CN105343529A - Traditional Chinese medicine composition for treating gastric ulcer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gastric ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gastric ulcer and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of umbrella sedge, 5 to 10 parts of rhizoma atractylodis macrocephalae, 20 to 30 parts of rhizoma polygonati, 1 to 5 parts of xanthiun sibiricum patrin ex widder, 20 to 30 parts of iron stick yam, 1 to 5 parts of adenophora stricta, 1 to 5 parts of ligusticum chuanxiong hort, 1 to 5 parts of euphorbia kansui, 5 to 10 parts of rehmannia glutinosa, 10 to 20 parts of fructus terminaliae immaturus, 5 to 10 parts of common achyranthes herb, 10 to 20 parts of liquorice, 10 to 20 parts of fructus rosae laevigatae, 5 to 10 parts of flax, 5 to 10 parts of rhodiola rosea and 5 to 10 parts of angelica sinensis. All of the raw materials are subjected to alcohol extraction and water extraction, and are crushed, mixed and concentrated into an extract, so as to obtain the traditional Chinese medicine composition for treating the gastric ulcer. The traditional Chinese medicine components for treating the gastric ulcer are natural traditional Chinese medicinal materials, the purpose of completely curing is achieved by balancing yin and yang, strengthening the spleen and the stomach and regulating the viscera, an obvious curative effect of treating chronic gastritis and the gastric ulcer is achieved, and the course of treatment is short.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically Chinese medicine composition for the treatment of gastric ulcer and preparation method thereof.
Background technology
Gastropathy, is actually the general designation of many diseases.They have similar symptom, as upper abdomen gastral cavilty portion discomfort, pain, after meal glutted, belch, return acid, even Nausea and vomiting etc.Gastropathy common clinically has the innocent and malignant tumour of acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, polyp of stomach, gastric calculus, stomach, also has prolapse of gastric mucosa, acute gastric dilatation, pyloric obstruction etc.The cause of disease of gastropathy: 1. after acute gastritis, mucosal lesion is not healed lastingly.2. helicobacter pylori infections.3. drink spirits strong tea espresso for a long time and eat the unreasonable living habit such as pungent and coarse food smoking.4. often take and have infringement and medicine excitatory, as aspirin, indometacin, glucocorticoid, antitumor drug etc. to gastric mucosa.5. some chronic diseases, as chronic nephritis, uremia, severe diabetes etc.Modal have epigastric discomfort or pain, nausea,vomiting,diarrhea, inappetence.The symptom of gastritis and duodenal ulcer is then epigastrium burning pain, particularly between two meals, early occurs before the meal or after drinking orange juice, coffee.Severe patient can have tarry stool, melena or hemafecia.
Chronic gastritis refers to that the gastric mucosa chronic inflammatory disease caused by a variety of causes changes.A kind of disease the most common and frequently-occurring disease.Feature be male's sickness rate higher than women, and sickness rate is in rising trend with age.After chronic gastritis its essence is that gastric epithelial suffers repeatedly to damage, due to the regeneration capacity that mucosa is special, so that mucosa is reconstructed, and finally causes the atrophy of irreversible intrinsic gastric gland body, even disappears.
Peptic Ulcers or peptic ulcer are a kind of common digestive tract disease, esophagus, stomach or duodenum can be betided, also can betide near stomach-intestinal anastomosis mouth or containing in the Meckel diverticulum of gastric mucosa, because gastric ulcer and duodenal ulcer the most common, therefore general so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.Why it is referred to as peptic ulcer, because previously think that gastric ulcer and duodenal ulcer are because gastric acid and pepsin formed mucosa autodigestion, in fact gastric acid and pepsin are the one of the main reasons of ulcer, also have other reasons to form peptic ulcer.
The medicament categories of current treatment gastric ulcer is various, comprises Chinese medicine and Western medicine.Because long-term taking Western medicine can produce certain toxic and side effects, patients with gastric disease takes Chinese medicine mostly.Chinese medicine is in the market longer for the course for the treatment of, and usually take one month or some months just course for the treatment of, reach thorough recovery from illness also needs several course for the treatment of, makes troubles to patient.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of the treatment gastric ulcer of short treating period, instant effect and preparation method thereof, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
The Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Polygonati 20-30 part, Herba Xanthii grass 1-5 part, Rhizoma Dioscoreae 20-30 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Rhizoma Chuanxiong 1-5 part, Radix Kansui 1-5 part, Radix Rehmanniae Preparata 5-10 part, FRUCTUS TERMINALIAE IMMATURUS 10-20 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 5-10 part, Radix Glycyrrhizae 10-20 part, Fructus Rosae Laevigatae 10-20 part, linum 5-10 part, Radix Rhodiolae 5-10 part, Radix Angelicae Sinensis 5-10 part.
As the further scheme of the present invention: the Chinese medicine composition of described treatment gastric ulcer, be made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 6-8 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Rhizoma Polygonati 23-26 part, Herba Xanthii grass 2-4 part, Rhizoma Dioscoreae 23-26 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Radix Adenophorae (Radix Glehniae) 2-4 part, Rhizoma Chuanxiong 2-4 part, Radix Kansui 2-4 part, Radix Rehmanniae Preparata 6-8 part, FRUCTUS TERMINALIAE IMMATURUS 13-16 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 6-8 part, Radix Glycyrrhizae 13-16 part, Fructus Rosae Laevigatae 13-16 part, linum 6-8 part, Radix Rhodiolae 6-8 part, Radix Angelicae Sinensis 6-8 part.
As the further scheme of the present invention: the Chinese medicine composition of described treatment gastric ulcer, be made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Rhizoma Polygonati 25 parts, Herba Xanthii grass 3 parts, Rhizoma Dioscoreae 25 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Adenophorae (Radix Glehniae) 3 parts, Rhizoma Chuanxiong 3 parts, Radix Kansui 3 parts, 7 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 15 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 7 parts, 15 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 15 parts, linum 7 parts, Radix Rhodiolae 7 parts, Radix Angelicae Sinensis 7 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae weight 8-10 dehydrated alcohol doubly carries out stirring and extracts, Extracting temperature is 55-60 DEG C, extraction time is 4-5h, speed of agitator is 150-200rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3000-3500rpm/min, centrifugation time is 10-15min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 60-70 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 12-14 times weight, stir and extract, Extracting temperature is 50-55 DEG C, extraction time is 3-4h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 40-45 DEG C, and extraction time is 3-4h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
As the further scheme of the present invention: be used for the treatment of chronic gastritis and gastric ulcer.
The mechanism of action of each Chinese medicine in the present invention: Herba Cyperi Flabelliformis detoxifies.Main chronic otitis media; Traumatic injury.
The Rhizoma Atractylodis Macrocephalae has negative chronotropic, reduces myocardial oxygen consumption, improves myocardial ischemia, the effect such as antiplatelet aggregation and arrhythmia.Cordyceps Sinensis extract has obvious protective effect to acute viral myocarditis.The damage of the Rhizoma Atractylodis Macrocephalae to thrombocytopenia and Ultrastructure of Platelets all has significant protective effect, has obvious hypotensive effect to pentobarbital sodium anesthesia.Cordyceps Aqueous extracts has stronger coronary artery dilator and increases the function of coronary flow.Cordyceps extract can promote platelet aggregation and play anastalsis, its alcohol extract energy inhibition thrombosis.The Rhizoma Atractylodis Macrocephalae obviously can strengthen adrenergic expansion bronchus effect, regulates bronchial smooth muscle, alleviates the symptoms such as senile chronic bronchitis, asthma, emphysema, pulmonary heart disease, delay recurrence time.Cordycepin causes the pathogenic bacteria of pulmonary infection to have strong inhibition and killing action to tubercule bacillus etc. simultaneously, and cordycepic acid and Cordyceps polysaccharide can repair alveolar cell in damaged condition.The Rhizoma Atractylodis Macrocephalae is just mainly manifested in a series of protection of liver and control the effect of digestive system.(1) Rhizoma Atractylodis Macrocephalae can improve patient's liver function, and alleviate the inflammatory cell infiltration regulating liver-QI wall regeneration of liver, Cordyceps mycelium has stronger hepatocyte repair; (2) cordyceps sinensis polysaccharide liposome (CPL) has certain protective effect to the hepatic tissue that CCl4 damages; (3) Rhizoma Atractylodis Macrocephalae aqueous solution can suppress liver Ito Cells to be bred, and liver Ito Cells can also be suppressed to transform to myofibroblasts and fibroblast.
Rhizoma Polygonati promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.Sallow smart dyspepsia and intestinal stasis relieving effect strengthens.For meat stagnation, dysentery is not well.
Herba Xanthii grass fruit is diaphoresis, and diuresis is antipyretic, medicine for dispelling toxin.There is spasmolytic, analgesic activity.Control myoneural paralysis, arthralgia, the diseases such as edema.Stem, leaf mash painting scabies, wet disease, insect bite.To leprosy and dysentery effective in cure.Nearly useful radical cure hypertension.
Rhizoma Dioscoreae, containing saponin, phlegmatic temperament, choline, Rhizoma Dioscoreae alkali, starch, glycoprotein, free amino acid, polyphenol oxidase, vitamin C, iodine matter, 16 seed amino acids, also has the various trace elements such as selenium, ferrum, copper, zinc, manganese, calcium.Sweet in the mouth, property be flat, nontoxic, have spleen invigorating, tonifying the lung, reinforce the kidney, beneficial brain, beneficial intensive culture face, defying age, antitumor, resisting fatigue, anti-harmful substance stimulate, regulate metabolism, strengthen immune function, growth promoting effects, endocrine regulation, adjustment cardio-pulmonary function, excited blood system processed, nervous system regulation.
Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The impact of the Rhizoma Atractylodis Macrocephalae on isolated small intestines of rabbits spontaneous activity is how not identical, it is movable that the Rhizoma Atractylodis Macrocephalae can strengthen Isolated rabbit intestine Spontaneous Contraction, its shrinkage amplitude is strengthened, and Rhizoma Atractylodis Macrocephalae oil suppresses the autonomic movement of intestinal tube, or the autonomic movement impact of the Rhizoma Atractylodis Macrocephalae on isolated small intestines of rabbits is not obvious.The Rhizoma Atractylodis Macrocephalae has obvious antagonism to the isolated small intestines of rabbits tetanic contraction caused by acetylcholine, dichloride barium, and to the suppression of the isolated rabbit small intestinal activity added caused by epinephrine, the Rhizoma Atractylodis Macrocephalae can this effect of antagonism.But also there is report there is no obvious antagonism.Rhizoma Atractylodis Macrocephalae decoct 10g(every day crude drug/kg obviously can promote the synthesis of Protein in small intestine to continuously mouse stomach.Rhizoma Atractylodis Macrocephalae extract 50mg and 200mg/kg gastric infusion, to animal water-immersion restraint stress ulcer, have and show inhibition.
Radix Adenophorae (Radix Glehniae) is astringed the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Radix Adenophorae (Radix Glehniae) is on the impact of immunologic function: energy enhancing body is to the defence capability of nonspecific stimulation.Radix Adenophorae (Radix Glehniae) antibacterial action: ethanol immersion all has inhibitory action to anthrax bacillus, staphylococcus aureus, Staphylococcus albus, Bacillus typhi, vibrio cholera etc. in vitro.
Rhizoma Chuanxiong is containing ligustrazine (chuanxiongzine) i.e. tetramethylpyazine (te-tramethylpyrazine), loline or containing river diindyl (perlolyrine) i.e. 1-(5-methylol-2-furyl)-9h-pyrido [3, 4-b] and indole [1-(5hydroxymethyl-2-furyl)-9H-pyrido [3, 4-b] indole], ligustilide (ligustilide), Rhizoma Chuanxiong naphthalene furan lactone (wallichilide), 3-butylidenephthalide (3-butylideniphthalide), 3-butylidene-7-hydroxyl Phthalide (3-butylidene-7-hydroxyphthalide) etc., wherein ligustrazine energy coronary artery dilator, increase coronary artery blood flow, improve the blood oxygen supply of cardiac muscle, and reduce the oxygen consumption of cardiac muscle, the expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation, can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis, the neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle, water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect, the absorption of fracture local hematoma can be accelerated, promote callus formation, there is the effect of vitamin antagonist E shortage, multiple bacillus can be suppressed, there are antihistaminic and choleretic effect.
Radix Kansui removing water retention by purgation by swollen, dispersing swelling and dissipating binds.Cure mainly edema; Ascites; Prolonged fluid-retention blocked-up chest; Epilepsy; Breath with cough; Sphincter disturbance.
Radix Rehmanniae Preparata is enriched blood yin nourishing, life essence-filling, marrow-benefitting.Radix Rehmanniae Preparata water decoction gavages every 0.5g to posthemorrhagic anemia mice, every day 1 time, continuous 10 days, the recovery of anemia animal erythrocyte, hemoglobin can be promoted, accelerate propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E).Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis stove and simple necrosis.To the hyperlipemia that high lipid food causes, the hepatic vein hemorrhage that fatty liver and rat endotoxin cause, all has the effect of inhibition thrombosis.Thinking activation to plasminogen, is antithrombotic mechanism of action.Radix Rehmanniae Preparata alcohol extract, to mouse gavaging, has significant protective effect to the macrophage function suppressed by carrageenin; Antagonist forms cell inhibitory action.Radix Rehmanniae Preparata and cook Radix Rehmanniae and have significant hypotensive effect, systolic pressure and diastolic pressure all significantly decline.
FRUCTUS TERMINALIAE IMMATURUS clearing away heat and promoting production of body fluid, removing toxic substances.Cure mainly deficiency of YIN diphtheria.
Radix achyranthis asperae (Herba Achyranthis Asperae) heat clearing away, induces sweat, and diuretic is invigorated blood circulation.Cure mainly: cold, fever, dysentery, malaria, laryngalgia, beriberi, gonorrhea.Edema, traumatic injury.
Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Fructus Rosae Laevigatae controlling nocturnal emission with astringent drugs reducing urination, stopping metrorrhagia and leukorrhagia, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.
Linum flex seed oil content 30%-45%, oleum lini is rich in the unsaturated fatty acid such as linolenic acid, linoleic acid, and be particularly rich in the necessary a-linolenic acid of human body and r-linolenic acid, wherein a-linolenic acid accounts for 57% of linseed oil fatty acid, higher than fish oil 2 times.Human blood-pressure, serum cholesterol, blood viscosity can be reduced, have therapeutic effect to cancer, cardiovascular diseases, splanchnopathy, nephropathy, dermatosis, arthritis, pneumonopathy, immune system disease etc.
Radix Rhodiolae benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Radix Angelicae Sinensis has enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.Anticancer, anti-ageing anti-old, immune effect in addition.The synthesis of Radix Angelicae Sinensis to DNA, RNA has facilitation.Clinical confirmation, Radix Angelicae Sinensis can make patient's thymol turbidity reduce.Radix Angelicae Sinensis diet mice, hepatic tissue endogenous is breathed and is strengthened, and the ability of oxidation glutamic acid significantly improves.There is protective effect to hepatic injury caused by carbon tetrachloride, and can prevent liver glycogen from reducing.Experiment and clinically all to prove, Radix Angelicae Sinensis has effect for reducing blood fat to hyperlipemia, and its effect is similar with medicines such as clofibrates.To in animal and human's isolated cells 2,3-diphosphonic acid generates facilitation, reduce hemoglobin and the affinity of oxygen, promote to be with oxygen hemoglobin to discharge oxygen in the tissue, thus add the function of erythrocyte transport oxygen.
Compared with prior art, the invention has the beneficial effects as follows: the Chinese medicinal components of the treatment gastric ulcer in the present invention is natural Chinese medicine, by Yin Yang balancing, strengthen the spleen and stomach, object that conditioning viscera reaches thoroughly radical cure, especially significant curative effect is had to treatment chronic gastritis and gastric ulcer, short treating period, such as controlling a course for the treatment of of gastropathy is 7 days, can take effect in general three or four courses for the treatment of.Secondly, instant effect, patient takes rear stomach and has comfort soon, and after taking 5 day period 1, the clinical symptoms such as gastropathy gastric acid flatulence disappears substantially.Through clinical 100 example checkings, total effective rate is 99%, and cure rate is 93%.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, the Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Rhizoma Polygonati 20 parts, Herba Xanthii grass 1 part, Rhizoma Dioscoreae 20 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Adenophorae (Radix Glehniae) 1 part, Rhizoma Chuanxiong 1 part, Radix Kansui 1 part, 5 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 10 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 5 parts, 10 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 10 parts, linum 5 parts, Radix Rhodiolae 5 parts, Radix Angelicae Sinensis 5 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, the dehydrated alcohol that Radix Rhodiolae weight is 8 times carries out stirring and extracts, Extracting temperature is 55 DEG C, extraction time is 4h, speed of agitator is 150rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3000rpm/min, centrifugation time is 15min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 60 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 12 times of weight, stir and extract, Extracting temperature is 50 DEG C, extraction time is 3h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 40 DEG C, and extraction time is 3h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
Embodiment 2
In the embodiment of the present invention, the Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Polygonati 30 parts, Herba Xanthii grass 5 parts, Rhizoma Dioscoreae 30 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Adenophorae (Radix Glehniae) 5 parts, Rhizoma Chuanxiong 5 parts, Radix Kansui 5 parts, 10 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 20 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 parts, 20 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 20 parts, linum 10 parts, Radix Rhodiolae 10 parts, Radix Angelicae Sinensis 10 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, the dehydrated alcohol that Radix Rhodiolae weight is 10 times carries out stirring and extracts, Extracting temperature is 60 DEG C, extraction time is 5h, speed of agitator is 200rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3500rpm/min, centrifugation time is 10min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 70 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 14 times of weight, stir and extract, Extracting temperature is 55 DEG C, extraction time is 4h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 45 DEG C, and extraction time is 4h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
Embodiment 3
In the embodiment of the present invention, the Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Rhizoma Polygonati 23 parts, Herba Xanthii grass 2 parts, Rhizoma Dioscoreae 23 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Radix Adenophorae (Radix Glehniae) 2 parts, Rhizoma Chuanxiong 2 parts, Radix Kansui 2 parts, 6 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 13 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 6 parts, 13 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 13 parts, linum 6 parts, Radix Rhodiolae 6 parts, Radix Angelicae Sinensis 6 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, the dehydrated alcohol that Radix Rhodiolae weight is 8.5 times carries out stirring and extracts, Extracting temperature is 56 DEG C, extraction time is 4.2h, speed of agitator is 160rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3100rpm/min, centrifugation time is 11min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 62 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 12.5 times of weight, stir and extract, Extracting temperature is 52 DEG C, extraction time is 3.3h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 42 DEG C, and extraction time is 3.3h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
Embodiment 4
In the embodiment of the present invention, the Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Rhizoma Polygonati 26 parts, Herba Xanthii grass 4 parts, Rhizoma Dioscoreae 26 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Radix Adenophorae (Radix Glehniae) 4 parts, Rhizoma Chuanxiong 4 parts, Radix Kansui 4 parts, 8 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 16 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 8 parts, 16 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 16 parts, linum 8 parts, Radix Rhodiolae 8 parts, Radix Angelicae Sinensis 8 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, the dehydrated alcohol that Radix Rhodiolae weight is 9.5 times carries out stirring and extracts, Extracting temperature is 58 DEG C, extraction time is 4.8h, speed of agitator is 180rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3400rpm/min, centrifugation time is 14min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 68 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 13.5 times of weight, stir and extract, Extracting temperature is 54 DEG C, extraction time is 3.8h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 44 DEG C, and extraction time is 3.8h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
Embodiment 5
In the embodiment of the present invention, the Chinese medicine composition for the treatment of gastric ulcer, is made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Rhizoma Polygonati 25 parts, Herba Xanthii grass 3 parts, Rhizoma Dioscoreae 25 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Adenophorae (Radix Glehniae) 3 parts, Rhizoma Chuanxiong 3 parts, Radix Kansui 3 parts, 7 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 15 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 7 parts, 15 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 15 parts, linum 7 parts, Radix Rhodiolae 7 parts, Radix Angelicae Sinensis 7 parts.
The preparation method of the Chinese medicine composition of described treatment gastric ulcer, is made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, the dehydrated alcohol that Radix Rhodiolae weight is 9 times carries out stirring and extracts, Extracting temperature is 57 DEG C, extraction time is 4.5h, speed of agitator is 175rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3300rpm/min, centrifugation time is 12min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 65 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 13 times of weight, stir and extract, Extracting temperature is 52 DEG C, extraction time is 3.5h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 42 DEG C, and extraction time is 3-4h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
The Chinese medicine composition of the treatment gastric ulcer in the embodiment of the present invention is applied to clinical, and general employing is oral, and takes three day, within early, middle and late one hour after meal, take warm water and take, each 0.3-0.5g, for verifying therapeutic effect of the present invention, enumerates clinical case as follows:
Case 1: Wang, female, 42 years old, abdominal part distending pain, red tongue BOHUANG greasy coating when examining, tell at sunset with towards food, vomiting out in the morning what eaten at last night, tell rear upper abdomen distending pain and disappear, oneself several months, be diagnosed as depression of liver-QI, stomach-QI being unable to descend normally, deficiency of YIN of the spleen and stomach, chronic gastroenteritis, incoordination between the liver and stomach, rear oral medicine, epigastric distending pain after 7 days, gastral cavilty are scorching hot, singultus takes a turn for the better incessantly all to some extent, after taking medicine 30 days, all fully recover.
Case 2: Cai, man, 61 years old, when examining, two coerced that hidden distending pain, gastralgia, epigastric distending pain, singultus are more than, limbs fatigue, poor appetite lack of appetite, oneself has more than 2 years time, be diagnosed as incoordination between the liver and stomach, deficiency of stomach-Yin, rear oral medicine, after 7 days, two side of body dull pain, gastralgia take a turn for the better to some extent, significant curative effect is had after taking 30 days again, face is ruddy, and diet increases, and takes after 2 months and fully recovers.
Case 3: husky certain, female, 35 years old, when examining, two coerced that dull pain, gastral cavilty are scorching hot, poor appetite lack of appetite, morning bitter taste very, emaciated physique, the whole body are weak, oneself, are diagnosed as incoordination between the liver and stomach six months, oral medicine afterwards, after 5 days, two coerce dull pain, gastral cavilty is scorching hot takes a turn for the better to some extent, and taking this medicine has significant curative effect in 20 days, takes after 2 months and fully recovers.
Case 4: sternly certain, man, 53 years old, epigastric distending pain when examining, singultus was more than, acid regurgitation gulps down corruption, gastral cavilty is scorching hot, oneself six months, was diagnosed as liver deficiency of stomach-YIN, rear oral medicine, and two side of body distending pains after taking 3 days, gastral cavilty is scorching hot takes a turn for the better to some extent, took after one month and fully recovered.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. treat the Chinese medicine composition of gastric ulcer, it is characterized in that, be made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 5-10 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Rhizoma Polygonati 20-30 part, Herba Xanthii grass 1-5 part, Rhizoma Dioscoreae 20-30 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Rhizoma Chuanxiong 1-5 part, Radix Kansui 1-5 part, Radix Rehmanniae Preparata 5-10 part, FRUCTUS TERMINALIAE IMMATURUS 10-20 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 5-10 part, Radix Glycyrrhizae 10-20 part, Fructus Rosae Laevigatae 10-20 part, linum 5-10 part, Radix Rhodiolae 5-10 part, Radix Angelicae Sinensis 5-10 part.
2. the Chinese medicine composition for the treatment of gastric ulcer according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 6-8 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Rhizoma Polygonati 23-26 part, Herba Xanthii grass 2-4 part, Rhizoma Dioscoreae 23-26 part, Rhizoma Atractylodis Macrocephalae 6-8 part, Radix Adenophorae (Radix Glehniae) 2-4 part, Rhizoma Chuanxiong 2-4 part, Radix Kansui 2-4 part, Radix Rehmanniae Preparata 6-8 part, FRUCTUS TERMINALIAE IMMATURUS 13-16 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 6-8 part, Radix Glycyrrhizae 13-16 part, Fructus Rosae Laevigatae 13-16 part, linum 6-8 part, Radix Rhodiolae 6-8 part, Radix Angelicae Sinensis 6-8 part.
3. the Chinese medicine composition for the treatment of gastric ulcer according to claim 2, it is characterized in that, be made up of the following raw material according to weight portion: Herba Cyperi Flabelliformis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Rhizoma Polygonati 25 parts, Herba Xanthii grass 3 parts, Rhizoma Dioscoreae 25 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Adenophorae (Radix Glehniae) 3 parts, Rhizoma Chuanxiong 3 parts, Radix Kansui 3 parts, 7 parts, Radix Rehmanniae Preparata, FRUCTUS TERMINALIAE IMMATURUS 15 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 7 parts, 15 parts, Radix Glycyrrhizae, Fructus Rosae Laevigatae 15 parts, linum 7 parts, Radix Rhodiolae 7 parts, Radix Angelicae Sinensis 7 parts.
4. a preparation method for the Chinese medicine composition of the treatment gastric ulcer as described in as arbitrary in claim 1-3, is characterized in that, be made up of following steps:
(1) by Herba Cyperi Flabelliformis, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae mechanical activation comminution, Herba Cyperi Flabelliformis is added after pulverizing, Herba Xanthii grass, Radix Adenophorae (Radix Glehniae), Rhizoma Chuanxiong, Radix Kansui, Radix achyranthis asperae (Herba Achyranthis Asperae), linum, Radix Rhodiolae weight 8-10 dehydrated alcohol doubly carries out stirring and extracts, Extracting temperature is 55-60 DEG C, extraction time is 4-5h, speed of agitator is 150-200rpm/min, after extraction, feed liquid is centrifugal, centrifugal rotational speed is 3000-3500rpm/min, centrifugation time is 10-15min, supernatant Vacuum film evaporation equipment is carried out solvent evaporation, being evaporated to solvent-free outflow is ethanol extract A afterwards,
(2) FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae baking oven are carried out drying, oven temperature is 60-70 DEG C, after drying, FRUCTUS TERMINALIAE IMMATURUS, Fructus Rosae Laevigatae are pulverized, after pulverizing, add the water of its 12-14 times weight, stir and extract, Extracting temperature is 50-55 DEG C, extraction time is 3-4h, with 200 object filter-cloth filterings after extracting, after filtration, filtrate is concentrated, being concentrated into without moisture in concentrate, is water extract B;
(3) blunge after the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Angelicae Sinensis being smashed to pieces extraction, Extracting temperature is 40-45 DEG C, and extraction time is 3-4h, and with 200 object filter-cloth filterings after extracting, being concentrated into without moisture by filtrate after filtration, is water extract C;
(4) Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Rhizoma Dioscoreae are pulverized respectively;
(5) Rhizoma Atractylodis Macrocephalae of ethanol extract A, water extract B, water extract C and pulverizing, Rhizoma Polygonati, Rhizoma Dioscoreae are stirred, after stirring, be condensed into extractum, the Chinese medicine composition of gastric ulcer must be treated.
5., according to the Chinese medicine composition of the arbitrary described treatment gastric ulcer of claim 1-3, it is characterized in that, be used for the treatment of chronic gastritis and gastric ulcer.
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Application publication date: 20160224 |