CN105237377B - The technique that silica gel method extracts germacrone from thymeleaf rhododendron herb leaf - Google Patents
The technique that silica gel method extracts germacrone from thymeleaf rhododendron herb leaf Download PDFInfo
- Publication number
- CN105237377B CN105237377B CN201510719269.XA CN201510719269A CN105237377B CN 105237377 B CN105237377 B CN 105237377B CN 201510719269 A CN201510719269 A CN 201510719269A CN 105237377 B CN105237377 B CN 105237377B
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- CN
- China
- Prior art keywords
- germacrone
- petroleum ether
- thymeleaf
- rhododendron
- herb leaf
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (3)
- It is to crush thymeleaf rhododendron herb leaf, using water vapour 1. silica gel method extracts the technique of germacrone from thymeleaf rhododendron herb leaf The way of distillation extracts 5 ~ 8h and obtains volatile oil;It is added to after volatile oil is dehydrated with anhydrous sodium sulfate again in 160~200 mesh silicagel columns, Eluted, collection portion shunts part, crystallized as eluent with ethyl acetate mixed solvent with petroleum ether petroleum ether, filtering, so Crystallized, then with petroleum ether dissolution and recrystallized with petroleum ether afterwards, refiltered, washed, obtain high-purity germacrone.
- 2. the technique that silica gel method as claimed in claim 1 extracts germacrone from thymeleaf rhododendron herb leaf, it is characterised in that:Murraya paniculataJack Rhododendron leaves are ground into powder for 40~60 mesh.
- 3. the technique that silica gel method as claimed in claim 1 extracts germacrone from thymeleaf rhododendron herb leaf, it is characterised in that:It is described to wash The volume ratio of de- liquid petroleum ether and ethyl acetate in the mixed solvent, petroleum ether and ethyl acetate is 200:1~50:1.
Priority Applications (1)
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CN201510719269.XA CN105237377B (en) | 2015-10-30 | 2015-10-30 | The technique that silica gel method extracts germacrone from thymeleaf rhododendron herb leaf |
Applications Claiming Priority (1)
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CN201510719269.XA CN105237377B (en) | 2015-10-30 | 2015-10-30 | The technique that silica gel method extracts germacrone from thymeleaf rhododendron herb leaf |
Publications (2)
Publication Number | Publication Date |
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CN105237377A CN105237377A (en) | 2016-01-13 |
CN105237377B true CN105237377B (en) | 2017-10-13 |
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CN201510719269.XA Expired - Fee Related CN105237377B (en) | 2015-10-30 | 2015-10-30 | The technique that silica gel method extracts germacrone from thymeleaf rhododendron herb leaf |
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CN (1) | CN105237377B (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101973861A (en) * | 2010-07-26 | 2011-02-16 | 南京泽朗医药科技有限公司 | Method for preparing germacrone |
RU2436771C1 (en) * | 2010-08-06 | 2011-12-20 | Государственное образовательное учреждение высшего профессионального образования "Белгородский государственный университет" | Method of extracting xanthophylls from plant material |
CN103330700A (en) * | 2013-06-26 | 2013-10-02 | 深圳海王药业有限公司 | Application of germacrone in preparing HSV (Herpes Simplex Virus) resisting medicine |
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- 2015-10-30 CN CN201510719269.XA patent/CN105237377B/en not_active Expired - Fee Related
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CN105237377A (en) | 2016-01-13 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Liang Junyu Inventor after: Kong Weibao Inventor after: Zhang Lijuan Inventor after: Zhang Xinxin Inventor after: Zhu Jieni Inventor after: Zhou Jiaxin Inventor after: Wang Mengzhen Inventor after: Yu Jinyan Inventor after: Li Lingyan Inventor after: Wang Junlong Inventor before: Liang Junyu Inventor before: Wang Wenting Inventor before: Zheng Yanfei Inventor before: Qin Juan Inventor before: Ma Yingxiong Inventor before: Zhang Ji Inventor before: Wang Junlong Inventor before: Kong Weibao |
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CB03 | Change of inventor or designer information | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171013 Termination date: 20211030 |
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CF01 | Termination of patent right due to non-payment of annual fee |