CN105213901A - A kind of antigout drug compositions, its application and preparation method - Google Patents
A kind of antigout drug compositions, its application and preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of antigout drug compositions, its application and preparation method, the raw material that described antigout drug compositions mainly comprises following weight portion is made: Radix Aconiti 30-60 part, Radix Aconiti Kusnezoffii 30-60 part, Radix Aconiti Lateralis Preparata 30-150 part, Herba Asari 10-30 part, Rhizoma Smilacis Glabrae 40-120 part, Rhizoma Dioscoreae Septemlobae 40-150 part, Scorpio 10-70 part, Scolopendra 4-10 part, Radix Et Rhizoma Rhei 30-60 part, Semen Strychni 0.4-0.9 part, Semen Sinapis Albae 20-40 part, Squama Manis 5-20 part, Herba Epimedii 30-120 part, Fructus Psoraleae 20-120 part, Semen Cuscutae 30-120 part, Semen Astragali Complanati 30-120 part.In the compositions of antigout drug disclosed in the present invention, various raw material matches, and plays invigorating YANG kidney and spleen invigorating dampness removing, helps the effect with dispersing swelling and dissipating binds, thus play the effect of gout, determined curative effect and significantly.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of antigout drug compositions, its application and preparation method.
Background technology
Gout is also known as " hyperuricemia ", and disorders of purine metabolism, belongs to arthritis one.Gout is that the metabolism of the material of purine in human body gets muddled, and the synthesis of uric acid increases or discharges and reduces, and causes hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and kidney with the form of sodium salt, causes and organizes foreign body inflammatory reaction, be i.e. gout.
Doctor trained in Western medicine commonly uses releasing uric acid, colchicine, salicylic acid are received, the medicine such as meticorten, dexamethasone, invigorate blood circulation to remove wind, pain relieving is auxiliary, period in a medicine is effective, after drug withdrawal, the state of an illness recurs again, and period in a medicine occurs with the symptom of Liver and kidney pain, and have frequent micturition, urgent micturition, the side effect such as nervous, the state of an illness is not fundamentally cured and is alleviated.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of antigout drug compositions, its application and preparation method.Inventor thinks, that YIN-cold water is wet, interior by delicious food is excessive usually outside the cause of disease of gout, wet heap soil or fertilizer over and around the roots is tied for a long time in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, cold-damp and forms this disease, therefore various raw material matches in the compositions of antigout drug disclosed in the present invention, play invigorating YANG kidney and spleen invigorating dampness removing, assistant, with the effect of dispersing swelling and dissipating binds, thus plays the effect of gout, determined curative effect and significantly.
The technical solution adopted in the present invention is:
A kind of antigout drug compositions, the raw material mainly comprising following weight portion is made: Radix Aconiti 30-60 part, Radix Aconiti Kusnezoffii 30-60 part, Radix Aconiti Lateralis Preparata 30-150 part, Herba Asari 10-30 part, Rhizoma Smilacis Glabrae 40-120 part, Rhizoma Dioscoreae Septemlobae 40-150 part, Scorpio 10-70 part, Scolopendra 4-10 part, Radix Et Rhizoma Rhei 30-60 part, Semen Strychni 0.4-0.9 part, Semen Sinapis Albae 20-40 part, Squama Manis 5-20 part, Herba Epimedii 30-120 part, Fructus Psoraleae 20-120 part, Semen Cuscutae 30-120 part, Semen Astragali Complanati 30-120 part.
Certainly, in order to reach better drug effect, preferred raw material and proportioning are, a kind of antigout drug compositions, the raw material mainly comprising following weight portion is made: Radix Aconiti 40-50 part, Radix Aconiti Kusnezoffii 40-50 part, Radix Aconiti Lateralis Preparata 60-120 part, Herba Asari 15-25 part, Rhizoma Smilacis Glabrae 60-100 part, Rhizoma Dioscoreae Septemlobae 70-120 part, Scorpio 20-60 part, Scolopendra 6-8 part, Radix Et Rhizoma Rhei 40-50 part, Semen Strychni 0.5-0.8 part, Semen Sinapis Albae 25-35 part, Squama Manis 10-15 part, Herba Epimedii 60-90 part, Fructus Psoraleae 50-90 part, Semen Cuscutae 50-100 part, Semen Astragali Complanati 50-100 part.
As above-mentioned preferred raw material and proportioning, a kind of antigout drug compositions, the raw material mainly comprising following weight portion is made: Radix Aconiti 45 parts, Radix Aconiti Kusnezoffii 45 parts, Radix Aconiti Lateralis Preparata 90 parts, Herba Asari 20 parts, Rhizoma Smilacis Glabrae 80 parts, Rhizoma Dioscoreae Septemlobae 95 parts, Scorpio 40 parts, Scolopendra 7 parts, Radix Et Rhizoma Rhei 45 parts, Semen Strychni 0.65 part, Semen Sinapis Albae 30 parts, Squama Manis 12 parts, Herba Epimedii 75 parts, Fructus Psoraleae 70 parts, Semen Cuscutae 75 parts, Semen Astragali Complanati 75 parts.
During a kind of antigout drug compositions of inventor in long-term enforcement the present invention, find that Radix Aconiti on the market, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis Preparata are concocted lack of standardization, in order to ensure the drug safety of patient, guarantee curative effect simultaneously, preferred technical scheme is, described Radix Aconiti is Radix Aconiti, described Radix Aconiti Kusnezoffii is Radix Aconiti Kusnezoffii, described Radix Aconiti Lateralis Preparata is Radix Aconiti Lateralis.That is, use in the present invention do not concoct Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis Preparata as raw material, do in following process and concoct process, certainly, also can directly use adopt concocting method process of the present invention Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis Preparata.
The invention also discloses described antigout drug compositions and preparing the application in anti-gout drugs, certainly, described medicine is medically acceptable any preparation.
Conveniently patient uses and ensures curative effect, and preferred technical scheme is, the dosage form of described medicine is decoction, pill or capsule.
Below, respectively the preparation method of decoction, pill or capsule is described.
Prepare a method for described decoction, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting;
B, by the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata and other raw materials with decocting, get its decoction liquor, be decoction.
In order to further facilitate the extraction to effective ingredient in raw material, the technical scheme of refinement is,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
In step b, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are added surplus stock, and add Rhizoma Zingiberis Recens 15-25 part and Fructus Jujubae 15-20 part, the pure water adding 1500-2500 part again soaks after 1-2 hour, carry out decoction operation again, after getting its decoction liquor, the pure water adding 1500-2500 part again in residue medicinal residues carries out decoction operation and gets its decoction liquor, and the decoction liquor obtained twice mixes and obtains decoction.
Prepare a method for described pill, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, the mixture of fecula and water will be added in medicated powder, pill after stirring.
It should be noted that, fecula is starch, is a kind of adjuvant conventional in the formulation.
In order to further facilitate the extraction to effective ingredient in raw material, the technical scheme of refinement is,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
Step c Chinese medicine powder: water: the ratio of fecula is 10:7:2; First by water and fecula mix homogeneously, heating in after gelatin, then joins in medicated powder; After medicated powder and mixture stir, use machine for making water-bindered pills pill, the quality of ball is 0.1-0.3g.
Prepare a method for described capsule, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, medicated powder to be incapsulated, obtain capsule.
In order to further facilitate the extraction to effective ingredient in raw material, the technical scheme of refinement is,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
In step c, the model of capsule is No. 1 No. 2 or No. 3.
It should be noted that, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis dry by the step a in said method after decocting again, be the concocting process of described Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis Preparata, object be in order to avoid use circulate on the market because of concoct lack of standardization and cause gallbladder Ba Shui to exceed standard Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis Preparata.
For the ease of understanding the present invention, below the raw material in the present invention and drug effect are further elaborated.
Radix Aconiti, Classification system Aconitumcarmichaelii/RadixAconiti, Angiospermae, Ranunculaceae, Aconitum, late June excavated to early August, and removing daughter root, fibrous root and silt, dry and get final product.Radix Aconiti is pungent, bitter, heat; Very toxic; GUIXIN, liver,kidney,spleen warp.Radix Aconiti has expelling wind and removing dampness, effect of antalgic, has a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.
Radix Aconiti Kusnezoffii, is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb AconitumkusnezoffiiReichb., excavates when autumn, stem and leaf was withered, and removing fibrous root and silt, be drying to obtain, Radix Aconiti Kusnezoffii acrid in the mouth, hardship, hot in nature; GUIXIN, liver,kidney,spleen warp.Radix Aconiti Kusnezoffii has expelling wind and removing dampness, effect of antalgic, and for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain and narcotic analgesic.
Radix Aconiti Lateralis Preparata, formal name used at school RADIXACONITILATERALISPREPARATA.Cross section taupe, be full of little space and the polygon cambium layer ring grain of salt efflorescence as seen, ring grain inner conduit bundle is misaligned; Feeble QI, salty in the mouth and numb, perverse tongue.Radix Aconiti Lateralis Preparata is pungent, sweet, hot greatly; Poisonous; GUIXIN, kidney, spleen channel.Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by effect of wind-cold damp pathogen.
Herba Asari is the dry root welding technology of aristolochiaceae plant Herba Asari, Seoul Herba Asari or magnificent Herba Asari.Herba Asari is pungent, temperature; GUIXIN, lung, kidney channel.Herba Asari has the cold expelling that induces sweat, wind-expelling pain-stopping, sensible, effect of warming the lung to resolve fluid-retention.
Rhizoma Smilacis Glabrae, be the dry rhizome of liliaceous plant smilacis glabra, Chang Yuxia, Qiu Erji excavate, removing fibrous root, and after cleaning, drying is used as medicine; Or drying is used as medicine after taking advantage of fresh-cut flakiness.Rhizoma Smilacis Glabrae sweet in the mouth, light, property is put down.Rhizoma Smilacis Glabrae has removing toxic substances, and dehumidifying, effect of easing joint movement, is mainly used in the limbs contracture caused by syphilis and mercurialism, bones and muscles pain.
Rhizoma Dioscoreae Septemlobae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Septemlobae DioscoreaseptemlobaThunbt and Dioscoreaceae Plant Powder back of the body Rhizoma Dioscoreae DioscoreahypoglaucaPalibin.Autumn, season in winter two excavate, and removing fibrous root, cleans, and section, dries and get final product.Rhizoma Dioscoreae Septemlobae is bitter, flat; Return kidney, stomach warp.Rhizoma Dioscoreae Septemlobae has dampness removing and goes turbid, effect of wind expelling stagnation removing, for stranguria marked by chyluria, and nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.
Scorpio is the dry body of Buthidae animal Scorpio ButhusmartensiiKarsch.Catch at the beginning of spring Mo to autumn, removing silt, puts boiling water or boils in saline, boil to catalepsy, pull out, put ventilation, dry in the shade and get final product.Scorpio is pungent, flat; Return Liver Channel.Scorpio has endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, effect of dispersing pathogen accumulation, and for liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port
hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Scolopendra is the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH ScolopendrasubspinipesmutilansL.Koch.Spring, Xia Erji catch, and insert end to end with bamboo chip, exceptionally straight, are drying to obtain.Scolopendra is pungent, temperature; Return Liver Channel.Scolopendra has endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, effect of dispersing pathogen accumulation, and for liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port
hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula, snake bite and insect sting.
Radix Et Rhizoma Rhei, for the dry root and rhizome of polygonum rheum palmatum RheumpalmatumL., Rheum tanguticum RheumtanguticumMaxim.exBalf. or Rheum officinale RheumofficinaleBaill., autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing, removing radicula, scrape off crust, valve cutting or section, rope is worn bunchiness drying or convection drying and be get final product.Radix Et Rhizoma Rhei bitter in the mouth, cold in nature, nontoxic; Return spleen, stomach, large intestine, liver, pericardium channel.Radix Et Rhizoma Rhei has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, effect of eliminating blood stasis and inducing menstruation, and for excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed.
Semen Strychni is the dry mature seed of loganiaceae plant Semen Strychni Strychnosnur-vomicaL., mature fruit of gathering winter, takes out seed, dries and get final product.Semen Strychni is bitter, warm; Return liver, spleen channel.Semen Strychni has removing obstruction in the collateral to relieve pain, effect of mass dissipating and swelling eliminating, and for traumatic injury, fracture swells and ache, rheumatoid arthritis stubborn, paralysis and numbness, skin sore, laryngopharynx swelling and pain.
Semen Sinapis Albae, another name hot food, the dry mature seed of Latin literary fame Semensinapis. 1 year or biennial plant Caulis et Folium Sinapis albee SinapisalbaL..Semen Sinapis Albae odorless, acrid in the mouth, peppery; Enter meridian of Hand-TAI YIN, Semen Sinapis Albae has warming the lung eliminating phlegm promoting the circulation of QI, effect of resolving mass and removing the obstruction of the collateral pain relieving, as reducing phlegm by drink, mass dissipating and swelling eliminating.
Squama Manis is the scute of Manidae animal Squama Manis ManispentadactylaLinnaeus, collects scute, cleans, dries and get final product.Squama Manis salty in the mouth, cold nature; Return liver, stomach warp.Squama Manis has eliminating mass of invigorating blood circulation, stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, effect of expel wind to dredge collateral, for Jing Bi WEIJIA, and galactostasis, carbuncle sore tumefacting virus, rheumatic arthralgia, paralysis due to windstroke, numbness contracture.
Herba Epimedii, has another name called Herba Epimedii, Classification system EpimediumLinn.Herba Epimedii nature and flavor are pungent, sweet, temperature, there is kidney invigorating and YANG supporting, bone and muscle strengthening, invigorate vital energy and reinforce the heart, effect of expelling wind and removing dampness, be applicable to the soft disease such as unable for the treatment of sexual impotence, seminal emission, premature ejaculation, sexual disorder, menoxenia, climacteric syndrome, hypertension, rheumatalgia, hemiplegia, numb limbs and tense tendons, knee joint.
Fructus Psoraleae, Classification system: PsoraleacorylifoliaLinn, seed is used as medicine, and Fructus Psoraleae is bitter, pungent, warm; Return kidney, spleen channel.There is effect of kidney invigorating and YANG supporting, spleen reinforcing stomach invigorating, and can the dermatosiss such as psoriasis be controlled.
Semen Cuscutae is the dry mature seed of convolvulaceous plant Cuscuta australis CuscutaaustralisR.Br. or Semen Cuscutae CuscutachinensisLam..Semen Cuscutae has liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, effect of antidiarrheal, and external has effect of pathogenic wind expelling speckle dispelling.Be usually used in deficiency of the liver and kindey, soreness of the waist and knees, impotence and seminal emission, enuresis frequent micturition, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, blurred vision tinnitus, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Flat stem Radix Astragali, Classification system: Astragaluscomplanatus is the plant of pulse family Astragalus, and seed is used as medicine title Semen Astragali Complanati.Semen Astragali Complanati has effect of tonifying the kidney to consolidate the essence, liver heat removing and eyesight improving, cures mainly soreness of waist and knee joint, seminal emission premature ejaculation, the enuresis, frequent micturition, leucorrhea, neurasthenia and the disease such as visual deterioration, diabetes.
Antigout drug compositions of the present invention, has following compatibility relationship: Radix Aconiti Lateralis Preparata, Semen Cuscutae, Semen Astragali Complanati, Herba Epimedii, Fructus Psoraleae with the kidney invigorating the yang aspect of yang, essence (because of the kidney usually involved in chronic disease, its kidney must be empty) in kidney tonifying; Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Radix Et Rhizoma Rhei can removing dampness toxin expellings, cleanse the intestines and stomach long-pending (Xie Quze Zhengan County); Herba Asari, Scorpio, Scolopendra, Squama Manis, Semen Sinapis Albae are with removing obstruction in the collateral to relieve pain, hard masses softening and resolving (because with the passing of time gout can form gout calculus); Semen Strychni (processed), Radix Aconiti, Radix Aconiti Kusnezoffii alleviating pain and detumescence are held concurrently with spleen invigorating.All medicines match and play effect of invigorating YANG the kidney invigorating and essence nourishing, removing damp and turbid, hard masses softening and resolving, removing obstruction in the collateral to relieve pain.
In addition, Rhizoma Zingiberis Recens and Fructus Jujubae also can the kidney invigorating thes yang aspect of yang, and the essence in kidney tonifying, adds in the preparation and can increase curative effect further.
Beneficial effect of the present invention is:
The all medicines of antigout drug compositions of the present invention match and play effect of invigorating YANG the kidney invigorating and essence nourishing, removing damp and turbid, hard masses softening and resolving, removing obstruction in the collateral to relieve pain.
Anti-gout drugs preparation method of the present invention, has step simple to operation, and material effective component loses little advantage.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1
A kind of antigout drug compositions, the raw material comprising following quality is made: Radix Aconiti 30g, Radix Aconiti Kusnezoffii 60g, Radix Aconiti Lateralis Preparata 30g, Herba Asari 30g, Rhizoma Smilacis Glabrae 40g, Rhizoma Dioscoreae Septemlobae 150g, Scorpio 10g, Scolopendra 10g, Radix Et Rhizoma Rhei 30g, Semen Strychni 0.9g, Semen Sinapis Albae 20g, Squama Manis 20g, Herba Epimedii 30g, Fructus Psoraleae 120g, Semen Cuscutae 30g, Semen Astragali Complanati 120g.
Prepare a method for anti-gout drugs decoction based on above-mentioned formula, comprise the following steps:
A, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water are decocted 1 hour after dry again, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are added surplus stock, and add Rhizoma Zingiberis Recens 20g and Fructus Jujubae 15g, after the pure water adding 2500g again soaks 1 hour, carry out decoction operation again, after getting its decoction liquor, the pure water adding 2500g again in residue medicinal residues carries out decoction operation and gets its decoction liquor, and the decoction liquor obtained twice mixes and obtains decoction.
The using method of described decoction is: take night and morning.
Embodiment 2
A kind of antigout drug compositions, the raw material comprising following quality is made: Radix Aconiti 60g, Radix Aconiti Kusnezoffii 30g, Radix Aconiti Lateralis Preparata 150g, Herba Asari 10g, Rhizoma Smilacis Glabrae 120g, Rhizoma Dioscoreae Septemlobae 40g, Scorpio 70g, Scolopendra 40g, Radix Et Rhizoma Rhei 60g, Semen Strychni 0.4g, Semen Sinapis Albae 40g, Squama Manis 5g, Herba Epimedii 120g, Fructus Psoraleae 20g, Semen Cuscutae 120g, Semen Astragali Complanati 30g.
Prepare a method for anti-gout drugs decoction based on above-mentioned formula, comprise the following steps:
A, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water are decocted 3 hours after dry again, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are added surplus stock, and add Rhizoma Zingiberis Recens 15g and Fructus Jujubae 20g, after the pure water adding 1500g again soaks 1.5 hours, carry out decoction operation again, after getting its decoction liquor, the pure water adding 1500g again in residue medicinal residues carries out decoction operation and gets its decoction liquor, and the decoction liquor obtained twice mixes and obtains decoction.
The using method of described decoction is: take night and morning.
Embodiment 3
A kind of antigout drug compositions, the raw material comprising following quality is made: Radix Aconiti 45g, Radix Aconiti Kusnezoffii 45g, Radix Aconiti Lateralis Preparata 90g, Herba Asari 20g, Rhizoma Smilacis Glabrae 80g, Rhizoma Dioscoreae Septemlobae 95g, Scorpio 40g, Scolopendra 7g, Radix Et Rhizoma Rhei 45g, Semen Strychni 0.65g, Semen Sinapis Albae 30g, Squama Manis 12g, Herba Epimedii 75g, Fructus Psoraleae 70g, Semen Cuscutae 75g, Semen Astragali Complanati 75g.
Prepare a method for anti-gout drugs decoction based on above-mentioned formula, comprise the following steps:
A, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water are decocted 2 hours after dry again, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are added surplus stock, and add Rhizoma Zingiberis Recens 25g and Fructus Jujubae 17g, after the pure water adding 2000g again soaks 2 hours, carry out decoction operation again, after getting its decoction liquor, the pure water adding 2000g again in residue medicinal residues carries out decoction operation and gets its decoction liquor, and the decoction liquor obtained twice mixes and obtains decoction.
The using method of described decoction is: take night and morning, and taking continuously one month is a course for the treatment of.
Embodiment 4
A kind of antigout drug compositions, the raw material comprising following quality is made: Radix Aconiti 40g, Radix Aconiti Kusnezoffii 50g, Radix Aconiti Lateralis Preparata 60g, Herba Asari 25g, Rhizoma Smilacis Glabrae 60g, Rhizoma Dioscoreae Septemlobae 120g, Scorpio 20g, Scolopendra 8g, Radix Et Rhizoma Rhei 40g, Semen Strychni 0.8g, Semen Sinapis Albae 25g, Squama Manis 25g, Herba Epimedii 60g, Fructus Psoraleae 90g, Semen Cuscutae 50g, Semen Astragali Complanati 100g.
Be prepared as a method for anti-gout drugs pill based on above-mentioned formula, comprise the following steps:
A, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water are decocted 2 hours after dry again;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, the mixture of fecula and water will be added in medicated powder, medicated powder: water: the ratio of fecula is 10:7:2; First by water and fecula mix homogeneously, heating in after gelatin, then joins in medicated powder; After medicated powder and mixture stir, use machine for making water-bindered pills pill, the quality alternative of ball is made for 0.1,0.2 or 0.3g.
The using method of described pill is: sooner or later respectively take 15g, taking continuously one month is a course for the treatment of.
Embodiment 5
A kind of antigout drug compositions, the raw material comprising following quality is made: Radix Aconiti 50g, Radix Aconiti Kusnezoffii 40g, Radix Aconiti Lateralis Preparata 120g, Herba Asari 15g, Rhizoma Smilacis Glabrae 100g, Rhizoma Dioscoreae Septemlobae 70g, Scorpio 60g, Scolopendra 6g, Radix Et Rhizoma Rhei 50g, Semen Strychni 0.5g, Semen Sinapis Albae 35g, Squama Manis 10g, Herba Epimedii 90g, Fructus Psoraleae 50g, Semen Cuscutae 100g, Semen Astragali Complanati 50g.
Prepare a method for anti-gout drugs capsule based on above-mentioned formula, comprise the following steps:
A, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water are decocted 2 hours after dry again;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, medicated powder is loaded No. 1 capsule, obtain capsule.
The using method of described capsule is: sooner or later respectively take 7, taking continuously one month is a course for the treatment of.
Experimental example
Be below therapeutic test that the compositions of antigout drug described in the present invention did:
(1), testing crew physical data
Select patient with gout 200 example through making a definite diagnosis, in 200 routine patients, M-F is 1:1,18 ~ 64 years old age and in normal distribution, 41 years old mean age.
(2), testing crew diagnosis basis
With national higher medical institute teaching material " internal medicine " and " surgery " for standard, with data such as clinical manifestation, hospital diagnosis conclusion, B ultrasonic reports for foundation, carry out reference, get rid of Other diseases.
(3), test method
200 routine patient with gout are divided into two groups at random: treatment and matched group.In two groups, the number of patient with gout is identical, and the data no difference of science of statistics of age and sex in two groups.
Treatment group uses the decoction in embodiment 3, and according to the using method in embodiment 3, takes 30 days continuously, if cure, stops using.Matched group adopts western medicine, and oral colchicine (0.5mg/ sheet), takes 2 first, and then every 2h takes 1, until when there is the gastrointestinal symptoms such as nausea,vomiting,diarrhea or remission, namely stops using.Be generally 4-8mg, change every day 1 after remission into, take 1 week altogether.Oral allopurinol, each 0.1g, every day 3 times.30 days courses for the treatment of.
(4), curative effect determinate standard
Cure: clinical symptoms disappears completely, recover orthobiosis;
Effective: clinical symptoms partial disappearance, every sign progressively takes a turn for the better;
Invalid: symptom and sign is not improved;
Cure rate and effective percentage all count total effective rate.
(5), result of the test and conclusion
Experimental result is as shown in table 1
Table 1: experimental result table
| Cure rate | Effective percentage | Total effective rate | Inefficiency | |
| Treatment group | 76％ | 16％ | 92％ | 8％ |
| Matched group | 49％ | 26％ | 75％ | 25％ |
Conclusion: the cure rate 76% of antigout drug compositions provided by the invention, total effective rate is 92%; Far above 49% and 75% of Western medicine colchicine common on the market; The excellent effect of antigout drug compositions provided by the invention is described and stablizes.
(6), the concrete case of part:
Lin, female, 42 years old.Suffer from gout 3 years, finger-joint occurs swelling, stiff, lopsided having an intense pain during outbreak.Articulations digitorum manus is red and swollen, and deformity is ugly.Take antigout drug compositions in the present invention after 3 days, redness alleviates, and after 25 days, patient points and recovers normal, no longer pain and so far without recurring.
Zhang, man, 45 years old.Suffer from gout 2 years, adopt the various ways treatments such as doctor trained in Western medicine, cost is high and curative effect is all not obvious.Ankle joint hurt like hell, occur red and swollen phenomenon, night often wakes up with a start, and lives very inconvenient.Take antigout drug compositions in the present invention after 2 days, pain relief, after 18 days, freely, period does not have the side effect such as Nausea and vomiting to patient activity, and so far without recurrence.
Lee, female, 61 years old, suffers from gout 4 years, and right ankle joint is red and swollen, pain of walking; Take antigout drug compositions in the present invention after 6 days, right ankle joint redness disappears, and after continuing to take 30 days, right ankle moving freely.
Bai, man, 58 years old, suffers from gout 2 years, has an intense pain when swelling, outbreak appear in finger-joint.Take antigout drug compositions in the present invention after 4 days, redness alleviates, and after 21 days, patient points and recovers normal, no longer pain and so far without recurring.
It should be noted last that; above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted; although with reference to preferred embodiment to invention has been detailed description; be understood that; the foregoing is only the specific embodiment of the present invention, the protection domain be not intended to limit the present invention, within the spirit and principles in the present invention all; any amendment of making, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. an antigout drug compositions, it is characterized in that, the raw material mainly comprising following weight portion is made: Radix Aconiti 30-60 part, Radix Aconiti Kusnezoffii 30-60 part, Radix Aconiti Lateralis Preparata 30-150 part, Herba Asari 10-30 part, Rhizoma Smilacis Glabrae 40-120 part, Rhizoma Dioscoreae Septemlobae 40-150 part, Scorpio 10-70 part, Scolopendra 4-10 part, Radix Et Rhizoma Rhei 30-60 part, Semen Strychni 0.4-0.9 part, Semen Sinapis Albae 20-40 part, Squama Manis 5-20 part, Herba Epimedii 30-120 part, Fructus Psoraleae 20-120 part, Semen Cuscutae 30-120 part, Semen Astragali Complanati 30-120 part.
2. antigout drug compositions according to claim 1, it is characterized in that, the raw material mainly comprising following weight portion is made: Radix Aconiti 40-50 part, Radix Aconiti Kusnezoffii 40-50 part, Radix Aconiti Lateralis Preparata 60-120 part, Herba Asari 15-25 part, Rhizoma Smilacis Glabrae 60-100 part, Rhizoma Dioscoreae Septemlobae 70-120 part, Scorpio 20-60 part, Scolopendra 6-8 part, Radix Et Rhizoma Rhei 40-50 part, Semen Strychni 0.5-0.8 part, Semen Sinapis Albae 25-35 part, Squama Manis 10-15 part, Herba Epimedii 60-90 part, Fructus Psoraleae 50-90 part, Semen Cuscutae 50-100 part, Semen Astragali Complanati 50-100 part.
3. antigout drug compositions according to claim 1 and 2, is characterized in that, described Radix Aconiti is Radix Aconiti, described Radix Aconiti Kusnezoffii is Radix Aconiti Kusnezoffii, described Radix Aconiti Lateralis Preparata is Radix Aconiti Lateralis.
4. antigout drug compositions according to claim 3 is preparing the application in anti-gout drugs.
5. prepare a method for anti-gout drugs decoction based on antigout drug compositions according to claim 3, it is characterized in that, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, by the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata and other raw materials with decocting, get its decoction liquor, be decoction.
6. method according to claim 5, is characterized in that,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
In step b, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are added surplus stock, and add Rhizoma Zingiberis Recens 15-25 part and Fructus Jujubae 15-20 part, the pure water adding 1500-2500 part again soaks after 1-2 hour, carry out decoction operation again, after getting its decoction liquor, then the pure water adding 1500-2500 part in residue medicinal residues carries out decoction operation and gets its decoction liquor, and the decoction liquor obtained twice mixes and obtains decoction.
7. prepare a method for anti-gout drugs pill based on antigout drug compositions according to claim 3, it is characterized in that, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, the mixture of fecula and water will be added in medicated powder, pill after stirring.
8. method according to claim 7, is characterized in that,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
In step c, medicated powder: water: the ratio of fecula is 10:7:2; First by water and fecula mix homogeneously, heating in after gelatin, then joins in medicated powder; After medicated powder and mixture stir, use machine for making water-bindered pills pill, the quality of ball is 0.1-0.3g.
9. prepare a method for anti-gout drugs pill based on antigout drug compositions according to claim 3, it is characterized in that, comprise the following steps:
A, by Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis with drying again after decocting, obtain Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata;
B, the Radix Aconiti of drying, Radix Aconiti Kusnezoffii, Radix Aconiti Lateralis Preparata are become powder with other raw mill, as medicated powder;
C, medicated powder to be incapsulated, obtain capsule.
10. method according to claim 9, is characterized in that,
In step a, Radix Aconiti, Radix Aconiti Kusnezoffii and Radix Aconiti Lateralis pure water is decocted 1-3 hour;
In step c, the model of described capsule is No. 1, No. 2 or No. 3.
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| CN101138602A (en) * | 2007-04-29 | 2008-03-12 | 丁延全 | Kidney-nourishing gout-treating capsule |
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| CN101040990A (en) * | 2007-04-19 | 2007-09-26 | 王伟 | Chinese traditional medicine compound took orally for treating gout |
| CN101138602A (en) * | 2007-04-29 | 2008-03-12 | 丁延全 | Kidney-nourishing gout-treating capsule |
| CN101716312A (en) * | 2009-11-24 | 2010-06-02 | 青岛市第五人民医院 | Six ingredients gout powder prescription |
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