CN105213774A - A kind of pharmaceutical composition for the treatment of chronic heart failure - Google Patents

Abstract

Treat a pharmaceutical composition for chronic heart failure, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Panacis Quinquefolii 5-25 part, Radix Ophiopogonis 8-30 part, Radix Glycyrrhizae Preparata 5-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-30 part.Pharmaceutical preparation of the present invention has the raw arteries and veins effect of QI invigorating.Prescription is simple, and scientific formulation is reasonable, and treatment chronic heart failure is evident in efficacy.

Description

A kind of pharmaceutical composition for the treatment of chronic heart failure

Technical field

The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of chronic heart failure.

Background technology

Heart failure is the myocardial damage because any reasons such as myocardial infarction, cardiomyopathy, hemodynamics overload, inflammation cause, and causes the change of cardiac structure and function, finally causes ventricular pump blood or full hypofunction.Clinical main manifestations is dyspnea, weak and body retention.Chronic heart failure (CHF) refers to the heart failure state of sustainable existence, can stablize, worsens or lose compensatory.The target for the treatment of heart failure is not only and is improved symptom, improves the quality of living, and for the mechanism of myocardial remodelling, delays and prevent the development of myocardial remodelling, reduce admission rate and the mortality rate of heart failure.

Most patients has heart disease medical history, will significantly improve heart failure prognosis for etiological treatment.Coronary heart disease, hypertension and senile degenerative heart valve disease are the Etiologicals of old patients with heart failure, and the diseases such as rheumatic valvular heart disease, dilated cardiomyopathy, acute severe myocarditis are year main causes for the lighter's heart failure.Contractility heart failure commonly encountered diseases, because coronary heart disease, actively rebuilds development and deterioration that blood fortune can prevent heart failure; Diastolic (or preserved ejection fraction) heart failure commonly encountered diseases, because hypertension, controls blood pressure of crucial importance, otherwise heart failure progress rapidly, also can bring out acute heart failure.

Summary of the invention

The present invention aim to provide a kind ofly to have no side effect, the Chinese medicine composition of eutherapeutic treatment chronic heart failure.

For achieving the above object, a kind of pharmaceutical composition for the treatment of chronic heart failure of the present invention, its specific embodiments is:

A kind of pharmaceutical composition for the treatment of chronic heart failure of the present invention, is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Panacis Quinquefolii 5-25 part, Radix Ophiopogonis 8-30 part, Radix Glycyrrhizae Preparata 5-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-30 part.

A kind of pharmaceutical composition for the treatment of chronic heart failure of the present invention, is characterized in that these pharmaceutical composition parts by weight are counted: Radix Panacis Quinquefolii 8-22 part, Radix Ophiopogonis 10-25 part, Radix Glycyrrhizae Preparata 8-15 part, Fructus Jujubae 12-25 part, Radix Pseudostellariae 20-28 part.

Pharmaceutical composition described in any one of the present invention, is characterized in that, described preparation is oral formulations.

4. preparation according to claim 3, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, tablet, electuary and oral liquid.

Preparation of the present invention, is characterized in that, described preparation is tablet.

Preparation of the present invention, is characterized in that, the preparation method of this tablet is: 1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae wears into coarse powder, mixing, with 4-8 times amount 55%-75% ethanol as solvent, dipping 8-16 hour, slowly percolation, collect 4-8 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 12 hours;

2) medicinal residues add 4-8 times amount soak by water 1-3 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, adds cane sugar powder and dextrin, granulates, 80 DEG C of dryings, let cool, mixing, tabletting, to obtain final product.

The each component pharmacology analysis of prescription of the present invention:

Radix Panacis Quinquefolii: cool in nature, sweet in the mouth, micro-hardship, GUIXIN, lung, kidney channel, have effect of tonifying the lung pathogenic fire reducing, nourishing the stomach to promote the production of body fluid.

Radix Ophiopogonis: have another name called dwarf lilyturf, book band grass, Radix Ophiopogonis, Radix Ophiopogonis, sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.

Radix Glycyrrhizae Preparata: sweet is flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly spleen reinforcing stomach function regulating, Yiqi and vein recovery.

Fructus Jujubae: sweet in the mouth is warm in nature, return taste warp, has the function of invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the mitigation property of medicine.

Radix Pseudostellariae: sweet in the mouth, micro-hardship; Property is put down.Return spleen, lung meridian.Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.

[plus-minus] deficiency of heart-YANG person is with warm heart side's (Radix Ginseng Rubra, Radix Aconiti Lateralis Preparata, Semen Coicis, Exocarpium Citri Rubrum etc.), and deficiency of heart-yin person is with the side of nourishing heart (Radix Ginseng, Radix Ophiopogonis, Rhizoma Pinelliae Preparatum, Poria, Typhonium flagelliforme (Lodd.) Blume etc.); Except two sides, yang deficiency also can close Ramuli Cinnamomi and Glycyrrhizae Decoction or shenfu decoction with decoction of four noble drugs, adds Herba Ipomoeae Cairicae, Radix Astragali, Semen Ziziphi Spinosae, Semen Platycladi etc.; Deficiency of YIN SHENGMAI SAN adds Radix Adenophorae (Radix Glehniae), Rhizoma Polygonati Odorati, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori etc.Blood stasis adds by Semen Persicae drink (Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Clematidis) or SHIXIAO SAN; Edema notably adds by WULING SAN, WUPI YIN; Double exogenous cough person Jia Herba Siegesbeckiae, Semen Armeniacae Amarum, Radix Asteris, the Radix Stemonae; Dyspnea and cough with excessive sputum person adds Fructus Perillae, Semen Sinapis Albae, Arisaema Cum Bile, Pumex; Weight in wet base tongue thick one adds Semen Coicis, Testa dolichoris; The danger disease that wish of breathing with cough takes off then is referred and synthesized dense the decocting of Zhen Wu Tang, Decoction for strengthening the Spleen-Yang with Koryo and is taken in small doses at short intervals, and coordinate intravenous injection Korean Ginseng pin, Shenfu pin, or Rhizoma Zingiberis Recens pin is with invigorating QI to relieve exhaustion.

Beneficial effect of the present invention is:

1. prescription scientific formulation, evident in efficacy.

2. prescription crude drug source is wide, and technique is simple, is applicable to large-scale production, has industrialization prospect.

Detailed description of the invention

The present invention is further illustrated below for embodiment.

Embodiment 1

Prescription:

Radix Panacis Quinquefolii 10 parts, Radix Ophiopogonis 12 parts, Radix Glycyrrhizae Preparata 12 parts, 15 parts, Fructus Jujubae, Radix Pseudostellariae 25 parts.

The preparation method of tablet is:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae wears into coarse powder, and mixing, with 5 times amount 60% ethanol as solvent, floods 12 hours, slowly percolation, collect 5 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 12 hours;

2) medicinal residues add 6 times amount soak by water 1 hour, and filter, filtrate is concentrated into the clear paste that relative density is 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, and mixing, adds cane sugar powder and dextrin, and granulate, 80 DEG C of dryings, let cool, and mixing, tabletting, to obtain final product.

Embodiment 2

Prescription:

Radix Panacis Quinquefolii 10 parts, Radix Ophiopogonis 10 parts, Radix Glycyrrhizae Preparata 10 parts, 20 parts, Fructus Jujubae, Radix Pseudostellariae 28 parts.

Preparation technology:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae wears into coarse powder, and mixing, with 5 times amount 60% ethanol as solvent, floods 12 hours, slowly percolation, collect 5 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 12 hours;

2) medicinal residues add 6 times amount soak by water 1 hour, and filter, filtrate is concentrated into the clear paste that relative density is 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, and mixing, adds cane sugar powder and dextrin, and granulate, 80 DEG C of dryings, let cool, and mixing, granule processed, to obtain final product.

Embodiment 3

Prescription:

Radix Panacis Quinquefolii 8 parts, Radix Ophiopogonis 12 parts, Radix Glycyrrhizae Preparata 12 parts, 15 parts, Fructus Jujubae, Radix Pseudostellariae 25 parts.

Decoction preparation technology:

First, by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae eight taste medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm); Secondly, be placed on by medicine on fire, endure out with big fire, timing after boiling, decocts 60 minutes; Finally, first time fried medicinal liquid is poured out, add appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, about the about 30 minutes time of second time decoction.To mix with second time medicinal liquid by medicinal liquid for the first time, obtain decoction of the present invention.

Embodiment 4

Prescription:

Radix Panacis Quinquefolii 10 parts, Radix Ophiopogonis 12 parts, Radix Glycyrrhizae Preparata 12 parts, 15 parts, Fructus Jujubae, Radix Pseudostellariae 25 parts.

Capsule preparation technology:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae wears into coarse powder, and mixing, with 5 times amount 60% ethanol as solvent, floods 12 hours, slowly percolation, collect 5 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 12 hours;

2) medicinal residues add 6 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, adds cane sugar powder and dextrin, granulates, 80 DEG C of dryings, let cool, mixing, dry, filled capsules and get final product.

Chen, man, 58 years old, has history of coronary heart disease, and run exercise tolerance decline morning and occur dyspnea or weak, leg edema, examination in hospital is diagnosed as chronic heart failure, and take Tablets 1 month, symptom is eased.

It should be noted that; above-described embodiment is only preferred embodiment of the present invention; be not used for limiting protection scope of the present invention; protection scope of the present invention is as the criterion with claims; equivalent replacement done on the basis of technique scheme or substitute, all belongs to protection scope of the present invention.

Claims (6)

1. treat a pharmaceutical composition for chronic heart failure, it is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix Panacis Quinquefolii 5-25 part, Radix Ophiopogonis 8-30 part, Radix Glycyrrhizae Preparata 5-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-30 part.

2. a kind of pharmaceutical composition for the treatment of chronic heart failure according to claim 1, is characterized in that these pharmaceutical composition parts by weight are counted: Radix Panacis Quinquefolii 8-22 part, Radix Ophiopogonis 10-25 part, Radix Glycyrrhizae Preparata 8-15 part, Fructus Jujubae 12-25 part, Radix Pseudostellariae 20-28 part.

3. the pharmaceutical composition according to any one of claim 1-2, is characterized in that, described preparation is oral formulations.

4. preparation according to claim 3, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, tablet, electuary and oral liquid.

5. preparation according to claim 4, is characterized in that, described preparation is tablet.

6. preparation according to claim 5, is characterized in that, the preparation method of this tablet is: 1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Radix Pseudostellariae wears into coarse powder, mixing, with 4-8 times amount 55%-75% ethanol as solvent, dipping 8-16 hour, slowly percolation, collect 4-8 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 12 hours;

2) medicinal residues add 4-8 times amount soak by water 1-3 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, adds cane sugar powder and dextrin, granulates, 80 DEG C of dryings, let cool, mixing, tabletting, to obtain final product.