CN105213988A - A kind of Chinese medicine composition being used for the treatment of epilepsy and preparation method thereof - Google Patents
A kind of Chinese medicine composition being used for the treatment of epilepsy and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition being used for the treatment of epilepsy and preparation method thereof, belong to medical art, this Chinese medicine composition is prepared from by following crude drug: Rhizoma Gastrodiae, Rhizoma Cyperi (processed with vinegar), Herba Asari, Rhizoma Corydalis, Concretio Silicea Bambusae, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii, Scolopendra, Lignum Aquilariae Resinatum, fries Semen Sinapis, Rhizoma Curcumae (processed with vinegar), Agkistrodon halys, Lapis Chloriti, Cornu Saigae Tataricae, the Radix Linderae, Radix Saposhnikoviae, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Radix Bupleuri, Rhizoma Arisaematis.Chinese medicine composition provided by the invention, said composition has eliminates the phlegm, and YANG hyperactivity suppressing treats the effects such as epilepsy, and easy to use, instant effect, toxic and side effects is little.The preparation method provided, by carrying out classification process to different material, farthest can utilize the effective ingredient in medicine, and reduce toxic and side effects, meanwhile, medicament ratio of briquetting is high.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition being used for the treatment of epilepsy and preparation method thereof, belong to medical art.
Background technology
Epilepsy (epilepsy), is the electric discharge of cerebral neuron paroxysmal abnormality, causes a kind of chronic disease of of short duration cerebral disorder.According to statistics, about there is the epileptic of about 9,000,000 in China, and about have 400,000 newly-increased patients every year, in China, epilepsy has become the second largest commonly encountered diseases that department of neurology is only second to headache, the complicated clinical manifestation of epilepsy is various, can show as paroxysmal movement, sensation, autonomic nerve, consciousness and mental disorder, the serious Working Life that have impact on patient and the mental status.
In prior art, Western medicine is adopted to carry out Drug therapy, need through the time of about 5 years, and can not drug withdrawal, treatment time is long, and long-term taking Western medicine, injure the organs such as Liver and kidney, undoubtedly the state of an illness is made the matter worse.Therefore, research and development one can fast effectively and lasting medicine, and the Chinese medicine composition of the treatment epilepsy that toxic and side effects is little has very important clinical meaning.
Summary of the invention
For prior art Problems existing, the invention provides a kind of Chinese medicine composition being used for the treatment of epilepsy, said composition has eliminates the phlegm, and YANG hyperactivity suppressing treats the effects such as epilepsy, and easy to use, instant effect, toxic and side effects is little.
Present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of epilepsy, the method, by carrying out classification process to different material, farthest can utilize the effective ingredient in medicine, and reduce toxic and side effects, meanwhile, medicament ratio of briquetting is high.
The technical scheme that the present invention is adopted to achieve these goals is:
The invention provides a kind of Chinese medicine composition being used for the treatment of epilepsy, is be prepared from by the crude drug of following weight: Rhizoma Gastrodiae 68g, Rhizoma Cyperi (processed with vinegar) 68g, Herba Asari 68g, Rhizoma Corydalis 68g, Concretio Silicea Bambusae 116g, Rhizoma Pinelliae 116g, Rhizoma Et Radix Notopterygii 68g, Scolopendra 42g, Lignum Aquilariae Resinatum 42g, fry Semen Sinapis 42g, Rhizoma Curcumae (processed with vinegar) 68g, Agkistrodon halys 68g, Lapis Chloriti 168g, Cornu Saigae Tataricae 22g, Radix Linderae 42g, Radix Saposhnikoviae 42g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 116g, Radix Bupleuri 68g, Rhizoma Arisaematis 116g;
Described crude drug is dry weight;
The dosage form of described Chinese medicine composition is pill.
Present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of epilepsy, comprise the following steps:
(1) by Scolopendra, Agkistrodon halys grinds to form mixed powder, then adds yellow wine, and triethanolamine soaks 25-30min after stirring, and then adds citric acid, and jolting extracts 3 times, merging filtrate after sucking filtration;
(2) by Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis adds medical stone powder and carries out parch 15-20min, then sprays vinegar, utilizes waste heat to continue stewing 8-10min, screens out medical stone powder, dried in the air by raw material cool;
(3) by the same surplus stock of step (2) raw material, (described surplus stock is Rhizoma Gastrodiae, Rhizoma Cyperi (processed with vinegar), Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, fries Semen Sinapis, Rhizoma Curcumae (processed with vinegar), Lapis Chloriti, Cornu Saigae Tataricae, the Radix Linderae, Radix Saposhnikoviae, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens), Radix Bupleuri) grind to form 160 order fine powders, then add above-mentioned filtrate, be prepared into pill.
Further, in step (1), described mixed powder is 1g:8-10mL with the solid-liquid ratio of yellow wine.
Further, the alcohol content of above-mentioned yellow wine is 16-20%.
Further, in step (1), the addition of described triethanolamine accounts for mixed powder gross weight 0.1-0.3%.
Further, in step (1), the addition of described citric acid accounts for the 0.5-0.8% of mixed powder gross weight.
Further, in step (1), the condition that described jolting is extracted is: temperature is 30-35 DEG C, extracts 1.5h at every turn.
Further, in step (2), the addition of described medical stone powder is Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis gross weight 3 times; Described vinegar fountain height accounts for Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, and the 0.5-0.8 of Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis gross weight doubly.
Usage and dosage: pill (watered pill be prepared into, after adding filtrate, can temper to soft or hard and be suitable for, the toughness held, unclamps, and slightly disperses) the heavy 1g of every 10 balls prepared by the present invention, an oral 3g, three times on the one.
The each medical material of the present invention by the compatibility of science, reinforcement and elimination in combination, each medical material synergism, enhancing human body immunity function, thus reach eliminate the phlegm, YANG hyperactivity suppressing treats effect of epilepsy.The present invention, according to different raw materials, carries out different processing methods to it, can improve the utilization rate of medical material, meanwhile, reduces the toxic component in raw material, reduces toxic and side effects.The present invention is in extracts active ingredients process, add triethanolamine in right amount, the stripping of Lac in raw material can be improved, meanwhile, increase the surface activity of each raw material, coordinate the yellow wine of certain alcohol content, improve the dissolution rate of effective ingredient, the abundant stripping of Lac simultaneously, with the glucide synergism in yellow wine, thus improves ratio of briquetting and the resting period of pill; Citric acid add can in and the fishy smell such as methanthiol in medicine, reduce the fishy smell of medicine, improve palatability.Maifanitum can adsorb toxic component and the harmful heavy metal elements such as the ethers volatilized in parch process, reduces material toxicity.
Advantage of the present invention is:
(1) each raw material scientific compatibility, reinforcement and elimination in combination, has and eliminates the phlegm, and YANG hyperactivity suppressing treats effect of epilepsy, easy to use, instant effect, and little to the intestines and stomach burden, toxic and side effects is little, reaches the object of radical cure epilepsy.
(2) by diverse ways process raw material, effective rate of utilization is high, and reduces the toxic and side effects of raw material.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
Be used for the treatment of a Chinese medicine pill for epilepsy, raw material is: Rhizoma Gastrodiae 68g, Rhizoma Cyperi (processed with vinegar) 68g, Herba Asari 68g, Rhizoma Corydalis 68g, Concretio Silicea Bambusae 116g, Rhizoma Pinelliae 116g, Rhizoma Et Radix Notopterygii 68g, Scolopendra 42g, Lignum Aquilariae Resinatum 42g, fry Semen Sinapis 42g, Rhizoma Curcumae (processed with vinegar) 68g, Agkistrodon halys 68g, Lapis Chloriti 168g, Cornu Saigae Tataricae 22g, Radix Linderae 42g, Radix Saposhnikoviae 42g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 116g, Radix Bupleuri 68g, Rhizoma Arisaematis 116g.
The preparation method of above-mentioned Chinese medicine pill, comprises the following steps:
(1) by Scolopendra, Agkistrodon halys grinds to form mixed powder, then yellow wine (alcohol content is 16%) is added according to solid-liquid ratio 1g:10mL, add the triethanolamine accounting for mixed powder gross weight 0.1%, soak 30min after stirring, then add the citric acid accounting for mixed powder gross weight 0.5%, at temperature 35 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis, add the medical stone powder accounting for its gross weight 3 times and carry out parch 15min, then sprays the vinegar accounting for gross weight 0.5 times, utilizes waste heat to continue stewing 8min, screen out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, be prepared into pill; The heavy 1g of every 10 balls.
Embodiment 2
Be used for the treatment of a Chinese medicine pill for epilepsy, raw material composition is with embodiment 1.
Preparation method comprises the following steps:
(1) by Scolopendra, Agkistrodon halys grinds to form mixed powder, then yellow wine (alcohol content is 20%) is added according to solid-liquid ratio 1g:8mL, add the triethanolamine accounting for mixed powder gross weight 0.3%, soak 25min after stirring, then add the citric acid accounting for mixed powder gross weight 0.6%, at temperature 30 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis, add the medical stone powder accounting for its gross weight 3 times and carry out parch 15min, then sprays the vinegar accounting for gross weight 0.7 times, utilizes waste heat to continue stewing 9min, screen out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, be prepared into pill; The heavy 1g of every 10 balls.
Embodiment 3
Be used for the treatment of a Chinese medicine pill for epilepsy, raw material composition is with embodiment 1.
Preparation method comprises the following steps:
(1) by Scolopendra, Agkistrodon halys grinds to form mixed powder, then yellow wine (alcohol content is 18%) is added according to solid-liquid ratio 1g:9mL, add the triethanolamine accounting for mixed powder gross weight 0.2%, soak 28min after stirring, then add the citric acid accounting for mixed powder gross weight 0.8%, at temperature 33 DEG C, jolting extracts 3 times, each 1.5h, merging filtrate after sucking filtration;
(2) by Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis, add the medical stone powder accounting for its gross weight 3 times and carry out parch 15min, then sprays the vinegar accounting for gross weight 0.8 times, utilizes waste heat to continue stewing 10min, screen out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, be prepared into pill; The heavy 1g of every 10 balls.
Comparative example 1
Be used for the treatment of a Chinese medicine pill for epilepsy, raw material composition is with embodiment 1.
Preparation method: be ground to 160 order powder after directly being mixed by each raw material, then make the watered pill, the heavy 1g of every 10 balls.
Effect test
1. toxicity test:
Test method: get SD rat 40, body weight 180 ~ 220g, male and female half and half, rat is equally divided into 4 groups, the crude drug that feeding embodiment of the present invention 1-3 and comparative example 1 provide respectively combines.Medicine feeding method is: by pill pulverize prepared by the present invention, be made into suspension with water.Often organize rat three gavage drug suspensions every day, every day, rat dosage was 1.5g/Kg, and Rat Fast can't help water, like this continuous gavage of method 15 days.
Result: during rat medication, the rat of embodiment 1-3, all without poisoning, the phenomena of mortality, is respectively organized activities in rats, appetite is normal.Have no significant change through dissection kidney, liver, adrenal cortex, genitals; After the pill perfusion that comparative example 1 is prepared by simple pill method, 4 rats occur irritated, blood pressure increasing state, lethargy.
Conclusion: as can be seen from the above results, zoopery medication amount used exceeds the dose of adult's clinical application far away, but rat occurs without dead or organ variation situation, therefore can show that medicine of the present invention has no side effect when human body uses.
2. the test of pesticide effectiveness
Test method: SD rat, body weight 250-300g, 40, male and female half and half; Puncture injection epileptic model kindled by kainic acid microinjected into nucleus amygdalae in rats, focus: two forelimb clonic spasm, rearings drop to, the pill of the pill utilizing embodiment 1 to prepare after modeling respectively, comparative example 1 preparation, and phenytoin group, blank group is set, 3 administrations every day, administration 4d and 7d carries out neural behavior scoring, mark is higher, and show that animal behavior obstacle is more serious, concrete evaluation result is in table 1.
Table 1
Compared with blank group,
*p < 0.05,
*p < 0.01.
3. clinical laboratory data
Select hospital outpatient to be diagnosed as epilepsy and lose disease patient 85 example, wherein male 53 example, women 32 example, the age is 6-59 one full year of life, and take medicine pill provided by the invention, adult population takes once 3g, every day twice; 10-18 year patient 1.5g, every day twice; Less than 10 years old patient 1g, every day twice; Within 35 days, be a course for the treatment of, take 4-5 the course for the treatment of.
Tcm syndrome:
Recovery from illness: clinical symptom disappearance, limb function obviously improves, and life can take care of oneself;
Effective: cardinal symptom alleviates, limb function improves;
Invalid: clinical symptoms is without significant change.
Concrete clinical laboratory data the results are shown in Table 2.
Table 2
4. model case
Model case 1: Liu, man, be headache epilepsy through hospital diagnosis, every day shows effect 2-3 time, each more than 10 minutes, through Chinese and western medicine diagnosis and treatment 1 year how much effect, take pill 25 days prepared by the embodiment of the present invention 1, outbreak stops, consolidate 1 course for the treatment of, before and after patient medication, blood, urine, liver function, kidney function test are all normal, have no adverse reaction, follow up a case by regular visits to and have no recurrence in three months.
Model case 2: Ma, female, 14 years old, changed meningitis when 7 years old, more after, right arm is often numb, often twitches without timing, suddenly faints during outbreak, the eyes turning upwards, head is to layback, and locked mouth is grited one's teeth, sialorrhea, shouts strangely, tic of the limbs, after outbreak, expression is gradually waken up, then lethargy, and the pill 25 days back legs taking the embodiment of the present invention 2 preparation are not taken out, remaining disease comparatively alleviates before medication, takes primary symptom after 2 months and obviously alleviates or disappear, take all disease disappearances after 3 months, diet increases, of pink and healthy-looking, healthy.
Model case 3: gold certain, man, 6 years old, the high hot convulsion of 5 years old half, through curing.Suddenly faint after month remaining, syncope, gnathospasma, slobbering, the eyes turning upwards, revives after last for several minutes, is then sunk into sleep, as usual after waking up, recurrent exerbation, take this medicine after 12 days attack times obviously reduce, after 45 days, all diseases disappear, and follow up a case by regular visits to and have no recurrence in 4 years.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not by the restriction of embodiment; other is any do not deviate from spirit of the present invention and principle under make change, modification, combination, substitute, simplify and all should be equivalent substitute mode, be included within protection scope of the present invention.
Claims (8)
1. being used for the treatment of a Chinese medicine composition for epilepsy, it is characterized in that, is be prepared from by the crude drug of following weight: Rhizoma Gastrodiae 68g, Rhizoma Cyperi (processed with vinegar) 68g, Herba Asari 68g, Rhizoma Corydalis 68g, Concretio Silicea Bambusae 116g, Rhizoma Pinelliae 116g, Rhizoma Et Radix Notopterygii 68g, Scolopendra 42g, Lignum Aquilariae Resinatum 42g, fry Semen Sinapis 42g, Rhizoma Curcumae (processed with vinegar) 68g, Agkistrodon halys 68g, Lapis Chloriti 168g, Cornu Saigae Tataricae 22g, Radix Linderae 42g, Radix Saposhnikoviae 42g, Sichuan Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 116g, Radix Bupleuri 68g, Rhizoma Arisaematis 116g;
Described crude drug is dry weight;
The dosage form of described Chinese medicine composition is pill.
2. a preparation method for Chinese medicine composition as claimed in claim 1, is characterized in that, comprises the following steps:
(1) by Scolopendra, Agkistrodon halys grinds to form mixed powder, then adds yellow wine, and triethanolamine soaks 25-30min after stirring, and then adds citric acid, and jolting extracts 3 times, merging filtrate after sucking filtration;
(2) by Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii, Rhizoma Arisaematis adds medical stone powder and carries out parch 15-20min, then sprays vinegar, utilizes waste heat to continue stewing 8-10min, screens out medical stone powder, dried in the air by raw material cool;
(3) step (2) raw material is ground to form 160 order fine powders with surplus stock, then add above-mentioned filtrate, be prepared into pill.
3. preparation method according to claim 2, is characterized in that: described mixed powder is 1g:8-10mL with the solid-liquid ratio of yellow wine.
4. preparation method according to claim 3, is characterized in that: the alcohol content of described yellow wine is 16-20%.
5. preparation method according to claim 2, is characterized in that, the addition of described triethanolamine accounts for mixed powder gross weight 0.1-0.3%.
6. preparation method according to claim 2, is characterized in that: the addition of described citric acid accounts for the 0.5-0.8% of mixed powder gross weight.
7. preparation method according to claim 2, is characterized in that, the condition that described jolting is extracted is: temperature is 30-35 DEG C, extracts 1.5h at every turn.
8. preparation method according to claim 2, is characterized in that: the addition of described medical stone powder is Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis gross weight 3 times; Described vinegar fountain height accounts for Herba Asari, Rhizoma Corydalis, Rhizoma Pinelliae, and the 0.5-0.8 of Rhizoma Et Radix Notopterygii and Rhizoma Arisaematis gross weight doubly.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068656A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for traditional Chinese medicinal preparation epilepsy pills |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068656A (en) * | 2009-11-19 | 2011-05-25 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Quality control method for traditional Chinese medicinal preparation epilepsy pills |
Non-Patent Citations (2)
| Title |
|---|
| 左言富等主编: "《简明中成药辞典》", 31 October 2002 * |
| 贺建国: "中西医结合治疗难治性癫痫68例", 《光明中医》 * |
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Application publication date: 20160106 |