CN105250913B - A kind of pharmaceutical composition for treating laying hen fatty liver syndrome - Google Patents
A kind of pharmaceutical composition for treating laying hen fatty liver syndrome Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical compositions for treating laying hen fatty liver syndrome, its composition by weight are as follows: 30-50 parts of Rabdosia lophanthoides, 30-50 parts of creeping oxalis, 30-50 parts of polygonum cuspidate, 25-45 parts of stringy stonecrop, 25-45 parts of calyx meto, 20-40 parts of Caulis Spatholobi, 15-35 parts of Rhizoma Chuanxiong, 15-35 parts of Radix Curcumae, 15-35 parts of potentilla discolor, 15-35 parts of field thistle, 10-30 parts of rheum officinale, 10-30 parts of cassia seed, 10-30 parts of Rhizoma Atractylodis Macrocephalae, 10-30 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol, clinical application indicate that having special efficacy to treatment laying hen fatty liver syndrome.Through clinical treatment statistical confirmation, cure rate is up to 95.23%, efficient 100%.And so that its product meat is reached nuisanceless requirement, the health of people has been effectively ensured.
Description
Technical field
The present invention relates to technical field of Chinese veterinary medicine more particularly to a kind of for treating the medicine group of laying hen fatty liver syndrome
Close object and preparation method thereof.
Background technique
Laying hen fatty liver syndrome (fatty liver hemorrhagic syndrome, FLH), is dystrophia, rouge
The reasons such as fat metabolism disorder, endocrine disorder cause a kind of specific type liver diseases that fat deposition increases in liver cell, again
Referred to as fatty liver hemorrhagic syndrome (FLHS) is the most common disorders of lipid metabolism disease of batterylaying.Fat occurs with liver
Being denaturalized is main pathological change, with individual fat, unexpected, a height of Clinical symptoms of case fatality rate of falling ill.Have become many states in the world
The common disease of family, in China and many poultry one of enterprises and the most common disease of peasant household.The disease is mainly since chicken is laid eggs
Peak period organism metabolism is vigorous, search for food high energy low-protein diet and make fat metabolic disturbance, cause very low density lipoprotein to be closed
At and transhipment be obstructed, fat excessively accumulated in liver cell.And since the Fatty synthesis place of chicken is mainly liver, to influence
Liver normal function can cause liver cell to rupture when serious, eventually lead to diseased chicken liver internal haemorrhage and dead.Disease incidence is in 5%-
10%, individual serious chicken farm disease incidence are up to 30%, and egg production decline 5%~50%, occurred all year round for the disease,
It is in the majority with summer, it is very harmful, huge economic loss is caused to poultry husbandry.
There are many reason of causing laying hen fatty liver syndrome, including heredity, nutrition, management, environment, hormone and toxicity
Substance etc..Studies have shown that the same rearing conditions, but the chicken of different lines is different to the neurological susceptibility of FLS, illustrates inherent cause pair
The disease has an impact.May be in hereditary and selection using laying rate as index be cause laying hen occur fatty liver the reason of one of,
High laying intensity is a kind of stronger stress factor, it is easy to by certain subclinical diseases excitation and cause the disease, Er Qiegao
The intracorporal estrogen metabolism enhancing of laying hen, the content of liver fat also increase when production.It is energy mistake first in terms of trophic factor
Surplus, Energy intaking is excessively that the main reason for this disease is formed, especially batterylaying are easy morbidity.Carbon hydrate is taken in too much
When object, superfluous portions turn is fat, and liver rouge is caused to become and liver cell is caused to become fragile with vascular wall and liver occurs and goes out
Blood.Secondly, Dietary Energy albumen is than inducement that is excessively high and causing laying hen to fall ill.Fat into liver also needs and protein
Liver can just be transported by being combined into lipoprotein, but Low protein diet is difficult to provide enough protein and be combined with fat, so as to cause
Fat largely deposits in liver.Same high protein low energy feed can also cause the accumulation of fat, because of protein-caloric ratio in feed
Value is big, and corresponding energy is just less than normal, and a part of protein and amino acid slough amide and generates glucose as the energy, thus de-
A large amount of nitrogen urea synthesis in liver, increase the metabolic burden of liver after ammonia, so that inducing or causing to fall ill.Furthermore laying hen
Feed difference also will affect content fatty in liver.Low calcium feed will increase liver extent of hemorrhage, increase weight and liver again,
Egg drop reduction.Selenium deficiency will appear liver bleeding in feed, because selenium can protect blood vessel endothelium.If lipid transfer is also to cause to send out
One of the reason of disease, the shortages such as anti-fattyliver substance such as choline, methionine can also promote the development of hepatic steatosis.Stress
Aspect, it is any type of stress, such as nutrition, management, disease, can become the inducement of this disease.The energy of chicken needs under hot environment
Reduction is asked, lipolysis can be caused to reduce, the synthesis of liver fat acid increases, and promotes lipopexia.Furthermore batterylaying is
One important risk factor reduces the energy for moveing freely consumption, so superfluous energy because it limits the activity of chicken
Amount is easily converted into fat.So the liver fat of batterylaying raising layer more flat than ground is more.There are also some hormones, such as estrogen
Deng, can by improve energetic supersession source, promote carbohydrate to be transformed into fat, induce the generation of fatty liver.It is yellow in feed
How much aspergillus content is also one of the main reason for causing fatty liver syndrome.
Suffer from chicken mostly in order, does not show any symptom, only body is more fertile, and abdomen expands sagging.Minority suffer from chicken cockscomb,
Pale anaemia at wattle, comb end have livid purple, and happiness is sleeping, sleeping to be contacted to earth with breastbone often or lain on the left side ground.A left side is intraperitoneal obviously to be had
Red liquid can be extracted out with syringe needle.
Dissect chicken corpse is fat, and appearance is not damaged, between subcutaneous abdomen, flesh, two femoribus internus accumulate volume fat.It opens
Find that volume fat is also all built up at the positions such as abdominal cavity, internal organs and mesenterium behind abdominal cavity.There are side or two in most of dead chicken abdominal cavities
Side property abdomen watery blood and blood clot, liver disruption.Liver enlargement, periphery blunt circle, discoloration is yellow, and quality is soft easily broken.Some goes out
The now alternate striped of apparent reddish yellow, liver envelope are easily removed, and some envelopes dissolve.Gollbladder dilation or diminution, cyst wall is because of fat
It deposits and thickens.Spleen matter is soft, generally loses enlargement.Muscular stomach is since the fat being deposited wraps up, and volume reduces, muscular stomach content
Object is few, and endothelium corneum gigeriae galli is thin and easily peelable, and muscle layer is thinning.The ovarian follicle that has in ovary and fallopian tubal stops development, intraperitoneal to have deformation
Yolk, some are detained the egg for only having shell membrane in isthmus.Kidney slightly enlargement, matter are crisp.Heart pericardium expansion, hydropericardium, heart
Coronary sulcus, longitudinal furrow fat deposition are obvious, and apex has pea-sized fat globule to build up.
The sterile liver for taking the chicken that dies of illness is sliced.The visible degeneration of liver cells under mirror, less serious case is rarely seen list in endochylema
A or multiple fat drips distributions, liver rope are still distinguished with sinus hepaticus structure；Slightly the visible multiple fat drips of severe one are fused into a big fat drips, and will
Karyon is pressed onto side, and existing big vacuole in endochylema, liver rope is distinguished unobvious with sinus hepaticus；The necrosis of liver cells in the area severe one Ze Zhibian disappears
It loses, and is substituted by reticuloendothelial cell hyperplasia, so the reticuloendothelial cell hyperplasia for having volume focal divides in section preparation
Cloth, interstitial are also filled with adipose tissue.The organa parenchymatosums such as liver, spleen, lymph node are taken with sterile working, tissue contact are made into, through removing from office
Microscopy after blue Albert'stain Albert has not observed any pathogenic bacteria or polypide.Sterile working takes the organs such as liver, spleen, lymph node, sterile to connect
Kind is observed after 37 DEG C of 24 h of constant temperature incubation on plain agar, maconkey agar and blood nutrient agar, as a result
It is negative.Then extract and suffer from heart blood, the estrogen in measurement cholesterol in serum, calcium and phosphorus, blood plasma, content significantly
It is exceeded.Cholesterol reaches 13.82-24.62mmol/L (normal value: 2.90-8.17mmol/L), serum calcium 6.14-14.38mmol/L
(normal value: 3.74-6.49mmol/L).
Treatment for this disease, clinically mostly is to add some Western medicine merely in feed, it is possible to reduce adult laying hen
Fat content in liver, palliative although can temporarily delay the state of an illness, curative effect is simultaneously unsatisfactory.Large quantities of funds are put into,
Reduce the benefit of raising laying hen.And in terms of using the method treatment laying hen fatty liver syndrome of Integrated TCM, have original
Advantage, it is cheap, toxic side effect is small, source is wide.Not only save the cost, but also the state of an illness can be controlled in a relatively short period of time,
It is dead to reduce laying hen, and then improves culture efficiency.Therefore, it is badly in need of a kind of Chinese and Western medicine combination for laying hen fatty liver syndrome
Object, for clinical application.
Summary of the invention:
The technical problem to be solved by the present invention is to overcome in the shortcoming for the treatment of laying hen fatty liver syndrome, provide at present
A kind of materials are easy, preparation is convenient, reduces medicament residue and toxic side effect, and cheap treated, imitated preferable therapeutic agent group
Close object.We have many advantages, such as whole good effect, are not likely to produce that drug resistance, residual is low, toxic side effect is small, for promotion poultry husbandry
Sound development have highly important economy and society meaning.
The present invention provides the following technical solutions: a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, it
Composition by weight are as follows: 30-50 parts of Rabdosia lophanthoides, 30-50 parts of creeping oxalis, 30-50 parts of polygonum cuspidate, 25-45 parts of stringy stonecrop, calyx meto
25-45 parts, 20-40 parts of Caulis Spatholobi, 15-35 parts of Rhizoma Chuanxiong, 15-35 parts of Radix Curcumae, 15-35 parts of potentilla discolor, 15-35 parts of field thistle, rheum officinale
10-30 parts, 10-30 parts of cassia seed, 10-30 parts of Rhizoma Atractylodis Macrocephalae, 10-30 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, inositol 10
Part.
Preferred composition by weight are as follows: 40-50 parts of Rabdosia lophanthoides, 30-40 parts of creeping oxalis, 40-50 parts of polygonum cuspidate, stringy stonecrop
25-35 parts, it is 35-45 parts of calyx meto, 20-30 parts of Caulis Spatholobi, 25-35 parts of Rhizoma Chuanxiong, 15-25 parts of Radix Curcumae, 25-35 parts of potentilla discolor, small
15-25 parts of Ji, 20-30 parts of rheum officinale, 10-20 parts of cassia seed, 20-30 parts of Rhizoma Atractylodis Macrocephalae, 10-20 parts of rhizoma alismatis；
Preferred composition by weight are as follows: 30-40 parts of Rabdosia lophanthoides, 40-50 parts of creeping oxalis, 30-40 parts of polygonum cuspidate, stringy stonecrop
35-45 parts, it is 25-35 parts of calyx meto, 30-40 parts of Caulis Spatholobi, 15-25 parts of Rhizoma Chuanxiong, 25-35 parts of Radix Curcumae, 15-25 parts of potentilla discolor, small
25-35 parts of Ji, 10-20 parts of rheum officinale, 20-30 parts of cassia seed, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 20-30 parts of rhizoma alismatis；
Or are as follows: 50 parts of Rabdosia lophanthoides, 50 parts of creeping oxalis, 50 parts of polygonum cuspidate, 45 parts of stringy stonecrop, 45 parts of calyx meto, Caulis Spatholobi
40 parts, 35 parts of Rhizoma Chuanxiong, 35 parts of Radix Curcumae, 35 parts of potentilla discolor, 35 parts of field thistle, 30 parts of rheum officinale, 30 parts of cassia seed, 30 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis
30 parts；
Or are as follows: 30 parts of Rabdosia lophanthoides, 30 parts of creeping oxalis, 30 parts of polygonum cuspidate, 25 parts of stringy stonecrop, 25 parts of calyx meto, Caulis Spatholobi
20 parts, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Curcumae, 15 parts of potentilla discolor, 15 parts of field thistle, 10 parts of rheum officinale, 10 parts of cassia seed, 10 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis
10 parts；
Or are as follows: 40 parts of Rabdosia lophanthoides, 40 parts of creeping oxalis, 40 parts of polygonum cuspidate, 35 parts of stringy stonecrop, 35 parts of calyx meto, Caulis Spatholobi
30 parts, 25 parts of Rhizoma Chuanxiong, 25 parts of Radix Curcumae, 25 parts of potentilla discolor, 25 parts of field thistle, 20 parts of rheum officinale, 20 parts of cassia seed, 20 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis
20 parts.
A further object of the present invention is to provide a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, is by following
Method preparation:
1) each component is weighed by a kind of raw material proportioning of pharmaceutical composition for treating laying hen fatty liver syndrome, by strain line perfume
After tea dish, polygonum cuspidate, calyx meto, Caulis Spatholobi, rheum officinale, cassia seed crush, the alcohol of 60-70% is added repeatedly to extract, merges leachate,
Filtering removal ethyl alcohol, concentration obtain medical fluid 1；
2) by creeping oxalis, stringy stonecrop, Rhizoma Chuanxiong, Radix Curcumae, potentilla discolor, field thistle, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis grinding and sieving, decoction is filtered out
The dregs of a decoction are removed, filtrate is taken, is concentrated, obtains medical fluid 2.
3) medical fluid 1 is merged with medical fluid 2, methionine, choline chloride, inositol is added, mixed；
A kind of pharmaceutical composition for treating laying hen fatty liver syndrome, 1.29-1.32g/ml containing crude drug.
Composition principle of the invention:
Motherland's tradition veterinary science thinks: the relationship of liver and spleen is very close, and physiologically, liver controlling conveyance and dispersion, The spleen has the function to transport and transform nutrients, liver
Store blood, The spleen governs the blood.Spleen obtains the catharsis of liver, then coordination between ascending and descending, and transportation capabilities are healthy and vigorous.Pathologically liver and spleen also influences each other, if liver is lost
Catharsis can cause " the liver failing to dredge the spleen "；If spleen deficiency loses fortune, no resource of generating and transforming QI and blood, then liver is without being grown.Due to laying hen Long-term Feeding high energy
Feed is measured, cage bird amount of exercise is insufficient in addition, and work and rest is not normal, and coup injury taste cause essence of water and grain that cannot spread to by spleen
Whole body and turn to phlegm wet.Liver has ascension the whole body yang-energy, the effect of harmonizing the functional activities of vital QI.Since irritability has a characteristic of main liter hair, therefore its
The interpretation of the cause, onset and process of an illness is let out too with rising to be common, and the pathological changes such as liver-yang hyperactivity or upward invasion of liver-QI are shown as more.Therefore have that " irritability liver-yang often has again
It is remaining " say.Irritability is had a surplus, liver with for, liver body involvement, so on the one hand due to the stagnation of the circulation of vital energy and blood is obstructed, one side liver blood is dark
Consumption and it is insufficient.So laying hen fatty liver hemorrhagic syndrome is formed as that liver dysfunction, that spleen fortune loses strong, retention of damp-heat in the interior, phlegm is turbid
Pent-up, stagnation of blood stasis and eventually lead to damp phlegm stasis blocking liver train of thought, body cannot by foodstuff essence it is micro- normally distribution be transported to
Whole body everywhere, so that fat, the accumulation of liquid phlegm wet occur among skin, internal organs, cause a series of clinical symptoms of fatty liver with
Sign.
, in the treatment should be based on Shugan Qingre, the esterified stasis of blood of dispelling for the interpretation of the cause, onset and process of an illness of this disease, and dispelled with replenishing qi to invigorate the spleen, stopping blooding
Phlegm.We are by Rabdosia lophanthoides, creeping oxalis, polygonum cuspidate, stringy stonecrop, calyx meto, Caulis Spatholobi, Rhizoma Chuanxiong, Radix Curcumae, potentilla discolor, field thistle, big
Huang, cassia seed, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis, methionine, choline chloride, ten seven flavor medicine of inositol composition, prescription is rigorous, and actual situation is taken into account.Square middle line
Line Rabdosia amethystoides, nature and flavor sweetness and bitterness is cool, enters Liver Channel.Have effects that clearing heat and promoting diuresis, cool blood dissipates the stasis of blood, removing jaundice clearing damp, is the acute Huang for the treatment of
The conventional Chinese medicine of the illnesss such as subcutaneous ulcer type hepatitis, cholecystitis；Creeping oxalis, nature and flavor acid are cold, return large intestine, stomach, Liver Channel, have clearing heat and promoting diuresis,
Cool blood dissipates the stasis of blood, the efficacy of removing toxicity for detumescence, with diarrhea, dysentery is controlled, the illnesss such as jaundice are clinically often used with Rabdosia lophanthoides compatibility
Hepatopathy is controlled, especially acute icteric hepatitis has a better effect；Polygonum cuspidate mildly bitter flavor, cold nature.Return liver, gallbladder, lung channel.Effect is clear
Thermal detoxification, removing dampness through diuresis and removing jaundice, removing blood stasis and acesodyne, it is relieving cough and reducing sputum.Three medicines share, and it is in side that clearing heat and promoting diuresis, the function of cool blood dissipates the stasis of blood are especially aobvious
Monarch drug in a prescription.Stringy stonecrop is sweet in flavor, light, cool in nature, enters liver, lung channel, has clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence, with controlling jaundice with damp-heat pathogen, pulmonary abscess
Deng card；Calyx meto nature and flavor: it is bitter, it trembles with fear.Returns spleen, stomach, Liver Channel have good hepatoprotective effect.Two medicines match, the work of protecting liver, lowering enzymes
With stronger.It is Caulis Spatholobi bitter but slightly sweet taste, warm-natured, return liver, the heart, kidney channel, activate blood and relax tendons, the benefits of nourishing blood for regulating menstruation, cures mainly rheumatic arthralgia
Deng card；Rhizoma Chuanxiong pungent-warm enters liver, gallbladder, pericardium channel, energy blood-activating and qi-promoting, wind-expelling pain-stopping, with the card for controlling stagnation of QI-blood；Radix Curcumae is pungent, bitter,
It is cold, enter liver, the heart, lung channel, there is promoting qi circulation and removing obstruction in the collateral, stasis-dispelling and pain-killing, the function of normalizing gallbladder to cure jaundice blinds clear key, qi stagnation hemagglutination, blood for turbid pathogenic factor
The absurd row of heat and have that the stasis of blood is stagnant concurrently and the diseases such as jaundice.Three medicines are harmonious, the function with promoting blood circulation and removing obstruction in channels, soothing the liver lipid-loweringing.Above-mentioned five medicine is common
Ministerial drug in composition side.Potentilla discolor is sweet, slight bitter, flat, has clearing heat and detoxicating, cooling blood and hemostasis, can treat dysentery, diarrhea and it is various go out
Mass formed by blood stasis etc.；Field thistle sweet, bitter, cold, converge to heart and liver channels.With cooling blood and hemostasis, the function of eliminating stasis to resolve swelling is used for various haemorrhages.Two medicine phases
It closes, the function of cooling blood and hemostasis dissolving stasis lipid-loweringing is especially aobvious.Gynostemma pentaphylla bitter, micro-sweet, cool in nature, return lung, spleen, kidney channel, effect replenish qi to invigorate the spleen,
Preventing phlegm from forming and stopping coughing, it is clearing heat and detoxicating, cure mainly asthenia, the card such as nephrasthenia emission；Rhizoma Atractylodis Macrocephalae is sweet, bitter, and temperature enters spleen, stomach meridian, has tonifying spleen benefit
Gas, eliminate dampness and have diuretic effect, the function of strengthening exterior and reducing sweat, for the important drugs invigorated the spleen and benefited qi, and can invigorating the spleen to dry, match with gynostemma pentaphylla, be good for
Spleen eliminating dampness, the function of QI invigorating resolving sputum are stronger；Rheum officinale is bitter, trembles with fear.Enter spleen, stomach, large intestine, liver, pericardium channel, stasis removing, purging fire and cooling blood is lived
Blood and dissolving stasis cures mainly constipation and stagnates, and for the key medicine that bitter cold is captured, under can rushing down and expels the heat-evil, there are also the effects of promoting blood circulation；Certainly
Pine torch is sweet, bitter, slightly cold, returns liver, gallbladder, kidney three to pass through, has the effect of heat-clearing, improving eyesight, ease constipation；Rhizoma alismatis is sweet, light, trembles with fear, enters kidney, bladder
Through effect clearing damp and promoting diuresis rushes down kidney fire, is mainly used to rush down kidney fire and bladder heat.Three medicines share, and clearing heat and eliminating phlegm, invigorating the spleen are rushed down turbid.More than
Seven flavor medicine is adjuvant altogether.Full presciption medicine object close and use it, be total to long memorial liver and clearing heat, the esterified stasis of blood of dispelling, replenish qi to invigorate the spleen, stop blooding eliminating the phlegm it
Function has a good effect laying hen fatty liver syndrome.
Modern veterinary pharmacology research has shown that:
Rabdosia lophanthoides: being the conventional Chinese medicine for treating hepatopathy, for treating acute icteric hepatitis, acute cholecystitis, rouge
The illnesss such as fat liver syndrome, main active are Flavonoid substances, significantly inhibit duplication effect to hepatitis virus, there is liver protection
The effect of lipid-loweringing.
Creeping oxalis: and the common drug for the treatment of catarrhal jaundice, have protection to hepatic injury containing a variety of effective ingredients and makees
With liver function can be restored.
Polygonum cuspidate: containing anthraquinone analog compound and flavonoids Multiple components, can extract from its rhizome with component for reducing blood fat
Polydatin etc..In relation to it is demonstrated experimentally that polygonum cuspidate plays the role of reducing cholesterol and triglycerides.
Stringy stonecrop: Sarmentosin has the serum glutamic pyruvic transminase effect that is substantially reduced, and effect is rapid and lasting, clinically may be used
Be applied alone can treat catarrhal jaundice (including acute icterohepatitis, acute no icterepatitis and metastatic hepatitis, slowly
The active stage of property hepatitis).
Calyx meto: having good hepatoprotective effect, and the liver cell of damage can be promoted to repair, and liver function recovery is normal, commonly uses
Acute icteric catarrhal jaundice is treated, has apparent effect of reducing enzyme levels to serum alanine aminotransferase (ALT) raising.
Caulis Spatholobi: being adjustable intracorporal lipid-metabolism, has decreasing trend to the plasma cholesterol of hyperlipidemia chicken, and have drop
Pressure and antitumaous effect.
Rhizoma Chuanxiong: the effect of Central nervous system has sedation, has inhibiting effect to a variety of germs.
Radix Curcumae: having apparent hepatoprotective and cholagogic effects, hepatocellular injury can be made obviously to be repaired, and has drop to toxic hepatitis
Low SGPT, the effect of Total plasma protein is improved, and impaired liver cell mitochondria and rough surfaced endoplasmic reticulum (RER) can be made to restore normal；It is right
Free radical caused by CCl1 has deactivation, and can inhibit the lipid peroxidation of hepatomicrosome, plays a protective role to liver；Energy
Promote the generation and secretion of bile, and gall-bladder can be shunk, promotes bile discharge；And has and promote hepatic glycogen synthesis and hepatic glycogen point
The effect of solution.
Potentilla discolor: contain a variety of active ingredients such as fumaric acid, gallic acid, Quercetin, protocatechuic acid, naringenin, tool
Have antibacterial, antidiarrheal, it is hypoglycemic and antitumor the effects of.
Field thistle: energy vasoconstriction shortens the clotting time, has apparent anastalsis, and can antibacterial；In addition, there are also cholagogue,
Reduce the effect of blood cholesterol.
Gynostemma pentaphylla: main effective ingredient is gynosaponin, gynostemma pentaphylla glucoside etc., can treat hyperlipidemia, viral liver
The card such as inflammation, has effects that protecting liver and detoxication, lowering blood pressure and blood fat blood glucose.
Rhizoma Atractylodis Macrocephalae: there are diuresis and hypoglycemic effect.
Rheum officinale: have the effects that reduce blood pressure, reduce cholesterol, triglycerides, hyperlipidemia can be treated.
Cassia seed: substance containing anthraglycosides generates rheum emodin, Physcion etc. after decomposition, have lowering blood pressure and blood fat,
The effects of antibacterial, can be used for treating hyperlipidemia.
Rhizoma alismatis: main component is volatile oil, includes furfural, and ethanol extract contains alkaloid, phytosterol and lucid asparagus
Element, water and benzene extractives have anti-fatty liver ingredient, have anti-fatty liver, diuresis, while can reduce blood middle cholesterol content
With reduce blood pressure, blood glucose etc..
Methionine: there is preferable treatment to fatty liver, cirrhosis and various acute, chronic, viral, icterepatitis
Effect.It can promote liver plasma membrane phospholipid methylation, membrane fluidity is made to enhance Na+、K+ATP enzyme pumping action is strong, it is possible to reduce liver
The siltation of intracellular bile turns sulfenyl effect and reinforces, to enhance cysteine in liver cell, glutathione and taurine
Synthesis, reduces bile acid and builds up in liver, strengthen detoxication, is conducive to liver cell and restores normal physiological function, promotes
Jaundice subsides and liver function recovery.
Choline chloride: for treating fatty liver and cirrhosis, it also can be used as poultry and livestock feed additive, ovary can be stimulated voluminous
The weight gain such as egg, farrowing and poultry, fish.Choline can promote liver, the fat metabolism of kidney；Or the base of body synthesis acetylcholine
Plinth, to influence the transmitting of nerve signal；In addition choline is also one of methyl source needed for internal methionine synthesis, lacks choline
It can lead to fatty liver, phenomena such as slow growth, laying rate reduces, and death increases.
Inositol: helping to remove the fat of liver, plays the role of fat metabolism and cholesterol, reduces cholesterol, helps prevention
The effects of artery sclerosis helps the reallocation of body fat, reduces cholesterol.
All medicines share altogether at Shugan Qingre, the esterified stasis of blood of dispelling, replenish qi to invigorate the spleen, the agent for eliminating the phlegm of stopping blooding, it is comprehensive to laying hen fatty liver
Disease has a good effect.
System side's feature: we have Shugan Qingre, the esterified stasis of blood of dispelling, replenish qi to invigorate the spleen, the function for eliminating the phlegm of stopping blooding, to laying hen fatty liver
Syndrome has a good effect.Above-mentioned Chinese and western drugs dialectical compatibility and are mutually assisted through organic assembling, and it is soothing the liver to enhance the party
Dispel rouge the effect of, thus achieve the purpose that cure laying hen fatty liver syndrome.Using the soup of Integrated TCM produced by the present invention
Agent effect is more obvious, clinical application indicate that, there is special efficacy to treatment laying hen fatty liver syndrome.It counts and demonstrate,proves through clinical treatment
Bright, cure rate is up to 95.23%, efficient 100%.And so that its product meat is reached nuisanceless requirement, meet the outlet of product
The health of people has been effectively ensured in standard.Reasonable recipe of the present invention, preparation process is simple, the decoction after decoction, using more
Add conveniently, is absorbed and utilized rapidly.The medicinal herb components of use are from a wealth of sources, at low cost, cure rate is high；Drug noresidue, it is nontoxic
Side effect is easy to laying hen absorption, effectively treats laying hen fatty liver syndrome, curative effect highly significant.
Specific embodiment
Embodiment 1
Composition by weight: 50 parts of Rabdosia lophanthoides, 50 parts of creeping oxalis, 50 parts of polygonum cuspidate, 45 parts of stringy stonecrop, 45 parts of calyx meto, chicken
40 parts of blood rattan, 35 parts of Rhizoma Chuanxiong, 35 parts of Radix Curcumae, 35 parts of potentilla discolor, 35 parts of field thistle, 30 parts of rheum officinale, 30 parts of cassia seed, 30 parts of Rhizoma Atractylodis Macrocephalae,
30 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
Embodiment 2
Composition by weight: 30 parts of Rabdosia lophanthoides, 30 parts of creeping oxalis, 30 parts of polygonum cuspidate, 25 parts of stringy stonecrop, 25 parts of calyx meto, chicken
20 parts of blood rattan, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Curcumae, 15 parts of potentilla discolor, 15 parts of field thistle, 10 parts of rheum officinale, 10 parts of cassia seed, 10 parts of Rhizoma Atractylodis Macrocephalae,
10 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
Embodiment 3
Composition by weight: 40 parts of Rabdosia lophanthoides, 40 parts of creeping oxalis, 40 parts of polygonum cuspidate, 35 parts of stringy stonecrop, 35 parts of calyx meto, chicken
30 parts of blood rattan, 25 parts of Rhizoma Chuanxiong, 25 parts of Radix Curcumae, 25 parts of potentilla discolor, 25 parts of field thistle, 20 parts of rheum officinale, 20 parts of cassia seed, 20 parts of Rhizoma Atractylodis Macrocephalae,
20 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
4 preparation method of embodiment
It matches and weighs by embodiment 1,2 or 3, prepare as follows:
1. after Rabdosia lophanthoides therein, polygonum cuspidate, calyx meto, Caulis Spatholobi, rheum officinale, cassia seed powder are broken into coarse powder, using
The mode of cold-maceration, first by the medicinal material of crushing be put into infuser plus 65% alcohol, be higher by 2 centimetres again after submergence, cover
Lid impregnates 5 days, in dipping process, often should shake or stir, to accelerate to leach.Maceration extract is then taken out, is filtered, and press
The dregs of a decoction are squeezed, resulting pressed liquor is merged with leachate.The dregs of a decoction are placed into infuser, 65% alcohol is added, submerges it
It is higher by 2 centimetres again afterwards, impregnates 5 days again, squeeze the dregs of a decoction again, resulting pressed liquor is merged with leachate.It will impregnate twice
Liquid mixes, and filters to obtain immersion liquid again, is concentrated and removes ethyl alcohol, obtains medical fluid 1.
2. each component is weighed by a kind of raw material proportioning of pharmaceutical composition for treating laying hen fatty liver syndrome, it will wherein
Creeping oxalis, stringy stonecrop, Rhizoma Chuanxiong, Radix Curcumae, potentilla discolor, field thistle, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis smash it through 100 meshes, add 6 times of amount water to impregnate
It 40 minutes, is then placed in decoction pot, decocts 35 minutes, filter out the dregs of a decoction, take filtrate.The dregs of a decoction are added again 6 times of amount water be put into decoction
In pot, decocts 35 minutes, filter out the dregs of a decoction, take filtrate.Filtrate is concentrated after merging twice, obtains medical fluid 2.
3. medical fluid 1 is merged with medical fluid 2, methionine, choline chloride, inositol are weighed according to the ratio, add it to medical fluid 1
In the amalgamation liquid of medical fluid 2, both for a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, 1.29-1.32g/ containing crude drug
ml。
5 instructions of taking of embodiment
1, dose: by embodiment 1, embodiment 2, embodiment 3 respectively with concentrated medicament made from embodiment 4, by every egg
Chicken 3ml is gavaged in two times.For the illness laying hen that can be drunk water, for the ease of drinking, suitable white sugar can be added in medical fluid, it is right
It is taken in the available dropper drop being in a bad way, every laying hen 8-12 drop, twice daily.
2, medication time: daily morning and afternoon is each primary, gavages within two hours after feeding.
3, medicine temperature control system: 40-50 DEG C warmly takes.
Taboo item: treatment duration of medication reinforces feeding management to chicken is suffered from, and guarantees sufficient drinking-water, is fed for soft easy to digest
Feed.
Criterion of therapeutical effect: by a kind of medicine composite for curing laying hen fatty liver syndrome for treating laying hen fatty liver syndrome,
Whether efficacy determination mainly disappears according to laying hen fatty liver syndrome symptom.It takes medicine 10 days as a treatment course, specific curative effect is divided into
Three-level:
Cure: laying hen fatty liver syndrome symptom all disappears；
It improves: laying hen fatty liver syndrome symptom partial disappearance；
Invalid: laying hen fatty liver syndrome symptom is not improved.
In recent years, we treat laying hen fatty liver syndrome 20802 in multiple individual chicken farms, treat a course for the treatment of,
Cure rate 95.23%, effective percentage 100%.
6 clinical effect trial of embodiment
(1) method
The laying hen that laying hen fatty liver syndrome occurs is selected in seven, chicken farm for publishing egg-laying hen fatty liver syndrome altogether
20802, age 168-370 age in days.Chicken will be suffered from and be divided into four groups, respectively of the present invention group, Chinese medicine group, Western medicine group and control group.
Of the present invention group: for by the pharmaceutical composition for treating laying hen fatty liver syndrome obtained by embodiment 3,4.
Chinese medicine group: removal Western medicine part, including each 40 parts of Rabdosia lophanthoides, creeping oxalis, polygonum cuspidate are organized for the present invention, hang down basin
Grass, each 35 parts of calyx meto, 30 parts of Caulis Spatholobi, Rhizoma Chuanxiong, Radix Curcumae, potentilla discolor, each 25 parts of field thistle, rheum officinale, cassia seed, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis
Each 20 parts, twice, medical fluid is merged for decocting, 1.22 grams of the every milliliter contained of the medical fluid after concentration.In two times by every laying hen 3ml
It gavages.For the illness laying hen that can be drunk water, for the ease of drinking, suitable white sugar can be added in medical fluid, for being in a bad way
Available dropper drip clothes, every laying hen 8-12 drop, twice daily.
Western medicine group (selected from herding and the 2003, the 11st phase of animal doctor): 10 g of methionine, V are added in every kilogram of feedEl0
U, VB120.012mg, choline chloride 1g, inositol lg, ten days as a course for the treatment of.
Control group: any drug therapy is not had to.
Treatment time is two courses for the treatment of, and each course for the treatment of is 10 days, and upper and lower noon each medication is primary daily.
(2) result
20802 are suffered from chicken by different dosage regimens, and after the treatment of two courses for the treatment of, the therapeutic effect of each group is shown in Table
2。
From table 2, three groups of drugs have different therapeutic effects to laying hen fatty liver syndrome, wherein with the present invention
Group therapeutic effect is best, and cure rate is significantly higher than other two groups (P < 0.01) up to 95.23%, total effective rate 100.00%；Chinese medicine
Group is taken second place, and again, Chinese medicine group and Western medicine group difference is not significant (P > 0.05), and this two groups extremely aobvious with control group difference for Western medicine group
It writes (P < 0.01), control group does not have therapeutic effect.
It was verified that of the present invention group has Shugan Qingre, the esterified stasis of blood of dispelling, replenishes qi to invigorate the spleen, the function for eliminating the phlegm of stopping blooding, to laying hen rouge
Fat liver syndrome has a good effect.Above-mentioned Chinese and western drugs dialectical compatibility and are mutually assisted through organic assembling, enhance the party
It is soothing the liver dispel rouge the effect of, thus achieve the purpose that cure laying hen fatty liver syndrome.It is combined using Chinese and Western medicine produced by the present invention
Object effect is more obvious, clinical application indicate that, there is special efficacy to treatment laying hen fatty liver syndrome.It counts and demonstrate,proves through clinical treatment
Bright, cure rate is up to 95.23%, efficient 100%.And so that its product meat is reached nuisanceless requirement, meet the outlet of product
The health of people has been effectively ensured in standard.Reasonable recipe of the present invention, preparation process is simple, more convenient to use, absorbs benefit
With rapid.The medicinal herb components of use are from a wealth of sources, at low cost, cure rate is high, and drug noresidue has no toxic side effect, is easy to egg
Chicken absorbs, and effectively treats laying hen fatty liver syndrome, curative effect highly significant.
What above-mentioned reference embodiment carried out pharmaceutical composition of the treatment laying hen fatty liver syndrome and preparation method thereof
Detailed description, is illustrative without being restrictive, can enumerate several embodiments according to limited range, therefore not
The change and modification being detached under present general inventive concept, should belong within protection scope of the present invention.
Claims (6)
1. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, its composition by weight are as follows: 30-50 parts of Rabdosia lophanthoides,
30-50 parts of creeping oxalis, 30-50 parts of polygonum cuspidate, 25-45 parts of stringy stonecrop, 25-45 parts of calyx meto, 20-40 parts of Caulis Spatholobi, Rhizoma Chuanxiong 15-35
Part, 15-35 parts of Radix Curcumae, 15-35 parts of potentilla discolor, 15-35 parts of field thistle, 10-30 parts of rheum officinale, 10-30 parts of cassia seed, Rhizoma Atractylodis Macrocephalae 10-30
Part, 10-30 parts of rhizoma alismatis, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
2. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome according to claim 1, it is characterised in that: it
Composition by weight are as follows: 50 parts of Rabdosia lophanthoides, 50 parts of creeping oxalis, 50 parts of polygonum cuspidate, 45 parts of stringy stonecrop, 45 parts of calyx meto, Caulis Spatholobi 40
Part, 35 parts of Rhizoma Chuanxiong, 35 parts of Radix Curcumae, 35 parts of potentilla discolor, 35 parts of field thistle, 30 parts of rheum officinale, 30 parts of cassia seed, 30 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis 30
Part, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
3. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome according to claim 1, it is characterised in that: it
Composition by weight are as follows: 30 parts of Rabdosia lophanthoides, 30 parts of creeping oxalis, 30 parts of polygonum cuspidate, 25 parts of stringy stonecrop, 25 parts of calyx meto, Caulis Spatholobi 20
Part, 15 parts of Rhizoma Chuanxiong, 15 parts of Radix Curcumae, 15 parts of potentilla discolor, 15 parts of field thistle, 10 parts of rheum officinale, 10 parts of cassia seed, 10 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis 10
Part, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
4. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome according to claim 1, it is characterised in that: it
Composition by weight are as follows: 40 parts of Rabdosia lophanthoides, 40 parts of creeping oxalis, 40 parts of polygonum cuspidate, 35 parts of stringy stonecrop, 35 parts of calyx meto, Caulis Spatholobi 30
Part, 25 parts of Rhizoma Chuanxiong, 25 parts of Radix Curcumae, 25 parts of potentilla discolor, 25 parts of field thistle, 20 parts of rheum officinale, 20 parts of cassia seed, 20 parts of Rhizoma Atractylodis Macrocephalae, rhizoma alismatis 20
Part, 50 parts of methionine, 10 parts of choline chloride, 10 parts of inositol.
5. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, is to be prepared by the following method:
1) a kind of raw material proportioning of pharmaceutical composition for treating laying hen fatty liver syndrome according to claim 1 weighs each group
Part, after Rabdosia lophanthoides, polygonum cuspidate, calyx meto, Caulis Spatholobi, rheum officinale, cassia seed are crushed, the alcohol of 60-70% is added repeatedly to extract,
Merge leachate, filtering removes ethyl alcohol, and concentration obtains medical fluid 1；
2) by creeping oxalis, stringy stonecrop, Rhizoma Chuanxiong, Radix Curcumae, potentilla discolor, field thistle, Rhizoma Atractylodis Macrocephalae, rhizoma alismatis grinding and sieving, decoction filters out medicine
Slag takes filtrate, and concentration obtains medical fluid 2；
3) medical fluid 1 is merged with medical fluid 2, methionine, choline chloride, inositol is added, mixed.
6. a kind of pharmaceutical composition for treating laying hen fatty liver syndrome according to claim 5, it is characterised in that: it
Composition by weight are as follows: a kind of pharmaceutical composition for treating laying hen fatty liver syndrome, 1.29-1.32g/ml containing crude drug.
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| CN107568494A (en) * | 2017-10-23 | 2018-01-12 | 无为县雨露生态农业有限公司 | Poultry seaweed fodder and preparation method thereof |
| CN107581394A (en) * | 2017-10-23 | 2018-01-16 | 无为县雨露生态农业有限公司 | Poultry feed and preparation method thereof |
| CN110680902A (en) * | 2019-11-22 | 2020-01-14 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine composition for treating laying hen fatty liver |
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| CN103007208A (en) * | 2013-01-18 | 2013-04-03 | 四川农业大学 | Traditional Chinese medicine formula for preventing fatty liver hemorrhagic syndrome of broiler chickens |
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| 中西医结合治疗蛋鸡脂肪肝综合征;张加力等;《养禽与禽病防治》;20151005(第10期);第39-40页 * |
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