CN105343405A - Preparation method and application of traditional Chinese medicine composition preparation capable of discharging liver and relieving depression - Google Patents

Preparation method and application of traditional Chinese medicine composition preparation capable of discharging liver and relieving depression Download PDF

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CN105343405A
CN105343405A CN201510921556.9A CN201510921556A CN105343405A CN 105343405 A CN105343405 A CN 105343405A CN 201510921556 A CN201510921556 A CN 201510921556A CN 105343405 A CN105343405 A CN 105343405A
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parts
preparation
composition preparation
chinese medicinal
medicinal composition
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顾晓荣
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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Abstract

The invention discloses a preparation method and application of a traditional Chinese medicine composition preparation capable of discharging liver and relieving depression. The traditional Chinese medicine composition preparation is prepared from the following raw materials in parts by weight: 1 to 5 parts of gorgon fruit, 5 to 15 parts of grifola, 1 to 5 parts of the root of fangji, 5 to 15 parts of the fruit of Chinese wolfberry, 5 to 15 parts of the root of kudzu vine, 5 to 10 parts of the rhizome of chuanxiong, 5 to 10 parts of corydalis tuber, 5 to 10 parts of mangnolia officinalis, 1 to 5 parts of ramulus mori, 1 to 5 parts of astragalus membranaceus, 1 to 5 parts of rhizoma picrorhizae, 1 to 5 parts of Chinese starjasmine stem, 1 to 3 parts of common andrographis herb, 1 to 3 parts of clematis filamentosa, 1 to 3 parts of herba eupatorii, 1 to 3 parts of milklike juice of coconut endosperm, 1 to 3 parts of ferula asafetida, 5 to 10 parts of cyathula prostrata and 5 to 10 parts of capparis acutifolia; the preparation method comprises the steps of taking and smashing the raw materials into coarse powder, performing reflux extraction with an ethanol solution for three times, filtering, recycling ethyl alcohol from filter liquor, cooling and filtering, washing and drying to obtain a Chinese medical extract; then adding medically acceptable auxiliary materials to prepare the traditional Chinese medicine composition preparation. The medicine provided by the invention has the efficacies of discharging liver and relieving depression, and reducing phlegm and resolving masses, is mainly used for curing hyperplasia of mammary glands, is fast in effect, wide in medicinal herbs resource, and low in price.

Description

A kind of preparation method and its usage of Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of preparation method and its usage of Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI.
Background technology
Cyclomastopathy is that cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, and its pathogenic factor is mainly due to endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.Because be women's sexual function the most vigorous period during this period of time.Show as the different parts single-shot of breast or multiple grow some lumps, quality is soft, and obscure boundary is movable, often with pain in various degree.Especially after premenstrual in the moon, tired or the anxious state of mind such as angry (traditional Chinese medical science claims the stagnation of QI) time, lump increases, and pain increases the weight of, and after menstruation, lump obviously reduces, pain relief.Pain is generally distending pain, little tingle.Should remind, cyclomastopathy changes as the possibility of mazalgia, if so suffer from mammary gland have hypertrophy time comparatively elder, should remove examination in hospital, so that timely Diagnosis and Treat.
Western medical treatment cyclomastopathy: the exhausted major part of cystic hyperplasia can use non-operative treatment, holding up the method such as breast with medicated bra can alleviating pain, can take methyl testosterone 3 times on the 1st each 5mg when premenopause, pain was obvious before menstrual onset; Also can oral progesterone 5 ~ 10mg every day the moon premenstrual take 7 ~ 10 days and apply in recent years after vitamin E treatment also has lenitive effect focus to be confined to a part of menstruation of breast still have obvious lump person also can apply operative treatment.5% potassium iodide, pain severe patient can try out methyl testosterone etc.But doctor trained in Western medicine curative effect is not satisfactory, and toxic and side effects is comparatively large, easily recurs, and operative treatment is traumatic comparatively large, and expensive, cause certain economic pressures to patient, patient not easily accepts.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and its usage of Chinese medicinal composition preparation with dispersing the stagnated live-QI to relieve the stagnation of QI, dissipating phlegm and resolving masses effect, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A preparation method for the Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 1-5 part, Polyporus 5-15 part, Radix Stephaniae Tetrandrae 1-5 part, Fructus Lycii 5-15 part, Radix Puerariae 5-15 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Corydalis 5-10 part, Cortex Magnoliae Officinalis 5-10 part, Ramulus Mori 1-5 part, Radix Astragali 1-5 part, Rhizoma Picrorhizae 1-5 part, Caulis Trachelospermi 1-5 part, Herba Andrographis 1-3 part, Clematis filamentosa Dunn 1-3 part, Herba Eupatorii 1-3 part, Sucus Cocois 1-3 part, Resina Ferulae 1-3 part, Herba Cyathulae Prostratae 5-10 part, Radix Capparis Membranaceae 5-10 part; Get above-mentioned raw materials and be broken into coarse powder, doubly add according to the 10-15 of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 3-8h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
As the further scheme of the present invention: described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 2-4 part, Polyporus 8-12 part, Radix Stephaniae Tetrandrae 2-4 part, Fructus Lycii 8-12 part, Radix Puerariae 8-12 part, Rhizoma Chuanxiong 7-9 part, Rhizoma Corydalis 7-9 part, Cortex Magnoliae Officinalis 7-9 part, Ramulus Mori 2-4 part, Radix Astragali 2-4 part, Rhizoma Picrorhizae 2-4 part, Caulis Trachelospermi 2-4 part, Herba Andrographis 1-2 part, Clematis filamentosa Dunn 1-2 part, Herba Eupatorii 1-2 part, Sucus Cocois 1-2 part, Resina Ferulae 1-2 part, Herba Cyathulae Prostratae 7-9 part, Radix Capparis Membranaceae 7-9 part.
As the further scheme of the present invention: described Chinese medicinal composition preparation is used for the treatment of cyclomastopathy.
The mechanism of action of each raw material in the present invention: Semen Euryales supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, eliminating dampness and arresting leucorrhea.For emission and spermatorrhea, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia.
Polyporus has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anticancer, anti-ageing anti-old, immune effect.
Radix Stephaniae Tetrandrae containing volume fatty oil and protein, and contains sterol, triterpenes, Semen Ziziphi Spinosae saponin, volume vitamin C.Can conscience be nourished, calm the nerves, arresting sweating.
Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight.For the sweet flat matter profit of syndrome of yin deficiency of liver and kidney this product, flat invigorating the liver and kidney, has strengthening by means of tonics effect, and all cards of all hepatic and renal YIN deficiency all can be applied.
Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Rhizoma Chuanxiong drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.
Rhizoma Corydalis is invigorated blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.The all pains of main trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.
Cortex Magnoliae Officinalis circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.
Ramulus Mori wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.
The Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting, and hyperactivity of YANG due to deficiency of YIN person, must prohibit clothes.
Reducing the asthenic fever is apt to by Rhizoma Picrorhizae, dispelling fever with infantile malnutrition; Rhizoma Coptidis is kind clearing away heart-fire then, rushes down stomach-fire, is removing toxic substances key medicine.
Caulis Trachelospermi dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
Herba Andrographis has heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.
Clematis filamentosa Dunn: bitter in the mouth, slightly cool in nature; GUIXIN, Liver Channel.Sedation and analgesia, clearing away liver-fire, mind calming god, blood pressure lowering, removing obstruction in the collateral to relieve pain.Main hypertension, insomnia, headache, numb limbs and tense tendons, wind-heat of liver channel, conjunctival congestion and swelling pain, acute toothache, rheumatic arthralgia.Modern medicine study confirms, Clematis filamentosa Dunn is to the symptom improved caused by hypertension, as headache, giddy, feeling of fullness in the head, numb limbs and tense tendons, insomnia etc. has good curative effect, and preliminary observation all has therapeutical effect to the hemiplegic patient caused patients with coronary heart disease and cerebrovas-cularaccident simultaneously.
Herba Eupatorii: acrid in the mouth, property is put down; Return spleen, stomach, lung meridian.Removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.Modern medicine study confirms, Herba Eupatorii 100% water decoction tube dilution method, have inhibitory action to diphtheria corynebacterium, staphylococcus aureus, sarcina, Bacillus proteus, Bacillus typhi etc., its volatile oil infected by influenza also has inhibitory action.
Sucus Cocois: sweet in the mouth, cool in nature.Promote the production of body fluid, diuresis, hemostasis.Main xerostomia excessive thirst, edema, spits blood." Haiyao Bencao, Oversea Materia Medica " carries: " master quenches one's thirst, and spit blood, edema, goes wind heat.”
Resina Ferulae: bitter in the mouth, pungent, warm in nature; Return spleen, stomach warp.Change disease removing food stagnancy, parasite killing preventing the attack (or recurrence) of malaria.Cure mainly lump in the abdomen mass in the abdomen, malnutrition due to parasitic infestation, food stagnation, distension and fullness of the chest and abdomen, cold type of pain, malaria, dysentery.Modern medicine study confirms, the irritant phlegm-dispelling functions of Resina Ferulae, has inhibitory action to Bacillus tuberculosis.
Herba Cyathulae Prostratae: bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.Main carbuncle pyogenic infections from tumour or sore, venom, traumatic injury congestive edema." Chinese herbal medicine handbook is commonly used in Hainan Island " carries: " detumescence, pain relieving, pulls out bullet, except all poison.Control various venom, hepatosplenomegaly, bullet incarnation.”
Radix Capparis Membranaceae: bitter in the mouth, puckery, property is put down, poisonous.Promoting blood circulation to remove blood stasis, relieving spasm to stop pain.For rheumatic arthritis, muscles and bones is not relaxed, laryngopharynx swelling and pain, toothache, and stomachache, amenorrhea, furuncle toxic swelling is controlled in external, traumatic injury.
Compared with prior art, the invention has the beneficial effects as follows:
Medicine of the present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, effect of dissipating phlegm and resolving masses, mainly for treating mammary gland hypertrophy.For different clinical manifestations, stress treatment, instant effect, medicine source is extensive, cheap, makes simple, can carry out clinical market popularization.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a preparation method for the Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 1 part, Polyporus 5 parts, Radix Stephaniae Tetrandrae 1 part, Fructus Lycii 5 parts, Radix Puerariae 5 parts, Rhizoma Chuanxiong 5 parts, Rhizoma Corydalis 5 parts, Cortex Magnoliae Officinalis 5 parts, Ramulus Mori 1 part, the Radix Astragali 1 part, Rhizoma Picrorhizae 1 part, Caulis Trachelospermi 1 part, Herba Andrographis 1 part, Clematis filamentosa Dunn 1 part, Herba Eupatorii 1 part, Sucus Cocois 1 part, Resina Ferulae 1 part, Herba Cyathulae Prostratae 5 parts, Radix Capparis Membranaceae 5 parts; Get above-mentioned raw materials and be broken into coarse powder, add according to 10 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 3h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
Embodiment 2
In the embodiment of the present invention, a preparation method for the Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 5 parts, Polyporus 15 parts, Radix Stephaniae Tetrandrae 5 parts, Fructus Lycii 15 parts, Radix Puerariae 15 parts, Rhizoma Chuanxiong 10 parts, Rhizoma Corydalis 10 parts, Cortex Magnoliae Officinalis 10 parts, Ramulus Mori 5 parts, the Radix Astragali 5 parts, Rhizoma Picrorhizae 5 parts, Caulis Trachelospermi 5 parts, Herba Andrographis 3 parts, Clematis filamentosa Dunn 3 parts, Herba Eupatorii 3 parts, Sucus Cocois 3 parts, Resina Ferulae 3 parts, Herba Cyathulae Prostratae 10 parts, Radix Capparis Membranaceae 10 parts; Get above-mentioned raw materials and be broken into coarse powder, add according to 15 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 8h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
Embodiment 3
In the embodiment of the present invention, a preparation method for the Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 2 parts, Polyporus 8 parts, Radix Stephaniae Tetrandrae 2 parts, Fructus Lycii 8 parts, Radix Puerariae 8 parts, Rhizoma Chuanxiong 7 parts, Rhizoma Corydalis 7 parts, Cortex Magnoliae Officinalis 7 parts, Ramulus Mori 2 parts, the Radix Astragali 2 parts, Rhizoma Picrorhizae 2 parts, Caulis Trachelospermi 2 parts, Herba Andrographis 1 part, Clematis filamentosa Dunn 1 part, Herba Eupatorii 1 part, Sucus Cocois 1 part, Resina Ferulae 1 part, Herba Cyathulae Prostratae 7 parts, Radix Capparis Membranaceae 7 parts; Get above-mentioned raw materials and be broken into coarse powder, add according to 12 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 5h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
Embodiment 4
In the embodiment of the present invention, a preparation method for the Chinese medicinal composition preparation of dispersing the stagnated live-QI to relieve the stagnation of QI, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 4 parts, Polyporus 12 parts, Radix Stephaniae Tetrandrae 4 parts, Fructus Lycii 12 parts, Radix Puerariae 12 parts, Rhizoma Chuanxiong 9 parts, Rhizoma Corydalis 9 parts, Cortex Magnoliae Officinalis 9 parts, Ramulus Mori 4 parts, the Radix Astragali 4 parts, Rhizoma Picrorhizae 4 parts, Caulis Trachelospermi 4 parts, Herba Andrographis 2 parts, Clematis filamentosa Dunn 2 parts, Herba Eupatorii 2 parts, Sucus Cocois 2 parts, Resina Ferulae 2 parts, Herba Cyathulae Prostratae 9 parts, Radix Capparis Membranaceae 9 parts; Get above-mentioned raw materials and be broken into coarse powder, add according to 14 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 6h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
Acute skin irritation test:
These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the preparation prepared by embodiments of the invention 3 to be directly attached on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The formulation dissolution prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore the preparation acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.
Long term toxicity test: the preparation of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
100 cases, the age is between 20-50 year; Be women, the course of disease, between 5 months-11 years, gets rid of pernicious occupy-place through breast molybdenum target and color ultrasound.Patient is divided into 5 groups at random, and often organize each 20 examples, four groups of patients through statistical test zero difference (P > 0.05), have comparability in age, the course of disease, clinical manifestation etc.
Diagnostic criteria
Diagnostic criteria with reference to breast disease Professional Committee of Society of Surgery of China Association of Traditional Chinese Medicine in 2002 is formulated.Standard is as follows:
(1) symptom and sign: breast has distending pain in various degree, twinge and dull pain, can have dependency with menstruation, emotion changes, continuous 3 months or be interrupted and do not alleviate for pain 3-6 month; There is single or multiple lump in breast, lump dispersibles in whole breast, unclear with surrounding tissue boundary, pushes away movable, may touch a tender spot, can the growth and decline with the change of emotion and menstrual cycle, and some patients can have nipple discharge or prurigo.
(2) auxiliary examination: all cases all take the photograph sheet through breast molybdenum target, ultrasound mammography is made a definite diagnosis.
Tcm diagnosis standard:
Based on mastalgia and lump in breast, the growth and decline with menstrual cycle and emotion changes, companion's breast side of body feeling of distension and oppression, insomnia and dreamful sleep, irritable, bitter taste, tongue is dark or red, yellow and thin fur or greasy in vain, stringy and rolling pulse.
(1) primary symptom:
1. mastalgia is main, mostly is distending pain, the growth and decline with menstrual cycle and emotion changes;
2. in breast, Tumor size, soft or hard be not etc.
(2) secondary disease:
1. irritable
2. insomnia and dreamful sleep
3. breast side of body feeling of distension and oppression
4. bitter taste
(3) picture of the tongue: tongue is dark or red, yellow and thin fur or greasy in vain.
(4) pulse condition: stringy and rolling pulse.
Primary symptom possesses, secondary disease possess more than binomial and binomial in conjunction with inspection of the tongue and pulse condition can establish diagnosis and dialectical.
Therapeutic Method:
Oral invention formulation, every day 3 times, each 4 one month is 1 course for the treatment of.
Than group: oral carefree electuary (Changchun Bei Hua pharmaceutical factory, (92) defend No. Z-13, the accurate word of medicine), every bag of 6g.Boiled water is taken after mixing it with water, every day 3 times, starts to take medicine after menstruation terminates, and starts to be 1 course for the treatment of to lower 1 menstrual cycle.
5 groups all judge curative effect after 2 courses for the treatment of of treatment.
Efficacy assessment standard:
Using " the Chinese medical disease Standardization of diagnosis and curative effect " of Ministry of Public Health formulation as efficacy assessment standard,
Clinical cure: lump in breast all disappears, pain disappears, and through three months without recurrence, ultrasound diagnosis cyclomastopathy disappears;
Effective: mass reduction more than 2/3rds, pain disappears, and check B ultrasonic obviously improves before comparatively treating;
Effective: mass reduction more than 1/2nd, pain is obviously alleviated, and check B ultrasonic comparatively treats front improvement;
Invalid: mass reduction is less than 1/2nd, pain is without obviously alleviating or increasing on the contrary, and check B ultrasonic is comparatively treated front without improving.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt the present invention to treat cyclomastopathy, relative to the Chinese medicine of contrast groups on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt the present invention treat cyclomastopathy, relative to the Chinese medicine of contrast groups, treatment the course for the treatment of on significantly shorten.
Table 15 group treats Clinical efficacy comparison table after two courses for the treatment of respectively
Table 25 group treats clinical cure, effective and effective number and time comparative example (%) after two courses for the treatment of respectively
Group Number of cases First course for the treatment of Second course for the treatment of
Embodiment 1 18 10（55.6%） 8（44.4%）
Embodiment 2 18 12（66.7%） 6（33.3%）
Embodiment 3 20 14（70%） 6（30%）
Embodiment 4 20 15（75%） 5（25%）
Matched group 14 6（42.9%） 8（57.1%）
According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
Model case: Lee, female, 38 years old, bilateral breast twinge 3 years, companion's feeling of oppression over the chest and distention of hypochondrium, insomnia and dreamful sleep, irritability, menstrual cycle was normal, measures medium, and color is dark, and body of the tongue is light red, white and thin fur, stringy pulse and carefully puckery.Health check-up: cardiopulmonary are normal, and abdomen is put down soft, 1cm under liver rib, and matter is soft, upper in bilateral breast, the streak lump of extreme term existence is about 2.5cmx3.5cm, tenderness (+).A surpasses inspection when being shown in menstrual onset, and on left breast, quadrant can be visited and the solid section of putting down of 2.3cm, and on right breast, quadrant can be visited and the solid section of putting down of 3.4cm, is and enlivens ripple.Diagnosis: cyclomastopathy.Use the embodiment of the present invention 4, every day 3 times, 1 time 3, treat 1 the course for the treatment of cure, follow up a case by regular visits to and do not recur for 2 years.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.

Claims (3)

1. the preparation method of the Chinese medicinal composition preparation of a dispersing the stagnated live-QI to relieve the stagnation of QI, it is characterized in that, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 1-5 part, Polyporus 5-15 part, Radix Stephaniae Tetrandrae 1-5 part, Fructus Lycii 5-15 part, Radix Puerariae 5-15 part, Rhizoma Chuanxiong 5-10 part, Rhizoma Corydalis 5-10 part, Cortex Magnoliae Officinalis 5-10 part, Ramulus Mori 1-5 part, Radix Astragali 1-5 part, Rhizoma Picrorhizae 1-5 part, Caulis Trachelospermi 1-5 part, Herba Andrographis 1-3 part, Clematis filamentosa Dunn 1-3 part, Herba Eupatorii 1-3 part, Sucus Cocois 1-3 part, Resina Ferulae 1-3 part, Herba Cyathulae Prostratae 5-10 part, Radix Capparis Membranaceae 5-10 part; Get above-mentioned raw materials and be broken into coarse powder, doubly add according to the 10-15 of coarse powder gross weight the alcoholic solution that volumetric concentration is 75%, reflux, extract, three times, return time is 3-8h, and filter, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Add medically acceptable adjuvant again and prepare Chinese medicinal composition preparation.
2. the preparation method of Chinese medicinal composition preparation according to claim 1, it is characterized in that, described Chinese medicinal composition preparation is made up of the following raw material according to weight portion: Semen Euryales 2-4 part, Polyporus 8-12 part, Radix Stephaniae Tetrandrae 2-4 part, Fructus Lycii 8-12 part, Radix Puerariae 8-12 part, Rhizoma Chuanxiong 7-9 part, Rhizoma Corydalis 7-9 part, Cortex Magnoliae Officinalis 7-9 part, Ramulus Mori 2-4 part, Radix Astragali 2-4 part, Rhizoma Picrorhizae 2-4 part, Caulis Trachelospermi 2-4 part, Herba Andrographis 1-2 part, Clematis filamentosa Dunn 1-2 part, Herba Eupatorii 1-2 part, Sucus Cocois 1-2 part, Resina Ferulae 1-2 part, Herba Cyathulae Prostratae 7-9 part, Radix Capparis Membranaceae 7-9 part.
3. a purposes for the Chinese medicinal composition preparation that the preparation method as described in as arbitrary in claim 1-2 obtains, it is characterized in that, described Chinese medicinal composition preparation is used for the treatment of cyclomastopathy.
CN201510921556.9A 2015-12-14 2015-12-14 Preparation method and application of traditional Chinese medicine composition preparation capable of discharging liver and relieving depression Pending CN105343405A (en)

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