CN105193426B - Non-invasive blood glucose meter - Google Patents
Non-invasive blood glucose meter Download PDFInfo
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- CN105193426B CN105193426B CN201510749831.3A CN201510749831A CN105193426B CN 105193426 B CN105193426 B CN 105193426B CN 201510749831 A CN201510749831 A CN 201510749831A CN 105193426 B CN105193426 B CN 105193426B
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- 239000008280 blood Substances 0.000 title claims abstract description 218
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- 239000008103 glucose Substances 0.000 title claims abstract description 57
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 174
- 102000004877 Insulin Human genes 0.000 claims abstract description 87
- 108090001061 Insulin Proteins 0.000 claims abstract description 87
- 229940125396 insulin Drugs 0.000 claims abstract description 87
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 75
- 239000001301 oxygen Substances 0.000 claims abstract description 75
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 75
- 238000001514 detection method Methods 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 36
- 230000008569 process Effects 0.000 claims abstract description 35
- 238000002347 injection Methods 0.000 claims abstract description 21
- 239000007924 injection Substances 0.000 claims abstract description 21
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- 238000004891 communication Methods 0.000 claims description 44
- 238000004088 simulation Methods 0.000 claims description 39
- 239000007788 liquid Substances 0.000 claims description 19
- 239000000523 sample Substances 0.000 claims description 15
- 210000000496 pancreas Anatomy 0.000 claims description 11
- 238000001802 infusion Methods 0.000 claims description 9
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- 238000006243 chemical reaction Methods 0.000 claims description 5
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- 208000013016 Hypoglycemia Diseases 0.000 description 2
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- 230000002218 hypoglycaemic effect Effects 0.000 description 2
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- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- QJVKUMXDEUEQLH-UHFFFAOYSA-N [B].[Fe].[Nd] Chemical compound [B].[Fe].[Nd] QJVKUMXDEUEQLH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
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- Hematology (AREA)
- Vascular Medicine (AREA)
- High Energy & Nuclear Physics (AREA)
- Anesthesiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The present invention relates to a kind of non-invasive blood glucose meter, described blood glucose meter includes Automatic insulin injection equipment, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP process chip, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment are respectively used to extract blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP processes chip and described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment connect respectively, the blood oxygen supply state of tested personnel is determined based on described blood oxygen saturation data, it is additionally based upon described blood glucose level data and determines the injection parameters of described Automatic insulin injection equipment.Pass through the present invention, on the one hand, can automatically detect the blood oxygen supply situation of tested personnel, on the other hand, it is possible to the self adaptation injection realizing insulin controls.
Description
Technical field
The present invention relates to injection of insulin control field, particularly relate to a kind of non-invasive blood glucose meter.
Background technology
Blood sugar, refers to glucose contained in blood.Postdigestive glucose is entered blood by small intestine,
And each cell being transported in body, it is the main energy sources of cell.The blood sugar of normal person is dense
Spend the most stable, fall within a confirmable blood glucose range.
Blood sugar must keep certain level could maintain each organ internal and the needs of tissue.Blood sugar
Concentration is general to be raised after one to two hours on the feed, and is preferably minimized at breakfast.Blood sugar concentration is lacked of proper care
Can cause multiple disease, hyperglycaemia and too low hypoglycemia that continuation blood sugar concentration is too high all can give people
Health cause serious impact, and the Persistent hyperglycemia caused by many reasons will cause glycosuria
Disease, this is also the most significant disease that blood sugar concentration is relevant.
Prior art exists Medical Instruments of some detection blood sugar, but below these blood glucose meter all exist
Defect: (1) detection pattern is single, can only detect blood sugar concentration；(2) testing mechanism falls behind, knot
Structure redundancy is too high, and precision can not meet the accuracy requirement increasingly increased；(3) there is no blood sugar test
Controlling mechanism with insulin supply, it is impossible to the blood-sugar content self-adaptative adjustment according to tested human body is tested
The supply parameter of the insulin of personnel, such as, feed speed, quantity delivered etc., in addition it is also necessary to manual observation
Blood-sugar content, manual decision's insulin supply parameter, automatization level falls behind；(4) radio communication
Interface is deficient, it is impossible to the parameters relevant to blood sugar is timely fed back to medical server end, even if
There is some simple wireless communication interfaces, such as bluetooth communication interface, its matching mechanisms and connection machine
Inefficiency processed, can not meet the requirement of the high speed transmission data of medical device.
To this end, the present invention proposes a kind of non-invasive blood glucose meter, it is possible to improve the knot of the blood glucose meter fallen behind
Structure, is dissolved into blood oxygen saturation detection in blood glucose meter, widens the scope of the physiological parameter of detection, carry
The precision of hyperglycaemia detection, it is possible to set up the insulin delivery system that blood sugar automatically controls, reduces artificial
Participate in, in addition it is possible to improve existing Bluetooth communication mechanism, improve the speed of Wireless Data Transmission
And efficiency.
Summary of the invention
In order to solve the technical problem that prior art exists, the invention provides a kind of non-invasive blood sugar
Instrument, detects equipment by blood oxygen saturation and blood sugar test equipment concentrates in a detecting instrument work simultaneously
Make, optimize the structure of existing blood sugar test equipment, improve the precision of blood sugar test, add meanwhile
Insulin pump and insulin supply controlling mechanism, it is achieved automatically controlling of blood sugar concentration, particularly important
Be, by improving the matching mechanisms of existing bluetooth communication interface and connection mechanism, improve blood sugar instrument without
The communication performance that line connects.
According to an aspect of the present invention, it is provided that a kind of non-invasive blood glucose meter, described blood glucose meter includes pancreas
At island element automatic injection device, blood oxygen saturation detection equipment, non-invasive blood sugar test equipment and DSP
Reason chip, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment are respectively used to carry
Taking blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP processes chip and described pancreas islet
Element automatic injection device, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment divide
Do not connect, determine the blood oxygen supply state of tested personnel based on described blood oxygen saturation data, be additionally based upon
Described blood glucose level data determines the injection parameters of described Automatic insulin injection equipment.
More specifically, in described non-invasive blood glucose meter, including: Direct Digital Frequency Synthesizers, use
Make being used as mixing as rf frequency source in producing sine wave signal that frequency and phase place can adjust
With；Pulse-series generator, is used for producing pulse train；Frequency mixer, with described Direct Digital frequency
Synthesizer and described pulse-series generator connect respectively, use pulse train to carry out sine wave signal
Mixed modulated；Power amplifier, is connected with described frequency mixer, for being entered by the signal after mixed modulated
Row amplifies；Switching Power Supply, is used as the interface circuit between probe and power amplifier, after amplifying
Signal loading to probe radio-frequency receiving-transmitting coil in；Nd-Fe-B permanent magnetic type magnet structure, tested accommodating
A uniform static magnetic field of field intensity is produced in the space of personnel's finger；Probe, is placed on tested personnel
Finger position, is wound around radio-frequency receiving-transmitting coil and sends into described Nd-Fe-B permanent magnetic type magnet with the signal that will load
In structure, produce nmr phenomena, be additionally operable to after Hydrogen Proton resonance in tested personnel's finger
The deamplification obtained is sent；Light emitting diode, is arranged on tested personnel's finger fingertip capillary position
Put, be connected with light source driving circuit, for the LED control signal sent based on light source driving circuit,
Alternate emission infrared light and ruddiness；Light source driving circuit, built-in timer, for described luminous two
Pole pipe sends LED control signal；Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at
The relative position of described light emitting diode, after being used for receiving transmission tested personnel's finger fingertip capillary
Infrared light and ruddiness, and transmitted infrared light and transmission ruddiness are respectively converted into analog current signal,
To obtain simulation infrared light electric current and simulation ruddiness electric current；Current-to-voltage converting circuit, with described photoelectricity
Converter connects, for simulation infrared light electric current and simulation ruddiness electric current are carried out Current Voltage respectively and turned
Change, to obtain simulation infrared light voltage and simulation red voltages respectively；Signal amplifier, with described electricity
Stream voltage conversion circuit connects, for putting simulation infrared light voltage and simulation red voltages respectively
Greatly, voltage is amplified to obtain to simulate infrared light amplification voltage and simulate ruddiness；Signal deteching circuit, with
Described signal amplifier connects, including direct current signal detection electronic circuit and alternating current signal detection electronic circuit,
For detecting the flip-flop in simulation infrared light voltage and alternating component, using as the first DC voltage
With first alternating voltage output, be additionally operable to detection simulation red voltages in flip-flop with exchange into
Point, to export as the second DC voltage and the second alternating voltage；Analog-digital converter, with described signal
Testing circuit connects, for the first DC voltage, the first alternating voltage, the second DC voltage and the
Two alternating voltages carry out analog-to-digital conversion respectively, to obtain the first Digital DC voltage, the first digitlization
Alternating voltage, the second Digital DC voltage and the second Digital AC voltage；Blood oxygen saturation computing
Circuit, is connected with described analog-digital converter, by the second Digital AC voltage and the second Digital DC
The ratio of voltage divided by the ratio of the first Digital AC voltage and the first Digital DC voltage to obtain
The light ratio factor must be absorbed, and calculate blood oxygen saturation, wherein, blood oxygen based on absorbing the light ratio factor
Saturation degree is linear with the absorption light ratio factor；DSP processes chip, is connected with described probe,
Receive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose institute accounting
Example, thus obtain the blood sugar concentration of tested personnel, described DSP processes chip and also transports with blood oxygen saturation
Calculate circuit to connect to obtain blood oxygen saturation；Described DSP processes chip when described blood sugar concentration is default
During blood sugar upper concentration, send blood sugar concentration too high identification signal, when described blood sugar concentration is at default blood
During sugar least concentration, send blood sugar concentration too low identification signal；When described blood oxygen saturation is at default blood
During oxygen saturation upper concentration, send blood oxygen saturation too high identification signal, when described blood oxygen saturation
When default blood oxygen saturation least concentration, send blood oxygen saturation too low identification signal；Insulin is deposited
Storage equipment, for prestoring the insulin of preset capacity；Liquid level detection device, is positioned at described pancreas islet
In element storage device, the insulin liquid level in detection insulin storage device in real time, and at pancreas islet
When element liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, described liquid level
Detection equipment also processes chip and is connected to send described insufficient insulin alarm signal with described DSP
Chip is processed to described DSP；Insulin drives equipment, processes chip with described DSP and is connected, when
When receiving described blood sugar concentration too high identification signal, process, according to described DSP, the blood sugar that chip forwards
The difference of concentration and described default blood sugar upper concentration determines insulin pump drive signal, described insulin
Pump drive signal determines value and the speed of the supply insulin of insulin pump；Insulin pump, with institute
State insulin storage device and insulin infusion device connects respectively, drive equipment even with described insulin
Connect, under the control driving equipment at described insulin, by the pancreas in described insulin storage device
Island element is expelled in tested personnel's body by insulin infusion device；Insulin infusion device, detachably
Formula is embedded in tested personnel's body, for tested personnel's insulin injection；Serial communication circuit, position
Process between chip and Bluetooth matching communication equipment in DSP, for by described blood sugar concentration and described pancreas
Island element deficiency alarm signal is sent to Bluetooth matching communication equipment；Bluetooth matching communication equipment, being used for will
Described blood sugar concentration and described insufficient insulin alarm signal are wirelessly transmitted to the target Bluetooth connected
Equipment；Described Bluetooth matching communication equipment include the first search subset, second search subset and
Join connexon equipment；Wherein, the first search subset is dense according to MAC Address in Bluetooth Scatternet
Degree determine micro bluetooth network that Bluetooth MAC address concentration is the highest as target piconet, a bluetooth
Scatternet is made up of multiple micro bluetooth networks；Second search subset, with described first search subset
Connect, in described target piconet, find, quantity preceding by signal strength signal intensity ranking and be not more than 7
One or more Bluetooth matching communication equipments as one or more target Bluetooth devices；Equipment connects
Subset, is connected with described second search subset, starts and set with the one or more target Bluetooth
Standby Bluetooth communication connects；Wherein, described optical-electrical converter is a photodiode；Wherein, described
The wavelength of the infrared light that light emitting diode is launched is 940nm, the ruddiness that described light emitting diode is launched
Wavelength is 660nm；Wherein, also set up between described signal amplifier and described signal deteching circuit
Signal filter circuit, amplifies in voltage for filtering simulation infrared light amplification voltage and simulation ruddiness respectively
Noise contribution；Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, spiral pipeline
One in circle, saddle-shaped coils, phased array coils and annulus；Wherein, Direct Digital frequency
The frequency synthesis that synthesizer is used is selected in direct digital synthesizers, analog phase-locked look and digital phase-locked loop
One；Wherein, when the quantity of the Bluetooth matching communication equipment having signal in described target piconet it is
During more than or equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target
Piconet has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more
The quantity of target Bluetooth devices is to have the Bluetooth matching communication equipment of signal in described target piconet
Quantity.
More specifically, in described non-invasive blood glucose meter: the built-in storage that described DSP processes chip is single
It is dense that unit has prestored described default blood oxygen saturation upper concentration, described default blood oxygen saturation lower limit
Degree, described preset reference liquid level, described default blood sugar upper concentration and described default blood sugar least concentration.
More specifically, in described non-invasive blood glucose meter, described blood glucose meter also includes: Compact Flash,
For having prestored described default blood oxygen saturation upper concentration, described default blood oxygen saturation lower limit
Concentration, described preset reference liquid level, described default blood sugar upper concentration and described default blood sugar lower limit are dense
Degree.
More specifically, in described non-invasive blood glucose meter: described DSP processes chip and satisfies sending blood oxygen
Signal, blood oxygen saturation too low identification signal, blood sugar too high identification signal or blood sugar is identified with spending height
During too low identification signal, being simultaneously emitted by abnormality signal, otherwise, described DSP processes chip simultaneously
Send normal state signal.
More specifically, in described non-invasive blood glucose meter: described serial communication circuit is RS485 serial
Communication interface.
Accompanying drawing explanation
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention.
Reference: 1 Automatic insulin injection equipment；2 blood oxygen saturation detection equipment；3 is noninvasive
Formula blood sugar test equipment；4 DSP process chip
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of the non-invasive blood glucose meter of the present invention is described in detail.
Sugar in blood is referred to as blood sugar, is the most all glucose.Internal each histocyte
Energy major part needed for activity is from glucose, so blood sugar preferably must be held in certain level and could tie up
Hold internal each organ and the demand of tissue.
The concentration of the blood sugar in human body is generally controlled in a scope the narrowest, and blood sugar is too high or mistake
Low all can affect to people.In order to effectively detect the blood sugar concentration in human body, on the market
Occur in that multiple blood glucose meter, especially favored by suffering from the patient of hypertension.
But, blood glucose meter of the prior art detection parameter is single, testing mechanism falls behind, and lacks blood sugar
What detection and insulin supplied automatically controls mechanism, and meanwhile, the wireless communication interface being furnished with mates and connects
Connect inefficiency, can not meet the existing requirement of hospital and patient.
To this end, the present invention has built a kind of non-invasive blood glucose meter, high-precision by through structure optimization
Blood oxygen saturation monitoring device and blood glucose monitoring device are integrated in a detecting instrument, use blood simultaneously
Bluetooth communication interface after the sugared automatic control mode detected with insulin supply and optimization, thus square
Just patient and the use of hospital.
Fig. 1 is the block diagram of the first embodiment of the non-invasive blood glucose meter of the present invention, described blood sugar
Instrument includes that Automatic insulin injection equipment, blood oxygen saturation detect equipment, non-invasive blood sugar test equipment
Processing chip with DSP, described blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment divide
Yong Yu not extract blood oxygen saturation data and the blood glucose level data of tested personnel, described DSP process chip with
Described Automatic insulin injection equipment, described blood oxygen saturation detection equipment and the inspection of described non-invasive blood sugar
Measurement equipment connects respectively, determines the blood oxygen supply shape of tested personnel based on described blood oxygen saturation data
State, is additionally based upon described blood glucose level data and determines the injection parameters of described Automatic insulin injection equipment.
Then, continue the concrete structure of the second embodiment of the non-invasive blood glucose meter of the present invention is entered
The explanation of one step.
Described blood glucose meter includes: Direct Digital Frequency Synthesizers, is used for producing frequency and phase place can be adjusted
Whole sine wave signal to be used as mixing use as rf frequency source；Pulse-series generator, is used for
Produce pulse train；Frequency mixer, occurs with described Direct Digital Frequency Synthesizers and described pulse train
Device connects respectively, uses pulse train that sine wave signal is carried out mixed modulated；Power amplifier, with
Described frequency mixer connects, for being amplified by the signal after mixed modulated.
Described blood glucose meter includes: Switching Power Supply, is used as the interface circuit between probe and power amplifier,
Will amplify after signal loading to probe radio-frequency receiving-transmitting coil in；Nd-Fe-B permanent magnetic type magnet structure,
A uniform static magnetic field of field intensity is produced in the space accommodating tested personnel's finger；Probe, places
At tested personnel's finger position, it is wound around radio-frequency receiving-transmitting coil and sends into described neodymium iron boron with the signal that will load
In permanent-magnet type magnet structure, produce nmr phenomena, be additionally operable to hydrogen in tested personnel's finger
The deamplification obtained after proton resonance is sent；Light emitting diode, is arranged on tested personnel's finger fingertip
Capillary position, is connected with light source driving circuit, for the luminescence sent based on light source driving circuit
Control signal, alternate emission infrared light and ruddiness.
Described blood glucose meter includes: light source driving circuit, built-in timer, for described light-emitting diodes
Pipe sends LED control signal；Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at institute
State the relative position of light emitting diode, after receiving transmission tested personnel's finger fingertip capillary
Infrared light and ruddiness, and transmitted infrared light and transmission ruddiness are respectively converted into analog current signal, with
Obtain simulation infrared light electric current and simulation ruddiness electric current；Current-to-voltage converting circuit, turns with described photoelectricity
Parallel operation connects, for simulation infrared light electric current and simulation ruddiness electric current are carried out Current Voltage respectively and turned
Change, to obtain simulation infrared light voltage and simulation red voltages respectively.
Described blood glucose meter includes: signal amplifier, is connected with described current-to-voltage converting circuit, is used for
Simulation infrared light voltage and simulation red voltages are amplified respectively, amplify with acquisition simulation infrared light
Voltage and simulation ruddiness amplify voltage；Signal deteching circuit, is connected with described signal amplifier, including
Direct current signal detection electronic circuit and alternating current signal detection electronic circuit, be used for detecting in simulation infrared light voltage
Flip-flop and alternating component, to export as the first DC voltage and the first alternating voltage, also use
Flip-flop in detection simulation red voltages and alternating component, using as the second DC voltage and the
Two alternating voltage outputs.
Described blood glucose meter includes: analog-digital converter, is connected with described signal deteching circuit, for the
One DC voltage, the first alternating voltage, the second DC voltage and the second alternating voltage carry out modulus respectively
Conversion, to obtain the first Digital DC voltage, the first Digital AC voltage, the second digitlization directly
Stream voltage and the second Digital AC voltage；Blood oxygen saturation computing circuit, with described analog-digital converter
Connect, by the ratio of the second Digital AC voltage and the second Digital DC voltage divided by the first numeral
The ratio changing alternating voltage and the first Digital DC voltage absorbs the light ratio factor to obtain, and based on
Absorbing the light ratio factor and calculate blood oxygen saturation, wherein, blood oxygen saturation becomes with absorbing the light ratio factor
Linear relationship.
Described blood glucose meter includes: DSP processes chip, is connected with described probe, receives described decay letter
Number, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain quilt
The blood sugar concentration of survey personnel, described DSP processes chip and also is connected to obtain with blood oxygen saturation computing circuit
Obtain blood oxygen saturation；Described DSP processes chip when described blood sugar concentration is at default blood sugar upper concentration
Time, send blood sugar concentration too high identification signal, when described blood sugar concentration is at default blood sugar least concentration,
Send blood sugar concentration too low identification signal；When described blood oxygen saturation is dense in the default blood oxygen saturation upper limit
When spending, send blood oxygen saturation too high identification signal, when described blood oxygen saturation is at default blood oxygen saturation
During degree least concentration, send blood oxygen saturation too low identification signal.
Described blood glucose meter includes: insulin storage device, for prestoring the insulin of preset capacity；
Liquid level detection device, is positioned at described insulin storage device, sets for detection insulin storage in real time
Standby interior insulin liquid level, and when insulin liquid level is equal to or less than preset reference liquid level, send pancreas
Island element deficiency alarm signal, described liquid level detection device also processes chip with described DSP and is connected with by institute
State insufficient insulin alarm signal and be sent to described DSP process chip.
Described blood glucose meter includes: insulin drives equipment, processes chip with described DSP and is connected, when connecing
When receiving described blood sugar concentration too high identification signal, the blood sugar processing chip forwarding according to described DSP is dense
The difference of degree and described default blood sugar upper concentration determines insulin pump drive signal, described insulin pump
Drive value and the speed of the supply insulin of signal deciding insulin pump；Insulin pump, with described
Insulin storage device and insulin infusion device connect respectively, drive equipment even with described insulin
Connect, under the control driving equipment at described insulin, by the pancreas in described insulin storage device
Island element is expelled in tested personnel's body by insulin infusion device.
Described blood glucose meter includes: insulin infusion device, detachable is embedded in tested personnel's body,
For to tested personnel's insulin injection.
Described blood glucose meter includes: serial communication circuit, is positioned at DSP and processes chip and Bluetooth matching communication
Between equipment, for described blood sugar concentration and described insufficient insulin alarm signal are sent to bluetooth
Join communication equipment.
Described blood glucose meter includes: Bluetooth matching communication equipment, for by described blood sugar concentration and described pancreas
Island element deficiency alarm signal is wirelessly transmitted to the target Bluetooth devices connected；Described Bluetooth matching communication
Equipment includes the first search subset, the second search subset and coupling connexon equipment；Wherein,
According to MAC Address concentration in Bluetooth Scatternet, one search subset, determines that Bluetooth MAC address is dense
Spending the highest micro bluetooth network as target piconet, a Bluetooth Scatternet is by multiple micro bluetooth networks
Composition；Second search subset, is connected, at described target piconet with described first search subset
In, find, quantity preceding by signal strength signal intensity ranking and be not more than one or more Bluetooth matchings of 7 and lead to
Letter equipment is as one or more target Bluetooth devices；Equipment connexon equipment, with described second search
Subset connects, and starts and is connected with the Bluetooth communication of the one or more target Bluetooth devices；Wherein,
Described optical-electrical converter is a photodiode.
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, described light-emitting diodes
The wavelength of the ruddiness that pipe is launched is 660nm；Wherein, in described signal amplifier and described signal detection
Also set up signal filter circuit between circuit, amplify voltage and simulation for filtering simulation infrared light respectively
Ruddiness amplifies the noise contribution in voltage；Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage
One in coil, toroidal winding, saddle-shaped coils, phased array coils and annulus；Wherein,
Frequency synthesis that Direct Digital Frequency Synthesizers is used select direct digital synthesizers, analog phase-locked look and
One in digital phase-locked loop.
Wherein, when described target piconet having the quantity of Bluetooth matching communication equipment of signal for being more than
During equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target is slight
Net has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more target
The quantity of bluetooth equipment is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
Alternatively, in described blood glucose meter: described DSP processes the built-in storage unit of chip and deposits in advance
Store up described default blood oxygen saturation upper concentration, described default blood oxygen saturation least concentration, described
Preset reference liquid level, described default blood sugar upper concentration and described default blood sugar least concentration；Described blood
Sugar instrument also includes: Compact Flash, be used for having prestored described default blood oxygen saturation upper concentration,
Described default blood oxygen saturation least concentration, described preset reference liquid level, the described default blood sugar upper limit are dense
Degree and described default blood sugar least concentration；Described DSP processes chip and is sending the too high knowledge of blood oxygen saturation
Level signal, blood oxygen saturation too low identification signal, blood sugar too high identification signal or hypoglycemia identification letter
Number time, be simultaneously emitted by abnormality signal, otherwise, described DSP processes chip and is simultaneously emitted by normal shape
State signal；Described serial communication circuit is RS485 serial communication interface.
It addition, dsp chip, also referred to as digital signal processor, it is that one is particularly suitable for carrying out numeral
The microprocessor of signal transacting computing, it is mainly applied is to realize real-time at various data signal
Adjustment method.
According to the requirement of Digital Signal Processing, dsp chip typically has a following main feature: (1)
A multiplication and a sub-addition can be completed within an instruction cycle；(2) program and data space divides
Open, can simultaneously access instruction and data；(3) there is quick RAM in sheet, generally can be by solely
Vertical data/address bus accesses in two pieces simultaneously；(4) there is low overhead or without overhead loop and redirect
Hardware supported；(5) quickly interrupt processing and Hardware I/O support；(6) have in the monocycle
Multiple hardware address generators of interior operation；(7) can be with the multiple operation of executed in parallel；(8) support
Pile line operation, makes fetching, decodes and the operation such as execution can be with Overlapped Execution.
Use the non-invasive blood glucose meter of the present invention, fall behind and nothing for blood sugar apparatus structure in prior art
The technical problem of line communication function difference, optimizes the structure of existing blood sugar instrument, adds the detection of blood oxygen and sets
Standby and blood sugar concentration automatic control equipment, the most also improves the communication performance of existing bluetooth communication interface,
Thus improve the intelligence degree of medical detecting Instrument.
Although it is understood that the present invention discloses as above with preferred embodiment, but above-mentioned enforcement
Example is not limited to the present invention.For any those of ordinary skill in the art, without departing from
Under technical solution of the present invention ambit, all may utilize the technology contents of the disclosure above to the technology of the present invention
Scheme makes many possible variations and modification, or is revised as the Equivalent embodiments of equivalent variations.Therefore,
Every content without departing from technical solution of the present invention, the technical spirit of the foundation present invention is to above example
Any simple modification, equivalent variations and the modification done, all still falls within technical solution of the present invention protection
In the range of.
Claims (1)
1. a non-invasive blood glucose meter, described blood glucose meter includes Automatic insulin injection equipment, blood oxygen
Saturation degree detection equipment, non-invasive blood sugar test equipment and DSP process chip, described blood oxygen saturation
Detection equipment and described non-invasive blood sugar test equipment are respectively used to extract the blood oxygen saturation of tested personnel
Degrees of data and blood glucose level data, described DSP processes chip and described Automatic insulin injection equipment, described
Blood oxygen saturation detection equipment and described non-invasive blood sugar test equipment connect, respectively based on described blood oxygen
Saturation data determines the blood oxygen supply state of tested personnel, is additionally based upon described blood glucose level data and determines described
The injection parameters of Automatic insulin injection equipment；
Described blood glucose meter includes:
Direct Digital Frequency Synthesizers, for produce frequency and sine wave signal that phase place can adjust with
It is used as mixing as rf frequency source to use；
Pulse-series generator, is used for producing pulse train；
Frequency mixer, connects respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator
Connect, use pulse train that sine wave signal is carried out mixed modulated；
Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated；
Switching Power Supply, is used as the interface circuit between probe and power amplifier, the signal after amplifying
It is loaded in the radio-frequency receiving-transmitting coil of probe；
Nd-Fe-B permanent magnetic type magnet structure, produces a field intensity in the space accommodating tested personnel's finger
Uniform static magnetic field；
Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil with the signal that will load
Send in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, be additionally operable to through quilt
The deamplification obtained after Hydrogen Proton resonance in survey personnel's finger is sent；
Light emitting diode, is arranged on tested personnel's finger fingertip capillary position, drives electricity with light source
Road connect, for based on light source driving circuit send LED control signal, alternate emission infrared light and
Ruddiness；
Light source driving circuit, built-in timer, for sending light emitting control letter to described light emitting diode
Number；
Optical-electrical converter, is arranged on tested personnel's finger fingertip, is positioned at the phase of described light emitting diode
To position, it is used for the infrared light after receiving transmission tested personnel's finger fingertip capillary and ruddiness, and
Transmitted infrared light and transmission ruddiness are respectively converted into analog current signal, to obtain simulation infrared electro
Stream and simulation ruddiness electric current；
Current-to-voltage converting circuit, is connected with described optical-electrical converter, for simulation infrared light electric current
Current Voltage conversion is carried out respectively, to obtain simulation infrared light voltage and mould respectively with simulation ruddiness electric current
Intend red voltages；
Signal amplifier, is connected with described current-to-voltage converting circuit, for simulation infrared light voltage
It is amplified respectively with simulation red voltages, amplifies voltage with acquisition simulation infrared light and simulation ruddiness is put
Big voltage；
Signal deteching circuit, is connected with described signal amplifier, including direct current signal detection electronic circuit and
Alternating current signal detection electronic circuit, for detect simulation infrared light voltage in flip-flop with exchange into
Point, to export as the first DC voltage and the first alternating voltage, it is additionally operable to detection simulation red voltages
In flip-flop and alternating component, to export as the second DC voltage and the second alternating voltage；
Analog-digital converter, is connected with described signal deteching circuit, for the first DC voltage, first
Alternating voltage, the second DC voltage and the second alternating voltage carry out analog-to-digital conversion respectively, to obtain first
Digital DC voltage, the first Digital AC voltage, the second Digital DC voltage and the second numeral
Change alternating voltage；
Blood oxygen saturation computing circuit, is connected with described analog-digital converter, by the second Digital AC electricity
Pressure digitizes divided by the first Digital AC voltage and first with the ratio of the second Digital DC voltage
The ratio of DC voltage absorbs the light ratio factor to obtain, and calculates blood oxygen based on absorbing the light ratio factor
Saturation degree, wherein, blood oxygen saturation is linear with the absorption light ratio factor；
DSP processes chip, is connected with described probe, receives described deamplification, analyze described decay
The spectral line of signal, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel,
Described DSP processes chip and also is connected to obtain blood oxygen saturation with blood oxygen saturation computing circuit；Described
DSP process chip, when described blood sugar concentration is at default blood sugar upper concentration, sends blood sugar concentration too high
Identify signal, when described blood sugar concentration is at default blood sugar least concentration, send the too low knowledge of blood sugar concentration
Level signal；When described blood oxygen saturation is at default blood oxygen saturation upper concentration, send blood oxygen saturation
Spend high identification signal, when described blood oxygen saturation is at default blood oxygen saturation least concentration, send
Blood oxygen saturation too low identification signal；
Insulin storage device, for prestoring the insulin of preset capacity；
Liquid level detection device, is positioned at described insulin storage device, deposits for detection insulin in real time
Insulin liquid level in storage equipment, and when insulin liquid level is equal to or less than preset reference liquid level, send out
Go out insufficient insulin alarm signal, described liquid level detection device also with described DSP process chip be connected with
Described insufficient insulin alarm signal is sent to described DSP and processes chip；
Insulin drives equipment, processes chip with described DSP and is connected, when receiving described blood sugar concentration
During too high identification signal, process, according to described DSP, blood sugar concentration and the described default blood sugar that chip forwards
The difference of upper concentration determines insulin pump drive signal, and described insulin pump drives signal deciding pancreas
The value of the supply insulin of island element pump and speed；
Insulin pump, connects respectively with described insulin storage device and insulin infusion device, with institute
Stating insulin drives equipment to connect, under the control driving equipment at described insulin, by described pancreas
Insulin in the element storage device of island is expelled in tested personnel's body by insulin infusion device；
Insulin infusion device, detachable is embedded in tested personnel's body, for noting to tested personnel
Penetrate insulin；
Serial communication circuit, processes between chip and Bluetooth matching communication equipment at DSP, and being used for will
Described blood sugar concentration and described insufficient insulin alarm signal are sent to Bluetooth matching communication equipment；
Bluetooth matching communication equipment, for by described blood sugar concentration and described insufficient insulin alarm signal
It is wirelessly transmitted to the target Bluetooth devices on connecting；Described Bluetooth matching communication equipment includes the first search
Subset, the second search subset and coupling connexon equipment；Wherein, the first search subset, root
Determine that the bluetooth that Bluetooth MAC address concentration is the highest is slight according to MAC Address concentration in Bluetooth Scatternet
Net is as target piconet, and a Bluetooth Scatternet is made up of multiple micro bluetooth networks；Second search
Equipment, is connected with described first search subset, and in described target piconet, it is strong that signal is pressed in searching
Ranking is preceding for degree, quantity be not more than one or more Bluetooth matching communication equipments of 7 as one or
Multiple target Bluetooth devices；Equipment connexon equipment, is connected with described second search subset, starts
It is connected with the Bluetooth communication of the one or more target Bluetooth devices；
Wherein, described optical-electrical converter is a photodiode；
Wherein, the wavelength of the infrared light that described light emitting diode is launched is 940nm, described light-emitting diodes
The wavelength of the ruddiness that pipe is launched is 660nm；
Wherein, between described signal amplifier and described signal deteching circuit, also set up signal filtering electricity
Road, the noise amplified in voltage with simulation ruddiness for filtering simulation infrared light amplification voltage respectively becomes
Point；
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, toroidal winding, saddle
One in coil, phased array coils and annulus；
Wherein, direct digital synthesizers, mould are selected in the frequency synthesis that Direct Digital Frequency Synthesizers is used
Intend the one in phaselocked loop and digital phase-locked loop；
Wherein, when described target piconet having the quantity of Bluetooth matching communication equipment of signal for being more than
During equal to 7, the quantity of the one or more target Bluetooth devices is 7, when described target is slight
Net has signal Bluetooth matching communication equipment quantity for less than 7 time, the one or more target
The quantity of bluetooth equipment is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749831.3A CN105193426B (en) | 2015-11-05 | 2015-11-05 | Non-invasive blood glucose meter |
| CN201680035616.XA CN107949326A (en) | 2015-11-05 | 2016-08-19 | Non-invasive blood glucose meter |
| PCT/CN2016/096038 WO2017076104A1 (en) | 2015-11-05 | 2016-08-19 | Noninvasive blood sugar meter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749831.3A CN105193426B (en) | 2015-11-05 | 2015-11-05 | Non-invasive blood glucose meter |
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| CN105193426A CN105193426A (en) | 2015-12-30 |
| CN105193426B true CN105193426B (en) | 2016-08-17 |
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| CN201510749831.3A Active CN105193426B (en) | 2015-11-05 | 2015-11-05 | Non-invasive blood glucose meter |
| CN201680035616.XA Pending CN107949326A (en) | 2015-11-05 | 2016-08-19 | Non-invasive blood glucose meter |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201680035616.XA Pending CN107949326A (en) | 2015-11-05 | 2016-08-19 | Non-invasive blood glucose meter |
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| WO (1) | WO2017076104A1 (en) |
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| CN105193426B (en) * | 2015-11-05 | 2016-08-17 | 山东大数据医疗科技有限公司 | Non-invasive blood glucose meter |
| CN106037756A (en) * | 2015-11-05 | 2016-10-26 | 张梅 | Noninvasive glucometer |
| CN105549441A (en) * | 2016-01-02 | 2016-05-04 | 无锡桑尼安科技有限公司 | Intelligent electric control system |
| CN207477499U (en) * | 2017-04-21 | 2018-06-12 | 深圳市前海安测信息技术有限公司 | It can the noninvasive intelligent wristwatch for acquiring blood glucose level data |
| CN207477500U (en) * | 2017-04-21 | 2018-06-12 | 深圳市前海安测信息技术有限公司 | The watch of noninvasive acquisition blood glucose level data |
| CN109758164B (en) * | 2017-11-10 | 2024-03-08 | 上海瀚联医疗技术股份有限公司 | Blood glucose monitoring method of blood glucose meter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4875486A (en) * | 1986-09-04 | 1989-10-24 | Advanced Techtronics, Inc. | Instrument and method for non-invasive in vivo testing for body fluid constituents |
| US6723048B2 (en) * | 1999-12-28 | 2004-04-20 | Pindi Products, Inc. | Method and apparatus for non-invasive analysis of blood glucose |
| ATE514440T1 (en) * | 2005-01-17 | 2011-07-15 | Novo Nordisk As | FLUID DISPENSING DEVICE WITH INTEGRATED MONITORING OF PHYSIOLOGICAL PROPERTIES |
| CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
| US20090312622A1 (en) * | 2006-09-28 | 2009-12-17 | Werner Regittnig | Device And Method For Determining A Value Of A Physiological Parameter Of A Body Fluid |
| CN101363841B (en) * | 2007-08-09 | 2013-06-12 | 理康互联科技(北京)有限公司 | Physiology situation information acquisition device |
| CN101138500A (en) * | 2007-08-29 | 2008-03-12 | 中南大学 | Non-invasive blood-sugar detecting instrument based on conservation of energy |
| PT2260423T (en) * | 2008-04-04 | 2018-05-30 | Hygieia Inc | Apparatus for optimizing a patient's insulin dosage regimen |
| AU2012362155A1 (en) * | 2011-12-30 | 2014-01-23 | Abbott Diabetes Care Inc. | Method and apparatus for determining medication dose information |
| CN103622704B (en) * | 2013-12-10 | 2015-07-08 | 中国医学科学院生物医学工程研究所 | Wide-dynamic range pulse blood oxygen measurement system |
| CN104510479A (en) * | 2014-12-12 | 2015-04-15 | 天津大学 | Blood oxygen acquisition system |
| CN106037756A (en) * | 2015-11-05 | 2016-10-26 | 张梅 | Noninvasive glucometer |
| CN105193426B (en) * | 2015-11-05 | 2016-08-17 | 山东大数据医疗科技有限公司 | Non-invasive blood glucose meter |
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2015
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- 2016-08-19 WO PCT/CN2016/096038 patent/WO2017076104A1/en active Application Filing
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| CN105193426A (en) | 2015-12-30 |
| WO2017076104A1 (en) | 2017-05-11 |
| CN107949326A (en) | 2018-04-20 |
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