CN1052164C - Traditional Chinese medicine preparation for treating senile dementia - Google Patents
Traditional Chinese medicine preparation for treating senile dementia Download PDFInfo
- Publication number
- CN1052164C CN1052164C CN 97117052 CN97117052A CN1052164C CN 1052164 C CN1052164 C CN 1052164C CN 97117052 CN97117052 CN 97117052 CN 97117052 A CN97117052 A CN 97117052A CN 1052164 C CN1052164 C CN 1052164C
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- senile dementia
- radix
- medicine
- chinese medicine
- pharmaceutical composition
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- Expired - Lifetime
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- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 17
- 206010039966 Senile dementia Diseases 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims description 34
- 238000002360 preparation method Methods 0.000 title description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 12
- 235000008434 ginseng Nutrition 0.000 claims abstract description 12
- 241000208340 Araliaceae Species 0.000 claims description 11
- 229940089161 ginsenoside Drugs 0.000 claims description 6
- 229930182494 ginsenoside Natural products 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 210000004556 brain Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 239000000686 essence Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 206010012289 Dementia Diseases 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 2
- 201000004810 Vascular dementia Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- -1 lipid peroxide Chemical class 0.000 description 2
- 230000006386 memory function Effects 0.000 description 2
- 239000002664 nootropic agent Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 2
- 229960002646 scopolamine Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
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- 206010041954 Starvation Diseases 0.000 description 1
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- 230000032683 aging Effects 0.000 description 1
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- 230000002490 cerebral effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001713 cholinergic effect Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a pharmaceutical composition for treating senile dementia, which comprises tuber fleeceflower root, epimedium herb, ginseng, grassleaf sweelflag rhizome, kudzuvine root and Szechuan lovage rhizome.
Description
The present invention is a kind of Chinese medicine preparation for the treatment of senile dementia, and said preparation is to be the medicament that component is prepared from Chinese medicine, belongs to the field of Chinese medicines.
Along with the development of society, the prolongation of people's average life, increasing people suffers from Senile disease, comprises senile dementia.Wherein much more to see, account for the 80%-90% of senile dementia with dementia of the Alzheimer type and vascular dementia.For the treatment of senile dementia, doctor trained in Western medicine mainly adopts cerebral vasodilator, brain metabolism improving medicine and the nootropics can medicine, but curative effect is dissatisfied, because of side effect obviously or cost an arm and a leg, the patient is difficult to adhere to medication.Therefore, seek a kind of Chinese medicine that can effectively treat senile dementia, will help geratologous development and bring benefit to the mankind.
The present invention seeks to develop a kind of Chinese medicine preparation for the treatment of senile dementia.
The traditional Chinese medical science thinks that the cause of disease of senile dementia is that mainly old internal organs are tired out, and painstaking effort gradually consume, deficiency of kidney-essence, so that the mistake of heart kidney is foster, and the brain inanition is difficult to support brain and keeps god; Or deficiency-weakness of spleen-QI, failing of the spleen to transport is given birth in expectorant is turbid, hoodwinks key clearly; Or blood stasis due to qi deficiency, the resistance of venation numbness, brains lose supports.The rule of treatment is when being advisable with the kidney invigorating blood stasis dispelling of having one's ideas straightened out.
According to above-mentioned Therapeutic Principle, medicine of the present invention is selected the Radix Polygoni Multiflori liver and kidney tonifying for use on prescription, nourish blood, and YIN nourishing, arresting seminal emission, Herba Epimedii kidney-replenishing, beneficial vital essence are with Radix Polygoni Multiflori coordination of YIN and YANG.Foster essences such as Radix Polygoni Multiflori benefit by the supporing yang product of Herba Epimedii, are evaporated to agitate essence and blood, on fill in brain and give birth to marrow, i.e. " treating YIN within YANG ", the reason of " gas spermatogenesis ".Two medicines close thinks monarch, plays the effect of filling out the marrow Fructus Alpiniae Oxyphyllae altogether.Radix Ginseng is the QI invigorating key medicine, and the Radix Polygoni Multiflori nourishes cloudy liquid, the liver benefiting that nourishes blood, and mutual reinforcement between is a usefulness, QI invigorating and blood producing is filled out marrow.In addition, Radix Ginseng can also be pacified spirit, and spasmolytic is throbbed with fear, happy Fructus Alpiniae Oxyphyllae.Rhizoma Acori Graminei can expectorant turbid, happy key, the will of allaying excitement, so the mind that all phlegm-damp are hoodwinked due to the key clearly is dazed and confused, epilepsy is stupid to wait disease, whenever uses always more, be eliminate phlegm for resuscitation, the mind tranquilizing and the heart calming good merchantable brand, with the ginseng compatibility, can strengthen the effect that it is eliminated phlegm for resuscitation.Radix Puerariae has to rise sends out sub-merit, the kidney invigorating fill out add on the marrow medicine basis Radix Puerariae can the meridian dredging draw positive clearly, thereby reach the effect that marrow must be supported.The Rhizoma Chuanxiong merit is arrogated to oneself promoting flow of QI and blood, can blood stasis dispelling stagnate, open the gas stasis of blood.The up head, priming is gone into brain.Above-mentioned Six-element medicine so cooperates, and play altogether and tonifies Qi of the kidney, fills out the marrow Fructus Alpiniae Oxyphyllae full side, the merit of the blood stasis dispelling of eliminating the phlegm.
Therefore, the active princlple of medicine of the present invention is based on following pharmaceutical composition.
It is (weight portion) that pharmaceutical composition of the present invention is formed:
Radix Polygoni Multiflori 100-300
Herba Epimedii 80-200
Radix Ginseng 80-200
Rhizoma Acori Graminei 80-200
Radix Puerariae 150-300
Rhizoma Chuanxiong 80-200
The preferred weight ratio of pharmaceutical composition each component of the present invention is as follows:
Radix Polygoni Multiflori 150
Herba Epimedii 100
Radix Ginseng 100
Rhizoma Acori Graminei 100
Radix Puerariae 200
Rhizoma Chuanxiong 100
Radix Ginseng can replace with the ginsenoside in the above-mentioned compositions, and every 80-200 gram Radix Ginseng can restrain the ginsenoside with 1-2 and replace.
Above-mentioned pharmaceutical composition is the taproot that realizes the object of the invention, but, disclose the inventor under the situation of pharmaceutical composition taproot of above-mentioned treatment senile dementia, those skilled in the art can carry out conventional adding to aforementioned pharmaceutical compositions and simplify sanction according to theory of Chinese medical science.The plus-minus of this routine is those skilled in the art's general technical activity.So long as the general technology plus-minus that on pharmaceutical composition taproot of the present invention basis, is carried out; all stay within the scope of protecting of the present invention; for example; can add conventional QI invigorating in the middle of the pharmaceutical composition of the present invention, invigorate blood circulation, reduce phlegm, have one's ideas straightened out, nootropic drug; substitute or strengthen the present invention and have the component of above-mentioned pharmacological action; change as long as this change is a kind of unsubstantiality, still belong within protection scope of the present invention.
Aforementioned pharmaceutical compositions of the present invention according to the preparation process of routine, can be prepared into any pharmaceutical dosage form that is suitable for using clinically.For example, pill, tablet, unguentum, powder, capsule, oral liquid, injection etc.
The preparation method of medicine capsule of the present invention is:
By described pharmaceutical composition weight ratio, Radix Polygoni Multiflori, Herba Epimedii, Rhizoma Acori Graminei, Radix Puerariae, Rhizoma Chuanxiong are decocted with water 2 times, each 0.5-2.5 hour, amount of water can not have powder to be advisable with water, merges 2 times decocting liquid, left standstill 3-5 hour, filtered, and abandoned sediment; The filtrate heating is concentrated lyophilization, pulverize.Weight ratio according to compositions adds the ginsenoside in above-mentioned powder, and mixing incapsulates.
Medicine of the present invention has definite curative effect for senile dementia.
Known senile dementia and age growth are closely related, memory and cognitive decrease with the age ageing, and its biochemical pathologic basis is the degeneration of cholinergic system.In addition, free radical increases the generation that also can promote senile dementia.The medicament of using preparation of pharmaceutical compositions of the present invention carries out animal experiment, found that this drug oral can obviously strengthen the learning and memory function of senile rat (seeing Table 1,2), improve the ability of learning and memory (seeing Table 3) that scopolamine causes dementia mice, open brain, the liver lipid peroxide content (seeing Table 4) that can significantly reduce the D-galactose and cause the senilism mice.Show that pharmaceutical composition of the present invention is a kind of effective treatment senile dementia and old amnemonic active drug.
Table 1 medicine of the present invention is swum out of the influence of time to the senile rat water maze test
Swim out of the time (second) (M ± SD)
N (23 months) 4 98.5 ± 25.0 83.3 ± 37.5 70.8 ± 52.5 54.4 ± 37.3 old age+medicine 3 76.3 ± 35.2 48.0 ± 36.8 33.3 ± 19.5 27.2 ± 5.0 11.1 0.002 in the 1st day the 2nd day the 3rd day the 4th day F value P youth (June) 5 46.3 ± 40.0 37.7 ± 33.1 17.1 ± 4.2 18.4 ± 8.3 38.5 0.000 old age
Variance analysis: young group is organized relatively with old
Old age+medicine group and old the group relatively
Table 2 medicine of the present invention is to the influence of senile rat water maze test errors number
Errors number (second) (M ± SD)
4 4.5 ± 2.3 3.6 ± 2.9 1.8 ± 1.9 1.5 ± 1.5 old age of the 1st day the 2nd day the 3rd day the 4th day F value P youth (June) 5 2.5 ± 2.6 1.8 ± 2.7 0.1 ± 0.3 1.2 ± 1.1 10.3 0.002 old age (23 months) of n+medicine 3 3.2 ± 1.6 2.3 ± 2.9 1.2 ± 1.2 0.7 ± 1.0 3.9 0.055
Variance analysis: young group is organized relatively with old
Old age+medicine group and old the group relatively
Table 3 medicine of the present invention causes the influence of dementia mice memory function and fatigue resistance to scopolamine
Keep away dark test swimming with a load attached to the body test
Old age (23 months) 15 220.1 ± 113.5 0.400 ± 0.507 in n latent time (second) errors number (second) young (June) 14 275.2 ± 70.5 0.200 ± 0.414 70.40 ± 54.69 31.52 ± 9.35 old age+medicine 15 263.1 ± 83.2 0.200 ± 0.414 56.26 ± 34.16
Table 4 medicine of the present invention causes the influence of senilism mouse brain, liver lipid peroxide (MDA) to the D-galactose
MDA (O.D. value)
N brain liver contrasts 12 0.0107 ± 0.0043
* *0.1072 ± 0.0189
* *D-galactose 12 0.7051 ± 0.0444 1.7657 ± 0.1002 half+medicine 12 0.0727 ± 0.0610
* *0.1585 ± 0.0590
* *
Through animal experiment and clinical observation, pharmaceutical preparation of the present invention all has better therapeutic effect to Alzheimer and vascular dementia and incomplete brain blood supply, old dysmnesia.
Embodiment 1
Radix Polygoni Multiflori Preparata 150 grams
Herba Epimedii 100 grams
Ginsenoside's 1.5 grams
Rhizoma Acori Graminei 100 grams
Radix Puerariae 200 grams
Rhizoma Chuanxiong 100 grams
Press recipe quantity, with the Radix Polygoni Multiflori, Herba Epimedii, Rhizoma Acori Graminei, Radix Puerariae, Rhizoma Chuanxiong add 3 times of water gagings and decoct twice, each 1 hour; Merge 2 times decocting liquid, left standstill 4 hours, filter, abandon sediment; The filtrate heating is concentrated lyophilization, pulverization.Press recipe quantity, the ginsenoside is added in the above-mentioned powder, mixing is loaded on capsule, promptly.
Embodiment 2
Radix Polygoni Multiflori Preparata 150 grams
Herba Epimedii 100 grams
Radix Ginseng 100 grams
Rhizoma Acori Graminei 100 grams
Radix Puerariae 200 grams
Rhizoma Chuanxiong 100 grams
Press recipe quantity, with the Radix Polygoni Multiflori, Herba Epimedii, Rhizoma Acori Graminei, Radix Puerariae, Rhizoma Chuanxiong, people participate in 3 times of water gagings and decoct twice, each 1 hour; Merge 2 times decocting liquid, left standstill 4 hours, filter, abandon sediment; The filtrate heating is concentrated, lyophilization, pulverization, mixing is loaded on capsule, promptly.
Claims (3)
1, a kind of pharmaceutical composition for the treatment of senile dementia is characterized in that said composition is to be made by the following raw medicaments in portion by weight thing:
Radix Polygoni Multiflori 100-300
Herba Epimedii 80-200
Radix Ginseng 80-200
Rhizoma Acori Graminei 80-200
Radix Puerariae 150-300
Rhizoma Chuanxiong 80-200
2,, it is characterized in that the weight ratio of composition material medicine is according to the compositions of claim 1:
Radix Polygoni Multiflori 150
Herba Epimedii 100
Radix Ginseng 100
Rhizoma Acori Graminei 100
Radix Puerariae 200
Rhizoma Chuanxiong 100
3, according to the pharmaceutical composition of claim 1 or 2, wherein said Radix Ginseng replaces with the ginsenoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97117052 CN1052164C (en) | 1997-10-13 | 1997-10-13 | Traditional Chinese medicine preparation for treating senile dementia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97117052 CN1052164C (en) | 1997-10-13 | 1997-10-13 | Traditional Chinese medicine preparation for treating senile dementia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1178119A CN1178119A (en) | 1998-04-08 |
| CN1052164C true CN1052164C (en) | 2000-05-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97117052 Expired - Lifetime CN1052164C (en) | 1997-10-13 | 1997-10-13 | Traditional Chinese medicine preparation for treating senile dementia |
Country Status (1)
| Country | Link |
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| CN (1) | CN1052164C (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101243889B (en) * | 2008-03-11 | 2011-05-04 | 湖北中医学院 | Fleece-flower root medicinal food salted duck egg and preparation method thereof |
| CN101269179B (en) * | 2008-04-10 | 2010-09-01 | 贵阳医学院 | Traditional Chinese medicine preparation for treating senile dementia and preparation method thereof |
| CN101317966B (en) * | 2008-07-14 | 2011-06-22 | 孙彩虹 | Medicament for treating senile dementia and preparation method thereof |
| CN101804127B (en) * | 2010-04-28 | 2012-04-18 | 北京大学第一医院 | Compound traditional Chinese medicine extractive composite for preventing and curing Alzheimer disease |
| CN102784257B (en) * | 2010-09-01 | 2015-04-08 | 首都医科大学宣武医院 | Pharmaceutical composition for treating mild cognitive impairment |
| CN101926902A (en) * | 2010-09-01 | 2010-12-29 | 首都医科大学宣武医院 | Pharmaceutical composition for treating mild cognitive impairment |
| CN103055014B (en) * | 2012-12-31 | 2014-09-17 | 青岛华仁技术孵化器有限公司 | Folium ginkgo health product for preventing senile dementia and preparation method thereof |
| CN103479855A (en) * | 2013-09-16 | 2014-01-01 | 青岛中仁药业有限公司 | Preparation method of Chinese materia medica preparation for treating senile dementia |
| CN104383174A (en) * | 2014-12-12 | 2015-03-04 | 天津中医药大学第二附属医院 | Traditional Chinese medicine for treating senile dementia |
| CN113144124A (en) * | 2021-04-16 | 2021-07-23 | 韩旭 | A Chinese medicinal composition for treating Alzheimer type dementia and its decoction |
-
1997
- 1997-10-13 CN CN 97117052 patent/CN1052164C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1178119A (en) | 1998-04-08 |
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