CN105147250B - A kind of portable optical coherence chromatographic imaging instrument - Google Patents
A kind of portable optical coherence chromatographic imaging instrument Download PDFInfo
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- CN105147250B CN105147250B CN201510509005.1A CN201510509005A CN105147250B CN 105147250 B CN105147250 B CN 105147250B CN 201510509005 A CN201510509005 A CN 201510509005A CN 105147250 B CN105147250 B CN 105147250B
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Abstract
The present invention discloses a kind of portable optical coherence chromatographic imaging instrument, wideband light source including the single beam with different wave length can be sent out, the slit of linear light beam is formed after so that single beam is passed through, the linear light beam is separated into the beam splitter of reference beam and measuring beam, reference beam is with measuring beam respectively through reference mirror, object lens reflect or form interfering beam on beam splitter after scattering, the interfering beam forms the emergent light with different wave length after grating by dispersion, emergent light can be obtained the two-dimentional tomograph of object to be measured after portable or wearable smart machine.The imager uses portable or wearable smart machine instead of existing spectrometer, can realize carry, at any time diagnosis, it is easy to operate and and it is cheap, be conducive to be widely used, and be easily achieved tele-medicine and big data analysis.
Description
Technical field
The present invention relates to optical image technology field, more particularly to a kind of portable optical coherence chromatographic imaging instrument.
Background technology
Optical coherent chromatographic imaging（OCT）It is a kind of emerging optical image technology.It in a manner of Noninvasive, it is high
Speed form high-resolution biological tissue's sectional view.Since the technology comes out since 1991, ground for clinical diagnosis and medical treatment
Study carefully and brings significant impact.In past 10 years, every year there is over 20,000,000 patients become OCT image technology by
Beneficial person.However existing OCT equipment manufacturing costs are expensive（It is roughly equal to ten thousand RMB of 60-80/platform）, individual can not undertake cost of equipment, seriously
Hinder the universal of this efficient diagnosis technology；Moreover, existing OCT equipment volumes, weight are larger, it cannot achieve and carry,
Also it is influenced to a certain extent to be more widely applied.
And currently, a typical SD-OCT equipment, shown in Figure 1, including consisting of part：Light source 110；Interference
Instrument 120；Reference arm 130；Spectrometer 140；Sample arm 150.Interferometer usually has 4 interfaces, be separately connected light source, reference arm,
Four spectrometer, sample arm parts.The output light of wideband light source is divided into two parts by entering after interferometer, and a part is through dry
Interferometer reaches sample arm, and another part reaches reference arm.The light of arrival sample arm backtracking interferometer after sample scatters；Together
Sample reaches the light of reference arm after reference mirror reflects by backtracking interferometer.The two-beam of interferometer is returned to dry
It is interfered at interferometer, partial coherence light reaches spectrometer through interferometer, and spectrometer is converted into electricity after receiving interference light
Signal.Computer is read from spectrometer include the spectrometer output data of spectrum interference signal, by spectral domain linearity correction with
The cross-section image of sample is obtained after inverse-Fourier variation.In all components, spectrometer and computer are the most complicated, expensive.
Invention content
The object of the present invention is to provide a kind of cheap, easy to carry, the portable optical phase dried layer that can diagnose at any time
Analyse imager.
In order to achieve the above objectives, the technical solution adopted by the present invention is：A kind of portable optical coherence chromatographic imaging instrument, packet
It includes：
Wideband light source can send out the single beam with different wave length；The wideband light source can send out wavelength be l1, l2 ...,
The single beam of ln；
Slit goes out positioned at the wideband light source on light path, and the single beam forms linear light beam after the slit；
Beam splitter goes out positioned at the linear light beam on light path, and the linear light beam is separated into and is directed to reference to reflection
The reference beam of mirror, the measuring beam for being directed to object to be measured；
Collimation lens makes the linear light beam formed after the slit between the slit and the beam splitter
Collimation；
Object lens make the measuring beam collimatedly concentrate on described wait between the beam splitter and the object to be measured
It surveys on object；
Grating, the reference beam, the measuring beam are reflected respectively through the reference mirror, the object lens or scattering
Interfering beam is formed in the beam splitter neutralizing light afterwards, the grating is located at the going out on light path of the interfering beam, described to do
It relates to light beam and dispersion occurs after the grating, form the emergent light with different wave length；
Portable or wearable smart machine, the smart machine include camera lens, camera, camera, it is described go out
It penetrates on the photosurface for arriving separately at the camera after light incidence is focused by the camera lens and forms different line focus, it is described
Camera detect obtained through Fourier transformation after the different pixels signal of the camera output object to be measured two dimension it is disconnected
Layer figure.
Preferably, the light source is LED wideband light sources.
Preferably, the smart machine is mobile phone or tablet computer.
It is further preferred that having centre wavelength light beam identical with the wideband light source wavelength, institute in the emergent light
State camera lens, the central point of the camera is respectively positioned on the going out on light path of the emergent light, pass through and calculate the grating outgoing
The angle of emergence of light adjusts the position between the camera, the camera lens and the grating, the outgoing of the grating emergent light
Angle meets：
Relational expression：nλ=d(sinθ+sinθ’)；
Wherein λ is the wavelength of the centre wavelength light beam, the centre wavelength of the as described wideband light source；N is optical grating diffraction
Grade；D is grating constant；θ is grating incident angle, the angle between the as described interfering beam and the grating normal；θ ' is grating
The angle of emergence, the angle between the as described emergent light and the grating normal.
Due to the application of the above technical scheme, the present invention has following advantages compared with prior art：The present invention's is portable
Formula optical coherent chromatographic imaging instrument is taken by the way that grating and portable intelligent device are arranged on light path in going out for interfering beam
Band is convenient, can be diagnosed at any time, and it compared with existing spectrometer, price is lower, and is easily achieved tele-medicine and big
Data analysis.
Description of the drawings
Attached drawing 1 is the structural schematic diagram of SD-OCT equipment in the prior art；
Attached drawing 2 is a kind of structural schematic diagram of portable optical coherence chromatographic imaging instrument of the present invention；
Wherein：110, light source；120, interferometer；130 reference arms；140, spectrometer；150, sample arm；
1, wideband light source（LED wideband light sources）；2, slit；3, collimation lens；4, beam splitter；5, reference mirror；6, object
Mirror；7, object to be measured；8, grating；9, smart machine；91, camera lens；92, camera.
Specific implementation mode
Below in conjunction with the accompanying drawings and specific embodiment is further elaborated technical scheme of the present invention.
It is shown in Figure 2, a kind of portable optical coherence chromatographic imaging instrument, including wideband light source 1, which can
Send out the single beam with different wave length；Slit 2, positioned at going out on light path for wideband light source 1, which passes through the slit 2
After form linear light beam；The linear light beam is separated into positioned at going out on light path for linear light beam and is directed to reference by beam splitter 4
The reference beam of speculum 5, the measuring beam for being directed to object 7 to be measured；Collimation lens 3 makes between slit 2 and beam splitter 4
The linear light beam collimation formed after slit 2；Object lens 6 make measuring beam collimatedly collect between beam splitter 4 and object to be measured 7
In on object 7 to be measured；Grating 8, the reference beam, measuring beam are respectively after reference mirror 5, the transmitting of object lens 6 or scattering
Interfering beam is formed in 4 neutralizing light of beam splitter, which is located at the going out on light path of interfering beam, and the interfering beam is through the light
Dispersion occurs after grid 8, being formed has different wave length emergent light, is then examined by portable or wearable smart machine 9
It surveys.Herein, which is LED wideband light sources 1, has low cost, body compared with point light source using LED wideband light sources 1
Product advantage small, low in energy consumption, the light beam that LED wideband light sources 1 itself are sent out more dissipate, and linear light beam is formed after slit 2,
It need to can just become the very strong approximate collimated light beam of a directionality by increasing collimation lens 3.
Herein, the testing agency of the imager is portable or wearable smart machine 9, in the present embodiment, should
Smart machine 9 is mobile phone, can also be tablet computer.The smart machine 9 includes camera lens 91, camera 92, camera, outgoing
Light incidence forms different line focus, camera on the photosurface by arriving separately at the camera 92 after the camera lens 91 focusing
Through Fourier transformation the two-dimentional tomograph of object 7 to be measured is obtained after detecting the different picture element signals of the camera 92 output.And
If it is mobile phone is used as smart machine 9, then it is shown on mobile phone screen by mobile phone application.Herein, pass through the intelligence
Can equipment 9 instead of spectrometer in the prior art, it is cheap, simple in structure, easy to carry, easy to operate, be easy to real
Existing tele-medicine and big data analysis.
Herein, the emergent light in the emergent light with different wave length which forms after 8 dispersion of grating
In have centre wavelength light beam identical with the centre wavelength of wideband light source 1, the camera lens 91, camera 92 center be respectively positioned on
The emergent light goes out on light path, and camera 92, camera lens 91 and grating 8 are adjusted by calculating the angle of emergence of grating emergent light
Between position, the angle of emergence of the grating emergent light meets：
Relational expression：nλ=d(sinθ+sinθ’)；
Wherein λ is the wavelength of centre wavelength light beam, as the centre wavelength of wideband light source 1；N is optical grating diffraction grade；D is light
Grid constant；θ is grating incident angle, as the angle between interfering beam and grating normal；θ ' is the grating angle of emergence, as emergent light
With the angle between grating normal.
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to allow person skilled in the art
Scholar cans understand the content of the present invention and implement it accordingly, and it is not intended to limit the scope of the present invention.It is all according to the present invention
Equivalent change or modification made by Spirit Essence, should be covered by the protection scope of the present invention.
Claims (3)
1. a kind of portable optical coherence chromatographic imaging instrument, which is characterized in that including：
Wideband light source can send out the single beam with different wave length；
Slit goes out positioned at the wideband light source on light path, and the single beam forms linear light beam after the slit；
Beam splitter goes out positioned at the linear light beam on light path, and the linear light beam is separated into and is directed to reference mirror
Reference beam, the measuring beam for being directed to object to be measured；
Collimation lens makes the linear light beam formed after the slit collimate between the slit and the beam splitter；
Object lens make the measuring beam collimatedly concentrate on described to be measured right between the beam splitter and the object to be measured
As upper；
Grating, the reference beam, the measuring beam respectively through the reference mirror, the object lens reflection or scattering after
The beam splitter neutralizing light forms interfering beam, and the grating is located at the going out on light path of the interfering beam, the interference light
Dispersion occurs after grating described in Shu Jing, forms the emergent light with different wave length；
Portable or wearable smart machine, the smart machine include camera lens, camera, camera, the emergent light
Incidence forms different line focus, the camera shooting on the photosurface by arriving separately at the camera after camera lens focusing
Head detects and obtains the two-dimentional tomograph of the object to be measured through Fourier transformation after the different pixels signal of camera output；
There is centre wavelength light beam identical with the wideband light source wavelength, the camera lens, the phase in the emergent light
The central point of machine is respectively positioned on the going out on light path of the emergent light, by calculating the angle of emergence of the grating emergent light to adjust
The position between camera, the camera lens and the grating is stated, the angle of emergence of the grating emergent light meets：
Relational expression：nλ=d(sinθ+sinθ’)；
Wherein λ is the wavelength of the centre wavelength light beam, the centre wavelength of the as described wideband light source；N is optical grating diffraction grade；d
It is grating constant；θ is grating incident angle, the angle between the as described interfering beam and the grating normal；θ ' is grating outgoing
Angle, the angle between the as described emergent light and the grating normal.
2. portable optical coherence chromatographic imaging instrument according to claim 1, it is characterised in that：The light source is LED wide
Band light source.
3. portable optical coherence chromatographic imaging instrument according to claim 1, it is characterised in that：The smart machine is
Mobile phone or tablet computer.
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| CN201510509005.1A CN105147250B (en) | 2015-08-19 | 2015-08-19 | A kind of portable optical coherence chromatographic imaging instrument |
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| CN201510509005.1A CN105147250B (en) | 2015-08-19 | 2015-08-19 | A kind of portable optical coherence chromatographic imaging instrument |
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| CN105147250B true CN105147250B (en) | 2018-10-19 |
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| CN105675615B (en) * | 2016-02-26 | 2018-04-06 | 苏州塞罗尔医学影像科技有限公司 | A kind of high speed large range high resolution rate imaging system |
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| WO2013027173A2 (en) * | 2011-08-21 | 2013-02-28 | Levitz David | Attaching optical coherence tomography systems onto smartphones |
| CN102710845B (en) * | 2012-01-18 | 2014-04-30 | 广州宝胆医疗器械科技有限公司 | Mobile phone with microscope and OCT (optical coherence tomography) functions |
| WO2013157673A1 (en) * | 2012-04-18 | 2013-10-24 | Lg Electronics Inc. | Optical coherence tomography and control method for the same |
| DE102012022058A1 (en) * | 2012-11-08 | 2014-05-08 | Carl Zeiss Meditec Ag | Flexible, multimodal retina image acquisition and measurement system |
| CN104224109B (en) * | 2014-10-16 | 2016-06-08 | 深圳市斯尔顿科技有限公司 | A kind of fundus camera in conjunction with OCT system |
| CN204839466U (en) * | 2015-08-19 | 2015-12-09 | 苏州赛罗尔医学影像科技有限公司 | Portable optics tomographic image appearance that is concerned with |
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Effective date of registration: 20191211 Address after: 210046 Nanjing bostek Photoelectric Technology Co., Ltd., No.18 Xianlin Avenue, Maqun street, Qixia District, Nanjing City, Jiangsu Province Patentee after: Nanjing bostaike Photoelectric Technology Co., Ltd Address before: 215600 building A, building 310, Zhangjiagang emerging industry incubation center, Suzhou, Jiangsu, China Patentee before: Suzhou Cerol Medical Imaging Technology Co., Ltd. |
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