CN105148021A - Preparation for treating cerebral infarction and preparation method thereof - Google Patents

Preparation for treating cerebral infarction and preparation method thereof Download PDF

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CN105148021A
CN105148021A CN201510635245.6A CN201510635245A CN105148021A CN 105148021 A CN105148021 A CN 105148021A CN 201510635245 A CN201510635245 A CN 201510635245A CN 105148021 A CN105148021 A CN 105148021A
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herba
flos
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lupuli
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Abstract

The invention discloses a preparation for treating cerebral infarction and a preparation method thereof. The preparation is mainly prepared from, by weight, 8-14 parts of acorus tatarinowii, 9-13 parts of edible palm, 11-16 parts of buckbean, 10-14 parts of perilla leaf, 7-13 parts of toothed habenaria root, 8-12 parts of bile arisaema, 6-14 parts of sri lanka pouzolzia herb, 7-15 parts of verbenaceae stachytarpheta jamaicensis, 9-14 parts of franchet peashrub flower, 8-15 parts of involute spikemoss herb, 10-16 parts of cistanche salsa, 7-14 parts of lycopodium obscurum, 6-10 parts of bombyx batryticatus and 9-15 parts of hop. The preparation is fine prepared from frequently-seen traditional Chinese medicines, has effects on activating blood circulation and restoring mental clarity, clearing and activating the channels and collaterals, nourishing and suppressing yang, and calming liver wind, can improve the blood supply and oxygen supply amount of brain tissue and recover cranial nerve system functions, and has a remarkable effect on treating cerebral infarction.

Description

For curing preparation and the method for making of cerebral infarction
Technical field
The invention belongs to traditional Chinese medicine field, especially relating to a kind of preparation for curing cerebral infarction and method for making.
Background technology
Cerebral infarction is due to cerebral atherosclerosis, blood vessel internal membrane damage makes cerebral arteries luminal stenosis, and then local thrombus is formed because of many factors, stricture of artery is increased the weight of or entirely shuts, cause brain tissue ischemia, anoxia, necrosis, cause a kind of cerebrovascular of delayed ischemic neurological deficits.The cerebrovascular disease such as cerebral infarction, cerebral thrombosis is the third-largest disease of harm humans health, the disease that Ye Shi China disability rate is the highest.Due to the progress of medical diagnosis and treatment technology, patients with cerebral apoplexy salvage success rate improves constantly, and heavier patient is given treatment to successfully many state of an illness, but all leaves the deformity of varying degree.At the cerebral apoplexy patient treatment initial stage, a lot of patients with stroke with the sequela such as hemiplegia, aphasia, dysphagia and shoulder-hand syndrome.Most of patients Consciousness after cerebral infarction morbidity, minority can have the disturbance of consciousness that degree is different, and general vital sign is without obvious change.If cerebral hemisphere larger area infarction, ischemia, edema, can affect the function of diencephalon and brain stem, rise and occur disturbance of consciousness soon after being ill, even cerebral hernia, death.If namely unclear consciously after morbidity, Vertebro-basilar System cerebral infarction be considered.Cerebral infarction can repeatedly be sent out again.Once suffer from cerebral infarction, illustrate that body has possessed thrombosed three class foundation factors, the factor such as damage, the change of blood matter, hemodynamic change of blood vessel endothelium, these factors, as can not get effective control, will be sent out repeatedly again.
In general, more or less all there is hardening phenomenon in the blood vessel of old people, and this is the physiological phenomenon determined by age factor.Especially after the sleep at a night, the moisture in body consumes to some extent, and can not supplement in time, causes haemoconcentration to increase, and this phenomenon old people is particularly evident.In recent years, China medical expert had carried out the investigation of disease time aspect once by 2,000 many cases cerebral embolism patients, result shows: 4:00 AM to 8 is the onset peak time of cerebral embolism.The patient that wherein falls ill in 4 o'clock to 6 o'clock accounts for all patients 1/3, is the first rush hour of morbidity; Be the second rush hour that cerebral embolism is fallen ill in the morning 6 o'clock to 8 o'clock, and in this time, the patient of morbidity accounts for 1/4th of all patients.
The method of existing Chinese traditional treatment cerebral infarction is more, publication number CN104127515A(application number 201410399569.X) patent discloses a kind of composition and method of making the same for the treatment of cerebral thrombotic infarction, described compositions is made up of the component of following weight parts: Chinese fanpalm seed 8-18 part; Radix Semiaquilegiae 9-12 part; Fructus Phyllanthi 9-25 part; Radix Ranunculi Ternati 6-10 part; Holotrichia diomphalia Bates 6-15 part; Bombyx Batryticatus 9-25 part; Scorpio 6-9 part; Radix Astragali 15-35 part, Radix Cynanchi Auriculati 20-35 part.Publication number CN102716212A(application number 201210206028.1) patent discloses a kind of medicine for the treatment of cerebral infarction, described medicine is divided into oral medicine and outer washing medicine, and wherein oral medicine is the medicament be made up of the crude drug of following weight parts: Ramulus Cinnamomi 8-20 part, Herba Pileae Scriptae 15-50 part, Radix Salviae Miltiorrhizae 15-50 part, Herba Leonuri 10-28 part, Folium Perillae 10-28 part, Radix Clematidis 5-28 part, Radix Acanthopanacis Trifoliati 10-30 part, Herba Taxilli 10-30 part, Caulis Kadsurae Coccineae 10-28 part, extra large maple rattan 10-28 part, Radix Achyranthis Bidentatae 10-48 part, Semen Euryales 10-28 part, Rhizoma Cibotii 20-38 part; Outer washing medicine is made up of the medical herbs of following weight parts: Fructus Litseae tree 100-200 part, bigcatkin willow Prunus mume (Sieb.) Sieb. Et Zucc 100-200 part, Herba Cymbopogonis Citrari 100-200 part.Publication number CN104524278A(application number 201410791331.1) patent discloses a kind of Chinese medicine composition for the treatment of cerebral infarction, according to weight parts, composed of the following components: Yunnan five tastes 12-30 part, wild Pedicellus et Pericarpium Trapae root 15-25 part, Poria 10-20 part, Herba Scutellariae Barbatae 10-20 part, Radix Et Caulis Acanthopanacis Senticosi 10-20 part, Cortex Meliosmatis rigidae Radicis 10-20 part, Pheretima 10-20 part, Lagochuilus platyacanthus Rupr. 10-20 part, Radix Astragali Preparata 10-20 part, Radix Salviae Miltiorrhizae 5-12 part, Fructus Hippophae 5-12 part, Folium Ilicis 5-12 part, Caulis Zizaniae caduciflorae 5-12 part, Rhizoma Acori Graminei 5-12 part, Plumula Nelumbinis 5-20 part, Herba Arthraxonis Hispidi 10-20 part, Fructus Citri Sarcodactylis 10-20 part, Radix Glochidionis eriocarpi 10-20 part, Thunbergia fragrans Roxb. 20-30 part, HERBA ANDROGRAPHITID 10-20 part.
At present, although western medicine cerebral infarction is rapid-action, therapy target is single, be difficult to accomplish to treat from blood and blood vessel simultaneously, and most Western medicine, comprise aspirin, capital produces drug resistance in various degree, and the side effect of most Western medicine is obvious, is not suitable for long-term taking.And the effect of some current Chinese medicines is indefinite, curative effect is not remarkable.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the preparation for curing cerebral infarction, adopt common Chinese medicine material to refine to form, there is effect of opening the orifice and activating blood circulation, dredge the meridian passage, nourishing YIN for suppressing the hyperactive YANG, suppressing the hyperactive liver to relieve the wind syndrome, cerebral tissue blood supply oxygen-supplying amount can be improved, recover cerebral nervous system function, treatment cerebral infarction is evident in efficacy.Another object of the present invention is to provide the preparation method of the above-mentioned preparation for curing cerebral infarction.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
For curing the preparation of cerebral infarction, taking off the primary raw material stating weight proportion and being prepared from: Rhizoma Acori Graminei 8-14 part; Fructus Phoenicis Dactyliferae 9-13 part; Herba menyanthis 11-16 part; Folium Perillae 10-14 part; Radix Habenariae Dentatae 7-13 part; Arisaema Cum Bile 8-12 part; Herba Pouzolziae Zeylanicae 6-14 part; Herba Stachytarphetae Jamaicensis 7-15 part; Flos Caraganae Franchetianae 9-14 part; Herba Selaginellae Involventis 8-15 part; Herba Cistanches 10-16 part; Herba Lycopodii Obscuri 7-14 part; Bombyx Batryticatus 6-10 part; Flos lupuli (Flos Humuli Lupuli) 9-15 part.
For curing the preparation of cerebral infarction, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Acori Graminei 10-12 part; Fructus Phoenicis Dactyliferae 10-12 part; Herba menyanthis 13-15 part; Folium Perillae 11-13 part; Radix Habenariae Dentatae 9-11 part; Arisaema Cum Bile 9-11 part; Herba Pouzolziae Zeylanicae 9-11 part; Herba Stachytarphetae Jamaicensis 10-12 part; Flos Caraganae Franchetianae 11-13 part; Herba Selaginellae Involventis 11-13 part; Herba Cistanches 12-14 part; Herba Lycopodii Obscuri 10-12 part; Bombyx Batryticatus 7-9 part; Flos lupuli (Flos Humuli Lupuli) 11-13 part.
For curing the preparation of cerebral infarction, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Acori Graminei 11 parts; Fructus Phoenicis Dactyliferae 11 parts; Herba menyanthis 14 parts; Folium Perillae 12 parts; Radix Habenariae Dentatae 10 parts; Arisaema Cum Bile 10 parts; Herba Pouzolziae Zeylanicae 10 parts; Herba Stachytarphetae Jamaicensis 11 parts; Flos Caraganae Franchetianae 12 parts; Herba Selaginellae Involventis 12 parts; Herba Cistanches 13 parts; Herba Lycopodii Obscuri 11 parts; Bombyx Batryticatus 8 parts; Flos lupuli (Flos Humuli Lupuli) 12 parts.
Present invention also offers the preparation method above-mentioned preparation for curing cerebral infarction being made pharmaceutically acceptable decoction, granule, concentrated pill, Tablet and Capsula.
The preparation method of the described preparation decoction for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine, moistening 8-10 hour, take out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, sterile packaged.
According to preparation method recited above, the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass, and the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass.
Instructions of taking: each 100-150ml, every day 2 times, 8 days courses for the treatment of.
The preparation method of the described preparation granules agent for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
According to preparation method recited above, step (4) is preferably concentrated into the thick paste of relative density 1.13-1.17, is more preferably the thick paste being concentrated into relative density 1.15.
Instructions of taking: each 1 bag, takes after melting, every day 2 times, 8 days courses for the treatment of by warm water.
The preparation method of the described preparation concentrated pill for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), (preferred diameter is 3-5mm to make concentrated pill, being more preferably diameter is 4mm), sterile packaged.
Using method: each 6-10 ball, with warm water delivery service, every day 2 times, 8 days courses for the treatment of.
The preparation method of the described formulation tablet for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make tablet.
Instructions of taking: each 2-3 sheet, every day 2 times, 8 days courses for the treatment of.
The preparation method of the described preparation capsule for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.20-1.30(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.23-1.27, be more preferably the thick paste being concentrated into relative density 1.25), dry, pulverize, cross 180-200 mesh sieve, make capsule (preferred 0.4-0.6g/ grain, is more preferably 0.5g/ grain).
Instructions of taking: each 2-3 grain, every day 2 times, 8 days courses for the treatment of.
The pharmacological effect of each crude drug is respectively:
Rhizoma Acori Graminei: another name Rhizoma Acori Graminei, prosperous grass, spring snow, water Rhizoma Acori Graminei etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.For the dry rhizome of acorus gramineus araceae plant.There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.
Fructus Phoenicis Dactyliferae: sweet in the mouth, warm in nature.Return spleen, lung meridian.For the fruit of babassu nipa palm.Containing protein, fat, polysaccharide, glucose, fructose, sucrose, aminoacid, flavone sulfuric acid ester, also containing organic acid, in addition, carotenoid is also had, the pigments such as anthocyanidin, vitamin A, C etc.Another containing oligo-element potassium, sodium, calcium, phosphorus, ferrum, copper, zinc, magnesium and multiple enzyme.There is QI invigorating tonify deficiency, the effect of the expectorant that helps digestion.Frail for the deficiency of vital energy, accumulation of food in the stomach and intes tine due to indigestion, brings up phlegm when one coughs.
Herba menyanthis: sweet in the mouth, micro-hardship, cold in nature.GUIXIN, spleen channel.For herb or the leaf of gentianaceae plant Herba menyanthis.Containing trifolin, globulariacitrin, hyperin, foliamenthin, Semen Strychni glycoside, menthiafolin, dihydrofoliamenthin, disconnected Semen Strychni glycoside, sweroside, scopoletin, caffeic acid, ferulic acid.There is strengthening the spleen to promote digestion, tranquilizing by nourishing the heart, effect of clearing away heat and promoting diuresis.For gastritis, dyspepsia, palpitation and insomnia, jaundice due to damp-heat, cholecystitis, edema, dysuria, fervid puckery pain.
Folium Perillae: acrid in the mouth, warm in nature.Return lung, spleen channel.For dried leaves or the band twig of labiate Folium Perillae.There is the cold expelling that induces sweat, effect of relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
Radix Habenariae Dentatae: sweet in the mouth, hardship, property is put down.Return lung, kidney channel.For the tuber of the beautiful phoenix flower of orchid Pluma Anseris domestica.There is the kidney invigorating lung benefiting, dampness removing, effect of removing toxic substances.For lumbago due to renal deficiency, sexual impotence, pulmonary tuberculosis cough, edema, leukorrhagia, hernia, carbuncle furunculosis, snake bite and insect sting.
Arisaema Cum Bile: bitter in the mouth, micro-pungent, cool in nature.Return lung, liver, spleen channel.For the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or form through fermentation processing for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.There is removing heat-phlegm, effect of dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Herba Pouzolziae Zeylanicae: sweet in the mouth, light, cold in nature.For herb or the whole herb with root of contrayerva Herba Pouzolziae Zeylanicae.There is heat-clearing and toxic substances removing, spleen invigorating, effect of hemostasis.For skin ulcer, carbuncle, scrofula, dysentery, women leucorrhea, infantile malnutrition, spits blood, traumatic hemorrhage.
Herba Stachytarphetae Jamaicensis: sweet in the mouth, micro-hardship, cold in nature.GUIXIN, liver, kidney channel.For herb and the root of the false horsewhip of Verbenaceae.Containing n-nonacosane, n-melissane, the higher alkanes such as n-pentatriacontane, hitodesterol, saturated fat ketone, aliphatic saturated monocarboxylic acid and unsaturated hydroxy carboxylic acid.There is clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling.For pyretic stranguria, stranguria caused by urinary stone, nebulousurine, leucorrhea, rheumatic ostalgia, acute conjunctivitis, pharyngolaryngitis, gingivitis, cholecystitis, carbuncle furuncle, hemorrhoid, treating swelling and pain by traumatic injury.
Flos Caraganae Franchetianae: sweet in the mouth, micro-hardship, property is put down.Return kidney channel.For the flower of leguminous plant Yunnan caragana.There is effect of QI invigorating kidney tonifying.For tinnitus due to deficiency of the kidney, dizziness and blurred vision, headache, pulmonary tuberculosis cough, infantile malnutrition.
Herba Selaginellae Involventis: lightly seasoned, micro-hardship, cool in nature.Return lung, liver, the heart, spleen channel.For the herb of Spikemoss plant Herba Selaginellae Involventis.Containing trehalose, potassium, magnesium, calcium, ferrum, sodium, manganese, zinc, copper.There is clearing away heat-damp and promoting diuresis, cough-relieving, hemostasis, effect of removing toxic substances.For jaundice due to damp-heat, dysentery, edema, ascites, stranguria, productive cough due to phlegm-damp, spitting of blood, spits blood, has blood in stool, metrorrhagia, traumatic hemorrhage, acute mastitis, scrofula, hemorrhoid, scalds.
Herba Cistanches: sweet in the mouth, salty, warm in nature.Return kidney, large intestine channel.The fleshy stem of the dry zone scale leaf of Rong is sent out for orobanchaceae plant cistanche or pipe fat and red meat.There is kidney-replenishing, benefiting essence-blood, effect of loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.
Herba Lycopodii Obscuri: sour in the mouth, warm in nature.Return lung, kidney channel.For the herb of lycopsid Herba Lycopodii Obscuri Lycopodium clavatum.Containing alkaloid: α-obscurine, β-obscurine, the peaceful alkali of Herba Lycopodii Obscuri, lycopodine, [4aR-(4a.alpha.,5.alpha.,10b.alpha.,12R .), rod lycoclavanin alkali, dihydro lycopodine, fan lycopodine, β-Luo Ye alkali, lycofoline, point leaf lycoclavanol alkali, hydroxypropyl [4aR-(4a.alpha.,5.alpha.,10b.alpha.,12R .), lyconnotine alcohol alkali, Herba Lycopodii Obscuri lycoclavanol alkali, table Herba Lycopodii Obscuri lycoclavanol alkali etc.There is expelling wind and removing dampness, channels sootheing and network vessel quickening, effect of blood circulation promoting and blood stasis dispelling.For rheumatic arthralgia, lumbago and skelalgia, numb limbs and tense tendons, osteopatia sprain, poliomyelitis sequela.
Bombyx Batryticatus: salty in the mouth, pungent, property is put down.Return liver, lung, stomach warp.Larva for Can E section insecticide silkworm 4-5 age infects (or artificial vaccination) muscardine and lethal dry body.There is expelling wind for relieving convulsion, effect of dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus; Submandibular lymph nodes is scorching, facial paralysis.
Flos lupuli (Flos Humuli Lupuli): bitter in the mouth, slightly cool in nature.Return liver, stomach warp.The wounded in the battle fruit ear of immaturity for moraceae plants Flos lupuli (Flos Humuli Lupuli).Containing humuladienone, humulenone-Ⅱ, α-remove dihydro cadinene, γ-remove dihydro Rhizoma Acori Graminei alkene, 2-M3BOL, astragalin, Isoquercitrin, globulariacitrin etc.There is invigorating the stomach and promoting digestion, inducing diuresis to remove edema, effect of anti-consumptive disease antiinflammatory.For dyspepsia, abdominal distention, edema, cystitis, pulmonary tuberculosis, cough, insomnia, leprosy.
Technical advantage of the present invention is mainly reflected in:
1, the present invention adopts that common Chinese medicine material is refining to be formed, and have effect of opening the orifice and activating blood circulation, dredge the meridian passage, nourishing YIN for suppressing the hyperactive YANG, suppressing the hyperactive liver to relieve the wind syndrome, can improve cerebral tissue blood supply oxygen-supplying amount, recover cerebral nervous system function, treatment cerebral infarction is evident in efficacy.
2, invention formulation is based on Basic Theories of Chinese Medicine, adopts Common Chinese Herbs to refine and forms, and avoids the injury that routine operation is treated, western medicine brings to patient, does not damage the function such as liver, kidney, do not leave sequela to patient body.
3, disease such as invention formulation treatment cerebral hemorrhage, cerebral infarction etc. has significant curative effect, and can effective anticoagulant and increase cerebral blood flow, the symptoms such as the hemiplegia caused for cerebral infarction and sequela thereof, contracture numbness, facial hemiparalysis, slurred speech, hypomnesis, facial hemiparalysis, extremity are stiff have significant curative effect.
4, invention formulation selected materials great majority are Chinese medicine material, and medical material is easy to get, and cost is low, has no side effect, and operation is simple, safe and reliable, evident in efficacy.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1for curing the preparation of cerebral infarction, taking off and stating primary raw material and be prepared from (getting 60g for every part): Rhizoma Acori Graminei 8 parts; Fructus Phoenicis Dactyliferae 9 parts; Herba menyanthis 11 parts; Folium Perillae 10 parts; Radix Habenariae Dentatae 7 parts; Arisaema Cum Bile 8 parts; Herba Pouzolziae Zeylanicae 6 parts; Herba Stachytarphetae Jamaicensis 7 parts; Flos Caraganae Franchetianae 9 parts; Herba Selaginellae Involventis 8 parts; Herba Cistanches 10 parts; Herba Lycopodii Obscuri 7 parts; Bombyx Batryticatus 6 parts; Flos lupuli (Flos Humuli Lupuli) 9 parts.
The preparation method of the above-mentioned preparation decoction for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, adds Arisaema Cum Bile, continues slow fire and stir-fries 18 minutes, take out, cool, grind into powder, cross 160 mesh sieves;
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 9 hours, take out, fried dry, pulverize, cross 160 mesh sieves;
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 45 minutes, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, sterile packaged.
Instructions of taking: each 100-150ml, every day 2 times, 8 days courses for the treatment of.
embodiment 2for curing the preparation of cerebral infarction, taking off and stating primary raw material and be prepared from (getting 30g for every part): Rhizoma Acori Graminei 14 parts; Fructus Phoenicis Dactyliferae 13 parts; Herba menyanthis 16 parts; Folium Perillae 14 parts; Radix Habenariae Dentatae 13 parts; Arisaema Cum Bile 12 parts; Herba Pouzolziae Zeylanicae 14 parts; Herba Stachytarphetae Jamaicensis 15 parts; Flos Caraganae Franchetianae 14 parts; Herba Selaginellae Involventis 15 parts; Herba Cistanches 16 parts; Herba Lycopodii Obscuri 14 parts; Bombyx Batryticatus 10 parts; Flos lupuli (Flos Humuli Lupuli) 15 parts.
The preparation method of the above-mentioned preparation granules agent for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, adds Arisaema Cum Bile, continues slow fire and stir-fries 18 minutes, take out, cool, grind into powder, cross 160 mesh sieves;
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 9 hours, take out, fried dry, pulverize, cross 160 mesh sieves;
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 45 minutes, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, takes after melting, every day 2 times, 8 days courses for the treatment of by warm water.
model case onefire XX, man, 72 years old, people from Handan in Hebei province.Without feeling suddenly headache under obvious inducement, left limb is weak, and left upper extremity can not hold thing, and left lower extremity can not be walked, so remove hospital admission, CT shows cerebral infarction.After falling the treatments such as intracranial pressure, blood vessel dilating, hormone, the metabolism of promotion brain cell, without obviously alleviating, still bradykinesia, speech is ambiguous, can not exchange very well, and companion's left limb is unable, and praising walking can not.
Take the present invention for cure cerebral infarction 2 courses for the treatment of of preparation (embodiment 2) after, can slow walking under the assisting in of layman, arm muscular strength takes a turn for the better, and can clench fist.After continuing to take 2 courses for the treatment of, hands can be stretched and can lift, and lower limb muscular strength takes a turn for the better.Later stage learns that life can be taken care of oneself completely in following up a case by regular visits to, and speech is comparatively fluent, and trick is stretched and bent effectively.
embodiment 3for curing the preparation of cerebral infarction, taking off and stating primary raw material and be prepared from (getting 50g for every part): Rhizoma Acori Graminei 10 parts; Fructus Phoenicis Dactyliferae 10 parts; Herba menyanthis 13 parts; Folium Perillae 11 parts; Radix Habenariae Dentatae 9 parts; Arisaema Cum Bile 9 parts; Herba Pouzolziae Zeylanicae 9 parts; Herba Stachytarphetae Jamaicensis 10 parts; Flos Caraganae Franchetianae 11 parts; Herba Selaginellae Involventis 11 parts; Herba Cistanches 12 parts; Herba Lycopodii Obscuri 10 parts; Bombyx Batryticatus 7 parts; Flos lupuli (Flos Humuli Lupuli) 11 parts.
The preparation method of the above-mentioned preparation concentrated pill for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, adds Arisaema Cum Bile, continues slow fire and stir-fries 18 minutes, take out, cool, grind into powder, cross 160 mesh sieves;
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 9 hours, take out, fried dry, pulverize, cross 160 mesh sieves;
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 45 minutes, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make the concentrated pill that diameter is 4mm, sterile packaged.
Using method: each 8 balls, with warm water delivery service, every day 2 times, 8 days courses for the treatment of.
embodiment 4for curing the preparation of cerebral infarction, taking off and stating primary raw material and be prepared from (getting 20g for every part): Rhizoma Acori Graminei 12 parts; Fructus Phoenicis Dactyliferae 12 parts; Herba menyanthis 15 parts; Folium Perillae 13 parts; Radix Habenariae Dentatae 11 parts; Arisaema Cum Bile 11 parts; Herba Pouzolziae Zeylanicae 11 parts; Herba Stachytarphetae Jamaicensis 12 parts; Flos Caraganae Franchetianae 13 parts; Herba Selaginellae Involventis 13 parts; Herba Cistanches 14 parts; Herba Lycopodii Obscuri 12 parts; Bombyx Batryticatus 9 parts; Flos lupuli (Flos Humuli Lupuli) 13 parts.
The preparation method of the above-mentioned formulation tablet for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, adds Arisaema Cum Bile, continues slow fire and stir-fries 18 minutes, take out, cool, grind into powder, cross 160 mesh sieves;
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 9 hours, take out, fried dry, pulverize, cross 160 mesh sieves;
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 45 minutes, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make tablet.
Using method: each 2-3 sheet, every day 2 times, 8 days courses for the treatment of.
model case twoglad XX, female, 64 years old, people from Dezhou City Shandong Province.Certain day morning before about 7 years falls down to the ground suddenly, finds that right crus of diaphragm can not move when household helps, unable, the right hand loses muscular strength, so remove hospital therapy, CT points out left cerebral infarction, improvement is had no after treating one week, state of an illness Progressive symmetric erythrokeratodermia increases the weight of, and has occurred the performance of brain dementia, in paroxysmal, clear-headed muddled once in a while once in a while, even occurred gatism, and arm starts swelling, can not move.
Take the present invention for cure cerebral infarction 2 courses for the treatment of of preparation (embodiment 4) after, mind takes a turn for the better, and right arm swelling is gradually moved back, and upper arm muscular strength takes a turn for the better, can left and right pendulum, and mind recovers as usual, clearheaded.After continuing to take 2 courses for the treatment of, life can be taken care of oneself substantially, and finger is clenched fist strong, flexible, talks more fluent.Follow up a case by regular visits to and do not recur so far, recover better, the sensation can benumbed when walking disappears.
embodiment 5for curing the preparation of cerebral infarction, taking off and stating primary raw material and be prepared from (getting 40g for every part): Rhizoma Acori Graminei 11 parts; Fructus Phoenicis Dactyliferae 11 parts; Herba menyanthis 14 parts; Folium Perillae 12 parts; Radix Habenariae Dentatae 10 parts; Arisaema Cum Bile 10 parts; Herba Pouzolziae Zeylanicae 10 parts; Herba Stachytarphetae Jamaicensis 11 parts; Flos Caraganae Franchetianae 12 parts; Herba Selaginellae Involventis 12 parts; Herba Cistanches 13 parts; Herba Lycopodii Obscuri 11 parts; Bombyx Batryticatus 8 parts; Flos lupuli (Flos Humuli Lupuli) 12 parts.
The preparation method of the above-mentioned preparation capsule for curing cerebral infarction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, adds Arisaema Cum Bile, continues slow fire and stir-fries 18 minutes, take out, cool, grind into powder, cross 160 mesh sieves;
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 9 hours, take out, fried dry, pulverize, cross 160 mesh sieves;
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 45 minutes, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.25(25 DEG C) thick paste, dry, pulverize, cross 190 mesh sieves, make capsule (0.5g/ grain).
Instructions of taking: each 2-3 grain, every day 2 times, 8 days courses for the treatment of.
test example:in order to verify that the present invention is used for curing the curative effect of the preparation (embodiment 5) of cerebral infarction, do contrast test in May ,-2012 in February, 2010:
General data: screening 260 routine Cerebral Infarction Patients, wherein minimal ages 43 years old, max age 73 years old, 54.7 years old mean age.Be divided into experimental group and matched group two groups (wherein experimental group 160 people, matched group 100 people) at random, two groups are compared there was no significant difference, have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: 1. onset is anxious, and in very short time of being everlasting, symptom peaks, minority is that staged Progressive symmetric erythrokeratodermia worsens.2. head x-ray is taken the photograph sheet and sometimes can be found that there is calcification shadow in internal carotid artery siphon portion.3. cerebral angiography can find arterial occlusion or narrow position, the situations such as blood vessel constriction, displacement and Doppler flow mapping caused by cerebral edema.4. brain CT and nuclear magnetic resonance check can show the position of cerebral infarction, size and around cerebral edema situation and with or without hemorrhage sign etc. thereof.5. some patients has of short duration confusion, headache, tic, and quadriplegia appears in severe patient, feed dysphagia, hemiplegia, forced grasping reflex and urinary incontinence.
Usage and dosage: experimental group takes the present invention for curing the preparation of cerebral infarction, each serving with 2, every day 2 times, 8 days courses for the treatment of; Matched group takes other medicine (as XUESAITONG RUANJIAONANG, NAOXINTONG JIAONANG), wherein, XUESAITONG RUANJIAONANG: oral, each 100-200mg(1-2 grain), every day 3 times 4 weeks is a course for the treatment of.NAOXINTONG JIAONANG: oral, a 2-4 grain, 3 times on the one, or follow the doctor's advice.
Criterion of therapeutical effect: cure: all malaise symptoms disappears, every Index for examination is normal, and energy and muscle power obviously strengthen, and at least half a year without recurrence; Effective: all malaise symptoms alleviate or partial disappearance, every Index for examination is normal, and energy and muscle power strengthen; Invalid: worsening appears in the unchanged even state of an illness of all malaise symptoms.
Adopt the matched group of other drug and take the present invention for curing the Comparison of therapeutic of the experimental group of the preparation of cerebral infarction, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, take the present invention and be only 3.12% for the inefficiency of the preparation of curing cerebral infarction, cure rate is up to 70%, effective percentage is up to 96.88%, and adopting the inefficiency had up to 23% of other treatment scheme, cure rate only reaches 36%, and effective percentage is also only 77%.Experiment shows that the present invention is for curing the preparation of cerebral infarction compared with other drug, and evident in efficacy, cure rate is high, and inefficiency is low.Invention formulation more can improve cerebral tissue blood supply oxygen-supplying amount at short notice, recover cerebral nervous system function, disease such as treatment cerebral hemorrhage, cerebral infarction etc. has significant curative effect, and can effective anticoagulant and increase cerebral blood flow, the symptoms such as the hemiplegia caused for cerebral infarction and sequela thereof, contracture numbness, facial hemiparalysis, slurred speech, hypomnesis, facial hemiparalysis, extremity are stiff have significant curative effect.Invention formulation treatment cerebral infarction short treating period, instant effect, safety has no side effect, be a kind ofly be applicable to cerebral infarction, good medicine that cerebrovascular sequelae patient takes.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. for curing the preparation of cerebral infarction, it is characterized in that, taking off the primary raw material stating weight proportion and being prepared from: Rhizoma Acori Graminei 8-14 part; Fructus Phoenicis Dactyliferae 9-13 part; Herba menyanthis 11-16 part; Folium Perillae 10-14 part; Radix Habenariae Dentatae 7-13 part; Arisaema Cum Bile 8-12 part; Herba Pouzolziae Zeylanicae 6-14 part; Herba Stachytarphetae Jamaicensis 7-15 part; Flos Caraganae Franchetianae 9-14 part; Herba Selaginellae Involventis 8-15 part; Herba Cistanches 10-16 part; Herba Lycopodii Obscuri 7-14 part; Bombyx Batryticatus 6-10 part; Flos lupuli (Flos Humuli Lupuli) 9-15 part.
2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Acori Graminei 10-12 part; Fructus Phoenicis Dactyliferae 10-12 part; Herba menyanthis 13-15 part; Folium Perillae 11-13 part; Radix Habenariae Dentatae 9-11 part; Arisaema Cum Bile 9-11 part; Herba Pouzolziae Zeylanicae 9-11 part; Herba Stachytarphetae Jamaicensis 10-12 part; Flos Caraganae Franchetianae 11-13 part; Herba Selaginellae Involventis 11-13 part; Herba Cistanches 12-14 part; Herba Lycopodii Obscuri 10-12 part; Bombyx Batryticatus 7-9 part; Flos lupuli (Flos Humuli Lupuli) 11-13 part.
3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Acori Graminei 11 parts; Fructus Phoenicis Dactyliferae 11 parts; Herba menyanthis 14 parts; Folium Perillae 12 parts; Radix Habenariae Dentatae 10 parts; Arisaema Cum Bile 10 parts; Herba Pouzolziae Zeylanicae 10 parts; Herba Stachytarphetae Jamaicensis 11 parts; Flos Caraganae Franchetianae 12 parts; Herba Selaginellae Involventis 12 parts; Herba Cistanches 13 parts; Herba Lycopodii Obscuri 11 parts; Bombyx Batryticatus 8 parts; Flos lupuli (Flos Humuli Lupuli) 12 parts.
4., according to the arbitrary described preparation of claim 1-3, it is characterized in that: the preparation method of described decoction, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, add yellow wine, moistening 8-10 hour, take out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, sterile packaged.
5. the preparation method of preparation according to claim 4, it is characterized in that: the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass, and the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass.
6., according to the arbitrary described preparation of claim 1-3, it is characterized in that: the preparation method of described granule, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into the thick paste of relative density 1.10-1.20, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
7. the preparation method of preparation according to claim 6, is characterized in that: step (4) is preferably concentrated into the thick paste of relative density 1.13-1.17, is more preferably the thick paste being concentrated into relative density 1.15.
8., according to the arbitrary described preparation of claim 1-3, it is characterized in that: the preparation method of described concentrated pill, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, be concentrated into the thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15) of relative density 1.10-1.20, (preferred diameter is 3-5mm to make concentrated pill, being more preferably diameter is 4mm), sterile packaged.
9., according to the arbitrary described preparation of claim 1-3, it is characterized in that: the preparation method of described tablet, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make tablet.
10., according to the arbitrary described preparation of claim 1-3, it is characterized in that: the preparation method of described capsule, step is as follows:
(1) Fructus Phoenicis Dactyliferae and Bombyx Batryticatus are smashed, dry, be placed in pot, slow fire is fried to surperficial micro-yellow, add Arisaema Cum Bile, continue slow fire and to stir-fry 15-20 minute, take out, cool, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Habenariae Dentatae, Herba Cistanches and Flos lupuli (Flos Humuli Lupuli) gross mass), moistening 8-10 hour, takes out, fried dry, pulverize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) Rhizoma Acori Graminei, Herba Stachytarphetae Jamaicensis and Flos Caraganae Franchetianae are cleaned, be placed in marmite, add water, heating extraction 40-50 minute, add Herba menyanthis, Folium Perillae, Herba Pouzolziae Zeylanicae, Herba Selaginellae Involventis and Herba Lycopodii Obscuri, continue heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(4) step (1)-(2) gained medicated powder is joined in step (3) gained filtrate, stir, hold over night, filter, the thick paste being concentrated into relative density 1.20-1.30 (is preferably concentrated into the thick paste of relative density 1.23-1.27, be more preferably the thick paste being concentrated into relative density 1.25), dry, pulverize, cross 180-200 mesh sieve, make capsule (preferred 0.4-0.6g/ grain, is more preferably 0.5g/ grain).
CN201510635245.6A 2015-09-30 2015-09-30 Preparation for treating cerebral infarction and preparation method thereof Pending CN105148021A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979044A (en) * 2010-10-23 2011-02-23 许文成 Medicament for treating cerebral infarction and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979044A (en) * 2010-10-23 2011-02-23 许文成 Medicament for treating cerebral infarction and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
鲍学全等: "《疑难病中医治疗及研究》", 31 October 1995 *

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