CN105250782A

CN105250782A - Pharmaceutical composition for treating chronic appendicitis and application thereof

Info

Publication number: CN105250782A
Application number: CN201510779871.2A
Authority: CN
Inventors: 庄小侃
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-13
Filing date: 2015-11-13
Publication date: 2016-01-20

Abstract

The invention relates to a pharmaceutical composition for treating chronic appendicitis and application thereof. The pharmaceutical composition is prepared from, by weight, 20-33 parts of waxgourd seeds, 20-33 parts of waternut herbs, 10-16 parts of seaweed, 6-12 parts of red peony roots, 6-12 parts of fortune eupatorium herbs, 6-12 parts of herbs of coffee senna, 5-10 parts of flosmume, 6-12 parts of rhizoma cyperi, 6-12 parts of ardisiae crenatae radix, 20-33 parts of corn stigma and 11-20 parts of herba portulacae. The pharmaceutical composition for treating the chronic appendicitis has the effects of promoting blood circulation to remove blood stasis, removing obstruction in channels to relieve pain, removing toxin and clearing heat, development of pain and inflammation of chronic appendicitis patients can be relieved, adhesion is reduced, inflammatory pathologic absorption is facilitated, and repeated outbreak of appendicitis is effectively restrained.

Description

A kind of pharmaceutical composition and application thereof for the treatment of chronic appendicitis

Technical field

The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition and application thereof for the treatment of chronic appendicitis.

Background technology

Chronic appendicitis is many to be developed by acute appendicitis protracted course of disease, and a part of morbidity is chronic appendicitis performance.Its pathological change mostly is vermiform appendix wall thickening, intracavity cicatrization, or vermiform appendix is longer and bending, has the foreign bodies such as gastrolith in it, causes vermiform appendix luminal stenosis, and content is discharged and is obstructed, and vermiform appendix cavity pressure increases, mucosa congestion and edema.Emptying being obstructed of vermiform appendix easily brings out actute infection or residual infection, and causes prolonged and repeated outbreak, and the touching difficulty of the state of an illness more.Show as Right Lower Abdomen dull pain, distending pain, sore spot is fixed more, and night is obvious, Relapse rate, and touching difficulty more.Doctor trained in Western medicine takes operative treatment more.But some patients is because fearing operation or taking expectant treatment because of other reasons.Expectant treatment doctor trained in Western medicine is based on antibiotic therapy, and from previous experiences, doctor trained in Western medicine antibiotic exists the defects such as cure rate is low, relapse rate is high in the treatment of chronic appendicitis.

Summary of the invention

In view of antibiotic exists, cure rate is low, the high deficiency of relapse rate, the object of the present invention is to provide a kind of Chinese medicine composition of effective treatment chronic appendicitis.

In order to realize object of the present invention, inventor enters further investigation and persistent exploration on the basis of folk remedy, finally obtains following technical scheme:

Treat a pharmaceutical composition for chronic appendicitis, it is made up of the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 20-33 part, Corm Eleocharitis stalk 20-33 part, Sargassum 10-16 part, Radix Paeoniae Rubra 6-12 part, Herba Eupatorii 6-12 part, Herba cassiae occidentalis 6-12 part, FLOS MUME 5-10 part, Rhizoma Cyperi 6-12 part, Radix Ardisiae Crenatae 6-12 part, Stigma Maydis 20-33 part, Herba Portulacae 11-20 part.

Preferably, the pharmaceutical composition for the treatment of chronic appendicitis described above, it is made up of the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 25-28 part, Corm Eleocharitis stalk 25-28 part, Sargassum 12-14 part, Radix Paeoniae Rubra 8-10 part, Herba Eupatorii 8-10 part, Herba cassiae occidentalis 8-10 part, FLOS MUME 7-9 part, Rhizoma Cyperi 8-10 part, Radix Ardisiae Crenatae 8-10 part, Stigma Maydis 25-28 part, Herba Portulacae 14-16 part.

In the present invention's preferred embodiment, the pharmaceutical composition of described treatment chronic appendicitis is made up of the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 26 parts, Corm Eleocharitis obstruct 26 parts, Sargassum 13 parts, Radix Paeoniae Rubra 9 parts, Herba Eupatorii 9 parts, Herba cassiae occidentalis 9 parts, FLOS MUME 8 parts, Rhizoma Cyperi 9 parts, Radix Ardisiae Crenatae 9 parts, Stigma Maydis 26 parts, Herba Portulacae 15 parts.

The pharmaceutical composition of any one treatment chronic appendicitis above-mentioned, it can be made into oral liquid, granule, tablet, capsule; Preferably, the pharmaceutical composition of any one treatment chronic appendicitis above-mentioned, it is made into oral liquid.

It should be noted that, the raw material that preparation of the present invention adopts in preparation process has following source: Semen Benincasae selects the dry seed of cucurbitaceous plant Fructus Benincasae Benincasahispida (Thunb.) Cogn..Corm Eleocharitis stalk selects the dry aerial parts of sedge Corm Eleocharitis Heleo-charisdulcis (Burm.F.) Trin.ExHenschel.Sargassum selects the dry frond of Sargassaceae plant Sargassum fusiforme (Harv.) Setch Sargassumfusiforme (Harv.) Setch..Radix Paeoniae Rubra selects the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall.Herba Eupatorii selects the dry aerial parts of feverfew Herba Eupatorii EupatoriumfortuneiTurcz..Herba cassiae occidentalis selects the dry seed of species Cassia platymiscium Herba cassiae occidentalis CassiaoccidentalisL..FLOS MUME selects the dried floral of Armeniaca Mume of Rosaceae platymiscium FLOS MUME PrunusmumeSieb.etZucc.var.viridicalyxMakino.Rhizoma Cyperi selects the dry rhizome of sedge dried tuber CyperusrotundusL..Radix Ardisiae Crenatae selects the dry root of Myrsinacea Ardisa plant knuckle-tooth Herba Ardisiae Japonicae ArdisiacrenataSims..Stigma Maydis selects style and the fresh idea of grass family Zea plant Zea mays ZeamaysL..Herba Portulacae selects the dry herb of portulacaceous plant Herba Portulacae PortulacaoleraceaL..

In addition, the preparation method above-mentioned each traditional Chinese medicinal material raw materials being prepared into oral liquid of the present invention is:

(1) get the Semen Benincasae of recipe quantity, Corm Eleocharitis stalk, Sargassum, Radix Paeoniae Rubra, Herba Eupatorii, Herba cassiae occidentalis, FLOS MUME, Rhizoma Cyperi, Radix Ardisiae Crenatae, Stigma Maydis and Herba Portulacae, pulverize;

(2) above-mentioned graininess medical material is added water cover powder again, soak 0.8-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-12 times amount, decoct 1-1.5h, get decocting liquid, filter, second time adds up the water of medical material 8-10 times amount, decoct 0.8-1.2h, get twice decocting liquid to merge, filter, concentrated;

(3) concentrated solution is put 2-5 DEG C of deepfreeze 10-40h, cold preservation liquid is added the filter aid kieselguhr of 0.1%-0.5%, filter, filtrate reconcentration contains 1-3g crude drug amount to every milliliter, put 2-5 DEG C of deepfreeze 10-40h, cold preservation liquid is filtered, adds or pack after not adding correctives and obtain oral liquid.

Compared with prior art, all medicine compatibilities of the present invention, have effect of blood circulation promoting and blood stasis dispelling, analgesic, toxin expelling heat clearing away, the pain of energy relieve chronic Appendicitis Patients and the development of inflammation, reduce adhesion, promote that inflammatory lesion absorbs, effectively suppress typhlitic recurrent exerbation.

Detailed description of the invention

Be below specific embodiments of the invention, technical scheme of the present invention and technique effect are done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.

The preparation of embodiment 1 Chinese medicine oral liquid

Take Semen Benincasae 2.6kg, Corm Eleocharitis stalk 2.6kg, Sargassum 1.3kg, Radix Paeoniae Rubra 0.9kg, Herba Eupatorii 0.9kg, Herba cassiae occidentalis 0.9kg, FLOS MUME 0.8kg, Rhizoma Cyperi 0.9kg, Radix Ardisiae Crenatae 0.9kg, Stigma Maydis 2.6kg and Herba Portulacae 1.5kg, pulverize, merge, again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction fill with in decoct with water 2 times, add up the water of medical material 12 times amount for the first time, decoct 1.5h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decoct about 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15, concentrated solution is put 3-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 1.5g crude drug amount, puts 3-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, packs and obtain oral liquid.

The preparation of embodiment 2 Chinese medicine oral liquid

Take Semen Benincasae 3.3kg, Corm Eleocharitis stalk 2.5kg, Sargassum 1.6kg, Radix Paeoniae Rubra 1.2kg, Herba Eupatorii 1.0kg, Herba cassiae occidentalis 1.0kg, FLOS MUME 0.8kg, Rhizoma Cyperi 1.2kg, Radix Ardisiae Crenatae 0.8kg, Stigma Maydis 3.3kg, Herba Portulacae 2.0kg, pulverize, merge, again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extraction fill with in decoct with water 2 times, add up the water of medical material 10 times amount for the first time, decoct 1h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15, concentrated solution is put 3-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 1.5g crude drug amount, puts 3-5 DEG C of deepfreeze 24h to every milliliter, is filtered by cold preservation liquid, adds correctives and packs and obtain oral liquid.

Embodiment 3 Chinese medicine is to the Therapy study of chronic appendicitis patients

Chronic appendicitis patients 58 example, has typical acute appendicitis medical history, leaves over right lower abdomen pain.Filling of appendix also has tenderness, or does not fill but have the tenderness changed with caecum position; Irregular filling of appendix, fixes in point nodular or distortion; Filling of appendix but emptying slow (more than 48h).Wherein, man 31 example, female 27 example; 39 ~ 60 years old age, average (51.6 ± 3.9) year; The course of disease 7 ~ 13 months, average (8.5 ± 1.1) individual month.All patients are divided into two groups at random, test group and matched group each 29 example, two groups in sex, age, the course of disease etc. through statistical procedures, no significant difference, has comparability.

After on-test, the oral cefalexin Tablet of matched group patient, each 0.5g; Metronidazole Tablet, each 0.4g, is every day 3 times.The oral Chinese medicine oral liquid of the present invention of test group patient (preparing by the formulation and technology of embodiment 1), respectively takes 50ml sooner or later.Two groups all serve on observe the curative effect after 15d, and criterion of therapeutical effect is as follows: clinical recovery: pain disappears, and local tenderness disappears, no conscious sympton.Effective: subjective symptoms obviously alleviates, Right Lower Abdomen tenderness alleviates.Invalid: symptom, sign are without obviously alleviating.Can be found out by the clinical efficacy statistical result of table 1, test group total effective rate 89.7%, matched group total effective rate 72.4%, test group clinical efficacy is better than matched group, and especially clinical recovery rate test group is apparently higher than matched group.In addition, treatments period, test group has no adverse reaction, epigastric discomfort after taking medicine appears in matched group 4 example.

Table 1 liang group comparitive study (example)

Choose two groups of clinical recovery cases and follow up a case by regular visits to 3 months, observe recurrence.Recur 2 examples in test group 17 example, relapse rate is 11.8%; Recur 6 examples in matched group 10 example, relapse rate is 60.0%, and test group relapse rate is starkly lower than matched group.

Claims

1. treat a pharmaceutical composition for chronic appendicitis, it is characterized in that: this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 20-33 part, Corm Eleocharitis stalk 20-33 part, Sargassum 10-16 part, Radix Paeoniae Rubra 6-12 part, Herba Eupatorii 6-12 part, Herba cassiae occidentalis 6-12 part, FLOS MUME 5-10 part, Rhizoma Cyperi 6-12 part, Radix Ardisiae Crenatae 6-12 part, Stigma Maydis 20-33 part, Herba Portulacae 11-20 part.

2. treat the pharmaceutical composition of chronic appendicitis according to claim 1, it is characterized in that: this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 25-28 part, Corm Eleocharitis stalk 25-28 part, Sargassum 12-14 part, Radix Paeoniae Rubra 8-10 part, Herba Eupatorii 8-10 part, Herba cassiae occidentalis 8-10 part, FLOS MUME 7-9 part, Rhizoma Cyperi 8-10 part, Radix Ardisiae Crenatae 8-10 part, Stigma Maydis 25-28 part, Herba Portulacae 14-16 part.

3. treat the pharmaceutical composition of chronic appendicitis according to claim 2, it is characterized in that: this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Benincasae 26 parts, Corm Eleocharitis obstruct 26 parts, Sargassum 13 parts, Radix Paeoniae Rubra 9 parts, Herba Eupatorii 9 parts, Herba cassiae occidentalis 9 parts, FLOS MUME 8 parts, Rhizoma Cyperi 9 parts, Radix Ardisiae Crenatae 9 parts, Stigma Maydis 26 parts, Herba Portulacae 15 parts.

4. according to claim 1 or 2 or 3, treat the pharmaceutical composition of chronic appendicitis, it is characterized in that: described Herba cassiae occidentalis selects the dry seed of species Cassia platymiscium Herba cassiae occidentalis CassiaoccidentalisL..

5. according to claim 1 or 2 or 3, treat the pharmaceutical composition of chronic appendicitis, it is characterized in that: described pharmaceutical composition is oral formulations, described oral formulations comprises oral liquid, granule, Tablet and Capsula agent.

6. the application of the traditional Chinese medicinal material raw materials compositions according to claim 1 or 2 or 3 in the medicine of preparation treatment chronic appendicitis.