CN105326936A - Traditional Chinese medicine composition for treating hypertension and hyperlipidemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hypertension and hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hypertension and hyperlipidemia and a preparation method thereof. The traditional Chinese medicine composition is prepared from 90-180 parts of folium apocyni veneti, 150-220 parts of the root of kudzu vine and 140-180 parts of hawthorn slices. The traditional Chinese medicine composition preparation is medicinal vinegar or tablets or particles or capsules. According to the traditional Chinese medicine composition, blood pressure is reduced through folium apocyni veneti, hawthorns and aged vinegar; blood fat is reduced through hawthorns and the aged vinegar; flavonoid constituents and puerarin of the root of kudzu vine are rich, so that plasma renin activity and angiotensin are remarkably reduced, and blood pressure is reduced. Thus, folium apocyni veneti, the root of kudzu vine and hawthorns are adopted as main raw materials, in addition, the aged vinegar is adopted as an ingredient added to enhance the efficacy of medicine to treat hypertension and hyperlipidemia, and the treatment effect of the traditional Chinese medicine composition is remarkable. The composition is used for treating hypertension and hyperlipidemia, the treatment effect is remarkable, safety and effectiveness are achieved, and the composition can be used for a long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly a kind of Chinese medicine composition for the treatment of hypertension, hyperlipemia and preparation method thereof.
Background technology
Hyperlipidemia refers to that blood lipid level is too high, directly can cause the disease of some serious harm healths, as atherosclerosis, coronary heart disease, pancreatitis etc.Hyperlipemia can be divided into constitutional and Secondary cases two class.Constitutional is relevant with heredity with congenital, due to single-gene defect or polygenes defect, make the receptor of the transhipment of participation lipoprotein and metabolism, enzyme or apolipoprotein caused by abnormal, or cause due to environmental factors (diet, nutrition, medicine) with by unknown mechanism.Secondary cases is multiple is born in metabolic disorder disease (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal cortex function are hyperfunction), or with other factor age, sex, season, drink, smoking, diet, physical exertion, psychentonia, emotional activity etc. be relevant.Previously think total cholesterol density of blood plasma >5.17mmol/L(200mg/dl) can hypercholesterolemia be decided to be, blood plasma triacylglycerol concentration >2.3mmol/L(200mg/dl) be hypertriglyceridemia.
Hypertension is clinical is defined as systolic pressure >=140, and diastolic pressure >=90 are vascular hypertension.Hypertension can be divided into two classes clinically: essential hypertension
(be a kind of with blood pressure rising for main clinical manifestation, and the not yet clear and definite independent disease of the cause of disease) and secondary hypertension
(be also called symptomatic hypertension, in this kind of disease, the cause of disease is clear and definite, and hypertension is only one of clinical manifestation of this kind of disease, blood pressure can temporary or persistency raise).
Hypertension, hyperlipemia is that a kind of person in middle and old age often send out disease, multiple disease, and both are often accompanied.This disease brings long-term misery and torment to patient and family members, as treatment causes the generation of cardio-cerebral diseases not in time, has a strong impact on quality of life.
The traditional Chinese medical science is thought, hypertension causes due to symptoms such as hyperactivity of YANG due to deficiency of YIN, QI and blood deficiency, phlegm and blood stasis, deficiency of kidney-essence, kidney yang virtual loss, Chong and Ren channel disorders; The hyperlipidemia traditional Chinese medical science is thought, has following reason: one, physiques and natural endowment father and mother are fat, greasiness since the childhood, and after growing up, body is more plump, and how not enough yang-energy is often, and body fluid cream fat defeatedization is slow, and it is too much to educate matter in blood.Or ferritic hyperactivity of YANG due to deficiency of YIN, esterified for educating, dissolve in blood, blood fat raises.Two, liking quiet dynamic or natural disposition less likes quiet, and greedy sleeping is moved less; Or limit because of Job, bend over the desk all day, sit few walk, human functional activity of vital energy loses in dredging smooth, and then the defeated cloth of body fluid is unfavorable for the stagnation of QI.Cream fat trans-utilization is too late, so that raw multiplex few, and in lithosomic body, in contamination blood, therefore blood fat raises.Three, the improper eating and drinking without temperance of diet, hyperingestion, or throw off restraint the rich sweet savoury of food, too much cream fat enters human body with diet, defeated cloth, transforms too late, and be detained in blood, thus blood fat raises.Chronic dietary is improper, or excessive drinking excessively, undermines taste, and strong fortune mistake department, causes diet not reforming, can not change precise and tiny in nutrition whole body, becomes raw fat on the contrary turbid, is mixed in blood, causes blood fat to raise.Four, emotional stimulation worry impairing spleen, dysfunction of the spleen in transportation, or depressed rage impairing the liver, liver is lost bar and reaches, functional activity of QI being not smooth, and the defeated cloth of cream fat transporting is not normal, and blood fat raises.Five, to quench one's thirst, edema, hypochondriac pain, jaundice, disease are long-pending etc. card more diabete basic pathogenesis to belong to the deficiency of YIN scorching, owing to disturbing in asthenic fire, polyphagia due to stomach-heat, the normal polydipsia polyphagia of patient, but diet is precise and tiny can not become fat and preserve, and the fat of human body is anti-molten is to the greatest extent cream, be mixed in blood, cause blood fat to raise.
The medicine of existing treatment hypertension, hyperlipemia is mainly chemicals, and more single, and treatment hypertension or treatment hyperlipidemia, the medicine of Papillary is less, and it is expensive, and long-term taking toxic and side effects is larger.Therefore, a kind of safe and effective medicine of simultaneously treating hypertension, hyperlipemia of urgent clinical needs.
Summary of the invention
The technical problem to be solved in the present invention is: provide a kind of safe and effective, can Chinese medicine composition for the treatment of hypertension, hyperlipemia and preparation method thereof simultaneously.The present composition is utilized to treat hypertension, hyperlipemia, evident in efficacy, safe and effective, can life-time service.
In order to solve the problem, the technical scheme that the present invention takes is:
The invention provides a kind of Chinese medicine composition for the treatment of hypertension, hyperlipemia, represent with weight portion, the raw material of described Chinese medicine composition consists of: Folium Apocyni Veneti 90 ~ 180 parts, Radix Puerariae 150 ~ 220 parts and Fructus Crataegi slice 140 ~ 180 parts.
According to the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, the raw material of described Chinese medicine composition consists of: Folium Apocyni Veneti 120 ~ 150 parts, Radix Puerariae 170 ~ 200 parts and Fructus Crataegi slice 150 ~ 170 parts.
A preparation method for the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, described preparation method is:
First take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of above-mentioned Chinese medicine composition, take three kinds of raw materials are added in old vinegar and soaks, soak 6 ~ 9 days at ambient temperature; Filter after immersion, the bottling of gained filtrate packaging.
According to the preparation method of the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, the ratio of both three kinds of raw material gross weights and old vinegar addition is 1g:3 ~ 8mL.
A preparation method for the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, described preparation method comprises the following steps:
A, first take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of above-mentioned Chinese medicine composition;
B, the Folium Apocyni Veneti taken by step a, Radix Puerariae and Fructus Crataegi slice add in the ethanol of mass percentage concentration 30 ~ 70% and carry out extraction twice; First time, when extracting, ethanol consumption was 6 ~ 8 times of three kinds of raw material gross weights, reflux, extract, 2 ~ 3 hours; When second time is extracted, ethanol consumption is 4 ~ 6 times of three kinds of raw material gross weights, reflux, extract, 1 ~ 2 hour; Twice gained extracting solution is merged after extracting;
C, by step b gained extracting solution decompression recycling ethanol, be then evaporated to paste; The relative density of gained thick paste is 1.25 ~ 1.35;
D, step c gained thick paste is carried out vacuum drying, after drying, obtain dry cream;
E, steps d got dry extract and pulverizes, conventionally make preparation.
According to the preparation method of the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, in steps d, during vacuum drying, vacuum is 0.08MPa, baking temperature is 70 ~ 90 DEG C, drying time is 10 ~ 14h.
According to the preparation method of the Chinese medicine composition of above-mentioned treatment hypertension, hyperlipemia, preparation described in step e is medicated vinegar, tablet, capsule or granule.
Fructus Crataegi slice of the present invention: be that medical material Fructus Crataegi is cut into lamellar, be Fructus Crataegi slice.
The old vinegar that the present invention adopts is Shanxi mature vinegar, for the solid fermentation such as Sorghum vulgare Pers., Fructus Hordei Vulgaris, Semen Pisi sativi, wheat bran, the paddy pool form, is aging in 5 years, meets GB19777-205, total acid >=5.00g/ml.
The present invention adopts old vinegar in Chinese medicine composition preparation method, and when taking preparation (as: tablet, capsule or granule), employing old vinegar is extra conductant ingredient.
the pharmacological action of the various crude drug of the present invention:
Folium Apocyni Veneti: this product is apocynaceae plant Radix Raphani fiber crops, sweet in the mouth, hardship are cool in nature; Return Liver Channel.There is suppressing the hyperactive liver calm the nerves, the effects such as clearing away heat and promoting diuresis; Commonly use and control dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria, hypertension, neurasthenia, the cards such as nephritis edema.
Pharmacological action: this product has hypotensive effect, cardiotonic, effect for reducing blood fat, diuresis, delaying senility function etc.Commonly use the diseases such as Hypertension, heart failure, edema clinically.
Radix Puerariae: this product is the dry root of legume pueraria lobata.Sweet in the mouth, pungent, cool in nature, return lung meridian, stomach warp.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the effects such as yang invigorating antidiarrheal; Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, the cards such as diarrhea due to hypofunction of the spleen.
The pharmacological action of this product: spasmolysis, hypoglycemic activity, hypotensive activity and diuresis etc.
Modern science is analyzed further and is shown: be rich in much 13 kinds of isoflavone like substance in Radix Puerariae, main component puerarin is wherein all effective in cure to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease; Radix Puerariae has antioxidation, can improve immunity of organisms; There is dual regulation to blood glucose and blood pressure, can microcirculation be improved, there is the function improving learning and memory, have antineoplastic action, the concentration of alcohol in blood can also be reduced, have antialcoholism action etc.
Fructus Crataegi: Fructus Crataegi is cut into lamellar, is Fructus Crataegi slice.Fructus Crataegi sour in the mouth, sweet, slightly warm in nature; Return spleen, stomach, Liver Channel.This product has appetite-stimulating indigestion-relieving, changes stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, effects such as circulation of qi promoting of reducing phlegm; Be usually used in carnivorous stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, the card such as discharging fresh blood stool.
Fructus Crataegi energy prevention and cure of cardiovascular disease, has blood vessel dilating, heart tonifying, increase coronary flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, vessel softening and diuresis and sedation.In addition, also have and prevent and treat arteriosclerosis, anti-aging, antitumaous effect.
Main containing flavonoid, oligomeric flavanoids, organic acid, trace element in Fructus Crataegi, in addition also containing compositions such as triterpenes, steroid and organic amines.In the last few years, Fructus Crataegi achieved major progress in blood fat reducing, blood pressure lowering, anti-brain blood and mechanism of action thereof.
In Chinese medicine composition of the present invention, adopt Folium Apocyni Veneti, Fructus Crataegi and old vinegar blood pressure lowering; Fructus Crataegi, old vinegar blood fat reducing, Radix Puerariae is rich in flavones ingredient and puerarin can make plasma renin activity and angiotensin significantly reduce, blood pressure drops.So with Folium Apocyni Veneti, Radix Puerariae and Fructus Crataegi for primary raw material, take old vinegar as extra conductant ingredient in addition, treat hyperlipidemia and hypertension, its therapeutic effect is remarkable.
positive beneficial effect of the present invention:
1, the preparation method feature of Chinese medicine composition of the present invention is that extraction time is short, uses ethanol effectively can extract flavonoid active ingredient in medical material Folium Apocyni Veneti, Radix Puerariae, Fructus Crataegi slice, is applicable to industrial-scale production.
2, in Chinese medicine composition of the present invention, the Folium Apocyni Veneti of employing, Fructus Crataegi and Radix Puerariae are all the Chinese medicine of the medicine-food two-purpose that Ministry of Public Health is announced, and old vinegar is food, therefore composition of medicine of the present invention can life-time service, safe and effective, do not have toxic and side effects.
3, two kinds of preparation methoies of the present invention are adopted to prepare pharmaceutical composition of the present invention, can active ingredient in more efficiently extraction Chinese crude drug.
4, the present composition is utilized to treat hypertension, hyperlipemia, evident in efficacy, safe and effective, can life-time service.
clinical statistics data:
The product treatment hypertension utilizing Chinese medicine composition of the present invention to prepare, the clinical data of hyperlipidemia indication:
In recent years, product of the present invention was through carrying out clinical treatment to 398 routine hypertension, hyperlipemic patients, and therapeutic effect gives sufficient confirmation.
398 routine patients, all choose at random, wherein hyperpietic 126 example, hyperlipemic patients 141 example, hypertension, hyperlipemia patient 131 example, every routine hyperpietic all has sphygomanometer to detect, hyperlipemic patients detects blood fat 8, observes treatment situation in treatment, after treatment through detecting.In 398 routine patients, more than 30 years that disease time is the longest, the shortest 5 months, male patient 220 example, female patient 178 example, 35 ~ 87 years old age.Treat through taking product of the present invention, wherein hyperpietic fully recover 106 example, effective 17 example, invalid 3 example, cure rate is up to 84%, and total effective rate reaches 97.6%; High blood value patient fully recovers 127 examples, effective effect 14 example, and cure rate is up to 90%, and total effective rate reaches 100%; Hypertension, hyperlipemia patient fully recovers 112 examples, and effective effect 15 example, invalid 4 examples, cure rate is up to 85.5%, and total effective rate reaches 96.9%.
Therapeutic Method: utilize the prescription of Chinese medicine composition of the present invention to allocate, and make medicated vinegar, capsule or tablet and take.
Medicated vinegar instructions of taking of the present invention: morning, noon and afternoon every day respectively take 20 ~ 30 milliliters; One after each meal.
The course for the treatment of: 30 days be a course for the treatment of, general 3 ~ 4 courses for the treatment of.
Curative effect judgment criteria:
Recovery from illness: after testing, blood pressure is qualified at range of normal value, the every laboratory indexes of blood fat.
Effective: patient's subjective symptoms takes a turn for the better, the every laboratory indexes of blood pressure, blood fat declines to a great extent with comparing before treatment.
Invalid: patient is conscious, and clinical symptoms is not improved, the every laboratory indexes of blood pressure, blood fat is with the last sample for the treatment of.
detailed description of the invention:
Set forth the present invention further below in conjunction with embodiment, but do not limit content of the present invention.
For improving herb resource utilization rate, reducing taking dose, the present invention specifies in conjunction with existing Chinese Pharmacopoeia, Traditional Chinese medical theory and modern medical material chemical composition, carried out following examples and clinical verification.
Embodiment 1:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 180g, Radix Puerariae 440g and this consumption of Fructus Crataegi slice 280g(is that Chinese medicine composition basic components of the present invention expands 2 times).
Embodiment 2:
The embodiment of the present invention 1 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
First take raw material Radix Raphani Folium Cannabis 180g, Radix Puerariae 440g and Fructus Crataegi slice 280g according to the ratio of Chinese medicine composition described in embodiment 1, take three kinds of raw materials are added in old vinegar 4500mL and soaks, soak 7 days at ambient temperature; Filter after immersion, gained filtrate 2280mL packs bottling.
Embodiment 3:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 360g, Radix Puerariae 300g and this consumption of Fructus Crataegi slice 360g(is that Chinese medicine composition basic components of the present invention expands 2 times).
Embodiment 4:
The embodiment of the present invention 3 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
First take raw material Radix Raphani Folium Cannabis 360g, Radix Puerariae 300g and Fructus Crataegi slice 360g according to the ratio of Chinese medicine composition described in embodiment 3, take three kinds of raw materials are added in old vinegar 5000mL and soaks, soak 7 days at ambient temperature; Filter after immersion, gained filtrate 2560mL packs bottling.
Embodiment 5:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 300g, Radix Puerariae 360g and this consumption of Fructus Crataegi slice 320g(is that Chinese medicine composition basic components of the present invention expands 2 times).
Embodiment 6:
The embodiment of the present invention 5 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
First take raw material Radix Raphani Folium Cannabis 300g, Radix Puerariae 360g and Fructus Crataegi slice 320g according to the ratio of Chinese medicine composition described in embodiment 5, take three kinds of raw materials are added in old vinegar 4500mL and soaks, soak 7 days at ambient temperature; Filter after immersion, gained filtrate 2150mL packs bottling.
Embodiment 7:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 900g, Radix Puerariae 1080g and this consumption of Fructus Crataegi slice 960g(is that Chinese medicine composition basic components of the present invention expands 6 times).
Embodiment 8:
The embodiment of the present invention 7 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
First take raw material Radix Raphani Folium Cannabis 900g, Radix Puerariae 1080g and Fructus Crataegi slice 960g according to the ratio of Chinese medicine composition described in embodiment 7, take three kinds of raw materials are added in old vinegar 13500mL and soaks, soak 7 days at ambient temperature; Filter after immersion, gained filtrate 6400mL packs bottling.
Embodiment 9:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 900g, Radix Puerariae 1080g and this consumption of Fructus Crataegi slice 1020g(is that Chinese medicine composition basic components of the present invention expands 6 times).
Embodiment 10:
The embodiment of the present invention 9 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
First take raw material Radix Raphani Folium Cannabis 900g, Radix Puerariae 1080g and Fructus Crataegi slice 1020g according to the ratio of Chinese medicine composition described in embodiment 9, take three kinds of raw materials are added in old vinegar 13500mL and soaks, soak 7 days at ambient temperature; Filter after immersion, gained filtrate 6380mL packs bottling.
Embodiment 11:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 900g, Radix Puerariae 1080g and this consumption of Fructus Crataegi slice 960g(is that Chinese medicine composition basic components of the present invention expands 6 times).
Embodiment 12:
The embodiment of the present invention 11 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
A, first take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of Chinese medicine composition described in embodiment 11;
B, the Folium Apocyni Veneti taken by step a, Radix Puerariae and Fructus Crataegi slice add in the ethanol of mass percentage concentration 61.5% and carry out extraction twice; First time, when extracting, ethanol consumption was 23520mL, reflux, extract, 2 hours; When second time is extracted, ethanol consumption is 11760mL, reflux, extract, 1 hour; Twice gained extracting solution is merged after extracting;
C, by step b gained extracting solution decompression recycling ethanol, be then evaporated to paste; The relative density of gained thick paste is 1.31;
D, step c gained thick paste carried out vacuum drying (vacuum be 0.08MPa, temperature be 80 DEG C, 12 hours drying times), obtaining dry cream 238.14g(after drying, to receive dry cream rate be 8.1%);
E, steps d got dry extract and pulverizes, add old vinegar 6300mL stirring and dissolving, filter and make medicated vinegar 6460mL.
Embodiment 13:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 800g, Radix Puerariae 1000g and this consumption of Fructus Crataegi slice 1050g(is that Chinese medicine composition basic components of the present invention expands about 6 times).
Embodiment 14:
The embodiment of the present invention 13 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
A, first take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of Chinese medicine composition described in embodiment 13;
B, the Folium Apocyni Veneti taken by step a, Radix Puerariae and Fructus Crataegi slice add in the ethanol of mass percentage concentration 55% and carry out extraction twice; First time, when extracting, ethanol consumption was 19950mL, reflux, extract, 2 hours; When second time is extracted, ethanol consumption is 14250mL, reflux, extract, 1 hour; Twice gained extracting solution is merged after extracting;
C, by step b gained extracting solution decompression recycling ethanol, be then evaporated to paste; The relative density of gained thick paste is 1.34;
D, step c gained thick paste carried out vacuum drying (vacuum be 0.08MPa, temperature be 80 DEG C, 12 hours drying times), obtaining dry cream 236.6g(after drying, to receive dry cream rate be 8.3%);
E, steps d got dry extract and pulverizes, add starch 260g, use 80% alcohol granulation, after drying, add 1.5g Pulvis Talci, 1.5g magnesium stearate, granulate, tabletting, obtained 1916, the heavy 0.25g of every sheet.
Embodiment 15:
The present invention treats the Chinese medicine composition of hypertension, hyperlipemia, represents with weight g, and the raw material of Chinese medicine composition consists of Folium Apocyni Veneti 900g, Radix Puerariae 900g and this consumption of Fructus Crataegi slice 900g(is that Chinese medicine composition basic components of the present invention expands 6 times).
Embodiment 16:
The embodiment of the present invention 15 treats the preparation method of the Chinese medicine composition of hypertension, hyperlipemia:
A, first take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of Chinese medicine composition described in embodiment 15;
B, the Folium Apocyni Veneti taken by step a, Radix Puerariae and Fructus Crataegi slice add in the ethanol of mass percentage concentration 50% and carry out extraction twice; First time, when extracting, ethanol consumption was 16200mL, reflux, extract, 2 hours; When second time is extracted, ethanol consumption is 16200mL, reflux, extract, 1 hour; Twice gained extracting solution is merged after extracting;
C, by step b gained extracting solution decompression recycling ethanol, be then evaporated to paste; The relative density of gained thick paste is 1.30;
D, step c gained thick paste carried out vacuum drying (vacuum be 0.08MPa, temperature be 80 DEG C, 12 hours drying times), obtaining dry cream 229.5g(after drying, to receive dry cream rate be 8.5%);
E, steps d got dry extract and pulverizes, add starch 270g, use 80% alcohol granulation, add 1.5g Pulvis Talci, 1.5g magnesium stearate after drying, granulate, incapsulate, obtained 923 capsules, every heavy 0.51g.
clinical model case:
Case 1: high mountain, man, 44 years old, people from Jinshui District, Zhengzhou, suffer from hyperlipidemia (hypertriglyceridemia) 8 years, multi-treatment was undesirable.When taking medicine of the present invention: triglyceride is 3.39mmol/L, dizzy, dizzy, uncomfortable in chest, inappetence, obesity, fatigue and weakness, take medicated vinegar of the present invention (obtained by embodiment 9 product), every day 3 times, each 20 ~ 25mL, take half an hour after meal, take January, blood fat recovers normal, triglyceride is 1.2mmol/L, mental attitude is as ordinary person, and brains is salubrious, energetic.To take before and after medicated vinegar of the present invention lipid examination index in table 1.
。
Subsequently, consolidate again and take medicated vinegar of the present invention one month, with repetition measurement later six months, blood fat keeps normal, and mental attitude is normal, and physical ability is normal.
Case 2:
Lee, female, 64 years old, Zhongyuan (Zhengzhou) people from district, suffer from hypertension 15 years, long-term multi-treatment is undesirable, take lethargy before medicine of the present invention, dizziness, dizzy, cardiopalmus, uncomfortable in chest, inappetence, obesity, fatigue and weakness, dyschesia, systolic pressure 172mmHg, diastolic pressure 108mmHg, belongs to moderate hypertension.Took the tablet (i.e. product prepared by the embodiment of the present invention 14) of medicine of the present invention afterwards, every day 3 times, each 6, take half an hour after meal, and with old vinegar 10 ~ 20mL for guiding drug, take next day, stool excretion is smooth and easy, take January, blood pressure recovers normal high level, systolic pressure 138mmHg, diastolic pressure 187mmHg, take 2 months, blood pressure recovers normal value, systolic pressure 124mmHg, diastolic pressure 86mmHg, take 3 months, systolic pressure 115mmHg, diastolic pressure 72mmHg, withdrawal, repetition measurement blood pressure after half a year, systolic pressure 123mmHg, diastolic pressure 79mmHg, to take before and after medicine of the present invention blood pressure Index for examination in table 2.
。
After this patient takes medicine of the present invention, spirit is as usual, and brains is salubrious, energetic.Follow up a case by regular visits to so far without recurrence, the mental status, defecate that all are normal.
Case 3:
Guo, man 62 years old, people from Yingyang, Zhengzhou, suffers from hyperlipidemia (hypercholesterolemia) 20 years, and suffer from hypertension 18 years, long-term multi-treatment, effect is all undesirable.Before taking medicine of the present invention, T-CHOL is 6.23mmol/L, systolic pressure 166mmHg, diastolic pressure 103mmHg, dizzy, dizzy, heaviness of the head as being covered, uncomfortable in chest, inappetence, numb limbs and tense tendons, fatigue and weakness.Take capsule product of the present invention (product namely prepared by the embodiment of the present invention 16), every day 3 times, each 3, take half an hour after meal, and with old vinegar 10 ~ 20mL for guiding drug.Take January, blood fat recovers normal, and T-CHOL is for being 4.67mmol/L; In Prehypertensive, systolic pressure 166mmHg, diastolic pressure 103mmHg, mental attitude is as ordinary person, and brains is salubrious, energetic.After treatment 2 months again, repetition measurement after drug withdrawal half a year, blood pressure blood fat is normal, not bounce-back.To take before and after medicine of the present invention blood fat and blood pressure Index for examination in table 3.
。
Case 4:
Wang, female, 71 years old, people from Huiji District, Zhengzhou, suffer from hypertension 30 years, long-term treatment is undesirable, take lethargy before medicine of the present invention, dizziness, dizzy, cardiopalmus, uncomfortable in chest, inappetence, fatigue and weakness, stool exceptional hardship, systolic pressure 183mmHg, diastolic pressure 112mmHg, belong to height hypertension.Took the tablet (i.e. product prepared by the embodiment of the present invention 14) of medicine of the present invention afterwards, every day 3 times, each 6, take half an hour after meal, and with old vinegar 10 ~ 20mL for guiding drug, take next day, stool excretion is smooth and easy, take January, blood pressure significantly declines, systolic pressure 162mmHg, diastolic pressure 107mmHg, take 2 months, blood pressure recovers normal high level, systolic pressure 138mmHg, diastolic pressure 95mmHg, take 3 months, blood pressure recovers normal value systolic pressure 118mmHg, diastolic pressure 84mmHg, withdrawal, repetition measurement blood pressure after half a year, systolic pressure 126mmHg, diastolic pressure 86mmHg, to take before and after medicine of the present invention blood pressure Index for examination in table 4.
。
After this patient takes medicine of the present invention, spirit is as usual, and brains is salubrious, energetic.Follow up a case by regular visits to so far without recurrence, the mental status, defecate that all are normal.
Case 5:
Wear certain, man 78 years old, people from Yingyang, Zhengzhou, suffer from hyperlipidemia (hypertriglyceridemia) 30 years, suffer from hypertension 35 years, long-term multi-treatment, effect is all undesirable.Before taking medicine of the present invention, hypertriglyceridemia is 4.52mmol/L, systolic pressure 186mmHg, diastolic pressure 115mmHg, dizzy, dizzy, heaviness of the head as being covered, uncomfortable in chest, inappetence, numb limbs and tense tendons, fatigue and weakness.Take medicated vinegar of the present invention (product namely prepared by the embodiment of the present invention 12), every day 3 times, each 30mL, takes after meal half an hour.Take March, hypertriglyceridemia is 0.90mmol/L; Blood pressure is normal, systolic pressure 126mmHg, diastolic pressure 185mmHg, and mental attitude is as ordinary person, and brains is salubrious, energetic.After treatment 1 month again, repetition measurement after drug withdrawal half a year, blood pressure blood fat is normal, not bounce-back.To take before and after medicine of the present invention blood fat and blood pressure Index for examination in table 5.
。
Claims (7)
1. treat a Chinese medicine composition for hypertension, hyperlipemia, it is characterized in that, represent with weight portion, the raw material of described Chinese medicine composition consists of: Folium Apocyni Veneti 90 ~ 180 parts, Radix Puerariae 150 ~ 220 parts and Fructus Crataegi slice 140 ~ 180 parts.
2. the Chinese medicine composition for the treatment of hypertension, hyperlipemia according to claim 1, is characterized in that, the raw material of described Chinese medicine composition consists of: Folium Apocyni Veneti 120 ~ 150 parts, Radix Puerariae 170 ~ 200 parts and Fructus Crataegi slice 150 ~ 170 parts.
3. treat a preparation method for the Chinese medicine composition of hypertension, hyperlipemia described in claim 1, it is characterized in that, described preparation method is:
First take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of Chinese medicine composition described in claim 1, take three kinds of raw materials are added in old vinegar and soaks, soak 6 ~ 9 days at ambient temperature; Filter after immersion, the bottling of gained filtrate packaging.
4. the preparation method of the Chinese medicine composition for the treatment of hypertension, hyperlipemia according to claim 3, is characterized in that: the ratio of both three kinds of raw material gross weights and old vinegar addition is 1g:3 ~ 8mL.
5. treat a preparation method for the Chinese medicine composition of hypertension, hyperlipemia described in claim 1, it is characterized in that, described preparation method comprises the following steps:
A, first take raw material Radix Raphani Folium Cannabis, Radix Puerariae and Fructus Crataegi slice according to the ratio of Chinese medicine composition described in claim 1;
B, the Folium Apocyni Veneti taken by step a, Radix Puerariae and Fructus Crataegi slice add in the ethanol of mass percentage concentration 30 ~ 70% and carry out extraction twice; First time, when extracting, ethanol consumption was 6 ~ 8 times of three kinds of raw material gross weights, reflux, extract, 2 ~ 3 hours; When second time is extracted, ethanol consumption is 4 ~ 6 times of three kinds of raw material gross weights, reflux, extract, 1 ~ 2 hour; Twice gained extracting solution is merged after extracting;
C, by step b gained extracting solution decompression recycling ethanol, be then evaporated to paste; The relative density of gained thick paste is 1.25 ~ 1.35;
D, step c gained thick paste is carried out vacuum drying, after drying, obtain dry cream;
E, steps d got dry extract and pulverizes, conventionally make preparation.
6. the preparation method of the Chinese medicine composition for the treatment of hypertension, hyperlipemia according to claim 5, is characterized in that: in steps d, during vacuum drying, vacuum is 0.08MPa, baking temperature is 70 ~ 90 DEG C, drying time is 10 ~ 14h.
7. the preparation method of the Chinese medicine composition for the treatment of hypertension, hyperlipemia according to claim 5, is characterized in that: preparation described in step e is medicated vinegar, tablet, capsule or granule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072506A (en) * | 2016-07-12 | 2016-11-09 | 董雪 | A kind of Folium Apocyni Veneti health-care paste and preparation method thereof |
| CN106389492A (en) * | 2016-12-21 | 2017-02-15 | 郑州莉迪亚医药科技有限公司 | Chinese and western medicine composition for treating hypertension and preparing method and application thereof |
| CN115137770A (en) * | 2022-07-18 | 2022-10-04 | 劲牌持正堂药业有限公司 | Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772208A (en) * | 2004-11-08 | 2006-05-17 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
| CN102870937A (en) * | 2012-10-30 | 2013-01-16 | 朱克兰 | Health-care tea and preparation method thereof |
-
2015
- 2015-12-04 CN CN201510878031.1A patent/CN105326936A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772208A (en) * | 2004-11-08 | 2006-05-17 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
| CN102870937A (en) * | 2012-10-30 | 2013-01-16 | 朱克兰 | Health-care tea and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 索建兰等: "抗高血压中药的研究进展", 《中国民族民间医药》 * |
| 黄世敏: "《轻松降血脂》", 31 March 2015, 金盾出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072506A (en) * | 2016-07-12 | 2016-11-09 | 董雪 | A kind of Folium Apocyni Veneti health-care paste and preparation method thereof |
| CN106389492A (en) * | 2016-12-21 | 2017-02-15 | 郑州莉迪亚医药科技有限公司 | Chinese and western medicine composition for treating hypertension and preparing method and application thereof |
| CN115137770A (en) * | 2022-07-18 | 2022-10-04 | 劲牌持正堂药业有限公司 | Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure |
| CN115137770B (en) * | 2022-07-18 | 2023-11-17 | 劲牌持正堂药业有限公司 | Preparation method of traditional Chinese medicine product with efficacy of reducing blood fat and blood pressure |
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Application publication date: 20160217 |