CN105340928A - Sterilization composition containing Zhongshengmycin and ametoctradin - Google Patents
Sterilization composition containing Zhongshengmycin and ametoctradin Download PDFInfo
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- CN105340928A CN105340928A CN201510813017.3A CN201510813017A CN105340928A CN 105340928 A CN105340928 A CN 105340928A CN 201510813017 A CN201510813017 A CN 201510813017A CN 105340928 A CN105340928 A CN 105340928A
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- zhongshengmycin
- azoles mepanipyrim
- sterilization composition
- ametoctradin
- bactericidal composition
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Abstract
The invention discloses a sterilization composition containing Zhongshengmycin and ametoctradin. According to the sterilization composition, Zhongshengmycin and ametoctradin are taken as the active ingredients, and weight ratio of Zhongshengmycin to ametoctradin ranges from 30:1 to 1:30; the total weight of Zhongshengmycin and ametoctradin accounts for 5 to 80% of the weight of the sterilization composition; the sterilization composition can be prepared into one agent selected from a suspending agent, a dispersible oil suspended agent, a water dispersible granule, and a wettable powder, is used for preventing and treating crop diseases caused by fungal pathogens, and especially crop downy mildew and phytophthora disease caused by peronospora pathogens. Application amount of the sterilization composition is reduced, spraying times are reduced, application cost is reduced, and the sterilization composition is safe for crops.
Description
Technical field
What the present invention relates to is bactericidal composition, for active ingredient with Zhongshengmycin and azoles mepanipyrim, be applicable to control by pathogen fungi and bacterial crop pest, especially the crop downy mildew, epidemic disease etc. that cause of Peronosporales (Peronosporales) pathogen.
Background technology
Zhongshengmycin (zhongshengmycin); it is a kind of novel agricultural antibiotic; it is the antibiotic produced by the mutation of Strepiomyces lavendulae Hainan; belong to N-glucosides class alkali water-soluble material; the wider protective fungicide of a kind of fungicidal spectrum, have tag, osmosis, Zhongshengmycin has very high activity to the bacterial disease of crops and some fungi venereal disease evil; there is certain production-increasing function simultaneously, use safety.
Zhongshengmycin to crops pathogenic bacteria as dish Bacteria erwinia, avenae subsp.citrull, Xanthomonas oryzae, ring rot of apple germ, fusarium graminearum etc. all have obvious antibacterial activity.By suppressing the peptide bond of pathogenetic bacteria protein to generate, finally cause bacterial death; The growth of mycelia can be suppressed to fungi, suppress the sprouting of spore, play the effect of control fungal disease; Can the generation of the precursor substance of protective plant protecting agent and lignin in stimulating plant body, thus improve the resistance against diseases of plant.
Azoles mepanipyrim (ametoctradin) is triazolo pyrimidine series bactericidal agent, belong to mitochondrial respiratory inhibitor, good inhibitory action is had to Oomycete pathogens such as Peronosporaceae, pythiaceae, Shuan Yimei sections, significantly can affect the formation of zoospore, release and sprouting, there is extremely strong residual activity and rain fastness.
Azoles mepanipyrim is systemic fungicide, has excellent protection, therapeutic activity, holding effect is active and resistance of rainwater washing against is active; Be applicable to downy mildew, the epidemic disease of the crops such as control is melon, solanaceous vegetables, grape.
Found by test, Zhongshengmycin and azoles mepanipyrim used in combination to Peronospora (Peronospora), pythium (Pythium), Phytophthora (Phytophthora), frost Phytophthora (Peronophythora), Pseudoperonospora (Pseudoperonospora), the pathogens such as Plasmopara (Plasmopara) have synergistic function especially in 30:1 ~ 1:30 proportion to Phytophthora (Phytophthora), Pseudoperonospora (Pseudoperonospora), Plasmopara (Plasmopara) pathogen has obvious synergistic effect.Zhongshengmycin and azoles mepanipyrim mixture combine and application there is no report at present.
Summary of the invention
The present invention aims to provide the Synergistic bactericidal composition that a kind of active ingredient is Zhongshengmycin and azoles mepanipyrim, for the prevention and control of crop fungal disease are especially for crop downy mildew, epidemic disease provide one more effective management tool.
The present inventor is by the test of a large amount of indoor bioassay and field medicine effect test, find that Zhongshengmycin and azoles mepanipyrim are with after certain part by weight mixture, have significant synergistic effect to the crop downy mildew, epidemic disease etc. that Peronosporales (Peronosporales) pathogen causes.
On the basis of above-mentioned discovery, after further study, define technical scheme of the present invention, that is: a kind of bactericidal composition containing Zhongshengmycin and azoles mepanipyrim, active ingredient is Zhongshengmycin and azoles mepanipyrim, Zhongshengmycin and azoles mepanipyrim ratio of weight and number are in the composition 30:1 ~ 1:30, and Zhongshengmycin and azoles mepanipyrim weight summation in the composition percentage by weight are 5% ~ 80%, and all the other are the pesticidal preparations auxiliary element that agriculturally can accept and allow to use.
Bactericidal composition of the present invention can be processed into suspending agent, dispersible oil-suspending agent according to well known to a person skilled in the art method, the application forms of the applicable agricultural use such as water dispersible granules, wetting powder.
Bactericidal composition of the present invention is also containing the auxiliary element of preparation needed for pesticidal preparations, comprise one or more mixing in emulsifier, wetting agent, stabilizing agent, dispersant, thickener, defoamer, antifreezing agent, disintegrant, binding agent, filler, filler, medium etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
Bactericidal composition of the present invention, for preventing and treating the crop downy mildew, epidemic disease etc. that cause Peronosporales (Peronosporales) pathogen, should before disease occurs or initial stage of origination use during dispenser.
Bactericidal composition provided by the invention, usually adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, obvious synergy or summation action is shown in certain ratio range, the control efficiency of composition to germ is significantly improved than single dose, reduce the using dosage of agricultural chemicals, decrease times for spraying, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope.
2, bactericidal composition provided by the invention, the combination of two kinds of active ingredients, expands fungicidal spectrum, and a drug can solve multiple diseases problem, compensate for defect when single dose uses and limitation.
3, bactericidal composition provided by the invention, two kinds of active ingredient mechanism of action are not quite identical, can overcome the shortcoming that long-term single use easily produces resistance, extend the service life of medicament, to the comprehensive regulation important in inhibiting of germ resistance.
4, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and it applies huge economic benefit and social benefit.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
According to the abundant method of Sun Yun, the synergy of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), namely CTC≤80 are joint action of antagonism, and 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Actual measurement toxicity index (ATI)=(EC of standard agent
50the EC of/reagent agent
50) × 100; In the toxicity index × mixture of theoretical toxicity index TTI=A medicament the percentage composition+B medicament of A medicament toxicity index × mixture in the percentage composition of B medicament; Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
Embodiment one: Zhongshengmycin azoles mepanipyrim is tested the Toxicity Determination of phytophthora infestans (Phytophthprainfestans).
Subjects picks up from the potato late blight pathogen phytophthora infestans (Phytophthprainfestans) in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T1156.2-2006 ", mycelial growth Plating.
Table 1, Zhongshengmycin azoles mepanipyrim are to the Toxicity Determination result of phytophthora infestans (Phytophthprainfestans)
As shown in Table 1, Zhongshengmycin and azoles mepanipyrim mixture are between 30:1 ~ 1:30, and have obvious synergistic effect to phytophthora infestans (Phytophthprainfestans), co-toxicity coefficient is all more than 150.
Embodiment two: the Toxicity Determination test of Zhongshengmycin azoles mepanipyrim Pseudoperonospora cubensis (Pseudoperonosporacubensis).
Subjects is pick up from the cucumber downy mildew pathogen Pseudoperonospora cubensis (Pseudoperonosporacubensis) in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T1156.3-2006 ", plate blade method.
Table 2, Zhongshengmycin azoles mepanipyrim are to the Toxicity Determination result of Pseudoperonospora cubensis (Pseudoperonosporacubensis)
As shown in Table 2, Zhongshengmycin and azoles mepanipyrim mixture are between 30:1 ~ 1:30, and have obvious synergistic effect to Pseudoperonospora cubensis (Pseudoperonosporacubensis), co-toxicity coefficient is all more than 160.
Embodiment three: Zhongshengmycin azoles mepanipyrim is to the Toxicity Determination test of the raw single shaft of grape mould (Plasmoparaviticola).
Subjects is pick up from the raw single shaft of the downy mildew of garpe pathogen grape mould (Plasmoparaviticola) in field, pot experiment method.
Table 3, Zhongshengmycin azoles mepanipyrim are to the Toxicity Determination result of the raw single shaft of grape mould (Plasmoparaviticola)
As shown in Table 3, Zhongshengmycin and azoles mepanipyrim mixture are between 30:1 ~ 1:30, and have obvious synergistic effect to the raw single shaft of grape mould (Plasmoparaviticola), co-toxicity coefficient is all more than 160.
Embodiment four: 40% Zhongshengmycin azoles mepanipyrim suspending agent.
Zhongshengmycin 10%, azoles mepanipyrim 30%, naphthalene sulfonic acid-formaldehyde condensation product 4%, fatty alcohol-polyoxyethylene ether 5%, glycerine 5%, gum Arabic 1%, deionized water complements to 100%, above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 40% Zhongshengmycin azoles mepanipyrim suspending agent of allotment after high shear mixing.
40% Zhongshengmycin azoles mepanipyrim suspending agent is adopted to be used for preventing and treating potato late blight.The spraying of 200ga.i./ha thin up pressed by 40% Zhongshengmycin azoles mepanipyrim suspending agent, after medicine, the preventive effect of 7 days, 14 days is 86.2%, 80.1%, 10% Zhongshengmycin water dispersible granules presses 200ga.i./ha, 10% azoles mepanipyrim suspending agent by the spraying of 200ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 78.2%, 72.4% and 80.3%, 71.1%.Zhongshengmycin and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of potato late blight, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment five: 30% Zhongshengmycin azoles mepanipyrim dispersibles oil-suspending agent.
Zhongshengmycin 8%, azoles mepanipyrim 22%, lignosulfonates sodium 4%, polyoxyethylene polyoxypropylene base ether block copolymers 5%, methyl oleate 25%, organobentonite 8%, cocoa butter complements to 100%, pulverized in advance in proportion by above-mentioned formula, then add in sand mill and grind, after high shear mixing, the obtained 30% Zhongshengmycin azoles mepanipyrim of allotment dispersibles oil-suspending agent.
30% Zhongshengmycin azoles mepanipyrim is adopted to dispersible oil-suspending agent for preventing and treating downy mildew of lichee.30% Zhongshengmycin azoles mepanipyrim oil-suspending agent presses the spraying of 200mg/kg thin up, after medicine, the preventive effect of 7 days, 14 days is 90.4%, 83.3%, 10% Zhongshengmycin water dispersible granules presses 200mg./kg, 30% azoles mepanipyrim suspending agent by the spraying of 200mg/kg thin up, and after medicine, 7 days, 14 days preventive effects are respectively 80.3%, 70.3% and 81.4%, 68.3%.Zhongshengmycin and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of downy mildew of lichee, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment six: 60% Zhongshengmycin azoles mepanipyrim water dispersible granules.
Zhongshengmycin 5%, azoles mepanipyrim 55%, sodium lignin sulfonate 4%, polycarboxylic acids sodium 6%, glucose 5%, the withered powder 4% of tea, kaolin complements to 100%.By above-mentioned formula, 60% Zhongshengmycin azoles mepanipyrim water dispersible granules is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
60% Zhongshengmycin azoles mepanipyrim water dispersible granules is adopted to be used for preventing and treating downy mildew of garpe.60% Zhongshengmycin azoles mepanipyrim water dispersible granules presses the spraying of 200mg/kg thin up, after medicine, the preventive effect of 7 days, 14 days is 88.1%, 81.4%, 10% Zhongshengmycin water dispersible granules presses 200mg/kg, 30% azoles mepanipyrim water dispersible granules by the spraying of 200mg/kg thin up, and after medicine, 7 days, 14 days preventive effects are respectively 79.2%, 68.5% and 78.4%, 72.3%.Zhongshengmycin and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful of downy mildew of garpe, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Embodiment seven: 50% Zhongshengmycin azoles mepanipyrim wetting powder.
Zhongshengmycin 10%, azoles mepanipyrim 40%, lignosulfonates calcium 5%, sodium butylnaphthalenesulfonate 5%, white carbon 5%, kaolin complements to 100%.Mix entering in blender after above-mentioned formula in proportion coarse crushing, more namely obtain 50% Zhongshengmycin azoles mepanipyrim wetting powder after air-flow crushing.
Adopt 50% Zhongshengmycin azoles mepanipyrim wetting powder for preventing and treating sight tomato late blight.The spraying of 160ga.i./ha thin up pressed by 50% Zhongshengmycin azoles mepanipyrim wetting powder, after medicine, the preventive effect of 7 days, 14 days is 90.4%, 82.1%, 10% Zhongshengmycin wetting powder presses 160ga.i./ha, 30% azoles mepanipyrim water dispersible granules by the spraying of 160ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 82.4%, 71.1% and 81.5%, 70.3%.Zhongshengmycin and the composite rear synergistic effect of azoles mepanipyrim obvious, single dose is better than to the preventive effect successful seeing tomato late blight, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviates carrying capacity of environment, reduces use cost.
Claims (3)
1. one kind contains the bactericidal composition of Zhongshengmycin and azoles mepanipyrim, it is characterized in that: active ingredient is Zhongshengmycin and azoles mepanipyrim, Zhongshengmycin and azoles mepanipyrim ratio of weight and number are in the composition 30:1 ~ 1:30, and Zhongshengmycin and azoles mepanipyrim weight summation in the composition percentage by weight are 5% ~ 80%.
2. a kind of bactericidal composition containing Zhongshengmycin and azoles mepanipyrim according to claim 1, is characterized in that: described bactericidal composition processing can become suspending agent, dispersibles oil-suspending agent, water dispersible granules or wetting powder.
3. a kind of application of bactericidal composition in the crop downy mildew of preventing and treating to be caused by Peronosporales pathogen, epidemic disease containing Zhongshengmycin and azoles mepanipyrim as claimed in claim 1.
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| CN201510813017.3A CN105340928A (en) | 2015-11-20 | 2015-11-20 | Sterilization composition containing Zhongshengmycin and ametoctradin |
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| CN105340928A true CN105340928A (en) | 2016-02-24 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318622A (en) * | 2005-07-27 | 2012-01-18 | 巴斯夫欧洲公司 | Fungicidal mixture based on azoles and pyrimidine radicals amine |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318622A (en) * | 2005-07-27 | 2012-01-18 | 巴斯夫欧洲公司 | Fungicidal mixture based on azoles and pyrimidine radicals amine |
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Application publication date: 20160224 |