CN105286006A - Pure grape essence ferment and production method thereof - Google Patents
Pure grape essence ferment and production method thereof Download PDFInfo
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- CN105286006A CN105286006A CN201510577382.9A CN201510577382A CN105286006A CN 105286006 A CN105286006 A CN 105286006A CN 201510577382 A CN201510577382 A CN 201510577382A CN 105286006 A CN105286006 A CN 105286006A
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Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses pure grape essence ferment and a production method thereof. The pure grape essence ferment consists of the following raw materials in parts by weight: 50-90 parts of fresh grapes, 0-5 parts of nonfat grape skin residue powder, 0-2 parts of grape wine, 0-5 parts of high fructose corn syrup, 0-100 parts of white granulated sugar, 0-2 parts of xylooligosaccharide, 0-35 parts of L-arabinose, 0-10 parts of sugar alcohol, and an appropriate quantity of probiotics. The production method comprises the following steps of: cleaning the fresh grapes, removing stems of the cleaned fresh grapes, crushing the fresh grapes without stems, squeezing juice from the crushed grapes, adding water to grape skin residues, grinding the grape skin residues, adding pectinase, cellulase, and neutral protease, and performing enzymolysis; and enabling the probiotics to be fermented when being subjected to heat preservation, after fermenting the fermented probiotics, and performing centrifugation to remove residues so as to obtain raw pure grape essence ferment liquid. The pure grape essence ferment disclosed by the invention has the efficacies of reducing blood lipid, reducing weight, improving the antioxidant ability of organisms, regulating and balancing intestinal flora, improving immunity, resisting oxidation, promoting the beautifying of the features, promoting sleep, and delaying senescence.
Description
Technical field
The invention belongs to food processing field, specifically relate to a kind of grape elite ferment and production method thereof.
Background technology
Containing glucose, fructose in grape fruit, a small amount of sucrose, wood sugar, single glycoside of tartaric acid, oxalic acid, citric acid, malic acid, Red Wine Polyphenols, kind anthocyanidin and two glycoside, Jiao's property catechol, gallo catechin, gallate etc.Every 100 grams contain 0.2 gram, protein, calcium 4 milligrams, 15 milligrams, phosphorus, iron 0.6 milligram, carrotene 0.04 milligram, thiamine 0.04 milligram, 0.01 milligram, riboflavin, niacin 0.1 milligram, vitamin C 4 milligrams.Containing containing abundant anthocyanidin in Grape Skin, there are Cyanidin, peonidin, delphinidin, petunidin, malvidin, malvidin-3-β-glycoside.Oil content 9.58% in seed.
Grape sugar content up to 10% ~ 30%, based on glucose.Volume tartaric acid in grape contributes to digestion, suitably eats a little grape more, can strengthening the spleen and stomach.Containing mineral calcium, potassium, phosphorus, iron, glucose, fructose, protein, tartaric acid and multivitamin B1, B2, B6, C, P etc. in grape, amino acid also containing multiple needed by human body, normal food grape is of great advantage to neurasthenia, excessive fatigue, and it is also containing the multiple material with physiological function in addition.After grape is made raisins, sugar can be relative high with the content of iron, is the excellent tonic product of women, children and weak anaemia person.
The flavonoids contained in grape is a kind of powerful antioxidants, can be anti-ageing, and can remove interior free yl.Containing a kind of anticancer trace element (resveratrol) in grape, healthy cell canceration can be prevented, stop cancer cell diffusion.
French scientist research finds, grape can stop thrombosis better than aspirin, and can reduce human serum cholesterol levels, reduces hematoblastic cohesiveness, has certain effect to prevention cardiovascular and cerebrovascular diseases.The traditional Chinese medical science is thought, the flat taste of grape is sweet, and energy nourish liver and kidney, born fluid, strengthening the bones and muscles, have the effect of tonifying Qi and blood, tonneau urine, can be used for the supplemental treatment of the illnesss such as deficiency of the spleen causing weakness of QI, shortness of breath and fatigue, oedema, difficult urination.
Grape pip is rich in a kind of nutriment " polyphenol ", for a long time, people believe that vitamin E and vitamin C are the most effective anti-ageing two kinds of materials always, but the particular matter of this polyphenol contained in grape pip, its antidotal ability is 50 times of vitamin E, is ascorbic 25 times.Conventional take grape pip as skin care item or the food of raw material, can improve looks, delay senility, make the pure white exquisiteness of skin, high resilience.Can say, grape whole body is all precious.
Prior art does not well utilize grape resource, especially grape pip and Grape Skin, not for the feature development brewage process of grape material, does not also utilize wine brewing residue grape skin to produce the precedent of grape elite ferment.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide that a kind of raw material availability is high, nutritive value is comprehensive, health-care effect significantly, the low pure grape elite ferment of rational technology, production cost and production method thereof.
Technical scheme of the present invention is: a kind of pure grape elite ferment, it is characterized in that its raw material consists of according to weight portion: new fresh grape 50-90 part, degreasing Grape Skin ground-slag 0-5 part, grape wine 0-2 part, HFCS 0-5 part, white granulated sugar 0-100 part, xylo-oligosaccharide 0-2 part, Arabinose 0-35 part, sugar alcohol 0-10 part, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase at 45-50 DEG C of enzymolysis 2-3 hour, then add sterilizing after HFCS, grape wine;
2) step 1) grape skin that obtains adds 5-10 times of water mill slurry, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1-2 hour, then 55 DEG C are heated to, add the neutral proteinase of 0.1-0.3% (dry), stir, be incubated heat sterilization after 2-3 hour, be cooled to 30-40 DEG C, inoculation probio heat-preservation fermentation 36-48 hour;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 20-30 DEG C of heat-preservation fermentation, when zymotic fluid ph value reaches 3.0-4.0 or natural termination fermentation, be cooled to 15-20 DEG C and continue the rear ferment 30-90 days of insulation, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, bottling sterilization obtains pure grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain pure grape elite ferment.
Described rear ferment is natural aeration two hours at ambient temperature, then sealed fermenting 30-90 days.
Described degreasing Grape Skin ground-slag is grape skin gained after drying, pulverize, squeezing de-oiling of wine brewing gained.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Polydextrose can be added in pure grape elite ferment stoste, l-cn makes the ferment with weight-reducing effect.
Pure grape elite ferment after allotment is made pure grape elite ferment powder through concentrate drying, pulverizing, allotment.
The sugar alcohol that pure grape elite ferment adds noenergy replaces HFCS and white granulated sugar.
Probio is not toxigenic bacterial strain that state approval can be used for food or medicine.
Invention achieves following effect:
Achieve the comprehensive utilization of grape resource, do not produce discarded object, effectively can also utilize the grape skin that grape wine or grape juice produce.
Grape skin slurries, through probiotics fermention, make the fiber in grape skin, polysaccharide, protein molecular structure change, and based on Small molecular, not only nutritive effect increases, and is more conducive to the stripping of anthocyanidin, Flavonoid substances, eliminates the bitter taste of grape skin.
Probio during the fermentation, due to microorganism, to promote raw material metabolism to produce a large amount of elementary, secondary metabolite is as amino acid, vitamin, organic acid, various enzyme, aromatic compound, sugar alcohol, polyphenol, polysaccharide, outside the organic active ingredients such as small-molecular peptides and a large amount of compound sugar, but also produce a large amount of probiotic cells, hepatocuprein (SOD), eicosapentaenoic acid (EPA), the many valuable factor that DHA (DHA) and flavone compound etc. are with health role to the mankind, these beneficiating ingredients promote the increment of intestinal beneficial flora greatly, suppress harmful bacteria, thus reduce the generation of corrupt substance and noxious material, playing functional while, also play regulating intestinal canal colony balance, strengthen immunity, promote beauty treatment, promote sleep, the effect delayed senility.
The present invention, due to the biochemical reaction of raw material enzymolysis processing and multi-strain fermentation, makes the Flavonoid substances in raw material, anthocyanidin etc. and fibr tissue and Protein Separation, in free state, is conducive to human body and better absorbs.
Of the present invention containing abundant soluble dietary fiber, compound sugar, containing a large amount of probios, product is made to have whole intestines defaecation, the endotoxic good effects of purged body, long-term edible can reach lowering blood-fat and reducing weight, toxin expelling, anti-oxidant, skin whitening, beauty treatment, control colorectal cancer, the medical value of control heart disease and health-care effect.
With specific embodiment, technical scheme of the present invention is described further below.
Detailed description of the invention
Embodiment 1
A kind of pure grape elite ferment, its raw material consists of according to weight portion: new fresh grape 90 parts, degreasing Grape Skin ground-slag 5 parts, grape wine 2 parts, HFCS 5 parts, white granulated sugar 100 parts, xylo-oligosaccharide 2 parts, Arabinose 35 parts, sugar alcohol 10 parts, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add the pectase of 300ppm and cellulase 50 DEG C of enzymolysis 3 hours, then add sterilizing after HFCS, grape wine;
2) step 1) grape skin that obtains adds 10 times of water mills slurries, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and the cellulase of 200ppm, enzymolysis 2 hours, then 55 DEG C are heated to, add the neutral proteinase of 0.3% (dry), stir, be incubated heat sterilization after 3 hours, be cooled to 40 DEG C, inoculation probio heat-preservation fermentation 48 hours;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 30 DEG C of heat-preservation fermentations, when zymotic fluid ph value reaches 3.0, be cooled to 20 DEG C and continue after insulation ferment 90 days, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, 85 pasteurizes of bottling obtain pure grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain pure grape elite ferment.
Degreasing Grape Skin ground-slag is grape skin gained after drying, pulverize, squeezing de-oiling of wine brewing gained.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Embodiment 2
A kind of pure grape elite ferment, is characterized in that its raw material consists of according to weight portion: new fresh grape 50 parts, degreasing Grape Skin ground-slag 0 part, grape wine 0 part, HFCS 0 part, white granulated sugar 0 part, xylo-oligosaccharide 0 part, Arabinose 0 part, sugar alcohol 10 parts, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase 45 DEG C of enzymolysis 2 hours, then sterilizing;
2) step 1) grape skin that obtains adds 5 times of water mills slurries, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1 hour, then 55 DEG C are heated to, add the neutral proteinase of 0.1% (dry), stir, be incubated heat sterilization after 2 hours, be cooled to 30 DEG C, inoculation probio heat-preservation fermentation 36 hours;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 20 DEG C of heat-preservation fermentations, when zymotic fluid ph value reaches 4.0, be cooled to 15 DEG C and continue after insulation ferment 30 days, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add sugar alcohol in pure grape elite ferment stoste, bottling sterilization obtains pure grape elite ferment;
5) add sugar alcohol in pure grape elite ferment stoste, bottle and obtain pure grape elite ferment.
Described rear ferment is natural aeration two hours at ambient temperature, then sealed fermenting 30-90 days.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Embodiment 3
A kind of pure grape elite ferment, is characterized in that its raw material consists of according to weight portion: new fresh grape 70 parts, degreasing Grape Skin ground-slag 2.5 parts, grape wine 1 part, HFCS 2.5 parts, white granulated sugar 100 parts, xylo-oligosaccharide 1 part, Arabinose 35 parts, sugar alcohol 5 parts, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase at 48 DEG C of enzymolysis 2-3 hour, then add sterilizing after HFCS, grape wine;
2) step 1) grape skin that obtains adds 5-10 times of water mill slurry, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1.5 hours, then 55 DEG C are heated to, add the neutral proteinase of 0.2% (dry), stir, be incubated heat sterilization after 2.5 hours, be cooled to 35 DEG C, inoculation probio heat-preservation fermentation 42 hours;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 25 DEG C of heat-preservation fermentations, when natural termination is fermented, be cooled to room temperature DEG C and continue after insulation ferment 60 days, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, bottling sterilization obtains pure grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain pure grape elite ferment.
Described degreasing Grape Skin ground-slag is grape skin gained after drying, pulverize, squeezing de-oiling of wine brewing gained.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Embodiment 4
A kind of pure grape elite ferment, is characterized in that its raw material consists of according to weight portion: new fresh grape 70 parts, degreasing Grape Skin ground-slag 2.5 parts, grape wine 1 part, HFCS 2.5 parts, white granulated sugar 100 parts, xylo-oligosaccharide 1 part, Arabinose 35 parts, sugar alcohol 5 parts, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase at 48 DEG C of enzymolysis 2-3 hour, then add sterilizing after HFCS, grape wine;
2) step 1) grape skin that obtains adds 5-10 times of water mill slurry, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1.5 hours, then 55 DEG C are heated to, add the neutral proteinase of 0.2% (dry), stir, be incubated heat sterilization after 2.5 hours, be cooled to 35 DEG C, inoculation probio heat-preservation fermentation 42 hours;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 25 DEG C of heat-preservation fermentations, when natural termination is fermented, be cooled to room temperature DEG C and continue after insulation ferment 60 days, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, bottling sterilization obtains pure grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain pure grape elite ferment;
6) 5) or 6) described in step in add polydextrose, l-cn makes the pure grape elite ferment with weight-reducing effect.
Described degreasing Grape Skin ground-slag is grape skin gained after drying, pulverize, squeezing de-oiling of wine brewing gained.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Embodiment 5
A kind of pure grape elite ferment, is characterized in that its raw material consists of according to weight portion: new fresh grape 50 parts, degreasing Grape Skin ground-slag 0 part, grape wine 0 part, HFCS 0 part, white granulated sugar 0 part, xylo-oligosaccharide 0 part, Arabinose 0 part, sugar alcohol 10 parts, probio is appropriate.
A production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase 45 DEG C of enzymolysis 2 hours, then sterilizing;
2) step 1) grape skin that obtains adds 5 times of water mills slurries, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1 hour, then 55 DEG C are heated to, add the neutral proteinase of 0.1% (dry), stir, be incubated heat sterilization after 2 hours, be cooled to 30 DEG C, inoculation probio heat-preservation fermentation 36 hours;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 20 DEG C of heat-preservation fermentations, when zymotic fluid ph value reaches 4.0, are cooled to the warm rear ferment of 15 DEG C of aerations follow-up continuation of insurance in 2 hours 90 days, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, 85 pasteurizes of bottling obtain pure grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain pure grape elite ferment;
6) pure grape elite ferment is made pure grape elite ferment powder through concentrate drying, pulverizing, allotment.
Degreasing Grape Skin ground-slag is grape skin gained after drying, pulverize, squeezing de-oiling of wine brewing gained.
Described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
Embodiment 6 the present invention is on the impact of immunity of organisms
1 experiment purpose
By exercise tolerance test (mouse forced swimming), raising immunity, the antifatigue effect of checking the present invention pure grape elite ferment.
2 experiment materials and reagent
2.1 test sample samples:
Commercially available fruits and vegetables comprehensive enzyme (G1); Pure grape elite ferment (G2-G6) prepared by embodiment of the present invention 1-5.
2.2 reagent:
Liver/muscle glycogen testing cassete, builds up institute of biological products purchased from Nanjing; The concentrated sulfuric acid (AR), Nanjing Chemistry Reagent Co., Ltd.; Physiological saline, Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd..
3. animal used as test
ICR mouse, ♂, cleaning grade, body weight 18-22g, is provided by Ningxia Medical University's comparative medicine center, the free diet of experimental session mouse.
4. key instrument
Aluminum swimming trunk (50cm × 50cm × 40cm), galvanized wire, low-temperature and high-speed centrifuge: 5804R type, Eppendrof company; Water-bath: DK-S26 type, the grand experimental facilities Co., Ltd of upper Nereid; Electronic scale: BS224S type, Sartorius company; Stopwatch, thermometer
5. experiment grouping
5.1 dosage groupings and given the test agent give the time: at random mouse is divided into 6 groups, often organize 10,1st group to the 6th group respectively to the sample specimens of G1 ~ G6,7th group is blank group, give isopyknic distilled water, the often every average daily gavage of group 1 time, gavage volume is 0.2ml/10g, gives given the test agent continuously 30 days.
5.2 sample preparations: the 1st group to the 6th group: take 2.25g sample specimens sample, be assigned to 150ml with distilled water; Blank group (the 7th group): distilled water 150ml.
6. experimental technique
After 6.1 swimming with a load attached to the body experiment last administration 30min, put mouse in swimming trunk, the depth of water is no less than 30cm, water temperature 25 ± 1 DEG C, the sheet lead of mouse root of the tail portion load 5% body weight, and the swimming of record mouse starts to the dead time, as mouse swimming time.
After 6.2 mice serum urea measure last administration 30min, be not swimming with a load attached to the body 90min in the water of 30 DEG C in temperature, eyeball blood sampling 0.5mL (not adding anti-coagulants) is plucked after rest 60min, put 4 DEG C of refrigerator 3h, the centrifugal 15min of 2000r/min after blood clotting, gets serum and send clinical laboratory of Affiliated Hospital of Ningxia Medical University to detect.
After the mensuration last administration 30min of 6.3 hepatic glycogen, be not swimming with a load attached to the body 90min in the water of 25 ± 1 DEG C in temperature, cervical dislocation puts to death mouse, clean with physiological saline, and with after filter paper suck dry moisture, accurately taking liver 100mg, hepatic glycogen detection kit detects Mouse Liver glycogen content.
Take a blood sample after the mensuration last administration 30min of 6.4 blood lactase acid, then do not bear a heavy burden stops after temperature is the water went swimming 10min of 30 DEG C.Lactic acid instrument assay method: after rest 20min, each blood sampling 20 μ L add in 40 μ L rupture of membranes liquid before swimming, after swimming, after swimming respectively, the smudge cells lactic acid instrument that fully vibrates immediately measures.(blood lactase acid TG-AUC=5 × (the blood lactase acid value of the rear 20min of blood lactase acid value+2 × swimming of the rear 0min of front blood lactase acid value+3 × swimming that swims)
7. observation index walking weight load, blood lactase acid, urea, glycogen initial value
8. statistical method experimental data is used
represent, employing t inspection is compared between organizing
9. experimental result
9.1 the present invention pure grape elite ferment is on the impact of mice burden swimming time
After per os gives mouse G1 ~ G6 sample specimens, G1 sample specimens compares with blank group, can obviously extend the mice burden swimming time, there is significant difference (P < 0.05), the present invention's pure grape elite ferment G2 ~ G6 sample specimens compares with blank group, can the significant prolongation mice burden swimming time, there is pole significant difference (P < 0.01), and be obviously better than G1 sample specimens.The results detailed in Table 2.
Table 2 ferment is on the impact of mice burden swimming time
" * " p<0.05vs blank;
" * * " p<0.01vs blank;
9.2 the present invention pure grape elite ferment is on the impact of blood lactase acid before and after mouse movement
After per os gives mouse pure grape elite ferment of the present invention, the present invention's pure grape elite ferment G2 ~ G6 sample specimens to compare with control group blood lactase acid TG-AUC after mouse movement significant difference (P < 0.05), decrease though G1 sample specimens group Mouse Blood lactic acid TG-AUC compares with control group, and no difference of science of statistics (P > 0.05).The results are shown in Table 3.
Table 3 the present invention pure grape elite ferment is on the impact of blood lactase acid level before and after mouse movement
" * " p<0.05vs blank;
9.3 the present invention pure grape elite ferment is on the impact of Mouse Liver glycogen
After per os gives mouse G1 ~ G6 sample specimens, G1 sample specimens compares with blank group, Mouse Liver glycogen content all has obvious rising, there is significant difference (P < 0.05), the present invention's pure grape elite ferment G2 ~ G6 sample specimens compares with blank group, Mouse Liver glycogen content all has obvious rising, has pole significant difference (P < 0.01), and is obviously better than G1 sample specimens.The results detailed in Table 4.
Table 4 the present invention pure grape elite ferment is on the impact of Mouse Liver glycogen content
" * " p<0.05vs blank;
" * * " p<0.01vs blank;
9.4 the present invention pure grape elite ferment is on the impact of mice serum urea
After per os gives mouse G1 sample specimens, G1 sample specimens group compares with blank group, after mouse movement, serum urea content all has obvious reduction, there is significant difference (P < 0.05), the present invention's pure grape elite ferment G2 ~ G6 sample specimens compares with blank group, after mouse movement, serum urea content all has obvious reduction, has pole significant difference (P < 0.01), and is obviously better than G1 sample specimens.The results detailed in Table 5.
Table 5 the present invention pure grape elite ferment is on the impact of mice serum urea content
" * " p<0.05vs blank;
" * * " p<0.01vs blank;
10. experiment conclusion
This experiment is mainly through mice burden swimming experiment, and the deposit simultaneously detecting Mouse Liver glycogen observes the effect that the present invention's pure grape elite ferment improves immunity, antifatigue.Preliminary Results shows below:
1, G2 ~ G6 of the present invention pure grape elite ferment all can extend the mice burden swimming time (P < 0.01), and successful is better than the pure grape elite ferment of other G1.
2, biochemistry detection aspect display, the lactic acid content that after each dosage group of G2 ~ G6 of the present invention pure grape elite ferment all can reduce motion, in mice serum, glucose anerobic glycolysis produces, compare with control group and have significant difference (P < 0.05), and although the ferment of other G1 also can reduce the lactic acid content that in the rear mice serum of motion, glucose anerobic glycolysis produces, but compare with control group, no difference of science of statistics (P > 0.05);
3, each dosage group of G3 ~ G7 of the present invention pure grape elite ferment all can significantly improve the deposit (P < 0.01) of glycogen in mouse liver, and successful is better than the pure grape elite ferment of other G1;
4, high lithemia model finds, G2 ~ G6 of the present invention pure grape elite ferment significantly can reduce the content (P < 0.01) of the rear urea in serum of mouse swimming, and successful is better than the commercially available comprehensive pectase of other G1;
11. conclusions
Above-mentioned experiment proves that the present invention's pure grape elite ferment can significantly improve immunity of organisms, improve muscle power and the endurance of mouse, the content of urea in serum and lactic acid after reduction mouse movement, and the deposit of glycogen in mouse liver can be significantly improved, contribute to the fatigue that alleviation exercise load causes; The time that mice burden swimming to power exhausts can be extended.
The anti-oxidant experiment of embodiment 7 pure grape elite ferment
1 materials and methods
1.1 samples with pure grape elite ferment for primary raw material.Every day 2 times, each 30 milliliters, get 30 milliliters of pure grape elite ferment, dilute 5 times, make oral liquid.
45 ~ 65 years old age is selected in 1.2 experimental designs, and good 120 volunteers of health are as study subject.By MDA (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) level, test-meal group and control group are divided at random to experimenter, consider that the principal element affecting result is as age, sex and eating habit etc. as far as possible, carry out harmony inspection, comparativity between guarantee group.
1.3 key instruments and reagent Japan produce Hitachi 7600 automatic clinical chemistry analyzer.
1.4 observation index Liver and kidney function check, MDA, SOD, GSH-Px in serum.
1.5 Application of Statistic Methods statistic software SPSSs 11.5, experimental data x ± s represents, compares t inspection and carry out statistical analysis before and after employing experiment between paired t-test and group.
2 results
Before and after 2.1 Biochemical Indexes experiments, the every biochemical indicator creatinine (CRE) of experimenter, urea nitrogen (BUN), glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), total protein (TP), albumin (ALB), Archon ratio (A/G) etc. are all in range of normal value, without significantly changing, in table 1.
2.2MDA, SOD, GSH-Px index and paired t-test the results are shown in Table 2.
2.3MDA, SOD, GSH-Px index and independent samples t-test the results are shown in Table 3.
Table 1 pure grape elite ferment antioxidation human experiment experiment biochemical indicator testing result (x ± s)
The experiment of table 2 pure grape elite ferment element antioxidation human experiment MDA, SOD, GSH-Px paired t-test result
The experiment of table 3 pure grape elite ferment antioxidation human experiment MDA, SOD, GSH-Px independent samples t-test result
3 discuss
The old and feeble theory of Herman free radical is thought, the effect of free radical random disruptions causes lipid peroxidation and causes biomembrane damage, makes life macromolecule cross-linked polymeric, lipofuscin accumulation, destroys or reduces organ-tissue cell, reducing immunologic function, cause body aging.
Pure grape elite ferment contains multiple phenolic hydroxyl group, discharges H+, be combined competitively with free radical and oxide after oxidized in vivo, thus protection lipid is not oxidized, blocks free chain reaction.Oxygen radical in pure grape elite ferment purged body carries out with enhancing body antioxidase activity process simultaneously.MDA is the final catabolite of lipid peroxidation, and pure grape elite ferment, by the oxygen radical in purged body, makes MDA content in serum significantly reduce; Simultaneously by effectively removing various active oxygen radical, singlet-oxygen quenching, enhancement of SOD is active; By suppressing excessive H
2o
2generation, make glutathione return to normal level, recover and enhance the activity of GSH-Px, thus the antioxidant system of strengthening body.In this experimental result test-meal group serum, MDA on average declines 4.80%; SOD on average raises 2.31%; GSH-Px on average raises 2.45%, and have statistical significance (P<0.01) by paired t-test and independent samples t-test comparing difference, this is consistent with Results of Animal.Pure grape elite ferment can effectively improve activities of antioxidant enzymes in body, scavenging free radicals, reduces body lipid peroxidating occurred level, to promotion human body, health is significant.
It should be noted that: pure grape elite ferment powder prepared by the embodiment of the present invention 5 has above-mentioned experiment effect equally.
Claims (4)
1. a pure grape elite ferment, it is characterized in that its raw material consists of according to weight portion: new fresh grape 50-90 part, degreasing Grape Skin ground-slag 0-5 part, grape wine 0-2 part, HFCS 0-5 part, white granulated sugar 0-100 part, xylo-oligosaccharide 0-2 part, Arabinose 0-35 part, sugar alcohol 0-10 part, probio is appropriate.
2. a production method for pure grape elite ferment, it comprises following steps:
1) new fresh grape cleaning, destemming, broken, squeeze the juice, obtain grape juice and grape skin, in grape juice, add pectase and cellulase at 45-50 DEG C of enzymolysis 2-3 hour, then add sterilizing after HFCS, grape wine;
2) step 1) grape skin that obtains adds 5-10 times of water mill slurry, degreasing Grape Skin ground-slag is added in slurries, be heated to 45 DEG C, add pectase and cellulase, enzymolysis 1-2 hour, then 55 DEG C are heated to, add the neutral proteinase of 0.1-0.3% (dry), stir, be incubated heat sterilization after 2-3 hour, be cooled to 30-40 DEG C, inoculation probio heat-preservation fermentation 36-48 hour;
3) by step 2) zymotic fluid that obtains adds step 1) in the sterilizing slurries that obtain, 20-30 DEG C of heat-preservation fermentation, when zymotic fluid ph value reaches 3.0-4.0 or natural termination fermentation, be cooled to 15-20 DEG C and continue the rear ferment 30-90 days of insulation, centrifugation is removed slag, and obtains pure grape elite ferment stoste.
4) add xylo-oligosaccharide, Arabinose, sugar alcohol, white granulated sugar in pure grape elite ferment stoste, bottling sterilization obtains grape elite ferment;
5) add xylo-oligosaccharide, Arabinose, sugar alcohol in pure grape elite ferment stoste, adjust soluble solid content to reach more than 60% with white granulated sugar and bottle and obtain grape elite ferment.
3. pure grape elite ferment according to claim 1 and 2 and production method, it is characterized in that described degreasing Grape Skin ground-slag be wine brewing gained grape skin gained after drying, pulverize, squeezing de-oiling.
4. pure grape elite ferment according to claim 1 and 2 and production method, it is characterized in that described probio is bifidobacterium adolescentis, animal bifidobacteria (bifidobacterium lactis), bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, bacillus coagulans, Lactobacillus casei, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus (lactobacillus bulgaricus), bacillus cereus, Lactobacillus delbrueckii breast subspecies, lactobacillus fermenti, lactobacillus gasseri, Lactobacillus helveticus, Yue Shi lactobacillus, lactobacillus paraceasi, lactobacillus reuteri, Lactobacillus rhamnosus, bacillus subtilis, Lactobacillus salivarius, streptococcus thermophilus, Lactobacillus plantarum, bacillus licheniformis, lactobacillus paraceasi, Lactobacillus rhamnosus, lactobacillus acidophilus, leuconostoc mesenteroides subsp mesenteroides, kluyveromyces marxianus, Pediococcus acidilactici, one or more in Pediococcus pentosaceus.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105919101A (en) * | 2016-05-19 | 2016-09-07 | 湖南曙光山城酒业有限公司 | Brier grape enzyme beverage and brewing process thereof |
| CN106173674A (en) * | 2016-07-18 | 2016-12-07 | 广西顺帆投资有限公司 | A kind of Succus Momordicae charantiae and preparation method thereof |
| CN106222108A (en) * | 2016-08-10 | 2016-12-14 | 青岛科拓恒通乳酸菌产业化开发研究院有限公司 | For promoting compound lactobacillus microbial inoculum and the preparation method of grape quality |
| CN106387897A (en) * | 2016-04-11 | 2017-02-15 | 刘祖波 | Preparation method of Luohanshen ferment stock solution |
| CN106993807A (en) * | 2017-05-02 | 2017-08-01 | 辽宁晟启昊天生物医药科技有限公司 | A kind of preparation method of ginger ferment |
| CN107125744A (en) * | 2017-06-25 | 2017-09-05 | 上海草圣生物科技有限公司 | Polypeptide pectase |
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| CN109953321A (en) * | 2017-12-25 | 2019-07-02 | 海南合生源生物科技有限公司 | The preparation method of grape ferment |
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| CN110839794A (en) * | 2019-10-14 | 2020-02-28 | 甘肃赛贝露生物科技有限责任公司 | Samantha rose grape enzyme beverage capable of maintaining beauty and keeping young and production method thereof |
| WO2020073437A1 (en) * | 2018-10-10 | 2020-04-16 | 长春健康未来医药科技有限公司 | Extract for preventing oxidation, delaying aging, and nourishing heart and cerebral vessels, and preparation method therefor |
| CN111281833A (en) * | 2020-04-14 | 2020-06-16 | 海南易筠化妆品有限公司 | Preparation method of grape skin seed residue rice fermentation liquor, and formula and application of facial mask thereof |
| CN111494269A (en) * | 2020-06-05 | 2020-08-07 | 上海全丽生物科技有限公司 | Grape fermentation raw pulp and preparation method and application thereof |
| CN114431440A (en) * | 2022-02-25 | 2022-05-06 | 广州市沐家健康产业有限公司 | Peach pomegranate collagen enzyme jelly and preparation method and application thereof |
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| CN108713747A (en) * | 2018-05-31 | 2018-10-30 | 厦门元之道生物科技有限公司 | It is a kind of to have effects that mend the comprehensive enzyme liquid and preparation method thereof of iron |
| WO2020073437A1 (en) * | 2018-10-10 | 2020-04-16 | 长春健康未来医药科技有限公司 | Extract for preventing oxidation, delaying aging, and nourishing heart and cerebral vessels, and preparation method therefor |
| CN110250454A (en) * | 2019-06-03 | 2019-09-20 | 中国海洋大学 | A method of producing Grape Skin ferment |
| CN110839794A (en) * | 2019-10-14 | 2020-02-28 | 甘肃赛贝露生物科技有限责任公司 | Samantha rose grape enzyme beverage capable of maintaining beauty and keeping young and production method thereof |
| CN111281833A (en) * | 2020-04-14 | 2020-06-16 | 海南易筠化妆品有限公司 | Preparation method of grape skin seed residue rice fermentation liquor, and formula and application of facial mask thereof |
| CN111494269A (en) * | 2020-06-05 | 2020-08-07 | 上海全丽生物科技有限公司 | Grape fermentation raw pulp and preparation method and application thereof |
| CN111494269B (en) * | 2020-06-05 | 2023-04-07 | 上海全丽生物科技有限公司 | Grape fermentation raw pulp and preparation method and application thereof |
| CN114431440A (en) * | 2022-02-25 | 2022-05-06 | 广州市沐家健康产业有限公司 | Peach pomegranate collagen enzyme jelly and preparation method and application thereof |
| CN114431440B (en) * | 2022-02-25 | 2023-07-21 | 广州市巴菲巴健康产业有限公司 | Nectarine and pomegranate collagen ferment jelly and preparation method and application thereof |
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