CN105232013A - Noninvasive vascular endothelial function assessment device - Google Patents
Noninvasive vascular endothelial function assessment device Download PDFInfo
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- CN105232013A CN105232013A CN201510655373.7A CN201510655373A CN105232013A CN 105232013 A CN105232013 A CN 105232013A CN 201510655373 A CN201510655373 A CN 201510655373A CN 105232013 A CN105232013 A CN 105232013A
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Abstract
The invention relates to the technical field of noninvasive vascular endothelial function measurement and provides a noninvasive vascular endothelial function assessment device. The noninvasive vascular endothelial function assessment device comprises three blood pressure cuffs, a cuff pressure control unit, an inflator pump, two pressure sensors, a signal conditioning and A/D (analog to digital) acquisition circuit, a data processing unit and a display module. Each blood pressure cuff is provided with an independent intake passage with an intake valve and an exhaust passage with an exhaust valve, the intake passage of each blood pressure cuff is connected with the inflator pump, and the inflator pump, each intake valve and each exhaust valve are controlled by the cuff pressure control unit; two pressure sensors are arranged in the exhaust passages of two of the blood pressure cuffs respectively, the two pressure sensors are connected with the signal conditioning and A/D acquisition circuit which is connected with the data processing unit, and the data processing unit is connected with the display module. By the noninvasive vascular endothelial function assessment device, vascular endothelial function measurement based on noninvasive measurement for aortas of both arms can be realized.
Description
Technical field
The invention belongs to technical field of biomedical detection, be specifically related to the noinvasive vascular endothelial function measuring device measured based on both arms vascular pressure.
Background technology
Blood vessel endothelium is the monolayer being covered in vascular inner surface, and normal vascular endothelial function is the primary condition maintaining cardiovascular system stable state.Vascular endothelium dysfunction has been proved to be and has there is multiple contacting closely with many diseases or its diagnosis marker.Current endothelial function detection means is mainly divided into invasive to detect and Noninvasive FMD endothelium detects.Invasive detects the change that can be detected arteria coronaria caliber and flow by angiography, and judges endothelial function with this.But because of its invasive, and consuming time longer, costly, clinical practice is extremely restricted.Noninvasive FMD endothelium detects and adopts the method for cuff pressurization to block brachial artery flow number minute, rapid decompression afterwards, thus make blood flow form higher blood flow shearing stress to endothelium, make vasodilation with this stimulating endothelial release nitric oxide, simultaneously utilize the change of ultrasonic probe to single vessel caliber to measure in above process and the assessment of endothelial function.Because interference caliber change etc. because the factors such as temperature, psychology, nerve cause can not be evaded, cause detecting repeatability and data reliability low.
At present, Endo-PAT adopts peripheral arterial tonometry (i.e. the detection of blood flow) to measure the change of finger tip arteriopalmus volume.The Vascular change interference that this measuring method causes by contrasting two groups of factors such as signals eliminating environment, psychology etc. is the noinvasive vascular endothelial function diagnostic system of unique acquisition U.S. FDA certification at present.But its measuring point is the forefinger front end of both hands, gained signal reaction be the vascular endothelial function of tremulous pulse end, and aortal endothelial function can not be replaced.For this reason, the present invention is measured as target with aorta, devises the vascular endothelial function apparatus for evaluating measured based on both arms vascular pressure.
Summary of the invention
The object of the invention is to provide a kind of noninvasive vascular endothelial function apparatus for evaluating, and it can realize the assessment of the noinvasive vascular endothelial function measured based on both arms vascular pressure, solves the deficiency having wound measuring method at present.Compare based on acral vascular endothelial function non-invasive measurement, the method is measured based on both arms aorta, measures and is applicable to assessment vascular endothelial function.The present invention is particularly suitable for measurement and the assessment of noninvasive aorta vessel endothelial function, such as, apply for hospital clinical.
For achieving the above object, the noninvasive vascular endothelial function apparatus for evaluating of one provided by the invention, comprise three blood pressure cuffs, cuff air pressure control unit, inflator pump, two pressure transducers, signal condition and A/D Acquisition Circuit, data processing unit and display modules, each blood pressure cuff all has independently with the inlet channel of intake valve and the exhaust passage with air bleeding valve, the inlet channel of each blood pressure cuff is connected with inflator pump, and inflator pump, each intake valve and air bleeding valve are controlled by cuff air pressure control unit; Be respectively equipped with pressure transducer in the exhaust passage of wherein two blood pressure cuffs, two pressure transducer connection signals conditionings and A/D Acquisition Circuit, signal condition and A/D Acquisition Circuit connection data processing unit, data processing unit connects display module.
Described blood pressure cuff is stiff arms cuff, in three blood pressure cuffs, two blood pressure cuffs for binding left and right two arms, and by arm vascular pressure by conduit to respective pressure transducer; Blocker arm blood flow is inflated when another blood pressure cuff is for measuring.
Described cuff air pressure control unit controls inflator pump, each intake valve, each exhaust valve operation, quantitatively inflates, air pressure keeps and Rapid degassing to each blood pressure cuff.
The signal condition functional realiey two-way pressure transducer of described signal condition and A/D Acquisition Circuit exports amplification and the Filtering Processing of small-signal, and A/D sampling functions realizes the analog/digital conversion of signal and real-time sampling.
Described intake valve and air bleeding valve are electronic control valve.
Described data processing unit realizes Parameter analysis and the calculating of cuff pressure data prediction and the assessment vascular endothelial function obtained sampling.Display module is for two-way cuff pressure waveform during display measurement and Calculation results.During measurement, cuff air pressure control unit, according to the flow process of setting, opens or closes the corresponding inlet channel of cuff and exhaust passage by electronic control valve, is completed the inflation of blood pressure cuff by inflator pump.Blood pressure cuff keeps the stage that arm vascular pressure is transferred to respective pressure transducer by gas conduit at air pressure; Conditioning and the real-time sampling of pressure sensor signal is completed by signal condition and A/D Acquisition Circuit; Data carry out process by data processing unit and parameter calculates, and are shown by display module.
The present invention compared with prior art has the following advantages:
1) compared with existing noninvasive measuring method, measuring point adopts upper arm aorta to measure the acral measurement of replacement, and measurement result is more reasonable; By contrasting the Vascular change interference that two groups of factors such as signals eliminating environment, psychology etc. cause, improve repeatability and the reliability of system.
2) compared with the measuring method having wound, more convenient, practical, risk is little.
Accompanying drawing explanation
Fig. 1 is the functional block diagram of a kind of noninvasive vascular endothelial function apparatus for evaluating of the present invention.
Fig. 2 is that the present invention realizes noninvasive vascular endothelial function measurement estimation flow figure.
Fig. 3 is the data shape figure of both arms cuff pressure change real-time sampling.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.First composition graphs 1, Fig. 2 and detailed description of the invention are described in detail the noninvasive vascular endothelial function apparatus for evaluating of the present invention.
Fig. 1 shows the Main functional units of vascular endothelial function apparatus for evaluating of the present invention, comprise inflator pump (101), blood pressure cuff A(102), blood pressure cuff B(103), blood pressure cuff C(104), pressure transducer A(105), pressure transducer B(106), the intake valve A(107 of blood pressure cuff A), air bleeding valve A(108), the intake valve B(109 of blood pressure cuff B), air bleeding valve B(110), the intake valve C(111 of blood pressure cuff C), air bleeding valve C(112), cuff air pressure control unit (113), signal condition and A/D Acquisition Circuit (114), data processing module (115) and display module (116).Blood pressure cuff A(102), blood pressure cuff B(103) complete inflation by inflator pump (101) by gas conduit; Intake valve A(107) and air bleeding valve A(108) realize to blood pressure cuff A(102) inflation, keep air pressure and Quick air-discharge operation; Intake valve B(109) and air bleeding valve B(110) realize to blood pressure cuff B(103) inflation, keep air pressure and Quick air-discharge operation; Intake valve A(107), air bleeding valve A(108), intake valve B(109), air bleeding valve B(110) realized by electronic control valve, and to be completed by cuff air pressure control unit (113) programming Control; Blood pressure cuff A(102), blood pressure cuff B(103) be bundled in left and right two arms respectively, and by vascular pressure by conduit to pressure transducer A(105), pressure transducer B(106); Pressure transducer A(105), pressure transducer B(106) pressure signal is converted to current signal and completes by signal condition and A/D Acquisition Circuit (114) dynamic value that two-arm vascular pressure changes and sample; Two groups of vascular pressure delta datas, by data processing module (115) computing, show intermediate data and parametric results by display module (116).
Fig. 2 shows the main measurement procedure of the present invention's noninvasive vascular endothelial function apparatus for evaluating, measures and mainly completes in three steps.
Before measurement, by blood pressure cuff A(102) and blood pressure cuff B(103) be bundled in the upper arm of left and right two handss of experimenter respectively, for after the pressurizing arm vascular pressure being transferred to pressure transducer.Blood pressure cuff C(104) be bundled in the underarm of a wherein arm, for blocker arm blood flow after the pressurizing.
First measuring process: the calibration completing measuring system between both arms.
Calibration process comprises two measuring phases: 1) calculate at cuff without pressure condition lower pressure sensor A(105), pressure transducer B(106), the datum drift of signal condition and A/D Acquisition Circuit (114).2) calculate at cuff actual measurement condition lower pressure sensor A(105), pressure transducer B(106), the amplitude multiplying power of signal condition and A/D Acquisition Circuit (114).
Therefore, first needed all cufves without press operation (201), afterwards continuous acquisition two-way sensing data (202), and two-way sensing data has been shown in real time and is recorded as <V10, V11>(203).
Second measuring process: measurement arm is at blood pressure cuff C(104) pressurize blocking blood flow time and blocking blood flow after vascular pressure change; And record the vascular pressure change of another arm.
Therefore, first needed blood pressure cuff C(104) with no pressure, blood pressure cuff A(102), blood pressure cuff B(103) have the operation (211) of certain pressure, continuous acquisition two-way sensor has pressure condition data (212) afterwards, and two-way sensing data is shown in real time and is recorded as <V20, V21>(213).
3rd measuring process: calculate cuff C(104) the endothelial function evaluate parameter of after the aerofluxus moment 1 minute, 2 minutes and 5 minutes, and exported by display module.
Therefore, at blood pressure cuff A(102), blood pressure cuff B(103) certain pressure basis on, keep cuff A, B pressure (221), and to cuff C(104) the straight arm bloodstream blocking of pressurization (222), continuous acquisition two-way sensing data (223) afterwards, and two-way sensing data is shown in real time and is recorded as <V30, V31>(224); Last by <V10, V11>, <V20, V21> and <V30, V31> tri-groups of data, calculate assessment result (225).
Below in conjunction with Fig. 3, noninvasive vascular endothelial function apparatus for evaluating sampled data aspect graph and assessment result are described.
In Fig. 3, vertical coordinate is for representing the magnitude of voltage of cuff pressure, and abscissa measures the time of sampling for representing.The vascular pressure sampled data that the waveform (31) of sampled data composition is arm when blood pressure cuff gas pressure remains 20mmHg, the Vascular change caused for contrasting and get rid of the factor such as environment, psychology disturbs; The vascular pressure sampled data that the waveform (32) of sampled data composition is another arm when blood pressure cuff gas pressure remains 20mmHg, wherein, the first stage (301) is blood pressure cuff C(104) stage of unaerated; Second stage (302) is blood pressure cuff C(104) be inflated to when air pressure is 180mmHg for the blocker arm blood flow stage; Phase III (303) is blood pressure cuff C(104) venting after whole process.From blood pressure cuff C(104) timing node of the aerofluxus moment (30) 1 minute, 2 minutes and 5 minutes, calculate the proportionate relationship change between data (31) and data (32), generation endothelial function evaluate parameter.
embodiment 1
Inflator pump (101) is connected respectively to intake valve A(107 by gas conduit), intake valve B(109), intake valve C(111), the air-flow that each intake valve is used for conducting or blocks between cuff and air pump; After intake valve, be connected respectively to corresponding blood pressure cuff A(102 again), blood pressure cuff B(103), blood pressure cuff C(104), blood pressure cuff for bind arm and by arm vascular pressure by conduit to pressure transducer; Another expanding channels air bleeding valve A(108 of blood pressure cuff A (102)) and pressure transducer A(105); Another expanding channels air bleeding valve B(110 of blood pressure cuff B (103)) and pressure transducer B(106), another expanding channels air bleeding valve C(112 of blood pressure cuff C (104)), each air bleeding valve is used for defeated release or keeps cuff pressure, and pressure transducer is used for the air pressure of Measure blood pressure cuff perception.Inflator pump (101), intake valve, air bleeding valve are controlled by cuff air pressure control unit (113).Arm vascular pressure is through pressure transducer A(105) and pressure transducer B(106), the small-signal of output is by signal condition and A/D sample circuit (114) real-time sampling; Sampled result is processed and computing by data processing module (115); The parameter of the real-time display and assessment vascular endothelial function that finally complete sampled data by display module (116) exports.
Before starting blood pressure measurement, by blood pressure cuff A(102) and blood pressure cuff B(103) be bundled in experimenter two arm on hand respectively, for after the pressurizing arm vascular pressure being transferred to pressure transducer, blood pressure cuff C(104) be bundled in the underarm of a wherein arm, for blocker arm blood flow after the pressurizing.
Measure and start, needed the calibration of measuring system between both arms.Calibration process comprises two measuring phases: 1) open air bleeding valve A(108), air bleeding valve B(110), air bleeding valve C(112); Signal condition and A/D sample circuit (114) are according to the frequency sampling 1 minute of 100Hz, and real time record pressure transducer A(105) vector of samples V10, the pressure transducer B(106 of correspondence) the vector of samples V11 of correspondence, calculate afterwards at cuff without the datum drift under pressure condition
; 2) close air bleeding valve A(108), air bleeding valve B(110); Open intake valve A(107), intake valve B(109), and to blood pressure cuff A(102) and blood pressure cuff B(103) inflate and keep separately independently 20mmHg air pressure; Same signal condition and A/D sample circuit (114) are according to the frequency sampling 1 minute of 100Hz, and real time record pressure transducer A(105) vector of samples V20, the pressure transducer B(106 of correspondence) the vector of samples V21 of correspondence, calculate the amplitude multiplying power under cuff actual measurement condition
.
After having calibrated, keep blood pressure cuff A(102) and blood pressure cuff B(103) respective independently 20mmHg air pressure 5 minutes is constant, makes experimenter's state relatively stable.After 5 minutes, to blood pressure cuff C(104) be inflated to 180mmHg, and keep 5 minutes; Blocking blood flow is after 5 minutes, control air bleeding valve C(112) release blood pressure cuff C(104 fast) in air pressure to 0, by signal condition and A/D sample circuit (114) frequency sampling 5 minutes according to 100Hz, and real time record pressure transducer A(105) vector of samples V30, the pressure transducer B(106 of correspondence) the vector of samples V31 of correspondence, calculate the blood pressure cuff A(102 after calibration) and blood pressure cuff B(103) vector of samples is respectively:
and V31.
Measure and terminate, according to the time, segmentation calculating is carried out to the sampled result after calibration, draws blood pressure cuff C(104) the endothelial function evaluate parameter of after the aerofluxus moment 1 minute, 2 minutes and 5 minutes,
,
with
, wherein index number represents the scope of data chosen from sampled result; Parameter is finally exported by display module (116), also recovers spring function in rear different time sections, realize non-invasive measurement and the assessment of vascular endothelial function for assessment of experimenter's upper arm blood vessel at ischemia.
Claims (5)
1. a noninvasive vascular endothelial function apparatus for evaluating, comprise three blood pressure cuffs, cuff air pressure control unit, inflator pump, two pressure transducers, signal condition and A/D Acquisition Circuit, data processing unit and display modules, each blood pressure cuff all has independently with the inlet channel of intake valve and the exhaust passage with air bleeding valve, the inlet channel of each blood pressure cuff is connected with inflator pump, and inflator pump, each intake valve and air bleeding valve are controlled by cuff air pressure control unit; Be respectively equipped with pressure transducer in the exhaust passage of wherein two blood pressure cuffs, two pressure transducer connection signals conditionings and A/D Acquisition Circuit, signal condition and A/D Acquisition Circuit connection data processing unit, data processing unit connects display module.
2. noninvasive vascular endothelial function apparatus for evaluating according to claim 1, is characterized in that, described cuff air pressure control unit controls inflator pump, each intake valve, each exhaust valve operation, keeps and Rapid degassing the quantitative inflation of each blood pressure cuff, air pressure.
3. noninvasive vascular endothelial function apparatus for evaluating according to claim 1, is characterized in that, described signal condition and A/D Acquisition Circuit realize amplification and the filtering that each cuff baroceptor exports small-signal; Realize the analog/digital conversion of signal, and complete real-time sampling.
4. noninvasive vascular endothelial function apparatus for evaluating according to claim 1, is characterized in that, the parameter that the cuff pressure data that described data processing unit obtains sampling carry out pretreatment and assessment vascular endothelial function calculates.
5. noninvasive vascular endothelial function apparatus for evaluating according to claim 1, it is characterized in that, described blood pressure cuff is stiff arms cuff, in three blood pressure cuffs, two blood pressure cuffs for binding left and right two arms, and by arm vascular pressure by conduit to respective pressure transducer; Blocker arm blood flow is inflated when another blood pressure cuff is for measuring.
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Cited By (5)
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| CN107411778A (en) * | 2017-05-17 | 2017-12-01 | 上海交通大学 | A kind of non-invasive detection system of peripheral vessel blood flow regulation function |
| CN111436997A (en) * | 2020-04-21 | 2020-07-24 | 重庆大学附属肿瘤医院 | Self-adaptive safety blocking device for noninvasive detection of vascular endothelial function |
| CN112690769A (en) * | 2020-12-21 | 2021-04-23 | 河南科技大学第一附属医院 | Automatic blood pressure measuring instrument for general surgery department |
| CN113747834A (en) * | 2019-04-25 | 2021-12-03 | 参凯尔株式会社 | Sensor module for measuring blood pressure and wrist-worn portable blood pressure measuring device using same |
| PL442630A1 (en) * | 2022-10-25 | 2024-04-29 | Musz Przemysław Imer Systems | Device for measuring the parameters of the vascural endothelium and a method for processing the measuring signal |
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