CN105310897A - Biological frost crack prevention hand cream and preparation method thereof - Google Patents
Biological frost crack prevention hand cream and preparation method thereof Download PDFInfo
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- CN105310897A CN105310897A CN201510730524.0A CN201510730524A CN105310897A CN 105310897 A CN105310897 A CN 105310897A CN 201510730524 A CN201510730524 A CN 201510730524A CN 105310897 A CN105310897 A CN 105310897A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The invention provides a biological frost crack prevention hand cream. The biological frost crack prevention hand cream comprises the following components in parts by weight: 10-20 parts of mycosporine-like amino acids, 40-60 parts of an emulsifier, 1-10 parts of an antioxidant and 10-15 parts of allantoin. The invention also provides a preparation method of the biological frost crack prevention hand cream. The biological frost crack prevention hand cream has the beneficial effects of no chemical irritation, UV protection and frost crack prevention.
Description
Technical field
The present invention relates to hand cream technical field.More particularly, the present invention relates to the biological frost-cracking-preventing hand cream with sun-proof and frost-cracking-preventing excellent specific property.
Background technology
When Ozone hole problem is day by day serious, the ultraviolet radiation (especially UVB) arriving ground and water body is more and more stronger.The effect of the ultraviolet radiation that all aquatiles all may be strengthened day by day, these effects comprise the change of the macromolecular substances such as protein and DNA structure, and the chronic suppression of reacting some key physiological and acute injury etc.So very serious for the skin injury be exposed to for a long time under intense ultraviolet irradiation, therefore, the nursing of opponent is also even more important, but existing in be all that chemosynthesis is in the majority mostly, the biological frost-cracking-preventing hand cream that pure natural damages less is very few.
Red wine and the benefit of yellow wine extraction thing to skin mainly contain: to the erosion of antiactive oxygen, maintain the complete of cell membrane and skin texture; Suppress collagen protein catabolic enzyme and other various catabolic enzymes, anti-skin ageing; Reduce the inflammatory response that skin irriate causes; Suppress TYR enzymatic activity, reduce melanin and generate, allow skin whitening; Maintain antiotasis, prevent blood capillary varicose, promote fat and the metabolism of saccharide, eliminate tangerine hull constitution phenomenon.
Summary of the invention
As the result of various extensive and careful research and experiment, the present inventor has been found that, when adding class mycetocyte element sample aminoacid containing specific anti-ultraviolet function and frost-cracking-preventing and allantoin in hand cream, described compound contributes to improving the uvioresistant of hand cream and the performance of frost-cracking-preventing.Based on this discovery, complete the present invention.
An object of the present invention is to solve at least the problems referred to above or defect, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide a kind of hand cream with anti-ultraviolet and frost-cracking-preventing function sample, and it by adding biological pure natural anti-ultraviolet composition and frost-cracking-preventing composition, for hands provides multiple protective, can prevent extraneous damage.
A further object of the invention is the method by extracting the biotic component in hand cream, improves the utilization rate containing various effective ingredient plant, better plays pure natural plant ingredients that is moist and protective effect to skin to obtain.
In order to realize according to these objects of the present invention and other advantage, provide a kind of biological frost-cracking-preventing hand cream, described hand cream comprises following component by weight: class mycetocyte element sample amino acid/11 0 ~ 20 part, emulsifying agent 40 ~ 60 parts, antioxidant 1 ~ 10 part, allantoin 10 ~ 15 parts.
Preferably, wherein, described antioxidant is at least one in Red wine extract and yellow wine extraction thing.
Preferably, wherein, described emulsifying agent is one or more in glyceryl monostearate, isopropyl palmitate and glyceride.
Preferably, wherein, described biological frost-cracking-preventing hand cream comprises by weight: 20 parts, class mycetocyte element sample aminoacid, emulsifying agent 50 parts, antioxidant 10 parts, allantoin 15 parts.
Object of the present invention still further provides the preparation method of biological frost-cracking-preventing hand cream, and this preparation method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
The extraction of step 2, allantoin: choose the extraction source of Radix Betae as allantoin, allantoin is extracted, specifically comprise: adopt the allantoin active component of Subcritical water chromotagraphy technique to Radix Betae to carry out extraction and obtain allantoin extracting solution, adopted by described allantoin extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain allantoin viscous liquid, wherein, the Extracting temperature of described subcritical alcohol extraction process is 135 ~ 145 DEG C, extraction time is 48 ~ 50min, and liquid ratio is (13 ~ 15): 1;
The preparation of step 3, Red wine extract or yellow wine extraction thing: red wine or yellow wine are heated to 90 ~ 100 DEG C of evaporations, ethanol is volatilized clean, adopt rotary evaporator to rotate evaporate to dryness and obtain concentrate, the alcoholic solution of 97% of 4.5 ~ 5.5 times of volumes is added in described concentrate, by the polysaccharide compound precipitation in red wine or yellow wine, leave standstill 1.5 ~ 3.5h, vacuum filtration, vacuum lyophilization filtrate obtains Red wine extract or yellow wine extraction thing;
Step 4, the preparation of biological frost-cracking-preventing hand cream: select glyceryl monostearate, one or more in isopropyl palmitate and glyceride are as emulsifying agent, class mycetocyte element sample amino acid/11 0 ~ 20 weight portion that described step one is obtained, dissolve after allantoin 10 ~ 15 weight portion that described step 2 obtains and the Red wine extract obtained of described step 3 or the mixing of yellow wine extraction thing 1 ~ 10 weight portion, add emulsifying agent described in 40 ~ 60 weight portions wherein, 85 ~ 90 DEG C are heated under stirring, add in blender and stir, stir speed (S.S.) is 4000 ~ 5000 revs/min, stir 5 ~ 10min, be cooled to room temperature, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological frost-cracking-preventing hand cream.
Preferably, wherein, in described step 2, the Extracting temperature of described subcritical alcohol extraction process is 140 DEG C, and extraction time is 50min, and liquid ratio is 14: 1.
Preferably, wherein, in described step 3, the baking temperature of vacuum lyophilization is-20 ~-30 DEG C, and drying time is 15 ~ 18h.
Preferably, wherein, what the ultramicronising in described step 4 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
The present invention at least comprises following beneficial effect: hand cream compositions of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in traditional hand cream, adopt Pure natural cosmetic composition, therefore, it is possible to effectively protect hand, adopt biological anti-ultraviolet composition and frost-cracking-preventing composition, total care has been carried out to hand; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising is carried out to the hand cream formed, hand can be absorbed better.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
The present invention is described in further detail below, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
< example 1 >
A kind of biological frost-cracking-preventing hand cream, described hand cream comprises following component by weight: 20 parts, class mycetocyte element sample aminoacid, emulsifying agent 50 parts, antioxidant 10 parts, allantoin 15 parts.
Wherein, described antioxidant is Red wine extract, and described emulsifying agent is glyceryl monostearate.
The preparation method of above-mentioned biological frost-cracking-preventing hand cream comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
The extraction of step 2, allantoin: choose the extraction source of Radix Betae as allantoin, allantoin is extracted, specifically comprise: adopt the allantoin active component of Subcritical water chromotagraphy technique to Radix Betae to carry out extraction and obtain allantoin extracting solution, adopted by described allantoin extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain allantoin viscous liquid, wherein, the Extracting temperature of described subcritical alcohol extraction process is 140 DEG C, and extraction time is 50min, and liquid ratio is 14: 1;
The preparation of step 3, Red wine extract: red wine is heated to 90 ~ 100 DEG C of evaporations, ethanol is volatilized clean, adopt rotary evaporator to rotate evaporate to dryness and obtain concentrate, in described concentrate, add the alcoholic solution of 97% of 4.5 ~ 5.5 times of volumes, by the polysaccharide compound precipitation in red wine or yellow wine, leave standstill 1.5 ~ 3.5h, vacuum filtration, vacuum lyophilization filtrate obtains Red wine extract, and the baking temperature of vacuum lyophilization is-25 DEG C, and drying time is 16h;
Step 4, the preparation of biological frost-cracking-preventing hand cream: select glyceryl monostearate as emulsifying agent, class mycetocyte element sample aminoacid 20 weight portion that described step one is obtained, dissolve after Red wine extract 10 weight portion obtained mixing of allantoin 15 weight portion that described step 2 obtains and described step 3, add emulsifying agent described in 50 weight portions wherein, 85 ~ 90 DEG C are heated under stirring, add in blender and stir, stir speed (S.S.) is 4000 ~ 5000 revs/min, stir 5 ~ 10min, be cooled to room temperature, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological frost-cracking-preventing hand cream, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 160MPa, operating temperature is 25 DEG C.
Obtained biological frost-cracking-preventing hand cream is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 2 >
A kind of biological frost-cracking-preventing hand cream, described expansion hands frost comprises following component by weight: class mycetocyte element sample amino acid/11 0 part, emulsifying agent 40 parts, antioxidant 1 part, allantoin 10 parts.
Wherein, described antioxidant is yellow wine extraction thing, and described emulsifying agent is the mixture of isopropyl palmitate and glyceride.
The preparation method of biological frost-cracking-preventing hand cream, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
The extraction of step 2, allantoin: choose the extraction source of Radix Betae as allantoin, allantoin is extracted, specifically comprise: adopt the allantoin active component of Subcritical water chromotagraphy technique to Radix Betae to carry out extraction and obtain allantoin extracting solution, adopted by described allantoin extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain allantoin viscous liquid, wherein, the Extracting temperature of described subcritical alcohol extraction process is 135 DEG C, and extraction time is 50min, and liquid ratio is 13: 1;
The preparation of step 3, yellow wine extraction thing: yellow wine is heated to 90 ~ 100 DEG C of evaporations, ethanol is volatilized clean, adopt rotary evaporator to rotate evaporate to dryness and obtain concentrate, in described concentrate, add the alcoholic solution of 97% of 4.5 ~ 5.5 times of volumes, by the polysaccharide compound precipitation in yellow wine, leave standstill 1.5 ~ 3.5h, vacuum filtration, vacuum lyophilization filtrate obtains yellow wine extraction thing, wherein, the baking temperature of vacuum lyophilization is-30 DEG C, and drying time is 15h;
Step 4, the preparation of biological frost-cracking-preventing hand cream: select isopropyl palmitate and glyceride mixture as emulsifying agent, class mycetocyte element sample amino acid/11 0 weight portion that described step one is obtained, dissolve after yellow wine extraction thing 1 weight portion obtained mixing of allantoin 10 weight portion that described step 2 obtains and described step 3, add emulsifying agent described in 40 weight portions wherein, 85 ~ 90 DEG C are heated under stirring, add in blender and stir, stir speed (S.S.) is 4000 ~ 5000 revs/min, stir 5 ~ 10min, be cooled to room temperature, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological frost-cracking-preventing expansion hands frost, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 150MPa, operating temperature is 20 DEG C.
Obtained biological frost-cracking-preventing hand cream is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
< example 3 >
A kind of biological frost-cracking-preventing hand cream, described hand cream comprises following component by weight: 20 parts, class mycetocyte element sample aminoacid, emulsifying agent 60 parts, antioxidant 10 parts, allantoin 15 parts.
Wherein, described antioxidant is the mixture of Red wine extract and yellow wine extraction thing; Described emulsifying agent is the mixture of glyceryl monostearate, isopropyl palmitate and glyceride.
The preparation method of biological frost-cracking-preventing hand cream, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
The extraction of step 2, allantoin: choose the extraction source of Radix Betae as allantoin, allantoin is extracted, specifically comprise: adopt the allantoin active component of Subcritical water chromotagraphy technique to Radix Betae to carry out extraction and obtain allantoin extracting solution, adopted by described allantoin extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain allantoin viscous liquid, wherein, the Extracting temperature of described subcritical alcohol extraction process is 145 DEG C, and extraction time is 48min, and liquid ratio is 15: 1;
The preparation of step 3, Red wine extract or yellow wine extraction thing: red wine or yellow wine are heated to 90 ~ 100 DEG C of evaporations, ethanol is volatilized clean, adopt rotary evaporator to rotate evaporate to dryness and obtain concentrate, the alcoholic solution of 97% of 4.5 ~ 5.5 times of volumes is added in described concentrate, by the polysaccharide compound precipitation in red wine or yellow wine, leave standstill 1.5 ~ 3.5h, vacuum filtration, vacuum lyophilization filtrate obtains Red wine extract or yellow wine extraction thing, wherein, the baking temperature of vacuum lyophilization is-30 DEG C, and drying time is 15h;
Step 4, the preparation of biological frost-cracking-preventing hand cream: select glyceryl monostearate, one or more in isopropyl palmitate and glyceride are as emulsifying agent, class mycetocyte element sample aminoacid 20 weight portion that described step one is obtained, dissolve after allantoin 15 weight portion that described step 2 obtains and the Red wine extract obtained of described step 3 or the mixing of yellow wine extraction thing 10 weight portion, add emulsifying agent described in 60 weight portions wherein, 85 ~ 90 DEG C are heated under stirring, add in blender and stir, stir speed (S.S.) is 4000 ~ 5000 revs/min, stir 5 ~ 10min, be cooled to room temperature, carry out ultramicronising by dry pulverization process technology or waterproof pulverization technology and obtain biological frost-cracking-preventing hand cream, wherein, what ultramicronising adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shear, fragmentation and homogenizing, wherein operating pressure is 180MPa, operating temperature is 25 DEG C.
Obtained biological frost-cracking-preventing hand cream is through system destructive testing, and to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
Visible, hand cream compositions of the present invention overcomes a large amount of interpolation harsh chemicals and defect that is carcinogenic or toxic chemical in traditional hand cream, adopt Pure natural cosmetic composition, therefore, it is possible to effectively protect hand, adopt biological anti-ultraviolet composition and frost-cracking-preventing composition, total care has been carried out to hand; Owing to taking, active component extracting method is carried out to the pure natural plant containing effective ingredient, therefore, it is possible to improve the utilization rate of plant, without adding any toxic chemical solvent in whole leaching process, and ultramicronising has been carried out to the hand cream formed, hand can be absorbed better, the biological frost-cracking-preventing hand cream that the present invention obtains is through system destructive testing, to skin without any damage, and the every sense index of product, physical and chemical index, sanitary index all meet corresponding national standard.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (8)
1. a biological frost-cracking-preventing hand cream, described hand cream comprises following component by weight: class mycetocyte element sample amino acid/11 0 ~ 20 part, emulsifying agent 40 ~ 60 parts, antioxidant 1 ~ 10 part, allantoin 10 ~ 15 parts.
2. biological frost-cracking-preventing hand cream as claimed in claim 1, wherein, described antioxidant is at least one in Red wine extract and yellow wine extraction thing.
3. biological frost-cracking-preventing hand cream as claimed in claim 2, wherein, described emulsifying agent is one or more in glyceryl monostearate, isopropyl palmitate and glyceride.
4. biological frost-cracking-preventing hand cream as claimed in claim 1, wherein, described biological frost-cracking-preventing hand cream comprises by weight: 20 parts, class mycetocyte element sample aminoacid, emulsifying agent 50 parts, antioxidant 10 parts, allantoin 15 parts.
5. a preparation method for biological frost-cracking-preventing hand cream, described method comprises:
The amino acid whose extraction of step one, class mycetocyte element sample: first, choose Thallus Porphyrae as the amino acid whose extraction source of class mycetocyte element sample, the silt in cleaning Thallus Porphyrae, in vacuum freeze drier, carry out drying, baking temperature is-10 ~-30 DEG C, and drying time is 15 ~ 20h; Secondly, get dried Thallus Porphyrae 10g, be dissolved in the methanol of 500mL, 2 ~ 2.5h is heated with 50 ~ 60 DEG C, cooling, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, filter, add wherein in the dichloromethane of 800mL, high speed centrifugation, centrifugal rotating speed is 3000 ~ 3500 revs/min, time is 5 ~ 6min, obtains transparent supernatant, when noble gas, evaporative removal solvent, the deionized water dissolving adding 50mL is prepared into high performance liquid chromatography sample; Finally, carry out high performance liquid chromatography separation and draw pure class mycetocyte element sample aminoacid, wherein, high performance liquid chromatography separation condition is: column temperature is 30 DEG C, mobile phase is 0.2% glacial acetic acid aqueous solution, and flow velocity is 0.5mL/min, and mensuration wavelength is 330nm, sample size is 20 μ L, and sample introduction analysis time is 30min;
The extraction of step 2, allantoin: choose the extraction source of Radix Betae as allantoin, allantoin is extracted, specifically comprise: adopt the allantoin active component of Subcritical water chromotagraphy technique to Radix Betae to carry out extraction and obtain allantoin extracting solution, adopted by described allantoin extracting solution vacuum rotary evaporator to rotate evaporate to dryness and obtain allantoin viscous liquid, wherein, the Extracting temperature of described subcritical alcohol extraction process is 135 ~ 145 DEG C, extraction time is 48 ~ 50min, and liquid ratio is (13 ~ 15): 1;
The preparation of step 3, Red wine extract or yellow wine extraction thing: red wine or yellow wine are heated to 90 ~ 100 DEG C of evaporations, ethanol is volatilized clean, adopt rotary evaporator to rotate evaporate to dryness and obtain concentrate, the alcoholic solution of 97% of 4.5 ~ 5.5 times of volumes is added in described concentrate, by the polysaccharide compound precipitation in red wine or yellow wine, leave standstill 1.5 ~ 3.5h, vacuum filtration, vacuum lyophilization filtrate obtains Red wine extract or yellow wine extraction thing;
Step 4, the preparation of biological frost-cracking-preventing hand cream: select glyceryl monostearate, one or more in isopropyl palmitate and glyceride are as emulsifying agent, class mycetocyte element sample amino acid/11 0 ~ 20 weight portion that described step one is obtained, dissolve after allantoin 10 ~ 15 weight portion that described step 2 obtains and the Red wine extract obtained of described step 3 or the mixing of yellow wine extraction thing 1 ~ 10 weight portion, add emulsifying agent described in 40 ~ 60 weight portions wherein, 85 ~ 90 DEG C are heated under stirring, add in blender and stir, stir speed (S.S.) is 4000 ~ 5000 revs/min, stir 5 ~ 10min, be cooled to room temperature, biological frost-cracking-preventing hand cream is obtained by carrying out ultramicronising in method crushing technology or waterproof pulverization technology.
6. the preparation method of biological frost-cracking-preventing hand cream as claimed in claim 5, wherein, in described step 2, the Extracting temperature of described subcritical alcohol extraction process is 140 DEG C, and extraction time is 50min, and liquid ratio is 14: 1.
7. the preparation method of biological frost-cracking-preventing hand cream as claimed in claim 5, wherein, in described step 3, the baking temperature of vacuum lyophilization is-20 ~-30 DEG C, and drying time is 15 ~ 18h.
8. the preparation method of biological frost-cracking-preventing hand cream as claimed in claim 5, wherein, what the ultramicronising in described step 4 adopted is dynamic high-pressure microjet ultramicronising technology, concrete steps: shearing, broken and homogenizing, wherein operating pressure is 150 ~ 180MPa, and operating temperature is 20 ~ 25 DEG C.
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