CN105147519A - Freeze-drying heat transfer fixing device for card bottle - Google Patents
Freeze-drying heat transfer fixing device for card bottle Download PDFInfo
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- CN105147519A CN105147519A CN201510506890.8A CN201510506890A CN105147519A CN 105147519 A CN105147519 A CN 105147519A CN 201510506890 A CN201510506890 A CN 201510506890A CN 105147519 A CN105147519 A CN 105147519A
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- heat transfer
- bottle
- freeze
- fixing device
- clamped bottle
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Abstract
The invention discloses a freeze-drying heat transfer fixing device for a card bottle, belonging to the technical field of freeze-drying. The freeze-drying heat transfer fixing device for the card bottle comprises a device body, wherein a bottle hole is formed in the device body, and the device body is made of silica gel. The freeze-drying heat transfer fixing device is easily available in materials, easy to manufacture, and suitable for large-scale popularization and manufacturing; the freeze-drying heat transfer fixing device can be customized according to sizes of card bottles of different specifications and shelves of a freeze dryer, and is wide in application range; the freeze-drying heat transfer fixing device is convenient for automatic charge and later-stage plug adding; the card bottle can be well fixed, silica gel has elasticity, thus being capable of closely contacting the card bottle regardless of the influences of the processing error of the card bottle, and the heat transfer effect is good; with the adoption of silica gel, since silica gel has inertia to the medicine, no influences are generated to the quality and the safety of the medicine.
Description
Technical field
The present invention relates to freeze drying technology field, be specifically related to a kind of clamped bottle lyophilizing heat transfer fixture.
Background technology
Clamped bottle has another name called borosilicate glass sleeve for pen type syringe, is the inner container for splendid attire liquid drugs injection or powder injection formulation of pen-type injector.The similar syringe not having push rod of clamped bottle, is equivalent to " not having bottle with the end ".This bottle of head is equipped with the injection needle of rubber seal protection, and bottleneck plug aluminium lid sealing, afterbody rubber piston seals.Clamped bottle is inserted in reusable cassette injection holder or injection pen and is used, and use procedure medicinal liquid is any component contact with syringe not.
The new a kind of new glass tube vial released since clamped bottle is 21st century, due in injection process, medicinal liquid can not contact with air, and glass can not be produced as peace cuts open bottle to cut, therefore relative to other glass tube vial, the injection process of clamped bottle is safer, and use procedure is simple, therefore enjoys the favor of world's pharmaceutical industry.Clamped bottle preparation mainly contains two kinds, hydro-acupuncture preparation and powder injection formulation, and clamped bottle hydro-acupuncture preparation obtains mainly through canning means under laminar flow cleaning measure, and clamped bottle powder injection formulation is then obtained by the subpackage of the aseptic powder injection under laminar flow cleaning measure.Due to the structural uniqueness of clamped bottle: 1, clamped bottle does not have the end, the clamped bottle (head Zha Gai, afterbody does not add piston) that medicinal liquid is housed need when placing in freeze dryer head under, afterbody is upper, and due to head less, the placement of clamped bottle on freeze-drying machine partition board cannot be completed; 2, in freeze-drying process, no matter head downwards or tail down placement, owing to not having heat transfer area between clamped bottle inner liquid medicine and freeze-drying machine partition board, therefore cannot realize the exchange heat between freeze-drying process herb liquid and shelf.Therefore, current clamped bottle can not utilize the direct lyophilizing of freeze dryer, therefore there is no clamped bottle freeze-dried powder.
Summary of the invention
The present invention is directed to clamped bottle set forth above can not the problem of direct lyophilizing, and a kind of clamped bottle lyophilizing heat transfer of research design fixture.The technological means that the present invention adopts is as follows:
A kind of clamped bottle lyophilizing heat transfer fixture, comprise device body, described device body is provided with a bottle hole.
Further, described bottle hole is shoulder hole structure, and described shoulder hole comprises the hole, large footpath and diameter holes that are connected with one heart, and the diameter in hole, described large footpath is less than or equal to the external diameter of clamped bottle bottle.
Further, the diameter of described diameter holes equals the external diameter of clamped bottle Zha Gai.
Further, described hole, large footpath and diameter holes junction are the curved surface can fitted with the shoulder of clamped bottle.
Further, described device body is made up of silica gel
Compared with the prior art, a kind of clamped bottle lyophilizing heat transfer fixture of the present invention has the following advantages:
1, making of the present invention is drawn materials conveniently, makes simple, is convenient to large-scale popularization and produces;
2, the present invention can customize according to the clamped bottle of different size and freeze-drying machine partition board size, applied widely;
3, the present invention is convenient to automatic charge (upper bottle) and the later stage jumps a queue;
4, the present invention can be fixed clamped bottle preferably, and silica gel has elasticity, and not by the impact of clamped bottle mismachining tolerance, contact with clamped bottle closely, heat-transfer effect is good;
5, the present invention uses silica gel material, and silica gel has inertia to medicine, can not impact the quality of medicine and safety.
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment of the present invention.
Fig. 2 is embodiment of the present invention using state schematic diagram.
Detailed description of the invention
As shown in Figure 1-2, a kind of clamped bottle lyophilizing heat transfer fixture, comprise device body 1, described device body 1 is provided with bottle hole 2, and described device body 1 is made up of silica gel.
Described bottle hole 2 is shoulder hole structure, comprise coaxial connected hole, large footpath 3 and diameter holes 4, the diameter in hole, described large footpath 3 is less than or equal to the external diameter of clamped bottle 5 bottle, preferably be slightly less than the external diameter of clamped bottle 5, clamped bottle 5 can be positioned in bottle hole 2 by the downward diameter of microcephaly, because silica gel has certain elasticity, can be combined with the intimate of clamped bottle 5, the untight situation of contact avoiding the reason such as fabrication error due to clamped bottle 5 to cause, increases thermal conductivity.The diameter of described diameter holes 4 is less than or equal to the external diameter of clamped bottle 5 Zha Gai.
Hole, described large footpath 3 and diameter holes 4 junction are the curved surface can fitted with the shoulder of clamped bottle 5, make shoulder portion also can carry out heat exchange preferably.
During use, first clamped bottle 5 is installed medicinal liquid, then clamped bottle 5 head that medicinal liquid is housed is loaded bottle hole 2 downwards, the bottom card of the head of clamped bottle 5 and the heat transfer fixture described in the present embodiment is neat, then heat transfer fixture is together positioned on freeze-drying machine partition board 6 together with the clamped bottle 5 placed, carries out lyophilizing according to the lyophilizing program of freeze dryer.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (5)
1. a clamped bottle lyophilizing heat transfer fixture, comprises device body, it is characterized in that: described device body is provided with a bottle hole.
2. clamped bottle lyophilizing heat transfer fixture according to claim 1, it is characterized in that: described bottle hole is shoulder hole structure, described shoulder hole comprises the hole, large footpath and diameter holes that are connected with one heart, and the diameter in hole, described large footpath is less than or equal to the external diameter of clamped bottle bottle.
3. clamped bottle lyophilizing heat transfer fixture according to claim 2, is characterized in that: the diameter of described diameter holes equals the external diameter of clamped bottle Zha Gai.
4. clamped bottle lyophilizing heat transfer fixture according to claim 2, is characterized in that: described hole, large footpath and diameter holes junction are the curved surface can fitted with the shoulder of clamped bottle.
5., according to the clamped bottle lyophilizing heat transfer fixture in claim 1-4 described in any one, it is characterized in that: described device body is made up of silica gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506890.8A CN105147519A (en) | 2015-08-18 | 2015-08-18 | Freeze-drying heat transfer fixing device for card bottle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506890.8A CN105147519A (en) | 2015-08-18 | 2015-08-18 | Freeze-drying heat transfer fixing device for card bottle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105147519A true CN105147519A (en) | 2015-12-16 |
Family
ID=54788818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510506890.8A Pending CN105147519A (en) | 2015-08-18 | 2015-08-18 | Freeze-drying heat transfer fixing device for card bottle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105147519A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3358825A (en) * | 1965-12-27 | 1967-12-19 | Cutter Lab | Pharmaceutical package |
| CN2157778Y (en) * | 1993-04-07 | 1994-03-02 | 肖锡文 | Bottom base of ampule |
| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| US20090065470A1 (en) * | 2007-09-10 | 2009-03-12 | Anthony Joseph Giralo | Insulin bottle holder |
| US20150148752A1 (en) * | 1998-11-12 | 2015-05-28 | Tolmar Therapeutics, Inc. | Article of manufacture containing lyophilized leuprolide acetate |
| CN204881131U (en) * | 2015-08-18 | 2015-12-16 | 大连双瑞科技有限公司 | Card formula bottle freeze -drying heat transfer fixing device |
-
2015
- 2015-08-18 CN CN201510506890.8A patent/CN105147519A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3358825A (en) * | 1965-12-27 | 1967-12-19 | Cutter Lab | Pharmaceutical package |
| CN2157778Y (en) * | 1993-04-07 | 1994-03-02 | 肖锡文 | Bottom base of ampule |
| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| US20150148752A1 (en) * | 1998-11-12 | 2015-05-28 | Tolmar Therapeutics, Inc. | Article of manufacture containing lyophilized leuprolide acetate |
| US20090065470A1 (en) * | 2007-09-10 | 2009-03-12 | Anthony Joseph Giralo | Insulin bottle holder |
| CN204881131U (en) * | 2015-08-18 | 2015-12-16 | 大连双瑞科技有限公司 | Card formula bottle freeze -drying heat transfer fixing device |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160205 Address after: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant after: Song Zhantao Address before: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant before: DALIAN TIANREY SCIENCE AND TECHNOLOGY CO., LTD. |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151216 |
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| RJ01 | Rejection of invention patent application after publication |