CN105327271A - 一种治疗婴幼儿黄疸的中药组合物 - Google Patents
一种治疗婴幼儿黄疸的中药组合物 Download PDFInfo
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Abstract
本发明一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈15—30、栀子6—9、黄连2—4、郁金12—15、白蔻5—7、香附15—30、苏梗7—11、金钱草25—35、满天星25—35、花斑竹25—35。本发明使用多味中草药配伍,成本低,配方合理,药效发挥地好,无副作用,具有清热除湿、利胆祛痰、泻火解毒、活血止痛、行气解郁、理气宽中等功效。主治婴幼儿黄疸。症见皮肤黄而鲜明,伴见发热、烦躁、啼哭、口渴、呕吐、尿黄、便秘等。经临床药效试验验证,本发明对婴幼儿黄疸的治愈率高达76%,总有效率接近100%。
Description
技术领域
本发明涉及中药组合物,具体地说是一种治疗婴幼儿黄疸的中药组合物。
背景技术
婴幼儿黄疸是体内胆红素浓度高的结果,而胆红素主要是红血球的代谢产物,当红血球老化破坏时,血红素就会游离出来,经代谢后产生胆红素。胆红素通过血液运送到肝脏,经肝脏的代谢后,由胆管***于肠子内。当上述的代谢路径发生问题,造成血中胆红素的堆积,就会形成黄疸。婴幼儿黄疸的症状一般表现为体温不正常、尿黄、食欲不佳、呕吐等,会严重影响因幼儿的生长发育。
目前婴幼儿黄疸可采用光疗治疗,又叫蓝光照射,此法为治标之法,不能治本;中医也有一些治疗黄疸的配方,但一般都是针对成人的,会对婴幼儿产生副作用。
发明内容
本发明所要解决的技术问题是提供一种成本低、无副作用、疗效显著的治疗婴幼儿黄疸的中药组合物。
为了解决上述技术问题,本发明采用如下技术方案:一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈15—30、栀子6—9、黄连2—4、郁金12—15、白蔻5—7、香附15—30、苏梗7—11、金钱草25—35、满天星25—35、花斑竹25—35。
优选的,各原料的重量份为:茵陈23、栀子8、黄连3、郁金13、白蔻6、香附22、苏梗9、金钱草30、满天星30、花斑竹30。
优选的,各原料的重量份为:茵陈15、栀子6、黄连2、郁金12、白蔻5、香附15、苏梗7、金钱草25、满天星25、花斑竹25。
优选的,各原料的重量份为:茵陈30、栀子9、黄连4、郁金15、白蔻7、香附30、苏梗11、金钱草35、满天星35、花斑竹35。
本发明治疗婴幼儿黄疸的中药组合物可以按传统中药方法煎煮成汤剂服用。
本发明还提供一种药物制剂,包括所述的治疗婴幼儿黄疸的中药组合物和药学上可接受的载体或赋形剂。对于本发明而言,要先将治疗婴幼儿黄疸的中药组合物经过本领域常规提取技术如水提纯沉降法或醇提水沉降法进行活性成分的提取,然后将活性成分与药学上可接受的载体或赋形剂结合,药学上可接受的载体或赋形剂根据不同的剂型而选择,所用的这些载体或赋形剂对于制药领域的普通技术人员是可以决定的。制成药物制剂可以方便患者服用。
优选的,所述药物制剂为颗粒剂、口服混悬剂或丸剂。
本发明中茵陈,味苦、辛,性微寒。归脾、胃、肝、胆经。有清利湿热,利胆退黄的功效。用于黄疸尿少,湿温暑湿,湿疮瘙痒。
栀子,味苦,性寒。归心、肺、三焦经。具有泻火除烦,清热利湿,凉血解毒的功效。用于热病心烦,湿热黄疸,淋证涩痛,血热吐衄,目赤肿痛,火毒疮疡,外治扭挫伤痛等症。
黄连,味苦,性寒。归心、脾、胃、肝、胆、大肠经。具有清热燥湿,泻火解毒的功效。主治湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,心悸不宁,血热吐衄,目赤,牙痛,消渴,痈肿疗疮;外治湿疹,湿疮,耳道流脓等症。
郁金,性辛、苦,寒。具有活血止痛、行气解郁、清心凉血、利胆退黄的功效。用于胸胁刺痛、胸痹心痛、经闭痛经、***胀痛、热病神昏、癫痫发狂、血热吐衄、黄疸尿赤等症。
白蔻,别名白蔻仁、豆蔻,具有化湿行气,温中止呕,开胃消食的功效。用于湿浊中阻,不思饮食,湿温初起,胸闷不饥,寒湿呕逆,胸腹胀痛,食积不消等症。
香附,味辛、微苦、微甘,性平。归肝、脾、三焦经。具有疏肝解郁,理气宽中,调经止痛的功效。用于肝郁气滞,胸胁胀痛,疝气疼痛,***胀痛,脾胃气滞,脘腹痞闷,胀满疼痛,***,经闭痛经等症。
苏梗,具有理气宽中,止痛,安胎的功效。用于胸膈痞闷,胃脘疼痛,嗳气呕吐,胎动不安等症。
金钱草,味甘、咸,性微寒。归肝、胆、肾、膀胱经。具有利湿退黄,利尿通淋,解毒消肿的功效。用于湿热黄疸,胆胀胁痛,石淋,热淋,小便涩痛,痈肿疔疮,蛇虫咬伤等症。
满天星,性平,味苦。具有清热利尿,化痰止咳的功效。用于急性黄疸型肝炎、急性肾炎、百日咳、***、脚癣、带状疱疹、结膜炎、丹毒等症。
花斑竹,具有祛风利湿,散瘀定痛,止咳化痰之功效。用于关节痹痛,湿热黄疸,经闭,癓瘕,咳嗽痰多,水火烫伤,跌扑损伤,痈肿疮毒等症。
本发明治疗婴幼儿黄疸的中药组合物的优点在于:
本发明使用多味中草药配伍,成本低,配方合理,药效发挥地好,无副作用,具有清热除湿、利胆祛痰、泻火解毒、活血止痛、行气解郁、理气宽中等功效。主治婴幼儿黄疸。症见皮肤黄而鲜明,伴见发热、烦躁、啼哭、口渴、呕吐、尿黄、便秘等。经临床药效试验验证,本发明对婴幼儿黄疸的治愈率高达76%,总有效率接近100%。
具体实施方式
下面结合实施例对本发明作进一步描述:
以下实施例所使用的各种原料,如未作特别说明,均为本领域公知的市售产品。
实施例1
一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈23g、栀子8g、黄连3g、郁金13g、白蔻6g、香附22g、苏梗9g、金钱草30g、满天星30g、花斑竹30g。
实施例2
一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈15g、栀子6g、黄连2g、郁金12g、白蔻5g、香附15g、苏梗7g、金钱草25g、满天星25g、花斑竹25g。
实施例3
一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈30g、栀子9g、黄连4g、郁金15g、白蔻7g、香附30g、苏梗11g、金钱草35g、满天星35g、花斑竹35g。
实施例4
临床药效试验
入选病例:经确诊为婴幼儿黄疸、有婴幼儿黄疸临床症状一项或多项的患者;
用法用量为:将一副治疗婴幼儿黄疸的中药组合物置于陶器中,加冷水至超过药物表面4—6cm,浸泡5—10min,然后用武火煮沸后,再以文火煎煮10min,将药液滤出,作为一剂,患者日服一剂,分四次服用,每隔四小时服用一次,3天为一个疗程,以实施例1至实施例3提供的配方作为1副药的用药剂量;
疗效情况判定标准:1.治愈。黄疸症状消失,复查时胆红素降至正常水平,血清谷丙转氨酶水平正常,其它不适症状完全消失,;2.有效。黄疸症状减轻,复查时胆红素和血清谷丙转氨酶水平较治疗前降低,其它不适症状减轻或部分消失;3.无效。黄疸症状未减轻,复查时胆红素和血清谷丙转氨酶水平较治疗前无变化或升高,其它不适症状无变化。
表1是300例婴幼儿黄疸患者的临床药效学报告。
表1
组别 | 服药人数 | 治愈人数 | 有效人数 | 无效人数 | 治愈率 | 总有效率 |
实施例1 | 100 | 76 | 23 | 1 | 76% | 99% |
实施例2 | 100 | 73 | 25 | 2 | 73% | 98% |
实施例3 | 100 | 74 | 23 | 3 | 74% | 97% |
典型病例如下:
云某,男,6个月。患者皮肤黄而鲜明,伴见发热、烦躁、啼哭,诊断为婴幼儿黄疸。服用本发明治疗婴幼儿黄疸的中药组合物,2个疗程后,发热消除,啼哭次数减少,继续服用,7个疗程后,痊愈,未见任何副作用,半年后随访无复发。
朱某,女,5个月。患者皮肤、粘膜黄染,伴低热、呕吐、腹胀,诊断为婴幼儿黄疸。服用本发明治疗婴幼儿黄疸的中药组合物,2个疗程后,低热消除,呕吐次数减少,腹胀减轻,继续服用,8个疗程后,痊愈,未见任何副作用,半年后随访无复发。
何某,男,1个月。患者皮肤发黄,肝脾肿大,伴低热、呕吐、大便色浅,诊断为婴幼儿黄疸。服用本发明治疗婴幼儿黄疸的中药组合物,2个疗程后,肝脾肿大有所改善,低热消除,呕吐次数减少,继续服用,7个疗程后,痊愈,未见任何副作用,半年后随访无复发。
施某,女,3个月。患者皮肤黄而鲜明,伴见发热、啼哭、呕吐、尿黄,诊断为婴幼儿黄疸。服用本发明治疗婴幼儿黄疸的中药组合物,2个疗程后,发热消除,啼哭、呕吐次数减少,尿黄改善,继续服用,8个疗程后,痊愈,未见任何副作用,半年后随访无复发。
方某,女,5个月。患者皮肤黄而鲜明,伴见发热、烦躁、啼哭、口渴、呕吐、尿黄、便秘,诊断为婴幼儿黄疸。服用本发明治疗婴幼儿黄疸的中药组合物,2个疗程后,发热消除,啼哭、呕吐次数减少,尿黄改善,继续服用,9个疗程后,痊愈,未见任何副作用,半年后随访无复发。
应当理解本文所述的例子和实施方式仅为了说明,本领域技术人员可根据它做出各种修改或变化,在不脱离本发明精神实质的情况下,都属于本发明的保护范围。
Claims (6)
1.一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈15—30、栀子6—9、黄连2—4、郁金12—15、白蔻5—7、香附15—30、苏梗7—11、金钱草25—35、满天星25—35、花斑竹25—35。
2.一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈23、栀子8、黄连3、郁金13、白蔻6、香附22、苏梗9、金钱草30、满天星30、花斑竹30。
3.一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈15、栀子6、黄连2、郁金12、白蔻5、香附15、苏梗7、金钱草25、满天星25、花斑竹25。
4.一种治疗婴幼儿黄疸的中药组合物,按重量份,包括以下原料:茵陈30、栀子9、黄连4、郁金15、白蔻7、香附30、苏梗11、金钱草35、满天星35、花斑竹35。
5.一种药物制剂,包括权利要求1所述的治疗婴幼儿黄疸的中药组合物和药学上可接受的载体或赋形剂。
6.如权利要求5所述的药物制剂,其特征在于:所述药物制剂为颗粒剂、口服混悬剂或丸剂。
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