CN105213734A - A kind of alleviation 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method - Google Patents

A kind of alleviation 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method Download PDF

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CN105213734A
CN105213734A CN201510728868.8A CN201510728868A CN105213734A CN 105213734 A CN105213734 A CN 105213734A CN 201510728868 A CN201510728868 A CN 201510728868A CN 105213734 A CN105213734 A CN 105213734A
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parts
herba
aloe
chinese medicine
cortex
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黄瑞雪
胡建安
何建军
范岚
段燕英
罗怀青
黄波
朱春晖
石峰
李继猛
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Central South University
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Central South University
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Abstract

The present invention relates to a kind of compound Chinese medicinal preparation and preparation method and application, particularly one is alleviated 131the Chinese medicine preparation of radiation after iodine therapy thyroid carcinoma and preparation method.The raw material of described Chinese medicine preparation, comprises according to the mass fraction: Cortex sophorae 10-40 part, Herba Lycopodii 20-120 part, Herba Selaginellae 10-40 part, Herba Taraxaci 10-20 part, Poria 10-20 part, Flos Lonicerae 10-20 part, Aloe 10-20 part.The medicament that the present invention develops has alleviates heavy dose 131efficacy of irradiation after iodine therapy thyroid carcinoma, is applicable to heavy dose 131after iodine therapy thyroid carcinoma, radiation is on the impact at other positions of health, also can alleviate medical personnel, the raying of family members institute, safe without toxic side effect.

Description

A kind of alleviation 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation and preparation method and application, particularly one is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method.
Background technology
Thyroid carcinoma is modal malignant tumor in hormonal system and tumor of head and neck.Annual thyroid carcinoma new cases account for 1% ~ 5% of all pathogenesis of cancer, and female thyroid carcinoma morbidity is higher than male, and be about the age of onset versus young of 3 times of male, thyroid carcinoma, sickness rate rises with the growth at age.Over nearly 30 years, thyroid cancer incidence maintains sustained and rapid growth.According to global cancer condition data display in 2012, global thyroid carcinoma average attack rate was 4.0/10 ten thousand.The Residents thyroid cancer incidence in 2010 of BeiJing, China's report is 9.9/10.Chinese city thyroid cancer incidence is higher than global average onset level,
131iodine ( 131i) be a kind of radiopharmaceutical, be the isotope of iodine, have identical chemical property with iodine, but different from common iodine, it can launch gamma-rays for video picture and the β ray that is used for the treatment of, thus plays the effect of Diagnosis and Treat.Thyroid carcinoma is modal tumor in human endocrinological's tumor, and wherein the overwhelming majority is the malignant tumor of had better differentiation.Differentiated thyroid carcinoma cell generally all remains the characteristic that normal thyroid cell could absorb and utilize iodide ion, and when after thyroidectomy, Thyroid disease has picked-up 131the function of iodine.When patient is oral a certain amount of 131iodine solution or capsule) after, remaining thyroid and metastasis can highly be absorbed 131iodine, passes through 131the β ray that iodine is launched and r ray, can effectively remove remaining parathyroid tissue and killing off tumor cells, this method is just called " radioiodine therapy ". 131the physical half time of iodine is 8.04 days, in patient body 131iodine hold-up≤1.11GB (30mCi) Shi Caineng leaves hospital.Enter in body 131iodine can be discharged from the secretions such as respiratory tract, perspiration, urine, saliva, causes other positions in patient body to be also vulnerable to 131iodine radiolesion.The used medicated clothing of patient, bedding and clothing are placed laundry room after month and are washed separately; Special handling will be done by the rubbish that patient body fluid is polluted.In radioactivity 131during iodine therapy, some radiation side reactions (as epigastric discomfort, nauseating, weak, incidence swelling etc.) can be there are to some extent in patient, patient may occur that menoxenia, xerostomia, eye are dry in a short time, degradation side reaction under hemogram, even have patient through repeatedly, long-term, high-dose 131the situation that bone marrow depression etc. is more serious has been there is, at every turn after iodine therapy 131the interval time of iodine therapy is generally 3 ~ 6 months, guarantees that patient has time enough to obtain certain rehabilitation longer interval time, avoids the accumulative effect of radiation hazradial bundle.
At present for radioactivity 131especially to treat during iodine therapy thyroid cancer patients in latter 72 hours to self other organ, to surrounding population and the larger phenomenon of radiation harmfulness, and the radiation side effect that patient occurs is as nauseating, weak, incidence swelling, hemogram decline, myelosuppressive phenomenon, there is no effective method at present.Medical personnel advise that patient is in radioactivity usually 131great quantity of water drinking after iodine therapy, forbids edible containing iodine food etc. measure, many for the invention of antineoplastic Chinese medicine at present, but for thyroid carcinoma 131the invention alleviating patient irradiation's occurrence situation after iodine therapy has no report.
The nature reparation of radiation damage is a very long process, assists to prevent and promote that it is necessary for recovering if can give suitable medicine.Some drug toxicitys with Study On The Radioprotective are comparatively large, and herbal toxic effect is little, and people trend towards starting with from natural drug little to toxicity to be developed, are applicable to the medicine of clinical control radiation injury.Chinese medicine is the same with food is derive from the mineral of the Nature, plant, animal drugs, and do not have toxic and side effects, Chinese medicine does not have Drug resistance, can continue to use.But up to the present also for weakening there are no employing compound Chinese medicinal preparation 131the record of iodine radiation hazradial bundle.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of and alleviate 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method.
The present invention's one is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, its raw material comprises following component in mass fraction:
Cortex sophorae 10-40 part, preferably 15-40 part;
Herba Lycopodii 20-120 part, preferably 40-120 part;
Herba Selaginellae 10-40 part, preferably 15-40 part;
Cortex Moutan 10-20 part;
Herba Taraxaci 10-20 part;
Poria 10-20 part;
Flos Lonicerae 10-20 part;
Aloe 10-20 part.
The present invention's one is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, the preferred ingredient proportioning of its raw material comprises following three kinds of schemes.
Scheme one
In mass fraction, its raw material comprises following component:
Cortex sophorae 40 parts, Herba Lycopodii 120 parts, Herba Selaginellae 40 parts, Cortex Moutan 20 parts, Herba Taraxaci 20 parts, 20 parts, Poria, Flos Lonicerae 20 parts, Aloe 20 parts.
Scheme two
In mass fraction, its raw material comprises following component:
Cortex sophorae 34 parts, Herba Lycopodii 100 parts, Herba Selaginellae 34 parts, Cortex Moutan 18 parts, Herba Taraxaci 18 parts, 18 parts, Poria, Flos Lonicerae 18 parts, Aloe 18 parts.
Scheme three
In mass fraction, its raw material comprises following component:
Cortex sophorae 15 parts, Herba Lycopodii 40 parts, Herba Selaginellae 15 parts, Cortex Moutan 10 parts, Herba Taraxaci 10 parts, 10 parts, Poria, Flos Lonicerae 10 parts, Aloe 10 parts.
The present invention's one is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, described Aloe is selected from the one in Aloe vulgaris, Aloe vera L.var. chinensis(Haw.)Berg., upper agricultural university leaf Aloe, Aloe arborescens var. natalensis, aloe ferrox, A.saponaria.
The present invention's one is alleviated 131after iodine therapy thyroid carcinoma, the preparation method of the Chinese medicine preparation of radiation untoward reaction, comprises the steps:
Step one
Join by the component of design and get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan, Herba Taraxaci, Poria, Flos Lonicerae, Aloe;
Step 2
By join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, add water after 50-100 DEG C, preferably 90-100 DEG C, more preferably 95-100 DEG C extract, filter, filtrate is concentrated into paste at 30-60 DEG C, obtains mixing creme;
Step 3
Smashing to pieces joining the Poria got, being placed in mortar and grinding into powder, obtain-200 object Poria fine powders;
Step 4
Clean joining the Flos Lonicerae decontamination got, put in pot, the water content being fried to Flos Lonicerae is less than or equal to 5wt%, takes out after cooling, grinds into powder, obtains-160 object Flos Loniceraes and concocts fine powder, for subsequent use; The temperature of described parch is 120-180 DEG C;
Step 5
Smash to pieces joining the Aloe of getting, in mass ratio, Aloe: water=20-80:30-70, filter after the grinding that adds water, filtrate is Aloe lapping liquid;
Step 6
Being placed in crucible by joining the Herba Taraxaci got, cooling after 200-300 DEG C of calcining 0.5-1h, grinding, obtain-180 object Herba Taraxacis and concoct fine powder,
Step 7
After step 2 gained mixing creme, step 3 gained-200 object Poria fine powder, step 4 gained-160 object Flos Lonicerae are concocted fine powder, step 5 gained Aloe lapping liquid, step 6 gained-180 object Herba Taraxaci process of preparing Chinese medicine fine powder mix homogeneously, 45-55 DEG C of drying, obtain compound Chinese medicinal preparation.
The present invention's one is alleviated 131the preparation method of the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, in step 2, by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, first press Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 7-9 times of Cortex Moutan gross mass, add distilled water, soak after 3-4 hour, after 50-100 DEG C, preferably 90-100 DEG C, more preferably 95-100 DEG C extract 2-3 hours, filter, obtain the first filtrate and the first filtering residue, the first filtrate is for subsequent use; First filtering residue proceeds to extract; First filtering residue proceed extraction complete after filtration, obtain the second filtrate and the second filtering residue; Second filtrate is for subsequent use, and the second filtering residue proceeds to extract; Second filtering residue proceeds after extraction completes, to obtain the 3rd filtrate and the 3rd filtering residue; After first filtrate, the second filtrate, the 3rd filtrate mixing, be concentrated into paste in 30-60 DEG C, obtain mixing creme;
First filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan gross mass 4-6 doubly add distilled water then 50-100 DEG C, be preferably 90-100 DEG C, more preferably 95-100 DEG C extract after 1-2 hour, filter;
Second filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan gross mass 2-3 doubly add distilled water then 50-100 DEG C, be preferably 90-100 DEG C, more preferably 95-100 DEG C extract after 1-2 hour, filter.
Conveniently pack, take, generally will obtain after compound Chinese medicinal preparation carries out ultraviolet sterilization, making capsule.Also can be made into decoction, granule, tablet or mixture.
The present invention's one is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma also has certain effect to other isotope therapy.
Principle and advantage
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, each taste Chinese medicine carries out compatibility according to the prescription rule of monarch, compound Chinese medicinal preparation is adjusted by the negative and positive to body, QI and blood, by the synergism of component, demonstrates radioprotective, repairs the effect of matrix fast.The medicine that the present invention develops has the effect alleviating patient irradiation's harm, is specially adapted to 131iodine therapy thyroid cancer patients, safe without toxic side effect, short treating period, instant effect.
Detailed description of the invention
Embodiment 1
In mass fraction, get following raw material components:
Cortex sophorae 40 parts, Herba Lycopodii 120 parts, Herba Selaginellae 40 parts, Cortex Moutan 20 parts, Herba Taraxaci 20 parts, 20 parts, Poria, Flos Lonicerae 20 parts, Aloe 20 parts.
Its preparation method, comprises the steps:
Step one
Join by the component of design and get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan, Herba Taraxaci, Poria, Flos Lonicerae, Aloe;
Step 2
By join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, first press Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 7 times of Cortex Moutan gross mass, add distilled water, soak after 3 hours, after extracting 2 hours at 100 DEG C, filter, obtain the first filtrate and the first filtering residue, the first filtrate is for subsequent use; First filtering residue proceeds to extract; First filtering residue proceed extraction complete after filtration, obtain the second filtrate and the second filtering residue; Second filtrate is for subsequent use, and the second filtering residue proceeds to extract; Second filtering residue proceeds after extraction completes, to obtain the 3rd filtrate and the 3rd filtering residue; After first filtrate, the second filtrate, the 3rd filtrate mixing, be concentrated into paste in 60 DEG C, obtain mixing creme;
First filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 4 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 100 DEG C, filter;
Second filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 2 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 100 DEG C, filter;
Step 3
Smashing to pieces joining the Poria got, being placed in mortar and grinding into powder, obtain-200 object Poria fine powders;
Step 4
Clean joining the Flos Lonicerae decontamination got, put in pot, the water content being fried to Flos Lonicerae is less than or equal to 5wt%, takes out after cooling, grinds into powder, obtains-160 object Flos Loniceraes and concocts fine powder, for subsequent use; The temperature of described parch is 150 DEG C;
Step 5
Smash to pieces joining the Aloe of getting, in mass ratio, Aloe: water=2:8, filter after the grinding that adds water, filtrate is Aloe lapping liquid;
Step 6
Being placed in crucible by joining the Herba Taraxaci got, cooling after 200 DEG C of calcining 0.5h, grinding, obtain-180 object Herba Taraxacis and concoct fine powder,
Step 7
After step 2 gained mixing creme, step 3 gained-200 object Poria fine powder, step 4 gained-160 object Flos Lonicerae are concocted fine powder, step 5 gained Aloe lapping liquid, step 6 gained-180 object Herba Taraxaci process of preparing Chinese medicine fine powder mix homogeneously, after 45 DEG C of dryings, ultraviolet-sterilization, is assembled into capsule.
Animal data:
1. animal hematopoietic function recovery experiment
Healthy ICR mice 80, body weight is 18-20g, and male and female half and half are provided by institute of lab animals of Central South University.Animal random packet, experiment establishes blank group, radiation group and compound Chinese medicinal preparation group, alone Herba Lycopodii group, alone Cortex sophorae group, alone Cortex Moutan group six groups.
Oral administration gavage administration, 0.2g/, once a day,
Blank group gives distilled water; Radiation group is the medullary thyroid carcinoma cell strain (1 × 10 that suspends with 1.0ml normal saline of subcutaneous injection first 6cell/only).The animal of injection tumor cell grows up to the tumor body that can touch after 10 days; Then thyroid carcinoma mice is given 131iodine medicine, compound Chinese medicinal preparation group is the medullary thyroid carcinoma cell strain (1 × 10 that suspends with 1.0ml normal saline of subcutaneous injection first 6cell/only).The animal of injection tumor cell grows up to the tumor body that can touch after 10 days.Then thyroid carcinoma mice is given 131compound Chinese medicinal preparation aqueous solution is given in one hour after iodine medicine.Alone Herba Lycopodii group is the administration of Herba Lycopodii oral administration gavage, alone Cortex sophorae group is Cortex sophorae gastric infusion, alone Cortex Moutan group is Cortex Moutan gastric infusion.18th day, take Mouse Weight, get blood in orbital venous plexus, add anticoagulant EDTA.Na, fully automatic blood cytoanalyze measures leukocyte (WBC) and platelet (PLT).Cervical dislocation puts to death white mice, separates both sides femur.Whole medullary cell gone out by the acetic acid of side femur 10ml3% (V/V), and on cytometry dish, count the cell number of four block plaid under ultramicroscope, the number of gained is multiplied by 2.5x10 4, be the bonemarrow nucleated cells number (BMNC) in a femur.Opposite side femur, uses 10mlCaCl 2whole bone marrow pours in centrifuge tube by solution (0.005M), the centrifugal 15min of 2500r/min, abandon supernatant, precipitate is added 5mlHCl solution (0.2mol/L) fully to mix, 90 DEG C of heating 15min, cooling, filters, filtrate measures trap (A) with ultraviolet-uisible spectrophotometer 268nm, represents the content of femur bone marrow DNA.
Alone Herba Lycopodii group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 1; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex sophorae group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 1; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex Moutan group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 1; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1.
Table 1
In table, * represents: compare with radiation group, difference has significance therebetween.
Because hemopoietic system is the most responsive to radiation, be subject to obvious suppression by the hemopoietic function according to rear mice.The recovery of hemopoietic function is the key factor of prognosis.The change of bone marrow DNA content represents the ability of mouse hemopoietic functional rehabilitation.Compare with blank group, take radioactivity 131the mice of iodine, numeration of leukocyte reduces, and platelet count reduces, and BMNC bonemarrow nucleated cells number increases, and bone marrow DNA content reduces.Compare with radiation group, Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number, raises bone marrow DNA content.Show the hemopoietic function can improving mice.Illustrate that Chinese medicine preparation has certain protective effect to radiation damage, also have certain repair to normal cell simultaneously.
Single
Cooperative experiment finds, compares, take radioactivity with blank group 131the mice of iodine, numeration of leukocyte reduces, and platelet count reduces, and BMNC bonemarrow nucleated cells number increases, and bone marrow DNA content raises.Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number.But alone wherein a certain Chinese medicine, it than Chinese traditional compound medicine weak effect, illustrates that Chinese traditional compound medicine has synergism to the protective effect of radiation damage compared with alone a certain Chinese medicine in raising number of white blood cells, platelet (PLT) number effect.
Clinical data:
1, case selection:
Select 131iodine therapy patient 56 example carries out clinical observation, and patient is divided into two groups immediately, protection group 28 example, wherein man 10 example, female 18 example, 25-60 years old ages, 35.3 years old mean age, disease time 1-10 years; Matched group 28 example, wherein man 9 example, women 19 example, 25-60 years old ages, 34.8 years old mean age, the course of disease 1-10 years old; Two groups of patient cases are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, Therapeutic Method:
Patient for protection group applies Chinese medicine preparation of the present invention, oral, each 2, every day 3 times, within 10 days, is a course for the treatment of.
Matched group does not take Chinese medicine preparation of the present invention, follows the doctor's advice and drinks water more.
3, Outcome measure:
Cure: the transference cures such as skin is dark yellow, the damage of nausea and vomiting, hematopoietic cell, high liver fire; In high spirits, health is fully recovered.
Effective: above-mentioned symptom is alleviated to some extent, in high spirits, health is fully recovered.
Invalid: disease is unchanged.
4, therapeutic effect:
Protection group: cure 20 examples, take a turn for the better 6 examples, and invalid 2 examples, cure rate is 71.4%.Total effective rate is 92.9%.
Matched group: cure 11 examples, take a turn for the better 8 examples, and no effect 9, cure rate is 39.3%.Total effective rate is 67.9%.
Above result display, the cure rate of protection group and total effective rate are apparently higher than matched group.
5, model case citing:
1, Lee's ××, female, 30 years old, civil servant, people from Changsha.Patient comes to seek medical advice because of thyroid carcinoma, applies 131lassitude, appears that skin is dark yellow, in iodine therapy, the subcutaneous easily symptom such as hemorrhage.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, transference cure, follows up a case by regular visits to, and symptom is without recurrence.
2, Korea Spro's ××, female, 34 years old, profession, Chenzhou, Hunan Province people.Patient suffers from thyroid carcinoma and merges renal carcinoma, application 131iodine therapy occurs that skin shades, degradation symptom under lassitude, hemogram.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, health is rehabilitation gradually, and symptom is obviously alleviated, and continues to take 2 courses for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
3, Liu's ××, female, 39 years old, doctor, people from Liaoning.Patient because of the lower work of long campaigns perspective, suffers from thyroid carcinoma, application for a long time 131there is yellowing of the skin after iodine therapy, play the symptoms such as small pox, lethargy.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and after continuing to take 3 courses for the treatment of, above transference cure, physical recovery is healthy, not recurrence.
4, king's ××, female, 42 years old, thyroid carcinoma, application 131there is the symptoms such as skin is dark yellow, high liver fire after iodine therapy, and frequent nausea and vomiting.Recommend through people, take Chinese medicine preparation of the present invention 3 the symptom course for the treatment of and obviously alleviate, after continuing to take 2 courses for the treatment of, transference cure, follows up a case by regular visits to not recurrence.
Embodiment 2
In mass fraction, get following raw material components:
Cortex sophorae 34 parts, Herba Lycopodii 100 parts, Herba Selaginellae 34 parts, Cortex Moutan 18 parts, Herba Taraxaci 18 parts, 18 parts, Poria, Flos Lonicerae 18 parts, Aloe 18 parts.
Its preparation method, comprises the steps:
Step one
Join by the component of design and get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan, Herba Taraxaci, Poria, Flos Lonicerae, Aloe;
Step 2
By join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, first press Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 5 times of Cortex Moutan gross mass, add distilled water, soak after 4 hours, after extracting 3 hours at 95 DEG C, filter, obtain the first filtrate and the first filtering residue, the first filtrate is for subsequent use; First filtering residue proceeds to extract; First filtering residue proceed extraction complete after filtration, obtain the second filtrate and the second filtering residue; Second filtrate is for subsequent use, and the second filtering residue proceeds to extract; Second filtering residue proceeds after extraction completes, to obtain the 3rd filtrate and the 3rd filtering residue; After first filtrate, the second filtrate, the 3rd filtrate mixing, be concentrated into paste in 45 DEG C, obtain mixing creme;
First filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 4 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 95 DEG C, filter;
Second filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 2 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 95 DEG C, filter;
Step 3
Smashing to pieces joining the Poria got, being placed in mortar and grinding into powder, obtain-200 object Poria fine powders;
Step 4
Clean joining the Flos Lonicerae decontamination got, put in pot, the water content being fried to Flos Lonicerae is less than or equal to 5wt%, takes out after cooling, grinds into powder, obtains-160 object Flos Loniceraes and concocts fine powder, for subsequent use; The temperature of described parch is 160 DEG C;
Step 5
Smash to pieces joining the Aloe of getting, in mass ratio, Aloe: water=2.5:7.5, filter after the grinding that adds water, filtrate is Aloe lapping liquid;
Step 6
Being placed in crucible by joining the Herba Taraxaci got, cooling after 240 DEG C of calcining 0.8h, grinding, obtain-180 object Herba Taraxacis and concoct fine powder,
Step 7
After step 2 gained mixing creme, step 3 gained-200 object Poria fine powder, step 4 gained-160 object Flos Lonicerae are concocted fine powder, step 5 gained Aloe lapping liquid, step 6 gained-180 object Herba Taraxaci process of preparing Chinese medicine fine powder mix homogeneously, after 50 DEG C of dryings, ultraviolet-sterilization, is assembled into capsule.
Animal data:
1. animal hematopoietic function recovery experiment
Healthy ICR mice 80, body weight is 18-20 gram, and male and female half and half are provided by institute of lab animals of Central South University.Animal random packet, blank group, radiation group and compound Chinese medicinal preparation group three groups are established in experiment.
Oral administration gavage administration, 0.2g/, once a day,
Blank group gives distilled water; Radiation group is the medullary thyroid carcinoma cell strain (1 × 106 cell/only) that suspends with 1.0ml normal saline of subcutaneous injection first.The animal of injection tumor cell grows up to the tumor body that can touch after 10 days; Then thyroid carcinoma mice is given 131iodine medicine, compound Chinese medicinal preparation group is the medullary thyroid carcinoma cell strain (1 × 10 that suspends with 1.0ml normal saline of subcutaneous injection first 6cell/only).The animal of injection tumor cell grows up to the tumor body that can touch after 10 days.Then compound Chinese medicinal preparation aqueous solution is given in one hour after giving thyroid carcinoma mice 131 iodine medicine.18th day, take Mouse Weight, get blood in orbital venous plexus, add anticoagulant EDTA.Na, fully automatic blood cytoanalyze measures leukocyte (WBC) and platelet (PLT).Cervical dislocation puts to death white mice, separates both sides femur.Whole medullary cell gone out by the acetic acid of side femur 10ml3% (V/V), and on cytometry dish, count the cell number of four block plaid under ultramicroscope, the number of gained is multiplied by 2.5x10 4, be the bonemarrow nucleated cells number (BMNC) in a femur.Opposite side femur, uses 10mlCaCl 2whole bone marrow pours in centrifuge tube by solution (0.005M), the centrifugal 15min of 2500r/min, abandon supernatant, precipitate is added 5mlHCl solution (0.2mol/L) fully to mix, 90 DEG C of heating 15min, cooling, filters, filtrate measures trap (A) with ultraviolet-uisible spectrophotometer 268nm, represents the content of femur bone marrow DNA.
Alone Herba Lycopodii group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex sophorae group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex Moutan group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1.
Table 2
* represent and compare with radiation group, difference has significance therebetween.
Because hemopoietic system is the most responsive to radiation, be subject to obvious suppression by the hemopoietic function according to rear mice.The recovery of hemopoietic function is the key factor of prognosis.The change of bone marrow DNA content represents the ability of mouse hemopoietic functional rehabilitation.Compare with blank group, take radioactivity 131the mice of iodine, numeration of leukocyte reduces, and platelet count reduces, and BMNC bonemarrow nucleated cells number increases, and bone marrow DNA content raises.Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number.Show the hemopoietic function can improving mice.Illustrate that Chinese medicine preparation has certain protective effect to radiation damage, also have certain repair to normal cell simultaneously.
Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number.But alone wherein a certain Chinese medicine, it than Chinese traditional compound medicine weak effect, illustrates that Chinese traditional compound medicine has synergism to the protective effect of radiation damage compared with alone a certain Chinese medicine in raising number of white blood cells, platelet (PLT) number effect.
Clinical data:
1, case selection:
Select 131iodine therapy patient 56 example carries out clinical observation, and patient is divided into two groups immediately, protection group 28 example, wherein man 10 example, female 18 example, 25-60 years old ages, 35.3 years old mean age, disease time 1-10 years; Matched group 28 example, wherein man 9 example, women 19 example, 25-60 years old ages, 34.8 years old mean age, the course of disease 1-10 years old; Two groups of patient cases are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, Therapeutic Method:
Patient for protection group applies Chinese medicine preparation of the present invention, oral, each 2, every day 3 times, within 10 days, is a course for the treatment of.
Matched group does not take Chinese medicine preparation of the present invention, follows the doctor's advice and drinks water more.
3, Outcome measure:
Cure: the transference cures such as skin is dark yellow, the damage of nausea and vomiting, hematopoietic cell, high liver fire; In high spirits, health is fully recovered.
Effective: above-mentioned symptom is alleviated to some extent, in high spirits, health is fully recovered.
Invalid: disease is unchanged.
4, therapeutic effect:
Protection group: cure 22 examples, take a turn for the better 2 examples, and invalid 4 examples, cure rate is 78.5%.Total effective rate is 85.7%.
Matched group: cure 12 examples, take a turn for the better 8 examples, and invalid 8 examples, cure rate is 42.8%.Total effective rate is 71.4%.
Above result display, the cure rate of protection group and total effective rate are apparently higher than matched group.
5, model case citing:
1, Liu's ××, female, 32 years old, General Office of Finance civil servant, people from Changsha.Patient comes to seek medical advice because of breast carcinoma complicated with thyroid cancer, applies 131lassitude, appears that skin is dark yellow, in iodine therapy, subcutaneous easily hemorrhage, the symptoms such as numeration of leukocyte is on the low side.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, transference cure, numeration of leukocyte recovers normal, and follow up a case by regular visits to, symptom is without recurrence.
2, Korea Spro's ××, female, 33 years old, profession, people from Wangcheng, Hunan.Patient suffers from thyroid carcinoma and merges renal carcinoma, application 131iodine therapy occurs that skin shades, degradation symptom under lassitude, hemogram.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, health is rehabilitation gradually, and symptom is obviously alleviated, and continues to take 1 course for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
3, old ××, female, 46 years old, doctor, people from Liaoning, suffered from thyroid carcinoma, occurs yellowing of the skin after applying 131 iodine therapies, subcutaneous many places congestion, insomnia, the symptoms such as lethargy.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and after continuing to take 2 courses for the treatment of, above transference cure, physical recovery is healthy, not recurrence.
4, king's ××, female, 40 years old, thyroid carcinoma, application 131occur after iodine therapy that skin is dark yellow, high liver fire, etc. symptom, and frequent nausea and vomiting.Recommend through people, take Chinese medicine preparation of the present invention 2 the symptom course for the treatment of and obviously alleviate, after continuing to take 2 courses for the treatment of, transference cure, follows up a case by regular visits to not recurrence.
Embodiment 3
In mass fraction, get following raw material components:
Cortex sophorae 15 parts, Herba Lycopodii 40 parts, Herba Selaginellae 15 parts, Cortex Moutan 10 parts, Herba Taraxaci 10 parts, 10 parts, Poria, Flos Lonicerae 10 parts, Aloe 10 parts.
Its preparation method, comprises the steps:
Step one
Join by the component of design and get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan, Herba Taraxaci, Poria, Flos Lonicerae, Aloe;
Step 2
By join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, first press Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 5 times of Cortex Moutan gross mass, add distilled water, soak after 4 hours, after extracting 3 hours at 98 DEG C, filter, obtain the first filtrate and the first filtering residue, the first filtrate is for subsequent use; First filtering residue proceeds to extract; First filtering residue proceed extraction complete after filtration, obtain the second filtrate and the second filtering residue; Second filtrate is for subsequent use, and the second filtering residue proceeds to extract; Second filtering residue proceeds after extraction completes, to obtain the 3rd filtrate and the 3rd filtering residue; After first filtrate, the second filtrate, the 3rd filtrate mixing, be concentrated into paste in 35 DEG C, obtain mixing creme;
First filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 4 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 98 DEG C, filter;
Second filtering residue proceed the technique extracted for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, 2 times of Cortex Moutan gross mass add after then distilled water extract 1 hour at 98 DEG C, filter;
Step 3
Smashing to pieces joining the Poria got, being placed in mortar and grinding into powder, obtain-200 object Poria fine powders;
Step 4
Clean joining the Flos Lonicerae decontamination got, put in pot, the water content being fried to Flos Lonicerae is less than or equal to 4wt%, takes out after cooling, grinds into powder, obtains-160 object Flos Loniceraes and concocts fine powder, for subsequent use; The temperature of described parch is 180 DEG C;
Step 5
Smash to pieces joining the Aloe of getting, in mass ratio, Aloe: water=3:7, filter after the grinding that adds water, filtrate is Aloe lapping liquid;
Step 6
Being placed in crucible by joining the Herba Taraxaci got, cooling after 300 DEG C of calcining 1h, grinding, obtain-180 object Herba Taraxacis and concoct fine powder,
Step 7
After step 2 gained mixing creme, step 3 gained-200 object Poria fine powder, step 4 gained-160 object Flos Lonicerae are concocted fine powder, step 5 gained Aloe lapping liquid, step 6 gained-180 object Herba Taraxaci process of preparing Chinese medicine fine powder mix homogeneously, after 55 DEG C of dryings, ultraviolet-sterilization, is assembled into capsule.
Animal data:
1. animal hematopoietic function recovery experiment
Healthy ICR mice 80, body weight is 18-22 gram, and male and female half and half are provided by institute of lab animals of Central South University.Animal random packet, blank group, radiation group and compound Chinese medicinal preparation group three groups are established in experiment.
Oral administration gavage administration, 0.2g/, once a day,
Blank group gives distilled water; Radiation group is the medullary thyroid carcinoma cell strain (1 × 106 cell/only) that suspends with 1.0ml normal saline of subcutaneous injection first.The animal of injection tumor cell grows up to the tumor body that can touch after 10 days; Then thyroid carcinoma mice is given 131iodine medicine, compound Chinese medicinal preparation group is the medullary thyroid carcinoma cell strain (1 × 10 that suspends with 1.0ml normal saline of subcutaneous injection first 6cell/only).The animal of injection tumor cell grows up to the tumor body that can touch after 10 days.Then compound Chinese medicinal preparation aqueous solution is given in one hour after giving thyroid carcinoma mice 131 iodine medicine.18th day, take Mouse Weight, get blood in orbital venous plexus, add anticoagulant EDTA.Na, fully automatic blood cytoanalyze measures leukocyte (WBC) and platelet (PLT).Cervical dislocation puts to death white mice, separates both sides femur.Whole medullary cell gone out by the acetic acid of side femur 10ml3% (V/V), and on cytometry dish, count the cell number of four block plaid under ultramicroscope, the number of gained is multiplied by 2.5x10 4, be the bonemarrow nucleated cells number (BMNC) in a femur.Opposite side femur, uses 10mlCaCl 2whole bone marrow pours in centrifuge tube by solution (0.005M), the centrifugal 15min of 2500r/min, abandon supernatant, precipitate is added 5mlHCl solution (0.2mol/L) fully to mix, 90 DEG C of heating 15min, cooling, filters, filtrate measures trap (A) with ultraviolet-uisible spectrophotometer 268nm, represents the content of femur bone marrow DNA.
Table 3
Alone Herba Lycopodii group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex sophorae group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1;
Alone Cortex Moutan group, its extraction process is: water logging is extracted, and the temperature of extraction, time, number of times are completely consistent with embodiment 2; Its consumption is by being taken Herba Lycopodii, Cortex sophorae, Cortex Moutan quality sum in embodiment 1.
In table 3, * represents and to compare with radiation group, and difference has significance therebetween.
Hemopoietic system is the most responsive to radiation, is subject to obvious suppression by the hemopoietic function according to rear mice.The recovery of hemopoietic function is the key factor of prognosis.The change of bone marrow DNA content represents the ability of mouse hemopoietic functional rehabilitation.Compare with blank group, take radioactivity 131the mice of iodine, numeration of leukocyte reduces, and platelet count reduces, and BMNC bonemarrow nucleated cells number increases, and bone marrow DNA content raises.Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number.Show the hemopoietic function can improving mice.Illustrate that Chinese medicine preparation has certain protective effect to radiation damage, also have certain repair to normal cell simultaneously.
Chinese medicine preparation group, to the leukocyte effect of being significantly increased, to platelet (PLT) effect of increasing significantly, reduces bone marrow BMNC cell number.But alone wherein a certain Chinese medicine, it than Chinese traditional compound medicine weak effect, illustrates that Chinese traditional compound medicine has synergism to the protective effect of radiation damage compared with alone a certain Chinese medicine in raising number of white blood cells, platelet (PLT) number effect.
Clinical data:
1, case selection:
Select 131iodine therapy patient 56 example carries out clinical observation, and patient is divided into two groups immediately, protection group 28 example, wherein man 10 example, female 18 example, 25-60 years old ages, 35.3 years old mean age, disease time 1-10 years; Matched group 28 example, wherein man 9 example, women 19 example, 25-60 years old ages, 34.8 years old mean age, the course of disease 1-10 years old; Two groups of patient cases are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, Therapeutic Method:
Patient for protection group applies Chinese medicine preparation of the present invention, oral, each 2, every day 3 times, within 10 days, is a course for the treatment of.
Matched group does not take Chinese medicine preparation of the present invention, follows the doctor's advice and drinks water more.
3, Outcome measure:
Cure: the transference cures such as skin is dark yellow, the damage of nausea and vomiting, hematopoietic cell, high liver fire; In high spirits, health is fully recovered.
Effective: above-mentioned symptom is alleviated to some extent, in high spirits, health is fully recovered.
Invalid: disease is unchanged.
4, therapeutic effect:
Protection group: cure 24 examples, take a turn for the better 2 examples, and invalid 2 examples, cure rate is 85.7%.Total effective rate is 92.8%.
Matched group: cure 10 examples, take a turn for the better 9 examples, and no effect 9, cure rate is 35.7%.Total effective rate is 67.8%.
Above result display, the cure rate of protection group and total effective rate are apparently higher than matched group.
5, model case citing:
1, Ouyang's ××, man, 33 years old, teacher, yiyang, hunan people.Patient comes to seek medical advice because of thyroid papillary carcinoma, applies 131lassitude, appears that skin is dark yellow, in iodine therapy, the subcutaneous easily symptom such as hemorrhage.After taking 3 courses for the treatment of of Chinese medicine preparation of the present invention, transference cure, follows up a case by regular visits to, and symptom is without recurrence.
2, Deng's ××, female, 39 years old, profession, people from Changsha.Patient suffers from thyroid carcinoma, application 131iodine therapy occurs that skin shades, degradation symptom under lassitude, hemogram.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, health is rehabilitation gradually, and symptom is obviously alleviated, and continues to take 2 courses for the treatment of, above transference cure.Follow up a case by regular visits to and do not recur so far.
3, Qin's ××, female, 39 years old, clerk, people from Guangxi.Patient has thyroid carcinoma, application 131there is yellowing of the skin after iodine therapy, play the symptoms such as small pox, lethargy.After taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and after continuing to take 3 courses for the treatment of, above transference cure, physical recovery is healthy, not recurrence.
4, king's ××, female, 44 years old, thyroid carcinoma, application 131there is the symptoms such as skin is dark yellow, high liver fire after iodine therapy, and frequent nausea and vomiting.Recommend through people, take Chinese medicine preparation of the present invention 3 the symptom course for the treatment of and obviously alleviate, after continuing to take 2 courses for the treatment of, transference cure, follows up a case by regular visits to not recurrence.

Claims (9)

1. an alleviation 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Raw materials usedly comprise following component in mass fraction:
Cortex sophorae 10-40 part;
Herba Lycopodii 20-120 part;
Herba Selaginellae 10-40 part;
Cortex Moutan 10-20 part;
Herba Taraxaci 10-20 part;
Poria 10-20 part;
Flos Lonicerae 10-20 part;
Aloe 10-20 part.
2. one according to claim 1 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Raw materials usedly comprise following component in mass fraction:
Cortex sophorae 15-40 part;
Herba Lycopodii 40-120 part;
Herba Selaginellae 15-40 part;
Cortex Moutan 10-20 part;
Herba Taraxaci 10-20 part;
Poria 10-20 part;
Flos Lonicerae 10-20 part;
Aloe 10-20 part.
3. one according to claim 2 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Raw materials usedly comprise following component in mass fraction: Cortex sophorae 40 parts, Herba Lycopodii 120 parts, Herba Selaginellae 40 parts, Cortex Moutan 20 parts, Herba Taraxaci 20 parts, 20 parts, Poria, Flos Lonicerae 20 parts, Aloe 20 parts.
4. one according to claim 2 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Raw materials usedly comprise following component in mass fraction: Cortex sophorae 34 parts, Herba Lycopodii 100 parts, Herba Selaginellae 34 parts, Cortex Moutan 18 parts, Herba Taraxaci 18 parts, 18 parts, Poria, Flos Lonicerae 18 parts, Aloe 18 parts.
5. one according to claim 2 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Raw materials usedly comprise following component in mass fraction:
Cortex sophorae 15 parts, Herba Lycopodii 40 parts, Herba Selaginellae 15 parts, Cortex Moutan 10 parts, Herba Taraxaci 10 parts, 10 parts, Poria, Flos Lonicerae 10 parts, Aloe 10 parts.
6. one according to claim 2 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that; Described Aloe is selected from the one in Aloe vulgaris, Aloe vera L.var. chinensis(Haw.)Berg., upper agricultural university leaf Aloe, Aloe arborescens var. natalensis, aloe ferrox, A.saponaria.
7. the alleviation as described in claim 1-6 any one 131the preparation method of the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that comprising the steps:
Step one
Join by the component of design and get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan, Herba Taraxaci, Poria, Flos Lonicerae, Aloe;
Step 2
By join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean put into container, add water, after extracting at 50-100 DEG C, filter, filtrate is concentrated into paste at 30-60 DEG C, obtain mix creme;
Step 3
Smashing to pieces joining the Poria got, being placed in mortar and grinding into powder, obtain-200 object Poria fine powders;
Step 4
Clean joining the Flos Lonicerae decontamination got, put in pot, the water content being fried to Flos Lonicerae is less than or equal to 5wt%, takes out after cooling, grinds into powder, obtains-160 object Flos Loniceraes and concocts fine powder, for subsequent use; The temperature of described parch is 120-180 DEG C;
Step 5
Smash to pieces joining the Aloe of getting, in mass ratio, Aloe: water=20-80:30-70, filter after the grinding that adds water, filtrate is Aloe lapping liquid;
Step 6
Being placed in crucible by joining the Herba Taraxaci got, cooling after 200-300 DEG C of calcining 0.5-1h, grinding, obtain-180 object Herba Taraxacis and concoct fine powder;
Step 7
After step 2 gained mixing creme, step 3 gained-200 object Poria fine powder, step 4 gained-160 object Flos Lonicerae are concocted fine powder, step 5 gained Aloe lapping liquid, step 6 gained-180 object Herba Taraxaci process of preparing Chinese medicine fine powder mix homogeneously, 40-55 DEG C of drying, obtain compound Chinese medicinal preparation.
8. one according to claim 7 is alleviated 131the preparation method of the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, it is characterized in that: in step 2, by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan decontamination, clean and put into container, first press the 7-9 times of Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan gross mass, add distilled water, soak after 3-4 hour, extract 2-3 hour at 50-100 DEG C, filter, obtain the first filtrate and the first filtering residue, the first filtrate is for subsequent use; First filtering residue proceeds to extract; First filtering residue proceed extraction complete after filtration, obtain the second filtrate and the second filtering residue; Second filtrate is for subsequent use, and the second filtering residue proceeds to extract; Second filtering residue proceeds after extraction completes, to obtain the 3rd filtrate and the 3rd filtering residue; After first filtrate, the second filtrate, the 3rd filtrate mixing, be concentrated into paste in 30-60 DEG C, obtain mixing creme;
First filtering residue proceed extract technique for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan gross mass 4-6 doubly add distilled water then 50-100 DEG C extract 1-2 hour, filter;
Second filtering residue proceed extract technique for: first by join get Cortex sophorae, Herba Lycopodii, Herba Selaginellae, Cortex Moutan gross mass 2-3 doubly add distilled water then 50-100 DEG C extract 1-2 hour, filter.
9. one according to claim 7 is alleviated 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma, is characterized in that: after step 7 gained compound Chinese medicinal preparation carries out ultraviolet sterilization, make the one in capsule, granule, tablet.
CN201510728868.8A 2015-10-30 2015-10-30 A kind of alleviation 131the Chinese medicine preparation of radiation untoward reaction after iodine therapy thyroid carcinoma and preparation method Pending CN105213734A (en)

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