CN105362617A - Medicine for treating chronic urinary retention and preparation method of medicine - Google Patents
Medicine for treating chronic urinary retention and preparation method of medicine Download PDFInfo
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- CN105362617A CN105362617A CN201510876735.5A CN201510876735A CN105362617A CN 105362617 A CN105362617 A CN 105362617A CN 201510876735 A CN201510876735 A CN 201510876735A CN 105362617 A CN105362617 A CN 105362617A
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Abstract
The invention discloses a medicine for treating chronic urinary retention and a preparation method of the medicine. The medicine is mainly prepared from root of red-rooted salvia, cicada slough, bitter orange, white atractylodes rhizome, asarum, tenuifolia, rattletop, rhizoma anemarrhenae, akebiaquinata, liquorice, golden cypress, cloves and semen plantaginis according to a certain weight ratio. The medicine has the functions of purging intense heat, excreting water, nourishing yin for lowering fire, moisturizing pathogenic dryness to loosen the bowel, promoting urination and clearing heat. The medicine for treating the chronic urinary retention is rapid in effect and fine in curative effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of chronic urinary retention and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Chronic urinary retention onset is slow, and the course of disease is longer, and concrete symptom is for intravesical is full of urine and can not normally discharge, and hypogastric region can touch the bladder being full of urine, but patient can not empty bladder.Because current Western medicine effectively cannot treat chronic urinary retention, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment chronic urinary retention, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment chronic urinary retention, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment chronic urinary retention.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Salviae Miltiorrhizae, Periostracum Cicadae, Fructus Aurantii, the Rhizoma Atractylodis Macrocephalae, Herba Asari, Herba Schizonepetae, Rhizoma Cimicifugae, the Rhizoma Anemarrhenae, Caulis Akebiae, Radix Glycyrrhizae, Cortex Phellodendri, Flos Caryophylli, Semen Plantaginis medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat chronic urinary retention.Radix Salviae Miltiorrhizae is wherein selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus because its nature and flavor are bitter, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Periostracum Cicadae to be because its property sweet-salty, cool, enter lung, Liver Channel, have loose wind heat, lung qi dispersing, determine the function of convulsion, control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, and rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Fructus Aurantii is selected to be because its nature and flavor toil, cool, enter lung, spleen, large intestine channel, have dispelling the stagnated QI, row expectorant, the function of removing food stagnancy, control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Herba Schizonepetae to be that temperature, enters lung, Liver Channel, deliver, dispel the wind, the function for the treatment of blood disorders because its nature and flavor are pungent, parch to black stops blooding, and cure cold heating, headache, laryngopharynx swelling and pain, apoplexy locked mouth, and spit blood, epistaxis, has blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.The Rhizoma Anemarrhenae is selected to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, have nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Caulis Akebiae is selected to be that cool, enter the heart, small intestinal, urinary bladder channel, have pathogenic fire purging row water, the function of promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis because its nature and flavor are bitter.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Cortex Phellodendri is selected to be because its nature and flavor are bitter, cold, enter kidney, urinary bladder channel, have heat clearing away, dampness, pathogenic fire purging, the function of removing toxic substances, control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Select Flos Caryophylli to be because its nature and flavor are pungent, temperature, enter stomach, spleen, kidney channel, have warming middle-JIAO, warming the kidney, the function of sending down the abnormal ascending QI, controls singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, tinea disease.Semen Plantaginis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, and arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view because its nature and flavor are sweet.
Detailed description of the invention
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each grouping all has good therapeutic effect within the scope of following weight:
Radix Salviae Miltiorrhizae 5-12 gram, Periostracum Cicadae 4-10 gram, Fructus Aurantii 5-15 gram,
Rhizoma Atractylodis Macrocephalae 10-20 gram, Herba Asari 10-20 gram, Herba Schizonepetae 12-20 gram,
Rhizoma Cimicifugae 5-16 gram, Rhizoma Anemarrhenae 5-15 gram, Caulis Akebiae 6-18 gram,
Radix Glycyrrhizae 10-20 gram, Cortex Phellodendri 5-15 gram, Flos Caryophylli 5-15 gram, Semen Plantaginis 4-10 gram
Be preferably:
Radix Salviae Miltiorrhizae 6 grams, Periostracum Cicadae 6 grams, Fructus Aurantii 10 grams,
The Rhizoma Atractylodis Macrocephalae 15 grams, Herba Asari 15 grams, Herba Schizonepetae 16 grams,
Rhizoma Cimicifugae 12 grams, the Rhizoma Anemarrhenae 10 grams, Caulis Akebiae 12 grams,
15 grams, Radix Glycyrrhizae, Cortex Phellodendri 10 grams, Flos Caryophylli 10 grams, Semen Plantaginis 6 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
2, Periostracum Cicadae: pick decontamination, cleans and dries;
3, Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and can pinch doubling for degree with hands, section, dries;
4, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
5, Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;
6, Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
7, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
8, the Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
9, Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;
10, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
11, Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
12, Flos Caryophylli: look for decontamination, bennet, sieve dedust bits, the used time smashs to pieces;
13, Semen Plantaginis: pick decontamination, sieve removes spare, empty grain.
Two, prepare
1, described Radix Salviae Miltiorrhizae, Periostracum Cicadae, Fructus Aurantii, the Rhizoma Atractylodis Macrocephalae, Herba Asari, Herba Schizonepetae, Rhizoma Cimicifugae, the Rhizoma Anemarrhenae, Caulis Akebiae, Radix Glycyrrhizae, Cortex Phellodendri, Flos Caryophylli, Semen Plantaginis are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses to take.
Medicine of the present invention has pathogenic fire purging row water, nourishing YIN to lower pathogenic fire, moisturizes the function of laxation, diuretic heat clearing away, is used for the treatment of chronic urinary retention instant effect, good effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 32 examples for medical treatment.
2, diagnostic criteria
Chronic urinary retention shows as not smooth, frequent micturition of urinating more, often has urine retention sense, sometimes has urinary incontinence.Though a few patients is without obvious chronic urinary retention obstruction, but often existing obvious upper urinary tract dilatation, hydronephrosis, even there is symptoms of uremia, as physical weakness, anemia, breathing have urine stink, anorexia, nausea and vomiting, anemia, serum creatinine and blood urea nitrogen rising etc.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, every day two doses, each potion, takes medicine 30 days continuously sooner or later.
4, efficacy assessment standard
Effective: chronic urinary retention symptom is controlled, occur recovering sign, urinate normal gradually.
Take a turn for the better: chronic urinary retention disease states alleviates, patient's sense of discomfort reduces, and the state of an illness progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy chronic urinary retention patient 32 example of the present invention, effective 27 examples of result, obvious effective rate is 84.38%, and take a turn for the better 2 examples, and improvement rate is 6.25%, and invalid 3 examples, total effective rate is 90.63%.
Claims (3)
1. treat a medicine for chronic urinary retention, it is characterized in that: it is made up of the crude drug in following weight range:
Radix Salviae Miltiorrhizae 5-12 gram, Periostracum Cicadae 4-10 gram, Fructus Aurantii 5-15 gram,
Rhizoma Atractylodis Macrocephalae 10-20 gram, Herba Asari 10-20 gram, Herba Schizonepetae 12-20 gram,
Rhizoma Cimicifugae 5-16 gram, Rhizoma Anemarrhenae 5-15 gram, Caulis Akebiae 6-18 gram,
Radix Glycyrrhizae 10-20 gram, Cortex Phellodendri 5-15 gram, Flos Caryophylli 5-15 gram, Semen Plantaginis 4-10 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Salviae Miltiorrhizae 6 grams, Periostracum Cicadae 6 grams, Fructus Aurantii 10 grams,
The Rhizoma Atractylodis Macrocephalae 15 grams, Herba Asari 15 grams, Herba Schizonepetae 16 grams,
Rhizoma Cimicifugae 12 grams, the Rhizoma Anemarrhenae 10 grams, Caulis Akebiae 12 grams,
15 grams, Radix Glycyrrhizae, Cortex Phellodendri 10 grams, Flos Caryophylli 10 grams, Semen Plantaginis 6 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
(2) Periostracum Cicadae: pick decontamination, cleans and dries;
(3) Fructus Aurantii: removing flesh, core, edulcoration, slightly soaks, and pulls out, softens, and can pinch doubling for degree with hands, section, dries;
(4) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(5) Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;
(6) Herba Schizonepetae: pick clean impurity, with water slightly bubble, pulls cutting out, dries;
(7) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(8) Rhizoma Anemarrhenae: pick clean impurity, hit with water and wash, pull out, soften, section is dried;
(9) Caulis Akebiae: slightly soak with water, moistening, to thoroughly, is cut into slices, is dried;
(10) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;
(11) Cortex Phellodendri: pick decontamination, washes, and pulls out, runs through, and section or shredding, dry;
(12) Flos Caryophylli: look for decontamination, bennet, sieve dedust bits, the used time smashs to pieces;
(13) Semen Plantaginis: pick decontamination, sieve removes spare, empty grain;
(2) prepare
(1) described Radix Salviae Miltiorrhizae, Periostracum Cicadae, Fructus Aurantii, the Rhizoma Atractylodis Macrocephalae, Herba Asari, Herba Schizonepetae, Rhizoma Cimicifugae, the Rhizoma Anemarrhenae, Caulis Akebiae, Radix Glycyrrhizae, Cortex Phellodendri, Flos Caryophylli, Semen Plantaginis are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filter first time decoction liquor;
(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;
(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into two doses to take.
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