CN105233347B - A kind of medical porous metal tissue scaffold design in 3D printing gradient aperture - Google Patents
A kind of medical porous metal tissue scaffold design in 3D printing gradient aperture Download PDFInfo
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- CN105233347B CN105233347B CN201510725398.XA CN201510725398A CN105233347B CN 105233347 B CN105233347 B CN 105233347B CN 201510725398 A CN201510725398 A CN 201510725398A CN 105233347 B CN105233347 B CN 105233347B
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Abstract
The invention discloses a kind of medical porous metal tissue scaffold designs in 3D printing gradient aperture, it is intended to the microcellular structure of the single repetition of the prior art is overcome to be unfavorable for bone tissue and grow into, the problem of bone tissue implant is difficult to reach bony union with itself bone, its generally hexahedron structure, it is made of component A, component B and component C close-packed arrays, component A arrays are in hexahedron structure outermost layer, and component B arrays are in secondary outer layer, and component C arrays are in innermost layer；Component A, component B, component C are hexahedron frame structure, and the aperture of component A is more than the aperture of component B, and the aperture of component B is more than the aperture of component C.The present invention is designed by reinforcement structure, makes the tissue engineered bone stent of hole gradual change, is regulated and controled bone tissue and growing into fiber etc. by the hole of gradual change in gradient, is finally reached optimal knitting.
Description
Technical field
The present invention relates to a kind of 3D printing medical metal implantation materials, and in particular to a kind of 3D printing gradient aperture is medical porous
Metal tissue scaffold design is conducive to bone tissue and grows into, and promotes bony union.
Background technology
It is significant for the development of tissue engineered bone that 3D printing prepares porous metals, reduces because of autologous bone transplanting pair
Damage caused by patient body, while also avoid the high cost issues of allogenic bone transplantation.Sweden Arcam passes through 3D printing skill
The orthopaedics implants such as metal alloy mortar cup, femoral shaft, backbone and the skull that art is successfully prepared, which part porous metals alloy bone
Implantation material is repaired to be applied in clinic.
Porous metals printing is mainly using such as Sweden Arcam companies rely on electron-beam smelting (EBM) 3D printing skill at present
The porous metals of art manufacture can accurately control micropore size, porosity, duct trend and unicom feelings by computer design structure
Condition, aperture minimum can reach 400 microns, and porosity is maximum up to 85%.And selective laser melting technique (SLM) can reach
It, can be with more precise control timbering material internal structure to higher precision (100 microns).
And 3D printing micropore is single now, is mostly the repetition of single structure, the often aperture of fixed size and single
Duct unicom structure, and this is not consistent with body bone tissue trabecular bone structure, and be unfavorable for bone tissue and grow into, easily cause bone group
It knits and is grown into simultaneously into fiber, substantial amounts of fibr tissue causes fiber healing rather than knitting.And it as tissue is grown into, necessarily needs
Want the space of creeping of bigger, and traditional design scheme also results in bone tissue grows into the later stage and the problem of growing space is insufficient occur.
EBM or SLM can precisely enough control internal structure, but the attention to structure design at present and inadequate, inabundant hair
The advantage that 3D printing accurately controls internal structure is waved, the structure of single repetition is unfavorable for knitting.
The content of the invention
It is an object of the invention to which the microcellular structure of the single repetition of the prior art is overcome to be unfavorable for bone tissue to grow into, bone tissue
The problem of implantation material is difficult to reach bony union with itself bone provides a kind of 3D printing gradient aperture medical porous metal bone tissue
Stent, reinforcement structure design make the tissue engineered bone stent of hole gradual change, regulate and control bone tissue by the hole of gradual change in gradient
And growing into fiber etc., it is finally reached optimal knitting.
The present invention is achieved by the following scheme：
A kind of medical porous metal tissue scaffold design in 3D printing gradient aperture, generally hexahedron structure, by component A,
Component B and component C close-packed arrays composition, component A arrays are in hexahedron structure outermost layer, and component B arrays are in secondary outer layer, component C
Array is in innermost layer；Component A, component B, component C are hexahedron frame structure, and the aperture of component A is less than the hole of component B
Footpath, the aperture of component B are less than the aperture of component C.
The medical porous metal tissue scaffold design in a kind of 3D printing gradient aperture, wherein, component C is by support column and draws
Guide rod is formed, and a plurality of support column connects and composes the arris of hexahedron frame structure, and guiding bar is located at hexahedron frame structure per phase
To the line of centres in two faces, the guiding bar of adjacent component interconnects；Component A and component B is by support column, guiding bar and divides
Barrier is formed, and grille is located at the diagonal positions in each face of hexahedron frame structure, and the quantity of grille is less than in component B
The quantity of grille in component A.
The medical porous metal tissue scaffold design in a kind of 3D printing gradient aperture, wherein, the number of grille in component B
It measures as the half of the quantity of grille in component A.
The medical porous metal tissue scaffold design in a kind of 3D printing gradient aperture, wherein, hexahedron frame in component A
The each face of structure is equipped with two grilles, and only sets a grille in component B on each face of hexahedron frame structure.
Compared with prior art, the present invention has the following advantages：
The present invention the fine structure of redesign 3D printing metal tissue scaffold design, 3 kinds of different components are designed, according to different
The variation of the arrangement adjustment hole of component, each component include support column, grille and guiding bar composition respectively.The present invention can be with
By adjusting the length of support column, and then change the length of grille successively, so as to change pore area so that change aperture it is big
It is small.Therefore the present invention can simply and easily adjust aperture.
Tissue scaffold design of the present invention, in order to achieve the purpose that hole gradual change, devises separation based on hexahedron structure
Grid change the aperture of hole with grille.
The present invention in order to which cell tissue is promoted to creep, exemplified by tissue scaffold design devise guiding bar, it is thin to play guiding emphatically
The effect that born of the same parents' migration is creeped.It is more advantageous to bone tissue to grow into metallic support along guiding bar direction, make tight between tissue and stent
Close combination, achievees the purpose that bony union.
The present invention is the medical porous metal tissue scaffold design in gradient aperture of aperture gradual change, is conducive to cell tissue and closes in order
Reason is grown into inside metal tissue scaffold design.Support column, grille, the length of guiding bar can be adjusted, and drive simultaneously
Pore size changes, and method is simple and effective, can produce the gradual change hole metal tissue scaffold design of different pore size gradient.
Description of the drawings
Fig. 1 is the overall structure simplified schematic diagram of the medical porous metal tissue scaffold design in 3D printing gradient aperture of the present invention；
Fig. 2 is that the present invention builds gradient pore structured component A structure diagrams.
Fig. 3 is that the present invention builds gradient pore structured component B structure schematic diagram.
Fig. 4 is that the present invention builds gradient pore structured component C-structure schematic diagram.
In figure:
1- support columns, 2- grilles, 3- guiding bars.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.Attached drawing is simplified schematic diagram, only with signal
Mode illustrates the basic structure of the present invention, therefore it only shows composition related to the present invention.
Fig. 1 show the structure diagram of the medical porous metal tissue scaffold design in 3D printing gradient aperture, and the stent is complete
Structure is hexahedron structure, and Fig. 1 omits view for part, only retains three mutually orthogonal alien invasions, and Fig. 2 to Fig. 4 is composition
Three kinds of components of the stent.The medical porous metal tissue scaffold design in 3D printing gradient aperture is by component A, component B and component C groups
Into component A, component B, component C are located at the outer middle inner layer surface of stereochemical structure respectively, i.e. component A arrays provide minimum in outermost layer
Aperture, component B arrays provide intermediate aperture, component C arrays provide maximum diameter of hole, i.e. component A holes in innermost layer in secondary outer layer
Footpath is less than the aperture of component B, and the aperture of component B is less than the aperture of component C.
In the present embodiment, which is the six rank cube structures of 6*6*6, and component A is distributed on cube structure outermost one
Layer, component B are distributed on outside secondary one layer, and component C is distributed on innermost layer two layers.
Component A, component B, component C are hexahedron frame structure, and component C is made of support column 1 and guiding bar 3, more
Support column 1 connects and composes the arris of hexahedron frame structure；Component A and component B is by support column 1, guiding bar 3 and grille 2
It forms, and the quantity of grille 2 is less than the quantity of grille 2 in component A in component B.
Support column 1 is the arris of hexahedron frame structure, and it is medical that each support column 1 is interconnected to constitute 3D printing gradient aperture
The main body stereochemical structure of porous metals tissue scaffold design.
Grille 2 is located at the diagonal positions in each face of hexahedron frame structure, for splitting metal tissue scaffold design
Hole can divide the apertures into large, medium and small three kinds by the quantity for controlling grille.In the present embodiment, the area of component A and component B
It is not, two grilles 2 is set in component A on hexahedral each face, and is only set on hexahedral each face in component B
A piece grille 2.
Guiding bar 3 is component A, component B, the shared ingredient of component C, positioned at hexahedron frame structure often with respect to two faces
The line of centres, the guiding bar 3 of adjacent component interconnect, and guiding role is provided for growing into for cell tissue.In Fig. 1 in order to avoid
Number of lines is excessive, and guiding bar 3 is not shown.
Present invention 3D printing metal tissue scaffold design different from the past, is improved on conventional stereo architecture basics, makes
Metal tissue scaffold design has the characteristic of hole gradual change.
As shown in Figure 1 by taking regular hexahedron metal tissue scaffold design as an example, if 1 length of support column is 1.4mm, the stent is outermost
One layer is made of component A, the pore area 0.49mm in component A2, then hole effective aperture is about 400um.Secondary outer layer is by component
B is formed, pore area 0.98mm2, then effective aperture is about 560um.Innermost layer is made of component C, and pore area is
1.96mm2, then effective aperture is 790um.
If 1 length of support column is 2mm, outermost one layer of the stent is made of component A, the pore area 1mm in component A2, then
Hole effective aperture is about 556um.Secondary outer layer is made of component B, pore area 2mm2, then effective aperture is about 798um.Most
Internal layer is made of component C, pore area 4mm2, then effective aperture can be by adjusting support column for the visible present invention of 1120um
1 length and then adjusting hole gap varying aperture, method is simple and effective, and can achieve the purpose that aperture gradual change with reference to grille 2.
In order to preferably bone tissue be promoted to grow into, the present invention devises guiding bar 3, when histocyte crawls into metal bone group
It when knitting stent outermost surface, can creep along guiding bar 3, be conducive to cell migration, and then bone tissue is promoted to grow into.Guiding bar
3 can be adjusted choice according to the position for being put into bone defect, retain with the bone guiding bar that grow into direction consistent, climb cell
Row, which is grown into, more meets human body natural's bone tissue direction.
Claims (3)
1. a kind of medical porous metal tissue scaffold design in 3D printing gradient aperture, which is characterized in that its generally hexahedron structure,
It is made of component A, component B and component C close-packed arrays, component A arrays are in hexahedron structure outermost layer, and component B arrays are in secondary outer
Layer, component C arrays are in innermost layer；Component A, component B, component C are hexahedron frame structure, and the aperture of component A is less than group
The aperture of part B, the aperture of component B are less than the aperture of component C；The component C is made of support column (1) and guiding bar (3), a plurality of
Support column (1) connects and composes the arris of hexahedron frame structure, and guiding bar (3) is located at hexahedron frame structure often with respect to two faces
The line of centres, the guiding bar (3) of adjacent component interconnects；Component A and component B by support column (1), guiding bar (3) and
Grille (2) is formed, and grille (2) is located at the diagonal positions in each face of hexahedron frame structure, and grille in component B
(2) quantity is less than the quantity of grille (2) in component A.
A kind of 2. medical porous metal tissue scaffold design in 3D printing gradient aperture as described in claim 1, which is characterized in that institute
State half of the quantity of grille (2) in component B for the quantity of grille (2) in component A.
A kind of 3. medical porous metal tissue scaffold design in 3D printing gradient aperture as described in claim 1, which is characterized in that institute
It states each face of hexahedron frame structure in component A and is equipped with two grilles (2), and hexahedron frame structure is each in component B
A grille (2) is only set on face.
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| CN107198600A (en) * | 2016-03-18 | 2017-09-26 | 重庆润泽医药有限公司 | A kind of interbody spinal implant |
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| CN105919696A (en) * | 2016-05-04 | 2016-09-07 | 宁波傲骨生物科技有限公司 | Preparation method of bionic artificial bone scaffold having mechanical gradient |
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| CN107647943A (en) * | 2017-11-02 | 2018-02-02 | 广州华钛三维材料制造有限公司 | A kind of metal bone trabecula and the skeleton implant for including the metal bone trabecula |
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