CN105169552A - Magnetic field stretch type metal-polymer microneedle array manufacturing method - Google Patents
Magnetic field stretch type metal-polymer microneedle array manufacturing method Download PDFInfo
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- CN105169552A CN105169552A CN201510526870.7A CN201510526870A CN105169552A CN 105169552 A CN105169552 A CN 105169552A CN 201510526870 A CN201510526870 A CN 201510526870A CN 105169552 A CN105169552 A CN 105169552A
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- microneedle array
- magnetic field
- matrix
- metal
- micropin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Abstract
The invention relates to the technical field of biomedical engineering and discloses a magnetic field stretch type metal-polymer microneedle array manufacturing method. The method includes: 1) preparing ferromagnetic fluid; 2) allowing spring needles of a microneedle array mould to dip into the ferromagnetic fluid, and putting a matrix in a magnetic field; 3) down pressing the spring needles to enable drops of the ferromagnetic fluid to abut against the matrix under the magnetic force of the magnetic field, and lifting the microneedle array mould to form microneedles with wide bottoms and sharp tops on the matrix; 4) solidifying the microneedles; 5) coating the solidified microneedles with metal layers by sputtering to form a metal-polymer microneedle array. The magnetic field stretch type metal-polymer microneedle array manufacturing method has the advantages of simplicity and convenience in operation, short manufacturing period, high efficiency, reduction of production cost, benefits for popularization of the microneedles and realization of batch production.
Description
Technical field
The present invention relates to the technical field of biomedical engineering method, particularly relate to the manufacture method of the metal-polymer microneedle array that magnetic field stretches.
Background technology
Traditional administering mode mainly contains oral administration, drug administration by injection, sublingual administration, rectally and spraying suction etc., and these administering modes exist more defect respectively, as follows:
Although oral administration is safe and simple, convenient and easy and expense is lower, medicine is easily subject to the impact of other drug and food, and makes the inefficiency of medicine, cannot reach pharmaceutically-active maximization, and some drugs can cause certain infringement to digestive tract; Although drug administration by injection avoids the curative effect shortcoming of oral drugs, can bring more misery to patient, therapeutic effect also can be deteriorated; The administering modes such as sublingual administration, rectally and spraying suction then can only be used for indivedual several drugs, cannot meet the demand of current administration.In addition, also there is problem medicine cannot diluted completely in above-mentioned convenient administration mode.
At present, emerging administering mode mainly contains transdermal administration and micropin administration.Transdermal administration is, by Liniment form, medicine is affixed on skin surface, utilizes the infiltration of skin to carry out medicine transmission, but due to the obstruction of skin, the efficiency of transmission of medicine is low, speed is slow; And micropin administration is as a kind of Wicresoft's means of relative efficiency, had concurrently efficiency high, damage low, can the four large advantages such as slow release, speed is fast, although micropin medicine-feeding technology has plurality of advantages, but, because micropin scaled fine is small, the making being applicable to the micropin of administration is but a difficult problem for medical field, is difficult to process by traditional handicraft.
The making of micropin mainly uses silicon materials, but due to the brashness of silicon materials and the not clear of biocompatibility, the micropin that silicon materials are supported was promoted in current being difficult to.On the contrary, polymer micro needle performance in above is good but be difficult to processing, and relatively, metal-polymer micropin show well in mechanical performance, and well, processed technology maturation, is applicable to the production of micropin to the biocompatibility of some alloys.
In prior art, LIGA technology based on MEMS (MEMS technology) is that the making of metal-polymer microneedle array provides effective way, but, due to synchronous X-ray costly and fabrication cycle long, the cost of LIGA fabrication techniques metal-polymer microneedle array is very high, and complex manufacturing process, wayward, fabrication cycle is long, is not suitable for production.
Summary of the invention
The manufacture method of the metal-polymer microneedle array that the object of the present invention is to provide magnetic field to stretch, is intended to solve in prior art, and the making of metal-polymer microneedle array exists that cost is high, fabrication cycle long and the problem of complex manufacturing process.
The present invention is achieved in that the manufacture method of the metal-polymer microneedle array that magnetic field stretches, and comprises following making step:
1), preparation can solidify to form the ferromagnetic fluids of micropin;
2), utilize the spring needle of microneedle array mould to dip described ferromagnetic fluids, make the lower end of described spring needle be formed with ferromagnetic fluids drop; Described microneedle array mould is placed in magnetic field, and in magnetic field, is placed with matrix ferromagnetic fluids to affinity;
3), described spring needle is placed in above described matrix, press down described spring needle, the ferromagnetic fluids drop of described spring needle lower end is abutted on the matrix, more up carries described microneedle array mould, described ferromagnetic fluids drop forms micropin pointed in bottom width on the matrix;
4), the micropin formed on the matrix is cured;
5) the microneedle surface sputtered metal layer, after described solidification, forms metal-polymer microneedle array.
Compared with prior art, the manufacture method of the metal-polymer microneedle array that magnetic field provided by the invention stretches, by dipping ferromagnetic fluids on the spring needle of microneedle array mould, form ferromagnetic fluids drop in the lower end of spring needle, ferromagnetic fluids drop is connected on matrix, utilizes the magneticaction in magnetic field, ferromagnetic fluids drop forms the micropin of point in bottom width on matrix, after being solidified by micropin, surperficial sputtered metal layer, forms metal-polymer microneedle array; This manufacture method is simple to operation, and fabrication cycle is short, efficiency is high, effectively can reduce production cost, is beneficial to the popularization of micropin, be convenient to realize batch production, economic benefit and social benefit remarkable.
Accompanying drawing explanation
Fig. 1 is the schematic front view of the making step one of the metal-polymer microneedle array of the magnetic field stretching that the embodiment of the present invention provides;
Fig. 2 is the schematic front view of the making step two of the metal-polymer microneedle array of the magnetic field stretching that the embodiment of the present invention provides;
Fig. 3 is the schematic front view of the making step three of the metal-polymer microneedle array of the magnetic field stretching that the embodiment of the present invention provides;
Fig. 4 is the cut-away illustration of the metal-polymer microneedle array of the magnetic field stretching that the embodiment of the present invention provides;
Fig. 5 is the schematic perspective view of the micropin mould of the metal-polymer microneedle array of the magnetic field stretching that stupid inventive embodiments provides.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Below in conjunction with specific embodiment, realization of the present invention is described in detail.
The corresponding same or analogous parts of same or analogous label in the accompanying drawing of the embodiment of the present invention, in describing the invention, it will be appreciated that, if have term " on ", D score, " left side ", orientation or the position relationship of the instruction such as " right side " are based on orientation shown in the drawings or position relationship, only the present invention for convenience of description and simplified characterization, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore the term of position relationship is described only for exemplary illustration in accompanying drawing, the restriction to this patent can not be interpreted as, for the ordinary skill in the art, the concrete meaning of above-mentioned term can be understood as the case may be.
With reference to shown in Fig. 1 ~ 5, it is preferred embodiment provided by the invention.
The manufacture method of the metal-polymer microneedle array that the magnetic field that the present embodiment provides stretches comprises the following steps:
1), for the preparation of the ferromagnetic fluids forming micropin 14, this ferromagnetic fluids can solidify solidification;
2) spring needle 121 of microneedle array mould 12, is utilized to dip ferromagnetic fluids, spring needle 121 lower end is made to be formed with ferromagnetic fluids drop 13, and microneedle array mould 12 is placed in magnetic field, in magnetic field, be placed with matrix 11, this matrix 11 pairs of ferromagnetic fluids have affinity or attractability;
3), the spring needle 121 of microneedle array mould 12 is placed in above matrix 11, press down spring needle 121, the ferromagnetic fluids drop 13 of spring needle 121 lower end is made to be connected to matrix 11, up mention mould 12 again, under the influence of a magnetic field, ferromagnetic fluids drop 13 forms needle-like on matrix 11, namely sharp in bottom width shape, forms micropin 14;
4) and be cured the micropin 14 be formed on matrix 11, multiple micropin 14 forms the microneedle array be positioned on matrix 11;
5) sputter layer of metal layer on the surface of the micropin 14, on matrix 11, makes microneedle array form metal-polymer microneedle array.
In the manufacture method of the above-mentioned metal-polymer microneedle array provided, by dipping ferromagnetic fluids on the spring needle 121 of microneedle array mould 12, ferromagnetic fluids drop 13 is formed in the lower end of spring needle 121, ferromagnetic fluids drop 13 is connected on matrix 11, utilize the magneticaction in magnetic field, ferromagnetic fluids drop 13 forms the micropin 14 of point in bottom width on matrix 11, after being solidified by micropin 14, surface sputtered metal layer, forms metal-polymer microneedle array; This manufacture method is simple to operation, and fabrication cycle is short, efficiency is high, effectively can reduce production cost, is beneficial to the popularization of micropin 14, be convenient to realize batch production, economic benefit and social benefit remarkable.
In the present embodiment, in step 4) and 5) between, after the micropin 14 on matrix 11 solidifies, matrix 11 is smeared PDMS solution, to make matrix 11 obtain good substrate mechanical property and surface property, be also convenient to sputtered metal layer, and, at the plated surface last layer metal of micropin 14, conveniently on micropin 14, dip medicine carries out administration.
Or, as other embodiments, matrix 11 is formed with the flexible substrates that PDMS solution is formed, like this, the ferromagnetic fluids drop 13 on the spring needle 121 of microneedle array mould 12 directly abuts on a flexible substrate, after micropin 14 solidifies, microneedle array then can directly and flexible substrates respectively, thus without the need to repasting upper PDMS solution, then can between vacuum in sputtered metal layer, form metal-polymer microneedle array.
Particularly, matrix 11 generally adopts filter paper, certainly, also can adopt other materials, thus stretching ferromagnetic fluids drop 13 on the surface being convenient to the matrix 11 of spring needle 121, form micropin 14, manufacture the metal-polymer microneedle array being applicable to different field.
In addition, when spring needle 121 is at stretching ferromagnetic fluids drop 13, during in order to avoid stretching, matrix 11 is difficult to fix, bottom glass sheet is provided with in the below of matrix 11, and the both sides above matrix 11 are respectively equipped with pressed glass sheet, utilize pressed glass sheet to press against matrix 11, thus the stretching of ferromagnetic fluids drop 13 in magnetic field is carried out smoothly.
In the present embodiment, by when micropin 14 is cured on the matrix 11 of formation, adopts the method for heating to be heating and curing, heating film is set in the below of bottom glass, utilize heating film by the heat conduction of bottom glass, the micropin 14 on the matrix 11 formed is heating and curing.Further, in order to better control the heating-up temperature of heating film, between heating film and electromotor, being connected with controller, utilizing the heating of controller to heating film to control.Particularly, heating film can adopt PI heating film.
As other embodiments, the heat distributed after can adopting coil electricity heats the micropin 14 on matrix 11.
Generally, to the temperature that micropin 14 is heating and curing, controller is utilized to control below 80 DEG C; Or when adopting other conditions of cure, light (as infrared light) also can be adopted to be cured micropin 14, and after 1-2 hour, micropin 14 has solidified, and obtains microneedle array.
In the present embodiment, the coil of energising is utilized to produce magnetic field, and, in order to shorten the fabrication cycle of metal-polymer microneedle array, increasing magnetic field, multiple coil can be stacked together, form the magnetic field that intensity is larger.
Particularly, utilize in doorframe shape and the metal rack of alterable height, place coil, after this coil electricity, then form magnetic field in the below of metal rack, above-mentioned matrix 11 and 12, the mould dipping ferromagnetic fluids drop 13 are placed in the magnetic field that coil produces.
Particularly, matrix 11 is arranged in magnetic field, in order to ensure the maximization of magnetic field intensity, matrix 11 is placed on the center of coil, and, comparatively even in order to ensure the structure of the micropin 14 stretched, the amount of the ferromagnetic fluids drop 13 that each spring needle 121 of microneedle array mould 12 dips is roughly equal.
In the present embodiment, the structure of microneedle array mould 12 is as follows: sequentially put stacking with multiple Magnet, form multilamellar platform, each Magnet is placed with the copper sheet of band pin hole, the upper end of spring needle 121 is plugged in the pin hole of copper sheet, and makes the syringe needle of multiple spring needle 121 lower end be in same plane layout.
Particularly, generally, adopt 2 ~ 3 layers of Magnet to set for this platform, copper sheet placed by the platform that each Magnet is formed.
In above-mentioned steps 4) in, after spring needle 121 dips ferromagnetic fluids drop 13, after ferromagnetic fluids drop 13 stretches and forms micropin 14 on matrix 11, need the syringe needle bubble of the spring needle 121 by dipping ferromagnetic fluids drop 13 in ethanol, when the ferric remains magnetic fluid on spring needle 121 syringe needle is dissolved in ethanol, wiped clean and air-dry after, spring needle 121 could continue use.
In the present embodiment, stretchable ferromagnetic fluids includes micron order or nano-scale particle and macromolecular material, and according to performance requirement, according to suitable ratio, micron order or nano-scale particle are mixed with macromolecular material, preferably both mixed proportions are 1:1; Further, as preferred embodiment, macromolecular material is epoxy resin.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the manufacture method of the metal-polymer microneedle array of magnetic field stretching, is characterized in that, comprise following making step:
1), preparation can solidify to form the ferromagnetic fluids of micropin;
2), utilize the spring needle of microneedle array mould to dip described ferromagnetic fluids, make the lower end of described spring needle be formed with ferromagnetic fluids drop; Described microneedle array mould is placed in magnetic field, and in magnetic field, is placed with matrix ferromagnetic fluids to affinity;
3), described spring needle is placed in above described matrix, press down described spring needle, the ferromagnetic fluids drop of described spring needle lower end is abutted on the matrix, more up carries described microneedle array mould, described ferromagnetic fluids drop forms micropin pointed in bottom width on the matrix;
4), the micropin formed on the matrix is cured;
5) the microneedle surface sputtered metal layer, after described solidification, forms metal-polymer microneedle array.
2. the manufacture method of the metal-polymer microneedle array of magnetic field as claimed in claim 1 stretching, is characterized in that, in described step 4) and step 5) between, when after the micropin solidification on described matrix, smear PDMS solution on the matrix.
3. the manufacture method of the metal-polymer microneedle array of magnetic field as claimed in claim 1 stretching, is characterized in that, is placed on the flexible substrates matrix in described magnetic field being formed with the formation of PDMS solution.
4. the manufacture method of the metal-polymer microneedle array that the magnetic field as described in any one of claims 1 to 3 stretches, it is characterized in that, in described step 3) in, the below of described matrix is provided with bottom glass sheet, and the both sides of side are respectively equipped with pressed glass sheet on the matrix.
5. the manufacture method of metal-polymer microneedle array that stretches of magnetic field as claimed in claim 4, is characterized in that, in described step 4) in, heating film is set at described bottom glass sheet, is heating and curing the micropin on described matrix by described heating film.
6. the manufacture method of the metal-polymer microneedle array of magnetic field as claimed in claim 5 stretching, is characterized in that, be provided with controller between described heating film and electromotor, utilizes described controller to control the heating-up temperature of heating film.
7. the manufacture method of the metal-polymer microneedle array that the magnetic field as described in any one of claims 1 to 3 stretches, it is characterized in that, in described step 4) in, after adopting coil electricity, the micropin on described matrix is heating and curing, and controls heating-up temperature below 80 DEG C.
8. the manufacture method of the metal-polymer microneedle array that the magnetic field as described in any one of claims 1 to 3 stretches, it is characterized in that, adopt the metal rack of alterable height, coil is placed below described family members' valency, form magnetic field after described coil electricity, described matrix is placed on the center of described coil.
9. the manufacture method of the metal-polymer microneedle array that the magnetic field as described in any one of claims 1 to 3 stretches, it is characterized in that, described microneedle array grinding tool comprises multiple sequentially to stacking the Magnet put, Magnet described in each is provided with the copper sheet of band pin hole, the upper end of described spring needle is plugged in the pin hole of described copper sheet, and the syringe needle of described spring needle lower end is in same plane position.
10. the manufacture method of the metal-polymer microneedle array that the magnetic field as described in any one of claims 1 to 3 stretches, it is characterized in that, described ferromagnetic fluids comprises micron order or nano-scale particle and macromolecular material, and the mixed proportion of described micron order or nano-scale particle and described macromolecular material is 1:1.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106063970A (en) * | 2016-05-24 | 2016-11-02 | 华中科技大学 | A kind of hyaluronic acid microneedle array carrying gold nanometer cage and preparation and application thereof |
CN108553751A (en) * | 2018-04-20 | 2018-09-21 | 威海迈尼生物科技有限公司 | A kind of hyaluronic acid micropin and preparation method thereof of load magnetic ball pharmaceutical carrier |
EP3345649A4 (en) * | 2016-05-20 | 2019-03-27 | Raphas Co., Ltd. | Method for manufacturing microneedle |
CN113520986A (en) * | 2021-06-16 | 2021-10-22 | 暨南大学 | Random curved surface polymer microneedle array and preparation method thereof |
CN114393764A (en) * | 2022-01-14 | 2022-04-26 | 南京工业大学 | Method for manufacturing superfine microneedle patch based on biaxial stretching technology |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010131123A (en) * | 2008-12-03 | 2010-06-17 | Medorekkusu:Kk | Method of carrying medicament to microneedle array |
CN103908740A (en) * | 2014-03-05 | 2014-07-09 | 中山大学 | Metal microneedle array manufacturing method |
CN103908739A (en) * | 2014-03-05 | 2014-07-09 | 中山大学 | Method for manufacturing metal microneedle array |
CN104307097A (en) * | 2014-10-28 | 2015-01-28 | 中山大学 | Method for manufacturing flexible-substrate metal microneedle array |
CN104707240A (en) * | 2015-03-06 | 2015-06-17 | 中山大学 | Method for manufacturing magnetic guiding nanometer connection porous microneedle array |
-
2015
- 2015-08-25 CN CN201510526870.7A patent/CN105169552B/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010131123A (en) * | 2008-12-03 | 2010-06-17 | Medorekkusu:Kk | Method of carrying medicament to microneedle array |
CN103908740A (en) * | 2014-03-05 | 2014-07-09 | 中山大学 | Metal microneedle array manufacturing method |
CN103908739A (en) * | 2014-03-05 | 2014-07-09 | 中山大学 | Method for manufacturing metal microneedle array |
CN104307097A (en) * | 2014-10-28 | 2015-01-28 | 中山大学 | Method for manufacturing flexible-substrate metal microneedle array |
CN104707240A (en) * | 2015-03-06 | 2015-06-17 | 中山大学 | Method for manufacturing magnetic guiding nanometer connection porous microneedle array |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3345649A4 (en) * | 2016-05-20 | 2019-03-27 | Raphas Co., Ltd. | Method for manufacturing microneedle |
CN106063970A (en) * | 2016-05-24 | 2016-11-02 | 华中科技大学 | A kind of hyaluronic acid microneedle array carrying gold nanometer cage and preparation and application thereof |
CN106063970B (en) * | 2016-05-24 | 2019-03-05 | 华中科技大学 | It is a kind of carry gold nanometer cage hyaluronic acid microneedle array and its preparation and application |
CN108553751A (en) * | 2018-04-20 | 2018-09-21 | 威海迈尼生物科技有限公司 | A kind of hyaluronic acid micropin and preparation method thereof of load magnetic ball pharmaceutical carrier |
CN113520986A (en) * | 2021-06-16 | 2021-10-22 | 暨南大学 | Random curved surface polymer microneedle array and preparation method thereof |
CN114393764A (en) * | 2022-01-14 | 2022-04-26 | 南京工业大学 | Method for manufacturing superfine microneedle patch based on biaxial stretching technology |
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