluble in water for biological activity antimicrobial molecule, be mixed with the mixed solution system of 0.1 ~ 10wt%, polymer nano-particle is added in this system, drain after mixing, and put it in mould, suppress 1 ~ 20min under pressure is 100 ~ 250MPa, room temperature condition after, pressure release, the demoulding, i.e. these biological antibiotic plastics obtained, wherein, the mass ratio of polymer nano-particle and biological activity antimicrobial molecule is 5 ~ 1000:1.
2. biological antibiotic plastics according to claim 1, is characterized in that: described biological activity antimicrobial molecule is lyase bacterium, chitosan, antimicrobial peptide or sterilization-infiltration enhancing albumen.
3. biological antibiotic plastics according to claim 1, is characterized in that: the mass percent of described mixed solution system is 0.1 ~ 7wt%.
4. biological antibiotic plastics according to claim 1, is characterized in that: the particle diameter of described polymer nano-particle is 40 ~ 1500nm.
5. biological antibiotic plastics according to claim 4, is characterized in that: the particle diameter of described polymer nano-particle is 40 ~ 1000nm.
6. biological antibiotic plastics according to claim 5, is characterized in that: the particle diameter of described polymer nano-particle is 40 ~ 500nm.
7. biological antibiotic plastics according to claim 1, is characterized in that: the mass ratio of described polymer nano-particle and biological activity antimicrobial molecule is 10 ~ 500:1.
8. biological antibiotic plastics according to claim 1, is characterized in that: described pressure is 120 ~ 230MPa.
9. biological antibiotic plastics according to claim 1, is characterized in that: described room temperature is 0 ~ 40 DEG C.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110451617A (en) * | 2019-07-11 | 2019-11-15 | 石狮市星火铝制品有限公司 | Sterilizing deodoring device and the method sterilized using the sterilizing deodoring device |
| CN111363270A (en) * | 2020-03-31 | 2020-07-03 | 常德集智生物科技有限公司 | Broad-spectrum antiviral bactericidal plastic and application thereof |
| CN111561743A (en) * | 2020-06-01 | 2020-08-21 | 福建优净星环境科技有限公司 | Sterilizing air conditioner indoor unit and sterilizing method adopting same |
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| CN111561743A (en) * | 2020-06-01 | 2020-08-21 | 福建优净星环境科技有限公司 | Sterilizing air conditioner indoor unit and sterilizing method adopting same |
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