CN105379631A - Rat hypertension model preparation device - Google Patents
Rat hypertension model preparation device Download PDFInfo
- Publication number
- CN105379631A CN105379631A CN201510948284.1A CN201510948284A CN105379631A CN 105379631 A CN105379631 A CN 105379631A CN 201510948284 A CN201510948284 A CN 201510948284A CN 105379631 A CN105379631 A CN 105379631A
- Authority
- CN
- China
- Prior art keywords
- rat
- hypertension
- model preparation
- proof box
- hypertension model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010020772 Hypertension Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229910000838 Al alloy Inorganic materials 0.000 claims description 4
- 238000001125 extrusion Methods 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 241000274582 Pycnanthus angolensis Species 0.000 claims description 2
- 239000011087 paperboard Substances 0.000 claims description 2
- 239000005336 safety glass Substances 0.000 claims description 2
- 239000000565 sealant Substances 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 238000011616 hypertension animal model Methods 0.000 abstract description 11
- 230000000638 stimulation Effects 0.000 abstract description 5
- 238000011699 spontaneously hypertensive rat Methods 0.000 abstract description 3
- 241000700159 Rattus Species 0.000 abstract 8
- 238000002955 isolation Methods 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 208000007530 Essential hypertension Diseases 0.000 description 4
- 230000001631 hypertensive effect Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 3
- 206010057615 Endocrine hypertension Diseases 0.000 description 2
- 201000003099 Renovascular Hypertension Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000008700 sympathetic activation Effects 0.000 description 2
- ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 229960003654 desoxycortone Drugs 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The invention relates to a rat hypertension model preparation device and belongs to animal experiment equipment. The rat hypertension model preparation device is composed of a sound isolation box, a rat feed trough and a kettle bayonet. The rat feed trough is arranged in the sound isolation box, and a top cover of the rat feed trough is provided with a downwards concave curved surface; the kettle bayonet is arranged at the low position of the downwards concave curved surface; the upper corner of the inner side of the sound isolation box is provided with a high-frequency sound generator. According to the rat hypertension model preparation device, the hypertension of rats can be raised in a short time through sound stimulation, a stable hypertension animal model is formed, the hypertension is stable, nearly no influence is caused to the external environment, and the rat hypertension model preparation device is consistent with the natural law of spontaneously hypertensive rats.
Description
Technical field
The present invention relates to a kind of rat hypertension model preparation facilities, belong to a kind of zoopery equipment.
Background technology
Hypertension animal model is the important means of research high blood pressure and pharmacotherapy thereof.Current modal hypertension animal model comprises: spontaneously hypertensive rat model; Renovascular hypertension animal model; Neuron specific emelase animal model; Endocrine hypertension animal model; Stress-induced hypertension animal model.Wherein, spontaneously hypertensive rat model is the mutantion line rat cultivated, the spontaneously hypertensive change of this rat is similar to the mankind, its offspring 100% is several months naturally-occurring hypertension after birth, but this rat model does not consider environment and the effect of dietary factor in hypertension model forming process, and this model prices is expensive.Renovascular hypertension animal model causes RAS with modus operandi, and peripheral resistance increases, and causes blood pressure to increase, but this model lethality is high, become mould unstable and do not meet essential hypertension forming process.Neuron specific emelase animal model causes nerve by modus operandi nerve, causes elevation of the blood pressure, but this model surgery operating process is complicated, and forming process is also not in full conformity with the process of essential hypertension.Endocrine hypertension animal model prepares model by the subcutaneous desoxycortone capsule and pill that buries in conjunction with chlorination sodium diet, and the preparation of this model is simple, but does not meet the process of spontaneously hypertensive formation.Stress-induced hypertension animal model adopts the models such as electricity, sound wave to stimulate central nervous system to cause high-pressure, causes blood pressure to raise, meet the natural law that original hypertensive rat is formed.But electricity or sonic stimulation need a very long process, and disturb comparatively large to external world, the device that current neither one is suitable.
Summary of the invention
The object of the invention is to solve prior art Problems existing, a kind of rat hypertension model preparation facilities is provided, utilize sonic stimulation, rat can be made at short notice to cause blood pressure to raise, form stable hypertension animal model, blood pressure stabilization, environment does not almost affect to external world, meets the natural law that original hypertensive rat is formed.
The technical solution used in the present invention is: a kind of rat hypertension model preparation facilities, is made up of sound proof box, rat feed groove and kettle bayonet socket; Rat feed groove is arranged in sound proof box, and the top cover of rat feed groove has recessed cambered surface; Kettle bayonet socket is arranged on the lower position place of recessed cambered surface; A high-frequency sound generator is installed at upper angle inside sound proof box.
Further, the upper angle outside described sound proof box corresponds to the position of installing high-frequency sound generator and establishes audio adjuster.
Principle of the present invention causes rat high-pressure, sympathetic activation by long-term sonic stimulation, and blood pressure raises, and meets essential hypertension Forming Mechanism.Design considers that the stimulation of long-term sound can cause interference to environment, and special standby sound proof box, utilize the audibility range of rat for 200Hz-90kHz, and the audibility range of people is the difference of 16Hz-24kHz simultaneously; Design powerful high-power ultrasonic wave impulse effectively disturb muroid auditory system and stimulate, make it stand, and feel panic and uneasy, sympathetic activation, form hypertension.The impact of this frequency on the mankind is simultaneously minimum.
Use the present invention, be put in by rat in this device rat feed groove and normally raise, the high-frequency sound giving 12h every day stimulates, and within 6 weeks, form stable hypertension animal model, blood pressure stabilization, environment does not almost affect to external world.
Compared with the prior art, structure of the present invention is simple, and convenient and practical, the model prepared meets the rule of essential hypertension self-assembling formation, has broad application prospects.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Reference numeral is: 1. sound proof box; 2. rat feed groove; 3. kettle bayonet socket; 4. the top cover of rat feed groove; 5. high-frequency sound generator; 6. audio adjuster.
Embodiment
The present invention is described in detail below in conjunction with accompanying drawing specific embodiment.
A kind of rat hypertension model preparation facilities, be made up of sound proof box (1), rat feed groove (2) and kettle bayonet socket (3), rat feed groove (2) is arranged in sound proof box (1), and the top cover (4) of rat feed groove has recessed cambered surface; Kettle bayonet socket (3) is arranged on the lower position place of recessed cambered surface; At the upper angle of sound proof box (1) inner side, one high-frequency sound generator (5) is installed; The upper angle in described sound proof box (1) outside corresponds to the position of installing high-frequency sound generator (5) and establishes audio adjuster (6).
Described in the present embodiment, the frequency range of high-frequency sound generator (5) is 30kHz-90kHz.
The boxboard of sound proof box 1 described in the present embodiment, adopt double layer glass plate, and wherein inner layer glass plate is safety glass, adopts the aluminium alloy extrusions of hollow to connect in sound proof box 1 corner junction; The opening part of aluminium alloy extrusions has sealant sealing.
Use the present invention, with rat 30, be divided into two groups at random: control group, model group, the free diet drinking-water of control group, model group, rat is put in the hypertension model preparation facilities in the present invention, 12 hours every days, 6 weeks duration.The blood pressure of result control group is 122 ± 23mmHg, model group 178 ± 18mmHg.The two difference of blood pressure has statistical significance.
In sum, be only the preferred embodiment of the present invention, do not limit protection scope of the present invention with this, all equivalence changes done according to the scope of the claims of the present invention and description with modify, be all within scope that patent of the present invention contains.
Claims (4)
1. a rat hypertension model preparation facilities, is made up of sound proof box (1), rat feed groove (2) and kettle bayonet socket (3); It is characterized in that: rat feed groove (2) is arranged in sound proof box (1), the top cover (4) of rat feed groove has recessed cambered surface; Kettle bayonet socket (3) is arranged on the lower position place of recessed cambered surface; At the upper angle of sound proof box (1) inner side, one high-frequency sound generator (5) is installed.
2. a kind of rat hypertension model preparation facilities according to claim 1, is characterized in that, the upper angle in described sound proof box (1) outside corresponds to the position of installing high-frequency sound generator (5) and establishes audio adjuster (6).
3. a kind of rat hypertension model preparation facilities according to claim 1, is characterized in that: the frequency range of described high-frequency sound generator (5) is 30kHz-90kHz.
4. a kind of rat hypertension model preparation facilities according to claim 1, it is characterized in that: the boxboard of described sound proof box (1), adopt double layer glass plate, and wherein inner layer glass plate is safety glass, adopts in sound proof box (1) corner junction the aluminium alloy extrusions of hollow to connect; The opening part of aluminium alloy extrusions has sealant sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510948284.1A CN105379631A (en) | 2015-12-17 | 2015-12-17 | Rat hypertension model preparation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510948284.1A CN105379631A (en) | 2015-12-17 | 2015-12-17 | Rat hypertension model preparation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105379631A true CN105379631A (en) | 2016-03-09 |
Family
ID=55412893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510948284.1A Pending CN105379631A (en) | 2015-12-17 | 2015-12-17 | Rat hypertension model preparation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105379631A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007061387A1 (en) * | 2005-11-24 | 2007-05-31 | Linair Bio-Science Pte. Ltd. | Individual ventilated caging syste |
| US7913650B2 (en) * | 2004-12-13 | 2011-03-29 | Innovive, Inc. | Containment systems and components for animal husbandry |
| CN103300937A (en) * | 2012-03-12 | 2013-09-18 | 复旦大学 | Acousto-optical-electric programmable random stimulator |
| CN203303160U (en) * | 2013-06-20 | 2013-11-27 | 成都泰盟软件有限公司 | Rat hypertension molding instrument |
| CN105123541A (en) * | 2015-07-22 | 2015-12-09 | 苏州新区枫桥净化设备厂 | Multifunctional convenient cage |
| CN205266577U (en) * | 2015-12-17 | 2016-06-01 | 王俊杰 | Rat high blood pressure model preparation facilities |
-
2015
- 2015-12-17 CN CN201510948284.1A patent/CN105379631A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7913650B2 (en) * | 2004-12-13 | 2011-03-29 | Innovive, Inc. | Containment systems and components for animal husbandry |
| WO2007061387A1 (en) * | 2005-11-24 | 2007-05-31 | Linair Bio-Science Pte. Ltd. | Individual ventilated caging syste |
| CN103300937A (en) * | 2012-03-12 | 2013-09-18 | 复旦大学 | Acousto-optical-electric programmable random stimulator |
| CN203303160U (en) * | 2013-06-20 | 2013-11-27 | 成都泰盟软件有限公司 | Rat hypertension molding instrument |
| CN105123541A (en) * | 2015-07-22 | 2015-12-09 | 苏州新区枫桥净化设备厂 | Multifunctional convenient cage |
| CN205266577U (en) * | 2015-12-17 | 2016-06-01 | 王俊杰 | Rat high blood pressure model preparation facilities |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160309 |
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| WD01 | Invention patent application deemed withdrawn after publication |